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https://www.readbyqxmd.com/read/28339548/enhancement-of-the-antidermatophytic-activity-of-silver-nanoparticles-by-q-switched-nd-yag-laser-and-monoclonal-antibody-conjugation
#1
Salama A Ouf, Abdel-Aleam H Mohamed, Amira A El-Adly
The objective of this research was to investigate the effect of silver nanoparticles (AgNPs), free or conjugated with monoclonal antibody and mediated by Q-switched Nd:YAG laser on five dermatophytes. The laser was applied for 45 s at 532 nm and 0.8 J/cm2. The application of AgNPs combined with laser caused an increase in fungal susceptibility compared to application of AgNPs alone. The MIC50 and MIC100 recorded 3 and 9 μg/ml in the case of E. floccosum (the most susceptible species), 10 and 19 μg/ml for T...
October 7, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28339534/inactivation-of-dermatophyte-infection-by-nonthermal-plasma-on-animal-model
#2
Vladimír Scholtz, Hana Soušková, Michaela Švarcová, Vítezslav Kríha, Helena Živná, Jaroslav Julák
Superficial fungal infections are a major epidemiological issue with increasing prevalence and are a common global problem. This article describes experimental therapy of superficial fungal skin infection using low-temperature plasma. Groups of guinea pigs were artificially infected with Trichophyton mentagrophytes SK 3286 dermatophyte and treated with plasma produced by a DC cometary discharge with an inserted grid. The course of infection was a week shorter and milder in animals treated by plasma than that in nontreated animals, the significant lowering of dermatophytic germs also occurred in the treated group...
October 7, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28330133/bioactive-metabolites-produced-by-streptomyces-cheonanensis-vuk-a-from-coringa-mangrove-sediments-isolation-structure-elucidation-and-bioactivity
#3
Ushakiranmayi Mangamuri, Vijayalakshmi Muvva, Sudhakar Poda, Krishna Naragani, Rajesh Kumar Munaganti, Bhujangarao Chitturi, Venkateswarlu Yenamandra
The strain VUK-A was isolated from a sediment sample of the Coringa mangrove ecosystem was identified as Streptomyces cheonanensis based on morphological, physiological, biochemical and molecular properties. Chemical investigation of the secondary metabolites of the strain Streptomyces cheonanensis VUK-A has led to the segregation of two bioactive compounds, namely 2-Methyl butyl propyl phthalate (1) and Diethyl phthalate (2) using column chromatography. The chemical structure of the active compounds was established on the basis of spectroscopic analysis, including (1)H NMR and (13)C NMR spectroscopies, FTIR and EIMS...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329651/infections-in-children-with-eczema-in-uk-general-practice-a-cohort-study
#4
Sinéad M Langan, Katrina Abuabara, Sarah E Henrickson, Ole Hoffstad, David J Margolis
BackgroundCase reports and cross-sectional studies suggest increased risks of cutaneous and non-cutaneous infections in eczema; this relationship needs to be assessed in large population-based studies with diagnostic confirmation. The objective was to examine associations between eczema and common childhood infections.MethodsIndividuals registered prior to age 18 in the Health Improvement Network, a UK general practice database, from 2003 to 2013 were included in this cohort study. We determined the association between eczema and selected infectious outcomes, including cutaneous (dermatophyte, herpes simplex virus, impetigo, molluscum contagiosum and warts), and non-cutaneous infections (otitis media, streptococcal throat infections, and pneumonia)...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28325159/-a-preschooler-with-a-skin-lesion-on-the-face
#5
C van der Bas-Wolvers, R W A Janssens, R S Rijlaarsdam
A 4-year-old girl presented to the paediatric department with a red squamous spot around her right eye. Based on the clinical presentation and anamnesis, we suspected a zoonotic dermatomycosis obtained via her guinea pigs. PCR of the skin flakes revealed dermatophytes.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28321920/xanthothecium-peruvianum-isolated-from-human-stratum-corneum-a-case-report-characterisation-and-short-review-that-suggest-emendation-of-arachnomyces-peruvianus
#6
REVIEW
Jochen Brasch, Vera Beck-Jendroscheck, Karin Voss, Andrey Yurkov, Alberto Miguel Stchigel, Yvonne Gräser
From stratum corneum samples of a palmar eczema, a fungus was isolated that developed white colonies with a yellowish dark reverse, suggestive of dermatophytes. The isolate produced numerous chlamydospores and sparse aleuroconidia, was resistant to cycloheximide, grew well on human stratum corneum samples and was positive in tests for urease production and hair perforation, but no dermatophyte could be identified. After several weeks, cleistothecia with delicate asci and disc-shaped ascospores were formed, suggesting Arachnomyces spp...
