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Nanoparticles and molecular imaging

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https://www.readbyqxmd.com/read/29902593/bone-matrix-development-in-steroid-induced-osteoporosis-is-associated-with-a-consistently-reduced-fibrillar-stiffness-linked-to-altered-bone-mineral-quality
#1
L Xi, P De Falco, E Barbieri, A Karunaratne, L Bentley, C T Esapa, N J Terrill, S D M Brown, R D Cox, G R Davis, N M Pugno, R V Thakker, H S Gupta
Glucocorticoid-induced osteoporosis (GIOP) is a major secondary form of osteoporosis, with the fracture risk significantly elevated - at similar levels of bone mineral density - in patients taking glucocorticoids compared with non-users. The adverse bone structural changes at multiple hierarchical levels in GIOP, and their mechanistic consequences leading to reduced load-bearing capacity, are not clearly understood. Here we combine experimental X-ray nanoscale mechanical imaging with analytical modelling of the bone matrix mechanics to determine mechanisms causing bone material quality deterioration during development of GIOP...
June 11, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29899956/a-self-assembling-luminescent-lanthanide-molecular-nanoparticle-with-potential-for-live-cell-imaging
#2
Xiaoping Yang, Shiqing Wang, Yali Zhang, Guang Liang, Ting Zhu, Lijie Zhang, Shaoming Huang, Desmond Schipper, Richard A Jones
Four luminescent 32-metal Cd-Tb nanoclusters, [Tb8 Cd24 (L1 )12 (OAc)48 ] ( 1 ), [Tb8 Cd24 (L2 )12 (OAc)48 ] ( 2 ), [Tb8 Cd24 (L3 )12 (OAc)48 ] ( 3 ) and [Tb8 Cd24 (L2 )12 (1,4-BDC)4 (OAc)38 (OH)2 ] ( 4 ), were constructed from three specially designed chain-like Schiff base ligands H2 L1-3 with flexible carbon-carbon backbones containing 5, 6 and 10 methylene units, respectively. The clusters exhibit drum-like structures and can be imaged using transmission electron microscopy (TEM). In addition to the Schiff base ligands (the primary energy transfer donors), four 1,4-BDC bridging units were successfully introduced into the structure of 4 ...
May 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29896383/electrochemical-impedance-spectroscopy-of-single-au-nanorods
#3
Tao Liu, Meng Li, Yongjie Wang, Yimin Fang, Wei Wang
We propose monochromatic dark-field imaging microscopy (DFM) to measure the non-faradaic electrochemical impedance spectroscopy (EIS) of single Au nanorods (AuNRs). DFM was utilized to monitor the plasmonic scattering of monochromatic incident light by surface-immobilized individual AuNRs. When modulating the surface potential at a certain frequency, non-faradaic charging and discharging of AuNRs altered their electron density, leading to periodical fluctuations in the scattering intensity. Analysis of the amplitude and phase of the optical intensity fluctuation as a function of modulation frequency resulted in the EIS of single AuNRs...
May 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29894936/cationic-polyacrylamide-induced-nanoparticles-assembly-in-a-cellulose-nanofiber-network
#4
Vikram Singh Raghuwanshi, Uthpala Manavi Garusinghe, Praveena Raj, Nigel Kirby, Armin Hoell, Warren Batchelor, Gil Garnier
Polyacrylamides of different molecular weight, charges and dosages allow to control the retention and distribution of nanoparticles (NPs) in composites, and optimise composite properties and functionality. Our aim is to evaluate the effect of high molecular weight (13 MDa) cationic polyacrylamide (CPAM) charge and dosage on SiO2 (74 nm) NP's assembly in cellulose nanofibers composites. Engineered cellulose/SiO2 composites were investigated by SEM, SAXS and DLS. SEM images show the local area retention of NPs into the cellulose matrix...
June 5, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29890977/nanotechnology-a-promising-method-for-oral-cancer-detection-and-diagnosis
#5
REVIEW
Xiao-Jie Chen, Xue-Qiong Zhang, Qi Liu, Jing Zhang, Gang Zhou
Oral cancer is a common and aggressive cancer with high morbidity, mortality, and recurrence rate globally. Early detection is of utmost importance for cancer prevention and disease management. Currently, tissue biopsy remains the gold standard for oral cancer diagnosis, but it is invasive, which may cause patient discomfort. The application of traditional noninvasive methods-such as vital staining, exfoliative cytology, and molecular imaging-is limited by insufficient sensitivity and specificity. Thus, there is an urgent need for exploring noninvasive, highly sensitive, and specific diagnostic techniques...
