keyword
MENU ▼
Read by QxMD icon Read
search

Toxic exposure

keyword
https://www.readbyqxmd.com/read/28724248/exposure-to-particulate-air-pollution-during-early-pregnancy-is-associated-with-placental-dna-methylation
#1
Jing Cai, Yan Zhao, Pengcheng Liu, Bin Xia, Qingyang Zhu, Xiu Wang, Qi Song, Haidong Kan, Yunhui Zhang
Maternal exposure to particulate matter with aerodynamic diameter <10μm (PM10) during pregnancy results in adverse birth outcomes. Changes in placental DNA methylation might mediate those adverse effects. In this study, we examined the associations between prenatal PM10 exposure and DNA methylation of LINE1, HSD11B2 and NR3C1 in human placenta. One hundred and eighty-one mother newborn pairs (80 fetal growth restriction newborns, 101 normal newborns) participated in this study. The average PM10 exposure of each trimester and of the whole pregnancy was calculated using daily air pollution concentration data...
July 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724220/influence-of-temperature-in-pollution-induced-community-tolerance-approaches-used-to-assess-effects-of-copper-on-freshwater-phototrophic-periphyton
#2
Anne Sophie Lambert, Aymeric Dabrin, Arnaud Foulquier, Soizic Morin, Christophe Rosy, Marina Coquery, Stéphane Pesce
By measuring levels of tolerance to toxicants in microbial communities using functional toxicity tests under controlled conditions, pollution-induced community tolerance (PICT) approaches offer an effect-based tool to assess the ecological risk of chemicals in aquatic systems. However, induced tolerance of exposed microbial communities cannot always be attributed solely to the presence of toxicants as various environmental factors, such as temperature, can also be involved. Several PICT studies have been conducted to assess the effects of copper (Cu) on phototrophic periphyton, but little is known about the influence of temperature on the response of these microbial communities to acute and chronic exposure to Cu...
July 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724214/potential-protective-effects-of-alpha-pinene-against-cytotoxicity-caused-by-aspirin-in-the-iec-6-cells
#3
Hafsia Bouzenna, Najla Hfaiedh, Marie-Agnès Giroux-Metges, Abdelfattah Elfeki, Hélène Talarmin
Alpha-pinene is a key compound of the essential oils extracted from many species of coniferous trees. It is known for its biological activities. The aim of the present study was to determine the preventive effect of alpha-pinene on aspirin-induced toxicity in vitro, using IEC-6 cells, and to investigate its antioxidant activities. The antioxidant activities were determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP). The cytotoxicity and oxidative stress were detected by cell viability, antioxidant enzyme activity, malondialdehyde (MDA) and GSH production, and the activation of MAPK pathways...
July 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28723867/prediction-of-severe-toxicity-in-adult-patients-under-treatment-with-5-fluorouracil-a-prospective-cohort-study
#4
Carolina Vázquez, María Orlova, Federico Angriman, José N Minatta, Paula Scibona, María A Verzura, Esteban G Jáuregui, Heidy Díaz de Arce, María G Pallotta, Waldo H Belloso
5-Fluorouracil (5-FU) has long been used for the treatment of gastrointestinal tumors harboring interindividual variability in both the pharmacokinetic and the pharmacogenetic profiles, which in turn may lead to life-threatening toxicities. We carried out a prospective cohort study of adult patients initiating treatment with 5-FU between 2013 and 2015. Primary exposures of interest were the methylenetetrahydrofolate reductase single nucleotide polymorphism in exons 4 and 7 and 5'-untranslated region-thymidylate synthase VNTR genotypes, in addition to baseline clinical and demographic variables...
July 18, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28723674/nanoparticles-and-female-reproductive-system-how-do-nanoparticles-affect-oogenesis-and-embryonic-development
#5
REVIEW
Cong-Cong Hou, Jun-Quan Zhu
Along with the increasing application of nanoparticles (NPs) in many walks of life, environmental exposure to NPs has raised considerable health concerns. When NPs enter a pregnant woman's body through inhalation, venous injection, ingestion or skin permeation, maternal toxic stress reactions such as reactive oxygen species (ROS), inflammation, apoptosis and endocrine dyscrasia are induced in different organs, particularly in the reproductive organs. Recent studies have shown that NPs disturb the developing oocyte by invading the protective barrier of theca cells, granulosa cell layers and zona pellucida...
