keyword
https://read.qxmd.com/read/38495508/dhea-down-regulates-mitochondrial-dynamics-and-promotes-apoptosis-of-lung-adenocarcinoma-cells-through-fastkd2
#21
JOURNAL ARTICLE
Yan-Fei Zhang, Liu-Liu Yuan, Zong-Can Wang, Wen-Bin Zhuang, Wen-Jia Zhang, Hai-Tao Liu, Ming Li, Li-Hong Fan
Background: DHEA is a steroid hormone produced by the gonads, adrenal cortex, brain, and gastrointestinal tract. While the anti-obesity, anti-atherosclerosis, anti-cancer, and memory-enhancing effects of DHEA have been substantiated through cell experiments, animal studies, and human trials, the precise mechanisms underlying these effects remain unclear. Altered mitochondrial dynamics can lead to mitochondrial dysfunction, which is closely related to many human diseases, especially cancer and aging. This study was to investigate whether DHEA inhibits lung adenocarcinoma through the mitochondrial pathway and its molecular mechanism...
2024: Journal of Cancer
https://read.qxmd.com/read/38494933/paeoniflorin-alleviates-anxiety-and-visceral-hypersensitivity-via-hpa-axis-and-bdnf-trkb-plc%C3%AE-1-pathway-in-maternal-separation-induced-ibs-like-rats
#22
JOURNAL ARTICLE
Ruifeng Liang, Wenjing Ge, Xianmei Song, Huisen Wang, Weifeng Cui, Xuexia Zhang, Zheng Wei, Gengsheng Li
BACKGROUND: Irritable Bowel Syndrome (IBS) is a prevalent gastrointestinal disorder that significantly diminishes the quality of life for affected individuals. The pathophysiology of IBS remains poorly understood, and available therapeutic options for IBS are limited. The crucial roles of brain-gut interaction, which is mediated by the Hypothalamic-Pituitary-Adrenocortical (HPA) axis and the autonomic nervous system in IBS, have attracted increasing attention. OBJECTIVE: The objective of this study was to examine the impact of paeoniflorin (PF) on anxiety and visceral hypersensitivity in maternal separation-induced IBS-like rats...
March 15, 2024: Current Molecular Pharmacology
https://read.qxmd.com/read/38490854/long-term-outcomes-and-patterns-of-relapse-following-high-dose-elective-salvage-radiotherapy-and-hormone-therapy-in-oligorecurrent-pelvic-nodes-in-prostate-cancer-oligopelvis-getug-p07
#23
JOURNAL ARTICLE
Loig Vaugier, Cyrille Morvan, David Pasquier, Xavier Buthaud, Nicolas Magné, Veronique Beckendorf, Paul Sargos, Gilles Crehange, Pascal Pommier, Genevieve Loos, Ali Hasbini, Igor Latorzeff, Marlon Silva, Julie Paul, Audrey Blanc-Lapierre, Stéphane Supiot
Androgen deprivation therapy (ADT) is a mainstay of treatment for metastatic prostate cancer, while additional salvage radiotherapy may offer prolonged remission for patients with regional node relapses. We report 5-yr outcomes from OLIGOPELVIS (GETUG-P07), an open-label phase 2 trial assessing long-term outcomes and patterns of relapse after 6-mo ADT and elective nodal radiotherapy (ENRT) in men with pelvic nodal oligorecurrence (<6 lesions) of prostate cancer. Progression was defined as two consecutive prostate-specific antigen (PSA) levels above the level at inclusion and/or clinical progression according to Response Evaluation Criteria in Solid Tumors v1...
March 14, 2024: European Urology
https://read.qxmd.com/read/38490517/novel-mechanisms-involved-in-leptin-sensitization-in-obesity
#24
REVIEW
Veronica Pena-Leon, Raquel Perez-Lois, Maria Villalon, Eva Prida, Diego Muñoz-Moreno, Johan Fernø, Mar Quiñones, Omar Al-Massadi, Luisa M Seoane
Leptin is a hormone that is secreted by adipocytes in proportion to adipose tissue size, and that informs the brain about the energy status of the body. Leptin acts through its receptor LepRb, expressed mainly in the hypothalamus, and induces a negative energy balance by potent inhibition of feeding and activation of energy expenditure. These actions have led to huge expectations for the development of therapeutic targets for metabolic complications based on leptin-derived compounds. However, the majority of patients with obesity presents elevated leptin production, suggesting that in this setting leptin is ineffective in the regulation of energy balance...
