keyword
MENU ▼
Read by QxMD icon Read
search

Adverse Childhood Event

keyword
https://www.readbyqxmd.com/read/29333764/education-is-the-strongest-socioeconomic-predictor-of-smoking-in-pregnancy
#1
Juho Härkönen, Matti Lindberg, Linnea Karlsson, Hasse Karlsson, Noora M Scheinin
AIMS: To investigate socioeconomic disparities in smoking in pregnancy (SIP) by the mother's education, occupational class, and current economic conditions. DESIGN: Cross-sectional analysis with linked survey and register data. SETTING: South-Western Finland. PARTICIPANTS: 2,667 pregnant women (70% of the original sample (N=3,808)) from FinnBrain, a prospective pregnancy cohort study. MEASUREMENTS: The outcome was smoking during the first pregnancy trimester, measured from the Finnish Medical Birth Register...
January 14, 2018: Addiction
https://www.readbyqxmd.com/read/29333125/association-between-slc19a1-gene-polymorphism-and-high-dose-methotrexate-toxicity-in-childhood-acute-lymphoblastic-leukaemia-and-non-hodgkin-malignant-lymphoma-introducing-a-haplotype-based-approach
#2
Barbara Faganel Kotnik, Janez Jazbec, Petra Bohanec Grabar, Cristina Rodriguez-Antona, Vita Dolzan
Background: We investigated the clinical relevance of SLC 19A1 genetic variability for high dose methotrexate (HD-MTX) related toxicities in children and adolescents with acute lymphoblastic leukaemia (ALL) and non Hodgkin malignant lymphoma (NHML). Patients and methods: Eighty-eight children and adolescents with ALL/NHML were investigated for the influence of SLC 19A1 single nucleotide polymorphisms (SNPs) and haplotypes on HD-MTX induced toxicities. Results: Patients with rs2838958 TT genotype had higher probability for mucositis development as compared to carriers of at least one rs2838958 C allele (OR 0...
December 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/29324274/mediators-between-adverse-childhood-experiences-and-suicidality
#3
Minna Rytilä-Manninen, Henna Haravuori, Sari Fröjd, Mauri Marttunen, Nina Lindberg
We investigated whether psychiatric symptomatology, impulsivity, family and social dysfunction, and alcohol use mediate the relationship between adverse childhood experiences (ACEs) and suicidality. The study population comprised 206 adolescent psychiatric inpatients and 203 age- and gender-matched adolescents from the community. ACEs and suicidality were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime version, the Life Events Checklist, and a structured background data collection sheet...
January 8, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29303015/tests-of-the-attachment-and-developmental-dynamic-systems-theory-of-crime-addstoc-toward-a-differential-rdoc-diagnostic-and-treatment-approach
#4
Marc A Lindberg, Dana Zeid
The Attachment and Developmental Dynamic Systems Theory of Crime was tested on 206 male inmates. They completed measures tapping attachments, clinical issues, adverse childhood events, peer crime, and crime addictions. A significant path model was found, going from insecure parental attachments to adverse childhood events, and then on to the behavioral crime addiction and criminal peers scales. Peer crime was also predicted by insecure parent attachments and the crime addiction scale. Finally, the crime addiction, peer crime, and insecure parental attachment scales predicted frequencies of criminal behavior...
January 1, 2018: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29302609/effectiveness-of-the-healthy-lifestyles-programme-help-to-prevent-obesity-in-uk-primary-school-children-a-cluster-randomised-controlled-trial
#5
Jenny Lloyd, Siobhan Creanor, Stuart Logan, Colin Green, Sarah G Dean, Melvyn Hillsdon, Charles Abraham, Richard Tomlinson, Virginia Pearson, Rod S Taylor, Emma Ryan, Lisa Price, Adam Streeter, Katrina Wyatt
Background: Although childhood overweight and obesity prevalence has increased substantially worldwide in the past three decades, scarce evidence exists for effective preventive strategies. We aimed to establish whether a school-based intervention for children aged 9-10 years would prevent excessive weight gain after 24 months. Methods: This pragmatic cluster randomised controlled trial of the Healthy Lifestyles Programme (HeLP), a school-based obesity prevention intervention, was done in 32 schools in southwest England...
