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glioma and lncRNA

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https://www.readbyqxmd.com/read/29685003/long-non-coding-rna-snhg16-contributes-to-glioma-malignancy-by-competitively-binding-mir-20a-5p-with-e2f1
#1
B Y Yang, Q Meng, Y Sun, L Gao, J X Yang
Glioma is among the most fatal and highly aggressive primary malignant tumors in the central nervous system. Small nucleolar RNA host gene 16 (SNHG16) is identified to play an oncogenic role in several cancers. However, the exact mechanism of SNHG16 action in the regulation of glioma development remains unknown. LncRNA SNHG16 was increased in glioma tissues and cells compared with normal brain tissues and cells. SNHG16 expression was correlated with the malignancy and poor prognosis of glioma patients. SNHG16 and E2F1 contained a binding site of miR-20a-5p...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29669323/long-intergenic-noncoding-rna-00152-promotes-glioma-cell-proliferation-and-invasion-by-interacting-with-mir-16
#2
Xin Chen, Deheng Li, Yang Gao, Wei Tang, Lao Iw, Yiqun Cao, Bin Hao
BACKGROUND/AIMS: Long noncoding RNAs (lncRNAs) are a novel class of protein-noncoding transcripts that are aberrantly expressed in multiple diseases including cancers. LINC00152 has been identified as an oncogene involved in many kinds of cancer; however, its expression pattern and function in human glioma remain unclear. METHODS: Quantitative real-time polymerase chain reaction was carried out to measure LINC00152 expression in human glioma cell lines and tissues...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29655792/long-non-coding-rna-uca1-mir-182-pfkfb2-axis-modulates-glioblastoma-associated-stromal-cells-mediated-glycolysis-and-invasion-of-glioma-cells
#3
Zongze He, Chao You, Dongdong Zhao
Glioblastoma (GB) is the most common and deadliest malignant primary brain tumor with a high recurrence. In this study, lncRNA UCA1/miR-182 axis has been regarded as a nodal driver of glioma invasion mediated by GB-associated stromal cells (GASCs) and GASC-secreted chemokine CXCL14. In clinical specimens, CXCL14 upregulation in GASCs also correlated with poor prognosis. Notably, CXCL14-high GASCs mediated lncRNA UCA1 upregulation and miR-182 downregulation in glioma cells. Moreover, miR-182 directly bound to the fructose-2,6-biphosphatase PFKFB2; UCA1/miR-182 axis thereby modulated GASC-induced glycolysis in glioma cells...
April 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29653367/upregulation-of-lncrna-plncrna-1-indicates-the-poor-prognosis-and-promotes-glioma-progression-by-activation-of-notch-signal-pathway
#4
Xiaolong Wang, Yungang Yan, Chunman Zhang, Wei Wei, Xin Ai, Yongbin Pang, Ying Bian
Prostate cancer-up-regulated long noncoding RNA 1(PlncRNA-1) has been demonstrated to be increased in several cancers, which plays an oncogenic role in the development of cancer. However, the exact functions and molecular mechanism of PlncRNA-1 in the tumorigenesis of glioma has not been studied. In present work, we firstly identified that PlncRNA-1 expression levels were prominently augmented in glioma patient tissues and glioma cell lines compared with adjacent noncancerous tissue and normal cells, respectively...
