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copper metabolism

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https://www.readbyqxmd.com/read/28303424/inherited-disorders-of-transition-metal-metabolism-an-update
#1
REVIEW
Peter T Clayton
Elements with a biological role include six trace transition metals: manganese, iron, cobalt, copper, zinc and molybdenum. Transition metals participate in group transfer reactions such as glycosylation and phosphorylation and those that can transfer an electron by alternating between two redox states such as iron (3+/2+) and copper (2+/1+) are also very important in biological redox reactions including the reduction of molecular oxygen and the transport of oxygen. However, these trace metals are also potentially toxic, generating reactive oxygen species through Fenton chemistry...
March 16, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28303360/modulation-of-linoleic-acid-binding-properties-of-human-serum-albumin-by-divalent-metal-cations
#2
Ekaterina L Nemashkalova, Eugene A Permyakov, Sergei E Permyakov, Ekaterina A Litus
Human serum albumin (HSA) is an abundant multiligand carrier protein, linked to progression of Alzheimer's disease (AD). Blood HSA serves as a depot of amyloid β (Aβ) peptide. Aβ peptide-buffering properties of HSA depend on interaction with its ligands. Some of the ligands, namely, linoleic acid (LA), zinc and copper ions are involved into AD progression. To clarify the interplay between LA and metal ion binding to HSA, the dependence of LA binding to HSA on Zn(2+), Cu(2+), Mg(2+) and Ca(2+) levels and structural consequences of these interactions have been explored...
March 16, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28296007/copper-metallothioneins
#3
REVIEW
Jenifer Calvo, Hunmin Jung, Gabriele Meloni
Metallothioneins (MTs) are a class of low molecular weight and cysteine-rich metal binding proteins present in all the branches of the tree of life. MTs efficiently bind with high affinity several essential and toxic divalent and monovalent transition metals by forming characteristic polynuclear metal-thiolate clusters within their structure. MTs fulfil multiple biological functions related to their metal binding properties, with essential roles in both Zn(II) and Cu(I) homeostasis as well as metal detoxification...
March 13, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28293195/comparative-investigation-of-copper-tolerance-and-identification-of-putative-tolerance-related-genes-in-tardigrades
#4
Thomas L Hygum, Dannie Fobian, Maria Kamilari, Aslak Jørgensen, Morten Schiøtt, Martin Grosell, Nadja Møbjerg
Tardigrades are microscopic aquatic animals renowned for their tolerance toward extreme environmental conditions. The current study is the first to investigate their tolerance toward heavy metals and we present a novel tardigrade toxicant tolerance assay based on activity assessments as a measure of survival. Specifically, we compare tolerance toward copper in four species representing different evolutionary lineages, habitats and adaptation strategies, i.e., a marine heterotardigrade, Echiniscoides sigismundi, a limno-terrestrial heterotardigrade, Echiniscus testudo, a limno-terrestrial eutardigrade, Ramazzottius oberhaeuseri, and a marine eutardigrade, Halobiotus crispae...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28292787/extensive-copy-number-variation-in-fermentation-related-genes-among-saccharomyces-cerevisiae-wine-strains
#5
Jacob Steenwyk, Antonis Rokas
Due to the importance of Saccharomyces cerevisiae in wine-making, the genomic variation of wine yeast strains has been extensively studied. One of the major insights stemming from these studies is that wine yeast strains harbor low levels of genetic diversity in the form of single nucleotide polymorphisms (SNPs). Genomic structural variants, such as copy number (CN) variants, are another major type of variation segregating in natural populations. To test whether genetic diversity in CN variation is also low across wine yeast strains, we examined genome-wide levels of CN variation in 132 whole-genome sequences of S...
