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Shannon R McCurdy, Mei-Jie Zhang, Andrew St Martin, Monzr M Al Malki, Asad Bashey, Sameh Gaballa, Daniel A Keesler, Mehdi Hamadani, Maxim Norkin, Miguel-Angel Perales, Ran Reshef, Vanderson Rocha, Rizwan Romee, Melhem Solh, Alvaro Urbano-Ispizua, Edmund K Waller, Ephraim J Fuchs, Mary Eapen
We studied the association between non-HLA donor characteristics (age, sex, donor-recipient relationship, blood group [ABO] match, and cytomegalovirus [CMV] serostatus) and transplant outcomes after T-cell-replete HLA-haploidentical transplantation using posttransplantation cyclophosphamide (PT-Cy) in 928 adults with hematologic malignancy transplanted between 2008 and 2015. Siblings (n = 358) and offspring (n = 450) were the predominant donors, with only 120 patients having received grafts from parents. Although mortality risks were higher with donors aged 30 years or older (hazard ratio, 1...
February 13, 2018: Blood Advances
Daniel Fiumecaldo, Lauren Buck
Chilaiditi's sign is a radiological finding that occurs when the small or large intestine is positioned superior to the liver in the sub-diaphragmatic space. This is typically an asymptomatic radiological sign, but when symptoms occur, e.g., abdominal pain, nausea, emesis, it is termed Chilaiditi's syndrome. Currently, majority of the cases of Chilaiditi's syndrome, described in the literature, requiring operative intervention are due to large bowel obstruction or colonic volvulus. The following is a single case report of a patient presenting to Keesler Medical Center in Biloxi, Mississippi...
February 5, 2018: Military Medicine
Kacie N Woodward, Rebekah I Keesler, J Rachel Reader, Kari L Christe
Because rhesus macaques (Macaca mulatta) are prolific breeders, overpopulation can be problematic in both research and feral populations. Currently, the most effective contraceptive methods are hormonal control in female macaques and vasectomies in males. These methods each come with innate challenges, the foremost being the alteration of necessary hormonal patterns. In this study, we assessed the use of zinc gluconate neutralized with arginine as a novel, nonsurgical alternative to male contraception in 12 rhesus macaques...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
Michael E Keesler, David DeMatteo
While conceptualization of psychopathy has evolved, so too has the public's relationship with psychology changed. Concurrently, portrayal of psychopaths has made several shifts, both through nonfiction sources and in popular film and television. Psychopathic villains of the mid-20th century have made space for a growing cast of protagonist psychopaths. This study examined whether a relationship existed between exposure to fictional psychopaths and how lay individuals conceptualize psychopathy. Specifically, this study explored conceptualization differences based on exposure to antagonist versus protagonist fictional psychopaths...
June 23, 2017: Journal of Forensic Sciences
A L Johnson, G D Simonek, R I Keesler
Pulmonary acariasis is a sporadic, incidental finding in colony-raised rhesus macaques (Macaca mulatta). Prophylactic treatment in indoor-raised and indoor-housed macaques is not routine due to low prevalence, lack of clinical significance, and potential risk of toxicosis. This case is an unusually severe infestation of Pneumonyssus simicola in an indoor-housed rhesus macaque, which ultimately resulted in this animal's death.
June 2017: Journal of Medical Primatology
Angela Colagross-Schouten, Marie-Josee Lemoy, Rebekah I Keesler, Elaine Lissner, Catherine A VandeVoort
BACKGROUND: Options for male contraception are limited. The purpose of this study was to use a nonhuman primate model to evaluate Vasalgel™, a high molecular weight polymer being developed as a contraceptive device for men. METHODS: Sixteen adult male rhesus monkeys received intravas injections of Vasalgel, consisting of 25% styrene maleic acid in dimethyl sulfoxide. After a one-week recovery, males were returned to outdoor group housing, which included at least 3 and up to 9 intact, breeding females with a successful reproductive history...
