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https://www.readbyqxmd.com/read/29146633/comparison-of-outcomes-of-antibiotic-drugs-and-appendectomy-coda-trial-a-protocol-for-the-pragmatic-randomised-study-of-appendicitis-treatment
#1
Giana H Davidson, David R Flum, David A Talan, Larry G Kessler, Danielle C Lavallee, Bonnie J Bizzell, Farhood Farjah, Skye D Stewart, Anusha Krishnadasan, Erin E Carney, Erika M Wolff, Bryan A Comstock, Sarah E Monsell, Patrick J Heagerty, Annie P Ehlers, Daniel A DeUgarte, Amy H Kaji, Heather L Evans, Julianna T Yu, Katherine A Mandell, Ian C Doten, Kevin S Clive, Karen M McGrane, Brandon C Tudor, Careen S Foster, Darin J Saltzman, Richard C Thirlby, Erin O Lange, Amber K Sabbatini, Gregory J Moran
INTRODUCTION: Several European studies suggest that some patients with appendicitis can be treated safely with antibiotics. A portion of patients eventually undergo appendectomy within a year, with 10%-15% failing to respond in the initial period and a similar additional proportion with suspected recurrent episodes requiring appendectomy. Nearly all patients with appendicitis in the USA are still treated with surgery. A rigorous comparative effectiveness trial in the USA that is sufficiently large and pragmatic to incorporate usual variations in care and measures the patient experience is needed to determine whether antibiotics are as good as appendectomy...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29140639/determining-the-effectiveness-of-mirrors-and-camera-systems-in-monitoring-the-rearward-visibility-of-self-propelled-agricultural-machinery
#2
Shawn G Ehlers, William E Field
This study concerned the ability of operators of tractors and other self-propelled agricultural machinery to visually recognize objects and/or hazards within close proximity to the rear of those machines and/or any implements in tow, especially when backing up. It was hypothesized that the data collected would identify the factors affecting rearward visibility and help determine the effectiveness of two backup-assisting devices (i.e., mirrors and camera systems) in enhancing the operator's ability to observe objects or hazards...
July 31, 2017: Journal of Agricultural Safety and Health
https://www.readbyqxmd.com/read/29140617/methods-of-collecting-and-analyzing-rearward-visibility-data-for-agricultural-machinery-hazard-and-or-object-detectability
#3
Shawn G Ehlers, William E Field, Daniel R Ess
Recent interest in rearward visibility for private, construction, and commercial vehicles and documentation of rearward runovers involving bystanders outside the field of vision of the vehicle operator led to an investigation into the need for enhanced methods of rearward visibility for large, off-highway, agricultural equipment. A review of the literature found limited relevant research and minimal data on incidents involving rearward runovers of bystanders and co-workers. This article reviews the findings regarding the methods identified and tested to collect and analyze rearward visibility data, from the operator's perspective, for large self-propelled agricultural equipment, including the four-wheel drive tractors, combines, agricultural sprayers, and skid-steer loaders that are increasingly found on agricultural production sites...
January 26, 2017: Journal of Agricultural Safety and Health
https://www.readbyqxmd.com/read/29135936/a-role-of-sp1-binding-motifs-in-basal-and-large-t-antigen-induced-promoter-activities-of-human-polyomavirus-hpyv9-and-its-variant-uf-1
#4
Ugo Moens, Xiaobo Song, Marijke Van Ghelue, John A Lednicky, Bernhard Ehlers
Human polyomavirus 9 (HPyV9) was originally detected in the serum of a renal transplant patient. Seroepidemiological studies showed that ~20-50% of the human population have antibodies against this virus. HPyV9 has not yet been associated with any disease and little is known about the route of infection, transmission, host cell tropism, and genomic variability in circulating strains. Recently, the HPyV9 variant UF-1 with an eight base-pair deletion, a thirteen base-pair insertion and with point mutations, creating three putative Sp1 binding sites in the late promoter was isolated from an AIDS patient...
