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copper metabolism

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https://www.readbyqxmd.com/read/28926697/copper-inhibits-the-alkb-family-dna-repair-enzymes-under-wilson-s-disease-condition
#1
Ke Bian, Fangyi Chen, Zachary T Humulock, Qi Tang, Deyu Li
Disturbed metabolism of copper ions can cause diseases, such as Wilson's disease (WD). In this work, we investigated the inhibi-tory effect of Cu(II) ion on the AlkB family DNA repair enzymes in vitro, which are members of the Fe(II)/alpha-ketoglutarate-dependent dioxygenase and include human ALKBH2, ALKBH3, and E. coli AlkB proteins. None of the three proteins were significantly inhibited under normal cellular copper concentrations. But under WD related condition, we observed the activities of all three enzymes were strongly suppressed (from 95...
September 19, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28889269/copper-and-alzheimer-s-disease
#2
Zoe K Mathys, Anthony R White
Alzheimer's disease (AD) is the most common form of adult neurode-generation and is characterised by progressive loss of cognitive function leading to death. The neuropathological hallmarks include extracellular amyloid plaque accumulation in affected regions of the brain, formation of intraneuronal neurofibrillary tangles, chronic neuroinflammation, oxidative stress, and abnormal biometal homeostasis. Of the latter, major changes in copper (Cu) levels and localisation have been identified in AD brain, with accumulation of Cu in amyloid deposits, together with deficiency of Cu in some brain regions...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28887459/the-unexpected-role-of-bioaerosols-in-the-oxidative-potential-of-pm
#3
A Samake, G Uzu, J M F Martins, A Calas, E Vince, S Parat, J L Jaffrezo
Bioaerosols represent up to 15-25% of PM by mass, but there is currently no assessment of their impact on Oxidative Potential (OP), or capacity of particulate matter (PM) to produce damaging oxidative reactions in the human lungs. Here, the OP of selected bioaerosols (bacteria cells vs fungal spores) was assessed through the cell-free DTT assay. Results show that bioaerosols induce Reactive Oxygen Species (ROS) production, varying along the microorganism type, species, and concentration. Fungal spores show up to 10 times more ROS generation than bacterial cells...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28883881/zinc-and-copper-metabolism-and-risk-of-autism-a-reply-to-sayehmiri-et-al
#4
Keith Fluegge Ba
OBJECTIVE: Sayehmiri et al. recently conducted a meta-analysis to explore the relationship between zinc and copper metabolism and autism spectrum disorders (ASD). Recent reports have elucidated a full behavioral profile of mice exposed to prenatal zinc deficiency and documented a phenotype similar to that found in autism spectrum disorders (ASD). These studies suggest that significant alterations in Zn metabolism may be an important nutritional component in the development of ASD. MATERIALS & METHODS: The idea that prenatal zinc deficiency may be to blame is cursorily challenged...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/28878286/proteomic-analysis-on-roots-of-oenothera-glazioviana-under-copper-stress-conditions
#5
Chong Wang, Jie Wang, Xiao Wang, Yan Xia, Chen Chen, Zhenguo Shen, Yahua Chen
Proteomic studies were performed to identify proteins involved in the response of Oenothera glazioviana seedlings under Cu stress. Exposure of 28-d-old seedlings to 50 μM CuSO4 for 3 d led to inhibition of shoot and root growth as well as a considerable increase in the level of lipid peroxidation in the roots. Cu absorbed by O. glazioviana accumulated more easily in the root than in the shoot. Label-free proteomic analysis indicated 58 differentially abundant proteins (DAPs) of the total 3,149 proteins in the roots of O...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877212/selenium-deficiency-induced-alterations-in-ion-profiles-in-chicken-muscle
#6
Haidong Yao, Xia Zhao, Ruifeng Fan, Hamid Sattar, Jinxin Zhao, Wenchao Zhao, Ziwei Zhang, Yufeng Li, Shiwen Xu
Ion homeostasis plays important roles in development of metabolic diseases. In the present study, we examined the contents and distributions of 25 ions in chicken muscles following treatment with selenium (Se) deficiency for 25 days. The results revealed that in chicken muscles, the top ranked microelements were silicon (Si), iron (Fe), zinc (Zn), aluminum (Al), copper (Cu) and boron (B), showing low contents that varied from 292.89 ppb to 100.27 ppm. After Se deficiency treatment, essential microelements [Cu, chromium (Cr), vanadium (V) and manganese (Mn)], and toxic microelements [cadmium (Cd) and mercury (Hg)] became more concentrated (P < 0...