June 11, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29890364/oxygen-boosted-immunogenic-photodynamic-therapy-with-gold-nanocages-manganese-dioxide-to-inhibit-tumor-growth-and-metastases
#6
Ruijing Liang, Lanlan Liu, Huamei He, Zhikuan Chen, Zhiqun Han, Zhenyu Luo, Zhihao Wu, Mingbing Zheng, Yifan Ma, Lintao Cai
Metastatic triple-negative breast cancer (mTNBC) is an aggressive disease among women worldwide, characterized by high mortality and poor prognosis despite systemic therapy with radiation and chemotherapies. Photodynamic therapy (PDT) is an important strategy to eliminate the primary tumor, however its therapeutic efficacy against metastases and recurrence is still limited. Here, we employed a template method to develop the core-shell gold nanocage@manganese dioxide (AuNC@MnO2 , AM) nanoparticles as tumor microenvironment responsive oxygen producers and near-infrared (NIR)-triggered reactive oxygen species (ROS) generators for oxygen-boosted immunogenic PDT against mTNBC...
May 31, 2018: Biomaterials
https://www.readbyqxmd.com/read/29890268/hyaluronic-acid-formulation-of-near-infrared-fluorophores-optimizes-surgical-imaging-in-a-prostate-tumor-xenograft
#7
Joshua J Souchek, Nicholas E Wojtynek, William M Payne, Megan B Holmes, Samikshan Dutta, Bowen Qi, Kaustubh Datta, Chad A LaGrange, Aaron M Mohs
The presence of positive surgical margins confers an increased risk of biochemical relapse and need for salvage therapy in men undergoing radical prostatectomy. Image-guided surgery using near-infrared (NIR) fluorescent contrast agents is a potential method to detect remaining cancerous tissue. The objective of this study was to evaluate three hyaluronic acid (HA) nanoparticle (NP) formulations loaded with NIR fluorophore for their ability to contrast-enhance prostate cancer. HA was modified by conjugation with the hydrophobic ligand, aminopropyl-1-pyrenebutanamide to drive nanoparticle self-assembly...
June 8, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29882932/leveraging-engineering-of-indocyanine-green-encapsulated-polymeric-nanocomposites-for-biomedical-applications
#8
REVIEW
Ya-Hui Han, Ranjith Kumar Kankala, Shi-Bin Wang, Ai-Zheng Chen
In recent times, photo-induced therapeutics have attracted enormous interest from researchers due to such attractive properties as preferential localization, excellent tissue penetration, high therapeutic efficacy, and minimal invasiveness, among others. Numerous photosensitizers have been considered in combination with light to realize significant progress in therapeutics. Along this line, indocyanine green (ICG), a Food and Drug Administration (FDA)-approved near-infrared (NIR, >750 nm) fluorescent dye, has been utilized in various biomedical applications such as drug delivery, imaging, and diagnosis, due to its attractive physicochemical properties, high sensitivity, and better imaging view field...
May 24, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29881674/surface-enhanced-raman-nanoparticles-for-tumor-theranostics-applications
#9
REVIEW
Yangyang Li, Qiaolin Wei, Fei Ma, Xin Li, Fengyong Liu, Min Zhou
Raman spectroscopy, amplified by surface-enhanced Raman scattering (SERS) nanoparticles, can provide an in vivo imaging modality due to its high molecular specificity, high sensitivity, and negligible autofluorescence. The basis, composition, and methodologies developed for SERS nanoparticles are herein described. The research hotspots that are the focus in this paper are tumor imaging-guided theranostics and biosensing. The next breakthrough may be the development of biocompatible SERS nanoparticles and spectroscopic devices for clinical applications...
