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Nanoparticles and molecular imaging

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https://www.readbyqxmd.com/read/28212271/carbon-nanotubes-as-an-effective-opportunity-for-cancer-diagnosis-and-treatment
#1
REVIEW
Alessandro Sanginario, Beatrice Miccoli, Danilo Demarchi
Despite the current progresses of modern medicine, the resistance of malignant tumors to present medical treatments points to the necessity of developing new therapeutic approaches. In recent years, numerous studies have focused their attention on the promising use of nanomaterials, like iron oxide nanowires, zinc oxide or mesoporous silica nanoparticles, for cancer and metastasis treatment with the advantage of operating directly at the bio-molecular scale. Among them, carbon nanotubes emerged as valid candidates not only for drug delivery, but also as a valuable tool in cancer imaging and physical ablation...
February 15, 2017: Biosensors
https://www.readbyqxmd.com/read/28208719/micro-computed-tomography-detection-of-gold-nanoparticle-labelled-mesenchymal-stem-cells-in-the-rat-subretinal-layer
#2
Pooi Ling Mok, Sue Ngein Leow, Avin Ee-Hwan Koh, Hairul Harun Mohd Nizam, Suet Lee Shirley Ding, Chi Luu, Raduan Ruhaslizan, Hon Seng Wong, Wan Haslina Wan Abdul Halim, Min Hwei Ng, Ruszymah Binti Hj Idrus, Shiplu Roy Chowdhury, Catherine Mae-Lynn Bastion, Suresh Kumar Subbiah, Akon Higuchi, Abdullah A Alarfaj, Kong Yong Then
Mesenchymal stem cells are widely used in many pre-clinical and clinical settings. Despite advances in molecular technology; the migration and homing activities of these cells in in vivo systems are not well understood. Labelling mesenchymal stem cells with gold nanoparticles has no cytotoxic effect and may offer suitable indications for stem cell tracking. Here, we report a simple protocol to label mesenchymal stem cells using 80 nm gold nanoparticles. Once the cells and particles were incubated together for 24 h, the labelled products were injected into the rat subretinal layer...
February 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28198362/covalent-assembly-of-nanoparticles-as-a-peptidase-degradable-platform-for-molecular-mri
#3
Francisco Perez-Balderas, Sander I van Kasteren, Alaa A A Aljabali, Kim Wals, Sébastien Serres, Andrew Jefferson, Manuel Sarmiento Soto, Alexandre A Khrapitchev, James R Larkin, Claire Bristow, Seung Seo Lee, Guillaume Bort, Filippo De Simone, Sandra J Campbell, Robin P Choudhury, Daniel C Anthony, Nicola R Sibson, Benjamin G Davis
Ligand-conjugated microparticles of iron oxide (MPIO) have the potential to provide high sensitivity contrast for molecular magnetic resonance imaging (MRI). However, the accumulation and persistence of non-biodegradable micron-sized particles in liver and spleen precludes their clinical use and limits the translational potential of MPIO-based contrast agents. Here we show that ligand-targeted MPIO derived from multiple iron oxide nanoparticles may be coupled covalently through peptide linkers that are designed to be cleaved by intracellular macrophage proteases...
February 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28194944/achieving-high-spatial-resolution-surface-plasmon-resonance-microscopy-with-image-reconstruction
#4
Hui Yu, Xiaonan Shan, Shaopeng Wang, Nongjian Tao
Surface plasmon resonance microscopy (SPRM) is a powerful platform for biomedical imaging and molecular binding kinetics analysis. However, the spatial resolution of SPRM along the plasmon propagation direction (longitudinal) is determined by the decaying length of the plasmonic wave, which can be as large as tens of microns. Different methods have been proposed to improve the spatial resolution but each at the expense of decreased sensitivity or temporal resolution. Here we present a method to achieve high spatial resolution SPRM based on deconvolution of complex field...
February 8, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28184393/programmable-dna-triple-helix-molecular-switch-in-biosensing-applications-from-in-homogenous-solutions-to-in-living-cells
#5
Pinting Tang, Jing Zheng, Jianru Tang, Dandan Ma, Weijian Xu, Jishan Li, Zhong Cao, Ronghua Yang
Herein, we demonstrated a new gold nanoparticles (AuNPs)-integrated programmable triple-helix molecular switch (THMS) to realize the biosensing of multiple targets from in homogenous solution to in living cells. The results demonstrated that this proposed programmable THMS could be successfully used for imaging multiple messenger RNA (mRNA) in living cells and it significantly extends the scope of the THMS sensing platform.
