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left atrial function

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https://www.readbyqxmd.com/read/28534690/decreased-left-atrial-myocardial-strain-in-patients-with-suboptimal-blood-pressure-control
#1
Xiao-Jing Chen, Chen Chen, Yu-Jia Liang, Xi-Lian Gao, Jing Jiang, Yu Kang, Yu-Cheng Chen, Qing Zhang, Zhi Zeng
BACKGROUND: Suboptimal blood pressure (BP) control is commonly observed in patients receiving antihypertensive agents, but the relationship between uncontrolled BP and left atrial (LA) impairment remains unknown. METHODS: This study enrolled 279 hypertensive patients who had been medicated, as well as 85 matched normal controls. The BP of systolic <140 mmHg and diastolic<90 mmHg was defined as optimal (HT1 group, n=146), otherwise as suboptimal BP control (HT2 group, n = 133)...
May 23, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28532781/usefulness-of-left-atrial-emptying-fraction-to-predict-ventricular-arrhythmias-in-patients-with-implantable-cardioverter-defibrillators
#2
Mischa T Rijnierse, Mehran Kamali Sadeghian, Sophie Schuurmans Stekhoven, P Stefan Biesbroek, Anne-Lotte C van der Lingen, Peter M van de Ven, Albert C van Rossum, Robin Nijveldt, Cornelis P Allaart
Impaired left atrial emptying fraction (LAEF) is an important predictor of mortality in patients with heart failure. As it may reflect increased LV wall stress, it might predict ventricular arrhythmia (VA) specifically. This study evaluated the predictive value of LAEF assessed with cardiovascular magnetic resonance (CMR) imaging with respect to appropriate device therapy (ADT) for VA and compared its role with CMR assessed scar size and other risk factors. In total, 229 patients (68% male, 63 ± 10 years, 61% ischemic cardiomyopathy) with LV ejection fraction ≤35% who underwent CMR and implantable cardioverter defibrillator (ICD) implantation for primary prevention in 2005 to 2012 were included...
April 27, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28532772/echocardiographic-predictors-for-worsening-of-six-minute-walk-distances-in-patients-with-systemic-sclerosis-scleroderma
#3
Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijo, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata
Change in 6-minute walk distance (6MWD) has been used as a clinical marker in pulmonary hypertension. Determinants and worsening of 6MWD remain a matter of debate because nonpulmonary factors have an impact on the 6MWD. We hypothesized that future reduction of 6MWD in patients with systemic sclerosis (SSc) was more closely associated with cardiac dysfunction. We prospectively performed standard clinical and echocardiographic evaluations in SSc patients with the 6-minute walk test at enrollment. Features associated with the 6MWD were sought in a multiple linear regression analysis and compared using standardized β...
April 26, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28528995/the-usefulness-of-global-left-atrial-strain-for-predicting-atrial-fibrillation-recurrence-after-catheter-ablation-in-patients-with-persistent-and-paroxysmal-atrial-fibrillation
#4
Xin-Xin Ma, Yue-Li Zhang, Bing Hu, Meng-Ruo Zhu, Wen-Jun Jiang, Man Wang, Dong-Yan Zheng, Xiao-Pei Xue
BACKGROUND: Given the potential complications of atrial fibrillation (AF) recurrence after ablation, better predictors of the effectiveness of the procedure are necessary to guide patient selection. AIM: This prospective study was conducted to evaluate the clinical relevance of global left atrial longitudinal strain (GLAS) and AF recurrence after catheter ablation. METHODS: In 115 consecutive patients with AF (persistent, n=62; paroxysmal, n=53), transthoracic echocardiography was performed before catheter ablation to assess baseline left atrial mechanical function using speckle tracking echocardiography (STE)...
May 18, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28528161/functional-implication-of-mitral-annular-disjunction-in-mitral-valve-prolapse-a-quantitative-dynamic-3d-echocardiographic%C3%A2-study
#5
Alex Pui-Wai Lee, Chun-Na Jin, Yiting Fan, Randolph H L Wong, Malcolm J Underwood, Song Wan
OBJECTIVES: This study aimed to assess the hypothesis that mitral annular disjunction (MAD) is associated with abnormal annular dynamics due to decoupling of annular-ventricular function. BACKGROUND: MAD, defined as a separation between the atrial wall-mitral valve (MV) junction and left ventricular (LV) attachment, is a structural abnormality occurring in MV prolapse (MVP). Few data exist on the 3-dimensional (3D) geometry of MAD and its functional implication...
