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https://www.readbyqxmd.com/read/29156575/synthesis-of-oxadiazole-thiadiazole-hybrids-and-their-anticandidal-activity
#1
Serkan Levent, Betül Kaya Çavuşoğlu, Begüm Nurpelin Sağlık, Derya Osmaniye, Ulviye Acar Çevik, Özlem Atlı, Yusuf Özkay, Zafer Asım Kaplancıklı
In the field of infection management, it is a major challenge to discover a potent and safe antifungal agent due to the emergence of resistant strains. Hence, the goal of this paper is to design and synthesize novel oxadiazole-thiadiazole hybrid compounds (6a-6s) and evaluate their antifungal activity. The structures of synthesized compounds were elucidated by various methods including FT-IR, ¹H-NMR, (13)C-NMR and HR-MS spectral data. Compounds were tested against four Candida species by broth microdilution assay...
November 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29156492/bayesian-monotonic-errors-in-variables-models-with-applications-to-pathogen-susceptibility-testing
#2
Glen DePalma, Bruce A Craig
Drug dilution (MIC) and disk diffusion (DIA) are the 2 most common antimicrobial susceptibility assays used by hospitals and clinics to determine an unknown pathogen's susceptibility to various antibiotics. Since only one assay is commonly used, it is important that the 2 assays give similar results. Calibration of the DIA assay to the MIC assay is typically done using the error-rate bounded method, which selects DIA breakpoints that minimize the observed discrepancies between the 2 assays. In 2000, Craig proposed a model-based approach that specifically models the measurement error and rounding processes of each assay, the underlying pathogen distribution, and the true monotonic relationship between the 2 assays...
November 20, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29156457/discovery-of-novel-thiazol-2-amines-and-their-analogues-as-bioactive-molecules-design-synthesis-docking-and-biological-evaluation
#3
Anil Kumar Verma, Abha Bishnoi, Shaheen Fatma, Huda Parveen, Vineeta Singh
A simple and highly efficient procedure for the synthesis of novel thiazol-2-amines, via Mannich reaction with secondary amines, is described. The newly synthesized derivatives 8(a-e) and 9(a-e) were characterized by (1)H NMR, (13)C NMR, IR, Mass spectroscopy and elemental analysis. All the derivatives were evaluated for their in-vitro anti-microbial activity against a panel of pathogenic strains of bacteria and fungi. The SAR showed that the secondary amines had a significant impact on the in-vitro antimicrobial activity of this class of agents...
November 20, 2017: Drug Research
https://www.readbyqxmd.com/read/29155275/antibacterial-compounds-from-the-australian-native-plant-eremophila-glabra
#4
Azizah A Algreiby, Katherine A Hammer, Zoey Durmic, Phil Vercoe, Gavin R Flematti
Recent reports of Eremophila glabra (R.Br.) Ostenf. (Scrophulariaceae) displaying antibacterial activity has led us to investigate the bioactive secondary metabolites responsible for this activity. Bioassay-directed fractionation of solvent extracts prepared from the leaves of E. glabra led to the isolation of seven serrulatane diterpenes, three flavonoids and the caffeoyl ester disaccharide verbascoside. Among these, four serrulatanes, namely 18-acetoxy-8, 20-dihydroxyserrulat-14-en-19-oic acid (14), 18,20-diacetoxy-8-hydroxyserrulat-14-en-19-oic acid (16), 8,18,20-triacetoxyserrulat-14-en-19-oic acid (17) and 18-acetoxy-8-hydroxyserrulat-14-en-19-oic acid (18) are described for the first time, while 8,20-diacetoxyserrulat-14-en-19-oic acid (3), 8,18,20-trihydroxyserrulat-14-en-19-oic acid (5) and 20-acetoxy-8-hydroxyserrulat-14-en-19-oic acid (19) were previously reported...
November 15, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29155212/effect-of-isoquercitrin-on-membrane-dynamics-and-apoptosis-like-death-in-escherichia-coli
#5
JiEun Yun, Eun-Rhan Woo, Dong Gun Lee
Minimum inhibitory concentration (MIC) is defined as the lowest concentration of a compound that completely inhibits microbial growth. Antibacterial mechanisms of compounds have been investigated at their sub-MICs as well as at their MIC. In this study, the effects of sub-MIC and MIC of isoquercitrin on Escherichia coli were investigated. The antibacterial effect of isoquercitrin was tested using the microdilution method. Sub-MICs of isoquercitrin induced the production of reactive oxygen species and depletion of glutathione...
