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https://www.readbyqxmd.com/read/28108922/association-between-heavy-metal-and-metalloid-levels-in-topsoil-and-cancer-mortality-in-spain
#1
Olivier Núñez, Pablo Fernández-Navarro, Iván Martín-Méndez, Alejandro Bel-Lan, Juan F Locutura Rupérez, Gonzalo López-Abente
Spatio-temporal cancer mortality studies in Spain have revealed patterns for some tumours which display a distribution that is similar across the sexes and persists over time. Such characteristics would be common to tumours that shared risk factors, including the geochemical composition of the soil. The aim of this study was to assess the possible association between heavy metal and metalloid levels in topsoil (upper soil horizon) and cancer mortality in mainland Spain. Ecological cancer mortality study at a municipal level, covering 861,440 cancer deaths (27 different tumour locations) in 7917 Spanish mainland towns, from 1999 to 2008...
January 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28108920/biochemical-and-physiological-responses-of-halophilic-nanophytoplankton-dunaliella-salina-from-exposure-to-xeno-estrogen-17%C3%AE-ethinylestradiol
#2
Dalel Belhaj, Khaled Athmouni, Doniez Frikha, Monem Kallel, Abdelfattah El Feki, Sami Maalej, John L Zhou, Habib Ayadi
The environmental impacts of various pollutants on the entire levels of organisms are under investigation. Among these pollutants, endocrine-disrupting compounds (EDCs) present a serious hazard, even though the environmental significance of these compounds remains basically unknown. To drop some light on this field, we assessed the effects of a 11-day exposure of 17α-ethinylestradiol (EE2) on the growth, metabolic content, antioxidant response, oxidative stress, and genetic damage of Dunaliella salina, isolated from Tunisian biotopes...
January 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28108908/diamine-oxidase-from-white-pea-lathyrus-sativus-combined-with-catalase-protects-the-human-intestinal-caco-2-cell-line-from-histamine-damage
#3
Catherine Jumarie, Marilyne Séïde, Lucia Marcocci, Paola Pietrangeli, Mircea Alexandru Mateescu
Diamine oxidase (DAO) administration has been proposed to treat certain gastrointestinal dysfunctions induced by histamine, an immunomodulator, signaling, and pro-inflammatory factor. However, H2O2 resulting from the oxidative deamination of histamine by DAO may be toxic. The purpose of this study was to investigate to which extent DAO from white pea (Lathyrus sativus), alone or in combination with catalase, may modulate histamine toxicity in the human intestinal Caco-2 cell line. The results show that histamine at concentrations higher than 1 mM is toxic to the Caco-2 cells, independently of the cell differentiation status, with a LC50 of ≅ 10 mM following a 24-h exposure...
January 20, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28108890/toxic-and-heavy-metals-as-a-cause-of-crayfish-mass-mortality-from-acidified-headwater-streams
#4
Jitka Svobodová, Karel Douda, David Fischer, Natalia Lapšanská, Pavel Vlach
Mining activities are responsible for high concentrations of metals in river networks in many parts of the world. Mining activities and the resulting high loads of heavy metals interact with intensive acid rain, and often have great consequences for biodiversity. However, considering the frequently episodic nature of these heavy acid rains, there is little detailed evidence of direct impacts. In 2011 we observed a massive mortality of noble crayfish and stone crayfish in Padrťsko Special Area of Conservation (SAC) in the Brdy Mountain region of the Czech Republic...
January 21, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28108889/hg-and-se-exposure-in-brain-tissues-of-striped-dolphin-stenella-coeruleoalba-and-bottlenose-dolphin-tursiops-truncatus-from-the-tyrrhenian-and-adriatic-seas
#5
Antonio Bellante, Fabio D'Agostino, Anna Traina, Daniela Piazzese, Maria Francesca Milazzo, Mario Sprovieri
In this study we analyzed Hg and Se concentrations in dolphin brain tissues of fifteen specimens of striped dolphin (Stenella coeruleoalba) and eight specimens of bottlenose dolphin (Tursiops truncatus) stranded in the Tyrrhenian and Adriatic Seas, in order to assess the toxicological risks associated with Hg exposure. High Hg concentrations were found in brain tissues of both analyzed specie (1.86-243 mg/kg dw for striped dolphin and 2.1-98.7 mg/kg dw for bottlenose dolphin), exceeding levels associated with marine mammals neurotoxicity...