November 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29130629/in-reply-to-mast-cell-disorders-in-ehlers-danlos-syndrome
#5
Jaime Vengoechea
No abstract text is available yet for this article.
November 12, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29125009/exercise-beliefs-and-behaviours-of-individuals-with-joint-hypermobility-syndrome-ehlers-danlos-syndrome-hypermobility-type
#6
Jane V Simmonds, Anthony Herbland, Alan Hakim, Nelly Ninis, William Lever, Qasim Aziz, Mindy Cairns
PURPOSE: To explore exercise beliefs and behaviours of individuals with Joint Hypermobility syndrome/Ehlers-Danlos syndrome - hypermobility type and to explore patient experiences of physiotherapy. METHODS: A cross sectional questionnaire survey design was used to collect quantitative and qualitative data from adult members of the Hypermobility Syndromes Association and Ehlers-Danlos Syndrome Support UK. Descriptive and inferential statistics were used to analyse the data...
November 10, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29124259/correction-a-metal-free-fluorescence-turn-on-molecular-probe-for-detection-of-nucleoside-triphosphates
#7
Debabrata Maity, Mao Li, Martin Ehlers, Alba Gigante, Carsten Schmuck
Correction for 'A metal-free fluorescence turn-on molecular probe for detection of nucleoside triphosphates' by Debabrata Maity et al., Chem. Commun., 2017, 53, 208-211.
November 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29121166/characteristics-diagnosis-and-management-of-ehlers-danlos-syndromes-a-review
#8
Andrew W Joseph, Shannon S Joseph, Clair A Francomano, Theda C Kontis
Importance: Ehlers-Danlos syndromes (EDSs) are a group of heritable connective tissue disorders. Patients with EDSs can develop excessive facial rhytids, nasal deformities, and facial scarring, for which they may seek consultation with a facial plastic surgeon. Ehlers-Danlos syndromes can be associated with serious surgical complications and should be identified preoperatively to facilitate optimal treatment. To our knowledge, no management guidelines for patients with EDSs exist in the facial plastic surgery literature...
November 9, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29113876/-indirect-causes-of-maternal-deaths-except-stroke-cardiovascular-diseases-and-infections-results-from-the-french-confidential-enquiry-into-maternal-deaths-2010-2012
#9
V Le Guern, M Rossignol, A Proust
Maternal deaths of indirect causes result of a preexisting disease or an affection appeared during the pregnancy without any relationship with obstetrical causes, but worsened by the physiological effects of pregnancy. Among the 23 deaths of indirect cause related to a preexisiting pathology, 22 (96 %) have been analyzed by the expert comity. A known or preexisting chronic disease was documented in 16 patients (sick-cell disorder, n=3, treated epilepsy, n=3, intracerebral carvenomas, n=1, multifocal glial tumor, n=1, breast cancer, n=1, systemic lupus, n=1, diabetes mellitus, n=3, antiphospholipid syndrome, n=1)...
November 4, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29108857/applying-inbreeding-hybridization-and-mutagenesis-to-improve-oxidative-stress-tolerance-and-longevity-of-the-entomopathogenic-nematode-heterorhabditis-bacteriophora
#10
Nanette Hope Sumaya, Riddhi Gohil, Christopher Okolo, Temesgen Addis, Verena Doerfler, Ralf-Udo Ehlers, Carlos Molina
Poor shelf-life and sensitivity to environmental stress of entomopathogenic nematodes (EPNs) are traits, which deserve attention for improvement. Recently, a strong positive correlation between oxidative stress tolerance and longevity of Heterorhabditis bacteriophora dauer juveniles (DJs) has been reported. In this study, the improvement of H. bacteriophora DJ longevity was achieved by hybridization and mutagenesis. A hybrid pool deriving from two oxidative stress tolerant and long-living parental strains was generated...