March 14, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28276010/isolation-of-functional-mitochondria-from-cultured-cells-and-mouse-tissues
#6
Jennifer Wettmarshausen, Fabiana Perocchi
Mitochondria serve as the center stage for a number of cellular processes, including energy production, apoptosis, ion homeostasis, iron and copper processing, steroid metabolism, de novo pyrimidine, and heme biosynthesis. The study of mitochondrial function often requires the purification of intact and respiratory-competent organelles. Here, we provide detailed protocols to isolate functional mitochondria from various types of mammalian cells and mouse tissues, in both crude and pure forms. We introduce the use of nitrogen cavitation for the disruption of plasma membrane and the reproducible isolation of mitochondria-enriched fractions of high yield...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28271632/the-role-of-insufficient-copper-in-lipid-synthesis-and-fatty-liver-disease
#7
REVIEW
Austin Morrell, Savannah Tallino, Lei Yu, Jason L Burkhead
The essential transition metal copper is important in lipid metabolism, redox balance, iron mobilization, and many other critical processes in eukaryotic organisms. Genetic diseases where copper homeostasis is disrupted, including Menkes disease and Wilson disease, indicate the importance of copper balance to human health. The severe consequences of insufficient copper supply are illustrated by Menkes disease, caused by mutation in the X-linked ATP7A gene encoding a protein that transports copper from intestinal epithelia into the bloodstream and across the blood-brain barrier...
March 8, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28265897/wilson-s-disease-in-china
#8
REVIEW
Juan-Juan Xie, Zhi-Ying Wu
Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism. Its incidence is higher in China than in western countries. ATP7B is the causative gene and encodes a P-type ATPase, which participates in the synthesis of holoceruloplasmin and copper excretion. Disease-causing variants of ATP7B disrupt the normal structure or function of the enzyme and cause copper deposition in multiple organs, leading to diverse clinical manifestations. Given the variety of presentations, misdiagnosis is not rare...
March 6, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28265875/the-study-of-mechanisms-of-biological-activity-of-copper-oxide-nanoparticle-cuo-in-the-test-for-seedling-roots-of-triticum-vulgare
#9
Anastasia Mickhailovna Korotkova, Svyatoslav Valeryevich Lebedev, Irina Aleksandrovna Gavrish
The rapid development of nanotechnology raises questions assessment of their impact on living objects. In the present study, we evaluated the impact of nanoparticle (NP) CuO at concentrations ranging from 0.8 to 63.5 g/l in the test on wheat seedlings Triticum vulgare during 1-72 h. In the viability test (WST-test), cells were isolated from the roots of seedlings T. vulgare, 12 h not observed increase reductase activity after 24 h decreased rate of not more than 19% compared with the control. The number of dead cells in seedlings of T...
March 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28262560/bliss-a-bioorthogonal-dual-labeling-strategy-to-unravel-lignification-dynamics-in-plants
#10
Cedric Lion, Clémence Simon, Brigitte Huss, Anne-Sophie Blervacq, Louis Tirot, Djadidi Toybou, Corentin Spriet, Christian Slomianny, Yann Guerardel, Simon Hawkins, Christophe Biot
A better in vivo understanding of lignin formation within plant cell walls will contribute to improving the valorization of plant-derived biomass. Although bioorthogonal chemistry provides a promising platform to study the lignification process, methodologies that simultaneously detect multiple chemical reporters in living organisms are still scarce. Here, we have developed an original bioorthogonal labeling imaging sequential strategy (BLISS) to visualize and analyze the incorporation of both p-hydroxyphenyl (H) and guaiacyl (G) units into lignin in vivo with a combination of strain-promoted and copper-catalyzed azide-alkyne cycloadditions...
March 16, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28260522/medicinal-and-healthical-applications-of-tinospora-cordifolia-guduchi-a-miraculous-herb-countering-various-diseases-disorders-and-potentials-as-an-immune-booster
#11
Kuldeep Dhama Dhama, Swati Sachan, Rekha Khandia, Ashok Munjal, Hafiz M N Iqbal, Shyma K Latheef, Kumaragurubaran Karthik, Hari Abdul Samad, Ruchi Tiwari, Maryam Dadar
BACKGROUND: Plants have been known as an integral part of traditional medicine because of their phytoconstituents with their miraculous substances. Tinospora cordifolia (Guduchi/Giloy) is one such plant having pharmacological functions and medicinal values due to its several constituents such as terpenes, glycosides, alkaloids, steroids and flavonoids. Thus, it has been rightly mentioned in old texts as "Amrita". OBJECTIVE: The objective of the present review is to extend the current knowledge, importance and beneficial pharmacological applications of Guduchi in humans for safeguarding various health issues...
