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Portal thrombosis

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https://www.readbyqxmd.com/read/29928393/higher-expression-of-a-kinase-anchoring-protein-1-predicts-poor-prognosis-in-human-hepatocellular-carcinoma
#1
Jian Yu, Yu Zhang, Dongxun Zhou, Jun Wu, Rong Luo
A-kinase anchoring protein 1 (AKAP1) plays important regulatory roles in the regulation of mitochondrial function, oxidative metabolism, and cell survival. However, the expression pattern and prognostic value of AKAP1 in hepatocellular carcinoma (HCC) remains unclear. AKAP1 expression levels in tumor and matched non-tumor tissues were evaluated using reverse transcription-quantitative polymerase chain reaction and immunohistochemical staining. Kaplan-Meier and Cox regression analyses were used to analyze the survival rates...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29924030/acute-portal-vein-thrombosis-after-hepatectomy-in-a-patient-with-hepatolithiasis-a-case-report-and-review-of-the-literature
#2
Zun-Yi Zhang, Ke-Shuai Dong, Er-Lei Zhang, Zhi-Yong Huang, Xiao-Ping Chen, Han-Hua Dong
RATIONALE: Portal vein thrombosis is defined as any thrombosis that develops in the portal vein system. It is considered a very rare and extremely lethal complication of hepatopancreatobiliary surgery. PATIENT CONCERNS: Acute portal vein thrombosis after hepatectomy in patients with hepatolithiasisis very rare. Acute portal vein thrombosis is considered as a dangerous complication after hepatectomy. It is easy to ignore the symptom of acute portal vein thrombosis...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923164/a-case-of-portal-vein-thrombosis-caused-by-blunt-abdominal-trauma-in-a-patient-with-low-protein-c-activity
#3
Erica Nishimura, Takeyuki Misawa, Hiroaki Kitamura, Shuichi Fujioka, Tadashi Akiba, Katsuhiko Yanaga
Portal vein thrombosis (PVT) is caused by several conditions including infection, malignancies, surgery, medications, and coagulation disorders. However, PVT caused by low-energy injury is very rare. A 51-year-old man visited a clinic with a 2-day history of abdominal pain following blunt abdominal trauma. Contrast-enhanced computed tomography (CT) revealed thrombosis in both the portal vein and splenic vein, and he was transferred to our hospital with a diagnosis of PVT. Anticoagulant therapy was initiated using unfractionated heparin...
June 19, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29916054/anticoagulation-in-non-malignant-portal-vein-thrombosis-is-safe-and-improves-hepatic-function
#4
Bernhard Scheiner, Paul René Stammet, Sebastian Pokorny, Theresa Bucsics, Philipp Schwabl, Andrea Brichta, Johannes Thaler, Katharina Lampichler, Ahmed Ba-Ssalamah, Cihan Ay, Arnulf Ferlitsch, Michael Trauner, Mattias Mandorfer, Thomas Reiberger
BACKGROUND: Non-malignant portal vein thrombosis (PVT) is common in patients with advanced liver disease. Anticoagulation (AC) increases the chances of recanalization and may improve liver function in patients with cirrhosis. AIM: We retrospectively assessed the course of non-malignant PVT in patients receiving AC. METHODS: Parameters related to hepatic injury (aspartate aminotransferase [AST]/alanine aminotransferase [ALT]), severity of disease (ascites) and synthesis function (albumin) as well as AC, rates of PVT regression/progression and AC-associated complications were documented...