January 21, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28108741/metabolism-toxicity-and-anticancer-activities-of-arsenic-compounds
#6
Islam Khairul, Qian Qian Wang, Yu Han Jiang, Chao Wang, Hua Naranmandura
A variety of studies indicated that inorganic arsenic and its methylated metabolites have paradoxical effects, namely, carcinogenic and anticancer effects. Epidemiological studies have shown that long term exposure to arsenic can increase the risk of cancers of lung, skin or bladder in man, which is probably associated with the arsenic metabolism. In fact, the enzymatic conversion of inorganic arsenic by Arsenic (+3 oxidation state) methyltransferase (AS3MT) to mono- and dimethylated arsenic species has long been considered as a major route for detoxification...
January 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28108177/discriminating-between-adaptive-and-carcinogenic-liver-hypertrophy-in-rat-studies-using-logistic-ridge-regression-analysis-of-toxicogenomic-data-the-mode-of-action-and-predictive-models
#7
Shujie Liu, Taisuke Kawamoto, Osamu Morita, Kouichi Yoshinari, Hiroshi Honda
Chemical exposure often results in liver hypertrophy in animal tests, characterized by increased liver weight, hepatocellular hypertrophy, and/or cell proliferation. While most of these changes are considered adaptive responses, there is concern that they may be associated with carcinogenesis. In this study, we have employed a toxicogenomic approach using a logistic ridge regression model to identify genes responsible for liver hypertrophy and hypertrophic hepatocarcinogenesis and to develop a predictive model for assessing hypertrophy-inducing compounds...
January 17, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28108117/a-single-intervention-for-cockroach-control-reduces-cockroach-exposure-and-asthma-morbidity-in-children
#8
Felicia A Rabito, John C Carlson, Hua He, Derek Werthmann, Coby Schal
BACKGROUND: Exposure to cockroaches is an important asthma trigger, particularly for children with asthma living in inner cities. Integrated pest management is the recommended approach to cockroach abatement; however, it is costly and difficult to implement. The impact of reducing cockroach exposure on asthma outcomes is not known. OBJECTIVE: We sought to test the use of a single intervention, insecticidal bait, to reduce cockroach exposure in the home of children with asthma in New Orleans and to examine the impact of cockroach reduction on asthma outcomes...
January 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28107742/heavy-rare-earth-elements-affect-early-life-stages-in-paracentrotus-lividus-and-arbacia-lixula-sea-urchins
#9
Rahime Oral, Giovanni Pagano, Antonietta Siciliano, Maria Gravina, Anna Palumbo, Immacolata Castellano, Oriana Migliaccio, Philippe J Thomas, Marco Guida, Franca Tommasi, Marco Trifuoggi
BACKGROUND: Heavy rare earth elements (HREEs) have been scarcely studied for their toxicity, in spite of their applications in several technologies. Thus HREEs require timely investigations for their adverse health effects. METHODS: Paracentrotus lividus and Arbacia lixula embryos and sperm were exposed to trichloride salts of five HREEs (Dy, Ho, Er, Yb and Lu) and to Ce(III) as a light REE (LREE) reference to evaluate: 1) developmental defects (% DD) in HREE-exposed larvae or in the offspring of HREE-exposed sperm; 2) mitotic anomalies; 3) fertilization success; and 4) reactive oxygen species (ROS) formation, and nitric oxide (NO) and malondialdehyde (MDA) levels...
January 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/28107620/chemical-interaction-of-protein-cysteine-residues-with-reactive-metabolites-of-methyleugenol
#10
Yukun Feng, Hui Wang, Qian Wang, Wenlin Huang, Ying Peng, Jiang Zheng
Methyleugenol (ME), an alkenylbenzene compound, is a natural ingredient of several herbs and is used as flavoring agent in foodstuffs and fragrance in cosmetics. The hepatotoxicity, cytotoxicity, and carcinogenesis of ME have been well documented, and metabolic activation has been suggested to involve in ME-induced toxicities. The objective of this study was to identify chemical identity of interactions of protein with reactive metabolites of ME. Modification of cysteine residues of protein was observed in microsomal incubations and mice after exposure to ME...
