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https://www.readbyqxmd.com/read/29470934/bivalent-oral-cholera-vaccine-in-participants-aged-1-year-and-older-in-the-dominican-republic-a-phase-iii-single-arm-safety-and-immunogenicity-trial
#1
Lina Cordero De Los Santos, Jesús Feris-Iglesias, Naveena Aloysia D'Cor, Venkata Jayanth Midde, Badri Narayan Patnaik, Yaël Thollot, Anvar Rasuli, Eric Desauziers
The Dominican Republic, historically non-endemic for cholera, is experiencing an ongoing cholera epidemic. We assessed the safety and immunogenicity of two doses of the killed bivalent (O1 and O139) whole-cell oral cholera vaccine (OCV) on day (D)0 and D14 in healthy participants aged ≥1 year. Immediate unsolicited systemic adverse events (AEs) were monitored up to 30 minutes and solicited systemic reactions, up to 7 days after each vaccination. Unsolicited AEs were recorded up to D14 (post-dose 1) and 30 days post-dose 2...
February 22, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29470317/the-effects-of-leukocyte-filtration-on-cell-salvaged-autologous-blood-transfusion-on-lung-function-and-lung-inflammatory-and-oxidative-stress-reactions-in-elderly-patients-undergoing-lumbar-spinal-surgery
#2
Lili Xu, Jianjun Shen, Jianliang Sun, Patrick M McQuillan, Zhiyong Hu
BACKGROUND: This study was designed to investigate the effects of leukocyte filtration of autologous salvaged blood on lung function, lung inflammatory reaction, and oxidative stress reaction in elderly patients undergoing lumbar spinal surgery. MATERIALS AND METHODS: Sixty elderly patients undergoing lumbar spinal surgery were randomly divided into 2 groups: Leukocyte Filter group and Control group. Serum levels of inflammatory markers including white blood cell and polymorphonuclear count, neutrophil elastase, serum surfactant protein A, methane dicarboxylic aldehyde, superoxide dismutase, interleukin (IL)-6, IL-8, tumor necrosis factor-α, and respiratory function markers including dynamic respiratory system compliance, oxygenation index, and respiratory index were measured immediately before induction of anesthesia (T0), immediately before blood transfusion (T1), and 1 (T2), 6 (T3), and 12 hours (T4) after end of blood transfusion...
February 21, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29469949/safety-profile-of-avelumab-in-patients-with-advanced-solid-tumors-a-pooled-analysis-of-data-from-the-phase-1-javelin-solid-tumor-and-phase-2-javelin-merkel-200-clinical-trials
#3
Karen Kelly, Jeffrey R Infante, Matthew H Taylor, Manish R Patel, Deborah J Wong, Nicholas Iannotti, Janice M Mehnert, Anja H Loos, Helga Koch, Isabell Speit, James L Gulley
BACKGROUND: Antibodies targeting the programmed death-ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) checkpoint may cause adverse events (AEs) that are linked to the mechanism of action of this therapeutic class and unique from those observed with conventional chemotherapy. METHODS: Patients with advanced solid tumors who were enrolled in the phase 1 JAVELIN Solid Tumor (1650 patients) and phase 2 JAVELIN Merkel 200 (88 patients) trials received avelumab, a human anti-PD-L1 IgG1 antibody at a dose of 10 mg/kg every 2 weeks...
February 22, 2018: Cancer
https://www.readbyqxmd.com/read/29469474/-clinical-analysis-of-12-cases-of-paragonimiasis
#4
Shi Ying-Hong, Long Bo
OBJECTIVE: To analyze the clinical characteristics of paragonimiasis and improve the level of diagnosis and treatment. METHODS: A retrospective analysis was made of 12 cases of paragonimiasis. RESULTS: All the paragonimiasis patients had the epidemiological history, 83.33% of them had the obvious blood eosinophil increase, and 83.33% of them had the positive antibody against Paragonimus. Praziquantel oral treatment had a curative effect and little adverse reaction...
