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https://www.readbyqxmd.com/read/29663585/perioperative-anticoagulation-practices-for-pediatric-liver-transplantation
#1
Stylianos Voulgarelis, Bernadette Vitola, Stacee M Lerret, Johnny C Hong, John P Scott
Despite continued advancements in perioperative care for pediatric liver transplant (LT), graft-threatening vascular occlusion events including hepatic artery thrombosis (HAT) and portal vein thrombosis (PVT) remain a source of significant morbidity and mortality. Perioperative anticoagulation is commonly used for the prevention of HAT and PVT, but evidence-based guidelines are lacking. The goals of this survey were to determine the frequency of use of an anticoagulation protocol and to describe variation in anticoagulation practices among pediatric LT centers...
April 16, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29661433/better-selection-criteria-with-prognostic-factors-for-liver-transplantation
#2
L S Nacif, R S Pinheiro, V Rocha-Santos, V M Barbosa, A P de Moura Dias, R B Martino, R A Macedo, L Ducatti, L Haddad, F Galvão, W Andraus, L Carneiro D' Albuquerque
BACKGROUND: Liver transplantation has evolved significantly in recent years, with each advancement part of the effort toward increasing patient and graft survival as well as quality of life. The objective of this study was to evaluate the prognostic factors and selection criteria for liver transplantation. METHODS: Our study was a statistical analysis, logistic regression, and survival evaluation of a total of 80 liver transplants that were performed between June 1, 2016 and September 24, 2016...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29661431/stratifying-mortality-in-a-model-for-end-stage-liver-disease-waiting-list-a-brazilian-single-center-study
#3
R B Martino, D R Waisberg, A P M Dias, V B S Inoue, R M Arantes, L B P Haddad, W Andraus, L D Lopes, F H F Galvão, A T W Song, L A C D'Albuquerque
BACKGROUND: The Model for End-Stage Liver Disease (MELD) system reliably predicts mortality in cirrhotic patients. However, the etiology of liver disease and presence of portal vein thrombosis are not directly taken into account in MELD score. Its impact on the outcomes of patients on the waiting list is still unclear. The aim of this study was to investigate mortality and access to transplantation regarding etiology of liver disease and portal vein thrombosis (PVT). METHODS: A total of 465 adult patients on the liver waiting list from August 2015 to August 2016 were followed up until August 2017...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29657612/deal-a-death-blow-hcc-in-cirrhotics-thrombotic-complications-their-frequency-characteristics-and-risk-factors
#4
Khalid Mahmood, Iftikhar Haider Naqvi, Aamer Mahmood, Syed Muhammad, Noor Muhammad
Introduction: The hepatocellular carcinoma (HCC), being the commonest primary cancer, holds the sixth slot in the list of common cancers worldwide. Thrombotic complications in the form of portal vein tumour thrombosis (PVTT) and bland portal vein thrombosis with HCC are common with a bad prognosis. Aim: The study aims to determine the demographic, clinical, and biochemical parameters of HCC patients. The study also compares the clinical and biochemical parameters among patients having HCC with and without thrombotic complication...
2018: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29656412/liver-doppler-findings-in-pediatric-patients-after-total-pancreatectomy-and-islet-autotransplantation
#5
Tara L Holm, Michael A Murati, Eric Hoggard, Lei Zhang, Kelly R Dietz
OBJECTIVES: This study was intended to establish normal values for velocities in the hepatic artery and portal veins in pediatric patients after total pancreatectomy and islet autotransplantation (TPIAT). METHODS: A retrospective review was performed of liver Doppler studies in pediatric patients after TPIAT over 6 years at an academic children's hospital. Doppler velocities in the liver vasculature and the hepatic artery resistive index were recorded. RESULTS: Sixty-five pediatric patients were evaluated...
April 15, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29644531/splanchnic-vein-thrombosis-in-the-myeloproliferative-neoplasms
#6
REVIEW
Imo J Akpan, Brady Lee Stein
PURPOSE OF REVIEW: To review the epidemiology, diagnostic challenges, pathogenesis, and treatment strategies for patients with myeloproliferative neoplasm-associated splanchnic vein thrombosis. RECENT FINDINGS: The epidemiology of myeloproliferative neoplasm-associated splanchnic vein thrombosis (MPN-SVT) has been well characterized. While typical MPN-associated thrombosis affects older patients and involves the arterial circulation, MPN-SVT mostly impacts younger women...
