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https://www.readbyqxmd.com/read/28813234/cardiac-mr-strain-a-noninvasive-biomarker-of-fibrofatty-remodeling-of-the-left-atrial-myocardium
#1
Adrian T Huber, Jérôme Lamy, Amer Rahhal, Morgane Evin, Fabrice Atassi, Carine Defrance, Guillaume Lebreton, Karine Clément, Myriam Berthet, Richard Isnard, Pascal Leprince, Philippe Cluzel, Stéphane N Hatem, Nadjia Kachenoura, Alban Redheuil
Purpose To determine whether left atrial (LA) strain quantification with cardiac magnetic resonance (MR) imaging feature tracking is associated with the severity of LA fibrofatty myocardial remodeling at histologic analysis. Materials and Methods This prospective case-control study was approved by the institutional review board. LA strain was evaluated with cardiac MR feature tracking between January 2014 and March 2015 in 13 consecutive patients (mean age, 61 years ± 19; nine male) with mitral regurgitation in the 24 hours before mitral valve surgery and 13 age- and sex-matched healthy control subjects...
August 16, 2017: Radiology
https://www.readbyqxmd.com/read/28796004/effects-of-exercise-training-on-exercise-capacity-cardiac-function-bmi-and-quality-of-life-in-patients-with-atrial-fibrillation-a-meta-analysis-of-randomized-controlled-trials
#2
Michitaka Kato, Akira Kubo, Fumi Nihei, Michio Ogano, Hisato Takagi
Exercise training has become part of the standard care for patients with cardiovascular disease. We investigated the effects of exercise training on exercise capacity, cardiac function, BMI, and quality of life in patients with atrial fibrillation (AF). We searched for randomized-controlled trials of supervised exercise training versus care without exercise training (the control) in patients with permanent or nonpermanent AF published up to November 2016. Standard mean differences (SMD) or mean differences (MD), and 95% confidence intervals (CIs) were calculated using random-effect models...
September 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28794112/fifteen-genetic-loci-associated-with-the-electrocardiographic-p-wave
#3
Ingrid E Christophersen, Jared W Magnani, Xiaoyan Yin, John Barnard, Lu-Chen Weng, Dan E Arking, Maartje N Niemeijer, Steven A Lubitz, Christy L Avery, Qing Duan, Stephan B Felix, Joshua C Bis, Kathleen F Kerr, Aaron Isaacs, Martina Müller-Nurasyid, Christian Müller, Kari E North, Alex P Reiner, Lesley F Tinker, Jan A Kors, Alexander Teumer, Astrid Petersmann, Moritz F Sinner, Petra Buzkova, Jonathan D Smith, David R Van Wagoner, Uwe Völker, Melanie Waldenberger, Annette Peters, Thomas Meitinger, Marian C Limacher, Kirk C Wilhelmsen, Bruce M Psaty, Albert Hofman, Andre Uitterlinden, Bouwe P Krijthe, Zhu-Ming Zhang, Renate B Schnabel, Stefan Kääb, Cornelia van Duijn, Jerome I Rotter, Nona Sotoodehnia, Marcus Dörr, Yun Li, Mina K Chung, Elsayed Z Soliman, Alvaro Alonso, Eric A Whitsel, Bruno H Stricker, Emelia J Benjamin, Susan R Heckbert, Patrick T Ellinor
BACKGROUND: The P wave on an ECG is a measure of atrial electric function, and its characteristics may serve as predictors for atrial arrhythmias. Increased mean P-wave duration and P-wave terminal force traditionally have been used as markers for left atrial enlargement, and both have been associated with increased risk of atrial fibrillation. Here, we explore the genetic basis of P-wave morphology through meta-analysis of genome-wide association study results for P-wave duration and P-wave terminal force from 12 cohort studies...
August 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28794054/cardiovascular-event-prediction-by-machine-learning-the-multi-ethnic-study-of-atherosclerosis
#4
Bharath Ambale-Venkatesh, Xiaoying Yang, Colin O Wu, Kiang Liu, W G Hundley, Robyn L McClelland, Antoinette S Gomes, Aaron R Folsom, Steven Shea, Eliseo Guallar, David A Bluemke, João A Lima
Rationale: Machine learning may be useful to characterize cardiovascular risk, predict outcomes and identify biomarkers in population studies. Objective: To test the ability of random survival forests (RF), a machine learning technique, to predict six cardiovascular outcomes in comparison to standard cardiovascular risk scores. Methods and Results: We included participants from the Multi-Ethnic Study of Atherosclerosis (MESA). Baseline measurements were used to predict cardiovascular outcomes over 12 years of follow-up...