January 20, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28107509/development-of-combining-of-human-bronchial-mucosa-models-with-xposeali%C3%A2-for-exposure-of-air-pollution-nanoparticles
#11
Jie Ji, Anna Hedelin, Maria Malmlöf, Vadim Kessler, Gulaim Seisenbaeva, Per Gerde, Lena Palmberg
BACKGROUND: Exposure to agents via inhalation is of great concerns both in workplace environment and in the daily contact with particles in the ambient air. Reliable human airway exposure systems will most likely replace animal experiment in future toxicity assessment studies of inhaled agents. METHODS: In this study, we successfully established a combination of an exposure system (XposeALI) with 3D models mimicking both healthy and chronic bronchitis-like mucosa by co-culturing human primary bronchial epithelial cells (PBEC) and fibroblast at air-liquid interface (ALI)...
2017: PloS One
https://www.readbyqxmd.com/read/28106810/genetic-aspects-of-susceptibility-to-mercury-toxicity-an-overview
#12
REVIEW
Virginia Andreoli, Francesca Sprovieri
Human exposure to mercury is still a major public health concern. In this context, children have a higher susceptibility to adverse neurological mercury effects, compared to adults with similar exposures. Moreover, there exists a marked variability of personal response to detrimental mercury action, in particular among population groups with significant mercury exposure. New scientific evidence on genetic backgrounds has raised the issue of whether candidate susceptibility genes can make certain individuals more or less vulnerable to mercury toxicity...
January 18, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28106287/an-assessment-of-direct-and-indirect-effects-of-two-herbicides-on-aquatic-communities
#13
Simone Hasenbein, Sharon P Lawler, Richard E Connon
Herbicides are often detected in watersheds at concentrations that are toxic to phytoplankton, potentially causing indirect effects on higher trophic organisms. The long-term effects of 5 applications over 30 days of binary mixtures of the herbicides diuron and hexazinone were assessed at 'low' and 'high' concentrations typically found in the environment. Sixteen of 95 phytoplankton taxa, 3 of 18 zooplankton taxa, and 6 of 14 macroinvertebrate taxa responded negatively to contaminant exposures. Herbicide applications altered the phytoplankton community structure...
January 20, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28105575/bongkrekic-acid-a-review-of-a-lesser-known-mitochondrial-toxin
#14
REVIEW
Mehruba Anwar, Amelia Kasper, Alaina R Steck, Joshua G Schier
INTRODUCTION: Bongkrekic acid (BA) has a unique mechanism of toxicity among the mitochondrial toxins: it inhibits adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid is produced by the bacterium Burkholderia gladioli pathovar cocovenenans (B. cocovenenans) which has been implicated in outbreaks of food-borne illness involving coconut- and corn-based products in Indonesia and China. Our objective was to summarize what is known about the epidemiology, exposure sources, toxicokinetics, pathophysiology, clinical presentation, and diagnosis and treatment of human BA poisoning...
January 19, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28105571/metal-stress-in-zooplankton-diapause-production-post-hatching-response
#15
Adriana Aránguiz-Acuña, Pablo Pérez-Portilla
Aquatic organisms commonly respond to harsh conditions by forming diapausing stages, which enable populations to survive adverse periods forming egg banks. Production of diapausing eggs is frequently observed in monogonont rotifers, previously changing from asexual to partial sexual reproduction (mixis). In despite that zooplankton are frequently used in ecotoxicological assessment because of their sensitivity to various toxicants and their important role in the ecosystems, toxicity evaluations often consider the directly exposed population produced by parthenogenetic reproduction, exclusively...
