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https://www.readbyqxmd.com/read/28437891/the-therapeutic-effect-of-nano-encapsulated-and-nano-emulsion-forms-of-carvacrol-on-experimental-liver-fibrosis
#1
Jihan Hussein, Mona El-Banna, Khaled F Mahmoud, Safaa Morsy, Yasmin Abdel Latif, Dalia Medhat, Eman Refaat, Abdel Razik Farrag, Sherien M El-Daly
OBJECTIVE: The present study aimed to compare the therapeutic efficiency of nano-encapsulated and nano-emulsion carvacrol administration on liver injury in thioacetamide (TAA) treated rats. METHODS: To fulfill our target, we used sixty male albino rats classified into six groups as follow: control, nano-encapsulated carvacrol, nano-emulsion carvacrol, thioacetamide, treated nano-encapsulated carvacrol and treated nano-emulsion carvacrol groups. Blood samples were collected from all groups and the separated serum was used for analysis of the following biochemical parameters; aspartate aminotransferase (AST), alanine aminotransferase (ALT), S100 B protein, alpha fetoprotein (AFP) and caspase-3...
April 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28437890/does-propolis-have-any-effect-on-non-alcoholic-fatty-liver-disease
#2
Kemal Kismet, Cigdem Ozcan, Serdar Kuru, Omur Gencay Celemli, Pinar Celepli, Mehmet Senes, Tuncay Guclu, Kadriye Sorkun, Sema Hucumenoglu, Tanju Besler
The aim of this study was to evaluate the therapeutic effect of propolis on non-alcoholic fatty liver disease (NAFLD) in rats. The rats were randomly divided into 3 groups of 10 as the NAFLD, NAFLD+100 and NAFLD+200 groups. The rats were fed with a fatty diet (25g/kg/day) to provoke NAFLD. Then after the formation of fatty liver, a standard diet (SD) (25g/kg/day) was given to the NAFLD group and the other two groups were fed with SD and 100mg/kg (NAFLD+100 Group) or 200mg/kg propolis (NAFLD+200 Group) for two weeks...
April 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28437889/safety-of-sucrose-esters-from-physalis-peruviana-l-in-a-28-day-repeated-dose-study-in-mice
#3
Yanet C Ocampo, Daneiva C Caro, David E Rivera, Luis A Franco
Although extracts and consumed foods from Physalis species contain sucrose esters from their glandular trichomes, there is no experimental data available on their toxicological effects. As peruvioses A and B isolated from Physalis peruviana L. calyces have proved to be effective anti-inflammatory and immunomodulatory compounds, this work aimed to investigate their sub-acute toxicity study and genotoxicity. For this, CD-1(ICR) mice were treated intraperitoneally with peruvioses at doses of 2.5, 5, and 10mg/kg/day for 28 consecutive days, to simulate therapeutic and over-therapeutic dosage levels...
April 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28437888/protective-effects-of-tranilast-on-experimental-colitis-in-rats
#4
Yoshiki Seto, Kouki Kato, Ryota Tsukada, Hiroki Suzuki, Yuuki Kaneko, Yoshiki Kojo, Hideyuki Sato, Satomi Onoue
The present study aimed to verify the efficacy of tranilast (TL) for treating inflammatory bowel disease (IBD) with the use of an experimental colitis model. The experimental colitis model was prepared by intrarectal instillation of 2,4,6-trinitrobenzenesulfonic acid (TNBS; 40mg/kg) dissolved in water containing 25% ethanol. The pharmacological effects of TL after repeated oral administration were evaluated by biomarker and histological analyses, and the pharmacokinetic behavior of TL was also examined after single oral administration...
April 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28437886/activation-of-imidazoline-i1-receptor-by-moxonidine-regulates-the-progression-of-liver-fibrosis-in-the-nrf2-dependent-pathway
#5
Wenfeng Zhang, Xuanfei Li, Yanmin Liu, Hao Chen, Jianping Gong
Imidazoline I1 receptor (I1R) has been recognized as a promising target in the treatment of many diseases, but little is known about its function in liver fibrogenesis. This study aimed to investigate the effect of I1R activation on the development and progression of liver fibrosis. The results showed that I1R expression was decreased in the livers of both patients and mice with liver fibrosis, and in TGF-β-treated hepatic stellate cells (HSCs). Activation of I1R by moxonidine (MOX) significantly inhibited the progression of liver fibrosis in carbon tetrachloride-induced mice and attenuated the activation of HSCs and kupffer cells...
