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Nanoparticles and medical imaging

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https://www.readbyqxmd.com/read/27915023/anisotropic-noble-metal-nanoparticles-synthesis-surface-functionalization-and-applications-in-biosensing-bioimaging-drug-delivery-and-theranostics
#1
REVIEW
Gokul Paramasivam, Namitharan Kayambu, Arul Maximus Rabel, Ashok K Sundramoorthy, Anandhakumar Sundaramurthy
Anisotropic nanoparticles have fascinated scientists and engineering communities for over a century because of their unique physical and chemical properties. In recent years, continuous advances in design and fabrication of anisotropic nanoparticles have opened new avenues for application in various areas of biology, chemistry and physics. Anisotropic nanoparticles have the plasmon absorption in the visible as well as near-infrared (NIR) region, which enable them to be used for crucial applications such as biological imaging, medical diagnostics and therapy ("theranostics")...
November 30, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27914328/synthesis-and-stability-of-ir-820-and-fitc-doped-silica-nanoparticles
#2
Atul V Thorat, Tandra Ghoshal, Lan Chen, Justin D Holmes, Michael A Morris
Fluorescent silica nanoparticles (NPs) have potential in biomedical applications as diagnostics and traceable drug delivery agents. In this study, we have synthesized fluorescent dye grafted silica NPs in two step process. First, a stable method to synthesize various sizes of silica NPs ranging from 20 to 52, 95, 210 and 410nm have been successfully demonstrated. Secondly, as-synthesized silica NPs are readily grafted with some fluorescent dyes like IR-820 and fluorescein isothiocyanate (FITC) dyes by simple impregnation method...
November 15, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27876447/coating-microbubbles-with-nanoparticles-for-medical-imaging-and-drug-delivery
#3
Li Min Tay, Chenjie Xu
No abstract text is available yet for this article.
November 23, 2016: Nanomedicine
https://www.readbyqxmd.com/read/27866630/intracellular-synthesis-of-gold-nanoparticles-with-antioxidant-activity-by-probiotic-lactobacillus-kimchicus-dcy51-t-isolated-from-korean-kimchi
#4
Josua Markus, Ramya Mathiyalagan, Yeon-Ju Kim, Ragavendran Abbai, Priyanka Singh, Sungeun Ahn, Zuly Elizabeth Jimenez Perez, Joon Hurh, Deok Chun Yang
A straightforward synthesis of gold nanoparticles (AuNps) is achieved by novel probiotic Lactobacillus kimchicus DCY51(T) isolated from Korean kimchi via an intracellular membrane-bound mechanism. The bioreduction of HAuCl4 into AuNps was verified by ultraviolet-visible spectrophotometry at ∼540nm. AuNps were spherical with varying sizes of 5-30nm. AuNps maintained an average crystallite size of 13nm and demonstrated long-term stability in physiological buffer and biological media. Furthermore, the protective capping layer consisted of amino acid residues and surface-bound proteins rendered them non-toxic to murine macrophage (RAW264...
December 2016: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27866608/noble-metal-oxide-and-chalcogenide-based-nanomaterials-from-scalable-phototrophic-culture-systems
#5
Si Amar Dahoumane, Evan K Wujcik, Clayton Jeffryes
Phototrophic cell or tissue cultures can produce nanostructured noble metals, oxides and chalcogenides at ambient temperatures and pressures in an aqueous environment and without the need for potentially toxic solvents or the generation of dangerous waste products. These "green" synthesized nanobiomaterials can be used to fabricate biosensors and bio-reporting tools, theranostic vehicles, medical imaging agents, as well as tissue engineering scaffolds and biomaterials. While successful at the lab and experimental scales, significant barriers still inhibit the development of higher capacity processes...
