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https://www.readbyqxmd.com/read/27492354/a-combined-nissen-plus-hill-hybrid-repair-for-paraesophageal-hernia-improves-clinical-outcomes-and-reduces-long-term-recurrences-compared-with-laparoscopic-nissen-alone
#1
Gal Levy, Ralph W Aye, Alexander S Farivar, Brian E Louie
INTRODUCTION: We compared clinical and objective outcomes of combined Nissen-Hill hybrid (HYB) to Nissen fundoplication (LNF) for repair of paraesophageal hernia (PEH). METHODS: This study is a single-institution retrospective chart review of prospectively collected data for consecutive patients undergoing PEH repair from 2006 to 2015 with at least 6 months of follow-up. Quality of life metrics (QOLRAD, HRQL, and dysphagia), manometry, radiographic imaging, and pH testing were administered pre- and postoperatively...
August 4, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27448962/gastrin-stimulates-a-cholecystokinin-2-receptor-expressing-cardia-progenitor-cell-and-promotes-progression-of-barrett-s-like-esophagus
#2
Yoomi Lee, Aleksandra M Urbanska, Yoku Hayakawa, Hongshan Wang, Andrew S Au, Aesis M Luna, Wenju Chang, Guangchun Jin, Govind Bhagat, Julian A Abrams, Richard A Friedman, Andrea Varro, Kenneth K Wang, Malcolm Boyce, Anil K Rustgi, Antonia R Sepulveda, Michael Quante, Timothy C Wang
OBJECTIVE: The incidence of esophageal adenocarcinoma (EAC) is increasing, but factors contributing to malignant progression of its precursor lesion, Barrett's esophagus (BE), have not been defined. Hypergastrinemia caused by long-term use of proton pump inhibitors (PPIs), has been suggested as one possible risk factor. The gastrin receptor, CCK2R, is expressed in the cardia and upregulated in BE, suggesting the involvement of the gastrin-CCK2R pathway in progression. In the L2-IL-1β mouse model, Barrett's-like esophagus arises from the gastric cardia...
July 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27373671/radiofrequency-ablation-of-symptomatic-cervical-inlet-patch-using-a-through-the-scope-device-a-pilot-study
#3
Jason Mark Dunn, Guiping Sui, Angela Anggiansah, Terence Wong
BACKGROUND AND AIMS: The cervical inlet patch (CIP) is an area of heterotopic gastric mucosa at the proximal esophagus, which can secrete both acid and mucus. Attributable symptoms include chronic globus sensation and sore throat. Previous studies have demonstrated improvement in symptoms after ablation using argon plasma coagulation. Our aim was to assess a through-the-scope radiofrequency ablation (RFA) catheter for ablation of symptomatic CIP. METHODS: Ten patients with endoscopically and histologically proven CIP and symptoms of globus or sore throat were included in the study...
December 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27325300/evidence-based-clinical-practice-guidelines-for-gastroesophageal-reflux-disease-2015
#4
REVIEW
Katsuhiko Iwakiri, Yoshikazu Kinoshita, Yasuki Habu, Tadayuki Oshima, Noriaki Manabe, Yasuhiro Fujiwara, Akihito Nagahara, Osamu Kawamura, Ryuichi Iwakiri, Soji Ozawa, Kiyoshi Ashida, Shuichi Ohara, Hideyuki Kashiwagi, Kyoichi Adachi, Kazuhide Higuchi, Hiroto Miwa, Kazuma Fujimoto, Motoyasu Kusano, Yoshio Hoshihara, Tatsuyuki Kawano, Ken Haruma, Michio Hongo, Kentaro Sugano, Mamoru Watanabe, Tooru Shimosegawa
As an increase in gastroesophageal reflux disease (GERD) has been reported in Japan, and public interest in GERD has been increasing, the Japanese Society of Gastroenterology published the Evidence-based Clinical Practice Guidelines for GERD (1st edition) in 2009. Six years have passed since its publication, and there have been a large number of reports in Japan concerning the epidemiology, pathophysiology, treatment, and Barrett's esophagus during this period. By incorporating the contents of these reports, the guidelines were completely revised, and a new edition was published in October 2015...
