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Nanoparticles and medical imaging

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https://www.readbyqxmd.com/read/28619641/optimal-conditions-for-producing-bactericidal-sodium-hyaluronate-tio2-bionanocomposite-and-its-characterization
#1
Mohsen Safaei, Mojtaba Taran
In this research, the creation of optimum conditions for the formation of sodium hyaluronate-TiO2 bionanocomposite and its antibacterial effect on gram positive and gram negative bacteria was evaluated. The Fourier transform infrared spectroscopy spectra, scanning electron microscopy images and energy dispersive X-ray spectroscopy pattern confirmed the formation of the bionanocomposite. Thermogravimetric analysis and differential thermal analysis indicated that the thermal stability rate had significantly improved with formation of the bionanocomposite...
June 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28609289/adverse-eff-ects-of-polymeric-nanoparticle-poly-ethylene-glycol-block-polylactide-methyl-ether-peg-b-pla-on-steroid-hormone-secretion-by-porcine-granulosa-cells
#2
Sona Scsukova, Mlynarcikova A Bujnakova, A Kiss, E Rollerova
OBJECTIVES: Development of nanoparticles (NPs) for biomedical applications, including medical imaging and drug delivery, is currently undergoing a dramatic expansion. Diverse effects of different type NPs relating to mammalian reproductive tissues have been demonstrated. Th e objective of this study was to explore the in vitro effects of polymeric nanoparticle poly(ethylene glycol)-blockpolylactide methyl ether (PEG-b-PLA NPs) on functional state and viability of ovarian granulosa cells (GCs), which play an important role in maintaining ovarian function and female fertility...
April 25, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/28607443/size-tunable-lateral-confinement-in-monolayer-semiconductors
#3
Guohua Wei, David A Czaplewski, Erik J Lenferink, Teodor K Stanev, Il Woong Jung, Nathaniel P Stern
Three-dimensional confinement allows semiconductor quantum dots to exhibit size-tunable electronic and optical properties that enable a wide range of opto-electronic applications from displays, solar cells and bio-medical imaging to single-electron devices. Additional modalities such as spin and valley properties in monolayer transition metal dichalcogenides provide further degrees of freedom requisite for information processing and spintronics. In nanostructures, however, spatial confinement can cause hybridization that inhibits the robustness of these emergent properties...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28603606/synthesis-and-properties-of-magnetic-optical-core-shell-nanoparticles
#4
Elyahb Allie Kwizera, Elise Chaffin, Yongmei Wang, Xiaohua Huang
Due to their high integrity, facile surface chemistry, excellent stability, and dual properties from the core and shell materials, magnetic-plasmonic core-shell nanoparticles are of great interest across a number of science, engineering and biomedical disciplines. They are promising for applications in a broad range of areas including catalysis, energy conversion, biological separation, medical imaging, disease detection and treatment. The technological applications have driven the need for high quality nanoparticles with well controlled magnetic and optical properties...
March 19, 2017: RSC Advances
https://www.readbyqxmd.com/read/28602801/raman-imaging-of-cellular-uptake-and-studies-of-silver-nanoparticles-effect-in-bj-human-fibroblasts-cell-lines
#5
Monika Perlovska Harvanova, Jana Jiravova, Jakub Malohlava, Katerina Barton Tomankova, Dagmar Jirova, Hana Kolarova
Silver nanoparticles (AgNPs) have been widely studied for their beneficial antimicrobial effect and have been considered by some to be a safe ingredient, as penetration of metal nanoparticles through the skin in vivo has not been proven. However, AgNPs are becoming a commonly applied nanomaterial for surface modifications of medical products which come into contact with damaged skin. In our experiments, we tested two commercially available AgNPs samples manufactured by electrolysis. AFM was used to characterize tested AgNPs morphology and their mean particle size which was assessed as 30...
