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Portal thrombosis

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https://www.readbyqxmd.com/read/29451181/the-use-of-nonselective-beta-blockers-is-a-risk-factor-for-portal-vein-thrombosis-in-cirrhotic-patients
#1
Rosa Zampino, Rita Lebano, Nicola Coppola, Margherita Macera, Anna Grandone, Luca Rinaldi, Ilario De Sio, Antonella Tufano, Gianfranca Stornaiuolo, Luigi E Adinolfi, Emanuele Durante-Mangoni, Gaeta G Battista, Alferio Niglio
Background/Aim: A reduction in portal vein inflow velocity seems to predispose to the emergence of portal vein thrombosis (PVT). Nonselective β-blockers (NSBBs), used to prevent variceal bleeding, may increase the development of PVT by reducing portal vein inflow velocity. In this retrospective case-control study, we evaluated the risk factors and clinical features of a first event of PVT in 130 cirrhotics, 19 (15%) with (PVT group) and 111 (85%) without PVT (non-PVT group). Patients and Methods: Patient evaluation and NNBB treatment were carried out according to the AASLD guidelines...
January 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29451177/the-association-between-nonselective-beta-blockers-and-portal-venous-thrombosis-in-cirrhotic-patients-more-questions-on-the-horizon
#2
EDITORIAL
Nicholas Bartell, Bandar Al-Judaibi
No abstract text is available yet for this article.
January 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29441227/pancreaticoportal-fistula-formation-as-a-consequence-of-recurrent-acute-pancreatitis-clinical-and-imaging-considerations
#3
Mina S Makary, Edward L Gayou, Douglas Kyrouac, Zarine K Shah
A pancreatic-portal vein fistula (PPVF) is an extremely rare complication of pancreatitis. In this report, we present a patient with a PPVF in the setting of recurrent pancreatitis and portal vein thrombosis diagnosed by cross-sectional imaging and endoscopic retrograde cholangio-pancreatography, who responded to medical management and anticoagulation. A critical review of this disease process is explored to highlight pathology, imaging characteristics, and essential alternative diagnostic considerations. We also discuss potential complications and current treatment strategies...
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29439833/-ascites-as-first-manifestation-of-superior-mesenteric-and-portal-vein-thrombosis-secondary-to-protein-s-deficiency
#4
Nieves Parras García de León, Georgina Martinón Torres, José Luis Esquinas Requena, Jacinta Martín Márquez, Rosa Muñiz Alonso
No abstract text is available yet for this article.
February 10, 2018: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29439255/co-upregulation-of-14-3-3%C3%AE-and-p-akt-is-associated-with-oncogenesis-and-recurrence-of-hepatocellular-carcinoma
#5
Yufu Tang, Ruoyu Wang, Yibing Zhang, Shenhui Lin, Na Qiao, Zhongyi Sun, Shuqun Cheng, Wenping Zhou
BACKGROUND/AIMS: 14-3-3ζ is involved in the regulation of PI3K/Akt pathway which is closely associated with carcinogenesis. However, the clinical significance of combined detection of 14-3-3ζ and p-Akt in hepatocellular carcinoma (HCC) remains unclear. METHODS: Two-hundred pairs of HCC and adjacent liver specimens were subjected to tissue microarray. The association of 14-3-3ζ and p-Akt levels with the postoperative survival and recurrence in HCC patients was analyzed with univariate and multivariate methods...
February 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29438854/thrombosis-of-the-spleno-mesentiric-portal-axis-following-laparoscopic-sleeve-gastrectomy-a-rare-case-report
#6
Saleh Alshreadah, Rasees Alotaibi, Abdulaziz Aldabaeab, Ibrahim Alhafid
INTRODUCTION: Mesenteric, splenic and portal veins thrombosis (MSPVT) is uncommon complication after sleeve gastrectomy. CASE REPORT: A 38-year-old female underwent laparoscopic sleeve gastrectomy (LSG) for the treatment of morbid obesity, presented 4 weeks later with epigastric pain. Computed tomography (CT) scan revealed superior mesenteric, splenic and the portal veins thrombosis. CONCLUSION: MSPVT is a rare presentation after laparoscopic sleeve gastrectomy, which requires early diagnosis and management and it should be included in the differential diagnosis for unexplained abdominal symptoms after laparoscopic sleeve gastrectomy...