June 18, 2018: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/29910857/obesity-is-not-associated-with-an-increased-risk-of-portal-vein-thrombosis-in-cirrhotic-patients
#5
Alan Zakko, Paul T Kroner, Rooma Nankani, Raffi Karagozian
Aim: To determine the impact of obesity on development of portal vein thrombosis in cirrhotic patients. Background: Cirrhosis is a known risk factor for portal vein thrombosis (PVT). Evidence also points to obesity as being a risk factor for venous thromboembolism. Limited information is available on how obesity impacts the development of PVT in cirrhotic patients. Methods: This was a retrospective cohort study using the 2013 National Inpatient Sample...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29909684/hydatid-cyst-of-the-pancreas-causing-both-acute-pancreatitis-and-splenic-vein-thrombosis
#6
O Ozsay, F Gungor, Serkan Karaisli, Ibrahim Kokulu, Osman Nuri Dilek
Hydatid cyst of the pancreas is a rarely seen entity even in endemic countries. Cyst may causes several symptoms due to external compression or fistulisation to pancreaticobiliary tract or small bowel. A 23-year-old female patient was referred with a complaint of abdominal pain. Preoperative imaging revealed an undefined cyst in the tail of pancreas. She underwent distal pancreatectomy and splenectomy, with a diagnosis of acute pancreatitis due to cystopancreatic duct fistula and also left-sided portal hypertension due to splenic vein thrombosis...
June 18, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29904721/surveillance-for-portal-hypertension-in-the-course-of-liver-cirrhosis
#7
REVIEW
Anna Piekarska, Ewa K Berkan, Kamila M Wójcik
Non-invasive liver fibrosis assessment techniques are under development for evaluating the severity of liver disease and portal hypertension. The paper presents practical arrangements for the diagnosis and treatment of portal hypertension in patients with chronic liver disease, established in the Baveno VI Consensus Workshop for diagnosis and treatment of portal hypertension. Currently, the diagnostic standard of liver disease severity is transient elastography, which can identify patients with clinically significant portal hypertension (liver stiffness > 20 kPa)...
June 2018: Clinical and experimental hepatology
https://www.readbyqxmd.com/read/29901488/decrease-in-total-lesion-glycolysis-and-survival-after-yttrium-90-radioembolization-in-poorly-differentiated-hepatocellular-carcinoma-with-portal-vein-tumour-thrombosis
#8
Luca Filippi, Giovan G Di Costanzo, Antonio D'Agostini, Raffaella Tortora, Giuseppe Pelle, Roberto Cianni, Orazio Schillaci, Oreste Bagni
PURPOSE: This study aims to evaluate the prognostic role of the decrease in total lesion glycolysis (TLG) assessed by fluorine-18-fluorodeoxyglucose (F-FDG) PET-computed tomography (CT) 1 month after yttrium-90-radioembolization (Y-RE) in patients affected by hepatocellular carcinoma (HCC) with portal vein tumour thrombosis (PVTT). PATIENTS AND METHODS: Twenty-one patients with histologically proven poorly differentiated HCC and evidence of PVTT at the enhanced multislice CT underwent Y-RE...
June 12, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29892174/living-donor-liver-transplantation-using-small-for-size-grafts-does-size-really-matter
#9
Pulkit Sethi, Manoj Thillai, Binoj Sivasankarapillai Thankamonyamma, Shweta Mallick, Unnikrishnan Gopalakrishnan, Dinesh Balakrishnan, Ramachandran Narayana Menon, Sudhindran Surendran, Puneet Dhar, Sudheer Othiyil Vayoth
Background: In living donor liver transplantation (LDLT), graft-to-recipient weight ratio (GRWR) > 0.8% is perceived as the critical graft size. This lower limit of GRWR (0.8%) has been challenged over the last decade owing to the surgical refinements, especially related to inflow and outflow modulation techniques. Our aim was to compare the recipient outcome in small-for-size (GRWR < 0.8) versus normal-sized grafts (GRWR > 0.8) and to determine the risk factors for mortality when small-for-size grafts (SFSG) were used...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29890295/direct-oral-anticoagulants-and-cirrhosis-more-evidence-still-needed-for-efficacy-and-safety-in-portal-vein-thrombosis
#10
REVIEW
Pier Mannuccio Mannucci, Armando Tripodi
No abstract text is available yet for this article.
June 8, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29886667/-postoperative-complications-and-survival-analysis-of-1-118-cases-of-open-splenectomy-and-azygoportal-disconnection-in-the-treatment-of-portal-hypertension
#11
R Z Qi, X Zhao, S Z Wang, K Zhang, Z Y Chang, X L Hu, M L Wu, P R Zhang, L X Yu, C H Xiao, X J Shi, Z W Li
Objective: To analyze the recent postoperative and long-term postoperative complications of open-splenectomy and disconnection in patients with portal hypertension. Methods: There were 1 118 cases with portal hypertension who underwent open splenectomy and azygoportal disconnection from April 2010 to September 2015 at Department of Surgery, People's Liberation Army 302 Hospital. Retrospective case investigation and telephone follow-up were conducted in October 2016. All patients had history of upper gastrointestinal bleeding before operation...