December 2016: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27824433/preparation-surface-properties-and-therapeutic-applications-of-gold-nanoparticles-in-biomedicine
#6
Y Panahi, M Mohammadhosseini, K Nejati-Koshki, A J N Abadi, H F Moafi, A Akbarzadeh, M Farshbaf
Gold nanoparticles (AuNPs) due to their unique properties and manifold surface functionalities have been applied in bio-nanotechnology. The application of GNPs in recent medical and biological research is very extensive. Especially it involves applications such as detection and photothermalysis of microorganisms and cancer stem cells, biosensors; optical bio-imaging and observing of cells and these nanostructures also serve as practical platforms for therapeutic agents. In this review we studied all therapeutic applications of gold nanoparticles in biomedicine, synthesis methods, and surface properties...
November 7, 2016: Drug Research
https://www.readbyqxmd.com/read/27818705/fluorescent-nanoprobes-for-sensing-and-imaging-of-metal-ions-recent-advances-and-future-perspectives
#7
JingJing Zhang, FangFang Cheng, JingJing Li, Jun-Jie Zhu, Yi Lu
Recent advances in nanoscale science and technology have generated nanomaterials with unique optical properties. Over the past decade, numerous fluorescent nanoprobes have been developed for highly sensitive and selective sensing and imaging of metal ions, both in vitro and in vivo. In this review, we provide an overview of the recent development of the design and optical properties of the different classes of fluorescent nanoprobes based on noble metal nanomaterials, upconversion nanoparticles, semiconductor quantum dots, and carbon-based nanomaterials...
June 2016: Nano Today
https://www.readbyqxmd.com/read/27816633/cargo-influences-on-the-biodistribution-of-hollow-mesoporous-silica-nanoparticles-as-studied-by-quantitative-19-f-magnetic-resonance-imaging
#8
Alexander Pochert, Ina Vernikouskaya, Felix Pascher, Volker Rasche, Mika Lindén
HYPOTHESIS: Biodistribution is a key issue when it comes to medical applications of nanomaterials. Hollow mesoporous silica nanoparticles (HMSNs) loaded with fluorine compounds can be applied as positive magnetic resonance imaging (MRI) contrast agents (CAs). These CAs exhibit an unusual biodistribution which is influenced by the cargo and which could be linked to their serum protein adsorption behaviour. EXPERIMENTS: HMSNs were post-synthetically loaded with perfluoro-15-crown-5-ether (PFCE)...
February 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27793789/inhibition-of-candida-albicans-biofilm-by-pure-selenium-nanoparticles-synthesized-by-pulsed-laser-ablation-in-liquids
#9
Grégory Guisbiers, Humberto H Lara, Ruben Mendoza-Cruz, Guillermo Naranjo, Brandy A Vincent, Xomalin G Peralta, Kelly L Nash
Selenoproteins play an important role in the human body by accomplishing essential biological functions like oxido-reductions, antioxidant defense, thyroid hormone metabolism and immune response; therefore, the possibility to synthesize selenium nanoparticles free of any contaminants is exciting for future nano-medical applications. This paper reports the first synthesis of selenium nanoparticles by femtosecond pulsed laser ablation in de-ionized water. Those pure nanoparticles have been successfully used to inhibit the formation of Candida albicans biofilms...
October 25, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27778003/time-gated-luminescence-bioimaging-with-new-luminescent-nanocolloids-based-on-mo6i8-c2f5coo-6-2-metal-atom-clusters
#10
Chrystelle Neaime, Maria Amela-Cortes, Fabien Grasset, Yann Molard, Stéphane Cordier, Benjamin Dierre, Michel Mortier, Toshiaki Takei, Kohsei Takahashi, Hajime Haneda, Marc Verelst, Séverine Lechevallier
Bioimaging and cell labeling using red or near infrared phosphors emitting in the "therapeutic window" of biological tissues have recently become some of the most active research fields in modern medical diagnostics. However, because organic and inorganic autofluorophores are omnipresent in nature, very often the background signal from fluorochromes other than targeted probes has to be eliminated. This discrimination could be available using a time-gated luminescence microscopy (TGLM) technique associated with long lifetime phosphorescent nanocomposites...
October 25, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27758713/computational-modelling-of-magnetic-nanoparticle-properties-and-in-vivo-responses
#11
David A Winkler
Nanoparticles are finding many applications in medicine and other field like photonics. Magnetic nanoparticles have additional advantages in medicine over non-magnetic hard nanoparticles, as their magnetic properties make them ideal for hyperthermic applications in therapy and for sensitive diagnostic imaging applications. I review the literature on computational models of the magnetic properties of nanoparticles specifically. Such models have the potential to accelerate the design of magnetic nanoparticles for medical applications...