August 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/26945777/radiofrequency-ablation-coupled-with-roux-en-y-gastric-bypass-a-treatment-option-for-morbidly-obese-patients-with-barrett-s-esophagus
#5
Keyur Parikh, Leena Khaitan
Barrett's esophagus (BE) is a premalignant condition that is associated with the development of esophageal adenocarcinoma. Risk factors that have been associated with the development of BE include male gender, Caucasian race, chronic gastroesophageal reflux disease, smoking, age >50 and obesity. The current management of BE is dependent on underlying pathological changes and treatment can range from surveillance endoscopy with daily proton pump inhibitor (PPI) therapy in the setting of intestinal metaplasia or low-grade dysplasia (LGD) to radiofrequency ablation (RFA), endoscopic mucosal resection or surgical resection in the setting of high-grade dysplasia...
2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/26926861/peptic-esophageal-stricture-in-an-adolescent-with-barrett-s-esophagus
#6
Sandeep Lamoria, Arka De, Somya Agarwal, Brinder Mohan Singh Lamba, Vishal Sharma
Barrett's esophagus (BE) is characterized by the replacement of distal esophageal stratified squamous epithelium by columnar epithelium. It is rare in children and the risk factors may include mental retardation, cerebral palsy, esophageal atresia, etc. Apart from corrosive ingestion, peptic stricture is the other leading cause of esophageal strictures in children. However, BE has not been well characterized in the pediatric population and in children presenting with esophageal strictures. A 16-year-old Indian boy presented with a history of gradually progressive dysphagia to solids (but not liquids) for 12 years along with heartburn and poor weight gain...
February 27, 2016: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/26772891/rates-and-predictors-of-progression-to-esophageal-carcinoma-in-a-large-population-based-barrett-s-esophagus-cohort
#7
Rajesh Krishnamoorthi, Bijan Borah, Herbert Heien, Ananya Das, Amitabh Chak, Prasad G Iyer
BACKGROUND AND AIMS: Rates of progression to esophageal adenocarcinoma in subjects with Barrett's esophagus (BE) are lower than previously estimated. Identification of predictors of progression will enable risk stratification of BE subjects, potentially making current surveillance programs more efficient. We aimed to assess the potential of demographic and lifestyle factors, obesity, and medications in predicting progression in BE. METHODS: BE subjects were identified from the General Practice Research Database using validated diagnostic codes...
July 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/26659238/significance-of-nissen-fundoplication-after-endoscopic-radiofrequency-ablation-of-barrett-s-esophagus
#8
Ognjan Skrobić, Aleksandar Simić, Nebojša Radovanović, Nenad Ivanović, Marjan Micev, Predrag Peško
OBJECTIVE: HALO radiofrequency ablation (RFA) has been proven as safe and efficient in eradication of both non- and dysplastic Barrett's esophagus (BE). Definitive post-RFA treatment is yet to be determined. METHODS: RFA was performed in 56 patients with BE, 38 with intestinal metaplasia (IM) and 18 with low-grade dysplasia (LGD), and repeated in case of residual BE. Length of the BE was classified according to C&M criteria. Follow-up included regular upper GI endoscopies with biopsies 6 months, 1 and 2 years after the complete resolution of BE...
September 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26545949/-a-comparison-of-medical-versus-surgical-treatment-in-barrett-s-esophagus-acid-control
#9
Nereida Fernández Fernández, Ana B Domínguez Carbajo, Diana João Matias, Laura Rodríguez-Martín, Marta Aparicio Cabezudo, Luz Monteserín Ron, Marcos Jiménez Palacios, Santiago Vivas
INTRODUCTION: Barrett's oesophagus (BE) is an oesophageal injury caused by gastroesophageal acid reflux. One of the main aims of treatment in BE is to achieve adequate acid reflux control. OBJECTIVE: To assess acid reflux control in patients with BE based on the therapy employed: medical or surgical. METHODS: A retrospective study was performed in patients with an endoscopic and histological diagnosis of BE. Medical therapy with proton pump inhibitors (PPI) was compared with surgical treatment (Nissen fundoplication)...
May 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/26541740/multi-institutional-outcomes-using-magnetic-sphincter-augmentation-versus-nissen-fundoplication-for-chronic-gastroesophageal-reflux-disease
#10
Heather F Warren, Jessica L Reynolds, John C Lipham, Joerg Zehetner, Nikolai A Bildzukewicz, Paul A Taiganides, Jody Mickley, Ralph W Aye, Alexander S Farivar, Brian E Louie
BACKGROUND: Magnetic sphincter augmentation (MSA) has emerged as an alternative surgical treatment of gastroesophageal reflux disease (GERD). The safety and efficacy of MSA has been previously demonstrated, although adequate comparison to Nissen fundoplication (NF) is lacking, and required to validate the role of MSA in GERD management. METHODS: A multi-institutional retrospective cohort study of patients with GERD undergoing either MSA or NF. Comparisons were made at 1 year for the overall group and for a propensity-matched group...
