keyword
MENU ▼
Read by QxMD icon Read
search

Nora volkow

keyword
https://www.readbyqxmd.com/read/28466758/the-glymphatic-pathway
#1
Helene Benveniste, Hedok Lee, Nora D Volkow
The overall premise of this review is that cerebrospinal fluid (CSF) is transported within a dedicated peri-vascular network facilitating metabolic waste clearance from the central nervous system while we sleep. The anatomical profile of the network is complex and has been defined as a peri-arterial CSF influx pathway and peri-venous clearance routes, which are functionally coupled by interstitial bulk flow supported by astrocytic aquaporin 4 water channels. The role of the newly discovered system in the brain is equivalent to the lymphatic system present in other body organs and has been termed the "glymphatic pathway" or "(g)lymphatics" because of its dependence on glial cells...
January 1, 2017: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/28448515/chronic-cocaine-induces-hif-vegf-pathway-activation-along-with-angiogenesis-in-the-brain
#2
Wei Yin, Kevin Clare, Qiujia Zhang, Nora D Volkow, Congwu Du
Cocaine induces vasoconstriction in cerebral vessels, which with repeated use can result in transient ischemic attacks and cerebral strokes. However, the neuroadaptations that follow cocaine's vasoconstricting effects are not well understood. Here, we investigated the effects of chronic cocaine exposure (2 and 4 weeks) on markers of vascular function and morphology in the rat brain. For this purpose we measured nitric oxide (NO) concentration in plasma, brain neuronal nitric oxide synthase (nNOS or NOS1), HIF-1α, and VEGF expression in different brain regions, i...
2017: PloS One
https://www.readbyqxmd.com/read/28445570/medical-marijuana-laws-and-cannabis-use-intersections-of-health-and-policy
#3
Wilson M Compton, Nora D Volkow, Marsha F Lopez
No abstract text is available yet for this article.
April 26, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28418460/marijuana-use-during-stages-of-pregnancy-in-the-united-states
#4
Nora D Volkow, Beth Han, Wilson M Compton, Carlos Blanco
No abstract text is available yet for this article.
May 16, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28416594/new-repeat-polymorphism-in-the-akt1-gene-predicts-striatal-dopamine-d2-d3-receptor-availability-and-stimulant-induced-dopamine-release-in-the-healthy-human-brain
#5
Elena Shumay, Corinde E Wiers, Ehsan Shokri-Kojori, Sung Won Kim, Colin A Hodgkinson, Hui Sun, Dardo Tomasi, Christopher T Wong, Daniel R Weinberger, Gene-Jack Wang, Joanna S Fowler, Nora D Volkow
The role of the protein kinase Akt1 in dopamine neurotransmission is well recognized and has been implicated in schizophrenia and psychosis. However, the extent to which variants in the AKT1 gene influence dopamine neurotransmission is not well understood. Here we investigated the effect of a newly characterized variant number tandem repeat (VNTR) polymorphism in AKT1 [major alleles: L- (eight repeats) and H- (nine repeats)] on striatal dopamine D2/D3 receptor (DRD2) availability and on dopamine release in healthy volunteers...
May 10, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28297025/association-of-stimulant-use-with-dopaminergic-alterations-in-users-of-cocaine-amphetamine-or-methamphetamine-a-systematic-review-and-meta-analysis
#6
Abhishekh H Ashok, Yuya Mizuno, Nora D Volkow, Oliver D Howes
Importance: Stimulant use disorder is common, affecting between 0.3% and 1.1% of the population, and costs more than $85 billion per year globally. There are no licensed treatments to date. Several lines of evidence implicate the dopamine system in the pathogenesis of substance use disorder. Therefore, understanding the nature of dopamine dysfunction seen in stimulant users has the potential to aid the development of new therapeutics. Objective: To comprehensively review the in vivo imaging evidence for dopaminergic alterations in stimulant (cocaine, amphetamine, or methamphetamine) abuse or dependence...
May 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28289715/cerebrovascular-adaptations-to-cocaine-induced-transient-ischemic-attacks-in-the-rodent-brain
#7
Jiang You, Nora D Volkow, Kicheon Park, Qiujia Zhang, Kevin Clare, Congwu Du, Yingtian Pan
Occurrence of transient ischemic attacks (TIA) and cerebral strokes is a recognized risk associated with cocaine abuse. Here, we use a rodent model along with optical imaging to study cocaine-induced TIA and the associated dynamic changes in cerebral blood flow velocity (CBFv) and cerebrovasculature. We show that chronic cocaine exposure in mice resulted in marked cortical hypoperfusion, in significant arterial and venous vasoconstriction, and in a sensitized vascular response to an acute cocaine injection...