2017: PloS One
https://www.readbyqxmd.com/read/28868059/integrating-early-transcriptomic-responses-to-rhizotoxins-in-rice-oryza-sativa-l-reveals-key-regulators-and-a-potential-early-biomarker-of-cadmium-toxicity
#7
Li-Yao Huang, Chung-Wen Lin, Ruey-Hua Lee, Chih-Yun Chiang, Yung-Chuan Wang, Ching-Han Chang, Hao-Jen Huang
As sessile organisms, plants were constantly challenged with biotic and abiotic stresses. Transcriptional activation of stress-responsive genes is a crucial part of the plant adaptation to environmental changes. Here, early response of rice root to eight rhizotoxic stressors: arsenate, copper, cadmium, mercury, chromate, vanadate, ferulic acid and juglone, was analyzed using published microarray data. There were 539 general stress response (GSR) genes up-regulated under all eight treatments, including genes related to carbohydrate metabolism, phytohormone balance, and cell wall structure...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28867395/nanoformulated-copper-zinc-superoxide-dismutase-exerts-differential-effects-on-glucose-vs-lipid-homeostasis-depending-on-the-diet-composition-possibly-via-altered-ampk-signaling
#8
Gopalakrishnan Natarajan, Curtis Perriotte-Olson, Fatema Bhinderwala, Robert Powers, Cyrus V Desouza, Geoffrey A Talmon, Jiang Yuhang, Matthew C Zimmerman, Alexander V Kabanov, Viswanathan Saraswathi
Evidence suggests that superoxide dismutase 1 (SOD1) promotes glucose vs lipid metabolism depending on the diet type. We recently reported that nanoformulated SOD1 (Nano) improved lipid metabolism without altering glucose homeostasis in high-fat (HF) diet-fed mice. Here, we sought to determine the effects and potential mechanisms of Nano in modulating glucose and lipid homeostasis in mice fed a normal chow diet (CD) vs HF diet. Mice were fed a CD or a HF diet (45%) for 10 wk and injected with Nano once every 2 days for 15 days...
October 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28860760/copper-nanoparticle-induced-ovarian-injury-follicular-atresia-apoptosis-and-gene-expression-alterations-in-female-rats
#9
Jing Yang, Shifu Hu, Meng Rao, Lixia Hu, Hui Lei, Yanqing Wu, Yingying Wang, Dandan Ke, Wei Xia, Chang-Hong Zhu
Numerous studies have reported the accumulation of copper nanoparticles (Cu NPs) in organs and the corresponding damage, although whether Cu NPs can be translocated to the ovaries and their ovarian toxicity are still unknown. In this study, three groups of female rats were injected with 3.12, 6.25, or 12.5 mg/kg Cu NPs for 14 consecutive days. The pathological changes, hormone levels, apoptosis and apoptotic proteins, oxidative stress, and gene expression characteristics in the ovaries were then investigated...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28859232/pregnancy-in-wilson-disease-management-and-outcome
#10
Jan Pfeiffenberger, Sandra Beinhardt, Daniel N Gotthardt, Nicola Haag, Clarissa Freissmuth, Ulrike Reuner, Annika Gauss, Wolfgang Stremmel, Michael L Schilsky, Peter Ferenci, Karl Heinz Weiss
Introduction Wilson disease (WD) is a rare inherited disorder of copper metabolism causing toxic hepatic and neural copper accumulation. Clinical symptoms vary widely, from asymptomatic disease to acute liver failure or chronic liver disease without or with neuropsychiatric symptoms. Continuation of specific medical treatment for WD is recommended during pregnancy, but reports of pregnancy outcomes in WD patients are sparse. Patients and methods In a retrospective, multicenter study, 282 pregnancies in 136 WD patients were reviewed...
