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https://www.readbyqxmd.com/read/28944831/vitamin-d-alleviates-lipopolysaccharide%C3%A2-induced-acute-lung-injury-via-regulation-of-the-renin%C3%A2-angiotensin-system
#1
Jun Xu, Jialai Yang, Jian Chen, Qingli Luo, Qiu Zhang, Hong Zhang
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the clinical manifestations of severe lung damage and respiratory failure. ALI and ARDS result are associated with high mortality in patients. At present, no effective treatments for ALI and ARDS exist. It is established that vitamin D exhibits anti‑inflammatory effects, however, the specific effect of vitamin D on ALI remains largely unknown. The aim of the present study was to investigate whether, and by which mechanism, vitamin D alleviates lipopolysaccharide (LPS)‑induced ALI...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944704/the-relationship-between-vitamin-d-level-and-erectile-dysfunction-in-patients-with-type-2-diabetes-mellitus
#2
Sema Basat, Rıdvan Sivritepe, Damla Ortaboz, Ecem Sevim Çalık, Eyüp Veli Küçük, Berkan Şimşek, Sabri Atay, Arzu Çalışgan
Recent studies have suggested that a relationship could exist between 25-hydroxyvitamin D [25(OH)D] deficiency and erectile dysfunction (ED). The present study evaluated the relationship between 25(OH)D levels and ED in male patients with type 2 diabetes mellitus (DM). The study included 98 patients with type 2 DM aged between 18-80 years. The International Index of Erectile Function (IIEF-5) Questionnaire was administered. The patients were divided into three groups according to IIEF-5 scoring: IIEF-5 score between 5-10, severe ED; IIEF-5 score between 11-20, moderate ED; IIEF-5 score between 21-25, no ED...
September 23, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28944524/changes-of-vitamin-d-levels-and-bone-turnover-markers-after-cpap-therapy-a-randomized-sham-controlled-trial
#3
Jenny Theorell-Haglöw, Camilla M Hoyos, Craig L Phillips, Brendon J Yee, Markus Herrmann, Tara C Brennan-Speranza, Ronald R Grunstein, Peter Y Liu
The aim was to investigate whether continuous positive airway pressure treatment could modulate serum vitamin D (25-hydroxyvitamin D) and bone turnover markers (collagen-type 1 cross-linked C-telopeptide, osteocalcin and N-terminal propeptide of type 1 collagen) in secondary analysis from a randomized controlled trial. Sixty-five continuous positive airway pressure-naïve male patients with obstructive sleep apnea (age = 49 ± 12 years, apnea-hypopnea index = 39.9 ± 17.7 events h(-1) , body mass index = 31...
September 25, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28944098/the-role-of-vitamin-k-status-in-cardiovascular-health-evidence-from-observational-and-clinical-studies
#4
REVIEW
A J van Ballegooijen, J W Beulens
PURPOSE OF REVIEW: Vitamin K is a fat-soluble vitamin required for the activation of several vitamin K-dependent proteins to confer functioning. A growing body of evidence supports that vitamin K has beneficial effects on bone and cardiovascular health. This review summarizes key evidence on vitamin K status as measured by circulating measures and cardiovascular outcomes. RECENT FINDINGS: Overall, observational studies indicate that low vitamin K status as measured by high dephosphorylated uncarboxylated matrix gla protein concentrations plays a potential role in cardiovascular disease development, particularly in high-risk and chronic kidney disease populations...
2017: Current Nutrition Reports
https://www.readbyqxmd.com/read/28944088/loss-of-the-vitamin-d-receptor-in-human-breast-and-prostate-cancers-strongly-induces-cell-apoptosis-through-downregulation-of-wnt-%C3%AE-catenin-signaling
#5
Yu Zheng, Trupti Trivedi, Ruby Cy Lin, Colette Fong-Yee, Rick Nolte, Jeline Manibo, Yunzhao Chen, Musharraf Hossain, Konstantin Horas, Colin Dunstan, Hong Zhou, Markus J Seibel
Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D, 1,25-dihydroxy-vitamin D [1,25(OH)2D] are mediated through binding to the vitamin D receptor (VDR). Here, we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro...
