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vitamine D

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https://www.readbyqxmd.com/read/29792983/impact-of-genetic-influence-on-serum-total-and-free-25-hydroxyvitamin-d-in-humans
#1
Balázs Szili, Boglárka Szabó, Péter Horváth, Bence Bakos, Györgyi Kirschner, János P Kósa, Erzsébet Toldy, Zsuzsanna Putz, Péter Lakatos, Ádám Tabák, István Takács
Serum 25-hydroxyvitamin D /25OHD/ levels in humans are determined primarily by environmental factors such as UV-B radiation and diet, including vitamin D intake. Although some genetic determinants of 25OHD levels have been shown, the magnitude of this association has not yet been clarified. The present study evaluates the genetic contribution to total- /t-25OHD/ and free-25OHD /f-25OHD/ in a representative sample of the Hungarian population (n = 462). The study was performed at the end of winter to minimize the effect of sunlight, which is a major determinant of serum vitamin D levels...
May 21, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29792782/25-hydroxyvitamin-d3-and-1-25-dihydroxyvitamin-d3-as-an-antiviral-and-immunomodulator-against-herpes-simplex-virus-1-infection-in-hela-cells
#2
Archit Kumar, Mini P Singh, Ragini S Kumar, Radha Kanta Ratho
The antiviral and immunomodulatory role of vitamin D has been shown in various viral infections. However, there is scanty literature available about the effect of vitamin D supplementation in herpes simplex virus-1 (HSV-1) infection. Therefore, the present study aimed to evaluate the role of two different forms of vitamin D: 25-hydroxyvitamin D3 (25D3) and 1,25-dihydroxyvitamin D3 (1,25D3) against HSV-1 in HeLa cells. The HeLa cells were supplemented with either 25D3 or 1,25D3 before HSV-1 infection and were studied after 6, 12, and 24 h postinfection (p...
May 24, 2018: Viral Immunology
https://www.readbyqxmd.com/read/29792375/knowledge-and-attitudes-of-family-doctors-dermatologists-and-endocrinologists-on-sun-exposure-and-vitamin-d
#3
Arif Abu-Abed, Said Azbarga, Roni Peleg
OBJECTIVES: Vitamin D is an important component of bone metabolism. Skin cells synthesize vitamin D when exposed to the sun. However, prolonged sun exposure damages the skin and increases the risk for skin cancer. The objective is to evaluate and compare the attitudes and recommendations of family doctors, dermatologists, and endocrinologists on exposure to the sun and vitamin D. METHODS: In a cross-sectional study, a questionnaire was completed by personal interview in a study population of 78 family doctors, 21 dermatologists, and 22 endocrinologists...
May 24, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29792047/annals-express-phenotyping-and-relative-quantification-of-vitamin-d-binding-protein-in-a-pediatric-population-by-liquid-chromatography-tandem-mass-spectrometry
#4
Ana Isabel Cillero, Eduardo Martínez-Morillo, Laura Mantecón, Mª Agustina Alonso, Helena Gil-Peña, Fernando Santos, Francisco V Alvarez
BACKGROUND: Adequate levels of vitamin D are required to ensure bone health and minimize the incidence of multiple extraskeletal diseases. Although total 25-hydroxyvitamin D (25OHD) remains the recommended biomarker for assessing vitamin D status, it has been speculated that free 25OHD correlates better with clinical outcomes. The calculation of free 25OHD depends on the levels of vitamin D binding protein (DBP), the determination of which involves different immunoassays and has led to varying results and conclusions...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29791721/persistence-of-treatment-with-biologics-for-patients-with-psoriasis-a-real-world-analysis-of-16-545-biologic-na%C3%A3-ve-patients-from-the-french-national-health-insurance-database-sniiram
#5
E Sbidian, M Mezzarobba, A Weill, J Coste, J Rudant
BACKGROUND: Long-term clinical effectiveness of biologics in psoriasis is needed. OBJECTIVES: We aimed to assess the long-term persistence of biologics used to treat psoriasis in a real-life setting. METHODS: All adults with psoriasis having been registered in the French national health insurance database (SNIIRAM) between 2008 and 2016 were eligible for inclusion. Psoriasis was defined as the fulfilment of at least two prescriptions for topical formulations of vitamin D derivative within a two-year period...
