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Nanoparticles and molecular imaging

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https://www.readbyqxmd.com/read/28347131/preclinical-in-vivo-cancer-straightway-to-patients
#1
Marion de Jong, Stephen Mather, Theodosia Maina
Detection of useful cellular targets has strongly stimulated personalized tumor-targeted imaging and therapy approaches, also involving synthesis and evaluation of nuclear imaging probes with potential for clinical applications. Reviews of preclinical and translational studies concerning such probes, including radiolabeled antibodies, nanobodies, affibodies, peptides, small molecule inhibitors, and nanoparticles, are presented in this issue. As most tracers described in these articles have been developed for the field of cancer imaging and radionuclide therapy, the current article on preclinical studies will focus on cancer research as well...
June 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28335985/aqueous-phase-synthesis-of-iron-oxide-nanoparticles-and-composites-for-cancer-diagnosis-and-therapy
#2
REVIEW
Jingchao Li, Shige Wang, Xiangyang Shi, Mingwu Shen
The design and development of multifunctional nanoplatforms for biomedical applications still remains to be challenging. This review reports the recent advances in aqueous-phase synthesis of iron oxide nanoparticles (Fe3O4 NPs) and their composites for magnetic resonance (MR) imaging and photothermal therapy of cancer. Water dispersible and colloidally stable Fe3O4 NPs synthesized via controlled coprecipitation route, hydrothermal route and mild reduction route are introduced. Some of key strategies to improve the r2 relaxivity of Fe3O4 NPs and to enhance their uptake by cancer cells are discussed in detail...
March 14, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28335351/modified-nanoemulsions-with-iron-oxide-for-magnetic-resonance-imaging
#3
Yongyi Fan, Rui Guo, Xiangyang Shi, Steven Allen, Zhengyi Cao, James R Baker, Su He Wang
A nanoemulsion (NE) is a surfactant-based, oil-in-water, nanoscale, high-energy emulsion with a mean droplet diameter of 400-600 nm. When mixed with antigen and applied nasally, a NE acts as a mucosal adjuvant and induces mucosal immune responses. One possible mechanism for the adjuvant effect of this material is that it augments antigen uptake and distribution to lymphoid tissues, where the immune response is generated. Biocompatible iron oxide nanoparticles have been used as a unique imaging approach to study the dynamics of cells or molecular migration...
November 25, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335209/dye-doped-fluorescent-silica-nanoparticles-for-live-cell-and-in-vivo-bioimaging
#4
REVIEW
Wen-Han Zhang, Xiao-Xiao Hu, Xiao-Bing Zhang
The need for novel design strategies for fluorescent nanomaterials to improve our understanding of biological activities at the molecular level is increasing rapidly. Dye-doped fluorescent silica nanoparticles (SiNPs) emerge with great potential for developing fluorescence imaging techniques as a novel and ideal platform for the monitoring of living cells and the whole body. Organic dye-containing fluorescent SiNPs exhibit many advantages: they have excellent biocompatibility, are non-toxic, highly hydrophilic, optically transparent, size-tunable and easily modified with various biomolecules...
April 27, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28331783/nanoparticle-functionalization-and-its-potentials-for-molecular-imaging
#5
REVIEW
Rukmani Thiruppathi, Sachin Mishra, Mathangi Ganapathy, Parasuraman Padmanabhan, Balázs Gulyás
Functionalization enhances the properties and characteristics of nanoparticles through surface modification, and enables them to play a major role in the field of medicine. In molecular imaging, quality functional images are required with proper differentiation which can be seen with high contrast to obtain viable information. This review article discusses how functionalization enhances molecular imaging and enables multimodal imaging by which images with combination of functions particular to each modality can be obtained...
March 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28324863/croconaine-nanoparticles-with-enhanced-tumor-accumulation-for-multimodality-cancer-theranostics
#6
Longguang Tang, Fuwu Zhang, Fei Yu, Wenjing Sun, Menglin Song, Xiaoyuan Chen, Xianzhong Zhang, Xiaolian Sun
A novel nanoparticle self-assembled by polyethylene glycol (PEG) modified croconaine dye (CR780) is presented for photoacoustic (PA)/near-infrared (NIR) fluorescence imaging-guided photothermal therapy (PTT). The simple PEGylation made CR780 amphiphilic, and led to their self-assembly into well-defined and uniform nanostructures with size tunable by controlling the assembly conditions. The CR780-PEG5K not only displayed the strength of small molecules (including rapid distribution to different organs, fast renal clearance and minimal accumulation to normal tissues), but also demonstrated the advantages of nanomaterials (including high physiological stability, multimodal theranostic ability, high tumor accumulation and retention)...