January 2018: The lancet child & adolescent health
https://www.readbyqxmd.com/read/29302556/process-evaluation-of-child-health-services-at-outreach-sites-during-health-and-nutrition-day-mamta-day-in-urban-slums-of-western-india
#6
Kedar Mehta, Chandresh Pandya, Paragkumar Chavda, Dipak Solanki
Introduction: Health indicators of rural and urban India show a wide variation. Rural areas have received large focus in child health services, but on the flip side, urban areas have been the last to receive such attention. Materials and Methods: A cross-sectional study was conducted to include one randomly selected outreach session from all the 19 urban primary health centers of Vadodara city from April 2013 to May 2014. Nineteen session sites were observed for the process evaluation of three components of child health care, namely, "planning of Health and Nutrition Day," "availability of vaccines/logistics," and "direct observation of actual immunization process" at the site using a structured checklist...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29300620/tp53-germline-variations-influence-the-predisposition-and-prognosis-of-b-cell-acute-lymphoblastic-leukemia-in-children
#7
Maoxiang Qian, Xueyuan Cao, Meenakshi Devidas, Wenjian Yang, Cheng Cheng, Yunfeng Dai, Andrew Carroll, Nyla A Heerema, Hui Zhang, Takaya Moriyama, Julie M Gastier-Foster, Heng Xu, Elizabeth Raetz, Eric Larsen, Naomi Winick, W Paul Bowman, Paul L Martin, Elaine R Mardis, Robert Fulton, Gerard Zambetti, Michael Borowitz, Brent Wood, Kim E Nichols, William L Carroll, Ching-Hon Pui, Charles G Mullighan, William E Evans, Stephen P Hunger, Mary V Relling, Mignon L Loh, Jun J Yang
Purpose Germline TP53 variation is the genetic basis of Li-Fraumeni syndrome, a highly penetrant cancer predisposition condition. Recent reports of germline TP53 variants in childhood hypodiploid acute lymphoblastic leukemia (ALL) suggest that this type of leukemia is another manifestation of Li-Fraumeni syndrome; however, the pattern, prevalence, and clinical relevance of TP53 variants in childhood ALL remain unknown. Patients and Methods Targeted sequencing of TP53 coding regions was performed in 3,801 children from the Children's Oncology Group frontline ALL clinical trials, AALL0232 and P9900...
January 4, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29296872/chronic-disease-burden-and-frailty-in-survivors-of-childhood-hsct-a-report-from-the-st-jude-lifetime-cohort-study
#8
Hesham M Eissa, Lu Lu, Malek Baassiri, Nickhill Bhakta, Matthew J Ehrhardt, Brandon M Triplett, Daniel M Green, Daniel A Mulrooney, Leslie L Robison, Melissa M Hudson, Kirsten K Ness
Outcomes of hematopoietic stem cell transplantation (HSCT) have markedly improved over the past 2 decades, underscoring a need to better understand the long-term health effects of this intensive treatment modality. We describe the burden of chronic medical conditions and frail health among St. Jude Lifetime Cohort Study participants treated for childhood hematologic malignancies with HSCT (n = 112) or with conventional therapy (n = 1106). Chronic conditions and frail health were ascertained clinically and classified according to a modified version of the Common Terminology Criteria for Adverse Events (version 4...
November 14, 2017: Blood Advances
https://www.readbyqxmd.com/read/29295018/is-there-a-cumulative-association-between-adverse-childhood-experiences-and-intimate-partner-violence-in-emerging-adulthood
#9
Valentina Nikulina, Melissa Gelin, Amanda Zwilling
Adverse childhood experiences (ACEs) have been shown to cumulatively predict a range of poor physical and mental health outcomes across adulthood. The cumulative effect of ACEs on intimate partner violence (IPV) in emerging adulthood has not been previously explored. The current study examined the individual and cumulative associations between nine ACEs (emotional abuse, physical abuse, sexual abuse, emotional neglect, physical neglect, witnessing domestic violence, living with a mentally ill, substance abusing, or incarcerated household member) and IPV in a diverse sample of college students ( N = 284; Mage = 20...
December 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29288491/risk-factors-and-peripheral-biomarkers-for-schizophrenia-spectrum-disorders-an-umbrella-review-of-meta-analyses
#10
L Belbasis, C A Köhler, N Stefanis, B Stubbs, J van Os, E Vieta, M V Seeman, C Arango, A F Carvalho, E Evangelou
OBJECTIVE: This study aimed to systematically appraise the meta-analyses of observational studies on risk factors and peripheral biomarkers for schizophrenia spectrum disorders. METHODS: We conducted an umbrella review to capture all meta-analyses and Mendelian randomization studies that examined associations between non-genetic risk factors and schizophrenia spectrum disorders. For each eligible meta-analysis, we estimated the summary effect size estimate, its 95% confidence and prediction intervals and the I2 metric...