August 9, 2017: Circulation Research
https://www.readbyqxmd.com/read/28782130/left-atrial-phasic-function-and-heart-rate-variability-in-patients-with-systemic-sclerosis-a-new-part-of-the-old-puzzle
#5
Marijana Tadic, Maja Zlatanovic, Cesare Cuspidi, Ana Stevanovic, Vesna Kocijancic, Sinisa U Pavlovic, Nemanja Damjanov, Vera Celic
OBJECTIVE: We aimed to research left atrial (LA) phasic function and heart rate variability (HRV), as well as their relationship, in subjects with uncomplicated systemic sclerosis (SSc). METHODS: The investigation involved 44 SSc patients and 33 age-matched healthy controls. All participants underwent clinical examination, serological tests, 24-hours Holter monitoring, and echocardiographic examination including strain analysis. RESULTS: Maximum, minimum, and pre-A LA volumes and volume indices were higher in the SSc patients than in the controls...
August 7, 2017: Echocardiography
https://www.readbyqxmd.com/read/28776931/the-relationship-between-nighttime-hypertension-and-left-atrial-function
#6
Marijana Tadic, Cesare Cuspidi, Biljana Pencic-Popovic, Vera Celic, Giuseppe Mancia
The authors sought to investigate the association between different hypertensive phenotypes and left atrial (LA) function assessed by the volumetric method and the strain method in patients with untreated hypertension. This cross-sectional study involved 236 untreated patients who underwent 24-hour ambulatory blood pressure monitoring and two-dimensional echocardiographic examination. Our findings showed that LA function gradually deteriorated from patients with normotension, across patients with daytime hypertension, to patients with night- and day-nighttime hypertension...
August 3, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28774377/association-of-estimated-sodium%C3%A2-intake%C3%A2-with-adverse-cardiac-structure-and%C3%A2-function-from-the-hypergen-study
#7
Senthil Selvaraj, Luc Djoussé, Frank G Aguilar, Eva E Martinez, Vincenzo B Polsinelli, Marguerite R Irvin, Donna K Arnett, Sanjiv J Shah
BACKGROUND: The optimal level of sodium intake remains controversial. OBJECTIVES: This study sought to determine whether examination of left ventricular longitudinal strain (LS), circumferential strain, and e' velocity can provide insight into thresholds for the detrimental effects of estimated sodium intake (ESI) on subclinical cardiovascular disease. METHODS: We performed speckle-tracking analysis on HyperGEN (Hypertension Genetic Epidemiology Network) study echocardiograms with available urinary sodium data (N = 2,996)...
August 8, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28770032/effects-of-decreased-annular-height-and-annular-saddle-shaped-non-planarity-in-degenerative-severe-mitral-regurgitation-with-normal-left-ventricular-ejection-fraction-real-time-3d-transesophageal-echocardiography
#8
Eun Jeong Cho, Sung-Ji Park, Ga Yeon Lee, Eun Kyoung Kim, Sung-A Chang, Jin-Oh Choi, Sang-Chol Lee, Seung Woo Park, Pyo Won Park
BACKGROUND: The extent of mitral annular (MA) remodeling and dysfunction is correlated with the severity of mitral regurgitation (MR) as well as left atrial (LA) and left ventricular (LV) dilation. MA dysfunction may be a useful prognostic factor for operative timing and MR recurrence after successful mitral valve (MV) repair. The aim of this study was to evaluate additive prognostic factors of MA non-planarity using real-time 3D transesophageal echocardiography (RT3D-TEE) analysis in patients with chronic severe MR and preserved LV systolic function...