March 13, 2017: Biomaterials
https://www.readbyqxmd.com/read/28306236/hydrophobic-ir-780-dye-encapsulated-in-crgd-conjugated-solid-lipid-nanoparticles-for-nir-imaging-guided-photothermal-therapy
#7
Ye Kuang, Kunchi Zhang, Yi Cao, Xing Chen, Kewei Wang, Min Liu, Renjun Pei
It is highly demanded to improve the accumulation of NIR theranostic agents in tumor region, which is favorable to the effective phototherapy. IR-780 iodide, a near-infrared (NIR) fluorescence dye, possesses higher and more stable fluorescence intensity than clinically applied dye indocyanine green (ICG), and can be utilized in imaging-guided photothermal therapy with laser irradiation. However, lipophilicity, short circulation time and lack of targeting specificity limit its applications in cancer imaging and therapy...
March 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28301745/applications-of-surface-second-harmonic-generation-in-biological-sensing
#8
Renee J Tran, Krystal L Sly, John C Conboy
Surface second harmonic generation (SHG) is a coherent, nonlinear optical technique that is well suited for investigations of biomolecular interactions at interfaces. SHG is surface specific due to the intrinsic symmetry constraints on the nonlinear process, providing a distinct analytical advantage over linear spectroscopic methods, such as fluorescence and UV-Visible absorbance spectroscopies. SHG has the ability to detect low concentrations of analytes, such as proteins, peptides, and small molecules, due to its high sensitivity, and the second harmonic response can be enhanced through the use of target molecules that are resonant with the incident (ω) and/or second harmonic (2ω) frequencies...
March 16, 2017: Annual Review of Analytical Chemistry
https://www.readbyqxmd.com/read/28296388/degradable-semiconducting-oligomer-amphiphile-for-ratiometric-photoacoustic-imaging-of-hypochlorite
#9
Chao Yin, Xu Zhen, Quli Fan, Wei Huang, Kanyi Pu
Upregulation of highly reactive oxygen species (ROS) such as hypochlorite (ClO-) is associated with many pathological conditions including cardiovascular diseases, neuron degeneration, lung injury and cancer. However, real-time imaging of ClO- is limited to the probes generally relying on fluorescence with shallow tissue-penetration depth. We here propose a self-assembly approach to develop activatable and degradable photoacoustic (PA) nanoprobes for in vivo imaging of ClO-. A near-infrared (NIR) absorbing amphiphilic oligomer was synthesized to undergo degradation in the presence of a specific ROS (ClO-), which integrates a π-conjugated but ClO- oxidizable backbone with hydrophilic PEG side chains...
March 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/28291322/lipid-nanodisc-templated-self-assembly-of-gold-nanoparticles-into-strings-and-rings
#10
Hari Sharma, Elena E Dormidontova
Gold nanoparticles (AuNPs) exhibit strong fluorescent and electromagnetic properties, which can be enhanced upon clustering and used in therapeutic, imaging and sensing applications. A combination of gold nanoparticles with lipid nanodiscs can be attractive for AuNP self-assembly and useful in biomedical applications. Using molecular dynamics simulations we show that lipid nanodiscs can serve as templates for AuNP clustering into rings and string-like structures. We demonstrate that equilibrium encapsulation of 1nm hydrophobically modified AuNPs into lipid nanodiscs composed of a mixture of dipalmitoyl phosphatidylcholine (DPPC) and dihexanoyl phosphatidylcholine (DHPC) lipids occurs at the rim and results in formation of a ring of gold...
March 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28287601/targeted-plasma-membrane-delivery-of-a-hydrophobic-cargo-encapsulated-in-a-liquid-crystal-nanoparticle-carrier
#11
Okhil K Nag, Jawad Naciri, Eunkeu Oh, Christopher M Spillmann, James B Delehanty
The controlled delivery of drug/imaging agents to cells is critical for the development of therapeutics and for the study of cellular signaling processes. Recently, nanoparticles (NPs) have shown significant promise in the development of such delivery systems. Here, a liquid crystal NP (LCNP)-based delivery system has been employed for the controlled delivery of a water-insoluble dye, 3,3'-dioctadecyloxacarbocyanine perchlorate (DiO), from within the NP core to the hydrophobic region of a plasma membrane bilayer...
