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https://www.readbyqxmd.com/read/28109057/comparison-of-two-biodegradable-polymer-based-sirolimus-eluting-stents-with-varying-elution-and-absorption-kinetics-in-patients-with-acute-myocardial-infarction-a-subgroup-analysis-of-the-panda-iii-trial
#1
Changdong Guan, Bo Xu, Shubin Qiao, Lei Qin, Yi Li, Zhanquan Li, Yong Guo, Zhongwei Sun, Lei Song, Runlin Gao
BACKGROUND: Implantation of early-generation metallic drug-eluting stents (DES) in patients with acute myocardial infarction (AMI) is associated with poor vessel wall healing. Use of biodegradable polymer (BP) DES might improve safety outcomes; however, the impact of varying drug elution and polymer absorption kinetics of BP-DES on clinical outcomes in the AMI population is unknown. METHODS: This subgroup analysis of the randomized PANDA III trial included 732 patients (366 in each group) presenting with recent (<1 month) AMI...
January 21, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28108466/post-glucose-load-measures-of-insulin-resistance-and-prognosis-of-nondiabetic-patients-with-ischemic-stroke
#2
Yuesong Pan, Jing Jing, Weiqi Chen, Huaguang Zheng, Qian Jia, Donghua Mi, Hao Li, Xingquan Zhao, Liping Liu, Chunxue Wang, Herbert Y Gaisano, Yan He, Yilong Wang, Yongjun Wang
BACKGROUND: Insulin resistance is associated with an increased risk of cardiovascular events in the general population. This study aimed to estimate the association between post-glucose load measures of insulin resistance and prognosis of nondiabetic patients with ischemic stroke. METHODS AND RESULTS: Data were derived from the ACROSS-China (Abnormal Glucose Regulation in Patients with Acute Stroke across China) registry. Patients with ischemic stroke without a history of diabetes mellitus were included...
January 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28107888/anxiety-and-anger-immediately-prior-to-myocardial-infarction-and-long-term-mortality-characteristics-of-high-risk-patients
#3
Loes Smeijers, Elizabeth Mostofsky, Geoffrey H Tofler, James E Muller, Willem J Kop, Murray A Mittleman
OBJECTIVE: Acute high levels of anger and anxiety are associated with an elevated risk of myocardial infarction (MI) in the following two hours. MIs preceded by these acute negative emotions may also have a poor long-term prognosis, but information about high-risk patients is lacking. We examined whether young age and female sex are associated with MIs that are preceded by negative emotions and whether age and sex moderate the subsequent increased mortality risk following MI preceded by negative emotions...
February 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28105763/triggering-of-acute-myocardial-infarction-by-respiratory-infection
#4
Lorcan Ruane, Thomas Buckley, Soon Y Soo Hoo, Peter S Hansen, Catherine McCormack, Elizabeth Shaw, Judith Fethney, Geoffrey H Tofler
BACKGROUND: Respiratory infection has been associated with an increased short term risk of myocardial infarction (MI). However, previous studies have predominantly been conducted without angiographic confirmation of MI. The possibility can therefore not be excluded that raised troponin levels or electrocardiogram abnormalities that may be seen with respiratory infections are due to non-ischaemic causes. AIMS: To investigate the association between respiratory infection and angiographically confirmed MI...
