Valeria Cristina Sandrim, Marcelo Rizzatti Luizon, Eliane Pilan, Mayara Caldeira-Dias, Fernanda Borchers Coeli-Lacchini, Georgia Kors, Iuly Berndt, Riccardo Lacchini, Ricardo Carvalho Cavalli
OBJECTIVE: We examined the interaction of polymorphisms in the genes heme oxygenase-1 ( HMOX1 ) and nitric oxide synthase ( NOS3 ) in patients with preeclampsia (PE) as well as the responsiveness to methyldopa and to total antihypertensive therapy. METHODS: The genes HMOX1 (rs2071746, A/T) and NOS3 (rs1799983, G/T) were genotyped using TaqMan allele discrimination assays (Applied Biosystems, Foster City, CA, USA ), and the levels of enzyme heme oxygenase-1 ( HO-1) were measured using enzyme-linked immunosorbent assay (ELISA)...
June 19, 2020: Revista Brasileira de Ginecologia e Obstetrícia