June 7, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28596141/delivery-of-cyclodextrin-polymers-to-bacterial-biofilms-an-exploratory-study-using-rhodamine-labelled-cyclodextrins-and-multiphoton-microscopy
#6
Hanna Thomsen, Gábor Benkovics, Éva Fenyvesi, Anne Farewell, Milo Malanga, Marica B Ericson
Cyclodextrin (CD) polymers are interesting nanoparticulate systems for pharmaceutical delivery; however, knowledge regarding their applications towards delivery into complex microbial biofilm structures is so far limited. The challenge is to demonstrate penetration and transport through the biofilm and its exopolysaccharide matrix. The ideal functionalization for penetration into mature biofilms is unexplored. In this paper, we present a novel set of rhodamine labelled βCD-polymers, with different charge moieties, i...
June 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28595565/gold-nanoparticles-by-laser-ablation-for-x-ray-imaging-and-protontherapy-improvements
#7
Torrisi Lorenzo, Nancy Restuccia, Irene Paterniti
Gold nanoparticles, 5-20 nm in diameter, were generated with a pulsed Nd:YAG laser at 1010 W/cm2 at solution concentrations ranging between 1-100 mg/ml. Nanoparticles were characterized using optical absorbance, X-ray fluorescence, SEM, and TEM. Biocompatible nanoparticle solutions were injected by intravenously into the tail veins of mice followed by X-ray imaging using 20-45 keV photons to evaluate the uptake and the clearance by different organs of the nanoparticles. The incremental X-ray contrast imaging using gold nanoparticles was investigated and measured...
June 8, 2017: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/28593942/dynamic-contrast-enhanced-photoacoustic-imaging-using-photothermal-stimuli-responsive-composite-nanomodulators
#8
Yun-Sheng Chen, Soon Joon Yoon, Wolfgang Frey, Mary Dockery, Stanislav Emelianov
Molecular photoacoustic imaging has shown great potential in medical applications; its sensitivity is normally in pico-to-micro-molar range, dependent on exogenous imaging agents. However, tissue can produce strong background signals, which mask the signals from the imaging agents, resulting in orders of magnitude sensitivity reduction. As such, an elaborate spectral scan is often required to spectrally un-mix the unwanted background signals. Here we show a new single-wavelength photoacoustic dynamic contrast-enhanced imaging technique by employing a stimuli-responsive contrast agent...
June 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28589558/potential-applications-and-human-biosafety-of-nanomaterials-used-in-nanomedicine
#9
REVIEW
Hong Su, Yafei Wang, Yuanliang Gu, Linda Bowman, Jinshun Zhao, Min Ding
With the rapid development of nanotechnology, potential applications of nanomaterials in medicine have been widely researched in recent years. Nanomaterials themselves can be used as image agents or therapeutic drugs, and for drug and gene delivery, biological devices, nanoelectronic biosensors or molecular nanotechnology. As the composition, morphology, chemical properties, implant sites as well as potential applications become more and more complex, human biosafety of nanomaterials for clinical use has become a major concern...
June 6, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28579780/aggregation-is-a-critical-cause-of-poor-transfer-into-the-brain-tissue-of-intravenously-administered-cationic-pamam-dendrimer-nanoparticles
#10
Yoshika Kurokawa, Hideko Sone, Tin-Tin Win-Shwe, Yang Zeng, Hiroyuki Kimura, Yosuke Koyama, Yusuke Yagi, Yasuto Matsui, Masashi Yamazaki, Seishiro Hirano
Dendrimers have been expected as excellent nanodevices for brain medication. An amine-terminated polyamidoamine dendrimer (PD), an unmodified plain type of PD, has the obvious disadvantage of cytotoxicity, but still serves as an attractive molecule because it easily adheres to the cell surface, facilitating easy cellular uptake. Single-photon emission computed tomographic imaging of a mouse following intravenous injection of a radiolabeled PD failed to reveal any signal in the intracranial region. Furthermore, examination of the permeability of PD particles across the blood-brain barrier (BBB) in vitro using a commercially available kit revealed poor permeability of the nanoparticles, which was suppressed by an inhibitor of caveolae-mediated endocytosis, but not by an inhibitor of macropinocytosis...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28565928/iron-oxide-magnetic-nanoparticles-as-antimicrobials-for-therapeutics
#11
Lucas de Alcântara Sica de Toledo, Hélen Cássia Rosseto, Marcos Luciano Bruschi
The use of iron oxide magnetic nanoparticles (IMNP) in medical and pharmaceutical areas dates to the beginning of the 1970s, as carriers. Some other uses to these nanoparticles are in vitro separation, magnetic resonance imaging and drug targeting agent. Many preparations containing IMNP have been described and used in drug delivery, hyperthermia, in vitro separation, tissue repair, cellular therapy, for magnetic separation, magnetic resonance imaging, as spoilers for magnetic resonance spectroscopy, and more recently as sensors for metabolites and other biomolecules...