March 13, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38489380/photo-neuro-immuno-endocrinology-how-the-ultraviolet-radiation-regulates-the-body-brain-and-immune-system
#25
JOURNAL ARTICLE
Radomir M Slominski, Jake Y Chen, Chander Raman, Andrzej T Slominski
Ultraviolet radiation (UVR) is primarily recognized for its detrimental effects such as cancerogenesis, skin aging, eye damage, and autoimmune disorders. With exception of ultraviolet B (UVB) requirement in the production of vitamin D3, the positive role of UVR in modulation of homeostasis is underappreciated. Skin exposure to UVR triggers local responses secondary to the induction of chemical, hormonal, immune, and neural signals that are defined by the chromophores and extent of UVR penetration into skin compartments...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38489132/biochemical-characteristics-and-clinical-manifestation-of-normocalcemic-primary-hyperparathyroidism
#26
JOURNAL ARTICLE
Inna Yankova, Lora Lilova, Daniela Petrova, Inna Dimitrova, Mariya Stoynova, Alexander Shinkov, Roussanka Kovatcheva
BACKGROUND: Normocalcemic primary hyperparathyroidism (nPHPT) is a condition characterized by persistently high levels of parathyroid hormone (PTH) and normal serum calcium levels in the absence of other causes for secondary hyperparathyroidism. The aim of the present study was to assess the clinical presentation and the biochemical characteristics in patients with nPHPT and to compare them with those in patients with hypercalcemic PHPT (hPHPT). MATERIALS AND METHODS: The study included 316 patients (277 women and 39 men, average age 58...
March 15, 2024: Endocrine
https://read.qxmd.com/read/38488556/unraveling-the-gut-brain-axis-the-impact-of-steroid-hormones-and-nutrition-on-parkinson-s-disease
#27
JOURNAL ARTICLE
Paula Maria Neufeld, Ralf A Nettersheim, Veronika Matschke, Matthias Vorgerd, Sarah Stahlke, Carsten Theiss
This comprehensive review explores the intricate relationship between nutrition, the gut microbiome, steroid hormones, and Parkinson's disease within the context of the gut-brain axis. The gut-brain axis plays a pivotal role in neurodegenerative diseases like Parkinson's disease, encompassing diverse components such as the gut microbiota, immune system, metabolism, and neural pathways. The gut microbiome, profoundly influenced by dietary factors, emerges as a key player. Nutrition during the first 1000 days of life shapes the gut microbiota composition, influencing immune responses and impacting both child development and adult health...
October 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38486712/gut-derived-peptide-hormone-analogues-and-potential-treatment-of-bone-disorders-in-obesity-and-diabetes-mellitus
#28
REVIEW
Asif Ali, Peter R Flatt, Nigel Irwin
Obesity and diabetes mellitus are prevalent metabolic disorders that have a detrimental impact on overall health. In this regard, there is now a clear link between these metabolic disorders and compromised bone health. Interestingly, both obesity and diabetes lead to elevated risk of bone fracture which is independent of effects on bone mineral density (BMD). In this regard, gastrointestinal (GIT)-derived peptide hormones and their related long-acting analogues, some of which are already clinically approved for diabetes and/or obesity, also seem to possess positive effects on bone remodelling and microarchitecture to reduce bone fracture risk...
2024: Clinical Medicine Insights. Endocrinology and Diabetes
https://read.qxmd.com/read/38484565/fermented-bamboo-powder-activates-gut-odorant-receptors-and-promotes-intestinal-health-and-growth-performance-of-dwarf-yellow-feathered-broiler-chickens
#29
JOURNAL ARTICLE
Rahmani Mohammad Malyar, Quanwei Wei, Linsong Hou, Shoura Hytham Elsaid, Yuanchao Zhang, Sayed Attaul Haq Banuree, Saifullah, Weisheng Zhou, Fangxiong Shi
The present study investigated the effects of fermented bamboo powder (FPB) on gut odorant receptors (OR), intestinal health, and growth performance of dwarf yellow-feathered broiler chickens. Six hundred (600) healthy 1-day-old chicks were randomly assigned into 2 groups, with 10 replicates consisting of 30 chicks each. The control group was fed a basal diet. In contrast, the experimental group was fed the basal diet supplemented with 1.0, 2.0, 4.0, and 6.0 g/kg FBP for 4 different phases, namely phase I (1-22 d), phase II (23-45 d), phase III (46-60 d), and phase IV (61-77 d), respectively...