April 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29644006/the-long-non-coding-rna-hotair-is-transcriptionally-activated-by-hoxa9-and-is-an-independent-prognostic-marker-in-patients-with-malignant-glioma
#5
Ana Xavier-Magalhães, Céline S Gonçalves, Anne Fogli, Tatiana Lourenço, Marta Pojo, Bruno Pereira, Miguel Rocha, Maria Celeste Lopes, Inês Crespo, Olinda Rebelo, Herminio Tão, João Lima, Ricardo Moreira, Afonso A Pinto, Chris Jones, Rui M Reis, Joseph F Costello, Philippe Arnaud, Nuno Sousa, Bruno M Costa
The lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary brain tumors, and its clinical relevance. HOTAIR gene expression, methylation, copy-number and prognostic value were investigated in human gliomas integrating data from online datasets and our cohorts. High levels of HOTAIR were associated with higher grades of glioma, particularly IDH wild-type cases. Mechanistically, HOTAIR was overexpressed in a gene dosage-independent manner, while DNA methylation levels of particular CpGs in HOTAIR locus were associated with HOTAIR expression levels in GBM clinical specimens and cell lines...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29620147/lncrna-pvt1-promotes-the-angiogenesis-of-vascular-endothelial-cell-by-targeting-mir%C3%A2-26b-to-activate-ctgf-angpt2
#6
Jifu Zheng, Lili Hu, Jing Cheng, Jing Xu, Zhiqiang Zhong, Yuan Yang, Zheng Yuan
Angiogenesis is essential for various biological processes, including tumor blood supply delivery, cancer cell growth, invasion and metastasis. Plasmacytoma variant translocation 1 (PVT1) long noncoding RNA (lncRNA) has been previously reported to affect angiogenesis of glioma microvascular endothelial cells by regulating microRNA (miR)‑186 expression level. However, the specific underlying molecular mechanism of PVT1 regulation of angiogenesis in vascular endothelial cells remains to be elucidated. The present study investigated the role of PVT1 in cell proliferation, migration and vascular tube formation of human umbilical vein endothelial cells (HUVECs) using MTT assay, Transwell migration assay and in vitro vascular tube formation assay, respectively...
March 29, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29615150/lncrna-bcar4-increases-viability-invasion-and-migration-non-small-cell-lung-cancer-cells-by-targeting-glioma-associated-oncogene-2-gli2
#7
Hongliang Yang, Lei Yan, Kai Sun, Xiaodong Sun, Xudong Zhang, Kerui Cai, Tiejun Song
OBJECTIVE: This study was aimed to explore the effects of lncRNA BCAR4 on the viability and aggressiveness of non-smallcell lung cancer (NSCLC) cells. METHODS: qRTPCR was used to determine the expression of lncRNA BCAR4 and GLI2 downstream genes in NSCLC tissues and cell lines. Chromatin isolation by RNA purification (CHIRP) and western blot were employed to measure the expression of GLI2 downstream proteins. Ki67 expression in nude mice tumors was tested by immunohistochemistry...
April 3, 2018: Oncology Research
https://www.readbyqxmd.com/read/29602127/overexpression-of-lncrna-dancr-positively-affects-progression-of-glioma-via-activating-wnt-%C3%AE-catenin-signaling
#8
Jun Li, Liang Zhou
Long non-coding RNA DANCR has been certified to act as an effective regulator in the tumorigenesis of several types of tumors. In this study, the special role of DANCR in glioma progression was explored. It was speculated that high expression of DANCR in glioma tissues and cells might be an oncogenic factor. To understand the correlation between the expression pattern of DANCR and the overall survival of glioma patients, the Kaplan Meier method was used for analysis. The result showed that high expression of DANCR might be a poor prognostic factor in glioma patients...
March 27, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29579705/lncrna-snhg6-acts-as-a-prognostic-factor-to-regulate-cell-proliferation-in-glioma-through-targeting-p21
#9
Gang Cai, Qing Zhu, Liqun Yuan, Qing Lan
It has been certified that long noncoding RNAs (lncRNAs) are crucial regulators in the progression of various human cancers. snoRNA host gene 6 (SNHG6) has been uncovered to affect the initial stage and tumorigenesis of hepatocellular carcinoma. Nevertheless, the expression pattern and biological role of SNHG6 in glioma still need to be investigated. The study aims to investigate the expression pattern, biological role and the potential mechanism of SNHG6 in glioma. In this study, the high expression of SNHG6 was tested in both glioma tissues and glioma cells...
March 23, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29572052/long-noncoding-rna-dancr-mediates-cisplatin-resistance-in-glioma-cells-via-activating-axl-pi3k-akt-nf-%C3%AE%C2%BAb-signaling-pathway
#10
Yangang Ma, Guanghua Zhou, Mengyou Li, Dianfeng Hu, Lianqun Zhang, Peng Liu, Kai Lin
Malignant glioma is an aggressive type of brain tumor with poor prognosis and mostly incurable. Although cisplatin is used for adjuvant chemotherapy against glioma, intrinsic and acquired resistance restricts the application of cisplatin. Long noncoding RNA (lncRNA) DANCR is reported to regulate the differentiation and progression of several cancers. However, whether DANCR participates in cisplatin resistance of glioma is still unknown. In this study, we found that DANCR expression was negatively correlated with cisplatin sensitivity in glioma cells...
