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Taxus baccata

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https://www.readbyqxmd.com/read/28941873/extracorporeal-life-support-and-digoxin-specific-fab-fragments-for-successful-management-of-taxus-baccata-intoxication-with-low-output-and-ventricular-arrhythmia
#1
Mina Farag, Dominika Badowski, Ronald Koschny, Gisela Skopp, Andreas Brcic, Gabor B Szabo
INTRODUCTION: Yew plants are evergreen shrubs which are widely spread throughout the northern hemisphere. Taxane alkaloid derivatives, mainly taxine B, represent the main toxins of Taxus baccata and are highly cardiotoxic. Due to the lack of randomized clinical trials, case reports on accidental or suicidal yew intoxications build the only source of knowledge of clinical treatment options. CASE REPORT: We report the case of a suicidal yew ingestion admitted to our hospital under prolonged cardiopulmonary resuscitation due to pulseless electrical activity...
September 18, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28928475/isolation-of-the-antibiotic-methyl-r-e-3-1-hydroxy-4-oxocyclopent-2-en-1-yl-acrylate-ea-2801-from-trichoderma-atroviridae
#2
Emilie Adelin, Géraldine Le Goff, Pascal Retailleau, Mercedes Bonfill, Jamal Ouazzani
The endophytic Trichoderma atroviridae UB-LMA was isolated as a symbiont of Taxus baccata and analyzed for its antimicrobial activity. By applying an original approach consisting of solid-state cultivation coupled with solid-phase extraction, a new methyl (R,E)-3-(1-hydroxy-4-oxocyclopent-2-en-1-yl)-acrylate derivative named EA-2801 (1) was isolated together with the previously reported isonitrin A and dermadin methyl ester. The chemical structure of 1 was determined by NMR and MS. Compound 1 showed antimicrobial activity against a panel of Gram-positive and -negative bacteria...
September 20, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28865388/post-mortem-findings-in-22-fatal-taxus-baccata-intoxications-and-a-possible-solution-to-its-detection
#3
REVIEW
Guido Reijnen, Corine Bethlehem, Jacquo M B L van Remmen, Hans J M Smit, Matthijs van Luin, Udo J L Reijnders
BACKGROUND: The yew (Taxus baccata) is a common evergreen tree containing the toxin taxine B. Between 42 and 91 g of yew leaf is lethal to a 70-kg adult. The objective of this article is to present an overview of findings in fatal yew intoxications. METHODS: A search using MeSH terms was performed in PubMed for yew intoxications in the period between January 1960 and August of 2016. RESULTS: We describe a total of 22 cases. Fatal intoxications can be divided into intoxications by leaves, by pulp, by bark and by yew tea...
August 25, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28795267/cyp79-p450-monooxygenases-in-gymnosperms-cyp79a118-is-associated-with-the-formation-of-taxiphyllin-in-taxus-baccata
#4
Katrin Luck, Qidong Jia, Meret Huber, Vinzenz Handrick, Gane Ka-Shu Wong, David R Nelson, Feng Chen, Jonathan Gershenzon, Tobias G Köllner
Conifers contain P450 enzymes from the CYP79 family that are involved in cyanogenic glycoside biosynthesis. Cyanogenic glycosides are secondary plant compounds that are widespread in the plant kingdom. Their biosynthesis starts with the conversion of aromatic or aliphatic amino acids into their respective aldoximes, catalysed by N-hydroxylating cytochrome P450 monooxygenases (CYP) of the CYP79 family. While CYP79s are well known in angiosperms, their occurrence in gymnosperms and other plant divisions containing cyanogenic glycoside-producing plants has not been reported so far...
August 9, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28590987/-chaotic-arrhythmia-during-successful-resuscitation-after-ingestion-of-yew-taxus-baccata-needles
#5
Andreas Zutter, Kathrin Hauri, Katrina S Evers, Sabine Uhde, Jens Fassl, Oliver Tobias Reuthebuch, Andreas Berset, Michael Kühne, Birgit C Donner
OBJECTIVE: The study aims to describe the management of a case of life-threatening yew (Taxus baccata) intoxication. BACKGROUND: The needles of the yew tree contain highly cardiotoxic taxines. Intoxication with taxines, typically as part of suicide attempts, may lead to potentially lethal arrhythmias which often require prolonged cardiopulmonary resuscitation and other supportive measures. No specific therapy has been described. In some cases, extracorporeal life support has been used...