October 18, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27738007/clinically-approved-nanoparticle-imaging-agents
#12
Avnesh S Thakor, Jesse V Jokerst, Pejman Ghanouni, Jos L Campbell, Erik Mittra, Sanjiv S Gambhir
Nanoparticles are a new class of imaging agent used for both anatomic and molecular imaging. Nanoparticle-based imaging exploits the signal intensity, stability, and biodistribution behavior of submicron-diameter molecular imaging agents. This review focuses on nanoparticles used in human medical imaging, with an emphasis on radionuclide imaging and MRI. Newer nanoparticle platforms are also discussed in relation to theranostic and multimodal uses.
December 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27695038/comparison-of-confocal-and-super-resolution-reflectance-imaging-of-metal-oxide-nanoparticles
#13
Emily J Guggenheim, Abdullah Khan, Jeremy Pike, Lynne Chang, Iseult Lynch, Joshua Z Rappoport
The potential for human exposure to manufactured nanoparticles (NPs) has increased in recent years, in part through the incorporation of engineered particles into a wide range of commercial goods and medical applications. NP are ideal candidates for use as therapeutic and diagnostic tools within biomedicine, however concern exists regarding their efficacy and safety. Thus, developing techniques for the investigation of NP uptake into cells is critically important. Current intracellular NP investigations rely on the use of either Transmission Electron Microscopy (TEM), which provides ultrahigh resolution, but involves cumbersome sample preparation rendering the technique incompatible with live cell imaging, or fluorescent labelling, which suffers from photobleaching, poor bioconjugation and, often, alteration of NP surface properties...
2016: PloS One
https://www.readbyqxmd.com/read/27678178/metal-nanoparticles-as-targeted-carriers-circumventing-the-blood-brain-barrier
#14
A C Sintov, C Velasco-Aguirre, E Gallardo-Toledo, E Araya, M J Kogan
Metal nanoparticles have been proposed as a carrier and a therapeutic agent in biomedical field because of their unique physiochemical properties. Due to these physicochemical properties, they can be used in different fields of biomedicine. In relation to this, plasmonic nanoparticles can be used for detection and photothermal destruction of tumor cells or toxic protein aggregates, and magnetic iron nanoparticles can be used for imaging and for hyperthermia of tumor cells. In addition, both therapy and imaging can be combined in one nanoparticle system, in a process called theranostics...
2016: International Review of Neurobiology
https://www.readbyqxmd.com/read/27668964/a-nanoscale-tool-for-photoacoustic-based-measurements-of-clotting-time-and-therapeutic-drug-monitoring-of-heparin
#15
Junxin Wang, Fang Chen, Santiago J Arconada-Alvarez, James Hartanto, Li-Peng Yap, Ryan Park, Fang Wang, Ivetta Vorobyova, Grant Dagliyan, Peter S Conti, Jesse V Jokerst
Heparin anticoagulation therapy is an indispensable feature of clinical care yet has a narrow therapeutic window and is the second most common intensive care unit (ICU) medication error. The active partial thromboplastin time (aPTT) monitors heparin but suffers from long turnaround times, a variable reference range, limited utility with low molecular weight heparin, and poor correlation to dose. Here, we describe a photoacoustic imaging technique to monitor heparin concentration using methylene blue as a simple and Federal Drug Administration-approved contrast agent...
September 28, 2016: Nano Letters
https://www.readbyqxmd.com/read/27587025/eco-friendly-synthesis-of-silver-nanoparticles-through-economical-methods-and-assessment-of-toxicity-through-oxidative-stress-analysis-in-the-labeo-rohita
#16
Muhammad Saleem Khan, Naureen Aziz Qureshi, Farhat Jabeen, Muhammad Saleem Asghar, Muhammad Shakeel, Muhammad Fakhar-E-Alam
The physicochemical and biological properties of metals change as the particles are reduced to nanoscale. This ability increases the application of nanoparticles in commercial and medical industry. Keeping in view this importance, Silver nanoparticles (Ag-NPs) were synthesized by reduction methods using formaldehyde as reducing agent in the chemical route and lemon extracts in the biological route. The scanning electron microscope (SEM) images of nanoparticles suggested that the particles were either agglomerated or spherical in shape with mean diameter of 16...