2017: Bone Research
https://www.readbyqxmd.com/read/28943574/prolonged-hypocalcemia-following-a-single-dose-of-denosumab-for-diffuse-bone-metastasis-of-gastric-cancer-after-total-gastrectomy
#6
Sakura Iizumi, Tatsunori Shimoi, Tadaaki Nishikawa, Atsuko Kitano, Shinsuke Sasada, Akihiko Shimomura, Emi Noguchi, Mayu Yunokawa, Kan Yonemori, Chikako Shimizu, Yasuhiro Fujiwara, Kenji Tamura
Hypocalcemia is a significant adverse effect of denosumab. We herein report a case of prolonged hypocalcemia in a patient with multiple risk factors for hypocalcemia, including gastrectomy, increased bone turnover, and a poor performance status. Hypocalcemia developed after denosumab treatment for diffuse bone metastasis of gastric cancer, despite oral supplementation with vitamin D and calcium. To avoid serious prolonged hypocalcemia, a thorough assessment of the bone calcium metabolism is required before initiating denosumab treatment...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28943436/vitamin-d-receptor-protects-glioblastoma-a172%C3%A2-cells-against-coxsackievirus-a16-infection-induced-cell-death-in-the-pathogenesis-of-hand-foot-and-mouth-disease
#7
Meiling Qu, Shunxiang Di, Shuyun Zhang, Zhiqun Xia, Guohong Quan
Hand, foot, and mouth disease (HFMD) was one of the most common children illnesses. Coxsackievirus A16 was one of the major pathogens that cause HFMD. However, the role of vitamin D underlying this common illness has not been elucidated. Our study examined that vitamin D levels was significantly lower in 33 HFMD patients, compared to 36 healthy children. Unexpectedly, both mRNA and protein expression of VDR were significantly decreased in CA16 infected glioblastoma A172 cells. And overexpression of VDR or vitamin D treatment in CA16 infected glioblastoma A172 cells could reverse the CA16 infection induced cell death, apoptosis or mitochondrial membrane rupture...
September 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28943082/nutritional-rickets-in-taiwanese-children-experiences-at-a-single-center
#8
Li-Hsin Chuang, Yi-Ching Tung, Shih-Yao Liu, Cheng-Ting Lee, Huey-Ling Chen, Wen-Yu Tsai
BACKGROUND/PURPOSE: The number of children with nutritional rickets in Taiwan has increased over the last decade. The aim of this study was to present our experiences in the management of patients with this condition. PATIENTS AND METHODS: From 2011 to 2016, 10 children (3 boys and 7 girls) with nutritional rickets were enrolled in this study. Their clinical and biochemical data were analyzed. RESULTS: The median age of the 10 patients was 21 months (range, 12-25 months)...
September 21, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28942754/can-we-improve-the-nutritional-quality-of-meat
#9
Nigel D Scollan, Eleri M Price, Sarah A Morgan, Sharon A Huws, Kevin J Shingfield
The nutritional value of meat is an increasingly important factor influencing consumer preferences for poultry, red meat and processed meat products. Intramuscular fat content and composition, in addition to high quality protein, trace minerals and vitamins are important determinants of nutritional value. Fat content of meat at retail has decreased substantially over the past 40 years through advances in animal genetics, nutrition and management and changes in processing techniques. Evidence of the association between diet and the incidence of human non-communicable diseases has driven an interest in developing production systems for lowering total SFA and trans fatty acid (TFA) content and enrichment of n-3 PUFA concentrations in meat and meat products...
September 25, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/28942549/the-effect-of-vitamin-d-status-on-pain-lower-limb-strength-and-knee-function-during-balance-recovery-in-people-with-knee-osteoarthritis-an-exploratory-study
#10
Pazit Levinger, Rezaul Begg, Kerrie M Sanders, Hanatsu Nagano, Calum Downie, Aaron Petersen, Alan Hayes, Flavia Cicuttini
The association between vitamin D and muscle function associated with balance recovery and falls in people with knee osteoarthritis is unclear. Those with vitamin D insufficiency demonstrated poorer knee function during balance recovery, greater pain and locomotor dysfunction. Vitamin D insufficiency may have an adverse effect on muscle power function. PURPOSE: Low vitamin D status in people with knee osteoarthritis (OA) is often reported to be associated with increased pain and locomotor dysfunction...