August 15, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29469347/-mri-findings-of-cerebral-schistosomiasis-in-acute-stage%C3%AF-establishment-of-experimental-model-of-acute-cerebral-schistosomiasis-with-rabbits
#5
Ge Yu-Xi, Zhang Lian-He, Yan Gen, Zhang Jian-Feng, Pan Yong-Ming, Xuan Ying-Hua
OBJECTIVE: To establish an experimental model of acute cerebral schistosomiasis japonica and explore the MRI manifestations of acute cerebral schistosomiasis. METHODS: Rabbits were divided into 3 groups with 10 rabbits in each group. The rabbits in the experimental group were directly injected with suspension fluid of Schistosoma japonicum eggs (0.9 mg, 1 ml) by the cranial drilling method, those in the negative control group were given saline (1 ml) by the same method above-mentioned, and those in the blank control group were not given any treatment...
June 26, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29468640/prevalence-and-preventability-of-drug-related-hospital-readmissions-a-systematic-review
#6
REVIEW
Najla El Morabet, Elien B Uitvlugt, Bart J F van den Bemt, Patricia M L A van den Bemt, Marjo J A Janssen, Fatma Karapinar-Çarkit
OBJECTIVES: To summarize the evidence on the prevalence and preventability of drug-related hospital readmissions. DESIGN: A systematic review was performed of studies that examined drug-related hospital readmissions. PubMed, EMBASE, and the Cochrane Library were searched from inception through August 2016. Reference lists and a citation analysis on Web of Science and Scopus were also consulted. Two reviewers extracted study data with dual assessment of risk of bias...
February 22, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29467959/apatinib-as-a-third-or-further-line-treatment-in-patients-with-advanced-nsclc-harboring-wild-type-egfr
#7
Shencun Fang, Meiling Zhang, Guihong Wei, Kai-Hua Lu
Objectives: This study was conducted to evaluate the efficacy and safety of apatinib in advanced NSCLC patients with EGFR wild-type who have failed more than second-line chemotherapy. Materials and Methods: We retrospectively analyzed patients with EGFR wild-type advanced NSCLC who were treated with apatinib from January 2014 to August 2016. Objective response rate (ORR), disease control rate (DCR), progression free survival (PFS), overall survival (OS), and adverse events (AEs) were reveiwed and evaluated...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467876/comparison-of-the-safety-of-the-application-of-painless-gastroscopy-and-ordinary-gastroscopy-in-chronic-hypertension-patients-combined-with-early-gastric-cancer
#8
Fangli Men, Lianmin Wei, Bing Liu, Fengting Wu, Jingyu Liu, Ni Guo, Qing Niu
The aim of the present study was to compare the safety of the application of painless gastroscopy and ordinary gastroscopy for chronic hypertension patients combined with early gastric cancer. A total of 123 patients with early gastric cancer were selected at the Dongying People's Hospital from June, 2014 to August, 2016. The patients were randomly divided into the painless (n=63) and ordinary (n=60) gastroscopy groups. Proper pretreatment was performed according to whether anesthesia was performed or not. Arterial pressure, heart rate, and blood oxygen saturation were detected and compared before anesthesia, when gastroscope passed through the esophageal entrance plane, and after recovery from anesthesia...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467849/efficacy-and-survival-rate-of-intensity-modulated-radiotherapy-combined-with-chemotherapy-for-elderly-patients-with-locally-advanced-oropharyngeal-cancer
#9
Li Feng, Shummei Qi, Ming Lin
The efficacy of intensity-modulated radiotherapy (IMRT) combined with chemotherapy in the treatment of elderly patients with locally advanced oropharyngeal cancer and its effect on survival rate were studied. Elderly patients (n=150) diagnosed with locally advanced oropharyngeal cancer by histopathology were selected and randomly divided into the observation group (n=75) and the control group (n=75). Patients in the observation group were treated with IMRT combined with chemotherapy, while those in the control group were treated with conventional radiotherapy and chemotherapy...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29467656/sublingual-administration-of-sildenafil-oro-dispersible-film-new-profiles-of-drug-tolerability-and-pharmacokinetics-for-pde5-inhibitors
#10
Luca De Toni, Maurizio De Rocco Ponce, Erica Franceschinis, Stefano Dall'Acqua, Roberto Padrini, Nicola Realdon, Andrea Garolla, Carlo Foresta