November 3, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29106635/the-multisystemic-nature-and-natural-history-of-joint-hypermobility-syndrome-and-ehlers-danlos-syndrome-in-children-new-research-data-conflict-with-widely-held-views
#11
https://www.readbyqxmd.com/read/29099499/carotid-cavernous-fistula-current-concepts-in-aetiology-investigation-and-management
#12
A D Henderson, N R Miller
A carotid-cavernous fistula (CCF) is an abnormal communication between arteries and veins within the cavernous sinus and may be classified as either direct or dural. Direct CCFs are characterized by a direct connection between the internal carotid artery (ICA) and the cavernous sinus, whereas dural CCFs result from an indirect connection involving cavernous arterial branches and the cavernous sinus. Direct CCFs frequently are traumatic in origin and also may be caused by rupture of an ICA aneurysm within the cavernous sinus, Ehlers-Danlos syndrome type IV, or iatrogenic intervention...
November 3, 2017: Eye
https://www.readbyqxmd.com/read/29095685/novel-polyomaviruses-in-shrews-soricidae-with-close-similarity-to-human-polyomavirus-12
#13
Alma Gedvilaite, Morten Tryland, Rainer G Ulrich, Julia Schneider, Vaida Kurmauskaite, Ugo Moens, Hannah Preugschas, Sébastien Calvignac-Spencer, Bernhard Ehlers
Shrews (family Soricidae) have already been reported to host microorganisms pathogenic for humans. In an effort to search for additional infectious agents with zoonotic potential, we detected polyomaviruses (PyVs) in common shrew, crowned shrew, and pygmy shrew (Sorex araneus, S. coronatus and S. minutus). From these, 11 full circular genomes were determined. Phylogenetic analysis based on large T protein sequences showed that these novel PyVs form a separate clade within the genus Alphapolyomavirus. Within this clade, the phylogenetic relationships suggest host-virus co-divergence...
November 2, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29087633/use-of-patient-reported-outcomes-and-satisfaction-for-quality-assessments
#14
Anne P Ehlers, Sara Khor, Amy M Cizik, Jean-Christophe A Leveque, Neal S Shonnard, Rod J Oskouian, David R Flum, Danielle C Lavallee
OBJECTIVES: Recent focus on patient-reported outcomes (PROs) has created a new challenge as we learn how to integrate these outcomes into practice along with other quality metrics. We investigated the relationship between PROs and satisfaction among spine surgery patients. We hypothesized that there would be significant disparities between patient satisfaction and PROs at the 1-year postoperative time point. STUDY DESIGN: Retrospective cohort study of adults undergoing elective lumbar spine surgery at 12 hospitals participating in the Spine Surgical Care and Outcomes Assessment Program...
October 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29084269/non-muscle-myosin-iib-myh10-is-required-for-epicardial-function-and-coronary-vessel-formation-during-mammalian-development
#15
Liam A Ridge, Karen Mitchell, Ali Al-Anbaki, Wasay Mohiuddin Shaikh Qureshi, Louise A Stephen, Gennadiy Tenin, Yinhui Lu, Irina-Elena Lupu, Christopher Clowes, Abigail Robertson, Emma Barnes, Jayne A Wright, Bernard Keavney, Elisabeth Ehler, Simon C Lovell, Karl E Kadler, Kathryn E Hentges
The coronary vasculature is an essential vessel network providing the blood supply to the heart. Disruptions in coronary blood flow contribute to cardiac disease, a major cause of premature death worldwide. The generation of treatments for cardiovascular disease will be aided by a deeper understanding of the developmental processes that underpin coronary vessel formation. From an ENU mutagenesis screen, we have isolated a mouse mutant displaying embryonic hydrocephalus and cardiac defects (EHC). Positional cloning and candidate gene analysis revealed that the EHC phenotype results from a point mutation in a splice donor site of the Myh10 gene, which encodes NMHC IIB...
