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Nanoparticles and molecular imaging

Kseniya Lugovik, Alexander Eltyshev, Polina Suntsova, Pavel Slepukhin, Enrico Benassi, Nataliya P Belskaya
Developing a novel, small-sized molecular building block that may be capable of emitting light in the solid state is a challenging task and has rarely been reported in the literature. BF2-containing dyes seem to be promising candidate towards this aim. Two series of new N^NBF2-complexes showing aggregation-induced emission (AIE) and aggregation-induced emission enhancement (AIEE) were designed and synthesized via a new protocol, which improves on the traditional method by employing microwave irradiation. The optical and photophysical properties of the BF2 complexes were investigated in depth...
December 14, 2017: Chemistry, An Asian Journal
Jae Young Kim, Eun Seok Seo, Hyunmin Kim, Ji-Won Park, Dong-Kwon Lim, Dae Won Moon
We report a high spatial resolution mass spectrometry (MS) system that allows us to image live hippocampal tissue slices under open-air atmospheric pressure (AP) and ambient temperature conditions at the subcellular level. The method is based on an efficient desorption process by femtosecond (fs) laser assisted with nanoparticles and a subsequent ionization step by applying nonthermal plasma, termed AP nanoparticle and plasma assisted laser desorption ionization (AP-nanoPALDI) MS method. Combining the AP-nanoPALDI with microscopic sample scanning, MS imaging with spatial resolution of 2...
December 13, 2017: Nature Communications
Emil Petrescu, Cristina Cirtoaje, Cristina Stan
The dynamic behavior of a mixture of 4-cyano-4'-pentylbiphenyl (5CB) with 1% CoFe2O4 nanoparticles was analyzed. Experimental data indicate a high stability of the nematic director in the mixture compared to a reference 5CB sample in the magnetic field. The ferrite nanoparticles agglomerate forming long chains as observed in polarized microscopy images. These chains have a very high influence on the magneto-optic effect of the cell. When the magnetic field is applied on the mixture, the chains tend to align with the field direction but, due to their large size, they remain oriented obliquely between the support plates...
2017: Beilstein Journal of Nanotechnology
Jaber Beik, Maryam Jafariyan, Alireza Montazerabadi, Ali Ghadimi-Daresajini, Parastoo Tarighi, Alireza Mahmoudabadi, Habib Ghaznavi, Ali Shakeri-Zadeh
X-ray computed tomography (CT) requires an optimal compromise between image quality and patient dose. While high image quality is an important requirement in CT, the radiation dose must be kept minimal to protect the patients from ionizing radiation-associated risks. The use of probes based on gold nanoparticles (AuNPs) along with active targeting ligands for specific recognition of cancer cells may be one of the balanced solutions. Herein, we report the effect of folic acid (FA)-modified AuNP as a targeted nanoprobe on the contrast enhancement of CT images as well as its potential for patient dose reduction...
December 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
Soyoung Kang, Yu Winston Wang, Xiaochun Xu, Eric Navarro, Kenneth M Tichauer, Jonathan T C Liu
Previous studies have shown that functionalized nanoparticles (NPs) topically applied on fresh tissues are able to rapidly target cell-surface protein biomarkers of cancer. Furthermore, studies have shown that a paired-agent approach, in which an untargeted NP is co-administered with a panel of targeted NPs, controls for nonspecific behavior of the NPs, enabling quantitative imaging of biomarker expression. However, given the complexities in nonspecific accumulation, diffusion, and chemical binding of targeted NPs in tissues, studies are needed to better understand these processes at the microscopic scale...
December 11, 2017: Journal of Biophotonics
Dan Wu, Yang Li, Jie Yang, Jie Shen, Jiong Zhou, Qinglian Hu, Guocan Yu, Guping Tang, Xiaoyuan Chen
An amphiphilic supramolecular brush copolymer CB[8](PEG-Np·PTPE) was constructed on the basis of a novel host-guest molecular recognition model formed by cucurbit[8]uril (CB[8]), 4,4'-bipyridinium derivative (PQ) and PEGylated naphthol (PEG-Np). In aqueous solution, the resultant supramolecular brush copolymer self-assembled into supramolecular nanoparticles (SNPs), by which anticancer drug doxorubicin (DOX) was encapsulated in the hydrophobic core, establishing an artful Förster resonance energy transfer (FRET) system with dual-fluorescence quenched...
December 5, 2017: ACS Applied Materials & Interfaces
Tamás Fülöp, Réka Nemes, Tamás Mészáros, Rudolf Urbanics, Robbert Jan Kok, Joshua A Jackman, Namjoon Cho, Gert Storm, János Szebeni
The unique magnetic properties of superparamagnetic iron oxide nanoparticles (SPIONs) have led to their increasing use in drug delivery and imaging applications. Some polymer-coated SPIONs, however, share with many other nanoparticles the potential of causing hypersensitivity reactions known as complement (C) activation-related pseudoallergy (CARPA). In order to explore the roles of iron core composition and particle surface coating in SPION-induced CARPA, we measured C activation by 6 different SPIONs in a human serum that is known to react to nanoparticles (NPs) with strong C activation...