July 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723108/oral-exposure-of-silver-nanoparticles-or-silver-ions-may-aggravate-fatty-liver-disease-in-overweight-mice
#6
Jianbo Jia, Feifei Li, Hongyu Zhou, Yuhong Bai, Sijin Liu, Yiguo Jiang, Guibin Jiang, Bing Yan
As the applications and environmental release of silver ions and nanoparticles are increasing, growing human exposures to these pollutants have become an emerging health concerns. The impeding effects of such pollutants on susceptible populations are severely under-studied. Here, we demonstrate that Ag NPs, at a dose that causes no general toxicity in normal mice, promote the progression of fatty liver disease from steatosis to steatohepatitis only in overweight mice. Exposure to Ag+ ions induces the same effects in overweight mice...
July 19, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28722828/bioaccumulation-based-silver-nanoparticle-toxicity-in-daphnia-magna-and-maternal-impacts
#7
Sunandan Pakrashi, Cheng Tan, Wen-Xiong Wang
In this study, we tested whether the bioaccumulation in specific tissues of Daphnia magna could explain silver nanoparticles (AgNPs) toxicity. Daphnids were exposed to different concentrations of well suspended AgNPs and AgNO3 . The accumulations of Ag in the whole body, guts and non-gut tissues, as well as the mortality of daphnids were recorded over a period of 7 days. Regression analysis showed higher degree of positive correlation between the concentration of Ag in the non-gut tissues than gut tissues and the mortality of the daphnids...
July 19, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28722781/contribution-of-pyrethroids-in-large-urban-rivers-to-sediment-toxicity-assessed-with-benthic-invertebrates-chironomus-dilutus-a-case-study-in-south-china
#8
Fei Cheng, Huizhen Li, Hongxue Qi, Qian Han, Jing You
The importance of pyrethroids as potential stressors to benthic organisms has gradually become evident in urban creeks, however, the occurrence and toxicity of sediment-associated pyrethroids are rarely studied in large rivers. In this context, ten sediments from a large urban river (Guangzhou reach of the Pearl River in China) were assessed for pyrethroid occurrence and sediment toxicity to the benthic invertebrate Chironomus dilutus. Half of the sediments exhibited lethality to C. dilutus in a 10-d exposure and all survived midges showed significant change of enzymatic activity...
July 19, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28722486/neurotoxic-effects-of-subchronic-intratracheal-mn-nanoparticle-exposure-alone-and-in-combination-with-other-welding-fume-metals-in-rats
#9
Zsuzsanna Máté, Edina Horváth, András Papp, Krisztina Kovács, Etelka Tombácz, Dániel Nesztor, Tamás Szabó, Andrea Szabó, Edit Paulik
Manganese (Mn) is a toxic heavy metal exposing workers in various occupational settings and causing, among others, nervous system damage. Metal fumes of welding, a typical source of Mn exposure, contain a complex mixture of metal oxides partly in nanoparticle form. As toxic effects of complex substances cannot be sufficiently understood by examining its components separately, general toxicity and functional neurotoxicity of a main pathogenic welding fume metal, Mn, was examined alone and combined with iron (Fe) and chromium (Cr), also frequently found in fumes...
July 19, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28722443/quantum-dot-nanotoxicity-investigations-using-human-lung-cells-and-toxor-electrochemical-enzyme-assay-methodology
#10
Tony O'Hara, Brian Seddon, Andrew O'Connor, Siobhán McClean, Baljit Singh, Emmanuel Iwuoha, Xolile Fuku, Eithne Dempsey
Recent studies have suggested that certain nanomaterials can interfere with optically based cytotoxicity assays resulting in underestimations of nanomaterial toxicity. As a result there has been growing interest in the use of whole cell electrochemical biosensors for nanotoxicity applications. Herein we report application of an electrochemical cytotoxicity assay developed in house (TOXOR) in the evaluation of toxic effects of mercaptosuccinic acid capped cadmium telluride quantum dots (MSA capped CdTe QDs), toward mammalian cells...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722422/first-time-view-on-human-metabolome-changes-after-a-single-intake-of-3-4-methylenedioxymethamphetamine-mdma-in-healthy-placebo-controlled-subjects
#11
Martina I Boxler, Matthias E Liechti, Yasmin Schmid, Thomas Kraemer, Andrea E Steuer
3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy') is widely consumed recreationally. Currently little is known about its effects on the human metabolome. Mapping biochemical changes after drug exposure can complement traditional approaches by revealing potential biomarkers of organ toxicity or discovering new metabolomic features in a time- and dose-dependent manner. We aimed to analyze for the first time plasma samples from a randomized, double-blind, placebo-controlled crossover study in healthy adults to explore changes in endogenous plasma metabolites following a single intake of MDMA...