February 28, 2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28260463/auxiliary-partial-orthotopic-living-liver-transplant-for-wilson-disease
#12
Mehmet Haberal, Aydincan Akdur, Gokhan Moray, Sedat Boyacioglu, Adnan Torgay, Gulnaz Arslan, Gulnaz Arslan, Binnaz Handan Ozdemir
Wilson disease is a genetic disease involving copper metabolism disturbances that result in copper accumulations, especially in the liver and brain. Wilson disease can be treated with pharmacologic agents, such as chelators that induce urinary excretion of copper or zinc salts that inhibit copper absorption in the digestive tract. Liver transplant is the only treatment option for Wilson disease when liver failure has occurred. In some patients, that is, in those with Child-Pugh A score, neurologic disease can be seen without hepatic failure...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28258359/concentration-of-zinc-copper-iron-calcium-and-magnesium-in-the-serum-tissues-and-urine-of-streptozotocin-induced-mild-diabetic-rat-model
#13
Tahiry Gómez, Leticia Bequer, Angel Mollineda, José L Molina, Alain Álvarez, Mayrelis Lavastida, Sonia Clapés
The present study aimed to investigate, in the streptozotocin-induced mild diabetic rat model, the zinc (Zn), copper (Cu), iron (Fe), calcium (Ca), and magnesium (Mg) concentration in serum, liver, and kidney tissues, and urine samples from adult Wistar rats treated neonatally with streptozotocin (STZ). Diabetes was induced by subcutaneous administration of streptozotocin (100 mg/Kg) in female Wistar rats of 2 days old (STZ, n = 10). Control group (CG, n = 10) received only sodium-citrate buffer. The mineral concentrations were measured by atomic absorption spectrophotometry...
March 3, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28252952/new-iminodiacetate-thiosemicarbazone-hybrids-and-their-copper-ii-complexes-are-potential-ribonucleotide-reductase-r2-inhibitors-with-high-antiproliferative-activity
#14
Mirela F Zaltariov, Marta Hammerstad, Homayon J Arabshahi, Katarina Jovanović, Klaus W Richter, Maria Cazacu, Sergiu Shova, Mihaela Balan, Niels H Andersen, Siniša Radulović, Jóhannes Reynisson, K Kristoffer Andersson, Vladimir B Arion
As ribonucleotide reductase (RNR) plays a crucial role in nucleic acid metabolism, it is an important target for anticancer therapy. The thiosemicarbazone Triapine is an efficient R2 inhibitor, which has entered ∼20 clinical trials. Thiosemicarbazones are supposed to exert their biological effects through effectively binding transition-metal ions. In this study, six iminodiacetate-thiosemicarbazones able to form transition-metal complexes, as well as six dicopper(II) complexes, were synthesized and fully characterized by analytical, spectroscopic techniques (IR, UV-vis; (1)H and (13)C NMR), electrospray ionization mass spectrometry, and X-ray diffraction...
March 2, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28252223/chronic-effects-of-copper-in-oysters-crassostrea-hongkongensis-under-different-exposure-regimes-as-shown-by-nmr-based-metabolomics
#15
Chen Cao, Wen-Xiong Wang
Traditional metal toxicity tests on organisms have mainly focused on continuous exposure at a fixed concentration. However, organisms are more likely exposed to pollutants intermittently in estuarine environments that are significantly impacted by anthropogenic activity. The present study examined whether different copper (Cu) exposure regimes at an equivalent dose can induce different metabolomics effects on the oysters. An estuarine oyster Crassostrea hongkongensis was exposed to Cu continuously or intermittently at an equal dose (time × concentration) for 6 wk...