June 6, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28523824/laser-desorption-ionisation-mass-spectrometry-imaging-of-european-yew-taxus-baccata-on-gold-nanoparticle-enhanced-target
#6
Adrian Arendowski, Tomasz Ruman
INTRODUCTION: European yew (Taxus baccata) is a plant known to man for centuries as it produces many interesting and important metabolites. These chemical compounds were repeatedly analysed by various analytical techniques, but none of the methods used so far allowed the localisation of the chemical compounds within the tissue and also correlation between plant morphology and its biochemistry. OBJECTIVE: Visualisation of the spatial distribution of yew metabolites with nanoparticle-based mass spectrometry imaging...
May 19, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28494178/suicide-attempt-with-self-made-taxus-baccata-leaf-capsules-survival-following-the-application-of-extracorporeal-membrane-oxygenation-for-ventricular-arrythmia-and-refractory-cardiogenic-shock
#7
Fanny Vardon Bounes, Elsa Tardif, Stéphanie Ruiz, Jean-Christophe Gallart, Jean-Marie Conil, Clément Delmas
CONTEXT: Yew intoxication has been known for many years; high dose ingestion of Taxus baccata leads to cardiac toxicity mediated by calcium and sodium channel blocking properties. We present a case report of a patient who attempted suicide after T. baccata ingestion, causing refractory cardiogenic shock requiring temporary circulatory assistance by veno-arterial extra corporeal membrane oxygenation (VA ECMO). CASE DETAILS: A 28-year-old man was admitted to the critical care unit of a university hospital for arrhythmia after ingestion of self-made T...
September 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28332162/isolation-of-taxol-producing-endophytic-fungi-from-iranian-yew-through-novel-molecular-approach-and-their-effects-on-human-breast-cancer-cell-line
#8
Abdollah Kasaei, Mohsen Mobini-Dehkordi, Foruzandeh Mahjoubi, Behnaz Saffar
Taxol or paclitaxel, an approved drug by the Food and Drug Administration, is being used for the treatment of human cancers. This study aimed to isolate and determine different species of native endophytic fungi from Iranian Taxus baccata (yew) plants located in the northern forests of Iran. To do so, a novel molecular screening approach was performed for 50 isolated endophytic fungi through amplification of exon No. 1 of taxadine synthase as a key gene in taxol production pathway. We used effective colony-polymerase chain reaction technique for rapid screening of potent taxol-producing fungi instead of genomic DNA extraction...
March 23, 2017: Current Microbiology
https://www.readbyqxmd.com/read/27784939/fusarium-tricinctum-an-endophytic-fungus-exhibits-cell-growth-inhibition-and-antioxidant-activity
#9
M Vasundhara, Manoj Baranwal, Anil Kumar
An endophytic fungus (strain T6) isolated from Taxus baccata was studied for its effect on the growth of human breast cancer cell line (MCF-7), human cervical cancer cell line (HeLa) and peripheral blood mononuclear cells (PBMCs) as well as for its antioxidant activity. Based on morphological characters and internal transcribed spacer (ITS) sequence analysis, this fungus (strain T6) was identified as Fusarium tricinctum. This fungus has shown inhibition in the growth of the MCF-7 and HeLa cancer cell lines...
December 2016: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/27783122/development-of-an-analytical-method-to-determine-oxy-pahs-and-pahs-in-taxus-baccata-leaves
#10
Christophe Walgraeve, Patrick De Wispelaere, Fé Van der Elst, Herman Van Langenhove
An analytical method was developed and optimized for the quantification of 16 polycyclic aromatic hydrocarbons (PAHs) and 12 oxygenated PAHs in Taxus baccata leaves. Emphasis was given to the development of an in-cell cleanup step using pressurized solvent extraction, a cleanup step using solid-phase extraction, and the instrumental analysis by GC-HRMS. Different extraction temperatures (between 50 and 200 °C) and Florisil quantities were evaluated for the extraction process. Based on the evaluation of both recoveries and matrix effect factors, a temperature of 200 °C and 1 g Florisil was selected as the optimum...