Objective: Type 5 phosphodiesterase inhibitors (PDE5i) are efficient drugs used for treatment of erectile dysfunction (ED); however, a large discontinuation rate due to major side effects is reported. The aim of this study was to evaluate the possible improvement of sildenafil (Sild) pharmacokinetics associated to the sublingual administration of the new available oro-dispersible film (ODF), compared to both the oro-dispersible tablet (ODT) and the film-coated tablet (FCT) as original per os formulation. Methods: In vitro disaggregation test, dissolution test, and permeation test in specific devices to estimate the trans-mucosal absorption...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29467616/molecular-characterization-of-gaba-a-receptor-subunit-diversity-within-major-peripheral-organs-and-their-plasticity-in-response-to-early-life-psychosocial-stress
#11
Ethan A Everington, Adina G Gibbard, Jerome D Swinny, Mohsen Seifi
Gamma aminobutyric acid (GABA) subtype A receptors (GABAA Rs) are integral membrane ion channels composed of five individual proteins or subunits. Up to 19 different GABAA R subunits (α1-6, β1-3, γ1-3, δ, ε, θ, π, and ρ1-3) have been identified, resulting in anatomically, physiologically, and pharmacologically distinct multiple receptor subtypes, and therefore GABA-mediated inhibition, across the central nervous system (CNS). Additionally, GABAA R-modulating drugs are important tools in clinical medicine, although their use is limited by adverse effects...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29467307/effects-of-atx-ms-1467-immunotherapy-over-16-weeks-in-relapsing-multiple-sclerosis
#12
Jeremy Chataway, Keith Martin, Kevin Barrell, Basil Sharrack, Pelle Stolt, David C Wraith
OBJECTIVE: To assess safety, tolerability, and efficacy of the antigen-specific immunotherapy ATX-MS-1467 in participants with relapsing multiple sclerosis using different treatment protocols to induce tolerance. METHODS: Two open-label trials in adult participants with relapsing multiple sclerosis were conducted. Study 1 was a multicenter, phase 1b safety evaluation comparing intradermal (i.d.) (cohort 1) with subcutaneous (cohort 2) administration in 43 participants...
February 21, 2018: Neurology
https://www.readbyqxmd.com/read/29467147/alectinib-for-advanced-alk-positive-non-small-cell-lung-cancer
#13
REVIEW
Ashley C Ly, Jacqueline L Olin, Morgan B Smith
PURPOSE: The pharmacology, pharmacokinetics, clinical efficacy, safety and tolerability, dosage and administration, and place in therapy of alectinib for treatment of patients with non-small-cell lung cancer (NSCLC) are reviewed. SUMMARY: In patients with NSCLC driven by mutations of ALK , the gene coding for anaplastic lymphoma kinase (ALK), treatment with the ALK inhibitor crizotinib has been found to provide median progression-free survival (PFS) of 10.9 months; however, therapeutic failures and tumor progression to brain metastases are common with crizotinib use, prompting research to find more potent and tolerable ALK inhibitors that target major oncogenic drivers of NSCLC...
February 21, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29466923/impact-of-a-standardized-beta-lactam-allergy-questionnaire-on-aztreonam-use
#14
Kacie E Clark, Mary E Briand, Om Kapoor, Ameen Pirasteh
METHODS: This quasi-experimental study compared the aztreonam utilization in patients with self-reported beta-lactam allergies admitted to an inpatient service between two study periods (pre- and post-implementation). Post-implementation followed the initiation of a standardized beta-lactam allergy questionnaire, a student pharmacist-driven performance improvement project for beta-lactam allergy documentation. Interviews clarified the allergy, reaction history, and any previous tolerance of beta-lactams...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29466850/direct-costs-of-severe-cutaneous-adverse-reactions-in-a-tertiary-hospital-in-korea
#15
Min-Suk Yang, Ju-Young Kim, Min-Gyu Kang, Suh-Young Lee, Jae-Woo Jung, Sang-Heon Cho, Kyung-Up Min, Hye-Ryun Kang
Background/Aims: There are only a few reports on the direct costs of severe cutaneous adverse reactions (SCARs), including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN), despite the tremendous negative impact these reactions can have on patients. We estimated the direct costs of treating SCARs. Methods: Patients admitted to a tertiary teaching hospital for the treatment of SCARs from January 1, 2005 to December 31, 2010 were included...
