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Keywords APACHE II score and critical i...

APACHE II score and critical illness

https://read.qxmd.com/read/38307525/comparison-of-mechanical-insufflation-exsufflation-and-hypertonic-saline-with-hyaluronic-acid-with-conventional-open-catheter-suctioning-in-intubated-patients
#21
JOURNAL ARTICLE
Miguel Sánchez-García, Manuel Álvarez-González, Sara Domingo-Marín, Ángela Del Pino-Ramírez, Fernando Martínez-Sagasti, Paloma González-Arenas, Carlos Cardenal-Sánchez, Elena Velasco-López, Antonio Núñez-Reiz
BACKGROUND: Open respiratory secretion suctioning with a catheter causes pain and injuries to the tracheobronchial mucosa in intubated patients. Mechanical insufflation-exsufflation (MI-E) aims at dragging secretions proximally non-invasively by generating a high peak expiratory airflow. Nebulized hypertonic saline with hyaluronic acid (HS-HA) facilitates suctioning by hydration. We assessed the safety and tolerance of a single session of airway clearance with MI-E and HS-HA in critically ill intubated patients...
February 2, 2024: Respiratory Care
https://read.qxmd.com/read/38293316/clinical-outcomes-and-risk-factors-for-death-in-critically-ill-patients-with-carbapenem-resistant-klebsiella-pneumoniae-treated-with-ceftazidime-avibactam-a-retrospective-study
#22
JOURNAL ARTICLE
Lingchun Zhang, Yani Ma, Chenglong Zhao, Shujuan Zhao, Lulu Zhao, Yuxin Yang, Yuhan Wang, Haiyang Meng, Jun Sun
PURPOSE: Carbapenem-Resistant Klebsiella pneumoniae (CRKP) is a significant public health threat, because it is associated with substantial morbidity and mortality. However, the risk factors associated with treatment failure of ceftazidime-avibactam (CAZ-AVI) and the need for CAZ-AVI-based combination remain unclear. METHODS: We conducted a retrospective study of critically ill patients (age: > 18 years) diagnosed with CRKP infections and treated with CAZ-AVI for at least 24 h between June 2020 and December 2022 at Henan Provincial People's Hospital...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38277179/effects-of-vibration-therapy-on-the-physical-function-of-critically-ill-adults-trial-a-randomized-controlled-trial
#23
JOURNAL ARTICLE
Satoshi Doi, Nobuto Nakanishi, Yoshimi Kawahara, Keiko Nomura, Mamiko Shima, Mie Shiraishi, Jun Oto
OBJECTIVES: Vibration therapy uses vibration to rehabilitate physical functions. Recently, it has been demonstrated to be safe for critically ill patients. However, its effects on physical functions are unclear. DESIGN: Randomized controlled trial. SETTING: A single-center, ICU. PATIENTS: Patients were randomly assigned to either vibration therapy coupled with protocolized mobilization or protocolized mobilization alone...
January 26, 2024: Critical Care Medicine
https://read.qxmd.com/read/38268267/prevalence-and-risk-factors-of-exposure-keratopathy-among-critically-ill-patients-a-systematic-review-and-meta-analysis
#24
REVIEW
Yulu Chen, Jing He, Qiuping Wu, Shi Pu, Caiping Song
AIMS: To identify the incidence, prevalence and risk factors of exposure keratopathy (EK) among critically ill patients. DESIGN: Systematic review and meta-analysis, in accordance with the PRISMA 2020 Statement. METHODS: The Cochrane Library, PubMed, Embase, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), China Knowledge Resource Integrated Database (CNKI), Chinese Biomedical Database (CBM), Weipu Database (VIP) and WanFang Database were systematically searched from inception to June 2022...
January 2024: Nursing Open
https://read.qxmd.com/read/38263967/prediction-of-mechanical-ventilation-outcome-by-early-abdominal-visceral-blood-flow-and-function-score-in-critically-ill-patients-after-cardiopulmonary-bypass-in-the-icu-a-prospective-observational-study
#25
JOURNAL ARTICLE
Chaofu Yue, Longxiang Su, Jun Wang, Na Cui, Yuankai Zhou, Wei Cheng, Bo Tang, Xi Rui, Huaiwu He, Yun Long
BACKGROUND: Abdominal organs are important organs that sense and respond to ischemia and hypoxia, but there are few evaluation methods.We use ultrasonography to evaluate abdominal organ function and blood flow in patients with mechanical ventilation (MV) after cardiopulmonary bypass and to obtain a semiquantitative score for abdominal organ function and blood flow. METHODS: Patients with cardiopulmonary bypass in the Critical Care Department of Peking Union Medical College Hospital in China from March to July 2021 were enrolled in this prospective observational study...