February 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28179191/photosensitizer-mediated-mitochondria-targeting-nanosized-drug-carriers-subcellular-targeting-therapeutic-and-imaging-potentials
#6
Yeon Su Choi, Kiyoon Kwon, Kwonhyeok Yoon, Kang Moo Huh, Han Chang Kang
Mitochondria-targeting drug carriers have considerable potential because of the presence of many molecular drug targets in the mitochondria and their pivotal roles in cellular viability, metabolism, maintenance, and death. To compare the mitochondria-targeting abilities of triphenylphosphonium (TPP) and pheophorbide a (PhA) in nanoparticles (NPs), this study prepared mitochondria-targeting NPs using mixtures of methoxy poly(ethylene glycol)-(SS-PhA)2 [mPEG-(SS-PhA)2 or PPA] and TPP-b-poly(ε-caprolactone)-b-TPP [TPP-b-PCL-b-TPP or TPCL], which were designated PPAn-TPCL4-n (0≤n≤4) NPs...
February 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28170348/thermal-conductivity-calculation-of-nano-suspensions-using-green-kubo-relations-with-reduced-artificial-correlations
#7
Murali Gopal Muraleedharan, Dilip Sundaram, Asegun Henry, Vigor Yang
The presence of artificial correlations associated with Green-Kubo (GK) thermal conductivity calculations is investigated. The thermal conductivity of nano-suspensions is calculated by equilibrium molecular dynamics (EMD) simulations using GK relations. Calculations are first performed for a single alumina (Al2O3) nanoparticle dispersed in a water medium. For a particle size of 1 nm and volume fraction of 9%, results show enhancements as high as 235%, which is much higher than the Maxwell model predictions...
February 7, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28161576/molecular-assessment-of-collagen-denaturation-in-decellularized-tissues-using-a-collagen-hybridizing-peptide
#8
Jeongmin Hwang, Boi Hoa San, Neill J Turner, Lisa J White, Denver M Faulk, Stephen F Badylak, Yang Li, S Michael Yu
: Decellularized extracellular matrix (ECM) derived from tissues and organs are emerging as important scaffold materials for regenerative medicine. Many believe that preservation of the native ECM structure during decellularization is highly desirable. However, because effective techniques to assess the structural damage in ECM are lacking, the disruptive effects of a decellularization method and the impact of the associated structural damage upon the scaffold's regenerative capacity are often debated...
February 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28153809/nitrite-sensing-composite-systems-based-on-a-core-shell-emissive-superamagnetic-structure-construction-characterization-and-sensing-behavior
#9
Yan Yang, Liang Liu, Jianhua Zha, Ningyi Yuan
Two recyclable nitrite sensing composite samples were designed and constructed through a core-shell structure, with Fe3O4 nanoparticles as core, silica molecular sieve MCM-41 as shell and two rhodamine derivatives as chemosensors, respectively. These samples and their structure were identified with their electron microscopy images, N2 adsorption/desorption isotherms, magnetic response, IR spectra and thermogravimetric analysis. Their nitrite sensing behavior was discussed based on emission intensity quenching, their limit of detection was found as low as 1...
January 26, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28145686/in-situ-characterization-of-protein-adsorption-onto-nanoparticles-by-fluorescence-correlation-spectroscopy
#10
Li Shang, G Ulrich Nienhaus
Nanotechnology holds great promise for applications in many fields including biology and medicine. Unfortunately, the processes occurring at the interface between nanomaterials and living systems are exceedingly complex and not yet well understood, which has significantly hampered the realization of many nanobiotechnology applications. Whenever nanoparticles (NPs) are incorporated by a living organism, a protein adsorption layer, also known as the "protein corona", forms on the NP surface. Accordingly, living organisms interact with protein-coated rather than bare NPs, and their biological responses depend on the nature of the protein corona...
February 1, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28139881/interference-free-surface-enhanced-raman-scattering-tags-for-single-cell-molecular-imaging-with-a-high-signal-to-background-ratio
#11
Sisi Ma, Qiang Li, Yongmei Yin, Jie Yang, Dingbin Liu
An interference-free surface-enhanced Raman scattering tag is constructed to profile the expression of cancer biomarkers at the single-cell level. The Raman tags present a strong and sharp peak in the cellular Raman-silent region, significantly diminishing the background interference. Moreover, the reporters are embedded in the layered gold nanoparticles, avoiding desorption and enzymatic degradation in physiological conditions.