May 23, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29791509/health-outcomes-and-adherence-to-a-healthy-lifestyle-after-a-multimodal-intervention-in-people-with-multiple-sclerosis-three-year-follow-up
#6
Claudia H Marck, Alysha M De Livera, Chelsea R Brown, Sandra L Neate, Keryn L Taylor, Tracey J Weiland, Emily J Hadgkiss, George A Jelinek
BACKGROUND: Modifiable risk factors such as smoking and sedentary lifestyle adversely affect multiple sclerosis (MS) progression. Few multimodal behavioural interventions have been conducted for people with MS, and follow-up beyond 1 year is rare for lifestyle interventions. This study assessed adoption and adherence to healthy lifestyle behaviours and health outcomes 3 years after a lifestyle modification intervention, using generalized estimating equation models to account for within-participant correlation over time...
2018: PloS One
https://www.readbyqxmd.com/read/29790645/fibrinogen-prothrombin-time-derived-method-is-not-useful-in-patients-anticoagulated-with-low-molecular-weight-heparins-or-rivaroxaban
#7
C Duboscq, M Martinuzzo, J M Ceresetto, M Lopez, L Barrera, J Oyhamburu, G Stemmelin
BACKGROUND: Fibrinogen prothrombin time derived method (FIBPT-d) with photo-optical coagulometers is easy and economical. However, there are few reports on the behavior of this test on samples from patients anticoagulated with direct oral anticoagulants (DOACs) or low molecular weight heparin (LMWH). OBJECTIVE: To compare fibrinogen results obtained by Clauss method (FIB C) and FIBPT-d with two thromboplastins in anticoagulated patients. POPULATION: 295 consecutive anticoagulated patients: 99 vitamin K antagonist (VKA), 49 unfractionated heparin (UFH), 47 LMWH, 50 rivaroxaban and 50 dabigatran; and 100 healthy controls (NC)...
May 23, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29790402/vitamin-d-pathway-gene-polymorphisms-affecting-daclatasvir-plasma-concentration-at-2-weeks-and-1-month-of-therapy
#8
Jessica Cusato, Amedeo De Nicolò, Lucio Boglione, Fabio Favata, Alessandra Ariaudo, Simone Mornese Pinna, Chiara Carcieri, Federica Guido, Giuseppe Cariti, Giovanni Di Perri, Antonio D'Avolio
AIM: Vitamin D (VD) influences genetic expression through its receptor (VDR). VD pathway gene polymorphisms seem to influence antiviral drug pharmacokinetics and therapeutic outcome/toxicity. We investigated the association between daclatasvir (DCV) plasma concentrations and genetic variants (SNPs) associated with the VD pathway. PATIENTS & METHODS: Chronic hepatitis C patients treated with DCV from 2014 to 2016 were included. Genotypes were assessed through real-time PCR and plasma concentrations through liquid chromatography...
June 1, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29790199/relationship-between-cumulative-ultraviolet-exposure-and-cognitive-function-in-a-rural-elderly-chinese-population
#9
Shimeng Xin, Dechun Luan, Xue Wang, Fang Wang, Yang Liu, Qian Gao
OBJECTIVES: Some researchers have focused on the relationship between vitamin D and cognition, but the conclusions are inconsistent. We estimated cumulative UV exposure could be used to represent the individual's long-term vitamin D status and investigated its association with global cognitive function in elderly Chinese. METHODS: A total of 641 participants aged 60 years and over were recruited in a rural area of Shenyang, China. All were interviewed to obtain data regarding sociodemographic characteristics and time spent outdoors...
