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Hmox preeclampsia

Azusa Shinjo, Walter Ventura, Keiko Koide, Kyouko Hori, Junko Yotsumoto, Ryu Matsuoka, Kiyotake Ichizuka, Akihiko Sekizawa
OBJECTIVE: Maternal cigarette smoking is paradoxically associated with a decreased risk of developing preeclampsia. Since preeclampsia is thought to be associated with altered mechanisms of angiogenesis and oxidative stress, we aim to investigate the influence of maternal smoking on the early placental expression of a panel of genes related to angiogenesis and oxidative stress. MATERIAL AND METHODS: We collected villous tissue samples at 6-7 and 10-11 weeks of gestation from 31 women requesting surgical termination...
2014: Fetal Diagnosis and Therapy
Wenda Ramma, Asif Ahmed
Heme oxygenase (Hmox) is an endogenous system that offers protection against placental cytotoxic damage associated with preeclampsia. The Hmox1/carbon monoxide (CO) pathway inhibits soluble Flt-1 (sFlt-1) and soluble Endoglin (sEng). More importantly, statins induce Hmox1 and suppress the release of sFlt-1 and sEng; thus, statins and Hmox1 activators are potential novel therapeutic agents for treating preeclampsia. The contribution of the Hmox system to the pathogenesis of preeclampsia has been further indicated by the incidence of preeclampsia being reduced by a third in smokers, who had reduced levels of circulating sFlt-1...
March 2014: Journal of Reproductive Immunology
M L Martinez-Fierro, I Garza-Veloz, K Carrillo-Sanchez, V Martinez-Gaytan, R Cortes-Flores, M A Ochoa-Torres, G G Guerrero, I P Rodriguez-Sanchez, C O Cancela-Murrieta, M Zamudio-Osuna, J I Badillo-Almaraz, C Castruita-De la Rosa
OBJECTIVE: To evaluate the peripheral blood mononuclear cell (PBMC) expression levels of hemeoxygenase 1 (HMOX-1), superoxide dismutase 1 (SOD-1), vascular endothelial growth factor A (VEGF-A), transforming growth factor beta 1 (TGF-β1), interleukin (IL)-6, IL-15 and AdipoQ genes to study their association with preeclampsia (PE). METHODS: A total of 177 pregnant women were recruited: 108 cases and 69 controls. Quantification of gene expression was measured by quantitative real-time polymerase chain reaction (PCR) using TaqMan probes...
May 2014: Hypertension in Pregnancy
Hui Zhao, Junya Azuma, Flora Kalish, Ronald J Wong, David K Stevenson
The placental vasculature is critical for nutrient, gas, and waste exchange between the maternal and fetal systems. Its development depends on the proper expression and interaction of angiogenesis and associated growth factors. Heme oxygenase (HMOX), the enzyme for heme degradation, plays a role in angiogenesis and is highly expressed in the placenta. To evaluate the role of maternal HMOX1, the inducible HMOX isozyme, on placental vasculature formation, mice with a partial deficiency in Hmox1 (Hmox1(+/-)) were used...
November 2011: Biology of Reproduction
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