February 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28284105/surface-engineering-of-semiconducting-polymer-nanoparticles-for-amplified-photoacoustic-imaging
#12
Xu Zhen, Xiaohua Feng, Chen Xie, Yuanjin Zheng, Kanyi Pu
Despite the deeper tissue penetration of photoacoustic (PA) imaging, its sensitivity is generally lower than optical imaging. This fact partially restricts the applications of PA imaging and greatly stimulates the development of sensitive PA imaging agents. We herein report that the surface coating of semiconducting polymer nanoparticles (SPNs) with the silica layer can simultaneously amplify fluorescence and PA brightness while maintaining their photothermal conversion efficiency nearly unchanged. As compared with the bare SPNs, the silica-coated SPNs (SPNs-SiO2) have higher photothermal heating rate in the initial stage of laser irradiation due to the higher interfacial thermal conductance between the silica layer and water relative to that between the SP and water...
March 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/28274767/copper-sulfide-nanoparticle-based-localized-drug-delivery-system-as-an-effective-cancer-synergistic-treatment-and-theranostic-platform
#13
Lin Hou, Xiaoning Shan, Lisha Hao, Qianhua Feng, Zhenzhong Zhang
Localized cancer treatment with combination therapy has attracted increasing attention for effective inhibition of tumor growth. In this work, we introduced diffusion molecular retention (DMR) tumor targeting effect, a new strategy that employed transferrin (Tf) modified hollow mesoporous CuS nanoparticles (HMCuS NPs) to undergo extensive diffuse through the interstitium and tumor retention after a peritumoral (PT) injection. Herein, HMCuS NPs with strong near-infrared (NIR) absorption and photothermal conversion efficiency could serve as not only a drug carrier but also a powerful contrast agent for photoacoustic imaging to guide chemo-phototherapy...
March 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28260837/facet-dependent-interactions-of-islet-amyloid-polypeptide-with-gold-nanoparticles-implications-for-fibril-formation-and-peptide-induced-lipid-membrane-disruption
#14
Shih-Ting Wang, Yiyang Lin, Nevena Todorova, Yingqi Xu, Manuel Mazo, Subinoy Rana, Vincent Leonardo, Nadav Amdursky, Christopher D Spicer, Bruce D Alexander, Alison A Edwards, Steve J Matthews, Irene Yarovsky, Molly M Stevens
A comprehensive understanding of the mechanisms of interaction between proteins or peptides and nanomaterials is crucial for the development of nanomaterial-based diagnostics and therapeutics. In this work, we systematically explored the interactions between citrate-capped gold nanoparticles (AuNPs) and islet amyloid polypeptide (IAPP), a 37-amino acid peptide hormone co-secreted with insulin from the pancreatic islet. We utilized diffusion-ordered spectroscopy, isothermal titration calorimetry, localized surface plasmon resonance spectroscopy, gel electrophoresis, atomic force microscopy, transmission electron microscopy (TEM), and molecular dynamics (MD) simulations to systematically elucidate the underlying mechanism of the IAPP-AuNP interactions...
February 28, 2017: Chemistry of Materials: a Publication of the American Chemical Society
https://www.readbyqxmd.com/read/28259932/albumin-based-nanoparticles-as-methylprednisolone-carriers-for-targeted-delivery-towards-the-neonatal-fc-receptor-in-glomerular-podocytes
#15
Lin Wu, Mingyu Chen, Huijuan Mao, Ningning Wang, Bo Zhang, Xiufen Zhao, Jun Qian, Changying Xing
Glucocorticoids (GCs) are commonly used in the treatment of nephrotic syndrome. However, high doses and long periods of GC therapy can result in severe side effects. The present study aimed to selectively deliver albumin‑methylprednisolone (MP) nanoparticles towards glomerular podocytes, which highly express the specific neonatal Fc receptor (FcRn) of albumin. Bovine serum albumin (BSA) was labeled with a fluorescent dye and linked with modified MP via an amide bond. The outcome nanoparticle named BSA633‑MP showed a uniform size with a diameter of approximately 10 nm and contained 12 drug molecules on average...