May 11, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28527865/mechanism-of-atrial-functional-mitral-regurgitation-in-patients-with-atrial-fibrillation-a-study-using-three-dimensional-transesophageal-echocardiography
#6
Kazato Ito, Yukio Abe, Yosuke Takahashi, Yoshihisa Shimada, Hitoshi Fukumoto, Yoshiki Matsumura, Takahiko Naruko, Toshihiko Shibata, Minoru Yoshiyama, Junichi Yoshikawa
BACKGROUND: Functional mitral regurgitation (MR) can occur in patients with atrial fibrillation (AF) despite having preserved left ventricular (LV) systolic function. This MR is known as atrial functional MR. The aim of this study was to clarify the mechanism of atrial functional MR using real-time three-dimensional transesophageal echocardiography (3DTEE). METHODS: Sixty patients underwent transthoracic echocardiography and 3DTEE: 16 patients with AF and significant non-organic MR and preserved LV ejection fraction (>50%) constituted the AF-MR group, 20 patients with AF and no significant MR formed the AF-NSMR group, and 24 normal subjects comprised the control group...
May 17, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28526353/stretch-activated-two-pore-domain-k2p-potassium-channels-in-the-heart-focus-on-atrial-fibrillation-and-heart-failure
#7
REVIEW
Constanze Schmidt, Felix Wiedmann, Stefan M Kallenberger, Antonius Ratte, Jan S Schulte, Beatrix Scholz, Frank Ulrich Müller, Niels Voigt, Maria-Patapia Zafeiriou, Joachim R Ehrlich, Ursula Tochtermann, Gábor Veres, Arjang Ruhparwar, Matthias Karck, Hugo A Katus, Dierk Thomas
Two-pore-domain potassium (K2P) channels modulate cellular excitability. The significance of stretch-activated cardiac K2P channels (K2P2.1, TREK-1, KCNK2; K2P4.1, TRAAK, KCNK4; K2P10.1, TREK-2, KCNK10) in heart disease has not been elucidated in detail. The aim of this work was to assess expression and remodeling of mechanosensitive K2P channels in atrial fibrillation (AF) and heart failure (HF) patients in comparison to murine models. Cardiac K2P channel levels were quantified in atrial (A) and ventricular (V) tissue obtained from patients undergoing open heart surgery...
May 16, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28523471/quantification-of-left-atrial-volume-and-phasic-function-using-cardiovascular-magnetic-resonance-imaging-comparison-of-biplane-area-length-method-and-simpson-s-method
#8
Laura Kristin Wandelt, Johannes Tammo Kowallick, Andreas Schuster, Rolf Wachter, Thomas Stümpfig, Christina Unterberg-Buchwald, Michael Steinmetz, Christian Oliver Ritter, Joachim Lotz, Wieland Staab
Left atrial (LA) enlargement and dysfunction are markers of chronic diastolic dysfunction and an important predictor of adverse cardiovascular and cerebrovascular outcomes. Accordingly, accurate quantification of left atrial volume (LAV) and function is needed. In routine clinical cardiovascular magnetic resonance (CMR) imaging the biplane area-length method (Bi-ALM) is frequently applied due to time-saving image acquisition and analysis. However, given the varying anatomy of the LA we hypothesized that the diagnostic accuracy of the Bi-ALM is not sufficient and that results would be different from a precise volumetric assessment of transversal multi-slice cine images using Simpson's method...
May 18, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28516504/prognostic-potential-of-midregional-pro-adrenomedullin-following-decompensation-for-systolic-heart-failure-comparison-with-cardiac-natriuretic-peptides
#9
Caroline Morbach, Almuth Marx, Mathias Kaspar, Gülmisal Güder, Susanne Brenner, Carolin Feldmann, Stefan Störk, Jörn O Vollert, Georg Ertl, Christiane E Angermann
AIMS: Whereas guidelines recommend the routine use of natriuretic peptides (NPs) in heart failure (HF) care, the clinical relevance and prognostic potential of midregional pro-adrenomedullin (MR-proADM) is less well established. We aimed to compare the prognostic potential of MR-proADM after acute decompensation for systolic HF with that of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and midregional pro-atrial NP (MR-proANP), to investigate the significance of high/rising MR-proADM, and to evaluate the incremental prognostic yield of repeat measurements...