March 20, 2017: Mycoses
https://www.readbyqxmd.com/read/28294418/a-critical-review-of-improvement-rates-for-laser-therapy-used-to-treat-toenail-onychomycosis
#7
REVIEW
A K Gupta, S G Versteeg
BACKGROUND: Onychomycosis is a nail infection that is primary caused by dermatophytes. Alternative treatments are needed as current therapies (oral and topical antifungals) have limited effectiveness. Lasers are currently approved by the FDA to temporarily increase the amount of clear nail in onychomycosis patients. Lasers can theoretically elicit fungicidal effects but in practice produce mixed results. OBJECTIVE: This review compares laser-induced improvement rates to FDA approved indications and traditional onychomycosis treatments...
March 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28281037/pathogenic-dermatophytes-survive-in-nail-lesions-during-oral-terbinafine-treatment-for-tinea-unguium
#8
Tomoyuki Iwanaga, Tsuyoshi Ushigami, Kazushi Anzawa, Takashi Mochizuki
Tinea unguium caused by dermatophyte species are usually treated with oral antimycotic, terbinafine (TBF). To understand the mechanisms of improvement and recalcitrance of tinea unguium by oral TBF treatment, a method of quantifying dermatophyte viability in the nail was developed, and the viability of dermatophytes was analyzed in toenail lesions of 14 patients with KOH-positive tinea unguium treated with oral TBF 125 mg/day for up to 16 weeks. Mycological tests, including KOH examination and fungal culture, and targeted quantitative real-time PCR for internal transcribed spacer (ITS) region, including rRNA, were demonstrated at the initial visit and after 8 and 16 weeks of treatment...
March 9, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28278668/chemical-characterisation-and-biological-activity-of-leaf-essential-oils-obtained-from-pistacia-terebinthus-growing-wild-in-tunisia-and-sardinia-island
#9
Alessandra Piras, Hanen Marzouki, Andrea Maxia, Arianna Marengo, Silvia Porcedda, Danilo Falconieri, Maria José Gonçalves, Carlos Cavaleiro, Ligia Salgueiro
In the present work the chemical compositions, measured by GC and GC-MS, of the essential oils obtained by hydrodistillation from leaves of Pistacia terebinthus collected in Bizerte (Tunisia) and Baunei (Italy) are reported. Both essential oils possessed high content of monoterpene hydrocarbons (86.3% and 90.9%, respectively), being α-pinene (62.4 vs. 35.0)%, camphene (3.0 vs. 2.4)%, β-pinene (12.1 vs. 4.5)%, terpinolene (1.7 vs. 35.2)% and β-phellandrene (3.8 vs. 4.5)% the main components. The Tunisian essential oil exhibited higher antifungal activity than the Italian one...
February 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28278624/assessment-of-safe-bioactive-doses-of-foeniculum-vulgare-mill-essential-oil-from-portugal
#10
C Cabral, M Miranda, M J Gonçalves, C Cavaleiro, M T Cruz, L Salgueiro
This study was designed to evaluate the antifungal activity of Foeniculum vulgare essential oil; concomitantly, the safety of bioactive doses was also unveiled, for the first time, in several mammalian cells. The chemical characterisation was made by GC and GC-MS. Antifungal activity was evaluated against yeasts, dermatophytes and Aspergillus strains and germ tube inhibition assay was evaluated using Candida albicans. Cell viability was assessed by the MTT assay. The main constituents of the oil are E-anetol (47%), α-phellandrene (11%), α-pinene (10...