December 1, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
Jingchao Li, Jianghong Rao, Kanyi Pu
As a new class of organic optical nanomaterials, semiconducting polymer nanoparticles (SPNs) have the advantages of excellent optical properties, high photostability, facile surface functionalization, and are considered to possess good biocompatibility for biomedical applications. This review surveys recent progress made on the design and synthesis of SPNs for molecular imaging and cancer phototherapy. A variety of novel polymer design, chemical modification and nanoengineering strategies have been developed to precisely tune up optoelectronic properties of SPNs to enable fluorescence, chemiluminescence and photoacoustic (PA) imaging in living animals...
November 21, 2017: Biomaterials
Loredana Ricciardi, Lucie Sancey, Giovanna Palermo, Roberto Termine, Antonio De Luca, Elisabeta I Szerb, Iolinda Aiello, Mauro Ghedini, Giuseppe Strangi, Massimo La Deda
A nanoplatform for simultaneous cellular imaging, and photodynamic and photothermal therapies has been designed and realized by embedding a purposely synthesized highly luminescent water soluble iridium(iii) compound into gold core-silica shell nanoparticles. These multifunctionalities arise mainly from the photophysical properties of the cyclometalated complex: (i) the heavy atom promotes, through excited triplet state formation, energy transfer processes towards molecular oxygen, with the generation of 1O2 (photodynamic effect); (ii) the overlap of the iridium(iii) complex emission band with the plasmonic resonance of gold nanostructures allows excitation energy transfer towards the metallic core (photothermal effect); (iii) the remarkable iridium(iii) complex luminescence feature, which is preserved despite energy transfer processes, makes the whole system an efficient luminescent bio-probe (imaging)...
November 30, 2017: Nanoscale
Marziyeh Poshteh Shirani, Behzad Rezaei, Taghi Khayamian, Mohammad Dinari, Kazem Karami, Zohreh Mehri-Lighvan, Fazileh Hosseini Shamili, Mohammd Ramezani, Mona Alibolandi
New folic acid-conjugated mesoporous silica nanoparticles were synthesized. The effect of calcination at 400°C on the fluorescence characteristics of mesoporous silica nanoparticles was studied in this work. The formed carbon dots (CDs) from calcination was used as the source of fluorescence. 3-Aminopropyltriethoxysilane was then used to amine-functionalized the fluorescent surface of mesoporous silica nanoparticles. The amine fluorescence mesoporous silica nanoparticles (amine-FMSNs) were coupled with folic acid (FA) as the target ligand (FA-amine-FMSNs)...
November 30, 2017: Journal of Biomolecular Structure & Dynamics
Stephanie J Blocker, Anthony F Shields
Molecular imaging is a vital tool to non-invasively measure nanoparticle delivery to solid tumors. Despite the myriad of nanoparticles studied for cancer, successful applications of nanoparticles in humans is limited by inconsistent and ineffective delivery. Successful nanoparticle delivery in preclinical models is often attributed to enhanced permeability and retention (EPR)-a set of conditions that is heterogeneous and transient in patients. Thus, researchers are evaluating therapeutic strategies to modify nanoparticle delivery, particularly treatments which have demonstrated effects on EPR conditions...
November 29, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Yong Cao, Bethany Griffith, Prasanna Bhomkar, David S Wishart, Mark T McDermott
The development of sensing systems for the measurement of small molecules is an active area of research. A sensor based approach for the measurement of metabolites can potentially provide the simplicity and portability required for widespread use. Rapid detection and quantitation of small-molecule metabolites can potentially emerge as an effective way to link the metabolite profile to the disease state. Surface plasmon resonance (SPR) combined with molecular recognition elements to deliver high specificity is a sensing platform that has been widely applied for a large range of biomolecules...
November 29, 2017: Analyst
Hyeon-Yeol Cho, Md Khaled Hossain, Jin-Ho Lee, Jiyou Han, Hun Joo Lee, Kyeong-Jun Kim, Jong-Hoon Kim, Ki-Bum Lee, Jeong-Woo Choi
Circulating cancer stem cells (CCSCs), a rare circulating tumor cell (CTC) type, recently arose as a useful resource for monitoring and characterizing both cancers and their metastatic derivatives. However, due to the scarcity of CCSCs among hematologic cells in the blood and the complexity of the phenotype confirmation process, CCSC research can be extremely challenging. Hence, we report a nanoparticle-mediated Raman imaging method for CCSC characterization which profiles CCSCs based on their surface marker expression phenotypes...
November 16, 2017: Biosensors & Bioelectronics
Veronika Sutrova, Ivana Sloufova, Zuzana Melnikova, Martin Kalbac, Ewa Pavlova, Blanka Vlckova
Single layer graphene (SLG) and 2-dimensional (2-D) plasmonic Ag nanoparticle arrays assembled by chemisorption of ethanethiol (ET) molecules (AgNPs-ET) were employed as components of two types of hybrid systems designed for surface-enhanced Raman scattering (SERS) spectral probing of SLG localized in the vicinity of plasmonic NPs. Both hybrids were characterized by optical microscopy, transmission electron microscopy (TEM), surface plasmon extinction (SPE) and SERS microRaman spectral measurements at four excitation wavelengths spanning the 445-780 nm range...
