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https://www.readbyqxmd.com/read/29045075/immunocytochemistry-for-sox-11-and-tfe3-as-diagnostic-markers-for-solid-pseudopapillary-neoplasms-of-the-pancreas-in-fna-biopsies
#1
Wen-Chi Foo, Grant Harrison, Xuefeng Zhang
BACKGROUND: Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare malignant tumors that can be sampled via endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). Although diagnosing SPNs can be straightforward in cases with a classic morphology and a typical immunoprofile, challenges can occur with morphologic variants or limited specimens. Recently, 2 immunohistochemical stains, SRY-related high-mobility group box 11 (SOX-11) and transcription factor E3 (TFE3), have been demonstrated to be highly sensitive and specific for SPNs in pancreatic resection specimens...
October 16, 2017: Cancer
https://www.readbyqxmd.com/read/29044714/definition-and-classification-of-evaluation-units-for-tertiary-structure-prediction-in-casp12-facilitated-through-semi-automated-metrics
#2
Luciano A Abriata, Lisa N Kinch, Giorgio E Tamò, Bohdan Monastyrskyy, Andriy Kryshtafovych, Matteo Dal Peraro
For assessment purposes, CASP targets are split into evaluation units. We herein present the official definition of CASP12 evaluation units (EUs) and their classification into difficulty categories. Each target can be evaluated as one EU (the whole target) or/and several EUs (separate structural domains or groups of structural domains). The specific scenario for a target split is determined by the domain organization of available templates, the difference in server performance on separate domains versus combination of the domains, and visual inspection...
October 16, 2017: Proteins
https://www.readbyqxmd.com/read/29043580/a-comprehensive-assessment-of-accurate-lymph-node-staging-and-preoperative-detection-in-resected-pancreatic-cancer
#3
Toshiro Masuda, Amanda M Dann, Irmina A Elliott, Hideo Baba, Stephen Kim, Alireza Sedarat, V Raman Muthusamy, Mark D Girgis, O Joe Hines, Howard A Reber, Timothy R Donahue
BACKGROUND: The current (seventh edition) American Joint Commission on Cancer (AJCC) Staging System for pancreatic ductal adenocarcinoma (PDAC) dichotomizes pathologic lymph node (LN) involvement into absence (pN0) or presence (pN1) of disease. The recently announced eighth edition also includes stratification on the number of positive nodes. Furthermore, LNs detected on preoperative imaging (CT, MRI, or endoscopic ultrasound-EUS) are considered to be pathologically involved in other gastrointestinal cancers...
October 17, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29041017/single-session-eus-guided-hepaticogastrostomy-and-dual-scope-gastroenterostomy-a-modified-technique-for-palliative-double-endoscopic-biliary-and-gastric-bypass
#4
Manuel Alejandro Mahler, Robin German Prieto, Inés Oria, Guido Villa-Gómez, Gustavo Vidales, Manuel Perez-Miranda
No abstract text is available yet for this article.
October 17, 2017: Endoscopy
https://www.readbyqxmd.com/read/29040894/demystifying-endoscopic-retrograde-cholangiopancreatography-ercp-during-pregnancy
#5
REVIEW
Vítor Magno-Pereira, Pedro Moutinho-Ribeiro, Guilherme Macedo
BACKGROUND: For many years, ERCP was avoided in pregnancy given the concerns regarding the adverse effects that, with special focus on radiation, could occur in the developing fetus. However, the postponement or rejection of ERCP in pregnant women, may lead to a higher risk for mother and fetus, especially when the indication is unequivocal, namely cholangitis, biliary pancreatitis and symptomatic choledocholithiasis. SUMMARY AND KEY MESSAGES: This review aims to summarize the scarce literature on the subject in order to plan ERCP in pregnancy with the highest safety...
October 8, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29034764/indeterminate-biliary-strictures-a-simplified-approach
#6
Chencheng Xie, Khalil Aloreidi, Bhavesh Patel, Timothy Ridgway, Thavam Thambi-Pillai, Gary Timmerman, Adeel Khan, Muslim Atiq
Pre-operative evaluation of biliary strictures remains challenging. The dilemma that exists is how to balance the risk of failing to detect malignancy and the potential morbidity caused by unnecessary surgery in patients with benign etiologies. With emerging novel diagnostic modalities, this study aims to assess the efficacy of diagnostic techniques and facilitate a clinical approach to indeterminate biliary strictures. Areas covered: Conventional imaging modalities are crucial in identifying the location of a stricture and are helpful for choosing further diagnostic modalities...