September 2, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27585675/magnetite-nanoparticle-interactions-with-insulin-amyloid-fibrils
#17
Yun-Wen Chen, Chiung-Wen Chang, Huey-Shan Hung, Mei-Lang Kung, Bi-Wen Yeh, Shuchen Hsieh
Accumulation of amyloid fibrils is one of the likely key factors leading to the development of Alzheimer's disease and other amyloidosis associated diseases. Magnetic nanoparticles (NPs) have been developed as promising medical materials for many medical applications. In this study, we have explored the effects of Fe3O4 NPs on the fibrillogenesis process of insulin fibrils. When Fe3O4 NPs were co-incubated with insulin, Fe3O4 NPs had no effect on the structural transformation into amyloid-like fibrils but had higher affinity toward insulin fibrils...
October 14, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27523480/ability-of-the-marine-bacterium-pseudomonas-fluorescens-ba3sm1-to-counteract-the-toxicity-of-cdse-nanoparticles
#18
Isabelle Poirier, Lauriane Kuhn, Arnaud Demortière, Boris Mirvaux, Philippe Hammann, Johana Chicher, Christelle Caplat, Marie Pallud, Martine Bertrand
UNLABELLED: In the marine environment, bacteria from estuarine and coastal sediments are among the first targets of nanoparticle pollution; it is therefore relevant to improve the knowledge of interactions between bacteria and nanoparticles. In this work, the response of the marine bacterium Pseudomonas fluorescens BA3SM1 to CdSe nanocrystals (CdSe NPs) of 3nm (NP3) and 8nm (NP8) in diameter was evaluated through microscopic, physiological, biochemical and proteomic approaches. Transmission electron microscopy images showed that NP3 were able to penetrate the bacteria, while NP8 were highly concentrated around the cells, embedded in large exopolysaccharides...
October 4, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27499624/endothelial-glycocalyx-conditions-influence-nanoparticle-uptake-for-passive-targeting
#19
Ming J Cheng, Rajiv Kumar, Srinivas Sridhar, Thomas J Webster, Eno E Ebong
Cardiovascular diseases are facilitated by endothelial cell (EC) dysfunction and coincide with EC glycocalyx coat shedding. These diseases may be prevented by delivering medications to affected vascular regions using circulating nanoparticle (NP) drug carriers. The objective of the present study was to observe how the delivery of 10 nm polyethylene glycol-coated gold NPs (PEG-AuNP) to ECs is impacted by glycocalyx structure on the EC surface. Rat fat pad endothelial cells were chosen for their robust glycocalyx, verified by fluorescent immunolabeling of adsorbed albumin and integrated heparan sulfate (HS) chains...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27462904/surface-assembly-configurations-and-packing-preferences-of-fibrinogen-mediated-by-the-periodicity-and-alignment-control-of-block-copolymer-nanodomains
#20
Tian Xie, Ankit Vora, Patrick J Mulcahey, Sonia E Nanescu, Manpreet Singh, Daniel S Choi, Jeffrey K Huang, Chi-Chun Liu, Daniel P Sanders, Jong-In Hahm
The ability to control the specific adsorption and packing behaviors of biomedically important proteins by effectively guiding their preferred surface adsorption configuration and packing orientation on polymeric surfaces may have utility in many applications such as biomaterials, medical implants, and tissue engineering. Herein, we investigate the distinct adhesion configurations of fibrinogen (Fg) proteins and the different organization behaviors between single Fg molecules that are mediated by the changes in the periodicity and alignment of chemically alternating nanodomains in thin films of polystyrene-block-poly(methyl methacrylate) (PS-b-PMMA) block copolymer (BCP)...
August 23, 2016: ACS Nano
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