March 20, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29564570/prognostic-and-clinicopathological-significance-of-long-non-coding-rna-in-glioma
#11
REVIEW
Junhong Li, Ruofei Liang, Chen Song, Yufan Xiang, Yanhui Liu
Growing evidence from recent studies have revealed that long non-coding RNA (lncRNA) might be a useful prognostic biomarker for glioma; we therefore conducted the current meta-analysis to evaluate prognostic and clinicopathological predictive value of lncRNA expression for glioma patients. Eligible studies were identified through multiple research strategies in PubMed, EMBASE, Web of Science, and Cochrane Library up to May 2017. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were utilized to calculate patient's survival...
March 21, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29541171/association-between-long-non-coding-rnas-expression-and-pathogenesis-and-progression-of-gliomas
#12
Jie Zhou, Wei Xiang, Shenjie Li, Qi Hu, Tao Peng, Ligang Chen, Yang Ming
The incidence rate of gliomas is the highest among primary brain tumors. Although the understanding of the molecular pathology of glioma has improved during the previous two decades, effective therapies are not yet available to treat these tumors. Previous studies have indicated that long non-coding RNAs (lncRNAs) have a close association with glioma, suggesting that lncRNAs may be potential targets for the development of novel treatments for glioma. The present review summarized the latest studies on the dysregulation of lncRNAs in glioma, and discussed their potential use in the diagnosis, prognosis and therapies of glioma...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29529599/lncrna-snhg16-functions-as-an-oncogene-by-sponging-mir-4518-and-up-regulating-prmt5-expression-in-glioma
#13
Ye-Fen Lu, Xue-Li Cai, Zheng-Zheng Li, Jing Lv, Yi-An Xiang, Jian-Jun Chen, Wei-Jing Chen, Wei-Yan Sun, Xiu-Mei Liu, Jian-Bo Chen
BACKGROUND/AIMS: Long noncoding RNAs (lncRNAs) have recently emerged as novel and potentially promising therapeutic targets in various cancers. However, the expression pattern and biological function of lncRNAs in glioma remain largely elusive. In the present study, we investigated the functional role of an lncRNA, small nucleolar RNA host gene 16 (SNHG16), in glioma. METHODS: The expression levels of SNHG16 and miR-4518 were measured using qRT-PCR. The relationship between the levels of SNHG16 and clinicopathologic features were statically analyzed...
March 6, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29501773/pvt1-regulates-the-malignant-behaviors-of-human-glioma-cells-by-targeting-mir-190a-5p-and-mir-488-3p
#14
Weishuang Xue, Jiajia Chen, Xiaobai Liu, Wei Gong, Jian Zheng, Xu Guo, Yunhui Liu, Libo Liu, Jun Ma, Ping Wang, Zhen Li, Yixue Xue
The long non-coding RNA (lncRNA) PVT1 is reported to be involved in tumorigenesis and the progression of many malignancies. However, the function of PVT1 in gliomas remains unclarified. The present study demonstrated the expression level of PVT1 using qRT-PCR. The role of PVT1 in the regulation of biological behaviors of glioma cells was investigated using CCK-8 assay, Transwell assay and flow cytometry. The possible molecular mechanisms were also elucidated. In our results, PVT1 was up-regulated in glioma specimens and cell lines...
March 1, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29499929/inhibition-of-tdp43-mediated-snhg12-mir-195-sox5-feedback-loop-impeded-malignant-biological-behaviors-of-glioma-cells
#15
Xiaobai Liu, Jian Zheng, Yixue Xue, Chengbin Qu, Jiajia Chen, Zhenhua Wang, Zhen Li, Lei Zhang, Yunhui Liu
Long non-coding RNA (lncRNA) dysregulation is involved in tumorigenesis and regulation of diverse cellular processes in gliomas. lncRNA SNHG12 is upregulated and promotes cell growth in human osteosarcoma cells. TAR-DNA binding protein 43 (TDP43) functions as an oncogene in various tumors by modulating RNA expression. Downregulation of TDP43 or SNHG12 significantly inhibited malignant biological behaviors of glioma cells. miR-195, downregulated in glioma tissues and cells, significantly impaired the malignant progression of glioma cells...
