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Aquaporin obstetrics

C Prat, D Bouvier, A Comptour, G Marceau, C Belville, G Clairefond, P Blanc, D Gallot, L Blanchon, V Sapin
INTRODUCTION: The aquaporins (AQP1, 3, 8, 9 and 11) are known to be expressed, and involved in the transport of water and small molecules through fetal membranes. To exert these crucial functions, these AQPs have to be finely regulated. All-trans-retinoic acid (atRA) was previously found to regulate some genes in this environment, raising the question of whether these AQPs were regulated by atRA. METHODS: Explants, and primary and established amniotic cells were cultured to determine which AQP were transcriptionally modified by atRA, using the qRT-PCR strategy...
August 2015: Placenta
Cécile Prat, Loïc Blanchon, Valérie Borel, Denis Gallot, Alain Herbet, Damien Bouvier, Geoffroy Marceau, Vincent Sapin
It has been proposed that four members of the aquaporin family (AQPs 1, 3, 8, and 9) are involved in the control of amniotic fluid (AF) homeostasis, as illustrated by their differential expression patterns in normal and pathological human term fetal membranes. However, there are no data available to date on their ontogeny throughout pregnancy. Our objective was to determine spatiotemporal expression profiles of the mRNA and proteins of all 13 members of this transmembrane channel family. For this purpose, we used healthy fetal membranes from the first, second, and third trimesters of pregnancy...
February 2012: Biology of Reproduction
L Blanchon, G Marceau, V Borel, C Prat, A Herbet, D Bouvier, D Gallot, V Sapin
Retinoids (active derivatives of vitamin A) were already demonstrated to be important morphogenes and their implication at the placental and fetal level was already established. A new field of research is now developed in order to show their role on fetal membranes constituted by amnion and chorion. To describe the role of retinoids on these membranes, our studies were focused on target gene research. Firstly, all metabolism enzymes needed to vitamin A pathways were demonstrated to be present and active in signal transduction...
June 2011: Gynécologie, Obstétrique & Fertilité
Asgeir Thoroddsen, Pernilla Dahm-Kähler, Anna Karin Lind, Birgitta Weijdegård, Bernhard Lindenthal, Jörg Müller, Mats Brännström
CONTEXT: Changes in vascular permeability and expansion of the fluid-filled antrum are major events in the LH-induced ovulatory process. OBJECTIVES: Our objective was to investigate the presence and expression levels of aquaporins (AQPs) in the granulosa and theca cell compartments of the follicle during defined phases of human ovulation. DESIGN AND SETTING: We conducted a prospective experimental study at the Department of Obstetrics and Gynaecology at a university hospital...
April 2011: Journal of Clinical Endocrinology and Metabolism
P Skapinec, M Kacerovský
OBJECTIVE: The purpose of this study was to focuse on aquaporins and their role in the regulation of amniotic fluid circulation. DESIGN: Review. SETTING: Department of Obstetrics and Gynecology Medical Faculty Charles University Hradec Kralove. METHODS: The summary about aquaporins which were first described as channels increased permeability of lipid membranes to water in response to osmotic and/or hydrostatic gradients...
April 2010: Ceská Gynekologie
Xiu-Xiu Jiang, Riu-Jin Wu, Kai-Hong Xu, Cai-Yun Zhou, Xiao-Yan Guo, Ya-Li Sun, Jun Lin
OBJECTIVE: To investigate the expression of aquaporin (AQP) in eutopic and ectopic endometrial tissues from women with endometriomas. DESIGN: Controlled laboratory research. SETTING: Hospital-based unit for gynecology and obstetrics and research laboratories. PATIENT(S): Premenopausal women undergoing laparoscopy for endometriomas. INTERVENTION(S): Endometrial biopsy samples obtained from 70 women with endometriomas...
September 2010: Fertility and Sterility
B Michalewska, M Wielgos, B Zupanska, R Bartkowiak
The Colton (Co(a)) antigen is of high frequency; its incidence in Caucasians is about 99.8%. Reports on haemolytic transfusion reactions and haemolytic disease of the foetus/newborn (HDFN) due to anti-Co(a) are rare. We report a severe HDFN due to anti-Co(a). The first child of the mother was healthy. The second died a few hours after delivery because of hydrops fetalis, likely due to HDFN; anti-Co(a) in the maternal serum, the father typed as Co(a+). The third pregnancy was followed up by the measurements of anti-Co(a) titre (additional antibodies were excluded), its functional activity by the chemiluminescence test (CLT) and the Doppler flow in the middle cerebral artery of the foetus...
February 2008: Transfusion Medicine
Anna Hildenbrand, Luther Lalitkumar, Soren Nielsen, Kristina Gemzell-Danielsson, Anneli Stavreus-Evers
OBJECTIVE: To study the expression of aquaporin-2 (AQP2) in human endometrium. DESIGN: Prospective clinical study. SETTING: Hospital-based unit for gynecology and obstetrics and research laboratories. PATIENT(S): Healthy women with proven fertility who were divided into four groups according to LH peak. INTERVENTION(S): Endometrial biopsies were obtained from 34 women on cycle days LH+4 to LH+14...
November 2006: Fertility and Sterility
Judy Anderson, Naoko Brown, Mala S Mahendroo, Jeff Reese
Biochemical changes of cervical connective tissue, including progressive disorganization of the collagen network and increased water content, occur during gestation to allow for cervical dilatation during labor, but the mechanisms that regulate cervical fluid balance are not fully understood. We examined whether aquaporins (AQPs), a family of membrane channel proteins that facilitate water transport, help mediate fluid balance in the mouse cervix during parturition. Of the 13 known murine AQPs, AQP0-2, 6, 7, 9, 11, and 12 were absent or at the limits of detection...
January 2006: Endocrinology
A Damiano, E Zotta, J Goldstein, I Reisin, C Ibarra
The syncytiotrophoblast of human term placenta (HST) is a continuous, multinucleated structure with minimal tight junctions, which results from the fusion of the underlying cytotrophoblast cells. Consequently, the transport of metabolites, ions and water from mother to fetus could take place primarily via transcellular routes. Transcellular water flux may be facilitated by aquaporins, membrane proteins functioning as water channels that are widely expressed in cells and tissues. Here, we report the presence of AQP3 and AQP9 in the apical membranes of HST using RT-PCR, immunoblotting and immunohistochemistry...
September 2001: Placenta
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