February 17, 2024: Poultry Science
https://read.qxmd.com/read/38477380/hypofractionated-radiation-therapy-combined-with-androgen-deprivation-therapy-for-high-risk-localized-prostate-cancer
#30
JOURNAL ARTICLE
Tae Hoon Lee, Hongryull Pyo, Gyu Sang Yoo, Seong Soo Jeon, Seong Il Seo, Byong Chang Jeong, Hwang Gyun Jeon, Hyun Hwan Sung, Minyong Kang, Wan Song, Jae Hoon Chung, Bong Kyung Bae, Won Park
INTRODUCTION: This study aimed to analyse the treatment outcomes of moderately hypofractionated radiation therapy (RT) combined with androgen deprivation therapy (ADT) and the prognostic implications of prostate-specific antigen (PSA) kinetics in high-risk localized prostate cancer. METHODS: The medical records of 140 patients who underwent definitive RT (70 Gy in 28 fractions) combined with ADT were retrospectively reviewed. ADT consists of a gonadotropin-releasing hormone agonist and an anti-androgen...
March 13, 2024: Journal of Medical Imaging and Radiation Oncology
https://read.qxmd.com/read/38476126/intragastric-injection-of-botulinum-toxin-in-the-treatment-of-obesity-a-single-center-study
#31
JOURNAL ARTICLE
Hasan Tankut Köseoğlu, Kerem Kenarli, Ahmet Akbay, Çağdaṣ Erdoğan, Alper Macif, Meryem Didem Göktaṣ, Mevlüt Hamamci, Çağdaṣ Kalkan, Firathan Sarialtin, Mahmut Yüksel
BACKGROUND: In recent years, various novel surgical and non-surgical therapeutic options have been developed for treating obesity. Due to its disputed success, intragastric botulinum toxin A (BTX-A) injection is still being debated. OBJECTIVES: We aim to contribute to this controversial issue in the literature by sharing our center's findings regarding intragastric BTX-A injections in the treatment of obesity. DESIGN: Patients with a body mass index (BMI) of greater than 25 kg/m2 and at least one obesity-related complication, or a BMI of greater than 30 kg/m2 without complications, were eligible for the study if they were between the ages of 18 and 65...
2024: Therapeutic advances in gastrointestinal endoscopy
https://read.qxmd.com/read/38474749/metabolic-effects-of-selected-conventional-and-alternative-sweeteners-a-narrative-review
#32
REVIEW
Fabienne Teysseire, Valentine Bordier, Christoph Beglinger, Bettina K Wölnerhanssen, Anne Christin Meyer-Gerspach
Sugar consumption is known to be associated with a whole range of adverse health effects, including overweight status and type II diabetes mellitus. In 2015, the World Health Organization issued a guideline recommending the reduction of sugar intake. In this context, alternative sweeteners have gained interest as sugar substitutes to achieve this goal without loss of the sweet taste. This review aims to provide an overview of the scientific literature and establish a reference tool for selected conventional sweeteners (sucrose, glucose, and fructose) and alternative sweeteners (sucralose, xylitol, erythritol, and D-allulose), specifically focusing on their important metabolic effects...
February 23, 2024: Nutrients
https://read.qxmd.com/read/38467155/recent-advances-in-molecular-pathways-and-therapeutic-implications-for-peptic-ulcer-management-a-comprehensive-review
#33
JOURNAL ARTICLE
Deepak Chandra Joshi, Nirmal Joshi, Ajeet Kumar, Shubhrat Maheshwari
Peptic ulcers, recognized for their erosive impact on the gastrointestinal mucosa, present a considerable challenge in gastroenterology. Epidemiological insights underscore the global prevalence of peptic ulcers, affecting 5-10+% of individuals, with a yearly incidence of 0.3 to 1.9 cases per thousand. Recent decades have witnessed a decline in complications, attributed to improved diagnostics and therapeutic advancements. The review deepens into H. pylori -associated and NSAID-induced ulcers, emphasizing their distinct prevalence in developing and industrialized nations, respectively...
March 11, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38465401/a-modeling-analysis-of-whole-body-potassium-regulation-on-a-high-potassium-diet-proximal-tubule-and-tubuloglomerular-feedback-effects
#34
JOURNAL ARTICLE
Melissa M Stadt, Anita T Layton
Potassium (K+ ) is an essential electrolyte that plays a key role in many physiological process, including mineralcorticoid action, systemic blood-pressure regulation, as well as hormone secretion and action. Indeed, maintaining K+ balance is critical for normal cell function, as too high or too low K+ levels can have serious and potentially deadly health consequences. K+ homeostasis is achieved by an intricate balance between the intracellular and extracellular fluid as well as balance between K+ intake and excretion...