January 20, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28105343/increased-complements-and-high-sensitivity-c-reactive-protein-predict-heart-failure-in-acute-myocardial-infarction
#5
Danni Liu, Xin Qi, Qi Li, Wenjun Jia, Liping Wei, Anan Huang, Keqiang Liu, Zongjin Li
The aim of the present study was to investigate whether the serum levels of complements and high-sensitivity C-reactive protein (hs-CRP) in patients with acute myocardial infarction (AMI) are associated with the severity of myocardial injury. Consecutive patients (n=110) with AMI and 33 healthy individuals, who served as control subjects, were enrolled from May 2013 to February 2015. These patients were divided into two groups, those with ST segment elevation MI (STEMI) and those with non-ST segment elevation MI (NSTEMI)...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28105138/clinical-and-angiographic-correlation-of-high-sensitivity-c-reactive-protein-with-acute-st-elevation-myocardial-infarction
#6
Syed Tanveer, Shaheena Banu, Nasimudeen Rehumathbeevi Jabir, Mohd Shahnawaz Khan, Ghulam Md Ashraf, Nanjappa Cholenahally Manjunath, Shams Tabrez
Vascular inflammation and associated ongoing inflammatory responses are considered as the critical culprits in the pathogenesis of acute atherothrombotic events such as acute coronary syndrome (ACS) and myocardial infarction (MI). ST segment elevation myocardial infarction (STEMI) is considered as one of the prominent clinical forms of ACS. Moreover, C-reactive protein (CRP) is an important acute phase prsotein, which may be estimated using high-sensitivity methods (hs-CRP), and its elevated level in body fluids reflects chronic inflammatory status...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28100208/access-to-primary-health-care-for-acute-vascular-events-in-rural-low-income-settings-a-mixed-methods-study
#7
Shyfuddin Ahmed, Muhammad Ashique Haider Chowdhury, Md Alfazal Khan, Nafisa Lira Huq, Aliya Naheed
BACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of global mortality. Among the CVDs, acute vascular events (AVE) mainly ischemic heart diseases and stroke are the largest contributors. To achieve 25% reduction in preventable deaths from CVDs by 2025, health systems need to be equipped with extended service coverage in order to provide person-centered care. The overall goal of this proposed study is to assess access to health care in-terms of service availability, care seeking patterns and barriers to access care after AVE in rural Bangladesh...
January 18, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28099589/which-coronary-lesions-are-more-prone-to-cause-acute-myocardial-infarction
#8
Taner Sen, Mehmet Ali Astarcioglu, Osman Beton, Lale Dinc Asarcikli, Celal Kilit
Background: According to common belief, most myocardial infarctions (MIs) are due to the rupture of nonsevere, vulnerable plaques with < 70% obstruction. Data from recent trials challenge this belief, suggesting that the risk of coronary occlusion is, in fact, much higher after severe stenosis. The aim of this study was to investigate whether or not acute ST-elevation MIs result from high-grade stenoses by evaluating the presence of coronary collateral circulation (CCC). Methods: We retrospectively included 207 consecutive patients who had undergone primary percutaneous coronary intervention for acute ST-elevation MI...
January 16, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28098247/c-jun-n-terminal-kinase-2-promotes-enterocyte-survival-and-goblet-cell-differentiation-in-the-inflamed-intestine
#9
A D Mandić, E Bennek, J Verdier, K Zhang, S Roubrocks, R J Davis, B Denecke, N Gassler, K Streetz, A Kel, M Hornef, F J Cubero, C Trautwein, G Sellge
c-Jun N-terminal kinases (JNKs) contribute to immune signaling but their functional role during intestinal mucosal inflammation has remained ill defined. Using genetic mouse models, we characterized the role of JNK1 and JNK2 during homeostasis and acute colitis. Epithelial apoptosis, regeneration, differentiation, and barrier function were analyzed in intestinal epithelium-specific (ΔIEC) or complete JNK1 and bone marrow chimeric or complete JNK2 deficient mice as well as double-knockout animals (JNK1(ΔIEC)JNK2(-/-)) during homeostasis and acute dextran sulfate sodium (DSS)-induced colitis...
January 18, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28097005/the-cardioprotective-efficacy-of-tvp1022-against-ischemia-reperfusion-injury-and-cardiac-remodeling-in-rats
#10
Assaf Malka, Offir Ertracht, Noa Bachner-Hinenzon, Irina Reiter, Ofer Binah
Following acute myocardial infarction (MI), early and successful reperfusion is the most effective strategy for reducing infarct size and improving the clinical outcome. However, immediate restoration of blood flow to the ischemic zone results in myocardial damage, defined as "reperfusion-injury". Whereas we previously reported that TVP1022 (the S-isomer of rasagiline, FDA-approved anti-Parkinson drug) decreased infarct size 24 h post ischemia reperfusion (I/R) in rats, in this study we investigated the chronic cardioprotective efficacy of TVP1022 14 days post-I/R...