April 11, 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29624817/fatal-hyperammonemia-associated-with-disseminated-serratia-marcescens-infection-in-a-pediatric-liver-transplant-recipient
#7
Stephen Mouat, Jonathan Bishop, Emma Glamuzina, Simon Chin, Emma J Best, Helen M Evans
Hyperammonemia is a rare and important complication post-liver transplantation. We review a case of a 5-month-old boy with biliary atresia who received a split liver transplant following a variceal bleed. The transplant was complicated by recurrent portal vein thrombosis. Colonized with Serratia marcescens pretransplant, he developed disseminated infection associated with very high levels of ammonia that led to his death. It is important to be aware of serum ammonia levels in patients with portal vein thrombosis, particularly in the setting of gastrointestinal bleeding and sepsis...
April 6, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29620156/expression-and-clinical-significance-of-pd%C3%A2-1-in-hepatocellular-carcinoma-tissues-detected-by-a-novel-mouse-anti-human-pd%C3%A2-1-monoclonal-antibody
#8
Ziwei Li, Bin Li, Dan Peng, Haiyan Xing, Guanying Wang, Pan Li, Jiming Wang, George Ye, Jianhong Chen
Hepatocellular carcinoma (HCC) is one of the most common malignancies and causes of death worldwide. Research investigating novel therapeutic strategies for the treatment of HCC is urgently required. Monoclonal antibodies (mAbs) that target the programmed cell death‑1 (PD‑1/PDCD1)/programmed death-ligand 1 (PD-L1) immune checkpoint have demonstrated substantial clinical benefit for a variety of solid tumors; however, these mAbs have not been well studied in HCC. In the present study, Sp2/0-Ag14 myeloma cells and spleen cells derived from BALB/c mice immunized with the recombinant human PD‑1/PDCD1 protein were fused for the production of novel antibodies...
April 4, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29619421/influence-of-spontaneous-splenorenal-shunts-on-clinical-outcomes-in-decompensated-cirrhosis-and-after-liver-transplantation
#9
Karen Saks, Kyle K Jensen, Joel McLouth, Justine Hum, Joseph Ahn, Atif Zaman, Michael F Chang, Alice Fung, Barry Schlansky
Cirrhosis and portal hypertension can lead to the formation of a spontaneous splenorenal shunt (SSRS) that may divert portal blood flow to the systemic circulation and reduce hepatic perfusion. Our aims were to evaluate SSRSs as an independent prognostic marker for mortality in patients with decompensated cirrhosis and the influence of SSRSs on liver transplantation (LT) outcomes. We retrospectively analyzed adult patients with decompensated cirrhosis undergoing LT evaluation from January 2001 to February 2016 at a large U...
April 2018: Hepatology communications
https://www.readbyqxmd.com/read/29616318/re-transplantation-for-hepatic-artery-thrombosis-a-national-perspective
#10
Shu Kwun Lui, Catherine R Garcia, Xiaonan Mei, Roberto Gedaly
BACKGROUND: Hepatic artery thrombosis (HAT) is a major complication after liver transplantation that commonly requires re-transplantation. METHODS: We queried the UNOS dataset for all patients transplanted between 1995 and 2015 for HAT. RESULTS: We identified 623 patients who underwent re-transplantation for HAT with a mean age of 51.25 + 10.4 years. The mean BMI was 26.72 kg/m2 , and mean MELD score was 19.62 + 9.09. There was a higher proportion of male patients, with higher prevalence of pre-transplant portal vein thrombosis (7...
April 3, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29614589/-two-cases-report-of-bone-marrow-hyperplastic-tumor-combined-with-portal-spongy-degeneration-presenting-with-portal-vein-thrombosis-and-portal-venous-hypertension
#11
X Li, P J Gao
No abstract text is available yet for this article.
April 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29611180/antimicrobial-lock-solutions-for-preventing-catheter-related-infections-in-haemodialysis
#12
REVIEW
Maria C Arechabala, Maria I Catoni, Juan Carlos Claro, Noelia P Rojas, Miriam E Rubio, Mario A Calvo, Luz M Letelier
BACKGROUND: Patients undergoing haemodialysis (HD) through a central venous catheter (CVC) are exposed to several risks, being a catheter-related infection (CRI) and a CVC lumen thrombosis among the most serious. Standard of care regarding CVCs includes their sealing with heparin lock solutions to prevent catheter lumen thrombosis. Other lock solutions to prevent CRI, such as antimicrobial lock solutions, have proven useful with antibiotics solutions, but not as yet for non-antibiotic antimicrobial solutions...
