keyword
https://read.qxmd.com/read/38525812/flawed-mirec-fluoride-and-intelligence-quotient-publications-a-failed-attempt-to-undermine-community-water-fluoridation
#1
JOURNAL ARTICLE
Juliet R Guichon, Colin Cooper, Andrew Rugg-Gunn, James A Dickinson
OBJECTIVE: To assess the evidence presented in a set of articles that use the Canadian Maternal-Infant Research on Environmental Chemicals (MIREC) study database to claim that community water fluoridation (CWF) is associated with harm to foetal and infant cognitive development. METHODS: Critical appraisal of measurements and processes in the MIREC database, and articles derived therefrom. MIREC's cohort is approximately 2000 pregnant women recruited in 10 centres across Canada, 2008-2011, leading to measuring 512 children aged 3-6 years in six cities...
March 25, 2024: Community Dentistry and Oral Epidemiology
https://read.qxmd.com/read/38464284/fluoride-related-changes-in-the-fetal-cord-blood-proteome-a-pilot-study
#2
Sami T Tuomivaara, Dana E Goin, Susan J Fisher, Steven C Hall, Aras N Mattis, Pamela K Den Besten
Background: Fluoride exposure during pregnancy has been associated with various effects on offspring, including changes in behavior and IQ. To provide clues to possible mechanisms by which fluoride affects human fetal development, we completed proteomic analyses of cord blood serum collected from second-trimester pregnant women residing in Northern California with either high or low fluoride exposure, as identified by maternal serum fluoride concentrations. Objective: To identify changes in cord blood proteins associated with maternal serum fluoride concentration in pregnant women living in Northern California...
March 1, 2024: Research Square
https://read.qxmd.com/read/38460703/a-bayesian-benchmark-concentration-analysis-for-urinary-fluoride-and-intelligence-in-adults-in-guizhou-china
#3
JOURNAL ARTICLE
Tingxu Jin, Tongtong Huang, Tianxue Zhang, Quan Li, Cheng Yan, Qian Wang, Xiufang Chen, Jing Zhou, Yitong Sun, Wenqing Bo, Ziqi Luo, Haodong Li, Yan An
Environmental fluoride exposure has been linked to numerous cases of fluorosis worldwide. Previous studies have indicated that long-term exposure to fluoride can result in intellectual damage among children. However, a comprehensive health risk assessment of fluorosis-induced intellectual damage is still pending. In this research, we utilized the Bayesian Benchmark Dose Analysis System (BBMD) to investigate the dose-response relationship between urinary fluoride (U-F) concentration and Raven scores in adults from Nayong, Guizhou, China...
March 7, 2024: Science of the Total Environment
https://read.qxmd.com/read/38330108/does-fluoride-in-drinking-water-risk-iq-loss
#4
Erik Stokstad
A U.S. federal court is examining a controversial link between fluoride and neurotoxicity.
February 9, 2024: Science
https://read.qxmd.com/read/38318766/systematic-review-of-epidemiological-and-toxicological-evidence-on-health-effects-of-fluoride-in-drinking-water
#5
REVIEW
Mohamed Kadry Taher, Franco Momoli, Jennifer Go, Shintaro Hagiwara, Siva Ramoju, Xuefeng Hu, Natalie Jensen, Rowan Terrell, Alex Hemmerich, Daniel Krewski
INTRODUCTION: Fluoride is a naturally occurring substance that is also added to drinking water, dental hygiene products, and food supplements for preventing dental caries. Concerns have been raised about several other potential health risks of fluoride. OBJECTIVE: To conduct a robust synthesis of evidence regarding human health risks due to exposure to fluoride in drinking water, and to develop a point of departure (POD) for setting a health-based value (HBV) for fluoride in drinking water...
January 2024: Critical Reviews in Toxicology
https://read.qxmd.com/read/38039848/integrative-transcriptome-and-metabolome-analysis-of-fluoride-exposure-induced-developmental-neurotoxicity-in-mouse-brain
#6
JOURNAL ARTICLE
Xinliang Zhu, Shunbin Zhang, Xiaoxiao Liu, Huixia Li, Xinyu Zhu, Ji Zhang, Xiaopeng Wang, Min Zhang
Fluoride could cause developmental neurotoxicity and significantly affect the intelligence quotient (IQ) of children. However, the systematic mechanism of neuronal damage caused by excessive fluoride administration in offspring is largely unknown. Here, we present a comprehensive integrative transcriptome and metabolome analysis to study the mechanism of developmental neurotoxicity caused by chronic fluoride exposure. Comparing the different doses of fluoride treatments in two generations revealed the exclusive signature of metabolism pathways and gene expression profiles...