June 2017: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28760462/histone-modification-is-correlated-with-reverse-lv-remodeling-in-nonischemic-dilated-cardiomyopathy
#9
Emiko Ito, Shigeru Miyagawa, Satsuki Fukushima, Yasushi Yoshikawa, Shunsuke Saito, Tetsuya Saito, Akima Harada, Maki Takeda, Noriyuki Kashiyama, Yuki Nakamura, Motoko Shiozaki, Koichi Toda, Yoshiki Sawa
BACKGROUND: Although implantation of a left ventricular assist device (LVAD) induces reverse remodeling of the left ventricle in end-stage nonischemic dilated cardiomyopathy (DCM), the underlying mechanism is not fully understood. It has been shown that epigenetic modification, such as methylation or acetylation of the histone, is one of the most important upstream signals in cardiac failure. This study hypothesized that histone profiles may be modified by LVAD implantation for end-stage nonischemic DCM, in association with reverse left ventricular remodeling...
July 28, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28759817/left-atrial-remodeling-hypertrophy-and-fibrosis-in-mouse-models-of-heart-failure
#10
Waqas Hanif, Linda Alex, Ya Su, Arti V Shinde, Ilaria Russo, Na Li, Nikolaos G Frangogiannis
Left ventricular dysfunction increases left atrial pressures and causes atrial remodeling. In human subjects, increased left atrial size is a powerful predictor of mortality and adverse events in a broad range of cardiac pathologic conditions. Moreover, structural remodeling of the atrium plays an important role in the pathogenesis of atrial tachyarrhythmias. Despite the potential value of the atrium in assessment of functional endpoints in myocardial disease, atrial pathologic alterations in mouse models of left ventricular disease have not been systematically investigated...
June 21, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28758803/assessment-of-left-atrium-and-diastolic-dysfunction-in-patients-with-hypertensive-retinopathy-a-real-time-three-dimensional-echocardiography-based-study
#11
Batur Gonenc Kanar, Hatice Selen Kanar, Aysu Karatay, Kursat Tigen, Ayse Sonmez
The fundoscopic examination of hypertensive patients, which is established hypertension-related target organ damage (TOD), tends to be underutilized in clinical practice. We sought to investigate the relationship between retinal alterations and left atrium (LA) volumes by means of real-time three-dimensional echocardiography (RT3DE). Our population consisted of 88 consecutive essential hypertensive patients (age 59.2 ± 1.2 years, 35 males). All subjects underwent a fundoscopy examination and were distributed into four groups according to the Keith-Wagener-Barker (KWB) classification...
July 31, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28758067/left-atrial-morphology-and-function-a-strong-cardiovascular-predictor-of-outcome
#12
Maria Chiara Todaro
No abstract text is available yet for this article.
July 2017: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/28754308/association-between-metabolic-syndrome-and-fragmented-qrs-complexes-speckle-tracking-echocardiography-study
#13
Adil Bayramoğlu, Hakan Taşolar, Osman Bektaş, Mehmet Yaman, Yasemin Kaya, Muhammet Özbilen, Ahmet Kaya
BACKGROUND: Metabolic syndrome (MetS) is an endocrinological disease with both metabolic and physiological components. Previous studies have shown a relationship between MetS and left ventricular (LV) dysfunction. A fragmented QRS (fQRS) is a reliable electrocardiogram (ECG) finding with the importance of an indicator of myocardial fibrosis and scarring. In this study, we examined the utility of speckle tracking echocardiography (STE) in assessing LV function in MetS patients with fQRS...
June 27, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28752782/the-feasibility-of-substituting-left-atrial-wall-strain-for-flow-velocity-of-left-atrial-appendage
#14
Akihito Miyoshi, Yoichi Nakamura, Yukio Kazatani, Hiroshi Ito
OBJECTIVE: Non-valvular atrial fibrillation (NVAF) is frequently complicated by thromboembolism. Left atrial appendage (LAA) flow is a predictor of LAA thrombosis. LAA flow is measured by transesophageal echocardiography (TEE), which is a semi-invasive diagnostic tool. Recently, speckle-tracking methods have been adapted for the evaluation of local cardiac function. We hypothesised that if we could determine LAA wall motion utilising a speckle tracking technique, we could non-invasively analyse LAA flow...
