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Barretts, Helicobacter Pylori

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https://www.readbyqxmd.com/read/27904862/risk-factors-for-barrett-s-oesophagus
#1
REVIEW
Neel Sharma, Khek Yu Ho
BACKGROUND: Barrett's oesophagus (BO) is a premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Globally, the incidence of OAC is rising. Furthermore, the prognosis regarding the morbidity and mortality of OAC is bleak, with an estimated 5-year survival of 10-15%. Hence, detection of the premalignant phase is paramount. Endoscopy and biopsy sampling is the mainstay of diagnosis. Patients may present with symptoms of gastro-oesophageal reflux disease (GORD) or be completely asymptomatic...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27862104/the-influence-of-helicobacter-pylori-on-the-ethnic-distribution-of-barrett-s-metaplasia
#2
A Sonnenberg, K O Turner, S J Spechler, R M Genta
BACKGROUND: Environmental risk factors associated with ethnicity may contribute to the occurrence of Barrett's metaplasia. AIM: Our aim was to investigate the interaction between ethnicity and Helicobacter pylori infection in the occurrence of Barrett's metaplasia among patients undergoing oesophago-gastro-duodenoscopy. METHODS: The Miraca Life Sciences Database is an electronic repository of histopathological patient records. A case-control study evaluated the influence of age, gender, ethnicity and histological diagnosis of H...
November 9, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27785038/association-of-medications-for-lifestyle-related-diseases-with-reflux-esophagitis
#3
Daisuke Asaoka, Akihito Nagahara, Mariko Hojo, Kenshi Matsumoto, Hiroya Ueyama, Kohei Matsumoto, Kentaro Izumi, Tsutomu Takeda, Hiroyuki Komori, Yoichi Akazawa, Yuji Shimada, Taro Osada, Sumio Watanabe
BACKGROUND: Because of a change in lifestyle, especially adoption of westernized eating habits, lifestyle-related diseases have become increasingly prevalent. The aim of this study was to investigate the association of medications for lifestyle-related diseases with reflux esophagitis (RE). METHODS: We conducted a hospital-based, cross-sectional retrospective study of consecutive outpatients who received an upper gastrointestinal endoscopy in our department from February 2008 to November 2014, which was performed by one specialist who was a member of the Japan Gastroenterological Endoscopy Society...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27741173/gut-microbiome-and-gastrointestinal-cancer-les-liaisons-dangereuses
#4
Nurdan Tözün, Eser Vardareli
Gastrointestinal (GI) cancers are the leading cause of mortality worldwide. These cancers are the end result of a complex interplay between gene and environment. Bacteria, parasites, and viruses have been implicated in some cancers. Recent data have put at focus the gut microbiome as the key player firing tumorigenesis. Experimental and human studies have provided evidence on the role of microbiota in cancer development. Although subject to changes in different settings such as antibiotic treatment, diet or lifestyle, our microbiome is quite stable and is capable of increasing susceptibility to cancer or decrease and halt its progression...
November 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27681974/barrett-s-oesophagus-epidemiology-diagnosis-and-clinical-management
#5
David C Whiteman, Bradley J Kendall
Barrett's oesophagus is a condition characterised by partial replacement of the normal squamous epithelium of the lower oesophagus by a metaplastic columnar epithelium containing goblet cells (intestinal metaplasia). Barrett's oesophagus is important clinically because those afflicted are predisposed to oesophageal adenocarcinoma. Prevalence surveys suggest that up to 2% of the population may be affected; most will be unaware of their diagnosis. Risk factors include age, male sex, gastro-oesophageal acid reflux, central obesity and smoking...
October 3, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27623934/opportunities-for-preventing-esophageal-adenocarcinoma
#6
John Maret-Ouda, Hashem El-Serag, Jesper Lagergren
Esophageal adenocarcinoma is rapidly increasing in incidence in many Western societies, requires demanding treatment and is associated with a poor prognosis, therefore preventive measures are highly warranted. To assess the opportunities for prevention, we reviewed the available literature and identified seven main potentially preventive targets. Preventive effects were found based on medium level observational evidence following treatment of gastroesophageal reflux disease (both using medication and surgery) and tobacco smoking cessation, which should be clinically recommended among exposed patients...
September 13, 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27573783/helicobacter-pylori-and-gastric-cancer-timing-and-impact-of-preventive-measures
#7
Marino Venerito, Riccardo Vasapolli, Peter Malfertheiner
Helicobacter pylori (H. pylori) is a Gram negative spiraliform bacterium that is commonly found in the stomach. H. pylori infection is still one of the world's most frequent infections, present in the stomachs of approximately one-half of the world's people. H. pylori infection is etiologically linked to histologic chronic active gastritis, peptic ulcer disease, and primary B-cell gastric lymphoma (gastric MALT lymphoma) and represents the major risk factor for the development of sporadic non-cardia gastric cancer (GC) of both intestinal and diffuse type...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27571792/russell-body-inflammatory-polyp-a-case-report-and-review-of-literature
#8
Ryan F Coates, Nicholas Ferrentino, Michelle X Yang
Russell body gastroenteritis has been reported as a reactive inflammatory process in most cases and many of the reports were from the upper gastrointestinal tract, especially the stomach, which may be associated with Helicobacter pylori infection and rarely associated with gastric carcinoma. Russell body containing Mott cells have been rarely seen in Barrett's esophagus and duodenum, and only 2 cases have been reported in colon, including a transplant patient with diarrhea and a rectal tubulovillous adenoma...
