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glioma and lncRNA

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https://www.readbyqxmd.com/read/29464001/piwil3-oip5-as1-mir-367-3p-cebpa-feedback-loop-regulates-the-biological-behavior-of-glioma-cells
#1
Xiaobai Liu, Jian Zheng, Yixue Xue, Hai Yu, Wei Gong, Ping Wang, Zhen Li, Yunhui Liu
Rationale: PIWI-interacting RNAs (piRNAs), a class of newly discovered small RNA molecules that function by binding to the Argonaute protein family (i.e., the PIWIL protein subfamily), and long noncoding RNAs (lncRNA) are implicated in several cancers. However, the detailed roles of ncRNAs in glioma remain unclear. Methods: The expression of PIWIL3, piR-30188, OIP5-AS1, miR-367, CEBPA and TRAF4 were measured in glioma tissues and cells. The role of PIWIL3/OIP5-AS1/miR-367-3p/CEBPA feedback loop was evaluated in cell and animal models...
2018: Theranostics
https://www.readbyqxmd.com/read/29458374/new-insights-into-long-noncoding-rnas-and-their-roles-in-glioma
#2
REVIEW
Zixuan Peng, Changhong Liu, Minghua Wu
Glioma is one of the most prevalent types of primary intracranial carcinoma with varying malignancy grades I-IV and histological subtypes, including astrocytomas, glioblastoma multiform (GBM), oligodendrogliomas and mixed tumors. Glioma is characterized by rapid cell proliferation and angiogenesis, and the WHO grade IV glioblastoma, which is highly malignant with poor prognosis because GBM stem-like cells (GSCs) are resistant to conventional therapy and easily recrudescent, accounts for the majority of gliomas...
February 19, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29422115/long-non-coding-rna-h19-promotes-proliferation-and-invasion-in-human-glioma-cells-by-downregulating-mir-152
#3
Lei Chen, Yuhai Wang, Jianqing He, Chunlei Zhang, Junhui Chen, Dongliang Shi
MiR-152 and lncRNA H19 have been frequently implicated in various cellular process including cell proliferation, invasion, angiogenesis and apoptosis. However, the interaction between miR-152 and H19 in glioma has never been reported. qRT PCR was used to examine the expression of miR 152 and H19 in human glioma cell lines and normal human astrocytes (NHAs) cells The interaction between miR 152 and lncRNA H19 were assessed by dual luciferase reporter assay. MTT assay and transwell invasion assay were used to determine the proliferation and invasion of U251 and U87 cells...
February 8, 2018: Oncology Research
https://www.readbyqxmd.com/read/29421578/long-non-coding-rna-enst01108-promotes-carcinogenesis-of-glioma-by-acting-as-a-molecular-sponge-to-modulate-mir-489
#4
Dawei Xu, Ruihua Liu, Lei Meng, Yi Zhang, Guangjian Lu, Pengju Ma
Gliomas are the most common primary malignant tumor in the adult central nervous system with poor prognosis. Exploring novel biomarkers and elucidating underlying molecular mechanisms to provide effective therapeutic methods is in an urgent need. Long noncoding RNAs (lncRNAs) is involved in various human diseases including cancer. However, studies on lncRNAs and gliomas are limited. In this study, we explored the expression patterns of lncRNAs in 4 pairs of glioma samples and adjacent normal tissues via microarray and chose the most up-regulated lncRNA ENST01108 (ENST01108) to further verify its oncogenic role in glioma...
February 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29412778/the-long-noncoding-rna-tp73-as1-interacted-with-mir-124-to-modulate-glioma-growth-by-targeting-inhibitor-of-apoptosis-stimulating-protein-of-p53
#5
Shuai Xiao, Rensheng Wang, Xiangwei Wu, Wen Liu, Shanshan Ma
P73 antisense RNA 1T (non-protein coding), known as TP73-AS1 or PDAM, is a long noncoding RNA (lncRNA), which may regulate apoptosis by regulation of p53-dependent antiapoptotic genes. An abnormal change of TP73-AS1 expression was noticed in cancers. The effects of TP73-AS1 in brain glioma growth and the underlying mechanism remain unclear so far. In this study, the effect of TP73-AS1 in human brain glioma cell lines and clinical tumor samples was detected so as to reveal its role and function. In this study, TP73-AS1 was specifically upregulated in brain glioma cell lines and promoted glioma cell growth through targeting miR-124...