February 23, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29466690/safety-and-efficacy-of-etanercept-methotrexate-combination-therapy-in-patients-with-rhupus-an-observational-study-of-non-glucocorticoid-treatment-for-rheumatic-diseases
#16
Bei-Bei Yang, Hua Xiao, Xiao-Jie Li, Min Zheng
OBJECTIVES: To evaluate the safety and efficacy of etanercept (ETN) plus methotrexate (MTX) in patients with rhupus without using corticosteroids. METHODS: Twenty rhupus patients [meeting the criteria for both rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)] who had never been treated with corticosteroids, DMARDs, or biological agents with a 28-joint Disease Activity Score (DAS28) >3.2 and lupus nephritis determined from histopathological specimens were enrolled...
January 2018: Discovery Medicine
https://www.readbyqxmd.com/read/29466493/preventable-adverse-drug-events-in-critically-ill-hiv-patients-is-the-detection-of-potential-drug-drug-interactions-a-useful-tool
#17
Grazielle Viana Ramos, André Miguel Japiassú, Fernando Augusto Bozza, Lusiele Guaraldo
OBJECTIVES: The aim of this study was to develop a strategy to identify adverse drug events associated with drug-drug interactions by analyzing the prescriptions of critically ill patients. METHODS: This retrospective study included HIV/AIDS patients who were admitted to an intensive care unit between November 2006 and September 2008. Data were collected in two stages. In the first stage, three prescriptions administered throughout the entire duration of these patients' hospitalization were reviewed, with the Micromedex database used to search for potential drug-drug interactions...
February 19, 2018: Clinics
https://www.readbyqxmd.com/read/29465758/an-adverse-effect-of-higher-catalyst-loading-and-longer-reaction-time-on-enantioselectivity-in-organocatalytic-multicomponent-reaction
#18
Ramakrishna G Bhat, Tushar M Khopade, Trimbak B Mete, Jyotsna S Arora
Enantioselective organocatalytic multicomponent reaction of aldehyde, ketone and Meldrum's acid has been developed for the first time. Cinchona based primary amine (1 mol%) catalyzes the multicomponent reaction via the formation of Knoevenagel product and chiral enamine to form enantiopure δ-keto Meldrum's acids in a tandem catalytic pathway. An adverse effect of higher catalytic loading and longer reaction time on enantioselectivity is studied. This mild protocol provides an easy access to enantiopure carboxylic acids, esters and amides and the method proved to be scalable on a gram scale...
February 21, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29465566/acupuncture-for-adults-with-overactive-bladder-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#19
Yuwei Zhao, Jing Zhou, Qian Mo, Yang Wang, Jinna Yu, Zhishun Liu
BACKGROUND: Overactive bladder is stated as the occurrence of urinary urgency which will cause negative impacts and decrease patients' health-related quality of life. The aim of this systematic review is to assess the efficiency and safety of acupuncture for adults with overactive bladder (OAB) comparing with sham-acupuncture, drugs, and acupuncture plus drugs. METHODS: We independently searched 9 databases from beginning to August 15, 2017. Two writers extracted data at the same time independently...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465560/olanzapine-and-haloperidol-for-the-treatment-of-acute-symptoms-of-mental-disorders-induced-by-amphetamine-type-stimulants-a-randomized-controlled-trial
#20
Xiaobin Xue, Yun Song, Xiaojie Yu, Qiang Fan, Jiyou Tang, Xu Chen
BACKGROUND: This study aimed to compare olanzapine and haloperidol efficacies in the treatment of acute psychiatric symptoms due to amphetamine-type stimulants (ATSs). METHODS: The Zelen II design method was used; 124 patients with acute mental disorders due to amphetamine were randomly divided into olanzapine group (n = 63) and haloperidol group (n = 61). Then, a 4-week open-label medical therapy was performed. Clinical Global Impression Scale Item 2 was employed to evaluate the onset time; meanwhile, Brief Psychiatric Rating Scale (BPRS) was used at baseline and at posttreatment weeks 1, 2, and 4...
February 2018: Medicine (Baltimore)
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