May 22, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29790130/an-analysis-of-mid-term-complications-weight-loss-and-type-2-diabetes-resolution-of-stomach-intestinal-pylorus-sparing-surgery-sips-versus-roux-en-y-gastric-bypass-rygb-with-three-year-follow-up
#10
Austin Cottam, Daniel Cottam, Hinali Zaveri, Samuel Cottam, Amit Surve, Walter Medlin, Christina Richards
BACKGROUND: For many years, the Roux-en-Y Gastric Bypass (RYGB) was considered a good balance of complications and weight loss. According to several short-term studies, single anastomosis duodenal switch or stomach intestinal pylorus sparing surgery (SIPS) offers similar weight loss to RYGB with fewer complications and better diabetes resolution. No one has substantiated mid-term complication and nutritional differences between these two procedures. This paper seeks to compare complication and nutritional outcomes between RYGB and SIPS...
May 22, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29790021/the-effect-of-cholecystectomy-on-25-hydroxyvitamin-d-levels-and-bone-mineral-density-in-postmenopausal-women
#11
Hatice Beyazal Polat, Munevver Serdaroglu Beyazal
Vitamin D deficiency has been reported in patients with gastrointestinal disorders. Little is known on the potentially deleterious effect of cholecystectomy on vitamin D levels and osteoporosis. We found that 25-hydroxyvitamin D levels and bone mineral density were lower in patients with prior cholecystectomy. PURPOSE: The influence of bile salts on vitamin D absorption is well-known, and increased incidence of vitamin D deficiency has been reported in patients with gastrointestinal disorders...
May 22, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29789712/distribution-and-determinants-of-retinol-in-norwegian-adolescents-and-its-relation-to-bone-mineral-density-the-troms%C3%A3-study-fit-futures
#12
M S W Teigmo, T E Gundersen, N Emaus, G Grimnes
BACKGROUND/OBJECTIVES: Sufficient vitamin A levels are important for many functions-and both too little and too much may have detrimental health effects. The aim of the study was to describe the distribution of retinol levels in Norwegian adolescents, the relation between lifestyle factors and retinol levels, and the relation between retinol levels and bone mineral density (BMD). SUBJECTS/METHODS: Serum retinol was measured in 414 girls and 474 boys aged 15-19 years, participating in the Tromsø Study: Fit Futures...
May 23, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29789711/physical-activity-but-not-sedentary-time-is-associated-with-vitamin-d-status-in-adolescents-study-of-cardiovascular-risk-in-adolescents-erica
#13
Ana Carla Moreira da Silva, Felipe Vogt Cureau, Cecília Lacroix de Oliveira, Denise Tavares Giannini, Katia Vergetti Bloch, Maria Cristina Caetano Kuschnir, Eliane Said Dutra, Beatriz D Schaan, Kênia Mara Baiocchi de Carvalho
BACKGROUND/OBJECTIVES: The association between active lifestyle components and vitamin D status in adolescents remains relatively unexplored. We aimed to investigate independent and joint associations of moderate-to-vigorous physical activity (MVPA) and screen time with serum 25-hydroxyvitamin D [25(OH)D] concentrations in adolescents. METHODS: This multicenter cross-sectional study involved 1152 Brazilian adolescents (age 12-17 years). Serum 25(OH)D was measured in a single laboratory and categorized as ≤20, 21-29, or ≥30 ng/mL...
May 23, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29789223/vitamin-d-status-in-diabetic-children-and-adolescents
#14
Tahereh Ziaei-Kajbaf, Majid Aminzadeh, Elham Fatahinezhad, Seyyed Mohammad-Hassan Aletayeb
INTRODUCTION: Besides its role in calcium homeostasis, vitamin D (VD) has an important immuno-mudulation effect. However, its role in autoimmune diseases such as type 1 diabetes is under discussion. This study designed to investigate serum VD status in children and adolescents with and without diabetes. MATERIALS AND METHODS: In a case-control study, 85 diabetic and 85 non-diabetic control (total 170) aged 1-15 yr. were enrolled. History of breast feeding and vitamin supplementation was obtained; growth indices and serum levels of Calcium, phosphorous, Alkaline-Phosphatase (ALP), Hemoglobin-A1c and VD were measured and analyzed...