August 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26520196/-oesophageal-diseases-gastroesophageal-reflux-disease-barrett-s-disease-achalasia-and-eosinophilic-oesophagitis
#11
Xavier Calvet
The most important novel findings presented on oesophageal disease in DDW 2015 were the following: 1) GERD: a) hypervigilance seems to be a key pathogenic factor in reflux symptoms refractory to PPI; b) post-reflux swallowing-induced peristaltic waves could be an excellent diagnostic criterion for GERD; c) laryngeal pH-metry is not useful in the diagnosis of extra-oesophageal symptoms; d) the recommendation of weight loss adequately recorded in the clinical reports of patients with GERD and obesity or overweight is an excellent quality indicator and is associated with better outcomes...
September 2015: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/26386080/sporadic-fundic-gland-polyps-with-low-grade-dysplasia-a-large-case-series-evaluating-pathologic-and-immunohistochemical-findings-and-clinical-behavior
#12
Mary D Levy, Baishali Bhattacharya
OBJECTIVES: Fundic gland polyps (FGPs) occur in two clinical settings, sporadic and syndromic. Epithelial dysplasia is rare in sporadic FGPs, and progression data from large series are lacking. The aim of this study was to evaluate the clinical, morphologic, and immunohistochemical features in a large series of sporadic FGPs with epithelial dysplasia. METHODS: We studied 85 patients with FGPs with low-grade dysplasia (FGPD), including 62 patients with sporadic and 23 with syndromic FGPDs...
October 2015: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/26340602/efficacy-of-viscous-budesonide-slurry-for-prevention-of-esophageal-stricture-formation-after-complete-endoscopic-mucosal-resection-of-short-segment-barrett-s-neoplasia
#13
Farzan F Bahin, Mahesh Jayanna, Stephen J Williams, Eric Y T Lee, Michael J Bourke
BACKGROUND AND AIMS: Complete endoscopic resection (CER) of short-segment Barrett's esophagus with high grade dysplasia (HGD) and early esophageal adenocarcinoma (EEA) is a precise staging tool and achieves durable disease control. The major drawback is development of post-endoscopic resection esophageal stricture (PERES). No effective therapy to prevent PERES has been described. Viscous budesonide slurry (VBS) may have a role in the prevention of PERES by suppressing the post-CER inflammatory process...
January 2016: Endoscopy
https://www.readbyqxmd.com/read/26214788/metformin-plus-proton-pump-inhibitors-therapy-the-cobalamin-deficiency-challenge
#14
F Purchiaroni, G Galli, B Annibale
OBJECTIVE: It is known in literature that metformin and proton pump inhibitors (PPIs) are associated to cobalamin levels reduction independently but still very little is known about the combination of the two drugs in cobalamin levels decrease. Currently there are no published data concerning the management of patients with cobalamin deficiency related to the concomitant use of the aforementioned drugs. CASE REPORT: We present the case of a 65 year-old white man with an history of renal cell carcinoma, melanoma and hepatic nodular sclerosis Hodgkin's lymphoma, who was under treatment with metformin because of diabetes and with pantoprazole because of Barrett's esophagus...
July 2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26187027/one-year-treatment-of-barrett-s-oesophagus-with-proton-pump-inhibitors-a-multi-center-study
#15
Z Babic, Z Bogdanovic, Z Dorosulic, Z Petrovic, M Kujundzic, M Banic, M Marusic, R Heinzl, B Bilić, M Andabak
OBJECTIVES: Aim of the study was to investigate the effects of 1-year therapy by different proton pump inhibitors (PPIs) on epithelial tissue and surrounding inflammatory changes in Barrett's oesophagus, in patients who have abandoned invasive therapy. METHODS: A group of 120 patients (sampled in 60-month period, from 61201 upper gastrointestinal endoscopies) who were diagnosed both, endoscopically and pathohistologically with Barrett's oesophagus, and who have abandoned invasive therapeutic approach were enrolled in study...