May 2018: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29879168/extracellular-mrna-detected-by-molecular-beacons-in-tethered-lipoplex-nanoparticles-for-diagnosis-of-human-hepatocellular-carcinoma
#10
Xinmei Wang, Kwang Joo Kwak, Zhaogang Yang, Aili Zhang, Xiaoli Zhang, Rachael Sullivan, Dan Lin, Robert L Lee, Carlos Castro, Kalpana Ghoshal, Carl Schmidt, L James Lee
Hepatocellular carcinoma (HCC) remains one of the major causes of cancer related deaths. Although ultrasonography (US), computed tomography (CT) and/or high-cost magnetic resonance imaging (MRI) have been shown to improve early detection of liver cancer and mortality rates in high-risk individuals, such imaging based methods are limited by high rates of false positivity leading to unnecessary patient anxiety and invasive procedures. Complementary blood biomarkers could increase the accuracy of early detection...
2018: PloS One
https://www.readbyqxmd.com/read/29873658/au-25-sr-18-the-captain-of-the-great-nanocluster-ship
#11
REVIEW
Xi Kang, Hanbao Chong, Manzhou Zhu
Noble metal nanoclusters are in the intermediate state between discrete atoms and plasmonic nanoparticles and are of significance due to their atomically accurate structures, intriguing properties, and great potential for applications in various fields. In addition, the size-dependent properties of nanoclusters construct a platform for thoroughly researching the structure (composition)-property correlations, which is favorable for obtaining novel nanomaterials with enhanced physicochemical properties. Thus far, more than 100 species of nanoclusters (mono-metallic Au or Ag nanoclusters, and bi- or tri-metallic alloy nanoclusters) with crystal structures have been reported...
June 6, 2018: Nanoscale
https://www.readbyqxmd.com/read/29872620/biomimetic-nanoparticles-for-inflammation-targeting
#12
REVIEW
Kai Jin, Zimiao Luo, Bo Zhang, Zhiqing Pang
There have been many recent exciting developments in biomimetic nanoparticles for biomedical applications. Inflammation, a protective response involving immune cells, blood vessels, and molecular mediators directed against harmful stimuli, is closely associated with many human diseases. As a result, biomimetic nanoparticles mimicking immune cells can help achieve molecular imaging and precise drug delivery to these inflammatory sites. This review is focused on inflammation-targeting biomimetic nanoparticles and will provide an in-depth look at the design of these nanoparticles to maximize their benefits for disease diagnosis and treatment...
January 2018: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29869883/atomic-force-microscopy-study-on-stiffness-of-nanosized-liposomes-containing-charged-lipids
#13
Yuki Takechi-Haraya, Yukihiro Goda, Kumiko Sakai-Kato
It has recently been recognized that the mechanical properties of lipid nanoparticles play an important role during in vitro and in vivo behaviors such as cellular uptake, blood circulation, and biodistribution. However, there have been no quantitative investigations of the effect of commonly-used charged lipids on the stiffness of nanosized liposomes. In this study, by means of atomic force microscopy (AFM), we quantified the stiffness of nanosized liposomes composed of neutrally charged lipids combined with positively or negatively charged lipids while simultaneously imaging the liposomes in aqueous medium...
June 5, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29869235/in-planta-production-of-fluorescent-filamentous-plant-virus-based-nanoparticles
#14
Sourabh Shukla, Christina Dickmeis, Rainer Fischer, Ulrich Commandeur, Nicole F Steinmetz
Viral nanoparticles are attractive platforms for biomedical applications and are frequently employed for optical imaging in tissue culture and preclinical animal models as fluorescent probes. Chemical modification with organic dyes remains the most common strategy to develop such fluorescent probes. Here we report a genetic engineering approach to incorporate fluorescent proteins in viral nanoparticles, which can be propagated in their plant host. The fluorescent viral nanoparticles so obtained obviate post-harvest modifications and thereby maximize yields...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29858794/synthesis-purification-characterization-and-imaging-of-cy3-functionalized-fluorescent-silver-nanoparticles-in-2d-and-3d-tumor-models
#15
Jessica Swanner, Ravi Singh
Silver nanoparticles (AgNPs) have a high affinity for sulfhydryl (thiol) groups, which can be exploited for functionalization with various tracking and targeting moieties. Here, we describe how to reliably and reproducibly functionalize AgNPs with the fluorescent moiety cyanine3-polyethelyne glycol (5000 molecular weight)-thiol (Cy3-PEG5000 -SH). We also demonstrate how to purify and characterize Cy3-functionalized AgNPs (Cy3-AgNPs). Additionally, we describe how these Cy3-AgNPs can be imaged in 2D and 3D tumor models, providing insight into cellular localization and diffusion through a tumor spheroid, respectively...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29848256/fluorescent-probes-for-detection-of-protein-from-bench-to-bed
#16
Jing Xiong, Zhaohui Mo, Wei Wang, Xiaozheng Cao, Shuqi Yang, Wenbin Zeng
It is important to quantitatively detect specific analytes for varieties of applications ranging from life sciences to environmental monitoring. Proteins play vital roles in the life system, especially for the evaluation of many diseases. Thus, the quantitative measurement of protein is beneficial for the diagnosis and monitoring of diseases. Among the sensing methods currently developed, fluorescence detection is of particular concern as a technique with the potential to provide accurate and quantitative analyses...
