Dayane Moraes, Gabriel Brum Tristão, Chad A Rappleye, Stephanie C Ray, Fátima Ribeiro-Dias, Rodrigo Saar Gomes, Leandro do Prado Assunção, Juliano Domiraci Paccez, Rosely Maria Zancopé-Oliveira, Mirelle Garcia Silva-Bailão, Célia Maria de Almeida Soares, Alexandre Melo Bailão
During the infectious process, pathogenic microorganisms must obtain nutrients from the host in order to survive and proliferate. These nutritional sources include the metallic nutrient copper. Despite its essentiality, copper in large amounts is toxic. Host defense mechanisms use high copper poisoning as a fungicidal strategy to control infection. Transcriptional analyses showed that yeast cultured in presence of copper or inside macrophages (24 h) had elevated expression of CRP1, a fungi copper efflux pump, suggesting that H...
November 11, 2023: FEBS Journal