October 16, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29033431/diagnostic-challenge-in-pancreatic-sarcoidosis-using-endoscopic-ultrasonography
#7
Nobuaki Azemoto, Teru Kumagi, Mitsuhito Koizumi, Taira Kuroda, Hirofumi Yamanishi, Yoshinori Ohno, Yoshiki Imamura, Eiji Takeshita, Yoshiko Soga, Yoshiou Ikeda, Morikazu Onji, Yoichi Hiasa
We herein report a 55-year-old woman who presented with erythema and bilateral hilar lymphadenopathy 4 months prior to the detection of pancreatic lesions on an ultrasound. A skin biopsy showed evidence of sarcoidosis. The largest lesion in the tail of the pancreas was hypoechoic on endoscopic ultrasonography (EUS). The lesion was initially iso-enhanced on contrast enhanced-EUS (CE-EUS) but subsequently became hypoenhanced. The lesion revealed heterogeneous components of both soft and hard tissue on EUS elastography...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29032609/usefulness-of-endoscopic-ultrasonography-elastography-as-a-predictive-tool-for-the-occurrence-of-pancreatic-fistula-after-pancreatoduodenectomy
#8
Takamichi Kuwahara, Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Yukihiro Yokoyama, Tsutomu Fujii, Shigeo Nakamura, Yasuhiro Kodera, Masato Nagino, Hidemi Goto
BACKGROUND: Pancreatic fistula (PF) is a major complication following pancreatoduodenectomy (PD). Pancreatic texture is a risk factors for PF, but its evaluation depends on the subjective judgment. The aim of this study was to investigate whether preoperative endoscopic ultrasonography-elastography (EUS-EG), which objectively assesses tissue elasticity, predict the development of PF following PD. METHODS: Fifty-nine patients who underwent EUS-EG before PD and had pancreas parenchyma histologically evaluated were included...
October 15, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29031414/the-application-of-ultrasound-elastography-in-the-shoulder
#9
REVIEW
Jonas Schmalzl, Annabel Fenwick, Dirk Boehm, Fabian Gilbert
Ultrasound elastography (EUS) is a recently developed method for the assessment of tissue elasticity by applying mechanical stress and subsequently analyzing tissue displacement with ultrasound. To date, mainly two different techniques are used in clinical practice: strain (compression) EUS and shear wave EUS. However, shear wave EUS has been shown to be more examiner independent and more reliable as this technique allows a quantitative measurement of tissue elasticity. There is increasing evidence that EUS can be used to evaluate mechanical properties of musculoskeletal tissue...
October 11, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29030002/an-unusual-cause-of-bowel-obstruction-diagnosed-by-eus
#10
Juliana Pinho, Ana Luis, Pedro Bastos
No abstract text is available yet for this article.
October 10, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29029521/contrast-enhanced-endoscopic-ultrasound-for-differential-diagnosis-of-pancreatic-cancer-an-updated-meta-analysis
#11
Xing-Kang He, Yue Ding, Lei-Min Sun
AIM: We aim to assess the diagnostic value of contrast-enhanced endoscopic ultrasound (CE-EUS) for pancreatic cancer and inflammatory lesions by pooling current evidence. MATERIALS AND METHODS: A systematical search of PubMed, Web of Science and the Cochrane Library was performed from inception to January 2016. Two authors independently screened and extracted detailed data from included studies. A random effect model was adopted to estimate the pooled sensitivity, specificity in order to determine the diagnostic ablitity of CE-EUS...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29026599/comparison-of-pancreatic-histology-specimens-obtained-by-eus-19g-versus-22g-core-biopsy-needles-a-prospective-multicentre-study-among-experienced-pathologists
#12
Maria Chiara Petrone, Jan-Werner Poley, Matteo Bonzini, Ihab Abdulkader, Katharina Biermann, Genevieve Monges, Guido Rindi, Claudio Doglioni, Marco J Bruno, Marc Giovannini, Julio Iglesias-Garcia, Alberto Larghi, Paolo Giorgio Arcidiacono
BACKGROUND AND AIM: Scanty data about inter-observer agreement (IOA) among pathologists in the evaluation of pancreatic samples acquired with EUS histology needle are available. The aim of this study was to determine IOA on adequacy of pancreatic histology specimens obtained with a 22G needle by a panel of experienced pathologist, in comparison with the 19G needle. METHODS: This multicentre prospective study involved 73 pancreatic specimens prepared using histology needles of different calibres...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29024704/eus-guided-pancreatic-pseudoaneurysm-therapy-better-to-be-lucky-than-good
#13
Kayin Jeffers, Shounak Majumder, Santhi Swaroop Vege, Michael Levy
No abstract text is available yet for this article.
October 9, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29021470/eus-guided-biliary-drainage-for-malignant-perihilar-biliary-strictures-after-further-transpapillary-intervention-has-been-judged-to-be-impossible-or-ineffective
#14
Yoshihide Kanno, Kei Ito, Shinsuke Koshita, Takahisa Ogawa, Kaori Masu, Hiroaki Kusunose, Toshitaka Sakai, Yoshiharu Masaki, Toji Murabayashi, Sho Hasegawa, Fumisato Kozakai, Jun Horaguchi, Hidenori Matsuo, Yutaka Noda
Objective Patients with perihilar malignancy often develop recurrence of infectious cholangitis, which makes further transpapillary intervention extremely difficult. As EUS-guided biliary drainage (EUS-BD) of an intrahepatic bile duct is a possible option for additional intervention, the aim of this study was to estimate the feasibility of such intervention. Methods and Patients Patients who had undergone EUS-BD after further transpapillary intervention was deemed impossible or ineffective were investigated in this study...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28988195/eus-guided-fine-needle-biopsy-of-pancreatic-masses-can-yield-true-histology-results-of-a-randomised-trial
#15
Ji Young Bang, Shantel Hebert-Magee, Udayakumar Navaneethan, Muhammad K Hasan, Robert Hawes, Shyam Varadarajulu
No abstract text is available yet for this article.