April 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29607298/timing-of-the-treatment-of-portal-vein-thrombosis-in-patients-with-cirrhosis-a-german-hepatologist-s-perspective
#13
Martin Rössle, Michael Schultheiss
No abstract text is available yet for this article.
March 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29607297/timing-of-anticoagulation-for-portal-vein-thrombosis-in-liver-cirrhosis-an-italian-internist-s-perspective
#14
Nicoletta Riva, Walter Ageno
No abstract text is available yet for this article.
March 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29607296/timing-of-anticoagulation-for-portal-vein-thrombosis-in-liver-cirrhosis-a-us-hepatologist-s-perspective
#15
Patrick G Northup, Jessica P E Davis
No abstract text is available yet for this article.
March 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29600476/percutaneous-transhepatic-intrahepatic-portosystemic-shunt-for-variceal-bleeding-with-chronic-portal-vein-occlusion-after-splenectomy
#16
Junyang Luo, Mingan Li, Youyong Zhang, Haofan Wang, Mingsheng Huang, Zhengran Li, Junwei Chen, Chun Wu, Jiesheng Qian, Shouhai Guan, Zaibo Jiang
OBJECTIVES: The purpose of this study was to introduce a modified transjugular intrahepatic portosystemic shunt (TIPS), a percutaneous transhepatic intrahepatic portosystemic shunt (PTIPS), and to evaluate its feasibility and efficacy in patients with variceal bleeding with chronic portal vein occlusion (CPVO) after splenectomy. METHODS: Twenty-four cirrhotic patients with CPVO after splenectomy who received PTIPS between 2010 and 2015 were included in this retrospective study...
March 29, 2018: European Radiology
https://www.readbyqxmd.com/read/29594198/hepatic-infarction-and-acute-pancreatitis-a-case-report-and-review-of-the-literature
#17
Archana Kulkarni, Hamza Arif, Manik Veer, Kateyln Ziggas, Amit Kaura, Meera Sareen
Hepatic infarction is rare due to the unique dual hepatic blood supply from the hepatic artery and the portal vein. Herein, we report a case of hepatic infarction that occurred as a complication of acute pancreatitis. The patient was a 58-year-old male with past medical history of chronic alcoholism, who presented with epigastric abdominal pain, nausea, and vomiting. Hepatic infarction was diagnosed with computed tomography of the abdomen and pelvis without contrast, which revealed suspicion of splenic vein thrombosis and peripancreatic fat stranding along with a wedge-shaped, peripheral hypo density in the right hepatic lobe with typical morphology for hepatic infarction...
March 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29593928/extra-anatomic-jump-graft-from-the-right-colic-vein-a-novel-technique-to-manage-portal-vein-thrombosis-in-liver-transplantation
#18
Paolo Magistri, Giuseppe Tarantino, Tiziana Olivieri, Annarita Pecchi, Roberto Ballarin, Fabrizio Di Benedetto
Background: In the context of cirrhosis, portal vein thrombosis (PVT) is present in 2.1% to 26% of patients. PVT is no longer considered an absolute contraindication for liver transplantation, and nowadays, surgical strategies depend on the extent of PVT. Complete PVT is associated with higher morbidity rates and poor prognosis, while comparable long-term outcomes can be achieved as long as physiological portal inflow is restored. Materials and Methods: We report our experience with a 45-year-old patient undergoing liver transplant with a PVT (stage III-b)...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29577520/the-impact-of-thromboelastography-on-resuscitation-in-pediatric-liver-transplantation
#19
Joseph Sujka, Katherine W Gonzalez, Kayla L Curiel, James Daniel, Ryan T Fischer, Walter S Andrews, Brian M Wicklund, Richard J Hendrickson
Although TEG directs effective resuscitation in adult surgical patients, pediatric data are lacking. We performed a retrospective comparative review of the effect of TEG on blood product utilization and outcomes following pediatric liver transplantation in 38 patients between 2008 and 2014. Diagnoses, laboratory values, fluid and blood product use, and outcomes were examined. Nineteen patients underwent liver transplantation prior to the implementation of TEG, and 19 had perioperative TEG. The most common indications for transplant were BA (n = 14), HB (n = 7), and metabolic disorders (n = 7)...
March 26, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29572884/transient-elastography-is-an-unreliable-marker-of-liver-fibrosis-in-patients-with-portal-vein-thrombosis
#20
Ruiyao Huang, Zu-Hua Gao, An Tang, Giada Sebastiani, Marc Deschenes
No abstract text is available yet for this article.
March 23, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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