August 29, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27567957/increased-oxidative-stress-in-the-proximal-stomach-of-patients-with-barrett-s-esophagus-and-adenocarcinoma-of-the-esophagus-and-esophagogastric-junction
#9
Juha Kauppi, Jari Räsänen, Eero Sihvo, Urpo Nieminen, Perttu Arkkila, Markku Ahotupa, Jarmo Salo
OBJECTIVES: Oxidative stress (OS) is an essential element in the pathogenesis of Barrett's esophagus (BE) and its transformation to adenocarcinoma (EAC). The state of OS in the proximal stomach of patients with BE and EAC is unknown. Isoprostanes are a specific marker of OS not previously used to determine OS from BE/EAC tissue samples. PATIENTS AND METHODS: OS was measured in 42 patients with BE (n = 9), EAC (n = 9), or both (n = 24) and 15 control patients. A STAT-8-Isoprostane EIA Kit served to identify 8-Isoprostanes (8-IP), and a Glutathione Assay Kit was used to measure glutathione reduced form (GSH) and glutathione oxidized form...
August 2016: Translational Oncology
https://www.readbyqxmd.com/read/27531536/helicobacter-pylori-and-non-malignant-upper-gastrointestinal-diseases
#10
Riccardo Vasapolli, Peter Malfertheiner, Arne Kandulski
Peptic ulcer disease (PUD) has been further decreased over the last decades along with decreasing prevalence of Helicobacter pylori-associated PUD. A delayed H. pylori eradication has been associated with an increased risk of rehospitalization for complicated recurrent peptic ulcer and reemphasized the importance of eradication especially in patients with peptic ulcer bleeding (PUB). PUB associated with NSAID/aspirin intake and H. pylori revealed an additive interaction in gastric pathophysiology which favors the "test-and-treat" strategy for H...
September 2016: Helicobacter
https://www.readbyqxmd.com/read/27520775/management-of-helicobacter-pylori-infections
#11
Amin Talebi Bezmin Abadi, Johannes G Kusters
BACKGROUND: Infection with Helicobacter pylori is associated with severe digestive diseases including chronic gastritis, peptic ulcer disease, and gastric cancer. Successful eradication of this common gastric pathogen in individual patients is known to prevent the occurrence of peptic ulcer disease and gastric cancer. DISCUSSION: With half of the world's population being infected with H, pylori and only few antibiotics result in an effective eradication, a successful antibiotic driven worldwide eradication program seems unlikely...
August 12, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27430081/gastric-polyp-growth-during-endoscopic-surveillance-for-esophageal-varices-or-barrett-s-esophagus
#12
Dan M Livovsky, Orit Pappo, Galina Skarzhinsky, Asaf Peretz, Elliot Turvall, Zvi Ackerman
BACKGROUND: We recently observed patients with chronic liver disease (CLD) or chronic reflux symptoms (CRS) who developed gastric polyps (GPs) while undergoing surveillance gastroscopies for the detection of esophageal varices or Barrett's esophagus, respectively. OBJECTIVES: To identify risk factors for GP growth and estimate its growth rate. METHODS: GP growth rate was defined as the number of days since the first gastroscopy (without polyps) in the surveillance program, until the gastroscopy when a GP was discovered...
May 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/27381266/risk-factors-for-erosive-and-non-erosive-gastroesophageal-reflux-disease-and-barrett-s-esophagus-in-nothern-sardinia
#13
Maria Pina Dore, Giovanni Mario Pes, Gabrio Bassotti, Maria Antonietta Farina, Giuseppina Marras, David Yates Graham
OBJECTIVE: Gastroesophageal reflux disease (GERD) and esophageal adenocarcinoma have been increasing. We studied the relationship of conventional risk factors and Helicobacter pylori infection in patients with erosive and non-erosive GERD and Barrett's esophagus. MATERIALS AND METHODS: This was a retrospective study of dyspeptic patients undergoing upper endoscopy between 2002 and 2013. Following endoscopy, those with previously undiagnosed GERD were sub-grouped into non-erosive GERD (NERD), erosive GERD (eGERD), or Barrett's esophagus...
November 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27102559/importance-of-the-alternative-nf-%C3%AE%C2%BAb-activation-pathway-in-inflammation-associated-gastrointestinal-carcinogenesis
#14
REVIEW
Yvette J Merga, Adrian O'Hara, Michael D Burkitt, Carrie A Duckworth, Christopher S Probert, Barry J Campbell, D Mark Pritchard
Chronic inflammation is a common factor in the development of many gastrointestinal malignancies. Examples include inflammatory bowel disease predisposing to colorectal cancer, Barrett's esophagus as a precursor of esophageal adenocarcinoma, and Helicobacter pylori-induced gastric cancer. The classical activation pathway of NF-κB signaling has been identified as regulating several sporadic and inflammation-associated gastrointestinal tract malignancies. Emerging evidence suggests that the alternative NF-κB signaling pathway also exerts a distinct influence on these processes...