January 2024: J Intensive Med
https://read.qxmd.com/read/38259190/temporal-trends-in-mortality-of-critically-ill-patients-with-sepsis-in-the-united-kingdom-1988-2019
#26
JOURNAL ARTICLE
Hallie C Prescott, David A Harrison, Kathryn M Rowan, Manu Shankar-Hari, Hannah Wunsch
RATIONALE: Sepsis is a frequent cause of intensive care unit (ICU) admission and mortality. OBJECTIVES: To evaluate temporal trends in presentation and outcomes of patients admitted to the ICU with sepsis and assess the contribution of changing case mix on outcomes. METHODS: Retrospective cohort study of patients admitted to 261 ICUs in the United Kingdom during 1988-1990 and 1996-2019 with non-surgical sepsis. MEASUREMENTS AND MAIN RESULTS: 426,812 patients met study inclusion...
January 23, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38247902/using-signal-features-of-functional-near-infrared-spectroscopy-for-acute-physiological-score-estimation-in-ecmo-patients
#27
JOURNAL ARTICLE
Hsiao-Huang Chang, Kai-Hsiang Hou, Ting-Wei Chiang, Yi-Min Wang, Chia-Wei Sun
Extracorporeal membrane oxygenation (ECMO) is a vital emergency procedure providing respiratory and circulatory support to critically ill patients, especially those with compromised cardiopulmonary function. Its use has grown due to technological advances and clinical demand. Prolonged ECMO usage can lead to complications, necessitating the timely assessment of peripheral microcirculation for an accurate physiological evaluation. This study utilizes non-invasive near-infrared spectroscopy (NIRS) to monitor knee-level microcirculation in ECMO patients...
December 26, 2023: Bioengineering
https://read.qxmd.com/read/38238140/venous-to-arterial-carbon-dioxide-tension-difference-measurement-as-a-useful-predictor-of-patient-prognosis-after-major-surgery
#28
JOURNAL ARTICLE
Gyeo Ra Lee, Hye Sung Kim, Yoon Ji Chung, Eun Young Kim
PURPOSE: Change in venous-to-arterial carbon dioxide partial pressure difference[P(v-a)CO2 ] could be a useful marker to assess tissue perfusion status. Herein, we assessed the predictive values of postoperative P(v-a)CO2 measurements for mortality in critically ill patients after major surgery. The correlation between P(v-a)CO2 values and other conventional parameters of patient prognosis was also evaluated. METHODS: Patients admitted to the intensive care unit(ICU) after abdominal surgery were enrolled...
January 17, 2024: Asian Journal of Surgery
https://read.qxmd.com/read/38222708/evaluating-the-factors-affecting-clinical-outcomes-in-critically-ill-covid-19-unvaccinated-patients-admitted-to-the-intensive-care-unit-in-a-lower-middle-income-country
#29
JOURNAL ARTICLE
Fatemeh Heydari, Elahe Karimpour-Razkenari, Parnian Azadtarigheh, Alireza Vahdatinia, Ali Salahshoor, Abbas Alipour, Mahmood Moosazadeh, Afshin Gholipour Baradari, Mahila Monajati, Fahimeh Naderi-Behdani
BACKGROUND: COVID-19, the most destructive pandemic of this century, caused the highest mortality rate among ICU patients. The evaluation of these patients is insufficient in lower-middle-income countries with limited resources during pandemics. As a result, our primary goal was to examine the characteristics of patients at baseline as well as their survival outcomes, and propose mortality predictors for identifying and managing the most vulnerable patients more effectively and quickly...
January 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38195535/low-plasma-vitamin-d-is-associated-with-increased-28-day-mortality-and-worse-clinical-outcomes-in-critically-ill-patients
#30
JOURNAL ARTICLE
Fatemeh Sistanian, Alireza Sedaghat, Mohaddeseh Badpeyma, Majid Khadem Rezaiyan, Ahmad Bagheri Moghaddam, Golnaz Ranjbar, Mostafa Arabi, Mohammad Bagherniya, Abdolreza Norouzy
BACKGROUND & OBJECTIVE: Patients in the intensive care unit have a high prevalence of vitamin D deficiency (VDD). In the present study, clinical outcomes in the ICU were analyzed with vitamin D status. MATERIALS AND METHODS: In this prospective, multicenter study, sampling was conducted on seven ICUs in three hospitals. Within the first 24 h of ICU admission, patient's serum vitamin D levels were measured, and their disease severity was monitored using the scores of acute physiologic assessment and chronic health evaluation II (APACHE II), sequential organ failure assessment (SOFA), and the modified Nutrition Risk in Critically ill (mNUTRIC) score...