June 21, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28564489/graphene-oxide-ag-nanoparticles-cooperated-with-simvastatin-as-a-high-sensitive-x-ray-computed-tomography-imaging-agent-for-diagnosis-of-renal-dysfunctions
#12
Zhan Li, Longlong Tian, Jianli Liu, Wei Qi, Qiang Wu, Haijing Wang, Mohammad Chand Ali, Wangsuo Wu, Hongdeng Qiu
Graphene oxides (GO) are attracting much attention in the diagnosis and therapy of the subcutaneous tumor as a novel biomaterial, but its diagnosis to tissue dysfunction is yet to be found. Here, a novel application of GO for diagnosis of renal dysfunction via contrast-enhanced computed tomography (CT) is proposed. In order to serve as contrast-enhanced agent, Ag nanoparticles (AgNPs) are composited on the surface of GO to promote its X-ray absorption, and then simvastatin is coinjected for eliminating in vivo toxicity induced by AgNPs...
May 31, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28541741/green-approach-for-synthesis-of-gold-nanoparticles-from-nigella-arvensis-leaf-extract-and-evaluation-of-their-antibacterial-antioxidant-cytotoxicity-and-catalytic-activities
#13
Azam Chahardoli, Naser Karimi, Fatemeh Sadeghi, Ali Fattahi
In the present work, we studied the reduction of gold ions into gold nanoparticles using Nigella arvensis leaf extract in the one-step green synthesis method. The formation of N. arvensis gold nanoparticles (NA-GNPs) was confirmed by UV-Vis spectroscopy, XRD, FT-IR and TEM analyses. The XRD pattern confirmed the crystal structure of NA-GNPs, and TEM image showed the small size (3-37 nm) and almost spherical shape of NA-GNPs. NA-GNPs have not shown enhanced antioxidant properties compared to the plant extract while they were active against the clinical isolated bacterial strains...
May 25, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28530195/facile-synthesis-of-silver-nanoparticles-mediated-by-polyacrylamide-reduction-approach-to-antibacterial-application
#14
Hosam I Salaheldin, Meshal H K Almalki, Abd Elhameed M Hezma, Gamal E H Osman
The current time increase in the prevalence of antibiotic resistant 'super-bugs' and the risks associated with food safety have become global issues. Therefore, further research is warranted to identify new and effective antimicrobial substances. Silver nanoparticles (Ag-NPs) were synthesized by autoclaving technique using, different concentrations of Ag salt (AgNO3) solution (1, 5, 10, and 25 mM). Their presence was confirmed by a surface plasmon resonance band at ∼435 nm using UV-Vis absorption spectra...
June 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28530191/green-synthesis-of-silver-nanoparticles-using-bovine-skin-gelatin-and-its-antibacterial-effect-on-clinical-bacterial-isolates
#15
Hosam I Salaheldin, Meshal H K Almalki, Gamal E H Osman
Nanoparticles are being increasingly used in day-to-day life. Therefore, concerns have been raised regarding their interactions with the surrounding environment. This study focused on a simple green method for synthesizing silver nanoparticles (Ag-NPs) in an autoclave at 15 psi (103 kPa) and 121°C. An aqueous solution of AgNO3 as a precursor of Ag-NPs and gelatin (type B) reducing and/or stabilizing (capping) agent were used. The effect of various AgNO3 concentrations of certain gelatin concentration and various gelatin concentrations at constant AgNO3 concentration, and autoclaving time, was studied...