May 30, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29844898/a-highly-integrated-dna-nanomachine-operating-in-living-cells-powered-by-an-endogenous-stimulus
#17
Pei-Qiang Ma, Cheng-Pin Liang, He-Hua Zhang, Bin-Cheng Yin, Bang-Ce Ye
Synthetic molecular machines have received increasing attention because of their great ability to mimic natural biological motors and create novel modes of motion. However, very few examples have been implemented with real autonomous movement inside living cells, due to the challenges of the driving force and highly integrated system design. In this work, we report an elegant, highly integrated DNA nanomachine that can be powered by endogenous ATP molecules and autonomously operated inside living cells without any auxiliary additives...
April 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29808018/nanoparticles-for-super-resolution-microscopy-and-single-molecule-tracking
#18
REVIEW
Dayong Jin, Peng Xi, Baoming Wang, Le Zhang, Jörg Enderlein, Antoine M van Oijen
We review the use of luminescent nanoparticles in super-resolution imaging and single-molecule tracking, and showcase novel approaches to super-resolution imaging that leverage the brightness, stability, and unique optical-switching properties of these nanoparticles. We also discuss the challenges associated with their use in biological systems, including intracellular delivery and molecular targeting. In doing so, we hope to provide practical guidance for biologists and continue to bridge the fields of super-resolution imaging and nanoparticle engineering to support their mutual advancement...
May 28, 2018: Nature Methods
https://www.readbyqxmd.com/read/29806163/maximizing-aggregation-of-organic-fluorophores-to-prolong-fluorescence-lifetime-for-two-photon-fluorescence-lifetime-imaging
#19
Wenbo Hu, Lihong Guo, Lei Bai, Xiaofei Miao, Yun Ni, Qi Wang, Hui Zhao, Meng Xie, Lin Li, Xiaomei Lu, Wei Huang, Quli Fan
Two-photon fluorescence lifetime imaging (TP-FLIM) not only permits imaging deep inside the tissues with precise spatial manipulation but also circumvents tissue autofluorescence, holding tremendous promise in molecular imaging. However, the serious lack of suitable contrast agents with long fluorescence lifetime and efficient two-photon absorption (TPA) greatly limits the advance of TP-FLIM. This study reports a simple approach to fabricate water-soluble organic semiconducting nanoparticles [thioxanthone (TXO) NPs] with ultralong fluorescence lifetime and efficient TPA for in vivo TP-FLIM...
May 28, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29802849/a-preliminary-study-of-photoacoustic-ultrasound-dual-mode-imaging-in-melanoma-using-mage-targeted-gold-nanoparticles
#20
Xuelin Li, Dong Wang, Haitao Ran, Lan Hao, Yang Cao, Meng Ao, Nan Zhang, Jiao Song, Liang Zhang, Hengjing Yi, Zhigang Wang, Pan Li
Nanoprobes are small enough to circulate within the vasculature and can reach tumour tissues through the endothelial gap, providing a new strategy for accurate tumour monitoring and imaging-guided antitumour therapy at the molecular level. Both photoacoustic and ultrasonic imaging are noninvasive tools for cancer detection via the application of nanoprobes. In this study, a polymeric multifunctional nanoparticle probe loaded with gold nanorods (Au-NRs) and liquid perfluorocarbon (perfluorinated hexane/PFH) and conjugated to a monoclonal antibody (MAGE-1 antibody) to melanoma-associated antigens (MAGE) targeting melanoma was successfully prepared by the double emulsion and carbodiimide methods as a targeted photoacoustic/ultrasound dual-mode imaging contrast agent (MAGE-Au-PFH-NPs)...
May 24, 2018: Biochemical and Biophysical Research Communications
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