March 9, 2017: JCI Insight
https://www.readbyqxmd.com/read/28261049/brain-network-dynamics-adhere-to-a-power-law
#8
Dardo G Tomasi, Ehsan Shokri-Kojori, Nora D Volkow
The temporal dynamics of complex networks such as the Internet are characterized by a power scaling between the temporal mean and dispersion of signals at each network node. Here we tested the hypothesis that the temporal dynamics of the brain networks are characterized by a similar power law. This realization could be useful to assess the effects of randomness and external modulators on the brain network dynamics. Simulated data using a well-stablished random diffusion model allowed us to predict that the temporal dispersion of the amplitude of low frequency fluctuations (ALFF) and that of the local functional connectivity density (lFCD) scale with their temporal means...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28178354/correction-chronic-methamphetamine-effects-on-brain-structure-and-function-in-rats
#9
Panayotis K Thanos, Ronald Kim, Foteini Delis, Mala Ananth, George Chachati, Mark J Rocco, Ihssan Masad, Jose A Muniz, Samuel C Grant, Mark S Gold, Jean Lud Cadet, Nora D Volkow
[This corrects the article DOI: 10.1371/journal.pone.0155457.].
2017: PloS One
https://www.readbyqxmd.com/read/28112677/seeing-how-we-smell
#10
Helene Benveniste, Yuri Lazebnik, Nora D Volkow
PET allows noninvasive imaging of a variety of events in the body, including the activity of neuronal circuits in the brain that are involved in cognition and behaviors, by using radiotracers that detect relevant biological reactions. A major impediment to expanding PET applications to study the brain has been the lack of radiotracers that can identify and measure specific types of neurons or glial cells. In this issue of the JCI, Van de Bittner and colleagues describe a promising step toward solving this problem by identifying and describing a radiotracer, [11C]GV1-57, that appears to specifically label olfactory sensory neurons (OSNs), which are essential for olfaction (Figure 1)...
February 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28108358/neurochemical-and-metabolic-effects-of-acute-and-chronic-alcohol-in-the-human-brain-studies-with-positron-emission-tomography
#11
REVIEW
Nora D Volkow, Corinde E Wiers, Ehsan Shokri-Kojori, Dardo Tomasi, Gene-Jack Wang, Ruben Baler
The use of Positron emission tomography (PET) to study the effects of acute and chronic alcohol on the human brain has enhanced our understanding of the mechanisms underlying alcohol's rewarding effects, the neuroadaptations from chronic exposure that contribute to tolerance and withdrawal, and the changes in fronto-striatal circuits that lead to loss of control and enhanced motivation to drink that characterize alcohol use disorders (AUD). These include studies showing that alcohol's reinforcing effects may result not only from its enhancement of dopaminergic, GABAergic and opioid signaling but also from its caloric properties...
January 18, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/27993694/effects-of-chronic-methamphetamine-on-psychomotor-and-cognitive-functions-and-dopamine-signaling-in-the-brain
#12
Panayotis K Thanos, Ronald Kim, Foteini Delis, Mark J Rocco, Jacob Cho, Nora D Volkow
Methamphetamine (MA) studies in animals usually involve acute, binge, or short-term exposure to the drug. However, addicts take substantial amounts of MA for extended periods of time. Here we wished to study the effects of MA exposure on brain and behavior, using an animal model analogous to this pattern of MA intake. MA doses, 4 and 8mg/kg/day, were based on previously reported average daily freely available MA self-administration levels. We examined the effects of 16 week MA treatment on psychomotor and cognitive function in the rat using open field and novel object recognition tests and we studied the adaptations of the dopaminergic system, using in vitro and in vivo receptor imaging...
March 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27992628/the-risks-of-marijuana-use-during-pregnancy
#13
Nora D Volkow, Wilson M Compton, Eric M Wargo
No abstract text is available yet for this article.
January 10, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27959513/expression-of-hdac2-but-not-hdac1-transcript-is-reduced-in-dorsolateral-prefrontal-cortex-of-patients-with-schizophrenia
#14
Frederick A Schroeder, Tonya M Gilbert, Ningping Feng, Brendan D Taillon, Nora D Volkow, Robert B Innis, Jacob M Hooker, Barbara K Lipska
Postmortem brain studies support dysregulated expression of the histone deacetylase enzymes, HDAC1 and HDAC2, as a central feature in diseases including schizophrenia, bipolar disorder, and depression. Our objective was to investigate HDAC expression in a large postmortem sample set representing healthy and disease brains. We used >700 well-characterized samples from patients diagnosed with schizophrenia (n = 175), major depressive disorder (n = 135), and bipolar disorder (n = 61) to measure HDAC1 and HDAC2 transcript levels by quantitative real-time PCR in dorsolateral prefrontal cortex (DLPFC) and caudate compared to control samples...