February 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29391808/the-silencing-of-lncrna-h19-decreases-chemoresistance-of-human-glioma-cells-to-temozolomide-by-suppressing-epithelial-mesenchymal-transition-via-the-wnt-%C3%AE-catenin-pathway
#6
Linwei Jia, Yaohui Tian, Yonghan Chen, Gang Zhang
Introduction: Temozolomide (TMZ) is commonly used for glioma chemotherapy. However, TMZ resistance limits the therapeutic effect of TMZ in glioma treatment. LncRNA-H19 acts as an oncogenic LncRNA in some types of cancers and has been reported to be up-regulated in glioma. Materials and methods: In our present study, we established TMZ-resistant glioma cells (U-251TMZ and M059JTMZ) to explore the effect of H19 on the chemoresistance of glioma cells. Results: We observed that the expression of H19 was significantly increased in U-251TMZ and M059JTMZ cells...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29341117/hoxd-as1-mir-130a-sponge-regulates-glioma-development-by-targeting-e2f8
#7
Yinan Chen, Fengbo Zhao, Daming Cui, Rui Jiang, Jian Chen, Qingfeng Huang, Jinlong Shi
Glioma development is an extremely complex process with changes occurring in numerous genes. HOXD antisense growth-associated long non-coding RNA (HOXD-AS1), an important long non-coding RNA (lncRNA), is known to regulate metastasis-related gene expression in bladder cancer, ovarian cancer and neuroblastoma. Here, we elucidated the function and possible molecular mechanisms of lncRNA HOXD-AS1 in human glioma cells. Our results proved that HOXD-AS1 expression was upregulated in glioma tissues and in glioma cell lines...
January 17, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29319172/long-non-coding-rna-hotair-acts-as-a-competing-endogenous-rna-to-promote-glioma-progression-by-sponging-mir-126-5p
#8
Liang Liu, Sitong Cui, Teng Wan, Xiaojian Li, Wei Tian, Rui Zhang, Liangsheng Luo, Yan Shi
LncRNA HOX transcript antisense intergenic RNA (HOTAIR) has been shown to play prominent roles in tumorigenesis. However, its precise molecular mechanism in glioma has not been completely elucidated. In this study, we found that HOTAIR was aberrantly up-regulated in glioma tissues and was negatively correlated with miR-126-5p expression. Next, we determined that HOTAIR promote glioma progression by sponging miR-126-5p. Subsequently, glutaminase (GLS) was confirmed to be a direct target of miR-126-5p using bioinformatics software and a luciferase reporter assay...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29314442/lncrna-cdkn2bas-rs2157719-genetic-variant-contributes-to-medulloblastoma-predisposition
#9
Yi-Dong Chen, Nasha Zhang, Xiao-Guang Qiu, Jupeng Yuan, Ming Yang
BACKGROUND: How germline single nucleotide polymorphisms are involved in the etiology of medulloblastoma remans poorly understood. We hypothesized that CCDKN2A/B rs1063192 and rs4977756 and also the long noncoding RNA (lncRNA) CDKN2BAS rs2157719 glioma susceptibility polymorphisms identified by genome-wide association studies may contribute to medulloblastoma predisposition. METHODS: To test this hypothesis, we genotyped these genetic variants among 160 medulloblastoma patients and 443 health controls in a Chinese population...
January 4, 2018: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29301870/lncrna-dancr%C3%A2-functions-as-a-competing-endogenous-rna-to-regulate-rab1a%C3%A2-expression-by-sponging%C3%A2-mir-634%C3%A2-in-glioma
#10
Dawei Xu, Jian Yu, Guojun Gao, Guangjian Lu, Yi Zhang, Pengju Ma
Long non-coding RNA (lncRNA) differentiation antagonizing nonprotein coding RNA (DANCR) play important regulatory roles in many solid tumors. However, the effect of DANCR in glioma progression and underlying molecular mechanisms were not entirely explored. In the present study, we determined the expression of DANCR in glioma tissues and cell lines using qRT-PCR and further defined the biological functions. Furthermore, we used luciferase reporter assay, western blot, and RNA immunoprecipitation (RIP) to explore the underlying mechanism...