November 30, 2023: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/37906380/epidemiological-analysis-of-drinking-water-type-fluorosis-areas-and-the-impact-of-fluorosis-on-children-s-health-in-the-past-40%C3%A2-years-in-china
#7
JOURNAL ARTICLE
Feiqing Wang, Yanju Li, Dongxin Tang, Jianing Zhao, Bo Yang, Chike Zhang, Min Su, Zhixu He, Xiaodong Zhu, Dong Ming, Yang Liu
This study analyzed the effect of China's fluorosis prevention and control program, which has been in effect for more than 40 years, and the impact of fluorosis on children's health. Relevant research studies were retrieved from the following online databases from the time of their inception to May 2022: PubMed, ScienceDirect, Embase, Cochrane, China National Knowledge Infrastructure, and Wanfang. The Review Manager 5.3 software was used in statistical analyses. This article included seventy studies: Thirty-eight studies reported the effect of improving water quality and reducing fluoride content, the incidence rate of dental fluorosis in children, and the level of urinary fluoride, and thirty-two studies reported the intelligence quotient (IQ) and health status of children...
October 31, 2023: Environmental Geochemistry and Health
https://read.qxmd.com/read/37798092/dose-dependence-of-prenatal-fluoride-exposure-associations-with-cognitive-performance-at-school-age-in-three-prospective-studies
#8
JOURNAL ARTICLE
Philippe Grandjean, Alessandra Meddis, Flemming Nielsen, Iben H Beck, Niels Bilenberg, Carly V Goodman, Howard Hu, Christine Till, Esben Budtz-Jørgensen
BACKGROUND: Fluoride may be a developmental neurotoxicant at elevated exposures. We merged new data from a prospective Odense Child Cohort (OCC) with results from two previous birth cohort studies from Mexico and Canada to characterize the dose-effect relationship in greater detail. METHODS: The OCC contributed 837 mother-child pairs to the total of >1500. We measured creatinine-adjusted urine-fluoride concentrations in maternal urine samples obtained during late pregnancy...
October 5, 2023: European Journal of Public Health
https://read.qxmd.com/read/37371219/association-of-dental-fluorosis-and-urinary-fluoride-with-intelligence-among-schoolchildren
#9
JOURNAL ARTICLE
Yuh-Yih Lin, Wen-Yu Hsu, Chin-En Yen, Suh-Woan Hu
Fluoride is present naturally in water and has been used worldwide for the prevention of caries. Several studies conducted in high water fluoride or endemic fluorosis areas reported that fluoride adversely affected children's cognitive function, but some studies had negative findings. This study aimed to assess the relationship between urinary fluoride, dental fluorosis, and intelligence among schoolchildren living in communities with non-fluoridated drinking water. This cross-sectional study was conducted on 562 children aged 6-12 years in Taichung, Taiwan...
May 31, 2023: Children
https://read.qxmd.com/read/37236475/fluoride-exposure-during-pregnancy-from-a-community-water-supply-is-associated-with-executive-function-in-preschool-children-a-prospective-ecological-cohort-study
#10
JOURNAL ARTICLE
Deborah Dewey, Gillian England-Mason, Henry Ntanda, Andrea J Deane, Mandakini Jain, Nadia Barnieh, Gerald F Giesbrecht, Nicole Letourneau
BACKGROUND: On May 19, 2011, Calgary, Canada stopped fluoridating its drinking water. This prospective ecological study examined if maternal exposure to fluoride during pregnancy from drinking water that was fluoridated at the recommended level of 0.7 mg/L was associated with children's intelligence and executive function at 3-5 years of age. METHODS: Participants were 616 maternal-child pairs enrolled in the Calgary cohort of the Alberta Pregnancy Outcomes and Nutrition (APrON) study between 2009 and 2012...
May 24, 2023: Science of the Total Environment
https://read.qxmd.com/read/37231938/differential-unmet-needs-and-experience-of-restorative-dental-care-in-trajectories-of-dental-caries-experience-a-birth-cohort-study
#11
JOURNAL ARTICLE
Begoña Ruiz, Jonathan M Broadbent, W Murray Thomson, Sandhya Ramrakha, Chuen Lin Hong, Richie Poulton
Dental caries is a chronic and cumulative disease but little has been reported on the continuity of the disease and its treatment through life. Group-based multi-trajectory modelling was used to identify developmental trajectories of untreated carious tooth surfaces (DS), restored tooth surfaces (FS), and teeth extracted due to caries (MT) from ages 9 to 45 years in a New Zealand longitudinal birth cohort, the Dunedin Multidisciplinary Health and Development Study (n=975). Associations between early life risk factors and trajectory group membership were examined by specifying the probability of group membership according to a multinomial logit model...