May 17, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28515825/late-presentation-of-aortic-aneurysm-and-dissection-following-cardiac-catheterization
#10
Abimbola Shofu, G Mustafa Awan, Bassam Omar, Ghazanfar Qureshi
We report a 63-year-old female with hypertension, hyperlipidemia, and prior pacemaker insertion for atrial fibrillation with symptomatic bradycardia, who was admitted with substernal chest pressure and diaphoresis. Her electrocardiogram revealed atrial fibrillation with demand ventricular pacing and her cardiac biomarkers were negative for acute coronary syndrome. Echocardiogram revealed normal left ventricular systolic function and normal aortic root diameter. Coronary angiography revealed 60-70% obtuse marginal lesion, otherwise mild disease...
April 2017: Cardiology Research
https://www.readbyqxmd.com/read/28515003/reverse-atrial-electrical-remodeling-induced-by-cardiac-resynchronization-therapy
#11
Bryce Alexander, Fariha Sadiq, Kousha Azimi, Benedict Glover, Pavel Antiperovitch, Wilma M Hopman, Zardasht Jaff, Adrian Baranchuk
PURPOSE: Cardiac resynchronization therapy (CRT) has been shown to improve left atrial function; however the effect on reverse electrical remodeling has been poorly evaluated. We hypothesized that CRT might induce reverse atrial electrical remodeling manifesting in the surface ECG as a shortening in P-wave duration. METHODS: Patients with CRT and more than 92% biventricular pacing at minimum follow-up of 1 year were included in the analysis. Those with prior history of atrial fibrillation (AF) were excluded...
April 28, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28513231/left-atrial-mechanical-function-and-stiffness-in-patients-with-nondipper-hypertension-a-speckle-tracking-study
#12
Mehmet Demir, İbrahim Aktaş, Ahmet Yıldırım
BACKGROUND: Nondipper hypertension is associated with increased cardiovascular morbidity and mortality. Speckle tracking echocardiography is a novel and promising tool for detecting early changes in left atrial (LA) myocardial dysfunction. Our aim was to evaluate the LA mechanical function and stiffness in nondipper hypertensive patients by two-dimensional speckle tracking echocardiography strain parameters. METHOD: This study included 80 hypertensive patients. Hypertensive patients were divided into two groups: 50 dipper patients (29 male, mean age 51...
May 17, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28513114/when-cardioversion-may-be-complicated
#13
Marina Leitman, Vladimir Tyomkin, Eli Peleg, Therese Fuchs, Ziad Gabara, Zvi Vered
BACKGROUND: In recent years cardioversion of atrial fibrillation has become a routine procedure, enabling symptomatic functional improvement in most cases. However, some patients develop complications after cardioversion. Identifying these individuals is an important step toward improving patient outcome. OBJECTIVES: To characterize those patients who may not benefit from cardioversion or who may develop complications following cardioversion. METHODS: We retrospectively analyzed 186 episodes of cardioversion in 163 patients with atrial fibrillation who were admitted to our cardiology department between 2008 and 2013 based on their clinical and echocardiographic data...
May 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28511801/intergenerational-differences-in-the-effects-of-transcatheter-closure-of-atrial-septal-defects-on-cardiac-function
#14
Hideki Tashiro, Kenji Suda, Motofumi Iemura, Youzou Teramachi
BACKGROUND: Little is known regarding intergenerational differences in the effects of atrial sepal defect (ASD) closure on the left heart. We therefore analyzed age-related serial changes in the left heart following ASD closure. METHODS: We studied 50 patients with an isolated ASD who underwent successful transcatheter closure using Amplatzer septal occluders (St. Jude Medical, Little Canada, MN, USA) between June 2007 and June 2013. Patients were divided into three age groups: young patients aged ≤17 years; middle-aged patients aged 18-50 years; and older patients aged >50 years...
May 13, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28508451/the-impact-of-left-ventricular-diastolic-dysfunction-on-lung-transplant-outcome-in-patients-with-pulmonary-arterial-hypertension
#15
Avital Avriel, Anat Hershko Klement, Sindhu R Johnson, Marc de Perrot, John Granton
Diastolic dysfunction may influence perioperative outcome, early graft function and long-term survival. We compared the outcomes of DLTx for PAH patients with pre-operative LV diastolic dysfunction to those without diastolic dysfunction. Of 116 consecutive patients with PAH (who underwent transplantation between January 1995 and December 2013), 44 met our inclusion and exclusion criteria. Fourteen patients (31.8%) with diastolic dysfunction pre-LTx had a higher BMI [29 (IQR 21.5-32.6) vs. 22.4 (IRQ 19.9-25...