April 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28437839/semicarbazide-sensitive-amine-oxidase-vascular-adhesion-protein-1-inhibition-reduces-lipopolysaccharide-induced-neuroinflammation
#6
Serena Becchi, Alberto Buson, Jonathan Foot, Wolfgang Jarolimek, Bernard W Balleine
BACKGROUND AND PURPOSE: Neuroinflammation is initiated by a variety of stimuli including infections, sepsis, neurodegenerative diseases or traumatic brain injury and if not adequately controlled can lead to various degrees of neuronal damage and behavioural impairment. A critical event in the initial steps of inflammation is neutrophil extravasation. Semicarbazide sensitive amine oxidase (SSAO, also known as vascular adhesion protein 1 or VAP-1) regulates neutrophil adhesion and extravasation...
April 24, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28437805/anti-inflammatory-antipyretic-and-antinociceptive-effects-of-a-cressa-cretica-aqueous-extract
#7
Heba Mohammed Ibrahim Abdallah, Abdelsamed Ibrahim Elshamy, Abd El-Nasser Gaber El Gendy, Ahmed Mohamed Abd El-Gawad, Elsayed Abouelfotowh Omer, Marinella De Leo, Luisa Pistelli
Cressa cretica is a widely grown halophytic plant traditionally used for the treatment of different ailments. Previous investigations reported its biological activity on a wide spectrum of diseases. In this study, in vivo antinociceptive, anti-inflammatory, and antipyretic activities of C. cretica aqueous extract whole plant were evaluated. In addition, the total polyphenol content, the total flavonoid content, and the chemical characterization of the extract were performed. C. cretica showed writhing inhibition in acetic acid-induced peripheral nociception of 43 and 48 % at doses of 50 and 100 mg/kg, respectively...
April 24, 2017: Planta Medica
https://www.readbyqxmd.com/read/28437745/comparative-study-of-the-effects-of-gadolinium-chloride-and-gadolinium-based-magnetic-resonance-imaging-contrast-agent-on-freshwater-mussel-dreissena-plymorpha
#8
Houda Hanana, Patrice Turcotte, Chantale André, Christian Gagnon, François Gagné
Gadolinium (Gd), a metal of the lanthanide series used in various industrial and medical purposes is released into the aquatic environment. However, there are few aquatic toxicological studies addressing environmental effects of Gd which remains unknown in aquatic animals. Therefore, this study aimed to compare the effects of GdCl3 and a gadolinium-based MRI contrast agent (Omniscan), in zebra mussels after 28 days through a multibiomarker approach. Data revealed that after GdCl3 exposure, the mRNA level of metallothionein (MT) was modulated, those of cytochrome c oxidase (CO1) and superoxide dismutase (SOD) were increased, while gene expressions of catalase (CAT) and glutathione-S-transferase (GST) were downregulated...
April 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28437743/eco-pharmacovigilance-of-non-steroidal-anti-inflammatory-drugs-necessity-and-opportunities
#9
REVIEW
Bing-Shu He, Jun Wang, Juan Liu, Xia-Min Hu
Eco-pharmacovigilance (EPV) is a practical and powerful approach to minimize the potential risks posed by pharmaceutical residues in environment. However, it is impracticable to practise rigorous and unitary EPV process for all the existing and new pharmaceuticals. Here, we focused on non-steroidal anti-inflammatory drugs (NSAIDs), and discussed the necessity and potential opportunities of practising EPV of NSAIDs. We found that the consumption of NSAIDs is huge and ubiquitous across the globe. NSAIDs were worldwidely reported as one of the most dominant and frequently detected groups in environmental matrices including wastewater, surface water, suspended solids, sediments, groundwater, even drinking water...
April 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28437655/peripheral-artery-disease-redox-signaling-oxidative-stress-basic-and-clinical-aspects
#10
REVIEW
Sebastian Steven, Andreas Daiber, Jörn F Dopheide, Thomas Münzel, Christine Espinola-Klein
Reactive oxygen and nitrogen species (ROS and RNS, e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. At higher concentrations, ROS and RNS lead to oxidative stress and oxidative damage of biomolecules (e.g. via formation of peroxynitrite, fenton chemistry). Peripheral artery disease (PAD) is characterized by severe ischemic conditions in the periphery leading to intermittent claudication and critical limb ischemia (end stage)...