January 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27577698/a-suicide-attempt-by-intoxication-with-taxus-baccata-leaves-and-ultra-fast-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry-analysis-of-patient-serum-and-different-plant-samples-case-report
#11
Małgorzata Kobusiak-Prokopowicz, Anna Marciniak, Sylwester Ślusarczyk, Krzysztof Ściborski, Aneta Stachurska, Andrzej Mysiak, Adam Matkowski
BACKGROUND: Taxus (yew) is one of the most frequently reported plants causing potentially fatal outcome when taken incidentally or for suicidal reasons. A fast and reliable method of detection of poisonous compounds or their metabolites is critical in life-saving procedures in cases of yew ingestion. Previously, several chromatographic analytical procedures have been described usually taking longer than one hour of total analysis time. CASE PRESENTATION: In this report we describe a suicide case study and an ad hoc developed fast method of detection and quantitation of 3,5-dimethoxyphenol - the main taxane metabolite in the blood plasma from the patient as well as the determination of major taxine components in the plant material (Taxus baccata)...
2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27577692/relative-strength-of-fine-scale-spatial-genetic-structure-in-paternally-vs-biparentally-inherited-dna-in-a-dioecious-plant-depends-on-both-sex-proportions-and-pollen-to-seed-dispersal-ratio
#12
I J Chybicki, M Dering, G Iszkuło, K Meyza, J Suszka
In plants, the spatial genetic structure (SGS) is shaped mainly by gene dispersal and effective population density. Among additional factors, the mode of DNA inheritance and dioecy influence SGS. However, their joint impact on SGS remains unclear, especially in the case of paternally inherited DNA. Using theoretical approximations and computer simulations, here we showed that the relative intensity of SGS measured in paternally and biparentally inherited DNA in a dioecious plant population depends on both the proportion of males and the pollen-to-seed dispersal ratio...
December 2016: Heredity
https://www.readbyqxmd.com/read/27436403/fatal-taxus-baccata-ingestion-with-perimortem-serum-taxine-b-quantification
#13
Ann M Arens, Tiffany C Anaebere, Howard Horng, Kent Olson
INTRODUCTION: Common yew (Taxus baccata) is a common decorative evergreen shrub with potentially fatal toxicity hallmarked by seizure, arrhythmia and cardiovascular collapse if ingested. Taxine B has been identified as one of the most cardiotoxic taxine alkaloids in Taxus spp, and another alkaloid, 3,5-dimethoxyphenol (3,5-DMP), is used as a marker of ingestion. We present a fatal case of ingestion of yew with perimortem serum and gastric taxine B, and 3,5-DMP concentrations. CASE PRESENTATION: A 22-year-old woman was brought to the emergency department (ED) from a nearby botanical garden after she was found apneic and pulseless after a witnessed generalized tonic clonic seizure...
November 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27344572/endophytic-streptomyces-sp-ac35-a-producer-of-bioactive-isoflavone-aglycones-and-antimycins
#14
P Ondrejíčková, M Šturdíková, A Hushegyi, E Švajdlenka, K Markošová, M Čertík
In this research, a microbial endophytic strain obtained from the rhizosphere of the conifer Taxus baccata and designated as Streptomyces sp. AC35 (FJ001754.1 Streptomyces, GenBank) was investigated. High 16S rDNA gene sequence similarity suggests that this strain is closely related to S. odorifer. The major fatty acid profile of intracellular lipids was also carried out to further identify this strain. Atomic force microscopy and scanning acoustic microscopy were used to image our strain. Its major excreted substances were extracted, evaluated for antimicrobial activity, purified, and identified by ultraviolet-visible spectroscopy (UV-vis), liquid chromatography-mass spectrometry (LC-MS/MS) and nuclear magnetic resonance as the bioactive isoflavone aglycones-daidzein, glycitein and genistein...
September 2016: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27286568/chemical-composition-and-interpopulation-variability-of-essential-oils-of-taxus%C3%A2-baccata-l-from-serbia
#15
Milena Stefanović, Mihailo Ristić, Zorica Popović, Rada Matić, Biljana Nikolić, Vera Vidaković, Dragica Obratov-Petković, Srdjan Bojović
The composition of the essential oil of the twigs and needles of Taxus baccata L. from three natural populations in Serbia has been determined by GC/MS analysis. Of the 91 detected compounds, 87 were identified. The most abundant compound classes were aliphatic alcohols, terpenes, aliphatic hydrocarbons, and aliphatic aldehydes, which together comprised ca. 86.92% of the total oil composition. The dominant constituents were oct-1-en-3-ol (23.48%), (3Z)-hex-3-en-1-ol (11.46%; aliphatic alcohols), and myrtenol (11...