2017: Basic and Clinical Andrology
Lark L Coffey, Patricia A Pesavento, Rebekah I Keesler, Anil Singapuri, Jennifer Watanabe, Rie Watanabe, JoAnn Yee, Eliza Bliss-Moreau, Christina Cruzen, Kari L Christe, J Rachel Reader, Wilhelm von Morgenland, Anne M Gibbons, A Mark Allen, Jeff Linnen, Kui Gao, Eric Delwart, Graham Simmons, Mars Stone, Marion Lanteri, Sonia Bakkour, Michael Busch, John Morrison, Koen K A Van Rompay
Animal models of Zika virus (ZIKV) are needed to better understand tropism and pathogenesis and to test candidate vaccines and therapies to curtail the pandemic. Humans and rhesus macaques possess similar fetal development and placental biology that is not shared between humans and rodents. We inoculated 2 non-pregnant rhesus macaques with a 2015 Brazilian ZIKV strain. Consistent with most human infections, the animals experienced no clinical disease but developed short-lived plasma viremias that cleared as neutralizing antibody developed...
2017: PloS One
Michael E Keesler, Kirstie McClung, Tawny Meredith-Duliba, Kelli Williams, Thomas Swirsky-Sacchetti
OBJECTIVE: Evaluating assessment validity is expected in neuropsychological evaluation, particularly in cases with identified secondary gain, where malingering or somatization may be present. Assessed with standalone measures and embedded indices, all within the testing portion of the examination, research on validity of self-report in the clinical interview is limited. Based on experience with litigation-involved examinees recovering from mild traumatic brain injury (mTBI), it was hypothesized that inconsistently reported date of injury (DOI) and/or loss of consciousness (LOC) might predict invalid performance on neurocognitive testing...
April 2017: Clinical Neuropsychologist
Jason W Kempenich, Ross E Willis, Robert J Blue, Mohammed J Al Fayyadh, Robert M Cromer, Paul J Schenarts, Kent R Van Sickle, Daniel L Dent
OBJECTIVE: To decipher if patient attitudes toward resident participation in their surgical care can be improved with patient education regarding resident roles, education, and responsibilities. DESIGN: An anonymous questionnaire was created and distributed in outpatient surgery clinics that had residents involved with patient care. In total, 3 groups of patients were surveyed, a control group and 2 intervention groups. Each intervention group was given an informational pamphlet explaining the role, education, and responsibilities of residents...
November 2016: Journal of Surgical Education
Jason W Kempenich, Ross E Willis, Robert Rakosi, John Wiersch, Paul Joseph Schenarts
OBJECTIVE: Identify barriers to resident autonomy in today's educational environment as perceived through 4 selected groups: senior surgical residents, teaching faculty, hospital administration, and the general public. DESIGN: Anonymous surveys were created and distributed to senior residents, faculty, and hospital administrators working within 3 residency programs. The opinions of a convenience sample of the general public were also assessed using a similar survey...
November 2015: Journal of Surgical Education
John M Keesler
BACKGROUND: Trauma-informed care (TIC) is a systems-level philosophy of service delivery which integrates choice, collaboration, empowerment, safety and trust to create an organizational culture sensitive to trauma. This study explores staff understandings and perceptions within an innovative trauma-informed day program for individuals with Intellectual/developmental disabilities. METHODS: Semi-structured interviews queried staff members (n = 20) regarding trauma and TIC, the integration of the five principles of TIC, associated challenges and recommendations for improvement...
September 2016: Journal of Applied Research in Intellectual Disabilities: JARID
John M Keesler
In the United States, the Social Security Administration (SSA) provides financial benefits through Supplemental Security Income (SSI) to many individuals with intellectual and developmental disabilities (IDD). Family members and service coordinators (SCs) provide a critical role in applying for SSI on behalf of individuals with IDD. The present study uses a street-level lens to understand the implementation of SSI policy from the perspective of family respondents and SCs based upon their experiences with the application process...
February 2015: Intellectual and Developmental Disabilities
S Hiemstra, L Harkema, L C M Wiersma, R I Keesler
The liver can be an indicator of the health of an individual or of a group, which can be especially important to identify agents that can cause disease in multiple species. To better characterize hepatic lesions in stranded harbor porpoises (Phocoena phocoena), we analyzed the livers from 39 porpoises that stranded along the Dutch coast between December 2008 and December 2012. The animals were selected because they had either gross or histologic liver lesions with minimal autolysis and no evidence of trematode (Campula oblonga) infection...
