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Nanoparticles and medical imaging

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https://www.readbyqxmd.com/read/28102031/dual-nano-sized-contrast-agents-in-pet-mri-a-systematic-review
#1
REVIEW
Afsaneh Lahooti, Saeed Sarkar, Sophie Laurent, Saeed Shanehsazzadeh
Nowadays molecular imaging plays a vital role in achieving a successful targeted and personalized treatment. Hence, the approach of combining two or more medical imaging modalities was developed. The objective of this review is to systematically compare recent dual contrast agents in Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) and in some cases Single photon emission computed tomography (SPECT)/MRI in terms of some their characteristics, such as tumor uptake, and reticuloendothelial system uptake (especially liver) and their relaxivity rates for early detection of primary cancer tumor...
November 2016: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/28097599/biosynthesis-characterization-and-bioactivities-evaluation-of-silver-and-gold-nanoparticles-mediated-by-the-roots-of-chinese-herbal-angelica-pubescens-maxim
#2
Josua Markus, Dandan Wang, Yeon-Ju Kim, Sungeun Ahn, Ramya Mathiyalagan, Chao Wang, Deok Chun Yang
A facile synthesis and biological applications of silver (DH-AgNps) and gold nanoparticles (DH-AuNps) mediated by the aqueous extract of Angelicae Pubescentis Radix (Du Huo) are explored. Du Huo is a medicinal root belonging to Angelica pubescens Maxim which possesses anti-inflammatory, analgesic, and antioxidant properties. The absorption spectra of nanoparticles in varying root extract and metal ion concentration, pH, reaction temperatures, and time were recorded by ultraviolet-visible (UV-Vis) spectroscopy...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28095688/effect-of-gold-nanoparticle-size-and-coating-on-labeling-monocytes-for-ct-tracking
#3
Peter Chhour, Johoon Kim, Barbara Benardo, Alfredo Tovar, Shaameen Mian, Harold I Litt, Victor A Ferrari, David P Cormode
With advances in cell therapies, interest in cell tracking techniques to monitor the migration, localization, and viability of these cells continues to grow. X-ray computed tomography (CT) is a cornerstone of medical imaging but has been limited in cell tracking applications due to its low sensitivity toward contrast media. In this study, we investigate the role of size and surface functionality of gold nanoparticles for monocyte uptake to optimize the labeling of these cells for tracking in CT. We synthesized gold nanoparticles (AuNP) that range from 15 to 150 nm in diameter and examined several capping ligands, generating 44 distinct AuNP formulations...
January 18, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28072576/ultrasonic-computed-tomography-imaging-of-iron-oxide-nanoparticles
#4
Or Perlman, Haim Azhari
Iron oxide nanoparticles (IONPs) are becoming increasingly used and intensively investigated in the field of medical imaging. They are currently FDA approved for magnetic resonance imaging (MRI), and it would be highly desirable to visualize them by ultrasound as well. Previous reports using the conventional ultrasound B-scan (pulse-echo) imaging technique have shown very limited detectability of these particles. The aim of this study is to explore the feasibility of imaging IONPs using the through-transmission ultrasound methodology and demonstrate their detectability using ultrasonic computed tomography (UCT)...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28048898/mo-fg-brc-03-design-and-construction-of-a-dielectiric-wall-accelerator
#5
D Westerly
Experimental research in medical physics has expanded the limits of our knowledge and provided novel imaging and therapy technologies for patients around the world. However, experimental efforts are challenging due to constraints in funding, space, time and other forms of institutional support. In this joint ESTRO-AAPM symposium, four exciting experimental projects from four different countries are highlighted. Each project is focused on a different aspect of radiation therapy. From the USA, we will hear about a new linear accelerator concept for more compact and efficient therapy devices...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048246/mo-fg-brc-04-ionacoustic-imaging-for-particle-range-verification
#6
K Parodi
Experimental research in medical physics has expanded the limits of our knowledge and provided novel imaging and therapy technologies for patients around the world. However, experimental efforts are challenging due to constraints in funding, space, time and other forms of institutional support. In this joint ESTRO-AAPM symposium, four exciting experimental projects from four different countries are highlighted. Each project is focused on a different aspect of radiation therapy. From the USA, we will hear about a new linear accelerator concept for more compact and efficient therapy devices...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047462/mo-fg-brc-00-joint-aapm-estro-symposium-advances-in-experimental-medical-physics
#7
Ross Berbeco, Dan Ionascu
Experimental research in medical physics has expanded the limits of our knowledge and provided novel imaging and therapy technologies for patients around the world. However, experimental efforts are challenging due to constraints in funding, space, time and other forms of institutional support. In this joint ESTRO-AAPM symposium, four exciting experimental projects from four different countries are highlighted. Each project is focused on a different aspect of radiation therapy. From the USA, we will hear about a new linear accelerator concept for more compact and efficient therapy devices...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046835/mo-fg-brc-02-low-z-switching-linear-accelerator-targets-new-options-for-image-guidance-and-dose-enhancement-in-radiotherapy
#8
J Robar
Experimental research in medical physics has expanded the limits of our knowledge and provided novel imaging and therapy technologies for patients around the world. However, experimental efforts are challenging due to constraints in funding, space, time and other forms of institutional support. In this joint ESTRO-AAPM symposium, four exciting experimental projects from four different countries are highlighted. Each project is focused on a different aspect of radiation therapy. From the USA, we will hear about a new linear accelerator concept for more compact and efficient therapy devices...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046808/mo-fg-brc-01-mr-guided-radiation-therapy-with-gadolinium-nanoparticles-from-chalkboard-to-first-clinical-trials
#9
L Sancey
Experimental research in medical physics has expanded the limits of our knowledge and provided novel imaging and therapy technologies for patients around the world. However, experimental efforts are challenging due to constraints in funding, space, time and other forms of institutional support. In this joint ESTRO-AAPM symposium, four exciting experimental projects from four different countries are highlighted. Each project is focused on a different aspect of radiation therapy. From the USA, we will hear about a new linear accelerator concept for more compact and efficient therapy devices...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043119/bioconjugated-nanoparticles-for-biosensing-in-vivo-imaging-and-medical-diagnostics
#10
Brad A Kairdolf, Ximei Qian, Shuming Nie
Bioconjugated nanoparticles are of considerable current interest because materials on the nanometer scale have unique optical, electronic, and magnetic properties with broad applications in biosensing, molecular imaging, and medical diagnostics. In particular, recent advances have led to the development of nanomaterials for a variety of applications, including iron oxide nanocrystals for magnetic resonance imaging (MRI), fluorescent quantum dots (QDs) for multiplexed molecular diagnosis and in vivo imaging, and gold nanoparticles for surface-enhanced Raman scattering...