November 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29154899/combining-diagnostic-methods-for-antimicrobial-susceptibility-testing-a-comparative-approach
#6
Sylvia Natalie Kłodzińska, Petra Alexandra Priemel, Thomas Rades, Hanne Mørck Nielsen
BACKGROUND: The minimum inhibitory concentration (MIC) is a measure of antimicrobial susceptibility testing (AST) of a given antibiotic, but provides insufficient information when bacterial killing is crucial, e.g. when treating immunocompromised patients. In these cases, the minimum bactericidal concentration (MBC) is a more reliable measure of antibiotic activity. Here, we aim to demonstrate and recommend combinations of methods for MIC and MBC measurements. We also aim to emphasize the importance of uniform protocols for these procedures including the time point for reading MIC results, which the authors suggest to be 20h...
November 14, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29154480/in-vitro-activity-and-time-kill-curve-analysis-of-sitafloxacin-against-a-global-panel-of-antimicrobial-resistant-and-multidrug-resistant-neisseria-gonorrhoeae-isolates
#7
Agnez Jönsson, Sunniva Foerster, Daniel Golparian, Ryoichi Hamasuna, Susanne Jacobsson, Magnus Lindberg, Jörgen Skov Jensen, Makoto Ohnishi, Magnus Unemo
Treatment of gonorrhoea is a challenge worldwide because of emergence of resistance in N. gonorrhoeae to all therapeutic antimicrobials available and novel antimicrobials are imperative. The newer-generation fluoroquinolone sitafloxacin, mostly used for respiratory tract infections in Japan, can have a high in vitro activity against gonococci. However, only a limited number of recent antimicrobial-resistant isolates from Japan have been examined. We investigated the sitafloxacin activity against a global gonococcal panel (250 isolates cultured in 1991-2013), including multidrug-resistant geographically, temporally and genetically diverse isolates, and performed time-kill curve analysis for sitafloxacin...
November 20, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29153784/an-empirical-comparison-of-isolate-based-and-sample-based-definitions-of-antimicrobial-resistance-and-their-effect-on-estimates-of-prevalence
#8
R W Humphry, J Evans, C Webster, S C Tongue, G T Innocent, G J Gunn
Antimicrobial resistance is primarily a problem in human medicine but there are unquantified links of transmission in both directions between animal and human populations. Quantitative assessment of the costs and benefits of reduced antimicrobial usage in livestock requires robust quantification of transmission of resistance between animals, the environment and the human population. This in turn requires appropriate measurement of resistance. To tackle this we selected two different methods for determining whether a sample is resistant - one based on screening a sample, the other on testing individual isolates...
November 10, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29153524/minimum-inhibitory-concentrations-of-frequently-used-antibiotics-against-escherichia-coli-and-trueperella-pyogenes-isolated-from-uteri-of-postpartum-dairy-cows
#9
A Pohl, A Lübke-Becker, W Heuwieser
The objective of this study was to determine minimum inhibitory concentrations (MIC) of frequently used antimicrobials for Escherichia coli and Trueperella pyogenes isolated from postpartum bovine uteri of cows with acute puerperal metritis (APM, n = 67), cows suspected to have APM (n = 37), and healthy cows (n = 37) and to evaluate possible differences in MIC according to clinical signs. Cows with APM had reddish-brown, fetid vaginal discharge and rectal temperature (RT) ≥39.5°C within 21 d in milk; cows suspected to have APM had either reddish-brown, fetid vaginal discharge or RT ≥39...