February 9, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29436101/chemoembolization-related-to-good-survival-for-selected-patients-with-hepatocellular-carcinoma-invading-segmental-portal-vein
#7
Jin Hyoung Kim, Ju Hyun Shim, Hyun-Ki Yoon, Heung-Kyu Ko, Jong Woo Kim, Dong Il Gwon
BACKGROUND AND AIMS: We evaluated survival outcomes and prognostic factors associated with survival after transarterial chemoembolization (TACE) in a large cohort of 331 patients with hepatocellular carcinoma (HCC) with segmental portal vein tumor thrombosis (PVTT). METHODS: From 1997 to 2015, a total of 331 patients were included in this study from among 507 patients who underwent TACE as a first-line treatment for HCC with segmental PVTT. RESULTS: After TACE, the median survival of the whole cohort was 10...
February 13, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29432256/portal-vein-thrombosis-yes-or-no-on-anticoagulation-therapy
#8
Fanny Turon, Virginia Hernández-Gea, Juan Carlos García-Pagán
PURPOSE OF REVIEW: To describe portal vein thrombosis (PVT) in the setting of cirrhosis especially in relation to its potential impact on liver transplantation. In addition, the safety and efficacy of anticoagulation is reviewed. RECENT FINDINGS: PVT in cirrhosis occurs in up to 26% of patients awaiting liver transplantation. Different studies have suggested that PVT impacts negatively post-liver transplantation survival, particularly in first year post-liver transplantation and when PVT is complete involving the porto-mesenteric confluence and not allowing physiological anastomosis...
February 9, 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29429910/natural-history-of-patients-with-non-cirrhotic-portal-hypertension-comparison-with-patients-with-compensated-cirrhosis
#9
Stefania Gioia, Silvia Nardelli, Chiara Pasquale, Ilaria Pentassuglio, Valeria Nicoletti, Francesca Aprile, Manuela Merli, Oliviero Riggio
BACKGROUND: The knowledge of natural history of patients with portal hypertension (PH) not due to cirrhosis is less well known than that of cirrhotic patients. AIM: To describe the clinical presentation and the outcomes of 89 patients with non-cirrhotic PH (25 with non-cirrhotic portal hypertension, INCPH, and 64 with chronic portal vein thrombosis, PVT) in comparison with 77 patients with Child A cirrhosis. METHODS: The patients were submitted to a standardized clinical, laboratory, ultrasonographic and endoscopic follow-up...
January 31, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29429212/-the-sources-of-emboli-in-patients-with-pulmonary-embolism-diagnosed-by-autopsy
#10
H Yang, X M Xu, B M Fang
Objective: To study the sources of emboli in patients with pulmonary embolism diagnosed by autopsy, and therefore to provide help in the diagnosis and treatment of thromboembolism. Methods: We retrospectively analyzed the pathology and clinical data of 43 patients with pulmonary embolism diagnosed by autopsy from 1962 to 2012 in Beijing Hospital. Results: In patients with pulmonary embolism diagnosed by autopsy, 32.6% of the emboli came from deep veins of the lower extremities, 9.3% from the renal vein, 9.3% from the prostate sinus, 7...
February 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29428943/comparison-of-outcome-of-hepatic-arterial-infusion-chemotherapy-combined-with-radiotherapy-and-sorafenib-for-advanced-hepatocellular-carcinoma-patients-with-major-portal-vein-tumor-thrombosis
#11
Kenichiro Kodama, Tomokazu Kawaoka, Hiroshi Aikata, Shinsuke Uchikawa, Yuno Nishida, Yuki Inagaki, Masahiro Hatooka, Kei Morio, Takashi Nakahara, Eisuke Murakami, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Keiichi Masaki, Yoji Honda, Nami Mori, Shintaro Takaki, Keiji Tsuji, Hirotaka Kohno, Hiroshi Kohno, Takashi Moriya, Michihiro Nonaka, Hideyuki Hyogo, Yasuyuki Aisaka, Tomoki Kimura, Yasushi Nagata, Kazuaki Chayama
OBJECTIVE: To compare the outcome of hepatic arterial infusion chemotherapy combined with radiotherapy (HAIC + RT) versus sorafenib monotherapy in patients with advanced hepatocellular carcinoma (HCC) and major portal vein tumor thrombosis (PVTT). METHODS: This retrospective study included 108 HCC patients with PVTT of the main trunk or first branch and Child-Pugh ≤7. Sixty-eight received HAIC + RT and 40 received sorafenib. Patients were then assigned to the HAIC + RT group (n = 36) and the sorafenib group (n = 36) through case-control matching...
