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https://www.readbyqxmd.com/read/28938539/dissemination-of-macrolides-fusidic-acid-and-mupirocin-resistance-among-staphylococcus-aureus-clinical-isolates
#1
Xingmei Liu, Shanshan Deng, Jinwei Huang, Yaling Huang, Yu Zhang, Qin Yan, Yanhong Wang, Yanyue Li, Chengfu Sun, Xu Jia
As an increasingly common cause of skin infections worldwide, the prevalence of antibiotic-resistant Staphylococcus aureus (S. aureus) across China has not been well documented. This literature aims to study the resistance profile to commonly used antibiotics, including macrolides, fusidic acid (FA) and mupirocin, and its relationship to the genetic typing in 34 S. aureus strains, including 6 methicillin-resistant S. aureus (MRSA), isolated from a Chinese hospital. The MIC results showed 27 (79.4%), 1 (2.9%) and 6 (17...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937657/synthesis-of-2-4-diaminopyrimidine-core-based-derivatives-and-biological-evaluation-of-their-anti-tubercular-activities
#2
Yifan Ouyang, Hao Yang, Peng Zhang, Yu Wang, Sargit Kaur, Xuanli Zhu, Zhe Wang, Yutong Sun, Wei Hong, Yun Fong Ngeow, Hao Wang
Tuberculosis (TB) is a chronic, potentially fatal disease caused by Mycobacterium tuberculosis (Mtb). The dihyrofolate reductase in Mtb (mt-DHFR) is believed to be an important drug target in anti-TB drug development. This enzyme contains a glycerol (GOL) binding site, which is assumed to be a useful site to improve the selectivity towards human dihyrofolate reductase (h-DHFR). There have been previous attempts to design drugs targeting the GOL binding site, but the designed compounds contain a hydrophilic group, which may prevent the compounds from crossing the cell wall of Mtb to function at the whole cell level...
September 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28937623/antifungal-activity-of-thapsia-villosa-essential-oil-against-candida-cryptococcus-malassezia-aspergillus-and-dermatophyte-species
#3
Eugénia Pinto, Maria-José Gonçalves, Carlos Cavaleiro, Lígia Salgueiro
The composition of the essential oil (EO) of Thapsia villosa (Apiaceae), isolated by hydrodistillation from the plant's aerial parts, was analysed by GC and GC-MS. Antifungal activity of the EO and its main components, limonene (57.5%) and methyleugenol (35.9%), were evaluated against clinically relevant yeasts (Candida spp., Cryptococcus neoformans and Malassezia furfur) and moulds (Aspergillus spp. and dermatophytes). Minimum inhibitory concentrations (MICs) were measured according to the broth macrodilution protocols by Clinical and Laboratory Standards Institute (CLSI)...
September 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28936957/-pk-pd-of-vancomycin-in-patients-with-severe-acute-pancreatitis-combined-with-augmented-renal-clearance
#4
Juan He, Enqiang Mao, Feng Jing, Huiting Jiang, Wenyun Xu, Wanhua Yang, Erzhen Chen
OBJECTIVE: To evaluate the serum trough concentration and the pharmacokinetics/pharmacodynamics (PK/PD) of vancomycin in patients with severe acute pancreatitis (SAP), and analyze the effect of vancomycin continuous infusion for optimizing the characteristics of its PK/PD. METHODS: The inhospital patients with SAP received vancomycin treatment and admitted to emergency intensive care unit (EICU) of Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine from January 2011 to December 2016 were enrolled...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28934980/in-vitro-antibiotic-susceptibility-and-biofilm-production-of-staphylococcus-aureus-isolates-recovered-from-bovine-intramammary-infections-that-persisted-or-not-following-extended-therapies-with-cephapirin-pirlimycin-or-ceftiofur
#5
Céline Ster, Valérie Lebeau, Julia Leclerc, Alexandre Fugère, Koui A Veh, Jean-Philippe Roy, François Malouin
Staphylococcus aureus intramammary infections (IMIs) have low cure rates using standard antibiotic treatment and increasing the duration of treatment usually improves therapeutic success. Chronic IMIs are thought to be caused by bacteria presenting a specific virulence phenotype that includes the capacity to produce greater amounts of biofilm. In this study, antibiotic susceptibility and biofilm production by S. aureus isolates recovered from IMIs that were cured or not following an extended therapy with cephapirin, pirlimycin or ceftiofur for 5, 8 and 8 days, respectively, were compared...