November 15, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29153069/-emerging-pathogen-candida-kefyr-kluvyeromyces-marxianus
#10
Tuğba Çuhadar, Ayşe Kalkancı
In the central microbiology laboratory of Gazi University Hospital Candida kefyr was isolated from different clinical samples as 5.3% in 2016 and in 2017 this rate increased to 9.3% which was nearly two-fold and this has drawn our attention. The aim of this study was to evaluate the special characteristics, antifungal susceptibility and virulence properties of C.keyfr species. Germ tube, corn meal-tween 80 agar morphology and carbohydrate assimilation profiles on ID32C yeast identification system were used for the diagnosis of Candida species...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29153061/-defining-of-gene-mutations-and-minimal-inhibitory-concentrations-in-isoniazid-resistant-mycobacterium-tuberculosis-isolates
#11
Esra Yıldırım, Meltem Uzun
Tuberculosis is a very important disease all over the world despite the advanced diagnostic and treatment regimens. Resistant tuberculosis, which has increased in recent years in particular, is a global problem and prevents the fight against tuberculosis. For this reason, it is important to determine the etiologic agent early and its sensitivity against antituberculosis drugs. Resistance profiles of the isolates and the gene mutations causing resistance are determined for epidemiological purposes and mutation regions of the isolates are being investigated on the basis of countries...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29152950/investigation-of-class-d-beta-lactamases-causing-carbapenem-resistance-in-clinical-acinetobacter-baumannii-isolates
#12
Iskandar Davandeh, Bayrı Eraç, Sabire Şöhret Aydemir
Background/aim: Acinetobacter baumannii is an important causative agent of nosocomial infections, and carbapenems have been frequently used in the treatment of these infections. This study was designed to investigate the prevalence of primary carbapenem hydrolyzing oxacillinase (CHO) types in clinical A. bumannii strains. Materials and methods: Minimum inhibitory concentration (MIC) values of 76 imipenem nonsusceptible A. baumannii strains, isolated from a tertiary care hospital, were determined by microdilution method...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29152837/effect-of-nanoliposomes-containing-zataria-multiflora-boiss-essential-oil-on-gene-expression-of-shiga-toxin-2-in-escherichia-coli-o157-h7
#13
Seyed Amin Khatibi, Ali Misaghi, Mir-Hassan Moosavy, Afshin Akhondzadeh Basti, Samira Mohamadian, Ali Khanjari
AIMS: Enterohaemorrhagic Escherichia coli (EHEC) serotype O157:H7 as a major human pathogen is responsible for food borne outbreaks, bloody diarrhea, hemorrhagic colitis and hemolytic uremic syndrome (HUS) and even death. In this study, the antibacterial activity of the Zataria multiflora essential oil (ZMEO) and nanoliposome-encapsulated ZMEO was evaluated on the pathogenicity of Escherichia coli O157:H7. METHODS AND RESULTS: The minimum inhibitory concentrations (MIC) of essential oil (EO) were determined against the bacterium before and after encapsulation into nanoliposome...
November 20, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29152635/profiling-polyphenol-composition-by-hplc-dad-esi-msn-and-the-antibacterial-activity-of-infusion-preparations-obtained-from-four-medicinal-plants
#14
Borhane E C Ziani, Lillian Barros, Ali Z Boumehira, Khaldoun Bachari, Sandrina A Heleno, Maria Jose Alves, Isabel C F R Ferreira
The infusions of Thymus pallescens Noë, Saccocalyx satureioides Coss. et Dur., Ptychotis verticillata Briq. and Limoniastrum guyonianum Boiss. have been used as medicinal remedies for many diseases in Algerian folk medicine. These species have also been well documented as rich sources of phytochemicals, such as phenolic compounds with wide diversified chemical structures, which exhibit far-ranging biological activities. Thus, the phenolic compound profile of the aqueous extracts, obtained by infusing, of the mentioned species was obtained by HPLC-DAD-ESI/MS, and their antibacterial activity was evaluated against clinical isolates...