June 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29886103/randomized-controlled-trial-of-rivaroxaban-versus-warfarin-in-the-management-of-acute-non-neoplastic-portal-vein-thrombosis
#12
Amr Shaaban Hanafy, Sherief Abd-Elsalam, Mohammed M Dawoud
BACKGROUND AND AIM: Anticoagulation therapy is the main line of treatment for acute portal vein thrombosis (PVT) in the absence of cirrhosis. However, the use of this therapy in cirrhotic PVT is still with doubtful evidence. We aimed to evaluate the efficacy and safety of rivaroxaban compared to warfarin for the management of acute non-neoplastic PVT in Hepatitis C virus (HCV)-related compensated cirrhosis. METHODS: Out of 578 patients with chronic HCV infection, 80 patients with acute PVT who had undergone splenectomy due to hypersplenism and 4 patients with acute PVT due to portal pyemia were selected...
June 7, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29884476/hepatocyte-spheroids-as-an-alternative-to-single-cells-for-transplantation-after-ex-vivo-gene-therapy-in-mice-and-pig-models
#13
Clara T Nicolas, Raymond D Hickey, Kari L Allen, Zeji Du, Rebekah M Guthman, Robert A Kaiser, Bruce Amiot, Aditya Bansal, Mukesh K Pandey, Lukkana Suksanpaisan, Timothy R DeGrado, Scott L Nyberg, Joseph B Lillegard
BACKGROUND: Autologous hepatocyte transplantation after ex vivo gene therapy is an alternative to liver transplantation for metabolic liver disease. Here we evaluate ex vivo gene therapy followed by transplantation of single-cell or spheroid hepatocytes. METHODS: Pig and mouse hepatocytes were isolated, labeled with zirconium-89 and returned to the liver as single cells or spheroids. Biodistribution was evaluated through positron emission tomography-computed tomography...
June 5, 2018: Surgery
https://www.readbyqxmd.com/read/29879466/a-paradoxical-thrombogenic-mutation-in-factor-ii-at-the-target-site-of-arthropod-bleeding-toxin
#14
Toshiki Takenouchi, Hiroyuki Shimada, Tomoko Uehara, Yae Kanai, Takao Takahashi, Kenjiro Kosaki
Loss-of-function mutations in coagulation cascade proteins lead to bleeding diasthesis. In contrast, gain-of-function mutations in these proteins, which are exceptionally rare, lead to hereditary thrombosis. This is best exemplified by Factor V (i.e., Factor V Leiden) and Factor II (i.e., p.Arg596Leu). Here, we report a family with hereditary thrombosis. The proposita presented with cerebral venous thrombosis accompanied by infarction at the age of 12 years. Despite anticoagulation therapy with oral warfarin, she later developed deep venous thrombosis in her hepatic portal veins at the age of 27 years...
June 4, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29875989/extensive-thrombus-and-brain-microabscesses-after-sleeve-gastrectomy
#15
Grace Faith Chao, Sameer Hirji, Scott Alan Shikora
Sleeve gastrectomy is a relatively newer bariatric surgical procedure and has become the most common of all bariatric surgeries performed. Complication rates reported with sleeve gastrectomies are relatively low and are generally due to staple line leaks, hemorrhage, or sleeve stricture. Portal vein thrombosis is an uncommon but potentially dangerous complication. We present a case of a 21-year-old woman who developed thrombosis of the portal, splenic, and right common iliac veins that then resulted in multifocal brain abscesses from presumed Fusobacterium septic emboli following an uncomplicated laparoscopic sleeve gastrectomy...