January 9, 2024: BMC Nutrition
https://read.qxmd.com/read/38188547/serum-procalcitonin-levels-are-associated-with-rhabdomyolysis-following-exertional-heatstroke-an-over-10-year-intensive-care-survey
#31
JOURNAL ARTICLE
Li Zhong, Feifei Shuai, Conglin Wang, Lipeng Han, Zhifeng Liu, Ming Wu
BACKGROUND: Heatstroke has become a common emergency event in hospitals. Procalcitonin (PCT) is used as a biomarker of infection in the emergency department (ED), but its role in rhabdomyolysis (RM) following exertional heatstroke (EHS) remains unclear. METHODS: A retrospective cohort study enrolled patients with EHS from the intensive care unit (ICU). We collected RM biomarkers, inflammation markers, critical disease scores at admission, 24 h, 48 h, and discharge, and 90-day mortality...
2024: World Journal of Emergency Medicine
https://read.qxmd.com/read/38186542/association-between-the-site-of-infection-and-mortality-analysis-in-critically-ill-surgical-patients
#32
JOURNAL ARTICLE
Waleed Bin Ghaffar, Sidra Nazir, Summiya Siddiqui, Moeed B Abdul Ghaffar, Muhammad F Khan, Asad Latif, Zahra Cheema, Sadaf Hanif, Mohammad Sohaib
Background Sepsis remains a critical global health concern, leading to a high mortality rate. Existing literature suggests a potential correlation between infection site and mortality. Mortality data from Pakistan, especially in the context of the infection site, is notably scarce. Purpose The study aimed to explore the relationship between the site of infection and clinical features in deceased septic patients in the surgical intensive care unit. Methods In this retrospective study conducted at the Aga Khan University Hospital, data from patients admitted to the surgical intensive care unit and meeting Sepsis 3 criteria over a five-year period (2016-2020) were analyzed...
December 2023: Curēus
https://read.qxmd.com/read/38180132/venetoclax-and-hypomethylating-agents-in-critically-ill-patients-with-newly-diagnosed-acute-myeloid-leukaemia
#33
JOURNAL ARTICLE
Peiqi Liang, Yan Xie, Ziyi Liu, Dong Wang, Qian Li, Yin Lu, Shengli Xue, Ying Wang, Suning Chen, Deipei Wu, Jianhong Fu
Venetoclax (VEN) in combination with hypomethylating agents (HMAs) is considered the standard of treatment for individuals with newly diagnosed acute myeloid leukaemia (AML) who are ineligible for intensive chemotherapy. We conducted a retrospective analysis that encompassed 16 critically ill patients newly diagnosed with AML who were admitted to the intensive care unit (ICU) and received the VEN and HMA regimen. Among them, 13 were primary AML, and three were MDS-transformed AML. The mean Acute Physiology and Chronic Health Evaluation II (APACHE II) score was 18...
January 5, 2024: British Journal of Haematology
https://read.qxmd.com/read/38173474/clinical-significance-of-serum-lactate-and-lactate-dehydrogenase-levels-for-disease-severity-and-clinical-outcomes-in-patients-with-colorectal-cancer-admitted-to-the-intensive-care-unit
#34
JOURNAL ARTICLE
Xin Wang, Chen Li, Ming Li, Xiongfei Zeng, Jinsong Mu, Yan Li
OBJECTIVE: Serum lactate (LA) and lactate dehydrogenase (LDH) levels have a major impact on the clinical treatment of malignant tumors and critically ill patients. Nevertheless, the assessment of disease severity in oncology patients admitted to the intensive care unit (ICU) remains incomplete when considering the serum LA and LDH levels. This study aimed to investigate the significance of serum LDH and LA levels in assessing disease severity and predicting clinical outcomes in patients with colorectal cancer (CRC) admitted to the ICU...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38171953/a-nomogram-based-on-quantitative-eeg-to-predict-the-prognosis-of-nontraumatic-coma-patients-in-the-neuro-intensive-care-unit
#35
JOURNAL ARTICLE
Ningxiang Qin, Qingqing Cao, Feng Li, Wei Wang, Xi Peng, Liang Wang
OBJECTIVE: We aimed to establish a quantitative electroencephalography-based prognostic prediction model specifically tailored for nontraumatic coma patients to guide clinical work. METHODS: This retrospective study included 126 patients with nontraumatic coma admitted to the First Affiliated Hospital of Chongqing Medical University from December 2020 to December 2022. Six in-hospital deaths were excluded. The Glasgow Outcome Scale assessed the prognosis at 3 months after discharge...
