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Vasopressin obstetrics

S Subedi, M Chhetry, S Lamichhane
INTRODUCTION: Uterine myomas are the most common benign tumors of the female reproductive tract with myomectomy being one of the major modalities of the treatment in our set up. The aim of this study was to share the experiences of open myomectomy from a Teaching Hospital. METHODS: A observational study was conducted from a records of myomectomy cases in the department of Obstetrics and Gynaecology at Nobel Medical College teaching Hospital from June 2014- May 2016...
April 2016: JNMA; Journal of the Nepal Medical Association
Karolina Gruca-Stryjak, Mariola Ropacka-Lesiak, Grzegorz Breborowicz
This paper presents a case of a pregnant woman with a history of two cesarean sections. The patient was admitted to the hospital because of vaginal bleeding. The ultrasound revealed a placenta covering the internal os. The placenta was characterized by heterogeneous echogenicity with visible irregular hypoechogenic areas and blurred border between the placenta and the cervix. Rich vascularity was observed on the border of the placenta, urethra and the urinary bladder. Cystoscopy showed severe congestion around the urethra...
December 2015: Ginekologia Polska
Evan S Smith, Rajiv B Gala
BACKGROUND: Cesarean scar ectopic pregnancies are rare, with an incidence of approximately 1 in 2,000 pregnancies. The trauma of a cesarean section and a subsequent cesarean scar pregnancy can lead to the formation of an arteriovenous malformation (AVM). The resulting intractable bleeding is difficult to manage and can result in an emergent surgical intervention that could jeopardize a female's ability to become pregnant in the future. CASE REPORT: A 29-year-old female, gravida 2 para 1, with 1 prior low transverse cesarean section had a presumed cervical ectopic pregnancy treated with intramuscular methotrexate...
2015: Ochsner Journal
Abdullah Tuten, Mahmut Oncul, Mine Kucur, Metehan Imamoglu, Ozlem Balcı Ekmekci, Abdullah Serdar Acıkgoz, Fatma Selcen Cebe, Cengiz Yesilbas, Rıza Madazlı
OBJECTIVE: Early-onset pre-eclampsia is primarily associated with placental dysfunction, whereas late-onset pre-eclampsia is defined as a maternal constitutional disorder. As a protein cosynthesized with vasopressin, copeptin is a potential marker of metabolic syndrome and insulin resistance, which shares similar risk factors with pre-eclampsia. The aim of this study was to investigate the copeptin levels in patients with early-onset and late-onset pre-eclampsia. MATERIALS AND METHODS: A total of 80 pregnant women receiving antenatal and obstetric care were recruited...
August 2015: Taiwanese Journal of Obstetrics & Gynecology
Mark Santillan, Donna Santillan, Sabrina Scroggins, Jeremy Sandgren, Nicole Pearson, Katherine Gibson-Corley, Justin Grobe
OBJECTIVES: The objective of this study is to determine if chronic infusion of arginine vasopressin (AVP) during mouse pregnancy recapitulates the human phenotypes of preeclampsia. We hypothesize a causative role of elevated AVP in the pathogenesis of preeclampsia. METHODS: Wildtype C57Bl/6J females were chronically infused with AVP (24ng/h, s.c., or saline vehicle) before syngeneic mating. Systolic blood pressure during pregnancy was measured by tail-cuff plethysmography...
January 2015: Pregnancy Hypertension
Cinthia Elizabeth López-Ramírez, Jaqueline Arámbula-Almanza, Eva Elizabet Camarena-Pulido
BACKGROUND. Oxytocin is a well known drug most commonly used in obstetrics for induction or augmentation of labor. Due to its essential role in labor, and the overall effect in the body, oxytocin must be deeply understood by all obstetricians who use it and prescribe it. There is relevant data listed about oxytocin and has reviewed the evidence in 31 full text articles of indexed journals between 1999 and 2013. In search engines like MEDLINE, MedicLatina, PUBMED, Wolters Kluwer Healt, with keywords like: oxytocin, oxytocin receptor, oxytocin vasopressin, oxytocin postpartum, oxytocin review, oxytocin labor, oxytocin release...
July 2014: Ginecología y Obstetricia de México
Sven Wellmann, Jörg Benzing, Silvia Fleischlin, Nils Morgenthaler, Sotirios Fouzas, Christoph A Bührer, Gabor Szinnai, Tilo Burkhardt, Olav Lapaire
INTRODUCTION: To investigate the ability of cardiovascular plasma biomarkers to identify imminent preeclampsia (PE) among pregnant women at triage. MATERIAL AND METHODS: C-terminal pro-arginine vasopressin (copeptin), C-terminal pro-endothelin-1 (CT-proET-1), mid-regional pro-adrenomedullin (MR-proADM), and mid-regional pro-atrial natriuretic peptide (MR-proANP) were prospectively measured in pregnant women presenting at the obstetrical triage units of the University Hospitals of Basel and Zurich, Switzerland...
