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https://www.readbyqxmd.com/read/29221963/detection-of-ige-reactivity-to-a-handful-of-allergen-molecules-in-early-childhood-predicts-respiratory-allergy-in-adolescence
#1
Magnus Wickman, Christian Lupinek, Niklas Andersson, Danielle Belgrave, Anna Asarnoj, Marta Benet, Mariona Pinart, Sandra Wieser, Judith Garcia-Aymerich, Alexandra Baar, Göran Pershagen, Angela Simpson, Inger Kull, Anna Bergström, Erik Melén, Carl Hamsten, Josep M Antó, Jean Bousquet, Adnan Custovic, Rudolf Valenta, Marianne van Hage
BACKGROUND: Sensitization in early childhood may precede respiratory allergy in adolescence. METHODS: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16years in a population based birth cohort (BAMSE). Symptoms were analyzed by questionnaire at ages 4, 8 and 16years. Clinically and independent relevant allergen molecules accounting for ≥90% of IgE reactivities in sensitized individuals and at all time-points were identified as risk molecules and used to predict respiratory allergy...
November 14, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29212027/melanoma-therapeutic-strategies-that-select-against-resistance-by-exploiting-myc-driven-evolutionary-convergence
#2
Katherine R Singleton, Lorin Crawford, Elizabeth Tsui, Haley E Manchester, Ophelia Maertens, Xiaojing Liu, Maria V Liberti, Anniefer N Magpusao, Elizabeth M Stein, Jennifer P Tingley, Dennie T Frederick, Genevieve M Boland, Keith T Flaherty, Shannon J McCall, Clemens Krepler, Katrin Sproesser, Meenhard Herlyn, Drew J Adams, Jason W Locasale, Karen Cichowski, Sayan Mukherjee, Kris C Wood
Diverse pathways drive resistance to BRAF/MEK inhibitors in BRAF-mutant melanoma, suggesting that durable control of resistance will be a challenge. By combining statistical modeling of genomic data from matched pre-treatment and post-relapse patient tumors with functional interrogation of >20 in vitro and in vivo resistance models, we discovered that major pathways of resistance converge to activate the transcription factor, c-MYC (MYC). MYC expression and pathway gene signatures were suppressed following drug treatment, and then rebounded during progression...
December 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/29170296/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#3
Katherine Wylie
No abstract text is available yet for this article.
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29170295/bet-1-can-the-manchester-acute-coronary-syndromes-and-troponin-only-manchester-acute-coronary-syndromes-decision-aids-rule-out-acute-coronary-syndromes-in-the-emergency-department
#4
Charles Reynard, Husam Ismail, Nicholas Hadden
A short-cut review was carried out to establish whether the Manchester Acute Coronary Syndromes (MACS) and Troponin-only MACS (T-MACS) decision aids can safely rule out acute coronary syndromes in patients presenting to the ED with suspected cardiac chest pain. Six studies were directly relevant to the question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated. The clinical bottom line is that both rules have high sensitivity for acute coronary syndromes, including the detection of major adverse cardiac events at 30 days...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28827293/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#5
Kerstin de Wit
No abstract text is available yet for this article.
September 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28724567/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#6
Janos Baombe
No abstract text is available yet for this article.
August 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28539372/toward-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#7
Craig Ferguson
No abstract text is available yet for this article.
June 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28319932/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#8
Bernard A Foëx
No abstract text is available yet for this article.
November 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27974430/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#9
Kevin Mackway-Jones
No abstract text is available yet for this article.
January 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27864393/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#10
Kevin C Mackway-Jones
No abstract text is available yet for this article.
December 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27651502/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#11
Kerstin Hogg
No abstract text is available yet for this article.
October 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27539979/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#12
Craig Ferguson, Body Richard
No abstract text is available yet for this article.
September 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27440769/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#13
Craig Ferguson
No abstract text is available yet for this article.
August 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27330181/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#14
Janos P Baombe
No abstract text is available yet for this article.
July 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27199141/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#15
Daniel Horner
No abstract text is available yet for this article.
June 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27099379/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#16
Kevin Mackway-Jones
No abstract text is available yet for this article.
May 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/26928460/non-interpenetrated-metal-organic-frameworks-based-on-copper-ii-paddlewheel-and-oligoparaxylene-isophthalate-linkers-synthesis-structure-and-gas-adsorption
#17
Yong Yan, Michal Juríček, François-Xavier Coudert, Nicolaas A Vermeulen, Sergio Grunder, Anne Dailly, William Lewis, Alexander J Blake, J Fraser Stoddart, Martin Schröder
Two metal-organic framework materials, MFM-130 and MFM-131 (MFM = Manchester Framework Material), have been synthesized using two oligoparaxylene (OPX) tetracarboxylate linkers containing four and five aromatic rings, respectively. Both fof-type non-interpenetrated networks contain Kagomé lattice layers comprising [Cu2(COO)4] paddlewheel units and isophthalates, which are pillared by the OPX linkers. Desolvated MFM-130, MFM-130a, shows permanent porosity (BET surface area of 2173 m(2)/g, pore volume of 1.0 cm(3)/g), high H2 storage capacity at 77 K (5...
March 16, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/26801490/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#18
Simon D Carley
No abstract text is available yet for this article.
February 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/26699190/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#19
Kevin Mackway-Jones
No abstract text is available yet for this article.
January 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/26598635/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#20
Kevin C Mackway-Jones, Simon Carley, Bernard A Foëx
No abstract text is available yet for this article.
December 2015: Emergency Medicine Journal: EMJ
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