January 4, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29218099/long-non-coding-rna-hotair-enhances-angiogenesis-by-induction-of-vegfa-expression-in-glioma-cells-and-transmission-to-endothelial-cells-via-glioma-cell-derived-extracellular-vesicles
#11
Xin Ma, Zhaohui Li, Ting Li, Linwensi Zhu, Zhenshengnan Li, Nan Tian
Gliomas are one the most prevalent malignant carcinomas of the central nervous system, and angiogenesis plays a critical role in the progression of these blood vessel-rich tumors. HOTAIR, a long non-coding RNA (lncRNA), acts as an oncogene in gliomas; however, its role in glioma angiogenesis remains unclear. In the present study, we identified a pro-angiogenic activity of HOTAIR. Silencing HOTAIR inhibited glioma-induced endothelial cell proliferation, migration, and tube formation. Further studies showed that vascular endothelial growth factor A (VEGFA) was involved in the HOTAIR-induced glioma angiogenesis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29187887/long-non-coding-rna-xist-promotes-glioma-tumorigenicity-and-angiogenesis-by-acting-as-a-molecular-sponge-of-mir-429
#12
Zhihua Cheng, Zhenshengnan Li, Ke Ma, Xiaoyu Li, Nan Tian, Jinyue Duan, Xu Xiao, Yi Wang
Glioma is a worldwide malignancy, which displays significantly active metastasis and angiogenesis. Interaction between long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) has been shown to play crucial role in regulating tumor properties. However, the potential of lncRNA X-inactive specific transcript (XIST) to function as a miRNA regulator and its relevance in glioma tumorigenicity and angiogenesis have so far remained unclear. Expression analysis of lncRNA XIST in glioma cells revealed its significant up-regulation...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29181061/up-regulation-of-the-long-non-coding-rna-rmrp-contributes-to-glioma-progression-and-promotes-glioma-cell-proliferation-and-invasion
#13
Wenxian Feng, Li Li, Xuchang Xu, Yunqi Jiao, Wei Du
Introduction: Gliomas are the most common malignant tumors of the brain. Long non-coding RNAs (lncRNAs) play key regulatory roles in various tumors. In this study, we aimed to determine the expression and biological roles of lncRNA RMRP in glioma. Material and methods: The relative expression level of lncRNA RMRP was determined by quantitative real-time polymerase chain reaction (qRT-PCR) in a total of 39 patients with glioma. RNA interference (RNAi) approaches were used to investigate the biological functions of RMRP...
October 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29170907/an-immune-related-lncrna-signature-for-patients-with-anaplastic-gliomas
#14
Wen Wang, Zheng Zhao, Fan Yang, Haoyuan Wang, Fan Wu, Tingyu Liang, Xiaoyan Yan, Jiye Li, Qing Lan, Jiangfei Wang, Jizong Zhao
We investigated immune-related long non-coding RNAs (lncRNAs) that may be exploited as potential therapeutic targets in anaplastic gliomas. We obtained 572 lncRNAs and 317 immune genes from the Chinese Glioma Genome Atlas microarray and constructed immune-related lncRNAs co-expression networks to identify immune-related lncRNAs. Two additional datasets (GSE16011, REMBRANDT) were used for validation. Gene set enrichment analysis and principal component analysis were used for functional annotation. Immune-lncRNAs co-expression networks were constructed...