March 2, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28271525/survey-of-malassezia-sp-and-dermatophytes-in-the-cutaneous-microbiome-of-free-ranging-golden-headed-lion-tamarins-leontopithecus-chrysomelas-kuhl-1820
#11
Juan Ja Neves, Marcelo Francelino, Flavia Gl Silva, Luana Cl Baptista, Marina G Bueno, José L Catão-Dias, Camila Molina, Maria Cm Kierulff, Alcides Pissinatti, Selene DA Coutinho
BACKGROUND: Data about the presence of fungi on the cutaneous surface of wild animals are scarce. The aim of this study was to survey dermatophytes and Malassezia sp in the external ear canal and haircoat of Leontopithecus chrysomelas. METHODS: A total of 928 clinical samples were collected from 232 animals: For Malassezia screening 696 samples were studied, 464 of cerumen and 232 of haircoat; another 232 haircoat samples were studied for dermatophyte analysis. RESULTS: A geophilic dermatophyte, Microsporum cookie, was isolated from one young female...
March 8, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28263845/new-polyurethane-nail-lacquers-for-the-delivery-of-terbinafine-formulation-and-antifungal-activity-evaluation
#12
Barbara S Gregorí Valdes, Ana Paula Serro, Paulo M Gordo, Alexandra Silva, Lídia Gonçalves, Ana Salgado, Joana Marto, Diogo Baltazar, Rui Galhano Dos Santos, João Moura Bordado, Helena Margarida Ribeiro
Onychomycosis is a fungal nail infection. The development of new topical antifungal agents for the treatment of onychomycosis has focused on formulation enhancements that optimize the pharmacological characteristics required for its effective treatment. Polyurethanes (PUs) have never been used in therapeutic nail lacquers. The aim of this work has been the development of new PU based nail lacquers with antifungal activity containing 1.0% (w/w) of terbinafine hydrochloride. The biocompatibility, wettability and the prediction of the free volume in the polymeric matrix were assessed using a human keratinocytes cell line, contact angle and Positron Annihilation Lifetime Spectroscopy (PALS) determinations, respectively...
March 2, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28236353/evaluation-of-growth-conditions-and-dna-extraction-techniques-used-in-the-molecular-analysis-of-dermatophytes
#13
Sebastian Gnat, Aneta Nowakiewicz, Grażyna Ziółkowska, Aleksandra Trościańczyk, Barbara Majer-Dziedzic, Przemysław Zięba
AIMS: Recent molecular methods for diagnosis of superficial mycoses have determined the need for a rapid and easy method of extracting DNA. The aim of study was to determine growth conditions and techniques of DNA extraction for Microsporum canis, Trichophyton mentagrophytes, and T. verrucosum. METHODS AND RESULTS: Samples were prepared of each of the DNA extraction methods (phenol-chloroform, CTAB, and four different kits) for all of the incubation periods (four, seven, and 10 d) of the cultures on the solid and in the liquid medium...
February 25, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28231637/preen-oil-and-bird-fitness-a-critical-review-of-the-evidence
#14
Gregorio Moreno-Rueda
The uropygial gland is a holocrine complex exclusive to birds that produces an oleaginous secretion (preen oil) whose function is still debated. Herein, I examine critically the evidence for the many hypotheses of potential functions of this gland. The main conclusion is that our understanding of this gland is still in its infancy. Even for functions that are considered valid by most researchers, real evidence is scarce. Although it seems clear that preen oil contributes to plumage maintenance, we do not know whether this is due to a role in reducing mechanical abrasion or in reducing feather degradation by keratinophilic organisms...
February 23, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28225975/descriptive-analysis-of-mycological-examination-of-patients-with-onychomycosis-treated-in-private-practice
#15
John Verrinder Veasey, Flávio Nappi, Clarisse Zaitz, Laura Hitomi Muramatu
This is a retrospective study of 160 patients treated in private practice in São Paulo from March 2003 to March 2015. We analyzed 171 results of direct mycological examinations and fungal cultures from nail scrapings. The agreement between direct mycological examination results and fungal culture was satisfactory, consistent with the literature (kappa 0.603). The main agent identified was Trichophyton rubrum (51%). We observed an isolation rate of non-dermatophyte filamentous fungi superior to the literature (34%)...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28220547/identification-and-molecular-epidemiology-of-dermatophyte-isolates-by-repetitive-sequence-pcr-based-dna-fingerprinting-using-the-diversilab-system-in-turkey
#16
A Nedret Koc, Mustafa A Atalay, Melek Inci, Fatma M Sariguzel, Hafize Sav
Dermatophyte species, isolation and identification in clinical samples are still difficult and take a long time. The identification and molecular epidemiology of dermatophytes commonly isolated in a clinical laboratory in Turkey by repetitive sequence-based PCR (rep-PCR) were assessed by comparing the results with those of reference identification. A total of 44 dermatophytes isolated from various clinical specimens of 20 patients with superficial mycoses in Kayseri and 24 patients in Hatay were studied. The identification of dermatophyte isolates was based on the reference identification and rep-PCR using the DiversiLab System (BioMerieux)...