2014: Fetal Diagnosis and Therapy
Cornelia Bachmann, Harald Abele, Diethelm Wallwiener, Karl Oliver Kagan
INTRODUCTION: Challenges of modern medicine are peripartum bleeding complications as one of the most frequent cases of emergency in obstetrics with a prevalence of 0.5-5.0 %, meaning the main cause of maternal morbidity and mortality. In this context, inherited diseases such as Hermansky-Pudlak syndrome (HPS) should be recognized. HPS is a rare disease and belongs to a heterogeneous group of autosomal recessive disorders characterized by the triad of partial oculocutaneous albinism, disorder of "ceroid" metabolism and platelet storage pool deficiency with bleeding disorder...
June 2014: Archives of Gynecology and Obstetrics
K Kontoangelos, C C Papageorgiou, A E Raptis, A D Rabavilas, G N Papadimitriou
Oxytocin (OXT) is a neurohypophysial hormone which is synthesized in the paraventricular and supraoptic nuclei of the hypothalamus. OXT is currently attracting considerable attention because it has been discovered that it regulates various functions of behavior especially in the context of social interactions. OXT is a key component in bone formation, glycemia, male sexuality, cardiac differentiation and pregnancy and thus it is important to be further explored. The authors review various aspects of gestational diabetes, including definition, screening, diagnostic procedures, complications, clinical evaluation, indications of delivery and neonatal aspects...
November 2013: Current Diabetes Reviews
Shigehiko Mizutani, Taihei Tsunemi, Eita Mizutani, Akira Hattori, Masafumi Tsujimoto, Hiroshi Kobayashi
INTRODUCTION: Evidence elucidating the pathophysiology and pharmacology of conventional drugs, β-2 stimulants and magnesium sulfate, on safety and effectiveness for preeclampsia and preterm labor are rarely found. Both compounds pass through the placental barrier and could exert their adverse effects on the fetus. Exposure to these agents could be problematic long after the birth, and possibly result in diseases such as autism and cardiomyopathy. Since 1970 the possible roles of placental aminopeptidases, which degrade peptide hormones, in preeclampsia and preterm labor have been studied...
November 2013: Expert Opinion on Investigational Drugs
Miranda Harris-Glocker, Loralei L Thornburg, Eva K Pressman
BACKGROUND: Hermansky-Pudlak syndrome (HPS), a rare autosomal-recessive disorder encompassing multiple organs, is characterized by oculocutaneous albinism, platelet storage pool deficiency resulting in bleeding diathesis, and ceroid lipofuscin deposition which can lead to pulmonary fibrosis, colitis, cardiomyopathy and renal failure. Pregnancy in a patient with HPS can produce multiple complications such as peripartum hemorrhage and difficulties with administration of anesthesia, either regional or general...
May 2013: Journal of Reproductive Medicine
J-V Schaal, A Jarrassier, J Renner, A Salvadori, C Pelletier, T Villevieille
The authors report the performance of a labour epidural analgesia in a 26-year-old parturient presenting a moderate factor XI (FXI) deficiency. If haemostasis disorders usually contraindicate an epidural analgesia (with a risk of epidural haematoma), a moderate FXI deficiency is not an absolute contraindication to perform such an epidural analgesia. Desmopressin, sometimes used in surgery to reduce the bleeding, was administered to withdraw the catheter in better haemostasis conditions. No neurological signs were observed...
June 2013: Annales Françaises D'anesthèsie et de Rèanimation
Laxminarayan Karanth, Ankur Barua, Sachchithanantham Kanagasabai, N S Nair
BACKGROUND: Congenital bleeding disorders can cause obstetric haemorrhage during pregnancy, labour and following delivery. Desmopressin acetate is found to be an effective drug which can reduce the risk of haemorrhage and can also stop bleeding in certain congenital bleeding disorders. Its use in pregnancy has been controversial. Hence beneficial and adverse effects of desmopressin acetate in these groups of pregnant women should be evaluated. OBJECTIVES: To determine the efficacy of desmopressin acetate in preventing and treating acute bleeds during pregnancy in women with congenital bleeding disorders...