May 16, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28507082/association-between-diffuse-myocardial-fibrosis-and-diastolic-dysfunction-in-sickle-cell-anemia
#16
Omar Niss, Robert Fleck, Fowe Makue, Tarek Alsaied, Payal Desai, Jeffrey A Towbin, Punam Malik, Michael D Taylor, Charles T Quinn
Sickle cell anemia (SCA)-related cardiomyopathy is characterized by diastolic dysfunction and hyperdynamic features. Diastolic dysfunction portends early mortality in SCA. Diastolic dysfunction is associated with microscopic myocardial fibrosis in SCA mice, but the cause of diastolic dysfunction in humans with SCA is unknown. We used cardiac magnetic resonance (CMR) measurements of extracellular volume fraction (ECV) to discover and quantify diffuse myocardial fibrosis in 25 individuals with SCA (mean age 23±13 years), and determine the association between diffuse myocardial fibrosis and diastolic dysfunction...
May 15, 2017: Blood
https://www.readbyqxmd.com/read/28507060/alogliptin-a-dipeptidyl-peptidase-4-inhibitor-alleviates-atrial-remodeling-and-improves-mitochondrial-function-and-biogenesis-in-diabetic-rabbits
#17
Xiaowei Zhang, Zhiwei Zhang, Yungang Zhao, Ning Jiang, Jiuchun Qiu, Yajuan Yang, Jian Li, Xue Liang, Xinghua Wang, Gary Tse, Guangping Li, Tong Liu
BACKGROUND: There is increasing evidence implicating atrial mitochondrial dysfunction in the pathogenesis of atrial fibrillation. In this study, we explored whether alogliptin, a dipeptidyl peptidase-4 inhibitor, can prevent mitochondrial dysfunction and atrial remodeling in a diabetic rabbit model. METHODS AND RESULTS: A total of 90 rabbits were randomized into 3 groups as follows: control group (n=30), alloxan-induced diabetes mellitus group (n=30), and alogliptin-treated (12...
May 15, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28506917/atrial-antitachycardia-pacing-and-atrial-remodeling-a-substudy-of-the-international-randomized-minerva-trial
#18
Giuseppe Boriani, Raymond Tukkie, Mauro Biffi, Lluis Mont, Renato Ricci, Helmut Pürerfellner, Giovanni Luca Botto, Antonis S Manolis, Maurizio Landolina, Michele Gulizia, J Harrison Hudnall, Lorenza Mangoni, Andrea Grammatico, Luigi Padeletti
BACKGROUND: Atrial tachycardia (AT) and atrial fibrillation (AF) are common in pacemaker patients and are associated with bad prognosis. OBJECTIVE: To evaluate atrial antitachycardia pacing impact on AT/AF induced atrial remodeling, measured by early recurrence of AT/AF (ERAF) and by change in left atrium diameter (LAD). To evaluate impact of AT/AF duration on ERAF incidence. METHODS: Pacemaker patients were randomized to dual-chamber pacing (Control DDDR-385 patients), managed ventricular pacing (MVP-398 patients) or atrial antitachycardia pacing plus MVP (DDDRP+MVP-383 patients)...
May 12, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28499044/determinants-of-decline-of-renal-function-in-treated-hypertensive-patients-the-campania-salute-network
#19
Costantino Mancusi, Raffaele Izzo, Giovanni de Simone, Maria Viviana Carlino, Grazia Canciello, Eugenio Stabile, Nicola de Luca, Bruno Trimarco, Maria Angela Losi
Background.: Hypertension is a leading cause of chronic kidney disease (CKD) and a decrease in glomerular filtration rate (GFR) is associated with a higher prevalence of hypertension and an increased proportion of suboptimal blood pressure (BP) control. Methods.: To investigate characteristics associated with GFR decline, we selected 4539 hypertensive patients from the Campania Salute Network (mean age 53 ± 11 years) with at least 3 years of follow-up (FU) and no more than Stage III CKD...
May 12, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28497496/percutaneous-left-atrial-decompression-in-adults-with-refractory-cardiogenic-shock-supported-with-veno-arterial-extracorporeal-membrane-oxygenation
#20
Mosaad Alhussein, Mark Osten, Eric Horlick, Heather Ross, Eddy Fan, Vivek Rao, Filio Billia
BACKGROUND AND AIM OF THE STUDY: Left ventricular (LV) distention, a recognized complication in patients supported with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shock, can lead to pulmonary edema, increased myocardial oxygen consumption, and LV thrombus formation. Atrial septostomy was examined as a management strategy for LV distension. METHODS: Of 72 patients supported with VA-ECMO, seven patients underwent atrial septostomy through a trans-septal approach...
May 11, 2017: Journal of Cardiac Surgery
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