May 22, 2023: Caries Research
https://read.qxmd.com/read/37211866/-18-f-sodium-fluoride-positron-emission-tomography-quantitation-of-bone-metastases-in-african-american-and-non-african-american-men-with-metastatic-prostate-cancer
#12
JOURNAL ARTICLE
Julian Hazelton, Seongho Kim, Julie L Boerner, Izabela Podgorski, Timothy Perk, Frank Cackowski, Hussein D Aoun, Elisabeth I Heath
BACKGROUND: Bone is the most common site of metastases in men with prostate cancer. The objective of this study was to explore potential racial differences in the distribution of tumor metastases in the axial and appendicular skeleton. METHODS: We conducted a retrospective review of patients with metastatic prostate cancer to the bone as detected by 18 F-sodium fluoride positron emission tomography/computed tomography (18 F-NaF PET/CT) scans. In addition to describing patients' demographics and clinical characteristics, the metastatic bone lesions, and healthy bone regions were detected and quantified volumetrically using a quantitative imaging platform (TRAQinform IQ, AIQ Solutions)...
May 21, 2023: Prostate
https://read.qxmd.com/read/37149958/a-case-study-of-neurodevelopmental-risks-from-combined-exposures-to-lead-methyl-mercury-inorganic-arsenic-polychlorinated-biphenyls-polybrominated-diphenyl-ethers-and-fluoride
#13
JOURNAL ARTICLE
Corinne Sprong, Jan Dirk Te Biesebeek, Mousumi Chatterjee, Gerrit Wolterink, Annick van den Brand, Urska Blaznik, Despo Christodoulou, Amélie Crépet, Bodil Hamborg Jensen, Darja Sokolić, Elke Rauscher-Gabernig, Jiri Ruprich, Andreas Kortenkamp, Jacob van Klaveren
We performed a mixture risk assessment (MRA) case study of dietary exposure to the food contaminants lead, methylmercury, inorganic arsenic (iAs), fluoride, non-dioxin-like polychlorinated biphenyls (NDL-PCBs) and polybrominated diphenyl ethers (PBDEs), all substances associated with declines in cognitive abilities measured as IQ loss. Most of these chemicals are frequently measured in human biomonitoring studies. A component-based, personalised modified reference point index (mRPI) approach, in which we expressed the exposures and potencies of our chosen substances as lead equivalent values, was applied to perform a MRA for dietary exposures...
May 5, 2023: International Journal of Hygiene and Environmental Health
https://read.qxmd.com/read/37120936/association-between-low-fluoride-exposure-and-children-s-intelligence-a-meta-analysis-relevant-to-community-water-fluoridation
#14
JOURNAL ARTICLE
Jayanth V Kumar, Mark E Moss, Honghu Liu, Susan Fisher-Owens
OBJECTIVES: Previous meta-analyses have mainly focused on studies conducted in endemic fluorosis areas with relatively high fluoride concentrations. These are impoverished rural communities in China, India, and Iran, and the findings cannot be generalised to developed countries. Therefore, we investigated the association between fluoride concentrations relevant to community water fluoridation and children's cognition measured with IQ scores by synthesising effect sizes reported in observational studies...
April 28, 2023: Public Health
https://read.qxmd.com/read/36796438/a-scoping-review-of-iodine-and-fluoride-in-pregnancy-in-relation-to-maternal-thyroid-function-and-offspring-neurodevelopment
#15
REVIEW
Adrianne K Griebel-Thompson, Scott Sands, Lynn Chollet-Hinton, Danielle Christifano, Debra K Sullivan, Holly Hull, Susan E Carlson
Iodine (I), an essential nutrient, is important for thyroid function and therefore growth and development. Fluoride (F), also an essential nutrient, strengthens bones and teeth, and prevents childhood dental caries. Both severe and mild-to-moderate I deficiency and high F exposure during development are associated to decreased intelligence quotient with recent reports associating high levels of F exposure during pregnancy and infancy to low intelligence quotient. Both F and I are halogens, and it has been suggested that F may interfere with the role of I in thyroid function...
