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Nanoparticles and molecular imaging

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https://www.readbyqxmd.com/read/28537320/understanding-the-adsorptive-interactions-of-arsenate-iron-nanoparticles-with-curved-fullerene-like-sheets-in-activated-carbon-using-a-quantum-mechanics-molecular-mechanics-computational-approach
#1
Nguyen Ngoc Ha, Le Minh Cam, Nguyen Thi Thu Ha, Bee-Min Goh, Martin Saunders, Zhong-Tao Jiang, Mohammednoor Altarawneh, Bogdan Z Dlugogorski, Mohanad El-Harbawi, Chun-Yang Yin
The prevalence of global arsenic groundwater contamination has driven widespread research on developing effective treatment systems including adsorption using various sorbents. The uptake of arsenic-based contaminants onto established sorbents such as activated carbon (AC) can be effectively enhanced via immobilization/impregnation of iron-based elements on the porous AC surface. Recent suggestions that AC pores structurally consist of an eclectic mix of curved fullerene-like sheets may affect the arsenic adsorption dynamics within the AC pores and is further complicated by the presence of nano-sized iron-based elements...
May 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28531102/nanoparticles-as-theranostic-vehicles-in-experimental-and-clinical-applications-focus-on-prostate-and-breast-cancer
#2
REVIEW
Jörgen Elgqvist
Prostate and breast cancer are the second most and most commonly diagnosed cancer in men and women worldwide, respectively. The American Cancer Society estimates that during 2016 in the USA around 430,000 individuals were diagnosed with one of these two types of cancers, and approximately 15% of them will die from the disease. In Europe, the rate of incidences and deaths are similar to those in the USA. Several different more or less successful diagnostic and therapeutic approaches have been developed and evaluated in order to tackle this issue and thereby decrease the death rates...
May 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28530277/advanced-microscopy-and-spectroscopy-reveal-the-adsorption-and-clustering-of-cu-ii-onto-tempo-oxidized-cellulose-nanofibers
#3
Chuantao Zhu, Alexander Soldatov, Aji P Mathew
TEMPO (2,2,6,6-tetramethylpiperidine-1-oxylradical)-mediated oxidation nanofibers (TOCNF), as a biocompatible and bioactive material, have opened up a new application of nanocellulose for the removal of water contaminants. This development demands extremely sensitive and accurate methods to understand the surface interactions between water pollutants and TOCNF. In this report, we investigated the adsorption of metal ions on TOCNF surfaces using experimental techniques atthe nano and molecular scales with Cu(ii) as the target pollutant in both aqueous and dry forms...
May 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28524648/instantaneous-ph-boosted-functionalization-of-stellate-gold-nanoparticles-for-intracellular-imaging-of-mirna
#4
Jisun Ki, Eunji Jang, Seungmin Han, Moo-Kwang Shin, Byunghoon Kang, Yong-Min Huh, Seungjoo Haam
Various types of nanoprobes have recently been utilized to monitor living organisms by detecting and imaging intracellular biomarkers, such as microRNAs (miRs). We here present a simple one-pot method to prepare stellate gold nanoparticles functionalized with miR-detecting molecular beacons (SGNP-MBs); low pH conditions permitted the rapid-high loading of MBs on the surface of SGNPs. Compared to the conventional gold nanoparticle-based MBs, SGNPs carried a 4.5-fold higher load of MBs and exhibited a 6.4-fold higher cellular uptake...
May 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28524069/helical-plant-viral-nanoparticles-bioinspired-synthesis-of-nanomaterials-and-nanostructures
#5
Kannan Badri Narayanan, Sung Soo Han
Viral nanotechnology is revolutionizing the biomimetic and bioinspired synthesis of novel nanomaterials. Bottom-up nanofabrication by self-assembly of individual molecular components of elongated viral nanoparticles (VNPs) and virus-like particles (VLPs) has resulted in the production of superior materials and structures in the nano(bio)technological fields. Viral capsids are attractive materials, because of their symmetry, monodispersity, and polyvalency. Helical VNPs/VLPs are unique prefabricated nanoscaffolds with large surface area to volume ratios and high aspect ratios, and enable the construction of exquisite supramolecular nanostructures...