September 21, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28934346/antibacterial-effects-of-carbon-dots-in-combination-with-other-antimicrobial-reagents
#6
Xiuli Dong, Mohamad Al Awak, Nicholas Tomlinson, Yongan Tang, Ya-Ping Sun, Liju Yang
This study was designed to investigate the antimicrobial effects of CDots in combination with other antimicrobial reagents, including H2O2, Na2CO3, and AcOH (acetic acid). CDots were synthesized and passivated with 2,2'-(ethylenedioxy)bis(ethylamine) (EDA). The minimal inhibitory concentration (MIC) of CDots was 64 μg/mL on both Gram negative bacteria E.coli cells and Gram positive bacteria Bacillus subtilis cells. When CDots were combined with H2O2, antibacterial synergistic effects were observed based on the fractional inhibitory concentration (FIC) index, and further confirmed by an isobologram analysis and viable cell number counting methods...
2017: PloS One
https://www.readbyqxmd.com/read/28932951/structure-elucidation-and-in-silico-docking-studies-of-a-novel-furopyrimidine-antibiotics-synthesized-by-endolithic-bacterium-actinomadura-sp-al2
#7
Kaushik Bhattacharjee, Shakti Kumar, Narasinga Rao Palepu, Pradeep Kumar Patra, Kollipara Mohan Rao, Santa Ram Joshi
On screening of endolithic actinobacteria from a granite rock sample of Meghalaya for antibacterial compound, a novel antibacterial compound CCp1 was isolated from the fermentation broth of Actinomadura sp. AL2. On purification of the compound based on chromatographic techniques followed by characterization with FT-IR, UV-visible, (1)H NMR, (13)C NMR and mass spectrometry, the molecular formula of the compound was generated as C20H17N3O2, a furopyrimidine derivative. In vitro antibacterial activity of the compound was evaluated against both Gram positive and negative bacteria by agar well diffusion assay...
September 20, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28932713/antibiotic-resistance-patterns-of-methicillin-resistant-staphylococcus-aureus-mrsa-isolated-from-livestock-and-associated-farmers-in-anuradhapura-sri-lanka
#8
Jayaweera Arachchige Asela Sampath Jayaweera, Wikum Widuranga Kumbukgolla
INTRODUCTION: The animal husbandry comes to play an important role according to new economic reforms of the rural economy in South Asia including Sri Lanka, and the rural farming community has a poor knowledge about hygienic issues of animal husbandry, which can lead to spread of pathogenic bacterial strains from animals to humans. Our study was conducted to evaluate methicillin susceptible Staphylococcus aureus (MRSA) colonization and its antimicrobial resistance pattern among livestock (n=188) and related farmers (n=94) in Anuradhapura District, Sri Lanka...
September 2017: Germs
https://www.readbyqxmd.com/read/28932712/multidrug-and-co-resistance-patterns-of-non-fermenting-gram-negative-bacilli-involved-in-ventilator-associated-pneumonia-carrying-class-1-integron-in-the-north-of-iran
#9
Masoumeh Bagheri-Nesami, Mohammad Sadegh Rezai, Fatemeh Ahangarkani, Alireza Rafiei, Attieh Nikkhah, Gohar Eslami, Kheironesa Shafahi, Azin Hajalibeig, Rezvan Khajavi
INTRODUCTION: Ventilator-associated pneumonia (VAP) due to non-fermenting Gram-negative bacilli (NFGNB), especially Pseudomonas aeruginosa and Acinetobacter spp., is one of the main hospital-acquired infections leading to mortality and morbidity, especially in intensive care units (ICUs). This study seeks to determine the multidrug and co-resistance (MDR) patterns of NFGNB that are agents of VAP, and assess the presence of class 1 integron in these bacteria. METHODS: This cross-sectional study involved VAP patients admitted in the ICUs of 18 hospitals in the Mazandaran province, located in the North of Iran...