March 2023: Advances in Nutrition
https://read.qxmd.com/read/36764861/fluoride-exposure-and-hypothyroidism-in-a-canadian-pregnancy-cohort
#16
JOURNAL ARTICLE
Meaghan Hall, Bruce Lanphear, Jonathan Chevrier, Rick Hornung, Rivka Green, Carly Goodman, Pierre Ayotte, Esperanza Angeles Martinez-Mier, R Thomas Zoeller, Christine Till
BACKGROUND: While fluoride can have thyroid-disrupting effects, associations between low-level fluoride exposure and thyroid conditions remain unclear, especially during pregnancy when insufficient thyroid hormones can adversely impact offspring development. OBJECTIVES: We evaluated associations between fluoride exposure and hypothyroidism in a Canadian pregnancy cohort. METHODS: We measured fluoride concentrations in drinking water and three dilution-corrected urine samples and estimated fluoride intake based on self-reported beverage consumption...
December 27, 2022: Science of the Total Environment
https://read.qxmd.com/read/36639015/fluoride-exposure-and-cognitive-neurodevelopment-systematic-review-and-dose-response-meta-analysis
#17
REVIEW
Federica Veneri, Marco Vinceti, Luigi Generali, Maria Edvige Giannone, Elena Mazzoleni, Linda S Birnbaum, Ugo Consolo, Tommaso Filippini
Many uncertainties still surround the possible harmful effect of fluoride exposure on cognitive neurodevelopment in children. The aim of this systematic review and meta-analysis was to characterize this relation through a dose-response approach, by comparing the intelligence quotient (IQ) scores in the highest versus the lowest fluoride exposure category with a random-effects model, within a one-stage dose-response meta-analysis based on a cubic spline random-effects model. Out of 1996 potentially relevant literature records, 33 studies were eligible for this review, 30 of which were also suitable for meta-analysis...
March 15, 2023: Environmental Research
https://read.qxmd.com/read/36397910/assessment-of-fluoride-content-in-water-and-its-impact-on-the-intelligence-quotient-of-school-children-aged-12-13-years
#18
JOURNAL ARTICLE
Diljot Kaur, Kanwalpreet Kaur, Ashish Sharma, Hemant Goyal, Akshay Pahuja, Dinesh Solanki
BACKGROUND: The preliminary study was undertaken with the aim to assess the effect of fluoride content in water on the Intelligence Quotient (IQ) of school children aged 12-13 years residing in areas that differ with respect to fluoride levels. MATERIALS AND METHODS: The IQ was measured using Raven's Colored Progressive Matrices in 90 children, who were life-long residents in three villages (30 children each) of similar population size but differing in the level of fluoride in drinking water...
October 2022: Curēus
https://read.qxmd.com/read/35838408/do-methylenetetrahydrofolate-dehydrogenase-cyclohydrolase-and-formyltetrahydrofolate-synthetase-1-polymorphisms-modify-changes-in-intelligence-of-school-age-children-in-areas-of-endemic-fluorosis
#19
JOURNAL ARTICLE
Zichen Feng, Ning An, Fangfang Yu, Jun Ma, Na Li, Yuhui Du, Meng Guo, Kaihong Xu, Xiangbo Hou, Zhiyuan Li, Guoyu Zhou, Yue Ba
BACKGROUND: Excessive exposure to fluoride can reduce intelligence. Methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 (MTHFD1) polymorphisms have important roles in neurodevelopment. However, the association of MTHFD1 polymorphisms with children's intelligence changes in endemic fluorosis areas has been rarely explored. METHODS: A cross-sectional study was conducted in four randomly selected primary schools in Tongxu County, Henan Province, from April to May in 2017...
July 18, 2022: Chinese Medical Journal
https://read.qxmd.com/read/35799913/a-systems-approach-to-remediating-human-exposure-to-arsenic-and-fluoride-from-overexploited-aquifers
#20
JOURNAL ARTICLE
P S K Knappett, P Farias, G R Miller, J Hoogesteger, Y Li, I Mendoza-Sanchez, R T Woodward, H Hernandez, I Loza-Aguirre, S Datta, Y Huang, G Carrillo, T Roh, D Terrell
In semiarid agricultural regions, aquifers have watered widespread economic development. Falling water tables, however, drive up energy costs and can make the water toxic for human consumption. The study area is located in central Mexico, where arsenic and fluoride are widely present at toxic concentrations in well water. We simulated the holistic outcomes from three pumping scenarios over 100 years (2020-2120); (S1) pumping rates increase at a similar rate to the past 40 years, (S2) remain constant, or (S3) decrease...
July 2022: GeoHealth
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