November 2015: Veterinary Pathology
Isabelle Schrauwen, Renee M Barber, Scott J Schatzberg, Ashley L Siniard, Jason J Corneveaux, Brian F Porter, Karen M Vernau, Rebekah I Keesler, Kaspar Matiasek, Thomas Flegel, Andrew D Miller, Teresa Southard, Christopher L Mariani, Gayle C Johnson, Matthew J Huentelman
Necrotizing meningoencephalitis (NME) affects toy and small breed dogs causing progressive, often fatal, inflammation and necrosis in the brain. Genetic risk loci for NME previously were identified in pug dogs, particularly associated with the dog leukocyte antigen (DLA) class II complex on chromosome 12, but have not been investigated in other susceptible breeds. We sought to evaluate Maltese and Chihuahua dogs, in addition to pug dogs, to identify novel or shared genetic risk factors for NME development. Genome-wide association testing of single nucleotide polymorphisms (SNPs) in Maltese dogs with NME identified 2 regions of genome-wide significance on chromosomes 4 (chr4:74522353T>A, p = 8...
2014: PloS One
W Keith Berg
Frances Keesler Graham, noted psychophysiologist and developmental researcher, died on April 16, 2013. Fran was born in Canastota, New York, on August 1, 1918. Fran's high-quality research, her success in obtaining 39 years of uninterrupted funding, and the very high regard in which she was held among her colleagues led to numerous awards and honors. Fran was demanding but equally willing to provide extensive assistance to students willing to work hard.
September 2014: American Psychologist
David A Patterson, Catherine Dulmus, Eugene Maguin, John Keesler, Byron Powell
Several studies have demonstrated the effect of an organization's culture and climate on the delivery of services to clients and the success of clinical outcomes. Workers' perceptions are integral components of organizational social context, and in order to create a positive organizational culture and climate, managers and frontline staff need to have a shared understanding of the social context. The existing literature does not adequately address that discrepancies in perceptions of culture and climate between frontline staff and managers impact the implementation of policies and services...
June 13, 2014: Human Service Organizations, Management, Leadership & Governance
Marissa C Keesler, Fernanda Catharino, Luciana Q Closs, Nelson Mucha, Roberto Lima
No abstract text is available yet for this article.
March 2014: Dental Press Journal of Orthodontics
Floryne O Buishand, Judith Visser, Marja Kik, Andrea Gröne, Rebekah I Keesler, Inge H Briaire-de Bruijn, Jolle Kirpensteijn
Tissue microarray (TMA) technology allows analysis of multiple tumour samples simultaneously on a single slide. The aim of the present study was to develop and assess a TMA containing 32 primary canine insulinomas and 13 insulinoma metastases. The results of histopathological and immunohistochemical analyses of triplicate core biopsies were compared with those of individual tissue sections using weighted κ statistics. Inter-observer agreement of TMA immunohistochemistry scores were assessed for chromogranin A (CgA), insulin, growth hormone (GH), growth hormone receptor (GHR) and Ki67 index, as well as the prognostic utility of clinicopathological, histopathological and immunohistochemical criteria...
July 2014: Veterinary Journal
S Vreman, P Wiemer, R I Keesler
A 10-year-old KWPN (Royal Warmblood Studbook of the Netherlands) gelding was euthanized after developing severe neurological symptoms preceded by severe epistaxis during laser treatment for progressive ethmoid haematoma (PEH) in the right nasal cavity. Postmortem examination of the head revealed a large amount of clotted blood between the right ventral and dorsal conchae in the nasal cavity and acute haemorrhage in the right subarachnoid space. Histologically, there was moderate, acute polioencephalomalacia in the neuropil adjacent to the haemorrhage...
October 1, 2013: Tijdschrift Voor Diergeneeskunde
L Begeman, J A St Leger, D J Blyde, T P Jauniaux, S Lair, G Lovewell, S Raverty, H Seibel, U Siebert, S L Staggs, P Martelli, R I Keesler
Intestinal volvulus was recognized as the cause of death in 18 cetaceans, including 8 species of toothed whales (suborder Odontoceti). Cases originated from 11 institutions from around the world and included both captive (n = 9) and free-ranging (n = 9) animals. When the clinical history was available (n = 9), animals consistently demonstrated acute dullness 1 to 5 days prior to death. In 3 of these animals (33%), there was a history of chronic gastrointestinal illness. The pathological findings were similar to those described in other animal species and humans, and consisted of intestinal volvulus and a well-demarcated segment of distended, congested, and edematous intestine with gas and bloody fluid contents...
July 2013: Veterinary Pathology
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