June 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28530093/iron-oxide-nanoparticle-powered-micro-optical-coherence-tomography-for-in-situ-imaging-the-penetration-and-swelling-of-polymeric-microneedles-in-the-skin
#16
Razina Z Seeni, Xiaojun Yu, Hao Chang, Peng Chen, Linbo Liu, Chenjie Xu
In recent years, polymeric microneedles (MNs) have attracted keen interests among researchers because of their applicability in transdermal drug delivery and interstitial skin fluid (ISF) extraction. When designing and characterizing such devices, it is critical to monitor their real-time in vitro and in vivo performances to optimize the desired effects, yet most of the existing methods are incapable of such functions. To address this unmet need, we develop a real-time noninvasive imaging methodology by integrating iron oxide (Fe3O4) nanoparticles into polymeric MNs to enhance image contrast for micro-optical coherence tomography (μOCT) imaging...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28511143/dna-assisted-upconversion-nanoplatform-for-imaging-guided-synergistic-therapy-and-laser-switchable-drug-detoxification
#17
Luoyuan Li, Panlong Hao, Peng Wei, Limin Fu, Xicheng Ai, Jianping Zhang, Jing Zhou
The side effects of chemotherapy bring significant physical and psychological suffering to patients. To solve this urgent medical problem, Yb(3+) and Er(3+) co-doped NaLuF4 upconversion nanoparticles (UCNPs) were constructed for upconversion luminescence (UCL)-labeled diagnosis under 980 nm laser irradiation. The UCNPs were then modified layer by layer with polypyrrole and a special programming DNA segment as photothermal conversion agents and controllable drug carriers, respectively. The nanoplatform was successfully used for imaging-guided synergistic therapy (photothermal therapy and chemotherapy) at a safe power density (300 mW cm(-2)), and DNA-assisted detoxification at lower temperature in cancer cells when the laser off...
May 5, 2017: Biomaterials
https://www.readbyqxmd.com/read/28501992/personalized-medicine-ethical-aspects
#18
G Terry Sharrer
In our time of genome-based personalized medicine, clinical research and clinical medicine are accelerating at a quick pace. Faster and cheaper DNA sequencing and protein profiling, microfluidic devices for capturing blood biomarkers, nanoparticles for precise drug delivery and enhanced imaging, rapid computational analysis of massive data inputs, and other technological wonders coalesce to create a kind of Moore's Law for medicine. Needs are obvious, knowledge grows, capital becomes available, but these factors are not entirely sufficient to make health more achievable...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28484307/understanding-acoustic-cavitation-initiation-by-porous-nanoparticles-toward-nanoscale-agents-for-ultrasound-imaging-and-therapy
#19
Adem Yildirim, Rajarshi Chattaraj, Nicholas T Blum, Andrew P Goodwin
Ultrasound is widely applied in medical diagnosis and therapy due to its safety, high penetration depth, and low cost. In order to improve the contrast of sonographs and efficiency of the ultrasound therapy, echogenic gas bodies or droplets (with diameters from 200 nm to 10 µm) are often used, which are not very stable in the bloodstream and unable to penetrate into target tissues. Recently, it was demonstrated that nanobubbles stabilized by nanoparticles can nucleate ultrasound responsive microbubbles under reduced acoustic pressures, which is very promising for the development of nanoscale (<100 nm) ultrasound agents...
August 23, 2016: Chemistry of Materials: a Publication of the American Chemical Society
https://www.readbyqxmd.com/read/28482615/design-of-poly-mpegma-co-maa-hydrogel-based-mpeg-b-pcl-nanoparticles-for-oral-meloxicam-delivery
#20
Yongli Shi, Zhaomin Liu, Yaxing Yang, Xiaojie Xu, Yan Li, Tong Li
To enhance the therapeutic effects of meloxicam (MLX), we developed an oral MLX-loaded poly(ethylene glycol)-b-poly(ε-caprolactone) nanoparticles@hydrogel (MLX-NPs@hydrogel) preparation. The MLX-NPs were fabricated via a solvent evaporation method, and their morphologies were observed by a JEM-1011 transmission electron microscope (TEM). The poly(mPEGMA-co-MAA) hydrogels were synthesized, and studies on their pH sensibilities were carried out in pH1.2, 6.8, and 7.4 buffers. The final MLX-NPs@hydrogel preparation was obtained by immersing the hydrogels in the MLX-NPs suspensions (pH7...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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