March 11, 2024: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://read.qxmd.com/read/38462026/comparing-massa-medicata-fermentata-before-and-after-charred-in-terms-of-digestive-promoting-effect-via-metabolomics-and-microbiome-analysis
#35
JOURNAL ARTICLE
Siqi Fan, Huangyao Zhu, Wanqiu Liu, Jingwen Ha, Ying Liu, Ma Mi, Qingjia Ren, Lijun Xu, Jie Zhang, Wenyuan Liu, Feng Feng, Jian Xu
ETHNOPHARMACOLOGICAL RELEVANCE: Massa Medicata Fermentata, a fermented Chinese medicine, is produced by the fermentation of six traditional Chinese medicines. Liu Shenqu (LSQ) and charred Liu Shenqu (CLSQ) have been used for strengthening the spleen and enhancing digestion for over a thousand years, and CLSQ is commonly used in clinical practice. However, it is unclear whether there is a difference in the spleen strengthening and digestion effects between LSQ and CLSQ, as well as their mechanisms of action...
March 8, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38460255/endocrine-disrupting-potential-of-total-and-bioaccessible-extracts-of-dust-from-seven-different-types-of-indoor-environment
#36
JOURNAL ARTICLE
Felipe Augusto Pinto-Vidal, Jiří Novák, Simona Rozárka Jílková, Tatsiana Rusina, Branislav Vrana, Lisa Melymuk, Klára Hilscherová
Information on the indoor environment as a source of exposure with potential adverse health effects is mostly limited to a few pollutant groups and indoor types. This study provides a comprehensive toxicological profile of chemical mixtures associated with dust from various types of indoor environments, namely cars, houses, prefabricated apartments, kindergartens, offices, public spaces, and schools. Organic extracts of two different polarities and bioaccessible extracts mimicking the gastrointestinal conditions were prepared from two different particle size fractions of dust...
February 16, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38453938/sex-specific-epigenetics-drive-low-gper-expression-in-gastrointestinal-smooth-muscles-in-type-2-diabetic-mice
#37
JOURNAL ARTICLE
Aliyu Muhammad, Juanita C Hixon, Abdurrahman Pharmacy Yusuf, Jatna I Rivas Zarete, India Johnson, Jamial Miller, Benjamin Adu-Addai, Clayton Yates, Sunila Mahavadi
Type 2 diabetes mellitus (T2D) causes gastroparesis, delayed intestinal transit, and constipation, for unknown reasons. Complications are predominant in women than men (particularly pregnant and postmenopausal women), suggesting a female hormone-mediated mechanism. Low G-protein coupled estrogen receptor (GPER) expression from epigenetic modifications may explain it. We explored sexually differentiated GPER expression and gastrointestinal symptoms related to GPER alterations in wild-type (WT) and T2D mice (db/db)...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38452803/correction-serological-screening-for-celiac-disease-and-gastrointestinal-absorption-disorders-in-patients-with-autoimmune-endocrine-diseases
#38
JOURNAL ARTICLE
Aysen Akkurt Kocaeli, Soner Cander, Özen Öz Gül, Pınar Sisman, Canan Ersoy, Erdınc Erturk
No abstract text is available yet for this article.
November 2023: Hormone and Metabolic Research
https://read.qxmd.com/read/38445918/somatostatin-alleviates-diversion-colitis-after-fecal-stream-bypass-colostomy-surgeries-in-rats
#39
JOURNAL ARTICLE
Yonghao Chen, Xiaoxi Xie, Yaoyu Guo, Yanni Li, Chong Geng, Xiao Li, Chunhui Wang
BACKGROUND: Diversion colitis (DC) is a prevalent complication of colostomy characterized by intestinal inflammation. This study aimed to investigate the therapeutic potential of somatostatin (SST) in managing DC. METHODS: After establishing a rat DC model, SST was administered via Mini Osmotic Pumps 2001W at a pumping rate of 1.0 μL/h. Various techniques, including hematoxylin and eosin staining, periodic acid-Schiff staining, immunofluorescence staining, and electron microscopy were employed to assess the effects of SST...
March 2024: Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38444475/multicomponent-comprehensive-confirms-that-erythroferrone-is-a-molecular-biomarker-of-pan-cancer
#40
JOURNAL ARTICLE
Ying Cai, Yaling Gao, Yinyin Lv, Zhiyuan Chen, Lingfeng Zhong, Junjie Chen, Yanyun Fan
All vertebrates organisms produce erythroferrone, a secretory hormone with structure-related functions during iron homeostasis. However, limited knowledge exists regarding the effect of this hormone on the occurrence and progression of cancer. To systematically and comprehensively identify the diverse implications of Erythroferrone (ERFE) in various malignant tumors, we conducted an in-depth analysis of multiple datasets, including the expression levels of oncogenes and target proteins, biological functions, and molecular characteristics...
March 15, 2024: Heliyon
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