August 31, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28852304/wilson-s-disease-prospective-developments-towards-new-therapies
#11
EDITORIAL
Giusy Ranucci, Roman Polishchuck, Raffaele Iorio
Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism, caused by mutations in the ATP7B gene. A clear demand for novel WD treatment strategies has emerged. Although therapies using zinc salts and copper chelators can effectively cure WD, these drugs exhibit limitations in a substantial pool of WD patients who develop intolerance and/or severe side effects. Several lines of research have indicated intriguing potential for novel strategies and targets for development of new therapies. Here, we review these new approaches, which comprise correction of ATP7B mutants and discovery of new compounds that circumvent ATP7B-deficiency, as well as cell and gene therapies...
August 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28852006/a-rapid-evaluation-of-acute-hydrogen-sulfide-poisoning-in-blood-based-on-dna-cu-ag-nanocluster-fluorescence-probe
#12
Yanjun Ding, Xingmei Li, Ceng Chen, Jiang Ling, Weichen Li, Yadong Guo, Jie Yan, Lagabaiyla Zha, Jifeng Cai
Hydrogen sulfide (H2S) is a highly toxic gas as a cause of inhalational death. Accurate detection of H2S poisoning concentration is valuable and vital for forensic workers to estimate the cause of death. But so far, it is no uniform and reliable standard method to measure sulfide concentrations in H2S poisoning blood for forensic identification. This study introduces a fluorescence sensing technique into forensic research, in which a DNA-templated copper/silver nanocluster (DNA-Cu/AgNCs) fluorescence probe has been proposed to selective detection of S(2-)...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28831604/distinct-taxonomic-and-functional-composition-of-soil-microbiomes-along-the-gradient-forest-restinga-mangrove-in-southeastern-brazil
#13
Lucas William Mendes, Siu Mui Tsai
Soil microorganisms play crucial roles in ecosystem functioning, and the central goal in microbial ecology studies is to elucidate which factors shape community structure. A better understanding of the relationship between microbial diversity, functions and environmental parameters would increase our ability to set conservation priorities. Here, the bacterial and archaeal community structure in Atlantic Forest, restinga and mangrove soils was described and compared based on shotgun metagenomics. We hypothesized that each distinct site would harbor a distinct taxonomic and functional soil community, which is influenced by environmental parameters...
August 22, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28820536/atp7a-and-atp7b-regulate-copper-homeostasis-in-developing-male-germ-cells-in-mice
#14
Mateusz Ogórek, Małgorzata Lenartowicz, Rafał Starzyński, Aneta Jończy, Robert Staroń, Andrzej Doniec, Wojciech Krzeptowski, Aleksandra Bednarz, Olga Pierzchała, Paweł Lipiński, Zenon Rajfur, Zbigniew Baster, Patrycja Gibas-Tybur, Paweł Grzmil
The maintenance of copper homeostasis is critical for all cells. As learned from mice with disturbed copper metabolism, this trace element is also important for spermatogenesis. The experiments conducted in yeasts have demonstrated that appropriate copper level must be preserved to enable meiosis progression; however, increased copper level is toxic for cells. This study aims to analyze the expression profile of Atp7a and Atp7b and other genes encoding copper-related proteins during spermatogenesis in mice...
September 20, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28818407/effects-of-copper-oxide-nanoparticles-and-copper-ions-to-zebrafish-danio-rerio-cells-embryos-and-fry
#15
Amalie Thit, Lars M Skjolding, Henriette Selck, Joachim Sturve
The use of engineered metal nanoparticles (NPs) is continuously increasing and so is the need for information regarding their toxicity. This study compares the toxicity of CuO NPs with ionic Cu in three zebrafish model systems; zebrafish hepatoma cell line (ZFL), fish embryo toxicity test (FET) and fry locomotion. In the ZFL tests, no significant cytotoxicity (cell death, decreased metabolic or cell membrane integrity) was detected for either treatment, though both significantly affected reactive oxygen species (ROS) production...
