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Lele Guo, Wen Liu, Tingting Lu, Wenjie Guo, Jian Gao, Qiong Luo, Xuefeng Wu, Yang Sun, Xudong Wu, Yan Shen, Qiang Xu
Treatment of systemic lupus erythematosus (SLE), a chronic inflammatory disease, involves the long-term use of immunosuppressive agents with significant side effects. New therapeutic approaches are being explored to find better treatment possibilities. In this study, age-matched female MRL/lpr mice were treated orally with a natural flavonoid astilbin. Astilbin administration started either at week 8 or week 12 of age though week 20. In the early treatment regimen, the treatment with astilbin reduced splenomegaly/lymphomegaly, autoantibody production and ameliorated lupus nephritis...
2015: PloS One
Mehtat Unlu, Saba Kiremitci, Arzu Ensari, Yasemin Ozluk, Isin Kilicaslan, Binnaz Handan Ozdemir, Deniz Ates, Dilek Ertoy Baydar, Ipek Isik Gonul, Leyla Memis, Banu Sarsik, Sait Sen, Bahar Akkaya, Diclehan Orhan, Gulfiliz Gonlusen, Hulya Ellidokuz, Sibel Ada, Caner Cavdar, Tulin Akagun, Sevil Kamali, Kenan Aksu, Veli Yazisiz, Saime Paydas, Alper Soylu, Sulen Sarioglu
The prognostic value of the type and extent of extracapillary proliferation (ECP) in pauci-immune necrotizing crescentic glomerulonephitis (PIGN) was evaluated in this study. In 141 PIGN cases, all glomeruli with ECP were grouped according to type (cellular, fibrocellular and fibrous) and extent of the lesions in Bowman's space; (segmental, semicircumferential and circumferential, which might be termed full moon-FM). Cases with cellular and fibrous lesions involving ≥ 50% of glomeruli with ECP were classified as cellular and fibrous groups, respectively, while the remaining cases were classified as fibrocellular...
February 15, 2013: Pathology, Research and Practice
Antonio Alberto Lopes
This review presents data on end-stage renal disease (ESRD) due to diabetes (ESRD-DM) from populations of several racial/ethnic groups and regions; it also identifies factors that may explain differences in risk of ESRD-DM among these groups. Diabetes is a major cause of ESRD in several developed countries, including the United States, England, and Australia. However, in these countries, the incidence is much higher for some groups, such as Blacks and Native Americans in the United States, Blacks and Indo-Asians in England, and indigenous populations in Australia...
2009: Ethnicity & Disease
Xiao-xia Du, Hong Liu, You-Ming Peng
OBJECTIVE: To investigate the main causes of chronic renal failure (CRF) and the differences in how subpopulation is affected by these causes, and to determine the morbidity of anemia and hypertension, and the relation between age and gender in CRF patients. METHODS: We chose 1137 inpatients diagnosed as CRF in the Department of Nephropathy of 2nd Xiangya Hospital of Center South University from January 1996 to March 2002. We collected the information on name, gender, age, admission number, diagnosis, blood pressure, blood routine, renal function, and creatinine clearance rate...
December 2003: Hunan Yi Ke da Xue Xue Bao, Hunan Yike Daxue Xuebao, Bulletin of Hunan Medical University
Kenichi Kano, Yumi Yamada, Yuhya Sato, Osamu Arisaka, Yuko Ono, Yoshihiko Ueda
Renal involvement is rare in chronic active Epstein-Barr virus (EBV) infection. We report an 11-year-old girl who had focal mesangial proliferative glomerulonephritis with cellular crescents and renal tubular atrophy with foam cells in the lumen at the time of the first admission. However, the patient was not diagnosed with chronic active EBV infection until the third admission, 18 months later, because she did not exhibit typical clinical manifestations of infectious mononucleosis, i.e., fever, lymphadenopathy, hepatomegaly, or increased atypical lymphocytes...
January 2005: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
R Alvarez Navascués, Z Bastardo, M Fernández Díaz, J Guerediaga, L Quiñones, J Pinto
Loratadine is a second generation histamine H1 receptor antagonist, that has high potency antiallergic properties and is associated with low adverse effects compared with other antihistamines. Acute interstitial nephritis is a cause of acute renal failure that is most often induced by drugs or, less frequently, infection or sarcoidosis. Although the number of drugs associated with acute intersticial nephritis is too large, the antihistaminic loratadine have never been reported before. We report a case of an interstitial nephritis with acute renal failure that suggesting hypersensitivity reaction in a 77 old man who had received loratadine (10 mg/day) during ten days before his assessment to our hospital by disseminated pruritic syndrome...
July 2003: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
V Habul, M Tabakovic, E Mesic
INTRODUCTION: The aim of this study was to analyse outcome of new ESRD patients on haemodialysis. METHODS: We analysed nember, demographic data, renal disease and mortality of new ESRD patients on haemodialysis (HD) in 16-months period. RESULTS: We dialysed for the first time 74 patents with ESRD, 37 female (50%) and 37 male, average age 55.55 +/- 13.57 yrs. There were 3 patients younger than 30 yrs, 51 between 31-65 and 20 were older than 65 yrs...
2001: Medicinski Arhiv
H Kato, N Adachi, S Iwanaga, K Abe, K Takada, T Kimura, S Sakakibara
Kallikrein in human urine was measured using a fluorogenic peptide substrate, proly-phenyl-alanyl-arginine-4-methylcoumaryl-7-amide (Pro-Phe-Arg-MCA). Using 20 microliters of normal urine, kallikrein activity was quantitatively assayed by incubation with a final concentration of 10(-4) M Pro-Phe-Arg-MCA at 37 degrees C for 90 min. The reaction was terminated by adding 50 units of Trasylolr or 20 microliters of 10% acetic acid. Using this method, kallikrein activity was measured in urine from normal subjects and patients with glomerulonephitis and Bartter's syndrome...
April 1980: Journal of Biochemistry
A D Petrushina, V I Krylov, V A Zhmurov, G V Moreva
A study was made of the effect of vegetable fats on lipid metabolism and free radical oxidation, phospholipase activity and antioxidant content in 43 children suffering from chronic glomerulonephritis. After intake of a vegetative fat in a dose of 2 g/kg bw for 7 days the sick children demonstrated a significant rise in the level of total lipids in red cells and in their excretion with urine. This was in a good agreement with an increase in phospholipase activity in blood and diminution of lipid peroxides in red cell membranes...
July 1983: Voprosy Pitaniia
C Sapin, E Druet, P Druet
Anti-glomerular basement membrane (GBM) antibodies were induced in the Brown-Norway rat by mercuric chloride. The existence of anti-GBM antibodies was suspected because of the immunofluorescent linear pattern. It was proved because eluted antibodies from kidneys and circulating IgG had an anti-glomerular basement membrane activity. A glomerular basement membrane antigen modified by HgCl2 is probably responsible for the appearance of such antibodies. The previous demonstration of the occurrence of an immun complex type glomerulonephitis, in outbred Wistar rats, under the same experimental conditions, suggests the existence of a genetic control for this type of immune response...
April 1977: Clinical and Experimental Immunology
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