September 2017: Germs
https://www.readbyqxmd.com/read/28932329/molecular-characterization-of-klebsiella-pneumoniae-clinical-isolates-with-elevated-resistance-to-carbapenems
#10
Rasha Barwa, Mona Shaaban
BACKGROUND: Emergence of carbapenems-resistant K. pneumoniae represents a serious challenge for antimicrobial therapy. OBJECTIVE: The aim of this research is to determine different mechanisms mediating the emergence of K. pneumoniae isolates with high-level carbapenem resistance. METHOD: A total of 80 K. pneumoniae isolates were purified from sputum and urine specimens. The minimum inhibitory concentrations (MICs) of imipenem and meropenem were determined by broth microdilution method...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/28932210/antibacterial-activity-of-endophytic-actinomycetes-isolated-from-the-medicinal-plant-vochysia-divergens-pantanal-brazil
#11
Francielly M W R Gos, Daiani C Savi, Khaled A Shaaban, Jon S Thorson, Rodrigo Aluizio, Yvelise M Possiede, Jürgen Rohr, Chirlei Glienke
Endophytic actinomycetes from medicinal plants produce a wide diversity of secondary metabolites (SM). However, to date, the knowledge about endophytes from Brazil remains scarce. Thus, we analyzed the antimicrobial potential of 10 actinomycetes isolated from the medicinal plant Vochysia divergens located in the Pantanal sul-mato-grossense, an unexplored wetland in Brazil. Strains were classified as belonging to the Aeromicrobium, Actinomadura, Microbacterium, Microbispora, Micrococcus, Sphaerisporangium, Streptomyces, and Williamsia genera, through morphological and 16S rRNA phylogenetic analyzes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28931947/cytochalasan-and-tyrosine-derived-alkaloids-from-the-marine-sediment-derived-fungus-westerdykella-dispersa-and-their-bioactivities
#12
Dan Xu, Minghe Luo, Fenglou Liu, Dong Wang, Xuejiao Pang, Ting Zhao, Lulin Xu, Xia Wu, Mingyu Xia, Xiaolong Yang
Six new cytochalasans, designated as 18-oxo-19,20-dihydrophomacin C (1), 18-oxo-19-methoxy-19,20- dihydrophomacin C (2), 18-oxo-19-hydroxyl-19,20-dihydrophomacin C (3), 19,20-dihydrophomacin C (4), 19-methoxy-19,20-dihydrophomacin C (5), 19-hydroxyl-19,20-dihydrophomacin C (6), and one new tyrosine-derived alkaloid named as gymnastatin Z (8), together with two known compounds, phomacin B (7) and triticone D (9), were isolated from a solid-substrate fermentation culture of Westerdykella dispersa which was derived from marine sediments...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931320/chemical-and-biomolecular-analyses-to-discriminate-three-taxa-of-pistacia-genus-from-sardinia-island-italy-and-their-antifungal-activity
#13
Arianna Marengo, Alessandra Piras, Danilo Falconieri, Silvia Porcedda, Pierluigi Caboni, Pierluigi Cortis, Caterina Foddis, Claudia Loi, Maria José Gonçalves, Lígia Salgueiro, Andrea Maxia
This work reports the results and the comparison concerning the chemical and biomolecular analyses and the antifungal activity of three wild Pistacia species (Anacardiaceae) from Sardinia. Volatile oils from leaves and twigs of Pistacia x saportae, Pistacia lentiscus and Pistacia terebinthus were characterised using GC-FID and GC-MS techniques and tested against some fungal strains. Two DNA nuclear regions (ITS and 5S-rRNA-NTS) were amplified through PCR technique and sequenced. The three **Pistacia have similar chemical profile, although there are some important quantitative differences...
September 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28931202/different-sized-incisions-for-phacoemulsification-in-age-related-cataract
#14
REVIEW
Chongfei Jin, Xinyi Chen, Andrew Law, Yunhee Kang, Xue Wang, Wen Xu, Ke Yao
BACKGROUND: Age-related cataract is the principal cause of blindness and visual impairment in the world. Phacoemulsification is the main surgical procedure used to treat cataract. The comparative effectiveness and safety of different-sized incisions for phacoemulsification has not been determined. OBJECTIVES: The aim of this systematic review was to assess the effectiveness and safety of smaller versus larger incisions for phacoemulsification in age-related cataract...
September 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28930254/synthesis-antimicrobial-and-antioxidant-activities-of-chalcogen-containing-nitrone-derivatives-from-r-citronellal
#15
Mariana C Ferraz, Renata A Mano, Daniela H Oliveira, Darla S V Maia, Wladimir P Silva, Lucielli Savegnago, Eder J Lenardão, Raquel G Jacob
Background: The main constituents of Cymbopogonnardus (L) Rendle and C. citratus (DC) Stapfessential oils are (R)-citronellal and citral, respectively. Organochalcogen compounds can boost the biological activities of natural products. Methods: Several chalcogen-containing nitrones derived from (R)-citronellal and citral were prepared and evaluated for their antimicrobial and antioxidant activities. The antimicrobial activity was evaluated by the disc diffusion test and the antioxidant properties were evaluated in vitro by DPPH (1,1-diphenyl-2-picryl-hydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid), and FRAP (ferric ion reducing antioxidant power) assays...