February 21, 2017: Mycoses
https://www.readbyqxmd.com/read/28198097/inibitory-effects-of-linalool-on-fungal-pathogenicity-of-clinical-isolates-of-microsporum-canis-and-microsporum-gypseum
#17
Kaltz V S Silva, Maria I O Lima, Gustavo N Cardoso, Aldeir S Santos, Gezaíldo S Silva, Fillipe O Pereira
In humans worldwide, Microsporum sp. is a frequent agent of dermatophytsosis. When considering the emergence of resistant fungi and the clinical relevance of dermatophytosis, terpene antifungal activity is of great interest. Linalool is a monoterpene alcohol with pharmacological properties. In this study, antifungal in vitro activity of linalool and ketoconazole (as a positive control) were evaluated against clinical isolates of M. canis and M. gypseum. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of each drug were determined by broth microdilution...
February 15, 2017: Mycoses
https://www.readbyqxmd.com/read/28188051/incidence-and-biodiversity-of-yeasts-dermatophytes-and-non-dermatophytes-in-superficial-skin-infections-in-assiut-egypt
#18
A H Moubasher, M A Abdel-Sater, Z Soliman
OBJECTIVE: The aim was to identify the incidence of the causal agents from dermatophytes, non-dermatophytes and yeasts in Assiut Governorate employing, beside the morphological and physiological techniques, the genotypic ones. PATIENTS: Samples from infected nails, skin and hair were taken from 125 patients. MATERIALS AND METHODS: Patients who presented with onychomycosis, tinea capitis, tinea corporis, tinea cruris and tinea pedis during the period from February 2012 to October 2015 were clinically examined and diagnosed by dermatologists and were guided to Assiut University Mycological Centre for direct microscopic examination, culturing and identification...
February 7, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28176804/griseofulvin-impairs-intraerythrocytic-growth-of-plasmodium-falciparum-through-ferrochelatase-inhibition-but-lacks-activity-in-an-experimental-human-infection-study
#19
Clare M Smith, Ante Jerkovic, Thy Thuc Truong, Simon J Foote, James S McCarthy, Brendan J McMorran
Griseofulvin, an orally active antifungal drug used to treat dermatophyte infections, has a secondary effect of inducing cytochrome P450-mediated production of N-methyl protoporphyrin IX (N-MPP). N-MPP is a potent competitive inhibitor of the heme biosynthetic-enzyme ferrochelatase, and inhibits the growth of cultured erythrocyte stage Plasmodium falciparum. Novel drugs against Plasmodium are needed to achieve malaria elimination. Thus, we investigated whether griseofulvin shows anti-plasmodial activity. We observed that the intraerythrocytic growth of P...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28164040/tlr2-mice-display-increased-clearance-of-dermatophyte-trichophyton-mentagrophytes-in-the-setting-of-hyperglycemia
#20
Débora de Fátima Almeida, Thais F de Campos Fraga-Silva, Amanda R Santos, Angela C Finato, Camila M Marchetti, Marjorie de Assis Golim, Vanessa S Lara, Maria S P Arruda, James Venturini
Dermatophytosis is one of the most common human infections affecting both immunocompetent individuals and immunocompromised patients, in whom the disease is more aggressive and can reach deep tissues. Over the last decades, cases of deep dermatophytosis have increased and the dermatophyte-host interplay remains poorly investigated. Pattern recognition molecules, such as Toll-like receptors (TLR), play a crucial role against infectious diseases. However, there has been very little research reported on dermatophytosis...
2017: Frontiers in Cellular and Infection Microbiology
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