January 31, 2017: Small
https://www.readbyqxmd.com/read/28135067/nanocuvette-a-functional-ultrathin-liquid-container-for-transmission-electron-microscopy
#12
Carl Wadell, Satoshi Inagaki, Tomiro Nakamura, Ji Shi, Yoshio Nakamura, Takumi Sannomiya
Advances in TEM techniques have spurred a renewed interest in a wide variety of research fields. A rather recent track within these endeavors is the use of TEM for in situ imaging in liquids. In this article, we show the fabrication of a liquid cell for TEM observations which we call the nanocuvette. The structure consists of a nanohole film sandwiched by carbon films, sealing liquid in the holes. The hole film can be produced using a variety of materials, tailored for the desired application. Since the fabrication is based on self-assembly, it is both cheap and straightforward...
February 1, 2017: ACS Nano
https://www.readbyqxmd.com/read/28126683/pet-imaging-of-64-cu-dota-scfv-anti-psma-lipid-nanoparticles-lnps-enhanced-tumor-targeting-over-anti-psma-scfv-or-untargeted-lnps
#13
Patty Wong, Lin Li, Junie Chea, Melissa K Delgado, Desiree Crow, Erasmus Poku, Barbara Szpikowska, Nicole Bowles, Divya Channappa, David Colcher, Jeffrey Y C Wong, John E Shively, Paul J Yazaki
INTRODUCTION: Single chain (scFv) antibodies are ideal targeting ligands due to their modular structure, high antigen specificity and affinity. These monovalent ligands display rapid tumor targeting but have limitations due to their fast urinary clearance. METHODS: An anti-prostate membrane antigen (PSMA) scFv with a site-specific cysteine was expressed and evaluated in a prostate cancer xenograft model by Cu-64 PET imaging. To enhance tumor accumulation, the scFv-cys was conjugated to the co-polymer DSPE-PEG-maleimide that spontaneously assembled into a homogeneous multivalent lipid nanoparticle (LNP)...
January 17, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28124549/radiolabeled-inorganic-nanoparticles-for-positron-emission-tomography-imaging-of-cancer-an-overview
#14
Rubel Chakravarty, Shreya Goel, Ashutosh Dash, Weibo Cai
Over the last few years, a plethora of radiolabeled inorganic nanoparticles have been developed and evaluated for their potential use as probes in positron emission tomography (PET) imaging of a wide variety of cancers. Inorganic nanoparticles represent an emerging paradigm in molecular imaging probe design, allowing the incorporation of various imaging modalities, targeting ligands, and therapeutic payloads into a single vector. A major challenge in this endeavor is to develop disease-specific nanoparticles with facile and robust radio labeling strategies...
January 26, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28121134/molecular-imaging-of-vulnerable-atherosclerotic-plaques-in-vivo-with-osteopontin-specific-upconversion-nanoprobes
#15
Ruirui Qiao, Hongyu Qiao, Yan Zhang, Yabin Wang, Chongwei Chi, Jie Tian, Lifang Zhang, Feng Cao, Mingyuan Gao
Owing to the high mortality rate of cardiovascular diseases, developing novel noninvasive diagnostic methods becomes urgent and mandatory. It is well-known that the rupture of vulnerable plaques directly leads to deadly consequences. However, differentiating vulnerable plaques from stable plaques remains challenging in the clinic. In the current study, osteopontin (OPN), a secreted biomarker associated with macrophages and foamy macrophages, was selected as a target for identifying the vulnerable plaques. A dual modality imaging probe was constructed by covalently attaching an OPN antibody to NaGdF4:Yb,Er@NaGdF4 upconversion nanoparticles...
January 31, 2017: ACS Nano
https://www.readbyqxmd.com/read/28115259/biocompatible-polymersomes-based-cancer-theranostics-towards-multifunctional-nanomedicine
#16
REVIEW
Marzieh Mohammadi, Mohammad Ramezani, Khalil Abnous, Mona Alibolandi
Polymersomes are polymeric vesicles that have numerous advantages for theranostics, the integrated approach of therapeutics and diagnostics. Polymersomes possess core- shell structures which encapsulate hydrophilic molecules in the aqueous compartment and hydrophobic molecules in the bilayer of the vesicles. Polymersomes are made of different amphiphilic block copolymers. Thus, in the process of designing polymersomes, a variety of amphiphilic block copolymers with different molecular weights are used to develop intelligent or sustained released formulations and to modify the stability of the system and bilayer thickness or to functionalize the particle with targeting moieties to improve the delivery efficiency...