April 13, 2017: Redox Biology
https://www.readbyqxmd.com/read/28437591/fluorofenidone-attenuates-il-1%C3%AE-production-by-interacting-with-nlrp3-inflammasome-in-unilateral-ureteral-obstruction
#11
Linfeng Zheng, Jin Zhang, Xiangning Yuan, Juan Tang, Sisi Qiu, Zhangzhe Peng, Qiongjing Yuan, Yanyun Xie, Wenjuan Mei, Yiting Tang, Jie Meng, Gaoyun Hu, Lijian Tao
AIM: We explored whether Fluorofenidone reduced IL-1β production by interacting with NLRP3 inflammasome in unilateral ureteral obstruction (UUO). METHODS: UUO rats were treated with Fluorofenidone (500 mg · kg · d) for 3, 7 days. Morphologic analysis and leukocytes infiltration were assessed in ligated kidneys. Furthermore, plasmids of NLRP3, ASC, pro-Caspase-1, pro-IL-1β were co-transfected into 293 T cells, and then treated with Fluorofenidone (2 mM)...
April 24, 2017: Nephrology
https://www.readbyqxmd.com/read/28437445/knowledge-and-perception-of-cardiovascular-disease-risk-among-patients-with-rheumatoid-arthritis
#12
Sunjoo Boo, Hyunjin Oh, Erika S Froelicher, Chang-Hee Suh
Patients with rheumatoid arthritis are at increased risk for cardiovascular disease. The prerequisites for reducing the risk of cardiovascular disease are adequate levels of knowledge and being aware of the risk. In this study, the levels of knowledge about cardiovascular disease among patients with rheumatoid arthritis and the perception were evaluated in relation to their actual 10-year risk of cardiovascular disease. This cross-sectional study of 200 patients with rheumatoid arthritis was conducted in a university-affiliated hospital in South Korea...
2017: PloS One
https://www.readbyqxmd.com/read/28436750/emap-ii-sensitize-u87mg-and-glioma-stem-like-cells-to-temozolomide-via-induction-of-autophagy-mediated-cell-death-and-g2-m-arrest
#13
Qi Yu, Libo Liu, Ping Wang, Yilong Yao, Yixue Xue, Yunhui Liu
Despite the fact that temozolomide (TMZ) has been widely accepted as the key chemotherapeutic agent to prolong the survival of patients with glioblastoma, failure and recurrence cases can still be observed in clinics. Glioma stem-like cells (GSCs) are thought to be responsible for the drug resistance. In this study, we investigate whether endothelial monocyte-activating polypeptide-II (EMAP-II), a pro-inflammatory cytokine, can enhance TMZ cytotoxicity on U87MG and GSCs or not. As described in prior research, GSCs have been isolated from U87MG and maintained in the serum-free DMEM/F12 medium containing EGF, b-FGF, and B27...
April 24, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28436710/ischemic-ulcer-pain-is-both-nociceptive-and-neuropathic-pain-based-on-a-discriminant-function-analysis-using-the-mcgill-pain-questionnaire
#14
Takamichi Kogure, Masahiko Sumitani, Hiroaki Abe, Jun Hozumi, Reo Inoue, Kazuhito Mietani, Kazuo Kawahara, Yoshitsugu Yamada
The McGill Pain Questionnaire (MPQ) is composed of 78 words reflecting the mechanisms underlying chronic pain conditions. Ischemic ulcer pain is generally regarded as a nociceptive and inflammatory pain condition. However, it is sometimes refractory to nonsteroidal anti-inflammatory drug (NSAID) and opioid treatment. We categorized ischemic pain into nociceptive/inflammatory pain (NocP) or neuropathic pain (NeP), on the basis of patients' descriptions of their pain using the MPQ. We investigated pain characteristics of 365 patients with NeP and 124 with NocP using the 78 words of the MPQ...
April 24, 2017: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/28436638/-research-progress-on-the-animal-models-and-treatment-strategies-of-diabetic-foot-ulcer
#15
Siqian Gao, Yongmei Shen, Funeng Geng, Yanhua Li, Jianqing Gao
The suitable experimental animal model is important in research of pathogenesis and therapeutic strategies of diabetic foot ulcer, and the murine model is the most commonly used one at present. It can be divided into two types: the animal model simulating pathological conditions and the model simulating clinical symptoms. This article reviews the current research progress on the mechanisms of diabetic ulcer pathogenesis, and relevant treatment strategies, including the inhibition of matrix metalloproteinases (MMPs) expression, promotion of angiogenesis and anti-inflammatory therapy...