January 2, 2024: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://read.qxmd.com/read/38147124/severity-of-critical-illness-correlates-with-cd3-low-expression-on-inkt-cells-among-septic-surgical-patients
#36
JOURNAL ARTICLE
Daithi S Heffernan, Chun-Shiang Chung, Alfred Ayala
BACKGROUND: iNKT-cells are innate regulatory lymphocytes capable of directing immune and inflammatory responses to sepsis. Repeat stimulation of iNKT-cells leads to the induction of anergy with the emergence of a hyporesponsive CD3low iNKT-cell subpopulation. METHODS: iNKT-cells were isolated from critical ill surgical patients with sepsis and phenotyped for CD3 expression. This was correlated with degree of severity of illness, as denoted by APACHE-II score. RESULTS: Comparing healthy volunteers to critically ill septic patients, it was noted that increasing severity of sepsis was associated with increasing frequency of circulating CD3low -iNKT-cell populations...
December 26, 2023: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38137551/clinical-and-microbiological-impact-of-implementing-a-decision-support-algorithm-through-microbiologic-rapid-diagnosis-in-critically-ill-patients-an-epidemiological-retrospective-pre-post-intervention-study
#37
JOURNAL ARTICLE
Alejandro Rodríguez, Frederic Gómez, Carolina Sarvisé, Cristina Gutiérrez, Montserrat Galofre Giralt, María Dolores Guerrero-Torres, Sergio Pardo-Granell, Ester Picó-Plana, Clara Benavent-Bofill, Sandra Trefler, Julen Berrueta, Laura Canadell, Laura Claverias, Erika Esteve Pitarch, Montserrat Olona, Graciano García Pardo, Xavier Teixidó, Laura Bordonado, María Teresa Sans, María Bodí
BACKGROUND: Data on the benefits of rapid microbiological testing on antimicrobial consumption (AC) and antimicrobial resistance patterns (ARPs) are scarce. We evaluated the impact of a protocol based on rapid techniques on AC and ARP in intensive care (ICU) patients. METHODS: A retrospective pre- (2018) and post-intervention (2019-2021) study was conducted in ICU patients. A rapid diagnostic algorithm was applied starting in 2019 in patients with a lower respiratory tract infection...
December 16, 2023: Biomedicines
https://read.qxmd.com/read/38115263/application-of-b-ultrasound-for-localization-and-its-impact-on-first-attempt-success-rates-of-nasogastric-tube-insertion-in-critically-ill-patients
#38
JOURNAL ARTICLE
Lijuan Gao, Xiajuan Luo, Huijie Deng, Ni Shi, Xiaohua Wen
The objective of this study is to explore the application effect of B-ultrasound positioning in assisting nasointestinal tube implantation in critically ill patients. This study is a retrospective study. In this study, 90 cases of severe patients with nasointestinal tube implantation were included. According to the different ways of nasointestinal tube insertion received by patients, 61 patients with conventional blind insertion methods were included in the blind insertion group, and 29 patients with conventional methods and B-ultrasound assisted positioning were included in the B-ultrasound positioning group...
December 15, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/38115015/gut-microbiome-dynamics-and-associations-with-mortality-in-critically-ill-patients
#39
JOURNAL ARTICLE
Tarik J Salameh, Katharine Roth, Lisa Schultz, Zhexi Ma, Anthony S Bonavia, James R Broach, Bin Hu, Judie A Howrylak
BACKGROUND: Critical illness and care within the intensive care unit (ICU) leads to profound changes in the composition of the gut microbiome. The impact of such changes on the patients and their subsequent disease course remains uncertain. We hypothesized that specific changes in the gut microbiome would be more harmful than others, leading to increased mortality in critically ill patients. METHODS: This was a prospective cohort study of critically ill adults in the ICU...
December 19, 2023: Gut Pathogens
https://read.qxmd.com/read/38105604/real-time-camera-image-guided-nasoenteric-tube-placement-in-prone-covid-19-icu-patients-a-single-center-study
#40
JOURNAL ARTICLE
Yuequn Chen, Guiqiong Wu, Chaojun Qu, Zimao Ye, Yihao Kang, Xin Tian
Background & Aims: This study aims to assess the application value of the real-time camera image-guided nasoenteric tube placement in critically ill COVID-19 patients undergoing endotracheal intubation and prone position ventilation therapy. Methods: We enrolled 116 COVID-19 patients receiving endotracheal intubation and prone position ventilation therapy in the intensive care unit (ICU). Patients were randomly divided into the real-time camera image-guided nasoenteric tube placement (n = 58) and bedside blind insertion (n = 58) groups...
December 17, 2023: Journal of Intensive Care Medicine
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