March 2, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29464001/piwil3-oip5-as1-mir-367-3p-cebpa-feedback-loop-regulates-the-biological-behavior-of-glioma-cells
#16
Xiaobai Liu, Jian Zheng, Yixue Xue, Hai Yu, Wei Gong, Ping Wang, Zhen Li, Yunhui Liu
Rationale: PIWI-interacting RNAs (piRNAs), a class of newly discovered small RNA molecules that function by binding to the Argonaute protein family (i.e., the PIWIL protein subfamily), and long noncoding RNAs (lncRNA) are implicated in several cancers. However, the detailed roles of ncRNAs in glioma remain unclear. Methods: The expression of PIWIL3, piR-30188, OIP5-AS1, miR-367, CEBPA and TRAF4 were measured in glioma tissues and cells. The role of PIWIL3/OIP5-AS1/miR-367-3p/CEBPA feedback loop was evaluated in cell and animal models...
2018: Theranostics
https://www.readbyqxmd.com/read/29458374/new-insights-into-long-noncoding-rnas-and-their-roles-in-glioma
#17
REVIEW
Zixuan Peng, Changhong Liu, Minghua Wu
Glioma is one of the most prevalent types of primary intracranial carcinoma with varying malignancy grades I-IV and histological subtypes, including astrocytomas, glioblastoma multiform (GBM), oligodendrogliomas and mixed tumors. Glioma is characterized by rapid cell proliferation and angiogenesis, and the WHO grade IV glioblastoma, which is highly malignant with poor prognosis because GBM stem-like cells (GSCs) are resistant to conventional therapy and easily recrudescent, accounts for the majority of gliomas...
February 19, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29422115/long-non-coding-rna-h19-promotes-proliferation-and-invasion-in-human-glioma-cells-by-downregulating-mir-152
#18
Lei Chen, Yuhai Wang, Jianqing He, Chunlei Zhang, Junhui Chen, Dongliang Shi
MiR-152 and lncRNA H19 have been frequently implicated in various cellular process including cell proliferation, invasion, angiogenesis and apoptosis. However, the interaction between miR-152 and H19 in glioma has never been reported. qRT PCR was used to examine the expression of miR 152 and H19 in human glioma cell lines and normal human astrocytes (NHAs) cells The interaction between miR 152 and lncRNA H19 were assessed by dual luciferase reporter assay. MTT assay and transwell invasion assay were used to determine the proliferation and invasion of U251 and U87 cells...
February 8, 2018: Oncology Research
https://www.readbyqxmd.com/read/29421578/long-non-coding-rna-enst01108-promotes-carcinogenesis-of-glioma-by-acting-as-a-molecular-sponge-to-modulate-mir-489
#19
Dawei Xu, Ruihua Liu, Lei Meng, Yi Zhang, Guangjian Lu, Pengju Ma
Gliomas are the most common primary malignant tumor in the adult central nervous system with poor prognosis. Exploring novel biomarkers and elucidating underlying molecular mechanisms to provide effective therapeutic methods is in an urgent need. Long noncoding RNAs (lncRNAs) is involved in various human diseases including cancer. However, studies on lncRNAs and gliomas are limited. In this study, we explored the expression patterns of lncRNAs in 4 pairs of glioma samples and adjacent normal tissues via microarray and chose the most up-regulated lncRNA ENST01108 (ENST01108) to further verify its oncogenic role in glioma...
February 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29412778/the-long-noncoding-rna-tp73-as1-interacted-with-mir-124-to-modulate-glioma-growth-by-targeting-inhibitor-of-apoptosis-stimulating-protein-of-p53
#20
Shuai Xiao, Rensheng Wang, Xiangwei Wu, Wen Liu, Shanshan Ma
P73 antisense RNA 1T (non-protein coding), known as TP73-AS1 or PDAM, is a long noncoding RNA (lncRNA), which may regulate apoptosis by regulation of p53-dependent antiapoptotic genes. An abnormal change of TP73-AS1 expression was noticed in cancers. The effects of TP73-AS1 in brain glioma growth and the underlying mechanism remain unclear so far. In this study, the effect of TP73-AS1 in human brain glioma cell lines and clinical tumor samples was detected so as to reveal its role and function. In this study, TP73-AS1 was specifically upregulated in brain glioma cell lines and promoted glioma cell growth through targeting miR-124...
February 2018: DNA and Cell Biology
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