August 15, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28817263/responses-of-periphyton-to-fe2o3-nanoparticles-a-physiological-and-ecological-basis-for-defending-nanotoxicity
#16
Jun Tang, Ningyuan Zhu, Yan Zhu, Junzhuo Liu, Chenxi Wu, Philip Kerr, Yonghong Wu, Paul K S Lam
The toxic effects of nanoparticles on individual organisms have been widely investigated, while few studies have investigated the effects of nanoparticles on ubiquitous multicommunity microbial aggregates. Here, periphyton as a model of microbial aggregates, was employed to investigate the responses of microbial aggregates exposed continuously to Fe2O3 nanoparticles (5.0 mg L(-1)) for 30 days. The exposure to Fe2O3 nanoparticles results in the chlorophyll (a, b, and c) contents of periphyton increasing and the total antioxidant capacity decreasing...
August 30, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28811697/role-of-iron-and-copper-in-the-pathogenesis-of-parkinson-s-disease
#17
Mohit Kumar Gangania, Jyoti Batra, Suman Kushwaha, Rachna Agarwal
Parkinson's disease (PD) is an old age disorder of basal ganglia which involves oligomerization of α-synuclein protein and formation of intercellular inclusions known as "Lewy bodies" in substantia nigra and caudate nuclei in brain which is progressive in nature. It is second most prevalent neurodegenerative disorder characterized by tremor at rest, muscle rigidity, slowness of movement (bradykinesia, akinesia), and changes in posture (instability). Both excess and deficiency in levels of transition metals (especially iron, copper) can be detrimental to the central nervous system...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28810615/detecting-serum-and-urine-metabolic-profile-changes-of-ccl4-liver-fibrosis-in-rats-at-12-weeks-based-on-gas-chromatography-mass-spectrometry
#18
Jiarong Gao, Xiu-Juan Qin, Hui Jiang, Jin-Feng Chen, Ting Wang, Ting Zhang, Shuang-Zhi Xu, Jun-Mei Song
Liver fibrosis is caused by liver injury induced by a number of chronic liver diseases, including schistosome infection, hepatitis infection, metabolic disease, alcoholism and cholestasis. The tissue damage occurring after injury or inflammation of the liver is a reversible lesion; however, liver fibrosis has become a worldwide problem and poses a threat to human health. The development of an effective drug for the prevention and treatment of liver fibrosis is ongoing and uses information from different occurrences of liver fibrosis...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28805705/changes-of-bone-related-minerals-during-denosumab-administration-in-post-menopausal-osteoporotic-patients
#19
Takako Suzuki, Yukio Nakamura, Hiroyuki Kato
OBJECTIVES: This retrospective study included 21 patients with primary osteoporosis who were treated with the anti-resorption drug, denosumab. To date, there has been no detailed report on the changes of bone-related minerals after anti-resorption drug therapy. METHODS: Twenty-one post-menopausal females were retrospectively enrolled. Serum zinc (Zn), magnesium (Mg), iron (Fe), copper (Cu), grip strength, and estimated glomerular filtration rate (eGFR) were examined at one week and 1, 2, 4, 6, 8, 10, and 12 months...
August 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28794411/dextran-catechin-inhibits-angiogenesis-by-disrupting-copper-homeostasis-in-endothelial-cells
#20
Eugene M H Yee, Miriam B Brandl, Eddy Pasquier, Giuseppe Cirillo, Kathleen Kimpton, Maria Kavallaris, Naresh Kumar, Orazio Vittorio
Formation of blood vessels, or angiogenesis, is crucial to cancer progression. Thus, inhibiting angiogenesis can limit the growth and spread of tumors. The natural polyphenol catechin has moderate anti-tumor activity and interacts with copper, which is essential for angiogenesis. Catechin is easily metabolized in the body and this limits its clinical application. We have recently shown that conjugation of catechin with dextran (Dextran-Catechin) improves its serum stability, and exhibits potent anti-tumor activity against neuroblastoma by targeting copper homeostasis...
August 9, 2017: Scientific Reports
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