November 23, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29152149/the-long-non-coding-rna-crnde-acts-as-a-cerna-and-promotes-glioma-malignancy-by-preventing-mir-136-5p-mediated-downregulation-of-bcl-2-and-wnt2
#15
Dong-Xue Li, Xiao-Rui Fei, Yong-Fei Dong, Chuan-Dong Cheng, Yang Yang, Xue-Fei Deng, Hai-Liang Huang, Wan-Xiang Niu, Chen-Xu Zhou, Cheng-Yu Xia, Chao-Shi Niu
The colorectal neoplasia differentially expressed (CRNDE) gene encodes a long non-coding RNA (lncRNA) that is the most unregulated among 129 lncRNAs differentially expressed in gliomas. In this study, we confirmed high CRNDE expression in clinical glioma specimens and observed through experiments in human glioma cell lines a novel molecular mechanism by which CRNDE may contribute to glioma pathogenesis. By inducing or silencing CRNDE expression, we detected a positive correlation between CRNDE levels and the proliferative, migratory, and invasive capacities of glioma cells, which were concomitant with a decreased apoptosis rate...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29138748/identifying-novel-glioma-associated-noncoding-rnas-by-their-expression-profiles
#16
Alenka Matjašič, Mojca Tajnik, Emanuela Boštjančič, Mara Popović, Boštjan Matos, Damjan Glavač
Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) play a significant role in cancer development as regulators of protein-coding genes. Their dysregulation was in some extent already associated with glioma, the most aggressive primary brain tumours in adults. The correct diagnosis and treatment selection due to high tumour heterogeneity might be difficult and inadequate, resulting in poor prognosis. Studies of expression patterns of noncoding RNAs (ncRNAs) could provide useful insight in glioma molecular development...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/29136760/upregulation-of-casc2-sensitized-glioma-to-temozolomide-cytotoxicity-through-autophagy-inhibition-by-sponging-mir-193a-5p-and-regulating-mtor-expression
#17
Chunming Jiang, Fang Shen, Jianmin Du, Xiang Fang, Xiaoli Li, Jin Su, Xiaohua Wang, Xianmei Huang, Zhangli Liu
OBJECTIVE: Numerous studies suggested autophagy was involved in temozolomide (TMZ) resistance in glioma. Long non-coding RNA (lncRNA) CASC2 was shown to be downregulated in glioma tissues and cell lines, and was related to the TMZ resistance. However, whether CASC2 affects TMZ resistance through regulating autophagy is unknown. The aim of this study was to assess the role and mechanism of CASC2 in TMZ-induced drug resistance in glioma cells. METHODS: Glioma and the adjacent non-cancerous tissues from 32 patients were collected...
November 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29132362/knockdown-of-sox2ot-inhibits-the-malignant-biological-behaviors-of-glioblastoma-stem-cells-via-up-regulating-the-expression-of-mir-194-5p-and-mir-122
#18
Rui Su, Shuo Cao, Jun Ma, Yunhui Liu, Xiaobai Liu, Jian Zheng, Jiajia Chen, Libo Liu, Heng Cai, Zhen Li, Lini Zhao, Qianru He, Yixue Xue
BACKGROUND: Accumulating evidence has highlighted the potential role of long non-coding RNAs (lncRNAs) in the biological behaviors of glioblastoma stem cells (GSCs). Here, we elucidated the function and possible molecular mechanisms of the effect of lncRNA-SOX2OT on the biological behaviors of GSCs. RESULTS: Real-time PCR demonstrated that SOX2OT expression was up-regulated in glioma tissues and GSCs. Knockdown of SOX2OT inhibited the proliferation, migration and invasion of GSCs, and promoted GSCs apoptosis...
November 13, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/29113674/lncrna-zeb1-as1-predicts-unfavorable-prognosis-in-gastric-cancer
#19
Yanliang Li, Xiaowen Wen, Longgang Wang, Xianjun Sun, Heng Ma, Zheng Fu, Leping Li
OBJECTIVES: LncRNA ZEB1 Antisense 1 (ZEB1-AS1) has been suggested to be an oncogenic role in human hepatocellular carcinoma, osteosarcoma, glioma and esophageal carcinoma progression. However, the clinical significance and biological function of ZEB1-AS1 in gastric cancer is poorly understood. METHODS: Levels of ZEB1-AS1 expression in gastric cancer tissues and cell lines were detected by qRT-PCR. Loss-of-function and gain-of-function studies were conducted to explore the biological function of ZEB1-AS1 in gastric cancer cells migration, invasion and EMT process...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29089067/knockdown-of-long-non-coding-rna-lucat1-inhibits-cell-viability-and-invasion-by-regulating-mir-375-in-glioma
#20
Yan-Sheng Gao, Xian-Zhi Liu, Yong-Gang Zhang, Xian-Jin Liu, Ling-Zhen Li
Recently, long non-coding RNAs (lncRNAs) have emerged as new gene regulators and prognostic markers in several cancers,including glioma. Here, we focused on lncRNA LUCAT1 on the progression of glioma. QRT-PCR was used to determine the expression of LUCAT1 and miR-375 in glioma tissues and cells. MTT and transwell invasion assays were performed to determine the function of LUCAT1 in glioma progression. Bioinformatics tool DIANA was used to predict the targets of LUCAT1. Pearson's correlation analysis was performed to explore the correlation between LUCAT1 and miR-375...
October 24, 2017: Oncology Research
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