July 19, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28722244/risk-of-liver-decompensation-with-cumulative-use-of-mitochondrial-toxic-nucleoside-analogues-in-hiv-hepatitis-c-virus-coinfection
#12
Vincent Lo Re Rd, Bret Zeldow, Michael J Kallan, Janet P Tate, Dena M Carbonari, Sean Hennessy, Jay R Kostman, Joseph K Lim, Matthew Bidwell Goetz, Robert Gross, Amy C Justice, Jason A Roy
PURPOSE: Among patients dually infected with human immunodeficiency virus (HIV) and chronic hepatitis C virus (HCV), use of antiretroviral therapy (ART) containing mitochondrial toxic nucleoside reverse transcriptase inhibitors (mtNRTIs) might induce chronic hepatic injury, which could accelerate HCV-associated liver fibrosis and increase the risk of hepatic decompensation and death. METHODS: We conducted a cohort study among 1747 HIV/HCV patients initiating NRTI-containing ART within the Veterans Aging Cohort Study (2002-2009) to determine if cumulative mtNRTI use increased the risk of hepatic decompensation and death among HIV-/HCV-coinfected patients...
July 19, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28721743/responses-of-human-hepatoma-hepg2-cells-to-silver-nanoparticles-and-polycyclic-aromatic-hydrocarbons
#13
Francisco Filipak Neto, Ludiana Cardoso da Silva, Samuel Liebel, Carmen Lúcia Voigt, Ciro Alberto de Oliveira Ribeiro
The nanotechnology has revolutionized the global market with silver nanoparticles (AgNP) occupying a prominent position due to their remarkable anti-bacterial properties. However, there is no data about the adverse and toxic effects of associations of AgNP and ubiquitous compounds, such as polycyclic aromatic hydrocarbons (PAH). In the current study, we investigated the responses of HepG2 cells to realistic concentrations of AgNP (0.09, 0.9 and 9 ng ml(-1)) and mixture of PAH (30 and 300 ng ml(-1)), separately and in association...
July 19, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28721613/comparative-toxicity-of-seven-rare-earth-elements-in-sea-urchin-early-life-stages
#14
Marco Trifuoggi, Giovanni Pagano, Marco Guida, Anna Palumbo, Antonietta Siciliano, Maria Gravina, Daniel M Lyons, Petra Burić, Maja Levak, Philippe J Thomas, Antonella Giarra, Rahime Oral
The widespread use of rare earth elements (REEs) in a number of technological applications raises unanswered questions related to REE-associated adverse effects. We have previously reported on the multiple impact of some REEs on the early life stages of the sea urchin Paracentrotus lividus. The present investigation was to evaluate REE toxicity to early life stages in two unrelated sea urchin species, Sphaerechinus granularis and Arbacia lixula. The comparative toxicities were tested of seven REEs, namely yttrium, lanthanum, cerium, neodymium, samarium, europium and gadolinium as chloride salts at concentrations ranging from 10(-7) to 10(-4) M...