June 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/26840528/prevalence-of-upper-gastrointestinal-endoscopic-findings-in-the-community-a-systematic-review-of-studies-in-unselected-samples-of-subjects
#15
Rocco Maurizio Zagari, Leonardo Henry Eusebi, Stefano Rabitti, Laura Cristoferi, Amanda Vestito, Nico Pagano, Franco Bazzoli
BACKGROUND AND AIM: Upper gastrointestinal endoscopic findings, such as esophagitis, Barrett's esophagus, peptic ulcer, and malignancy, represent a public health problem. This systematic review aimed to evaluate the prevalence of upper gastrointestinal endoscopic findings in the community. METHODS: A systematic search was conducted in PUBMED and EMBASE to May 2015. Studies were eligible if they reported the prevalence of upper gastrointestinal endoscopic findings in unselected samples of the community...
September 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26611860/premature-birth-and-large-for-gestational-age-are-associated-with-risk-of-barrett-s-esophagus-in-adults
#16
Seiji Shiota, Hashem B El-Serag, Aaron P Thrift
BACKGROUND: Birth characteristics, including weight and gestational age, may be associated with risk of Barrett's esophagus (BE), the only known precursor for esophageal adenocarcinoma; however, data are limited. AIMS: To examine associations between various birth characteristics and BE, and whether these associations are mediated by known risk factors for BE. METHODS: Data were obtained from a cross-sectional study among eligible Veterans Affairs patients scheduled for an upper endoscopy, and a sample identified from primary care clinics...
April 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26560097/safety-of-proton-pump-inhibitors-and-risk-of-gastric-cancers-review-of-literature-and-pathophysiological-mechanisms
#17
REVIEW
Yanna Ko, James Tang, Santosh Sanagapalli, Bong Sik Matthew Kim, Rupert W Leong
INTRODUCTION: Despite being an overall safe drug, several long-term adverse effects are associated with proton pump inhibitors (PPIs). The link between PPI use and gastric neuroendocrine tumors (NETs), gastric adenocarcinomas and Barrett's esophagus progression gastric cancers has been investigated due to PPI-induced hypergastrinemia. AREAS COVERED: The pathophysiological mechanisms underlying PPI exposure and gastric NETs, gastric adenocarcinomas and Barrett's esophagus progression are discussed...
January 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/26165069/-barrett-s-esophagus-its-diagnosis-and-management-in-japan
#18
Yuji Amano, Takane Azumi
The incidence of adenocarcinoma derived from Barrett's esophagus has been steadily increasing during the past some decades in Western countries. The development of better diagnostic and therapeutic strategies for Barrett's esophagus and Barrett's adenocarcinoma have become an important objective. In Japan, Barrett's adenocarcinoma has been gradually increasing as the results of a high incidence of reflux esophagitis, a decreasing of Helicobacter pylori infection and an increasing of obesity, etc. Subsequently, in recent, the management of Barrett's esophagus has come to be of interest as well as in the Western countries...
July 2015: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/26140632/esophagogastric-pathology-in-morbid-obese-patient-preoperative-diagnosis-influence-in-the-selection-of-surgical-technique
#19
Sergio Estévez-Fernández, Raquel Sánchez-Santos, Esther Mariño-Padín, Sonia González-Fernández, Juan Turnes-Vázquez
INTRODUCTION: Given the difficulty in accessing to the excluded stomach after gastric bypass and the increase in gastroesophageal reflux after sleeve gastrectomy, it is justified to perform a preoperative fibrogastroscopy.The influence of the fibrogastroscopy (FGS) findings in the therapeutic approach is analyzed. PATIENTS AND METHODS: A retrospective study of preoperative FGS findings is performed, from 04/06 to 12/12. The influence of the FGS results on the surgical technique selection, in the endoscopic or medical treatment and its relation to gastric fistula is analyzed by means of multivariate regression (confounding factors: Age, body mass index, arterial hypertension, diabetes mellitus, antiplatelet therapy, surgical technique (bariatric surgery, sleeve gastrectomy)...
July 2015: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/26129758/relationship-between-helicobacter-pylori-infection-and-multiple-sclerosis
#20
Emmanuel Gavalas, Jannis Kountouras, Marina Boziki, Christos Zavos, Stergios A Polyzos, Efthymia Vlachaki, Ioannis Venizelos, Dimitrios Tsiptsios, Georgia Deretzi
BACKGROUND: Recent data indicate the presence of immunomodulating properties of Helicobacter pylori (Hp) (Hp Sydney Strain-1 antigen) in an experimental model of multiple sclerosis (MS), and there are limited contradictory epidemiologic data regarding Hp serology in MS patients. METHODS: The aim of this prospective, comparative study was to validate the incidence of active Hp infection by histology and the endoscopic abnormalities, in 44 patients with relapsing-remitting MS and 20 anemic controls...
July 2015: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
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