July 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27114581/how-does-the-functional-diversity-of-frugivorous-birds-shape-the-spatial-pattern-of-seed-dispersal-a-case-study-in-a-relict-plant-species
#16
Jessica E Lavabre, Luis J Gilarranz, Miguel A Fortuna, Jordi Bascompte
Genetic markers used in combination with network analysis can characterize the fine spatial pattern of seed dispersal and assess the differential contribution of dispersers. As a case study, we focus on the seed dispersal service provided by a small guild of frugivorous birds to the common yew, Taxus baccata L., in southern Spain. We build the spatial networks of seed dispersal events between trees and seed-plots within the studied population-local network-and the spatial network that includes all dispersal events-regional network...
May 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/26903309/slippery-when-sticky-lubricating-properties-of-thin-films-of-taxus-baccata-aril-mucilage
#17
Troels Røn, Sankaranarayanan Rishikesan, Ioannis S Chronakis, Seunghwan Lee
Mucilage is hydrogel produced from succulent plants and microorganisms displaying unique adhesiveness and slipperiness simultaneously. The objective of this study is to establish an understanding on the lubricating mechanisms of the mucilage from Taxus baccata aril as thin, viscous lubricant films. Oscillation and flow rheological studies revealed that T. baccata mucilage is shear-thinning, thixotropic, and weak hydrogel that is highly stretchable under shear stress due to its high density physical crosslinking characteristics...
March 22, 2016: Biointerphases
https://www.readbyqxmd.com/read/26883228/seasonal-based-temporal-changes-fluctuate-expression-patterns-of-txs-dbat-bapt-and-dbtnbt-genes-alongside-production-of-associated-taxanes-in-taxus-baccata
#18
Jaber Nasiri, Mohammad Reza Naghavi, Houshang Alizadeh, Mohammad Reza Fattahi Moghadam
Environmental cues have synergistic or antagonistic regulatory roles on transcription activity and taxanes accumulation in yew, though DBAT activity is less influenced, could be accordingly a rate-limiting enzyme. The current work was undertaken to elucidate the consequences of some environmental cues (i.e., day length, temperature, sunlight and relative humidity) on the expression patterns of TXS, DBAT, BAPT and DBTNBT genes contributed to the taxol biosynthetic pathway along with the accumulation of some taxanes in needles and stems of Taxus baccata over year 2013-2014...
May 2016: Plant Cell Reports
https://www.readbyqxmd.com/read/26466877/isolation-identification-and-ecology-of-growth-and-taxol-production-by-an-endophytic-strain-of-paraconiothyrium-variabile-from-english-yew-trees-taxus-baccata
#19
Supunnika Somjaipeng, Angel Medina, Hanna Kwaśna, Jose Ordaz Ortiz, Naresh Magan
Endophytic fungi were isolated/screened from temperate Taxus baccata (Yew) for production of the anti-cancer drug taxol. Of 242 endophytic fungi isolated from surface-sterilised Yew tree twig segments, only two produced taxol in a defined liquid medium; confirmed by HPLC and LC-MS/MS analyses. They were identified by molecular means by sequencing of ITS1/ITS2 regions and shown to be Paraconiothyrium variabile and Epicoccum nigrum. They produced 1.75 and 1.32 μgL(-1) taxol respectively in a defined medium. Studies focussed on the P...
November 2015: Fungal Biology
https://www.readbyqxmd.com/read/26096330/adapting-through-glacial-cycles-insights-from-a-long-lived-tree-taxus-baccata
#20
Maria Mayol, Miquel Riba, Santiago C González-Martínez, Francesca Bagnoli, Jacques-Louis de Beaulieu, Elisa Berganzo, Concetta Burgarella, Marta Dubreuil, Diana Krajmerová, Ladislav Paule, Ivana Romšáková, Cristina Vettori, Lucie Vincenot, Giovanni G Vendramin
Despite the large body of research devoted to understanding the role of Quaternary glacial cycles in the genetic divergence of European trees, the differential contribution of geographic isolation and/or environmental adaptation in creating population genetic divergence remains unexplored. In this study, we used a long-lived tree (Taxus baccata) as a model species to investigate the impact of Quaternary climatic changes on genetic diversity via neutral (isolation-by-distance) and selective (isolation-by-adaptation) processes...
November 2015: New Phytologist
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