February 21, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28259207/polymer-decorated-gold-nanoparticles-in-nanomedicine-conjugates
#16
REVIEW
Ignác Capek
Noble metal, especially gold nanoparticles and their conjugates with biopolymers have immense potential for disease diagnosis and therapy on account of their surface plasmon resonance (SPR) enhanced light scattering and absorption. Conjugation of noble metal nanoparticles to ligands specifically targeted to biomarkers on diseased cells allows molecular-specific imaging and detection of disease. The development of smart gold nanoparticles (AuNPs) that can deliver therapeutics at a sustained rate directly to cancer cells may provide better efficacy and lower toxicity for treating cancer tumors...
February 15, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28255896/cell-and-tissue-imaging-with-molecularly-imprinted-polymers
#17
Maria Panagiotopoulou, Stephanie Kunath, Karsten Haupt, Bernadette Tse Sum Bui
Advanced tools for cell imaging are of particular interest as they can detect, localize and quantify molecular targets like abnormal glycosylation sites that are biomarkers of cancer and infection. Targeting these biomarkers is often challenging due to a lack of receptor materials. Molecularly imprinted polymers (MIPs) are promising artificial receptors; they can be tailored to bind targets specifically, be labeled easily, and are physically and chemically stable. Herein, we demonstrate the application of MIPs as artificial antibodies for selective labeling and imaging of cellular targets, on the example of hyaluronan and sialylation moieties on fixated human skin cells and tissues...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28255342/dual-targeted-and-ph-sensitive-doxorubicin-prodrug-microbubble-complex-with-ultrasound-for-tumor-treatment
#18
Wanxian Luo, Ge Wen, Li Yang, Jiao Tang, Jianguo Wang, Jihui Wang, Shiyu Zhang, Li Zhang, Fei Ma, Liling Xiao, Ying Wang, Yingjia Li
In this study, we investigated the potential of a dual-targeted pH-sensitive doxorubicin prodrug-microbubble complex (DPMC) in ultrasound (US)-assisted antitumor therapy. The doxorubicin prodrug (DP) consists of a succinylated-heparin carrier conjugated with doxorubicin (DOX) via hydrazone linkage and decorated with dual targeting ligands, folate and cRGD peptide. Combination of microbubble (MB) and DP, generated via avidin-biotin binding, promoted intracellular accumulation and improved therapeutic efficiency assisted by US cavitation and sonoporation...
2017: Theranostics
https://www.readbyqxmd.com/read/28254936/clathrate-colloidal-crystals
#19
Haixin Lin, Sangmin Lee, Lin Sun, Matthew Spellings, Michael Engel, Sharon C Glotzer, Chad A Mirkin
DNA-programmable assembly has been used to deliberately synthesize hundreds of different colloidal crystals spanning dozens of symmetries, but the complexity of the achieved structures has so far been limited to small unit cells. We assembled DNA-modified triangular bipyramids (~250-nanometer long edge, 177-nanometer short edge) into clathrate architectures. Electron microscopy images revealed that at least three different structures form as large single-domain architectures or as multidomain materials. Ordered assemblies, isostructural to clathrates, were identified with the help of molecular simulations and geometric analysis...
March 3, 2017: Science
https://www.readbyqxmd.com/read/28243083/heterogeneous-dimer-peptide-conjugated-polylysine-dendrimer-fe3o4-composite-as-a-novel-nanoscale-molecular-probe-for-early-diagnosis-and-therapy-in-hepatocellular-carcinoma
#20
Jian-Min Shen, Xin-Xin Li, Lin-Lan Fan, Xing Zhou, Ji-Min Han, Ming-Kang Jia, Liang-Fan Wu, Xiao-Xue Zhang, Jing Chen
A novel nanoscale molecular probe is formulated in order to reduce toxicity and side effects of antitumor drug doxorubicin (DOX) in normal tissues and to enhance the detection sensitivity during early imaging diagnosis. The mechanism involves a specific targeting of Arg-Gly-Asp peptide (RGD)-GX1 heterogeneous dimer peptide-conjugated dendrigraft poly-l-lysine (DGL)-magnetic nanoparticle (MNP) composite by αvβ3-integrin/vasculature endothelium receptor-mediated synergetic effect. The physicochemical properties of the nanoprobe were characterized by using transmission electron microscope, Fourier transform infrared spectroscopy, X-ray diffraction, dynamic light scattering (DLS), and vibrating sample magnetometer...
2017: International Journal of Nanomedicine
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