December 30, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29282090/pharmacokinetic-and-safety-profile-of-tofacitinib-in-children-with-polyarticular-course-juvenile-idiopathic-arthritis-results-of-a-phase-1-open-label-multicenter-study
#11
Nicolino Ruperto, Hermine I Brunner, Zbigniew Zuber, Nikolay Tzaribachev, Daniel J Kingsbury, Ivan Foeldvari, Gerd Horneff, Elzbieta Smolewska, Richard K Vehe, Anasuya Hazra, Rong Wang, Charles A Mebus, Christine Alvey, Manisha Lamba, Sriram Krishnaswami, Thomas C Stock, Min Wang, Ricardo Suehiro, Alberto Martini, Daniel J Lovell
BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease and a leading cause of childhood disability. The objective of this study was to characterize the PK, safety, and taste acceptability of tofacitinib in patients with JIA. METHODS: This Phase 1, open-label, multiple-dose (twice daily [BID] for 5 days) study of tofacitinib in patients with active (≥ 5 joints) polyarticular course JIA was conducted from March 2013-December 2015...
December 28, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29259822/efficacy-of-a-bovine-colostrum-and-egg-based-intervention-in-acute-childhood-diarrhoea-in-guatemala-a-randomised-double-blind-placebo-controlled-trial
#12
James T Gaensbauer, Mario A Melgar, Diva M Calvimontes, Molly M Lamb, Edwin J Asturias, Ingrid L Contreras-Roldan, Samuel R Dominguez, Christine C Robinson, Stephen Berman
Background: Treatments for paediatric diarrhoeal disease are limited. We assessed the impact of a bovine colostrum and egg-based treatment designed to reduce diarrhoea duration through non-specific and pathogen-directed mechanisms in children. Methods: Randomised, double-blind, placebo-controlled trial of PTM202, derived from bovine colostrum and hyperimmune hen's egg on the duration of acute diarrhoeal disease in Guatemalan children. PTM202 contains specific immunoglobulins that target rotavirus, enterotoxigenic Escherichia coli, Shiga toxin-producing E...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29249990/mediators-linking-childhood-adversities-and-trauma-to-suicidality-in-individuals-at-risk-for-psychosis
#13
Stefanie J Schmidt, Frauke Schultze-Lutter, Sarah Bendall, Nicola Groth, Chantal Michel, Nadja Inderbitzin, Benno G Schimmelmann, Daniela Hubl, Barnaby Nelson
Suicidality is highly prevalent in patients at clinical high risk (CHR) for psychosis. Childhood adversities and trauma are generally predictive of suicidality. However, the differential effects of adversity/trauma-domains and CHR-criteria, i.e., ultra-high risk and basic symptom criteria, on suicidality remain unclear. Furthermore, the underlying mechanisms and, thus, worthwhile targets for suicide-prevention are still poorly understood. Therefore, structural equation modeling was used to test theory-driven models in 73 CHR-patients...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29242840/the-mid-childhood-and-adolescent-antecedents-of-women-s-external-locus-of-control-orientation
#14
Jean Golding, Steven Gregory, Yasmin Iles-Caven, Stephen Nowicki
Background: External locus of control orientation (ELOC) is a powerful predictor of adverse consequences in regard to health, educational attainment, inter-personal relationships and well-being. Although many cross-sectional studies have been carried out, relatively little is known about antecedent factors influencing the development of ELOC. Methods: Over 12,000 pregnant women who enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC) in south-west England, had completed a brief version of the Adult Nowicki-Strickland Internal-External LOC scale, together with detailed questions concerning their own parents and childhood...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/29234981/sarcopenia-after-induction-therapy-in-childhood-acute-lymphoblastic-leukemia-its-clinical-significance
#15
Daisuke Suzuki, Ryoji Kobayashi, Hirozumi Sano, Daiki Hori, Kunihiko Kobayashi
Muscle weakness is one of the most serious problems during chemotherapy for childhood hematological malignancies. It may be caused by long-term hospitalization, unfavorable physical conditions, and restricted activities. Although the concept of sarcopenia is becoming widely recognized, especially in geriatric medicine, there have been few reports about sarcopenia in pediatric patients with hematological malignancies. A total of 47 consecutive first-onset acute lymphoblastic leukemia (ALL) patients who underwent induction therapy between January 2011 and September 2016 were investigated...