February 9, 2018: Oncology
https://www.readbyqxmd.com/read/29423936/population-pharmacokinetics-of-enoxaparin-in-early-stage-of-pediatric-liver-transplantation
#12
Mehdi Oualha, Christophe Chardot, Dominique Debray, Fabrice Lesage, Annie Harroche, Sylvain Renolleau, Jean-Marc Treluyer, Saïk Urien
AIM: Preventing post liver transplantation (LT) hepatic artery and portal vein thrombosis includes enoxaparin administration. Enoxaparin pharmacokinetics (PK) has not been investigated in children following LT. We described an enoxaparin PK model in 22 children the first week following the LT. METHODS: Anti-Xa activity time-courses were analyzed using a nonlinear mixed effects approach with Monolix version 2016R. RESULTS: Anti-Xa activity time-courses were well described by a one-compartment model with first order absorption and elimination...
February 8, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29420366/endoscopic-ultrasound-guided-fine-needle-aspiration-of-portal-vein-thrombosis-in-patients-with-chronic-liver-disease-and-suspicion-of-hepatocellular-carcinoma
#13
Antonio Z Gimeno Garcia, Jose R Aparicio, Angel Barturen, Miguel Moreno, David Nicolas-Perez, Enrique Quintero
BACKGROUND: Differentiation between benign and malignant portal vein thrombosis (PVT) in the setting of a hepatocellular carcinoma (HCC) is of paramount importance. Histological analysis is usually not carried out because of potential severe side effects of the percutaneous approach. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) may be safer and may guide the clinical management of patients with HCC. OBJECTIVE: To describe the feasibility of the EUS-FNA in a series of patients with HCC and PVT...
February 7, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29415937/-portal-vein-thrombosis-associated-with-idiopathic-hypereosinophilic-syndrome
#14
Satoshi Kaito, Sakiko Harada, Masao Tsukada, Akira Kojima, Kanichi Iwama, Kazunari Yamada, Kouichi Kajiwara, Kentaro Morikawa, Keiki Shimizu, Yasuji Kozai, Hideki Koudo
A 35-year-old man who previously underwent splenectomy for hereditary spherocytosis at age 29 visited our hospital complaining of fatigue that had started 7 days ago and right upper abdominal pain. Laboratory data showed increased white blood cell and eosinophil count accompanied by severe transaminitis and clotting abnormalities. Computed tomography scan showed multiple embolisms in the portal vein, superior mesenteric vein, right pulmonary artery, and inferior vena cava. Severe liver damage presumably caused by portal vein thrombosis was also observed...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29410393/intentional-modulation-of-portal-venous-pressure-by-splenectomy-saves-the-patient-with-liver-failure-and-portal-hypertension-after-major-hepatectomy-is-delayed-splenectomy-an-acceptable-therapeutic-option-for-secondary-portal-hypertension
#15
Yuichi Takamatsu, Tomohide Hori, Takafumi Machimoto, Toshiyuki Hata, Yoshio Kadokawa, Tatsuo Ito, Shigeru Kato, Daiki Yasukawa, Yuki Aisu, Yusuke Kimura, Taku Kitano, Tsunehiro Yoshimura
BACKGROUND Major or aggressively-extended hepatectomy (MAEH) may cause secondary portal hypertension (PH), and postoperative liver failure (POLF) and is often fatal. Challenges to prevent secondary PH and subsequent POLF, such as shunt creation and splenic arterial ligation, have been reported. However, these procedures have been performed simultaneously only during the initial MAEH. CASE REPORT A 58-year-old female with chronic hepatitis C developed a solitary hepatic cellular carcinoma with portal tumor thrombosis...