July 28, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28752727/assessment-of-left-atrial-function-in-patients-with-hypertrophic-cardiomyopathy-using-two-dimensional-strain-a-comparison-with-volume-derived-values
#15
Jun Huang, Zi-Ning Yan, Yi-Fei Rui, Li Fan, Dan Shen, Dong-Liang Chen
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a common heart disease. Left atrial (LA) function plays an important role in the diastolic function in patients with HCM. In this study, two-dimensional speckle tracking imaging (2D-STI) was used to assess left atrial (LA) function in patients with HCM. METHODS: Thirty-four patients with HCM and thirty-four age- and gender-matched normal subjects were studied. The LA volume-derived index was measured using 2D ultrasonic images...
July 27, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28751436/a-striking-image-of-spontaneous-echo-contrast-in-severe-mitral-stenosis-in-a-patient-with-good-international-normalised-ratio-inr-control
#16
Daniel A Jeffery, Guy Lloyd, Arjun K Ghosh
No abstract text is available yet for this article.
September 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28750997/-atrial-functional-mitral-regurgitation-three-dimensional-echocardiographic-study
#17
José Miguel Hernández-Ramírez, José Ramón Ortega-Trujillo
INTRODUCTION AND OBJECTIVES: Atrial fibrillation can lead to a left atrium remodeling and induce functional mitral regurgitation. The aim of this study is to establish what features of the mitral annulus are related to atrial functional mitral regurgitation. METHODS: Retrospectively 29 patients with persistent atrial fibrillation and 36 controls in sinus rhythm were enrolled. The characteristics of the mitral annulus were analyzed by three-dimensional transesophageal echocardiography in both groups...
July 24, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28749900/increase-of-autonomic-nerve-factors-in-epicardial-ganglionated-plexi-during-rapid-atrial-pacing-induced-acute-atrial-fibrillation
#18
Yang Li, Yan-Mei Lu, Xian-Hui Zhou, Ling Zhang, Yao-Dong Li, Jiang-Hua Zhang, Qiang Xing, Bao-Peng Tang
BACKGROUND The cardiac autonomic nervous system plays an essential role in epicardial ganglionated plexi (GP) regulation of atrial fibrillation onset and progression. To date, the activity of GP and the function of the cardiac autonomic nervous system are not well understood. The aim of this study was to determine alterations in epicardial GP cholinergic nerve, adrenergic nerve, and nerve growth factor expression using rapid atrial pacing to induce atrial fibrillation in canines. MATERIAL AND METHODS Nine healthy adult beagles were divided into two groups: the pacing experimental group (n=6) and the sham-operation control group (n=3)...
July 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28747025/platelet-function-and-microparticle-levels-in-atrial-fibrillation-changes-during-the-acute-episode
#19
Line Pourtau, Jean Marc Sellal, Romaric Lacroix, Philippe Poncelet, Olivier Bernus, Gisèle Clofent-Sanchez, Mélèze Hocini, Michel Haïssaguerre, Françoise Dignat-George, Frédéric Sacher, Paquita Nurden
BACKGROUND: Thrombotic risk constitutes a major complication of atrial fibrillation (AF). Platelets and microparticles (MPs) are important for hemostasis and thrombosis, however their participation during AF is not well known. The aim of this study was to characterize platelet function and MPs procoagulant and fibrinolytic activity in AF patients and to determine the effects of an acute-AF episode. METHODS: Blood was collected from paroxysmal (21) and persistent (16) AF patients referred for AF catheter ablation...
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28746816/expression-of-classical-mediators-in-hearts-of-rats-with-hepatic-dysfunction
#20
Dagmar Jarkovska, Monika Bludovska, Eliska Mistrova, Vera Krizkova, Dana Kotyzova, Tereza Kubikova, Jana Slavikova, Sumeyye Nur Erek, Aleksandar Djordjevic, Magdalena Chottova Dvorakova
Liver cirrhosis is associated with impairment of cardiovascular function including alterations of the heart innervation, humoral and nervous dysregulation, changes in systemic circulation and electrophysiological abnormalities. Choline acetyltransferase (ChAT), enzyme forming acetylcholine, tyrosine hydroxylase (TH) and dopamine-β-hydroxylase (DBH), enzymes participating in noradrenaline synthesis, are responsible for the production of classical neurotransmitters and atrial natriuretic peptide (ANP) is produced by cardiomyocytes...
July 26, 2017: Canadian Journal of Physiology and Pharmacology
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