March 2, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28246565/diphenhydramine-as-a-cause-of-drug-induced-liver-injury
#16
Yunseok Namn, Yecheskel Schneider, Isabelle H Cui, Arun Jesudian
Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the Unites States and accounts for 10% of acute hepatitis cases. We report the only known case of diphenhydramine-induced acute liver injury in the absence of concomitant medications. A 28-year-old man with history of 13/14-chromosomal translocation presented with fevers, vomiting, and jaundice. Aspartate-aminotransferase and alanine-aminotransferase levels peaked above 20,000 IU/L and 5,000 IU/L, respectively. He developed coagulopathy but without altered mental status...
2017: Case Reports in Hepatology
https://www.readbyqxmd.com/read/28239415/coupling-gene-regulatory-patterns-to-bioprocess-conditions-to-optimize-synthetic-metabolic-modules-for-improved-sesquiterpene-production-in-yeast
#17
Bingyin Peng, Manuel R Plan, Alexander Carpenter, Lars K Nielsen, Claudia E Vickers
BACKGROUND: Assembly of heterologous metabolic pathways is commonly required to generate microbial cell factories for industrial production of both commodity chemicals (including biofuels) and high-value chemicals. Promoter-mediated transcriptional regulation coordinates the expression of the individual components of these heterologous pathways. Expression patterns vary during culture as conditions change, and this can influence yeast physiology and productivity in both positive and negative ways...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28238459/linking-sources-to-early-effects-by-profiling-urine-metabolome-of-residents-living-near-oil-refineries-and-coal-fired-power-plants
#18
Chi-Hsin Sally Chen, Tzu-Hsuen Yuan, Ruei-Hao Shie, Kuen-Yuh Wu, Chang-Chuan Chan
BACKGROUND: This study aims at identifying metabolic changes linking external exposure to industrial air toxics with oxidative stress biomarkers. METHODS: We classified 252 study subjects as 111 high vs. 141 low exposure subjects by the distance from their homes to the two main emission sources, oil refineries and coal-fired power plants. We estimated individual's external exposure to heavy metals and polycyclic aromatic hydrocarbons (PAHs) by dispersion and kriging models, respectively...
February 23, 2017: Environment International
https://www.readbyqxmd.com/read/28238184/biodegradation-of-pentachloronitrobenzene-by-cupriavidus-sp-yns-85-and-its-potential-for-remediation-of-contaminated-soils
#19
Ying Teng, Xiaomi Wang, Ye Zhu, Wei Chen, Peter Christie, Zhengao Li, Yongming Luo
Pentachloronitrobenzene (PCNB) is a toxic chlorinated nitroaromatic compound. However, only a few bacteria have been reported to be able to utilize PCNB. In the present study, one pentachloronitrobenzene (PCNB)-degrading bacterium, Cupriavidus sp. YNS-85, was isolated from a contaminated Panax notoginseng plantation. The strain co-metabolized 200 mg L(-1) PCNB in aqueous solution with a removal rate of 73.8% after 5 days. The bacterium also degraded PCNB effectively under acid conditions (pH 4-6) and showed resistance to toxic trace elements (arsenic, copper, and cadmium)...
February 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28236764/the-response-of-isidorella-newcombi-to-copper-exposure-using-an-integrated-biological-framework-to-interpret-transcriptomic-responses-from-rna-seq-analysis
#20
Rodney P Ubrihien, Tariq Ezaz, Anne M Taylor, Mark M Stevens, Frank Krikowa, Simon Foster, William A Maher
This study describes the transcriptomic response of the Australian endemic freshwater gastropod Isidorella newcombi exposed to 80±1μg/L of copper for 3days. Analysis of copper tissue concentration, lysosomal membrane destabilisation and RNA-seq were conducted. Copper tissue concentrations confirmed that copper was bioaccumulated by the snails. Increased lysosomal membrane destabilisation in the copper-exposed snails indicated that the snails were stressed as a result of the exposure. Both copper tissue concentrations and lysosomal destabilisation were significantly greater in snails exposed to copper...
April 2017: Aquatic Toxicology
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