December 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28096451/quantitative-relationships-between-lacz-mutant-frequency-and-dna-adduct-frequency-in-muta%C3%A2-mouse-tissues-and-cultured-cells-exposed-to-3-nitrobenzanthrone
#11
Paul A White, George R Douglas, David H Phillips, Volker M Arlt
The frequency of stable DNA adducts in a target tissue can be used to assess biologically effective dose; however, the utility of the metric in a risk assessment context depends on the likelihood that the DNA damage will be manifested as mutation. Previously, we employed the Muta™Mouse system to examine the induction of lacZ mutants and DNA adducts following exposure to the well-studied mutagenic carcinogen 3-nitrobenzanthrone (3-NBA). In this follow-up work, we examined the empirical relationships between total adduct frequency and mutant frequency (MF) in tissues and cultured cells following acute 3-NBA exposure...
January 16, 2017: Mutagenesis
https://www.readbyqxmd.com/read/28094581/early-immunopathological-events-in-acute-model-of-mycobacterial-hypersensitivity-pneumonitis-in-mice
#12
Elisabet Johansson, Gregory P Boivin, Jagjit S Yadav
Prolonged exposure to antigens of non-tuberculous mycobacteria species colonizing industrial metalworking fluid (MWF), particularly Mycobacterium immunogenum (MI), has been implicated in chronic forms of hypersensitivity pneumonitis (HP) in machinists based on epidemiology studies and long-term exposure of mouse models. However, a role of short-term acute exposure to these antigens has not been described in the context of acute forms of HP. This study investigated short-term acute exposure of mice to MI cell lysate (or live cell suspension) via oropharyngeal aspiration...
January 17, 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/28094123/myocardial-and-serum-galectin-3-expression-dynamics-marks-post-myocardial-infarction-cardiac-remodelling
#13
Umesh C Sharma, Wassim Mosleh, Milind R Chaudhari, Rujuta Katkar, Brian Weil, Chris Evelo, Thomas R Cimato, Saraswati Pokharel, W Matthijs Blankesteijn, Gen Suzuki
BACKGROUND: Acute myocardial infarction (MI) causes significant changes in cardiac morphology and function. Galectin-3 is a novel and potentially therapeutically important mediator of cardiac remodelling. Myocardial and serum galectin-3 expression dynamics in response to the early cardiovascular outcomes after acute MI are not fully elucidated. METHODS: We first performed a comprehensive longitudinal microarray analyses in mice after acute MI. We then measured the serum levels of galectin-3 in a translational porcine model of coronary microembolism-induced post-ischaemic cardiac remodelling...
December 19, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28091702/platelet-receptor-gene-p2y12-p2y1-and-platelet-glycoprotein-gene-gpiiia-polymorphisms-are-associated-with-antiplatelet-drug-responsiveness-and-clinical-outcomes-after-acute-minor-ischemic-stroke
#14
Xingyang Yi, Qiang Zhou, Chun Wang, Jing Lin, Ping Liu, Cheng Fu
PURPOSE: Patients with minor ischemic stroke (MIS) are at high risk of recurrent ischemic stroke (RIS). The aim of this study was to evaluate the effects of platelet receptor gene (P2Y12, P2Y1) and glycoprotein gene (GPIIIa) polymorphisms, as well as their interactions, on antiplatelet drug responsiveness and clinical outcomes in patients with acute MIS. METHODS: We prospectively enrolled 426 patients with acute MIS who had been receiving combined aspirin and clopidogrel treatment for at least 3 months...
January 13, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28090071/impact-of-morning-onset-on-the-incidence-of-recurrent-acute-coronary-syndrome-and-progression-of-coronary-atherosclerosis-in-acute-myocardial-infarction
#15
Hiroshi Nakashima, Yuka Mashimo, Masaya Kurobe, Shigenori Muto, Shinnosuke Furudono, Koji Maemura
BACKGROUND: The relationship between time of onset of acute myocardial infarction (MI) and long-term clinical outcome has not been completely understood. We hypothesized that morning onset acute MI may be associated with adverse cardiac events.Methods and Results:This study involved 663 patients who underwent primary percutaneous coronary intervention (PCI). The main outcome measures were cardiac death, recurrent acute coronary syndrome (ACS), and re-hospitalization for heart failure...