March 16, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29788743/novel-insights-into-transcriptional-dysregulation-in-colorectal-cancer
#15
Y Feodorova, D Tashkova, I Koev, A Todorov, G Kostov, K Simitchiev, V Belovejdov, R Dimov, V Sarafian
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Although CRC has been comprehensively characterized at the molecular level, the tumor heterogeneity hinders the identification of reliable diagnostic, prognostic and predictive biomarkers. Molecular stratification of CRC is based on prevalent gene mutations and transcription profiles but its significance for clinical practice remains obscure. Indeed, activating mutations in the genes KRAS, NRAS and BRAF are the only predictive biomarkers for anti-EGFR antibody therapy routinely tested the clinic for advanced stages of CRC...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29788706/the-association-between-10-year-atherosclerotic-cardiovascular-diseases-risk-score-calculated-using-2013-american-college-of-cardiology-american-heart-association-guidelines-and-serum-25-hydroxyvitamin-d-level-among-aged-40-79-years-in-korea-the-sixth-korea
#16
Mun Hee Kim, Young Sang Kim, Hye Jin Oh, Yu Ri Kwon, Hye Won Kim
BACKGROUND: We examined the relationship between 10-year predicted atherosclerosis cardiovascular disease (ASCVD) risk score and 25-hydroxyvitamin D in Koreans aged 40-79 years. METHODS: A population-based, cross-sectional design was used from data based on the Korea National Health and Nutrition Examination Survey 2014. RESULTS: A total of 1,134 healthy Koreans aged 40-79 years were included. A positive relationship between serum 25-hydroxyvitamin D level and ASCVD score was shown in women (β=0...
May 2018: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29788436/s-25ohd-is-associated-with-hand-grip-strength-and-myopathy-at-five-years-in-girls-an-odense-child-cohort-study
#17
Rada Faris Al-Jwadi, Eva Jespersen, Christine Dalgård, Niels Bilenberg, Henrik Thybo Christesen
Context: Severe vitamin D deficiency may lead to myopathy in adults. Little is known about vitamin D and muscle strength in children. Objective: To test whether hand grip strength (HGS) in 5-year-old-children associates with serum 25-hydroxyvitamin D (s-25OHD) from pregnancy to five years. Methods: Observational study in the population-based Odense Child Cohort, Denmark. At five years, anthropometrics, body fat percentage by skin fold measurements and HGS were obtained (n=881)...
May 16, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29788364/effectiveness-of-prenatal-vitamin-d-deficiency-screening-and-treatment-program-a-stratified-randomized-field-trial
#18
Maryam Rostami, Fahimeh Ramezani Tehrani, Masoumeh Simbar, Razieh Bidhendi Yarandi, Sonia Minooee, Bruce W Hollis, Farhad Hosseinpanah
Context: Despite evidence on the association between hypovitaminosis D and adverse pregnancy outcomes and the positive impact of vitamin D supplementation, no evidence exists supporting a universal screening program in pregnancy as part of a routine prenatal care. Objective: We aimed at determining the effectiveness of a prenatal screening program on optimizing 25-hydroxyvitamin D(25(OH)D) levels and preventing pregnancy complications. Also, to identify a safe regimen, we compared several regimens in a subgroup of vitamin D deficient pregnant women...
May 18, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29788234/prediagnostic-serum-vitamin-d-levels-and-the-risk-of-crohn-s-disease-and-ulcerative-colitis
#19
Cong Dai, Min Jiang, Ming-Jun Sun
No abstract text is available yet for this article.
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788199/influences-of-trace-mineral-nutrition-and-maternal-flock-age-on-broiler-embryo-bone-development
#20
C A Torres, D R Korver
At hatch, the chick skeleton is a miniature of that of the adult bird. The hen deposits calcium, phosphorus, and trace minerals (copper, zinc, and manganese) along with vitamin D into the egg to allow development of the embryonic skeleton. The main source of calcium is the eggshell, whereas phosphorus, trace minerals, and vitamin D are mainly derived from the yolk. Calcium is absorbed from the eggshell and transferred to the embryo and yolk through the chorioallantoic membrane, whereas phosphorus and trace minerals are simultaneously mobilized by the yolk sac membrane...
May 21, 2018: Poultry Science
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