January 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28436459/identification-of-pro-inflammatory-cd205-macrophages-in-livers-of-hepatitis-b-virus-transgenic-mice-and-patients-with-chronic-hepatitis-b
#16
Liang Yong, Minmin Li, Yimin Gao, Yanru Deng, Wenbin Liu, Dake Huang, Cuiping Ren, Miao Liu, Jijia Shen, Xin Hou
Hepatic macrophages play a central role in disease pathogenesis during hepatitis B virus (HBV) infection. Our previous study found that CD205(+) macrophages in the liver of hepatitis B surface antigen transgenic (HBs-Tg) mice increased significantly compared with those in wild-type mice, and these increased CD205(+) macrophages were involved in CpG-oligodeoxynucleotide-induced liver injury in HBs-Tg mice. Here, we analysed the phenotype and function of CD205(+) macrophages derived from the liver of HBs-Tg mice and patients with chronic hepatitis B (CHB)...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28436446/opioid-self-administration-is-attenuated-by-early-life-experience-and-gene-therapy-for-anti-inflammatory-il-10-in-the-nucleus-accumbens-of-male-rats
#17
Michael J Lacagnina, Ashley M Kopec, Stewart S Cox, Richa Hanamsagar, Corinne Wells, Susan Slade, Peter M Grace, Linda R Watkins, Edward D Levin, Staci D Bilbo
Early-life conditions can contribute to the propensity for developing neuropsychiatric disease, including substance abuse disorders. However, the long-lasting mechanisms that shape risk or resilience for drug addiction remain unclear. Previous work has shown that a neonatal handling procedure in rats (which promotes enriched maternal care) attenuates morphine conditioning, reduces morphine-induced glial activation, and increases microglial expression of the anti-inflammatory cytokine interleukin-10 (IL-10)...
April 24, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28436303/choline-supplementation-during-pregnancy-protects-against-gestational-lipopolysaccharide-induced-inflammatory-responses
#18
Min Zhang, Xinjia Han, Juejie Bao, Jinying Yang, Shao-Qing Shi, Robert E Garfield, Huishu Liu
OBJECTIVES: To estimate the effects and mechanisms of choline, an essential nutrient and a selective α7 nicotinic acetylcholine receptor (α7nAChR) agonist, on the prevention of symptoms and the effects on the cholinergic anti-inflammatory pathways (CAP) in a lipopolysaccharide (LPS)-induced inflammatory response in a rat model. METHODS: Inflammation was induced by LPS treatment (1.0 μg LPS/kg body weight) on gestational day (GD) 14. Nonpregnant and pregnant Sprague Dawley rats were placed on a normal choline diet (1...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28436274/depletion-of-hdl3-high-density-lipoprotein-and-altered-functionality-of-hdl2-in-blood-from-sickle-cell-patients
#19
Eric Soupene, Sandra K Larkin, Frans A Kuypers
In sickle cell disease (SCD), alterations of cholesterol metabolism is in part related to abnormal levels and activity of plasma proteins such as lecithin cholesterol acyltransferase (LCAT), and apolipoprotein A-I (ApoA-I). In addition, the size distribution of ApoA-I high density lipoproteins (HDL) differs from normal blood. The ratio of the amount of HDL2 particle relative to the smaller higher density pre-β HDL (HDL3) particle was shifted toward HDL2. This lipoprotein imbalance is exacerbated during acute vaso-occlusive episodes (VOE) as the relative levels of HDL3 decrease...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28436117/early-introduction-of-oral-paricalcitol-in-renal-transplant-recipients-an-open-label-randomized-study
#20
Hege Kampen Pihlstrøm, Franscesca Gatti, Clara Hammarström, Ivar Anders Eide, Monika Kasprzycka, Junbai Wang, Guttorm Haraldsen, My Hanna Sofia Svensson, Karsten Midtvedt, Geir Mjøen, Dag Olav Dahle, Anders Hartmann, Hallvard Holdaas
In stable renal transplant recipients with hyperparathyroidism, previous studies have indicated that vitamin D agonist treatment might have anti-proteinuric effects. Animal studies indicate possible anti-fibrotic and anti-inflammatory effects. Early introduction of paricalcitol in de-novo renal transplant recipients might reduce proteinuria and prevent progressive allograft fibrosis. We performed a single-centre, prospective, randomized, open-label trial investigating effects of paricalcitol 2μg/day added to standard care...
April 24, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
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