October 7, 2017: Gut
https://www.readbyqxmd.com/read/28983771/endoscopic-and-imaging-predictors-of-complete-pathologic-response-after-chemoradiation-for-esophageal-cancer
#16
REVIEW
Guneesh S Uberoi, Angad S Uberoi, Manoop S Bhutani
PURPOSE OF REVIEW: Locally advanced esophageal cancer is frequently treated preoperatively with chemotherapy and radiation. The degree of response to this preoperative therapy varies in different patients, and a complete pathological response (pCR) has important implications in the management and prognosis of these patients. This is a review of the different modalities currently available to detect pCR and the clinical context of their use. RECENT FINDINGS: While research is still ongoing, no single technique has emerged as the modality of choice to reliably predict pCR in all patients...
October 6, 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28983505/comparison-of-endoscopic-ultrasound-guided-fine-needle-aspiration-by-capillary-action-suction-and-no-suction-methods-a-randomized-blinded-study
#17
Rinkesh K Bansal, Narendra S Choudhary, Rajesh Puri, Saurabh K Patle, Suraj Bhagat, Mukesh Nasa, Amit Bhasin, Haimanti Sarin, Mridula Guleria, Randhir Sud
BACKGROUND AND STUDY AIM : Different types of endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) techniques are used in clinical practice; the best method in terms of outcome has not been determined. The aim of the study was to compare the diagnostic adequacy of aspirated material, and the cytopathological and EUS morphological features between capillary action, suction, and no-suction FNA methods. PATIENTS AND METHODS:  This was a prospective, single-blinded, randomized study conducted at a tertiary care hospital...
October 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28982258/international-study-of-endoscopic-management-of-distal-malignant-biliary-obstruction-combined-with-duodenal-obstruction
#18
Tsuyoshi Hamada, Yousuke Nakai, James Y Lau, Jong Ho Moon, Tsuyoshi Hayashi, Ichiro Yasuda, Bing Hu, Dong-Wan Seo, Hiroshi Kawakami, Masaki Kuwatani, Akio Katanuma, Masayuki Kitano, Shomei Ryozawa, Keiji Hanada, Takuji Iwashita, Yukiko Ito, Hiroshi Yagioka, Osamu Togawa, Iruru Maetani, Hiroyuki Isayama
OBJECTIVE: Endoscopic transpapillary or endoscopic ultrasound (EUS)-guided stent placement is used for nonresectable distal malignant biliary obstruction. We conducted a retrospective study to evaluate endoscopic biliary drainage in patients with duodenal obstruction. METHODS: We included consecutive patients who underwent endoscopic biliary drainage combined with a duodenal stent at 16 referral centers in four Asian countries. The primary outcome was time to recurrent biliary obstruction (TRBO)...
October 6, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28979714/novel-and-supplementary-management-of-pancreatic-fluid-collections-endoscopic-ultrasound-guided-drainage
#19
Si-Jie Hao, Wei-Jia Xu, Yang Di, Lie Yao, Hang He, Feng Yang, Chen Jin, Liang Zhong, De-Liang Fu
AIM: To compare efficacy and safety of endoscopic ultrasound (EUS)-guided and surgical drainage in pancreatic fluid collection management. METHODS: Data were obtained retrospectively from January 2012 to December 2016. Patients with pancreatic fluid collection were performed EUS-guided or surgical procedure. Main outcome measures including clinical efficiency, complication, duration of procedures, hospital stay and cost were analyzed. RESULTS: Thirty-six patients were enrolled into the study, including 14 in endoscopic group while 22 in the surgical group...
September 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28977739/denonvilliers-fascia-in-men-a-sheet-plastination-and-confocal-microscopy-study-of-the-prerectal-space-and-the-presence-of-an-optimal-anterior-plane-when-mobilizing-the-rectum-for-cancer
#20
Zhaoyang Xu, Pierre H Chapuis, Les Bokey, Ming Zhang
AIM: The aim of this study was to investigate the detailed, in situ, morphology of Denonvilliers fascia (DVF) in cadavers using sheet plastination and confocal microscopy and to review and describe the optimal anterior plane for mobilisation of the distal rectum.. METHOD: Six, male cadavers (age range, 46-87 years) were prepared as six sets of transverse (x2), coronal (x1) and sagittal (x3) plastinated sections which were examined under a confocal laser scanning microscope...
October 4, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
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