November 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Huai-Lu Chen, Fei-Ting Hsu, Yu-Chieh Jill Kao, Hua-Shan Liu, Wan-Zhen Huang, Chia-Feng Lu, Ping-Huei Tsai, Ahmed Atef Ahmed Ali, Gilbert Aaron Lee, Ray-Jade Chen, Cheng-Yu Chen
BACKGROUND: Targeted superparamagnetic iron oxide (SPIO) nanoparticles have emerged as a promising biomarker detection tool for molecular magnetic resonance (MR) image diagnosis. To identify patients who could benefit from Epidermal growth factor receptor (EGFR)-targeted therapies, we introduce lipid-encapsulated SPIO nanoparticles and hypothesized that anti-EGFR antibody cetuximab conjugated of such nanoparticles can be used to identify EGFR-positive glioblastomas in non-invasive T2 MR image assays...
November 22, 2017: Journal of Nanobiotechnology
Charles W Heaps, George C Schatz
A computational method to model diffraction-limited images from super-resolution surface-enhanced Raman scattering microscopy is introduced. Despite significant experimental progress in plasmon-based super-resolution imaging, theoretical predictions of the diffraction limited images remain a challenge. The method is used to calculate localization errors and image intensities for a single spherical gold nanoparticle-molecule system. The light scattering is calculated using a modification of generalized Mie (T-matrix) theory with a point dipole source and diffraction limited images are calculated using vectorial diffraction theory...
June 14, 2017: Journal of Chemical Physics
Zhichao Lou, He Han, Ming Zhou, Jinfeng Wan, Qian Sun, Xiaoyan Zhou, Ning Gu
Herein, a novel sandwich surface plasmon resonance (SPR) detection assay, which utilizes prion disease-associated isoform (PrPSc) conjugating magnetic nanoparticle clusters (nanoparticle-organic clusters, NOCs) as signal amplification reagents, is constructed for ultrasensitive detection of PrPSc. Due to the highly specific affinity of aptamer-Fe3O4 nanoparticles (AMNPs) towards PrPSc and the intermolecular assembly behaviors among PrPSc, PrPSc conjugating magnetic nanoparticle clusters were obtained after the incubation of AMNPs and PrPSc, and the subsequent concentration processes in an external magnetic field...
November 22, 2017: Analytical Chemistry
Jie Xu, Jun Zhou, Yixin Zhong, Yu Zhang, Jia Liu, Yuli Chen, Liming Deng, Danli Sheng, Zhigang Wang, Haitao Ran, Dajing Guo
Thrombotic disease is extremely harmful to human health, and early detection and treatment can improve the prognosis and reduce mortality. Multimodal molecular imaging can provide abundant information about thrombi, but to date, few studies have used multimodal and multifunctional nanoparticles (NPs) for thrombus detection and targeting thrombolysis. In this study, phase transition multimodal and multifunctional NPs (EWVDV-Fe-Ink-PFH NPs) were constructed for the first time using a three-step emulsification and carbodiimide method, and the physical and chemical properties of the NPs were investigated...
November 21, 2017: ACS Applied Materials & Interfaces
Xue-Sen Hou, Guo-Long Zhu, Li-Jun Ren, Zihan Huang, Rui-Bin Zhang, Goran Ungar, Li-Tang Yan, Wei Wang
Honeycomb structure endows graphene with extraordinary properties. But could a honeycomb monolayer superlattice also be gen-erated via self-assembly of colloids or nanoparticles? Here we report the construction of mono- and multilayer molecular films with honeycomb structure that can be regarded as self-assembled artificial graphene (SAAG). We construct fan-shaped molecular building blocks by covalently connecting two kinds of clusters, one polyoxometalate (POM) and four polyhedral oligomeric silsesquioxanes (POSS)...
November 21, 2017: Journal of the American Chemical Society
Jinyuan Ma, Yang Li, Guihua Liu, Ai Li, Yilin Chen, Xinyi Zhou, Dengyue Chen, Zhenqing Hou, Xuan Zhu
The novel drug delivery system based on self-assembly of zinc phthalocyanine-soybean phosphatidylcholine (ZnPc-SPC) complex was developed by a co-solvent method followed by a nanoprecipitaion technique. DSPE-PEG-methotrexate (DSPE-PEG-MTX) was introduced on the surface of ZnPc-SPC self-assembled nanoparticles (ZS) to endow them with folate receptor-targeting property. NMR, XRD, FTIR, and UV-vis-NIR analysis demonstrated the weak molecular interaction between ZnPc and SPC. The ZS functionalized with DSPE-PEG-MTX (ZSPM) was successfully constructed with an average particle size of ∼170nm, a narrow size distribution, and could remain physiologically stable for at least 7days...
October 24, 2017: Colloids and Surfaces. B, Biointerfaces
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