2013: Cochrane Database of Systematic Reviews
Shigehiko Mizutani, Katsuhiko Naruse, Akira Hattori, Masafumi Tsujimoto, Hiroshi Kobayashi
BACKGROUND: Both preeclampsia and preterm delivery are important complications in pregnancy and are still diseases of unknown causes, despite considerable research in recent times. These complications constitute obstetric emergencies that require expert knowledge and management skills. OBJECTIVES: This article reviews the emerging role of aminopeptidases in the monitoring and development of improved therapeutic strategies that provide better patient selection for therapeutic personalization...
September 2009: Expert Opinion on Medical Diagnostics
Ming-Jun Shao, Mei-Xu Hu, Min Hu
STUDY OBJECTIVE: To describe temporary bilateral uterine artery occlusion with titanium clips in combination with vasopressin as an effective surgical intervention to control hemorrhage during laparoscopic management of cesarean scar pregnancies (CSPs). DESIGN: Retrospective study (Canadian Task Force classification III). SETTING: University hospital in an obstetrics and gynecology department. INTERVENTIONS: Five patients with CSPs underwent removal of gestational ectopic masses via laparoscopy...
March 2013: Journal of Minimally Invasive Gynecology
M De Mesmay, A Rigouzzo, T Bui, N Louvet, I Constant
Gestational diabetes insipidus is an uncommon clinical disease whose prevalence is approximately two to three pregnancies per 100,000. It may be isolated or associated with preeclampsia. We report a case of gestational diabetes insipidus in a twin pregnancy, originally isolated during two months, and secondarily complicated by HELLP-syndrome. We recall the specific pathophysiology of polyuric-polydipsic syndrome during pregnancy and summarize its various causes. Finally, we discuss the indications, in case of isolated gestational diabetes insipidus, of treatment by dDAVP...
February 2013: Annales Françaises D'anesthèsie et de Rèanimation
V R Byams, P A Kouides, R Kulkarni, J R Baker, D L Brown, J C Gill, A M Grant, A H James, B A Konkle, J Maahs, M M Dumas, S McAlister, D Nance, D Nugent, C S Philipp, J M Soucie, E Stang
Inherited bleeding disorders are especially problematic for affected girls and women due to the monthly occurrence of menstrual periods and the effects on reproductive health. Although heavy menstrual bleeding (HMB) is the most common manifestation, females with inherited bleeding disorders (FBD) experience other bleeding symptoms throughout the lifespan that can lead to increased morbidity and impairment of daily activities. The purpose of this article is to describe the utility of a female-focused surveillance effort [female Universal Data Collection (UDC) project] in the United States Haemophilia Treatment Centres (HTCs) and to describe the baseline frequency and spectrum of diagnoses and outcomes...
July 2011: Haemophilia: the Official Journal of the World Federation of Hemophilia
Luregn J Schlapbach, Stefanie Frey, Susanna Bigler, Chiem Manh-Nhi, Christoph Aebi, Mathias Nelle, Jean-Marc Nuoffer
BACKGROUND: Vasopressin is one of the most important physiological stress and shock hormones. Copeptin, a stable vasopressin precursor, is a promising sepsis marker in adults. In contrast, its involvement in neonatal diseases remains unknown. The aim of this study was to establish copeptin concentrations in neonates of different stress states such as sepsis, chorioamnionitis and asphyxia. METHODS: Copeptin cord blood concentration was determined using the BRAHMS kryptor assay...
2011: BMC Pediatrics
Fu-Nan Cho, Cheng-Bin Liu, Ju-Yueh Li, San-Nung Chen
We report a case of timely diagnosis of placenta increta by sonography during the third stage of labor, which avoided any attempt at manual removal of a retained placenta and thus prevented additional postpartum bleeding. The use of intra-cervical injection of vasopressin and methotrexate and application of transcatheter arterial embolization of bilateral uterine arteries and right internal iliac arteries resulted in a good outcome.
July 2011: Journal of Clinical Ultrasound: JCU
Ebru Zulfikaroglu, Mine Islimye, Esra Aysin Tonguc, Ahmet Payasli, Ferruh Isman, Turgut Var, Nuri Danisman
AIMS: Increasing evidence supports the participation of metabolic syndrome and insulin resistance in the pathogenesis of pre-eclampsia. Copeptin is co-synthesized with vasopressin and is a new and promising novel marker of metabolic syndrome and insulin resistance. Our aim was to investigate copeptin levels in normotensive pregnant, mild and severe pre-eclamptic women. MATERIALS AND METHODS: We included 96 pregnant women who received antenatal and obstetric care at the perinatology clinic of our hospital...
September 2011: Journal of Obstetrics and Gynaecology Research
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