January 19, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28105488/effects-of-ceo2-nanoparticles-on-terrestrial-isopod-porcellio-scaber-comparison-of-ceo2-biological-potential-with-other-nanoparticles
#16
Olga Malev, Polonca Trebše, Małgorzata Piecha, Sara Novak, Bojan Budič, Miroslav D Dramićanin, Damjana Drobne
Nano-sized cerium dioxide (CeO2) particles are emerging as an environmental issue due to their extensive use in automobile industries as fuel additives. Limited information is available on the potential toxicity of CeO2 nanoparticles (NPs) on terrestrial invertebrates through dietary exposure. In the present study, the toxic effects of CeO2 NPs on the model soil organism Porcellio scaber were evaluated. Nanotoxicity was assessed by monitoring the lipid peroxidation (LP) level and feeding rate after 14-days exposure to food amended with nano CeO2...
January 19, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28104343/thyroid-pathology-in-deer-mice-peromyscus-maniculata-from-a-reclaimed-mine-site-on-the-athabasca-oil-sands
#17
Ahmad Movasseghi, Jaime Rodríguez-Estival, Judit E G Smits
Information on naturally occurring thyroid disease in wild animals in general and in small mammals specifically is extremely limited. In the present field-based work, we investigated the structure and function of thyroid glands of deer mice (Peromyscus maniculata) studied as sentinels of ecosystem sustainability on reclaimed areas post-mining on the oil sands of northeastern Alberta, because of their greater sensitivity to contaminants relative to meadow voles (Microtus pennsylvanicus) on the same sites. Extraction of bitumen in the oil sands of northeastern Alberta, results in the release of contaminants including polycyclic aromatic compounds (PACs), metals, and metalloids to the environment that have a measurable biological cost to wildlife living in the affected areas...
January 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28104341/water-level-fluctuations-influence-sediment-porewater-chemistry-and-methylmercury-production-in-a-flood-control-reservoir
#18
Chris S Eckley, Todd P Luxton, Jennifer Goetz, John McKernan
Reservoirs typically have elevated fish mercury (Hg) levels compared to natural lakes and rivers. A unique feature of reservoirs is water-level management which can result in sediment exposure to the air. The objective of this study is to identify how reservoir water-level fluctuations impact Hg cycling, particularly the formation of the more toxic and bioaccumulative methylmercury (MeHg). Total-Hg (THg), MeHg, stable isotope methylation rates and several ancillary parameters were measured in reservoir sediments (including some in porewater and overlying water) that are seasonally and permanently inundated...
January 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28103841/a-two-site-two-arm-34-week-double-blind-parallel-group-randomized-controlled-trial-of-reduced-nicotine-cigarettes-in-smokers-with-mood-and-or-anxiety-disorders-trial-design-and-protocol
#19
Sophia I Allen, Jonathan Foulds, Gladys N Pachas, Susan Veldheer, Corinne Cather, Nour Azzouz, Shari Hrabovsky, Ahmad Hameed, Jessica Yingst, Erin Hammett, Jennifer Modesto, Nicolle M Krebs, Junjia Zhu, Jason Liao, Joshua E Muscat, John Richie, A Eden Evins
BACKGROUND: The U.S. Food and Drug Administration can set standards for cigarettes that could include reducing their nicotine content. Such a standard should improve public health without causing unintended serious consequences for sub-populations. This study evaluates the effect of progressive nicotine reduction in cigarettes on smoking behavior, toxicant exposure, and psychiatric symptoms in smokers with comorbid mood and/or anxiety disorders using a two-site, two-arm, double-blind, parallel group, randomized controlled trial (RCT) in four phases over 34 weeks...
January 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28103486/combined-toxic-effects-and-mechanisms-of-microsystin-lr-and-copper-on-vallisneria-natans-lour-hara-seedlings
#20
Zhi Wang, Junqian Zhang, Enhua Li, Liang Zhang, Xuelei Wang, Lirong Song
Microcystin-LR (MCLR) and copper are commonly found in eutrophic water bodies because of eutrophic run-offs, cyanobacterial blooms, and copper algicide applications. However, the ecotoxicological risk of their combination remains unknown. This study investigated the effect of MCLR, Cu, and their mixture on the growth and physiological responses of Vallisneria natans. Results showed that the combined toxicity of them was concentration dependent. Synergistic effects were elicited at low concentrations of MCLR and Cu exposure (≤0...
January 3, 2017: Journal of Hazardous Materials
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