January 13, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28089789/differing-clinical-characteristics-between-young-and-older-patients-presenting-with-myocardial-infarction
#16
Kyriakos Matsis, Ana Holley, Ali Al-Sinan, Phillip Matsis, Peter D Larsen, Scott A Harding
BACKGROUND: To date, there has been no detailed study of the risk factors and clinical characteristics of patients presenting with myocardial infarction (MI) at a young age in our region. The purpose of this study was to assess the rate and clinical profile of those presenting with young MI in New Zealand. METHODS: We identified a cohort of 1199 patients presenting with acute MI between January 2012 and November 2015 from the Wellington Acute Coronary Syndrome Registry...
November 11, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28089149/fasting-glucose-nt-probnp-treatment-with-eptifibatide-and-outcomes-in-non-st-segment-elevation-acute-coronary-syndromes-an-analysis-from-early-acs
#17
Serdar Farhan, Robert M Clare, Rudolf Jarai, Robert P Giugliano, Yuliya Lokhnygina, Robert A Harrington, L Kristin Newby, Kurt Huber
BACKGROUND: Higher N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels have been linked to a more favorable glucometabolic profile. Little is known about the interaction of NT-proBNP and fasting glucose in non-ST-segment elevation acute coronary syndrome (NSTE ACS). METHODS: Fasting glucose and NT-proBNP were measured in 2240 patients enrolled in the EARLY ACS trial. Multivariable Cox models were used to assess associations between fasting glucose and NT-proBNP and a 96-hour composite of death, myocardial infarction (MI), recurrent ischemia, or thrombotic bailout; 30-day death or MI; and 1-year mortality...
January 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28088961/-the-clinical-and-prognostic-significance-of-acute-myeloid-leukemia-with-flt3-itd
#18
D Lin, H Wei, Y Wang, C L Zhou, B C Liu, K Q Liu, B F Gong, S N Wei, G J Zhang, Y T Liu, X Y Gong, S W Qiu, Y C Mi, J X Wang
Objective: To investigate the clinical significance and prognosis factors of acute myeloid leukemia (AML) with FLT3 mutation-internal tandem duplication (FLT3-ITD) and provide more evidence for prognosis evaluation in AML with FLT3-ITD. Methods: The clinical characteristics and outcomes of 98 AML with FLT3-ITD were analyzed. Results: In patients with FLT3-ITD positive AML, the median of WBC and peripheral blood blast at initial diagnosis were 58.2 (0.3-461.8) ×10(9)/L and 42.2 (0-397.1) ×10(9)/L, respectively...
December 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28086859/cheongsangbangpung-tang-ameliorated-the-acute-inflammatory-response-via-the-inhibition-of-nf-%C3%AE%C2%BAb-activation-and-mapk-phosphorylation
#19
Seon Young Kim, Sang Mi Park, Min Hwangbo, Jong Rok Lee, Sung Hui Byun, Sae Kwang Ku, Il Je Cho, Sang Chan Kim, Seon Young Jee, Sook Jahr Park
BACKGROUND: Cheongsangbangpung-tang (CBT) is a traditional herbal formula used in Eastern Asia to treat heat-related diseases and swellings in the skin. The present study was conducted to evaluate the anti-inflammatory effects of cheongsangbangpung-tang extract (CBTE) both in vitro and in vivo. METHODS: The in vitro effects of CBTE on the lipopolysaccharide (LPS)-induced production of inflammation-related proteins were examined in RAW 264.7 cells. The levels of nitric oxide (NO) were measured with the Griess reagent...
January 13, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28078714/percutaneous-closure-of-post-infarction-ventricular-septal-defects-an-over-decade-long-experience
#20
Robert Sabiniewicz, Zenon Huczek, Karol Zbroński, Piotr Scisło, Bartosz Rymuza, Janusz Kochman, Miłosz Marć, Marek Grygier, Aleksander Araszkiewicz, Mieczysław Dziarmaga, Piotr Leśniewicz, Jarosław Hiczkiewicz, Michał Kidawa, Krzysztof J Filipiak, Grzegorz Opolski
OBJECTIVES: To report an over decade-long experience with percutaneous post-infarction ventricular septal defect (PIVSD) closure. BACKGROUND: PIVSDs remains a major clinical challenge with extremely high mortality. Data concerning interventional closure of PIVSD is scarce. METHODS: All percutaneous PIVSD closures performed between 2003 and 2016 in 8 participating centres were identified. Data concerning patients and procedures was acquired...
January 11, 2017: Journal of Interventional Cardiology
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