September 23, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28942438/retraction-statement-paper-low-dose-vitamin-d-prevents-muscular-atrophy-and-reduces-falls-and-hip-fractures-in-women-after-stroke-a-randomized-controlled-trial-by-sato-et-al-cerebrovasc-dis-2005-20-187-192
#11
https://www.readbyqxmd.com/read/28942362/calcitriol-treatment-ameliorates-inflammation-and-blistering-in-mouse-models-of-epidermolysis-bullosa-acquisita
#12
Stefan Tukaj, Katja Bieber, Mareike Witte, Saeedeh Ghorbanalipoor, Enno Schmidt, Detlef Zillikens, Ralf J Ludwig, Michael Kasperkiewicz
A link between hypovitaminosis D and development of autoimmune bullous disorders has been recently suggested, but this association has not been experimentally elaborated. Here, the role of vitamin D was investigated in epidermolysis bullosa acquisita (EBA), an anti-type VII collagen autoantibody-induced blistering skin disease. Oral administration of the hormonally active vitamin D metabolite calcitriol ameliorated clinical disease severity and dermal neutrophil infiltration in both an antibody transfer- and immunization-induced EBA mouse model...
September 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28942038/the-enpp1-k121q-polymorphism-modulates-developing-of-bone-disorders-in-type-2-diabetes-a-cross-sectional-study
#13
Nahid Neamati, Seyed Reza Hosseini, Mahmood Hajiahmadi, Sohrab Halalkhor, Hajighorban Nooreddini, Haleh Akhavan Niaki, Bahare Korani, Hadi Parsian
BACKGROUND: Osteoporosis and osteopenia are common diseases in every population. Type 2 diabetes mellitus (T2DM) can lead to the development of various complications, such as bone disorders especially among elderly individuals. Studies suggested that ectonucleotide pyrophosphatase/phosphodiesterase1 (ENPP1) is contributed in insulin resistance and also the inhibition of bone mineralization. In this study, association of K121Q (rs1044498) polymorphism of the ENPP1 gene with T2DM and bone disorders is evaluated...
September 20, 2017: Gene
https://www.readbyqxmd.com/read/28941998/vitamin-d3-supplementation-decreases-a-unique-circulating-monocyte-cholesterol-pool-in-patients-with-type-2-diabetes
#14
Amy E Riek, Jisu Oh, Isra Darwech, Veronica Worthy, Xiaobo Lin, Richard E Ostlund, Rong M Zhang, Carlos Bernal-Mizrachi
Cross-sectional studies indicate consistent associations between low 25(OH)D concentration and increased risk of cardiovascular disease (CVD), but results of randomized control trials (RCTs) are mixed. However, the majority of the RCTs do not focus on type 2 diabetics, potentially obscuring the effects of vitamin D in this population. In vitro 1,25(OH)2D3 downregulates macrophage cholesterol deposition, but the in vivo effects are unknown. To explore potential mechanisms of the effects of vitamin D on CVD risk in patients with type 2 diabetes, we isolated monocytes in a subset of 26 patients from our RCT of diabetics with baseline serum 25(OH)D <25ng/mL randomized to vitamin D3 4000 IU/day or placebo for 4 months...
September 20, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28941472/vitamin-d-prevents-sunburn-tips-for-the-summer
#15
Daniel D Bikle
In the article by Scott et al, a high dose of vitamin D attenuated the inflammatory response to UV radiation in a small group of normal volunteers. The best results were in those subjects who had the greatest increase in circulating 25hydroxyvitamin D. Using microarray analyses these subjects showed a reduction in the expression of inflammatory markers with an increase in markers of skin barrier repair.