May 19, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28520407/controlling-configurational-isomerism-in-three-component-colloidal-hybrid-nanoparticles
#6
James M Hodges, Raymond E Schaak
Colloidal hybrid nanoparticles are solution-dispersible constructs that join together multiple distinct nanoscale materials through direct solid-solid interfaces. Given their multifunctionality and synergistic properties that emerge from interfacial coupling, hybrid nanoparticles are of interest for applications in biomedical imaging, solar energy conversion, heterogeneous catalysis, nanophotonics, and beyond. High-order hybrid nanoparticles, which incorporate three or more nanocrystal domains, offer greater tunability and functional diversity relative to one or two-component nanoparticles...
May 18, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28508857/controlling-photophysical-properties-of-ultrasmall-conjugated-polymer-nanoparticles-through-polymer-chain-packing
#7
Hubert Piwoński, Tsuyoshi Michinobu, Satoshi Habuchi
Applications of conjugated polymer nanoparticles (Pdots) for imaging and sensing depend on their size, fluorescence brightness and intraparticle energy transfer. The molecular design of conjugated polymers (CPs) has been the main focus of the development of Pdots. Here we demonstrate that proper control of the physical interactions between the chains is as critical as the molecular design. The unique design of twisted CPs and fine-tuning of the reprecipitation conditions allow us to fabricate ultrasmall (3...
May 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28501673/chemotherapeutic-drug-photothermal-agent-co-self-assembling-nanoparticles-for-near-infrared-fluorescence-and-photoacoustic-dual-modal-imaging-guided-chemo-photothermal-synergistic-therapy
#8
Yang Li, Guihua Liu, Jinyuan Ma, Jinyan Lin, Huirong Lin, Guanghao Su, Dengyue Chen, Shefang Ye, Xiaoyuan Chen, Xuan Zhu, Zhenqing Hou
Multimodal imaging-guided synergistic combination therapy has shown great potential for cancer treatment. However, the nanocarrier-based theranostic systems suffer from batch-to-batch variation, complexity of multicomponent, poor drug loading, and carrier-related toxicity issues. To address these issues, herein we developed a novel carrier-free theranostic system with nanoscale characteristics for near-infrared fluorescence (NIRF) and photoacoustic (PA) dual-modal imaging-guided synergistic chemo-photothermal therapy (PTT)...
May 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28501157/ph-triggered-disaggregation-induced-emission-die-probe-for-sensoring-minor-ph-changes-in-near-infrared-fluorescence-region
#9
Titao Jing, Lifeng Yan
A new strategy for pH-responsive near infrared (NIR) cyanine dye, based on the concept of triggered disaggregation-induced emission (DIE), has been developed. Schiff base group was introduced to the molecular scaffold of Cy7, and promoted the aggregation of cyanine in pH7.4 buffer due to the strong π-π interaction. While in an acidic (pH 5.8) environment, the Schiff base group was hydrolyzed by acid and the nanoparticles were disaggregated. The vanishing of the intermolecular aggregation-caused quenching thus induced a fluorescence recovery of 96 folds...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28499604/iron-oxide-nanoparticles-in-vivo-in-vitro-biomedical-applications-and-in-silico-studies
#10
REVIEW
Miroslava Nedyalkova, Borjana Donkova, Julia Romanova, George Tzvetkov, Sergio Madurga, Vasil Simeonov
The review presents a broad overview of the biomedical applications of surface functionalized iron oxide nanoparticles (IONPs) as magnetic resonance imaging (MRI) agents for sensitive and precise diagnosis tool and synergistic combination with other imaging modalities. Then, the recent progress in therapeutic applications, such as hyperthermia is discussed and the available toxicity data of magnetic nanoparticles concerning in vitro and in vivo biomedical applications are addressed. This review also presents the available computer models using molecular dynamics (MD), Monte Carlo (MC) and density functional theory (DFT), as a basis for a complete understanding of the behaviour and morphology of functionalized IONPs, for improving NPs surface design and expanding the potential applications in nanomedicine...