June 10, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930247/chemical-composition-and-in-vitro-cytotoxic-and-antimicrobial-activities-of-the-essential-oil-from-leaves-of-zanthoxylum-monogynum-st-hill-rutaceae
#16
Fernanda B da Silva, Nara O Dos Santos, Renata C Pascon, Marcelo A Vallim, Carlos R Figueiredo, Roberto C Campos Martins, Patricia Sartorelli
Background: The Zanthoxylum monogynum species belongs to the family Rutaceae and is found in Southeast, Midwest, and Northeast Brazil. For this genus several biological activities have been described. Methods: The essential oil (EO) was obtained from the leaves of Zanthoxylum monogynum by hydro-distillation and was analyzed by gas chromatograph and gas chromatograph/mass spectrometry (GC and GC/MS). Also the EO of Z. monogynum was evaluated for in vitro cytotoxic activity against six tumor cell lines and for antimicrobial activity, performing disk diffusion and MIC assays with yeast and bacterial strains...
May 19, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930242/essential-oils-from-leaves-of-medicinal-plants-of-brazilian-flora-chemical-composition-and-activity-against-candida-species
#17
Maria da Conceição Mendes Ferreira da Costa, Alexandre Gomes da Silva, Ana Paula Sant'Anna da Silva, Vera Lúcia de Menezes Lima, Patrícia Cristina Bezerra-Silva, Suyana Karolyne Lino da Rocha, Daniela Maria do Amaral Ferraz Navarro, Maria Tereza Dos Santos Correia, Thiago Henrique Napoleão, Márcia Vanusa da Silva, Patrícia Maria Guedes Paiva
Background: The biotechnological potential of medicinal plants from Brazilian Caatinga and the Atlantic Forest has not been extensively studied. Thus, screening programs are important in prospecting for compounds for developing new drugs. The purpose of this study was to determine the chemical composition and to evaluate the anti-Candida activity of essential oils from leaves of Hymenaea courbaril var. courbaril, Myroxylon peruiferum, and Vismia guianensis. Methods: The oils were extracted through hydrodistillation and their chemical compositions were analyzed by gas chromatography coupled with mass spectrometry...
May 3, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930241/chemical-composition-antimicrobial-and-antioxidant-activities-of-essential-oils-from-two-avicennia-schaueriana-stapf-leechm-ex-moldenke-acanthaceae-populations
#18
Kamilla N Machado, Telma M Kaneko, Maria Cláudia M Young, Cynthia Murakami, Inês Cordeiro, Paulo Roberto H Moreno
BACKGROUND: Avicennia schaueriana Stapf & Leechm. ex Moldenke (Acanthaceae) is a native species from the Brazilian mangroves presenting ecological and economic significance. This study compared the composition and the biological activities from the essential oils obtained from two A. schaueriana populations collected at Jureia-Itatins and Ilha do Cardoso. METHODS: Essential oils were obtained by conventional means, and their compositions were analyzed by GC-MS...
May 1, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930240/anti-bacterial-activity-of-phenolic-compounds-against-streptococcus-pyogenes
#19
Sabrina Macé, Lisbeth Truelstrup Hansen, H P Vasantha Rupasinghe
BACKGROUND: Worldwide, Streptococcus pyogenes is the leading cause of bacterial pharyngitis. To reduce the use of antibiotics, antimicrobial phytochemical-containing remedies, which have long been in use in traditional medicine, may provide new approaches for management of streptococcal pharyngitis. The objective of this study was to assess the inhibitory activities of 25 natural phenolic compounds against three strains of S. pyogenes. METHODS: After an initial screening, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the nine most effective phenolic compounds were determined...
May 1, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930232/antimicrobial-antioxidant-and-cytotoxic-activities-of-ocimum-forskolei-and-teucrium-yemense-lamiaceae-essential-oils
#20
Nasser A Awadh Ali, Bhuwan K Chhetri, Noura S Dosoky, Khola Shari, Ahmed J A Al-Fahad, Ludger Wessjohann, William N Setzer
Background:Ocimum forskolei and Teucrium yemense (Lamiaceae) are used in traditional medicine in Yemen. Methods: The chemical composition, antimicrobial, antioxidant and cytotoxic activities of the essential oils isolated from the leaves of Ocimum forskolei Benth. (EOOF) and two different populations of Teucrium yemense Deflers., one collected from Dhamar province (EOTY-d), and another collected from Taiz (EOTY-t) were investigated. The antimicrobial activities of the oils were evaluated against several microorganisms with the disc diffusion test or the broth microdilution test...
April 1, 2017: Medicines (Basel, Switzerland)
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