December 12, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29225904/late-stage-left-ventricular-dysfunction-in-adult-survivors-of-tetralogy-of-fallot-repair-in-childhood
#16
Abdel Anabtawi, Judith Mondragon, Diane Dodendorf, Warren K Laskey
Objective: Left ventricular systolic dysfunction (LVSD) in adult survivors of tetralogy of Fallot (TOF) repair in childhood has been observed, although the relationship with long-term outcome remains inadequately described. Methods: A cohort of 44 consecutive adult patients with TOF repair in childhood were followed prospectively from January 2001 through June 2016. LVSD was defined as an echocardiographically derived left ventricular (LV) ejection fraction <0...
2017: Open Heart
https://www.readbyqxmd.com/read/29225689/acute-myeloid-leukaemia-at-an-early-age-reviewing-the-interaction-between-pesticide-exposure-and-kmt2a-rerrangments
#17
REVIEW
Maria S Pombo-de-Oliveira, Francianne Gomes Andrade, Gisele Dallapicola Brisson, Filipe Vicente Dos Santos Bueno, Ingrid Sardou Cezar, Elda Pereira Noronha
Acute myeloid leukaemia (AML) in early childhood is characterised by a high frequency of recurrent genomic aberrations associated with distinct myeloid subtypes, clinical outcomes and pathogenesis. Genomic instability is the first step of pathogenic mechanism in early childhood AML. A sum of adverse events is necessary to the development of infant AML (i-AML), which includes latency of biochemical-molecular and cellular effects. Inherited genetic susceptibility associated with exposures to biotransformation substances can modulate the risk of DNA damage and it is a very important piece in the pathogenic puzzle...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29223440/outcomes-of-cardiac-pacing-in-adult-patients-after-a-fontan-operation
#18
Alexander C Egbe, Geoffery D Huntley, Heidi M Connolly, Naser M Ammash, Abhishek J Deshmukh, Arooj R Khan, Sameh M Said, Emmanuel Akintoye, Carole A Warnes, Suraj Kapa
BACKGROUND: Cardiac pacing can be challenging after a Fontan operation, and limited data exist regarding pacing in adult Fontan patients. The objectives of our study were to determine risk factors for pacing and occurrence of device-related complications (DRCs) and pacemaker reinterventions. METHODS: We performed a retrospective review of Fontan patients from 1994 through 2014. We defined DRCs as lead failure, lead recall, cardiac perforation, lead thrombus/vegetation, or device-related infection, and cardiovascular adverse events (CAEs) as venous thrombosis, stroke, death, or heart transplant...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29215455/the-relationship-between-childhood-trauma-and-poor-sleep-health-in-adulthood
#19
Ryan C Brindle, Matthew R Cribbet, Laura B Samuelsson, Chenlu Gao, Ellen Frank, Robert T Krafty, Julian F Thayer, Daniel J Buysse, Martica H Hall
OBJECTIVE: Childhood trauma has been related to adverse behavioral, mental, and health outcomes later in life. Sleep may be a potential mechanism through which childhood trauma is related to adverse health. The current retrospective study aimed to characterize the relationship between childhood trauma exposure and sleep health, a novel multidimensional measure of sleep. METHODS: Participants (N = 161; Mean(SD) age = 59.85(9.06); 67.7% female) retrospectively reported trauma exposure using the Trauma History Questionnaire...
December 5, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29213269/safety-and-immunogenicity-of-malaria-vectored-vaccines-given-with-routine-expanded-program-on-immunization-vaccines-in-gambian-infants-and-neonates-a-randomized-controlled-trial
#20
Victorine A Mensah, Sophie Roetynck, Ebrima K Kanteh, Georgina Bowyer, Amy Ndaw, Francis Oko, Carly M Bliss, Ya Jankey Jagne, Riccardo Cortese, Alfredo Nicosia, Rachel Roberts, Flavia D'Alessio, Odile Leroy, Babacar Faye, Beate Kampmann, Badara Cisse, Kalifa Bojang, Stephen Gerry, Nicola K Viebig, Alison M Lawrie, Ed Clarke, Egeruan B Imoukhuede, Katie J Ewer, Adrian V S Hill, Muhammed O Afolabi
Background: Heterologous prime-boost vaccination with chimpanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) encoding multiple epitope string thrombospondin-related adhesion protein (ME-TRAP) has shown acceptable safety and promising immunogenicity in African adult and pediatric populations. If licensed, this vaccine could be given to infants receiving routine childhood immunizations. We therefore evaluated responses to ChAd63 MVA ME-TRAP when co-administered with routine Expanded Program on Immunization (EPI) vaccines...
2017: Frontiers in Immunology
keyword
keyword
47247
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"