July 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28720860/altered-hippocampal-volume-and-functional-connectivity-in-males-with-internet-gaming-disorder-comparing-to-those-with-alcohol-use-disorder
#15
Eun Jin Yoon, Jung-Seok Choi, Heejung Kim, Bo Kyung Sohn, Hee Yeon Jung, Jun-Young Lee, Dai-Jin Kim, Sun-Won Park, Yu Kyeong Kim
Internet gaming disorder (IGD) has been conceptualized as a behavioral addiction and shares clinical, neuropsychological, and personality characteristics with alcohol use disorder (AUD), but IGD dose not entail brain exposure to toxic agents, which renders it different from AUD. To achieve a clear understanding of the neurobiological features of IGD, we aimed to identify morphological and functional changes in IGD and compare them with those in AUD. Individuals with IGD showed larger volume in the hippocampus/amygdala and precuneus than healthy controls (HCs)...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720398/perinatal-and-neonatal-use-of-paracetamol-for-pain-relief
#16
REVIEW
Karel Allegaert, John N van den Anker
Paracetamol (acetaminophen) is the most widely used drug to treat pain or fever in pregnant women or neonates, but its pharmacokinetics (PK) and pharmacodynamics (PD) warrant a focused analysis. During pregnancy, there is an important increase in paracetamol clearance. Consequently, it is reasonable to anticipate that the analgesic effect of paracetamol will decrease faster, whereas higher doses may result in even higher oxidative toxic metabolites. Therefore, most peripartal PD data relate to multimodal analgesia strategies...
July 15, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28720343/exposure-to-ambient-dichloromethane-in-pregnancy-and-infancy-from-industrial-sources-and-childhood-cancers-in-california
#17
Andrew S Park, Beate Ritz, Chenxiao Ling, Myles Cockburn, Julia E Heck
BACKGROUND: The incidence of childhood cancers has been increasing and environmental exposure to air toxics has been suggested as a possible risk factor. This study aims to explore ambient exposure to dichloromethane (methylene chloride). METHODS: We frequency matched by birth year approximately 20 cancer-free controls identified from birth records to all childhood cancers ages 0-5 in the California Cancer Registry diagnosed from 1988 to 2012; i.e. 13,636 cases and a total of 270,673 controls...
June 24, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28720289/transcriptomics-in-toxicology
#18
Pius Joseph
Xenobiotics, of which many are toxic, may enter the human body through multiple routes. Excessive human exposure to xenobiotics may exceed the body's capacity to defend against the xenobiotic-induced toxicity and result in potentially fatal adverse health effects. Prevention of the adverse health effects, potentially associated with human exposure to the xenobiotics, may be achieved by detecting the toxic effects at an early, reversible and, therefore, preventable stage. Additionally, an understanding of the molecular mechanisms underlying the toxicity may be helpful in preventing and/or managing the ensuing adverse health effects...
July 15, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28720099/association-between-genome-wide-copy-number-variation-and-arsenic-induced-skin-lesions-a-prospective-study
#19
Muhammad G Kibriya, Farzana Jasmine, Faruque Parvez, Maria Argos, Shantanu Roy, Rachelle Paul-Brutus, Tariqul Islam, Alauddin Ahmed, Muhammad Rakibuz-Zaman, Justin Shinkle, Vesna Slavkovich, Joseph H Graziano, Habibul Ahsan
BACKGROUND: Exposure to arsenic in drinking water is a global health problem and arsenic-induced skin lesions are hallmark of chronic arsenic toxicity. We and others have reported germline genetic variations as risk factors for such skin lesions. The role of copy number variation (CNV) in the germline DNA in this regard is unknown. METHODS: From a large prospectively followed-up cohort, exposed to arsenic, we randomly selected 2171 subjects without arsenic-induced skin lesions at enrollment and genotyped their whole blood DNA samples on Illumina Cyto12v2...
July 18, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28719877/functional-genomic-assessment-of-2-2-bis-bromomethyl-1-3-propanediol-induced-cytotoxicity-in-a-single-gene-knockout-library-of-e-%C3%A2-coli
#20
Miao Guan, Xiaowei Zhang
Functional gene fingerprinting of chemicals could be used to understand the direct gene-chemical interaction in the process of toxification from a genome-wide scale. 2, 2-bis (bromomethyl)-1, 3-propanediol (BMP) is a brominated flame retardant with widespread production but with very limited toxicological data. Here the cytotoxicity of BMP was assessed by Escherichia coli (E. coli) functional genome-wide knockout mutants screening and the underlying molecular mechanism was investigated. The median inhibition concentration (IC50) of BMP was 1...
July 9, 2017: Chemosphere
keyword
keyword
4723
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"