February 7, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29407630/low-molecular-weight-heparin-treatment-for-portal-vein-thrombosis-in-liver-cirrhosis-efficacy-and-the-risk-of-hemorrhagic-complications
#16
Jihyun Kwon, Youngil Koh, Su Jong Yu, Jung-Hwan Yoon
INTRODUCTION: Portal vein thrombosis (PVT) is a well-known complication in patients with liver cirrhosis (LC). The aim of this study is to investigate the outcomes of cirrhotic patients with PVT treated with low-molecular-weight heparin (LMWH). METHOD: Ninety-one LC patients with PVT were treated with dalteparin or enoxaparin for six months. Patients with major bleeding during the last three months, severe thrombocytopenia, or impaired renal function were excluded...
February 1, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29399279/predicting-early-outcomes-of-liver-transplantation-in-young-children-the-early-study
#17
Rashid Alobaidi, Natalie Anton, Dominic Cave, Elham Khodayari Moez, Ari R Joffe
AIM: To determine potentially modifiable predictors of early outcomes after liver transplantation in children of age < 3 years. METHODS: This study was a retrospective chart review including all consecutive children of age less than 3-years-old having had a liver transplant done at the Western Canadian referral center from June 2005 to June 2015. Pre-specified potential predictor variables and primary and secondary outcomes were recorded using standard definitions and a case report form...
January 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/29396900/effects-of-early-antiplatelet-therapy-after-splenectomy-with-gastro-oesophageal-devascularization
#18
Jin-Bao Zhou, Bao-Yang Luo, Chi-Wen Liu, Feng Zhu
BACKGROUND: This study aimed to explore the effects of early antiplatelet therapy (APT) for portal vein thrombosis (PVT) in patients with cirrhotic portal hypertension after splenectomy with gastro-oesophageal devascularization. METHODS: We retrospectively analysed 139 patients who underwent splenectomy with gastro-oesophageal devascularization for portal hypertension due to cirrhosis between April 2010 and December 2016. Based on the post-operative platelet values, we used two different APT regimens: APT was started when platelet counts were increased to 200 × 109 /L or above (group A, n = 64) or 300 × 109 /L or above (group B, n = 75)...
February 3, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29394731/-a-case-of-hepatocellular-carcinoma-with-portal-vein-tumor-thrombosis-treated-successfully-with-multidisciplinary-therapy-including-preoperative-stereotactic-body-radiotherapy-sbrt
#19
Sadaaki Nishimura, Akira Tomokuni, Shogo Kobayashi, Kei Asukai, Hirofumi Akita, Hidenori Takahashi, Yoshitomo Yanagimoto, Yusuke Takahashi, Norikatsu Miyoshi, Keijiro Sugimura, Kazuyoshi Yamamoto, Takeshi Ohmori, Masayuki Ohue, Masahiko Yano, Masato Sakon
A 61-year-old man untreated with hepatitis C virus presented to our hospital.He was diagnosed advanced hepatocellular carcinoma(HCC)with portal vein tumor thrombosis(PVTT).The hazy tumor was located in the left lobe, and the tumor thrombus extended into the left portal vein.The patient received stereotactic body radiotherapy(SBRT, 48 Gy/4 Fr)for PVTT. The extended left lobectomy with thrombectomy was performed 12 days after SBRT.Resected specimen was diagnosed histopathologically as a poorly differentiated HCC, vp1, and no viable tumor cells in the tumor thrombosis...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29390512/venous-thromboembolism-related-to-cytomegalovirus-infection-a-case-report-and-literature-review
#20
Amar H Kelkar, Kavitha S Jacob, Eman B Yousif, John J Farrell
RATIONALE: Herein, we present a case of seemingly unprovoked portal vein thrombosis (PVT) occurring in the context of an acute cytomegalovirus (CMV) infection and prolonged debilitating fatigue. PATIENT CONCERNS: A 46-year-old male airline pilot presented with a 2 week history of abdominal pain, nausea, vomiting, watery diarrhea, and daily recurrent fevers. This was in the context of progressive, debilitating fatigue for 3 months forcing the patient to leave his job...
December 2017: Medicine (Baltimore)
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