March 2018: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/29874983/plasma-cholesterol-and-lipoprotein-levels-in-relation-to-tumor-aggressiveness-and-survival-in-hcc-patients
#16
Brian I Carr, Gianluigi Giannelli, Vito Guerra, Edoardo G Giannini, Fabio Farinati, Gian Ludovico Rapaccini, Maria Di Marco, Marco Zoli, Eugenio Caturelli, Alberto Masotto, Roberto Virdone, Rodolfo Sacco, Franco Trevisani
BACKGROUND AND AIMS: Hepatocellular carcinoma is associated with several chronic liver diseases, especially chronic hepatitis B virus, hepatitis C virus, and alcoholism. It is increasingly appreciated that obesity/metabolic syndrome is also associated with chronic liver disease and subsequent hepatocellular carcinoma. METHODS: We retrospectively investigated the serum lipid profiles in a large hepatocellular carcinoma cohort, associated predominantly with the hepatitis B virus, hepatitis C virus, alcohol or nonalcoholic steatohepatitis...
June 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29871683/transient-portal-vein-thrombosis-in-liver-cirrhosis
#17
REVIEW
Xingshun Qi, Xiaozhong Guo, Eric M Yoshida, Nahum Méndez-Sánchez, Valerio De Stefano, Frank Tacke, Andrea Mancuso, Yasuhiko Sugawara, Sien-Sing Yang, Rolf Teschke, Ankur Arora, Dominique-Charles Valla
In real-world clinical practice, the acceptance of anticoagulation therapy in the management of portal vein thrombosis (PVT) in patients with cirrhosis is limited by the fear of an increased bleeding risk. Additionally, accumulating evidence indicates that spontaneous recanalization of PVT may occur in the absence of antithrombotic treatment. Therefore, risk stratification based on outcomes in such patients is crucial for determining a therapeutic strategy. In this paper, we draw attention to the distinct clinical entity, "transient PVT" by introducing two cases with PVT that spontaneously recanalized in the absence of antithrombotic treatment...
June 5, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29869173/impact-of-dual-energy-ct-post-processing-to-differentiate-venous-thrombosis-from-iodine-flux-artefacts
#18
Jakob Weiss, Christoph Schabel, Ahmed E Othman, Georg Bier, Konstantin Nikolaou, Fabian Bamberg, Malte N Bongers
OBJECTIVES: To investigate the accuracy of dual-energy (DE) CT-based iodine maps (IM) and noise-optimised monoenergetic extrapolations (MEI+) at 40 keV for the detection and differentiation of venous thrombosis (VT) from iodine flux artefacts (IFA) in comparison to portal-venous phase CT (CTPV ). METHODS: Ninety-nine patients were enrolled in this study. In all patients, VT or IFA was suspected on contrast-enhanced CT and confirmed by follow-up CT or colour-coded ultrasound...
June 4, 2018: European Radiology
https://www.readbyqxmd.com/read/29863456/application-of-pediatric-donor-livers-after-circulatory-death-in-adult-liver-transplantation-a-single-center-experience
#19
Rui Zhang, Zhi-Jun Zhu, Li-Ying Sun
OBJECTIVES: This study aimed to investigate the outcomes of adult liver transplant procedures using grafts from pediatric donors after circulatory death. MATERIALS AND METHODS: We retrospectively analyzed the data of 19 pediatric-to-adult liver transplant procedures from July 2013 to May 2016 in our hospital. Nineteen adult liver transplant procedures were performed using livers from pediatric donors after circulatory death. RESULTS: We performed 18 orthotopic and 1 piggyback liver transplant procedure...
June 1, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29851765/-acute-variceal-bleeding-causes-significant-morbidity
#20
Marta Carneiro de Moura, Shiyi Chen, Binita M Kamath, Vicky Lee Ng, Simon C Ling
BACKGROUND AND AIMS: The need for primary prophylaxis of variceal bleeding in children is unclear due to insufficient evidence of the efficacy of prophylactic therapy and the mortality and morbidity associated with the first bleeding event. Previous studies have provided estimates of mortality. We aimed to investigate the morbidity associated with acute variceal bleeding (AVB) in children and to identify contributing factors. METHODS: We retrospectively reviewed children with chronic liver disease or portal vein thrombosis admitted with acute upper gastrointestinal bleeding between 2000 and 2015...
May 30, 2018: Journal of Pediatric Gastroenterology and Nutrition
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