October 30, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29077546/genital-tract-screening-finds-widespread-infection-with-mustelid-gammaherpesvirus-1-in-the-european-badger-meles-meles
#16
Alice Kent, Bernhard Ehlers, Tom Mendum, Chris Newman, David W Macdonald, Mark Chambers, Christina D Buesching
Sexually transmitted diseases (STDs) can be important drivers of population dynamics because of their negative effects on reproduction. However, screening for STDs, especially in wildlife populations, is widely neglected. Using the promiscuous, polygynandrous European badger (Meles meles) as a model, we investigated the presence and prevalence of herpesviruses (HVs) in a wild, high-density population and assessed potential differences in somatic fitness and female reproductive condition between infected and uninfected individuals...
October 27, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29058589/translational-evidence-for-two-distinct-patterns-of-neuroaxonal-injury-in-sepsis-a-longitudinal-prospective-translational-study
#17
Johannes Ehler, Lucinda K Barrett, Valerie Taylor, Michael Groves, Francesco Scaravilli, Matthias Wittstock, Stephan Kolbaske, Annette Grossmann, Jörg Henschel, Martin Gloger, Tarek Sharshar, Fabrice Chretien, Francoise Gray, Gabriele Nöldge-Schomburg, Mervyn Singer, Martin Sauer, Axel Petzold
BACKGROUND: Brain homeostasis deteriorates in sepsis, giving rise to a mostly reversible sepsis-associated encephalopathy (SAE). Some survivors experience chronic cognitive dysfunction thought to be caused by permanent brain injury. In this study, we investigated neuroaxonal pathology in sepsis. METHODS: We conducted a longitudinal, prospective translational study involving (1) experimental sepsis in an animal model; (2) postmortem studies of brain from patients with sepsis; and (3) a prospective, longitudinal human sepsis cohort study at university laboratory and intensive care units (ICUs)...
October 23, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29050841/hemothorax-in-vascular-ehlers-danlos-syndrome
#18
Kevin Álvarez, López Jordi, Hernández Jose Angel
Vascular Ehlers-Danlos syndrome (EDS IV) is a rare genetic disorder characterized by an alteration in the COL3A1 gene which encodes type III collagen. It is the most common type of collagen in vessels of medium size and certain organs such as the intestines and the uterus. The alteration of this type of collagen produces aneurisms and ruptures of vessels and organs. A high level of clinical suspicion is required for diagnosis. It is a complex disease whose management requires a multidisciplinary team to treat the different complications that may occur...
October 16, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29049030/evidence-for-the-confinement-of-magnetic-monopoles-in-quantum-spin-ice
#19
P M Sarte, A A Aczel, G Ehlers, C Stock, B D Gaulin, C Mauws, M B Stone, S Calder, S E Nagler, J W Hollett, H D Zhou, J S Gardner, J P Attfield, C R Wiebe
Magnetic monopoles are hypothesised elementary particles connected by Dirac strings that behave like infinitely thin solenoids (Dirac 1931 Proc. R. Soc. A 133 60). Despite decades of searching, free magnetic monopoles and their Dirac strings have eluded experimental detection, although there is substantial evidence for deconfined magnetic monopole quasiparticles in spin ice materials (Castelnovo et al 2008 Nature 326 411). Here we report the detection of a hierarchy of unequally-spaced magnetic excitations via high resolution inelastic neutron spectroscopic measurements on the quantum spin ice candidate [Formula: see text] [Formula: see text] [Formula: see text]...
October 19, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29048248/rationale-and-development-of-a-patient-tailored-complex-intervention-of-case-management-for-patients-suffering-from-chronic-obstructive-pulmonary-disease
#20
Sabrina Storgaard Sørensen, Ulla Møller Weinreich, Lars Ehlers
This paper describes the rationale, considerations and choices made in developing a complex intervention evaluating the effectiveness and cost-effectiveness of community-based case management for chronic obstructive pulmonary disease patients in a Danish setting. Inspired by existing research methods for designing complex interventions, the intervention was developed using mixed methods entailing systematic review of available literature, interviews with key stakeholders and discussions in a specialist-comprised project group...
October 19, 2017: Home Health Care Services Quarterly
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