January 20, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28115248/nanoparticle-mediated-radiopharmaceutical-excited-fluorescence-molecular-imaging-allows-precise-image-guided-tumor-removal-surgery
#17
Zhenhua Hu, Chongwei Chi, Muhan Liu, Hongbo Guo, Zeyu Zhang, Chaoting Zeng, Jinzuo Ye, Jing Wang, Jie Tian, Weidong Yang, Wanhai Xu
Fluorescent molecular imaging technique has been actively explored for optical image-guided cancer surgery in pre-clinical and clinical research and has attracted many attentions. However, the efficacy of the fluorescent image-guided cancer surgery can be compromised by the low signal-to-noise ratio caused by the external light excitation. This study presents a novel nanoparticle-mediated radiopharmaceutical-excited fluorescent (REF) image-guided cancer surgery strategy, which employs the internal dual-excitation of europium oxide nanoparticles through both gamma rays and Cerenkov luminescence emitted from radiopharmaceuticals...
January 20, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28112512/enzyme-sensitive-and-amphiphilic-pegylated-dendrimer-paclitaxel-prodrug-based-nanoparticles-for-enhanced-stability-and-anticancer-efficacy
#18
Ning Li, Hao Cai, Lei Jiang, Jiani Hu, Ashika Bains, Jesse Hu, Qiyong Gong, Kui Luo, Zhongwei Gu
In this study, we prepared a smart polymeric vehicle for the hydrophobic drug paclitaxel (PTX) that allowed a maximum steady-state circulation and a fast intracellular release in tumors. PTX was linked to the Janus PEGylated (PEG = poly(ethylene glycol)) peptide dendrimer via an enzyme-sensitive linker glycylphenylalanylleucylglycine tetrapeptide by efficient click reaction, resulting in Janus dendritic prodrug with 20.9% PTX content. The prodrug self-assembled into nanoscale particles with appropriate nanosizes, compact morphology, and negative surface charge...
February 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28102031/dual-nano-sized-contrast-agents-in-pet-mri-a-systematic-review
#19
REVIEW
Afsaneh Lahooti, Saeed Sarkar, Sophie Laurent, Saeed Shanehsazzadeh
Nowadays molecular imaging plays a vital role in achieving a successful targeted and personalized treatment. Hence, the approach of combining two or more medical imaging modalities was developed. The objective of this review is to systematically compare recent dual contrast agents in Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) and in some cases Single photon emission computed tomography (SPECT)/MRI in terms of some their characteristics, such as tumor uptake, and reticuloendothelial system uptake (especially liver) and their relaxivity rates for early detection of primary cancer tumor...
November 2016: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/28091604/polyglucose-nanoparticles-with-renal-elimination-and-macrophage-avidity-facilitate-pet-imaging-in-ischaemic-heart-disease
#20
Edmund J Keliher, Yu-Xiang Ye, Gregory R Wojtkiewicz, Aaron D Aguirre, Benoit Tricot, Max L Senders, Hannah Groenen, Francois Fay, Carlos Perez-Medina, Claudia Calcagno, Giuseppe Carlucci, Thomas Reiner, Yuan Sun, Gabriel Courties, Yoshiko Iwamoto, Hye-Yeong Kim, Cuihua Wang, John W Chen, Filip K Swirski, Hsiao-Ying Wey, Jacob Hooker, Zahi A Fayad, Willem J M Mulder, Ralph Weissleder, Matthias Nahrendorf
Tissue macrophage numbers vary during health versus disease. Abundant inflammatory macrophages destruct tissues, leading to atherosclerosis, myocardial infarction and heart failure. Emerging therapeutic options create interest in monitoring macrophages in patients. Here we describe positron emission tomography (PET) imaging with (18)F-Macroflor, a modified polyglucose nanoparticle with high avidity for macrophages. Due to its small size, Macroflor is excreted renally, a prerequisite for imaging with the isotope flourine-18...
January 16, 2017: Nature Communications
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