November 20, 2017: Food & Function
https://www.readbyqxmd.com/read/29151994/antimicrobial-activity-of-cultivable-endophytic-fungi-associated-with-hancornia-speciosa-gomes-bark
#15
Mardonny Bruno de Oliveira Chagas, Irailton Prazeres Dos Santos, Luis Claudio Nascimento da Silva, Maria Tereza Dos Santos Correia, Janete Magali de Araújo, Marilene da Silva Cavalcanti, Vera Lucia de Menezes Lima
Introduction: In this study, we evaluated the antimicrobial potential of cultivable endophytic fungi associated with Hancornia speciosa Gomes stem bark. Methods and Materials: Plant samples were collected in rainy (July 2010) and dry (January 2011) seasons. In total, 116 endophytic fungi strains were isolated from 90 fragments (64.4% frequency of colonization). Higher fungi frequency was observed in the rainy season (84.4%). The strains were grouped into 14 species; the most frequent were Phoma cava (13...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/29151992/aerococcus-urinae-and-aerococcus-sanguinicola-susceptibility-testing-of-120-isolates-to-six-antimicrobial-agents-using-disk-diffusion-eucast-etest-and-broth-microdilution-techniques
#16
Derya Carkaci, Xiaohui C Nielsen, Kurt Fuursted, Robert Skov, Ole Skovgaard, Emilio P Trallero, Reto Lienhard, Jenny Åhman, Erika Matuschek, Gunnar Kahlmeter, Jens J Christensen
Background: Aerococcus urinae and Aerococcus sanguinicola are relatively newcomers and emerging organisms in clinical and microbiological practice. Both species have worldwide been associated with urinary tract infections. More rarely cases of bacteremia/septicemia and infective endocarditis have been reported. Treatment options are therefore important. Just recently, European recommendations on susceptibility testing and interpretive criteria have been released. Objective: In this investigation 120 A...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/29151652/antimicrobial-efficacy-of-synthetic-pyranochromenones-and-coumarinyloxy-acetamides
#17
Abhishek K Singh, Suchita Prasad, Bipul Kumar, Shiv Kumar, Amitesh Anand, Shashank S Kamble, Sunil K Sharma, Hemant K Gautam
Four (1, 2, 4 and 6) synthetic quaternary ammonium derivatives of pyranochromenones and (coumarinyloxy)acetamides were synthesized and investigated for their antimicrobial efficacy on MRSA (Methicillin-resistant Staphylococcus aureus), and multi-drug resistant Pseudomonas aeruginosa, Salmonella enteritidis and Mycobacterium tuberculosis H37Rv strain. One of the four compounds screened i.e. N,N,N-triethyl-10-((4,8,8-trimethyl-2-oxo-2,6,7,8-tetrahydropyrano[3,2-g]chromen-10-yl)oxy)decan-1-aminium bromide (1), demonstrated significant activity against S...
December 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29150592/the-influence-of-genetic-stability-on-aspergillus-fumigatus-virulence-and-azole-resistance
#18
Thaila Fernanda Dos Reis, Lilian Pereira Silva, Patrícia Alves de Castro, Pollyne Borborema Almeida de Lima, Rafaela Andrade do Carmo, Marjorie Mendes Marini, José Franco da Silveira, Beatriz Henriques Ferreira, Fernando Rodrigues, Iran Malavazi, Gustavo H Goldman
Genetic stability is extremely important for the survival of every living organism and a very complex set of genes have evolved to cope with DNA repair upon DNA damage. Here, we investigated the Aspergillus fumigatus AtmA (Ataxia-telangiectasia mutated) and AtrA kinases and how they impact virulence and the evolution of azole resistance. We demonstrated that A. fumigatus atmA and atrA null mutants are haploid and have a discrete chromosomal polymorphism. The ΔatmA and ΔatrA strains are sensitive to several DNA damaging agents but surprisingly both strains were more resistant than the wild-type strain to paraquat, menadione, and hydrogen peroxide...
November 17, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29150378/enhanced-antibacterial-effects-of-green-synthesized-zno-nps-using-aristolochia-indica-against-multi-drug-resistant-bacterial-pathogens-from-diabetic-foot-ulcer
#19
Katherin Steffy, G Shanthi, Anson S Maroky, S Selvakumar
BACKGROUND: Increased incidence of Multi-drug resistance in microorganisms has become the greatest challenge in the treatment of Diabetic Foot Ulcer (DFU) and urges the need of a new antimicrobial agent. In this study, we determined the bactericidal effects of ZnO nanoparticles (ZnO NPs) green synthesized from Aristolochia indica against Multi-drug Resistant Organisms (MDROs) isolated from pus samples of DFU patients attending in a tertiary care hospital in South India. METHODS: ZnO NPs were characterized by UV-vis-DRS spectroscopy, Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM) and for its zeta potential value...
November 14, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29150050/cytogenetic-changes-in-the-bhopal-population-exposed-to-methyl-isocyanate-mic-in-1984-then-and-30-years-later
#20
Bani Bandana Ganguly, Shouvik Mandal
Following the 1984 Bhopal methyl isocyanate (MIC) gas disaster, genetic alterations were sporadically reported on small cohorts. However, the outcome of the multi-center cytogenetic screening conducted at that time remains unknown and no follow-up studies on the long-term effects of MIC exposure have been published. The present work examines genetic changes in the exposed population,with the aim of identifying any long-term effects of MIC. G-Banded metaphases were studied in lymphocytes of 130 individuals. Chromosomal aberrations (CA) were broadly grouped as abnormal cells (Abc), aberrations (Abn), and aberration/abnormal cell (Abn/Abc)...
December 2017: Mutation Research
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