May 3, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28496321/development-of-99m-tc-radiolabeled-nanosilica-for-targeted-detection-of-her2-positive-breast-cancer
#11
Paolo Rainone, Benedetta Riva, Sara Belloli, Francesco Sudati, Marilena Ripamonti, Paolo Verderio, Miriam Colombo, Barbara Colzani, Maria Carla Gilardi, Rosa Maria Moresco, Davide Prosperi
The human epidermal growth factor receptor 2 (HER2) is normally associated with a highly aggressive and infiltrating phenotype in breast cancer lesions with propensity to spread into metastases. In clinic, the detection of HER2 in primary tumors and in their metastases is currently based on invasive methods. Recently, nuclear molecular imaging techniques, including positron emission tomography and single photon emission computed tomography (SPECT), allowed the detection of HER2 lesions in vivo. We have developed a (99m)Tc-radiolabeled nanosilica system, functionalized with a trastuzumab half-chain, able to act as drug carrier and SPECT radiotracer for the identification of HER2-positive breast cancer cells...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28492333/self-assembly-of-amphiphilic-biotransesterified-%C3%AE-cyclodextrins-supramolecular-structure-of-nanoparticles-and-surface-properties
#12
Jean-Luc Putaux, Christine Lancelon-Pin, Francois-Xavier Legrand, Marion Pastrello, Luc Choisnard, Annabelle Geze, Cyrille Rochas, Denis Wouessidjewe
A series of β-cyclodextrin (βCD) amphiphilic derivatives with varying degree of substitution was prepared by acylating βCDs on their secondary face using thermolysin to catalyze the transesterification. After dissolution in acetone, the βCD-Cn derivatives (n = 8, 10, 12, 14) were nanoprecipitated in water where they self-organized into structured particles which were characterized using cryo-transmission electron microscopy (cryo-TEM) images and small-angle X-ray scattering (SAXS) data. Two types of morphologies and ultrastructures were observed depending on the total degree of substitution (TDS) of the parent derivative...
May 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28487935/folate-receptor-targeted-ultrasonic-pfob-nanoparticles-synthesis-characterization-and-application-in-tumor-targeted-imaging
#13
Keshi Li, Yahui Liu, Shengmin Zhang, Youfeng Xu, Jianshuai Jiang, Fengying Yin, Yue Hu, Baosan Han, Shuxiong Ge, Li Zhang, Yong Wang
In this study, we aimed to determine an effective strategy for the synthesis of folate receptor (FR) targeted-nanoparticles (FRNPs). The nanoparticles used as ultrasound contrast agents (UCAs) were composed of a liquid core of perfluorooctyl bromide (PFOB) liposome and a targeted shell chemically conjugated with folic acid (FA) and polyethylene glycol (PEG). This was done in order to avoid recognition and clearance by the mononuclear phagocyte system [also known as the reticuloendothelial system (RES)] and enhance the targeting capability of the nanoparticles to tumors overexpressing folate receptor (FR)...
June 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28487316/atheroma-susceptible-to-thrombosis-exhibit-impaired-endothelial-permeability-in-vivo-as-assessed-by-nanoparticle-based-fluorescence-molecular-imaging
#14
Ashley F Stein-Merlob, Tetsuya Hara, Jason R McCarthy, Adam Mauskapf, James A Hamilton, Vasilis Ntziachristos, Peter Libby, Farouc A Jaffer
BACKGROUND: The role of local alterations in endothelial functional integrity in atherosclerosis remains incompletely understood. This study used nanoparticle-enhanced optical molecular imaging to probe in vivo mechanisms involving impaired endothelial barrier function in experimental atherothrombosis. METHODS AND RESULTS: Atherosclerosis was induced in rabbits (n=31) using aortic balloon injury and high-cholesterol diet. Rabbits received ultrasmall superparamagnetic iron oxide nanoparticles (CLIO) derivatized with a near-infrared fluorophore (CyAm7) 24 hours before near-infrared fluorescence imaging...
May 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28485601/hyaluronan-inorganic-nanohybrid-materials-for-biomedical-applications
#15
Zhixiang Cai, Hongbin Zhang, Yue Wei, Fengsong Cong
Nanomaterials, including gold, silver and magnetic nanoparticles, carbon and mesoporous materials, possess unique physiochemical and biological properties thus offering promising applications in biomedicine, such as in drug delivery, biosensing, molecular imaging and therapy. Recent advances in nanotechnology have improved the features and properties of nanomaterials. However, these nanomaterials are potentially cytotoxic and demonstrate lack of cell-specific function. Thus, they have been functionalized with various polymers, especially polysaccharides, to reduce toxicity, improve biocompatibility and stability under physiological conditions...