October 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28941306/influence-of-various-factors-on-circulating-25-oh-vitamin-d-concentrations-in-dogs-with-cancer-and-healthy-dogs
#16
N Weidner, J P Woods, P Conlon, K A Meckling, J L Atkinson, J Bayle, A J Makowski, R L Horst, A Verbrugghe
BACKGROUND: Low blood 25-hydroxyvitamin D (25(OH)D) concentrations have been associated with cancer in dogs. Little research has examined what other factors may affect 25(OH)D concentrations. OBJECTIVES: (1) To determine whether the presence of cancer (lymphoma, osteosarcoma, or mast cell tumor [MCT]) in dogs is associated with plasma 25(OH)D concentrations and (2) identify other factors related to plasma 25(OH)D concentrations in dogs. ANIMALS: Dogs newly diagnosed with osteosarcoma (n = 21), lymphoma (n = 27), and MCT (n = 21) presented to a tertiary referral oncology center, and healthy, client-owned dogs (n = 23)...
September 23, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28940579/treatment-of-psoriasis-with-topical-agents-recommendations-from-a-tuscany-consensus
#17
Andrea Chiricozzi, Nicola Pimpinelli, Federica Ricceri, Giovanni Bagnoni, Laura Bartoli, Mauro Bellini, Luca Brandini, Marzia Caproni, Antonio Castelli, Michele Fimiani, Franco Marsili, Carlo Mazzatenta, Maria Chiara Niccoli, Salvatore Panduri, Michele Pellegrino, Riccardo Sirna, Walter Volpi, Marco Romanelli, Francesca Prignano
Psoriasis is a chronic and relapsing inflammatory skin disease, clinically characterized by erythematous and scaly plaques. Treatment approach is mainly driven by disease severity, though several factors should be considered in order to identify the optimal therapeutic choice. Mild psoriasis may be treated with a wide array of topical agents including corticosteroids, vitamin D analogs, keratolytics, and calcipotriol/betamethasone propionate compound. Because guidelines may not provide practical indications regarding the therapeutic approach, the use of topical agents in psoriasis is more individually tailored...
September 20, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28940569/weekly-oral-bisphosphonates-over-two-years-prevent-bone-loss-in-cardiac-transplant-patients
#18
Uwe Lange, Katharina Classen, Ulf Müller-Ladner, Manfred Richter
BACKGROUND: Heart transplantation (HTX) is an established therapy for end-stage heart disease. The aim of this study was to determine whether application of oral bisphosphonates is effective in preventing osseous complications after HTX. METHODS: Thirty-three cardiac transplant recipients were treated with alendronate 70 mg/week or risedronate 35 mg/week in combination with 1000 mg calcium and 800 IU vitamin D. Markers of bone metabolism and dual energy X-ray absorptiometry (DXA) were determined directly after HTX and 2 years later...
September 23, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28940428/maternal-alcohol-use-and-nutrition-during-pregnancy-diet-and-anthropometry
#19
R Colin Carter, Marjanne Senekal, Neil C Dodge, Lori Bechard, Ernesta M Meintjes, Christopher D Molteno, Christopher Duggan, Joseph L Jacobson, Sandra W Jacobson
BACKGROUND: Despite known risks of prenatal nutritional deficiencies and studies documenting increased prevalence of poor dietary intake among non-pregnant alcohol abusers, the nutritional status of heavy drinking pregnant women remains largely unstudied. Animal models have found interactions between prenatal ethanol exposure and micronutrients, such as choline, folate, B12, and iron, and human studies have reported that lower maternal weight and body mass confer increased fetal alcohol-related risk...
September 20, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28940158/vitamin-d-and-osteoporosis-in-chronic-kidney-disease
#20
REVIEW
Paul Lips, David Goldsmith, Renate de Jongh
Osteoporotic fractures are common in patients with chronic kidney disease (CKD). Morbidity and mortality are higher in CKD patients with a fracture than in the general population. The assessment of bone mineral density for fracture prediction may be useful at all CKD stages. It should be considered when this influences treatment decisions. Vitamin D deficiency is common in patients with CKD, particularly in patients with proteinuria, due to loss of 25-hydroxyvitamin D and its binding protein. Vitamin D supplementation should be prescribed early in the course of renal disease...
September 23, 2017: Journal of Nephrology
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