March 15, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27853201/the-effects-of-%C3%AE-9-tetrahydrocannabinol-on-the-dopamine-system
#15
REVIEW
Michael A P Bloomfield, Abhishekh H Ashok, Nora D Volkow, Oliver D Howes
The effects of Δ(9)-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, are a pressing concern for global mental health. Patterns of cannabis use are changing drastically owing to legalization, the availability of synthetic analogues (commonly termed spice), cannavaping and an emphasis on the purported therapeutic effects of cannabis. Many of the reinforcing effects of THC are mediated by the dopamine system. Owing to the complexity of the cannabinoid-dopamine interactions that take place, there is conflicting evidence from human and animal studies concerning the effects of THC on the dopamine system...
November 17, 2016: Nature
https://www.readbyqxmd.com/read/27774503/is-biological-aging-accelerated-in-drug-addiction
#16
Keren Bachi, Salvador Sierra, Nora D Volkow, Rita Z Goldstein, Nelly Alia-Klein
Drug-addiction may trigger early onset of age-related disease, due to drug-induced multi-system toxicity and perilous lifestyle, which remains mostly undetected and untreated. We present the literature on pathophysiological processes that may hasten aging and its relevance to addiction, including: oxidative stress and cellular aging, inflammation in periphery and brain, decline in brain volume and function, and early onset of cardiac, cerebrovascular, kidney, and liver disease. Timely detection of accelerated aging in addiction is crucial for the prevention of premature morbidity and mortality...
February 2017: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/27764663/re-energizing-the-development-of-pain-therapeutics-in-light-of-the-opioid-epidemic
#17
Phil Skolnick, Nora D Volkow
Limited options for treating moderate-severe pain led to an overreliance on opioids and the current opioid epidemic. Addressing the factors contributing to a dearth of effective alternatives and re-energizing the development of pain therapeutics is necessary to quell this epidemic.
October 19, 2016: Neuron
https://www.readbyqxmd.com/read/27739612/structural-and-functional-connectivity-of-the-precuneus-and-thalamus-to-the-default-mode-network
#18
Samantha I Cunningham, Dardo Tomasi, Nora D Volkow
Neuroimaging studies have identified functional interactions between the thalamus, precuneus, and default mode network (DMN) in studies of consciousness. However, less is known about the structural connectivity of the precuneus and thalamus to regions within the DMN. We used diffusion tensor imaging (DTI) to parcellate the precuneus and thalamus based on their probabilistic white matter connectivity to each other and DMN regions of interest (ROIs) in 37 healthy subjects from the Human Connectome Database. We further assessed resting-state functional connectivity (RSFC) among the precuneus, thalamus, and DMN ROIs...
October 14, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27618739/don-t-worry-be-happy-endocannabinoids-and-cannabis-at-the-intersection-of-stress-and-reward
#19
Nora D Volkow, Aidan J Hampson, Ruben D Baler
Cannabis enables and enhances the subjective sense of well-being by stimulating the endocannabinoid system (ECS), which plays a key role in modulating the response to stress, reward, and their interactions. However, over time, repeated activation of the ECS by cannabis can trigger neuroadaptations that may impair the sensitivity to stress and reward. This effect, in vulnerable individuals, can lead to addiction and other adverse consequences. The recent shift toward legalization of medical or recreational cannabis has renewed interest in investigating the physiological role of the ECS as well as the potential health effects, both adverse and beneficial, of cannabis...
January 6, 2017: Annual Review of Pharmacology and Toxicology
https://www.readbyqxmd.com/read/27551166/cocaine-induced-abnormal-cerebral-hemodynamic-responses-to-forepaw-stimulation-assessed-by-integrated-multi-wavelength-spectroimaging-and-laser-speckle-contrast-imaging
#20
Wei Chen, Kicheon Park, Nora Volkow, Yingtian Pan, Congwu Du
Simultaneous imaging of cerebral hemodynamic changes in response to functional activation during drug intoxication provides a valuable strategy to assess cocaine induced neurovascular dysfunction. However, this requires tools with sufficient spatiotemporal resolution and adequate signal to noise ratio (SNR). Though several technologies have been developed to address this demand during functional brain activation, their spatiotemporal resolution has been compromised to preserve SNR. In this study, we combine spatiotemporal-domain laser speckle contrast analysis and image correlation techniques to integrate multi-wavelength spectroimaging and laser speckle contrast imaging (MW-LSCI)...
July 2016: IEEE Journal of Selected Topics in Quantum Electronics
keyword
keyword
47232
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"