May 9, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28470934/lanthanide-complexes-in-molecular-magnetic-resonance-imaging-and-theranostics
#16
Eva Toth, Sara Lacerda
Lanthanide complexes have attracted continuous attention in the biomedical field and today various imaging applications make use of their versatile magnetic and luminescence properties. In this minireview, we give insights into the mechanistic aspects that allow modulating the relaxation or chemical exchange saturation transfer (CEST) features, thus the MRI efficiency of paramagnetic lanthanide chelates in order to create agents that are capable of providing an MRI response as a function of a specific biomarker...
May 4, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28468365/localization-accuracy-of-gold-nanoparticles-in-single-particle-orientation-and-rotational-tracking
#17
Fei Zhao, Kuangcai Chen, Bin Dong, Kai Yang, Yan Gu, Ning Fang
The Single Particle Orientation and Rotational Tracking (SPORT) technique, which utilizes anisotropic plasmonic gold nanorods and differential interference contrast (DIC) microscopy, has shown potential as an effective alternative to fluorescence-based techniques to decipher rotational motions on the cellular and molecular levels. However, localizing gold nanorods from their DIC images with high accuracy and precision is more challenging than the procedures applied in fluorescence or scattering microscopy techniques due to the asymmetric DIC point spread function with bright and dark parts superimposed over a grey background...
May 1, 2017: Optics Express
https://www.readbyqxmd.com/read/28463506/locating-reactive-groups-on-nanomaterials-with-gold-nanoclusters-toward-a-surface-reactive-site-map
#18
Steffi S Thomas, Matthew Coleman, Emma Carroll, Ester Polo, Fabian Meder, Kenneth A Dawson
Nanoparticles (NPs) are often functionalized with reactive groups such as amines and thiols for the subsequent conjugation of further molecules, e.g., stabilizing polymers, drugs, and proteins for targeting cells or specific diseases. In addition to the quantitative estimation of the reactive conjugation sites, their molecular positioning and nanoscale arrangement on single nanoparticles become more and more important for the tailored engineering and design of functional nanomaterials. Here, we use maleimide or sulfo-succinimidyl ester-modified 1...
May 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28460609/application-of-plasmonic-gold-nanoparticle-for-drug-delivery-system
#19
Jin-Ho Lee, Jeong-Woo Choi
Various kinds of colloidal nanoparticles (NPs) have been widely developed as a promising theranostic probe in biomedical fields. Particularly, colloidal gold nanoparticle (GNP) have been extensively utilized as theranostic probe for molecular imaging and drug delivery owing to their unique physiochemical properties with excellent biocompatibility. This review will outline the progress along this line and discuss about gold nanoparticle synthesis method for controlled geometry (spherical, rod and cage), surface functionalization (covalent and non-covalent) and associated in vitro/in vivo cytotoxicity as well as some of interesting diagnostic (imaging) and therapeutic (photo-thermal, drug delivery) applications...
April 27, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28456728/paclitaxel-loaded-magnetic-nanoparticles-synthesis-characterization-and-application-in-targeting
#20
Jilai Tian, Caiyun Yan, Kunliang Liu, Juan Tao, Zhenchao Guo, Jianping Liu, Yu Zhang, Fei Xiong, Ning Gu
Magnetic iron oxide nanoparticles (MNPs) are good candidates to implement fluid therapy in critically patients in clinic integrated system. Herein, we synthesized paclitaxel loaded MNPs modified with mPEG-Lys-OA2 (PTX-MNPs-PLO), which is expected to act as a magnetic resonance imaging (MRI) contrast agent and meanwhile for cancer therapy. MNPs were synthesized by thermal decomposition. Dialysis method was applied to prepare PTX-MNPs-PLO with three different PEG molecular weights (1000, 2000, and 4000 Da) which were subsequently freeze-dried into powders...
April 26, 2017: Journal of Pharmaceutical Sciences
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