July 17, 2015: Acta Clinica Belgica
https://www.readbyqxmd.com/read/26130628/unmet-needs-in-the-treatment-of-gastroesophageal-reflux-disease
#16
Ram Dickman, Carla Maradey-Romero, Rachel Gingold-Belfer, Ronnie Fass
Gastroesophageal reflux disease (GERD) is a highly prevalent gastrointestinal disorder. Proton pump inhibitors have profoundly revolutionized the treatment of GERD. However, several areas of unmet need persist despite marked improvements in the ther-apeutic management of GERD. These include the advanced grades of erosive esophagitis, nonerosive reflux disease, main-tenance treatment of erosive esophagitis, refractory GERD, postprandial heartburn, atypical and extraesophageal manifestations of GERD, Barrett's esophagus, chronic protein pump inhibitor treatment, and post-bariatric surgery GERD...
July 30, 2015: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/26106373/reflux-esophagitis-triggered-after-helicobacter-pylori-eradication-a-noteworthy-demerit-of-eradication-therapy-among-the-japanese
#17
Katsunori Iijima, Tomoyuki Koike, Tooru Shimosegawa
In the February 2013 Revision of Insured Medical Treatment, bacterial eradication for all Helicobacter pylori-positive individuals in Japan was covered under the insurance scheme. However, reflux esophagitis is believed to occur in approximately 10% of Japanese patients who undergo eradication therapy. Hence, the risk of reflux esophagitis among such cases should be carefully considered, particularly in the treatment for H. pylori-positive patients who are otherwise healthy. The eradication of H. pylori in cases of H...
2015: Frontiers in Microbiology
https://www.readbyqxmd.com/read/26077392/local-synthesis-of-pepsin-in-barrett-s-esophagus-and-the-role-of-pepsin-in-esophageal-adenocarcinoma
#18
Tina Samuels, Craig Hoekzema, Jon Gould, Matthew Goldblatt, Matthew Frelich, Matthew Bosler, Sang-Hyuk Lee, Nikki Johnston
OBJECTIVE: Despite widespread use of proton pump inhibitors (PPIs), the incidence of esophageal adenocarcinoma (EAC) continues to rise. PPIs reduce reflux acidity, but only transiently inactivate gastric enzymes. Nonacid reflux, specifically nonacid pepsin, contributes to carcinogenesis in the larynx. Given the carcinogenic potential of pepsin and inefficacy of PPIs to prevent EAC, the presence and effect of pepsin in the esophagus should be investigated. METHODS: Normal and Barrett's biopsies from 8 Barrett's esophagus patients were collected for pepsin analysis via Western blot and reverse transcriptase-polymerase chain reaction (RT-PCR)...
November 2015: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/26032153/control-of-acid-and-duodenogastroesophageal-reflux-dger-in-patients-with-barrett-s-esophagus
#19
Patrick Yachimski, Sabba Maqbool, Yasser M Bhat, Joel E Richter, Gary W Falk, Michael F Vaezi
OBJECTIVES: Symptom eradication in patients with Barrett's esophagus (BE) does not guarantee control of acid or duodenogastroesophageal reflux (DGER). Continued reflux of acid and/or DGER may increase risk of neoplastic progression and may decrease the likelihood of columnar mucosa eradication after ablative therapy. To date, no study has addressed whether both complete acid and DGER control is possible in patients with BE. This prospective study was designed to assess the effect of escalating-dose proton pump inhibitor (PPI) therapy on esophageal acid and DGER...
August 2015: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/26021202/the-effect-of-proton-pump-inhibitors-on-barrett-s-esophagus
#20
REVIEW
Kerry B Dunbar, Rhonda F Souza, Stuart J Spechler
Proton pump inhibitors (PPIs) may protect against carcinogenesis in Barrett's esophagus because they eliminate the chronic esophageal inflammation of reflux esophagitis, and because they decrease esophageal exposure to acid, which can cause cancer-promoting DNA damage and increase proliferation in Barrett's metaplasia. Most clinical studies of PPIs and cancer development in Barrett's esophagus have found a cancer-protective effect for these drugs, although there are some contradictory data. Chemoprevention of dysplasia and cancer in Barrett's esophagus with PPIs appears to be cost-effective, and the indirect evidence supporting a cancer-protective role for PPIs is strong enough to warrant PPI treatment of virtually all patients with Barrett's esophagus...
June 2015: Gastroenterology Clinics of North America
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