December 19, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27994465/polyethylenimine-functionalized-silver-nanoparticle-based-co-delivery-of-paclitaxel-to-induce-hepg2-cell-apoptosis
#11
Yinghua Li, Min Guo, Zhengfang Lin, Mingqi Zhao, Misi Xiao, Changbing Wang, Tiantian Xu, Tianfeng Chen, Bing Zhu
Hepatocarcinoma is the third leading cause of cancer-related deaths around the world. Recently, a novel emerging nanosystem as anticancer therapeutic agents with intrinsic therapeutic properties has been widely used in various medical applications. In this study, surface decoration of functionalized silver nanoparticles (AgNPs) by polyethylenimine (PEI) and paclitaxel (PTX) was synthesized. The purpose of this study was to evaluate the effect of Ag@ PEI@PTX on cytotoxic and anticancer mechanism on HepG2 cells...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27993015/cytosolic-transport-of-nanoparticles-through-pressurized-plasma-membranes-for-molecular-delivery-and-amplification-of-intracellular-fluorescence
#12
Yoshihisa Kaizuka, Tomoto Ura, Shaowei Lyu, Ling Chao, Joel Henzie, Hidenobu Nakao
Transporting nanoparticles into live cells is important for drug delivery and other related applications. We found that cells exposed to hypoosmotic pressures can internalize substantial quantities of gold nanoparticles. Importantly, these nanoparticles can circumvent normal intracellular traffic and be transported directly into the cytosol, without the need for surface functionalization. In contrast, nanoparticles endocytosed at physiological osmolality are segregated inside endocytic organelles and are not able to reach the cytosol...
December 20, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27986208/advances-in-prostate-cancer-magnetic-resonance-imaging-and-positron-emission-tomography-computed-tomography-for-staging-and-radiotherapy-treatment-planning
#13
REVIEW
Drew Moghanaki, Baris Turkbey, Neha Vapiwala, Behfar Ehdaie, Steven J Frank, Patrick W McLaughlin, Mukesh Harisinghani
Conventional prostate cancer staging strategies have limited accuracy to define the location, grade, and burden of disease. Evaluations have historically relied upon prostate-specific antigen levels, digital rectal examinations, random systematic biopsies, computed tomography, pelvic lymphadenectomy, or (99m)technetium methylene diphosphonate bone scans. Today, risk-stratification tools incorporate these data in a weighted format to guide management. However, the limitations and potential consequences of their uncertainties are well known...
January 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/27934165/aspirin-based-carbon-dots-a-good-biocompatibility-of-material-applied-for-bioimaging-and-anti-inflammation
#14
Xiaowei Xu, Kai Zhang, Liang Zhao, Chen Li, Wenhuan Bu, Yuqin Shen, Zhongyi Gu, Bei Chang, Changyu Zheng, Chongtao Lin, Hongchen Sun, Bai Yang
The emerging photoluminescent carbon-based nanomaterials are promising in various fields besides cell imaging and carrier transport. Carbon nanomaterials with specific biological functions, however, are rarely investigated. Aspirin is a very common anti-inflammatory medication to relieve aches and pains. In this study, we have tried to create a carbon nanoparticle with aspirin, and we expect that this new carbon nanoparticle will have both anti-inflammatory and fluorescent biomarker functions. Fluorescent aspirin-based carbon dots (FACDs) were synthesized by condensing aspirin and hydrazine through a one-step microwave-assisted method...
December 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27928781/mechanism-of-fluorescence-enhancement-of-biosynthesized-xfe2o4-bifeo3-x-cr-mn-co-or-ni-membranes
#15
Liang Bian, Hai-Long Li, Hai-Liang Dong, Fa-Qin Dong, Mian-Xin Song, Li-Sheng Wang, Wen-Ping Hou, Lei Gao, Xiao-Yan Zhang, Tian-Liang Zhou, Guang-Ai Sun, Xin-Xi Li, Lei Xie
Ferrites-bismuth ferrite is an intriguing option for medical diagnostic imaging device due to its magnetoelectric and enhanced near-infrared fluorescent properties. However, the embedded XFO nanoparticles are randomly located on the BFO membranes, making implementation in devices difficult. To overcome this, we present a facile bio-approach to produce XFe2O4-BiFeO3 (XFO-BFO) (X = Cr, Mn, Co, or Ni) membranes using Shewanella oneidensis MR-1. The perovskite BFO enhances the fluorescence intensity (at 660 and 832 nm) and surface potential difference (-469 ~ 385 meV and -80 ~ 525 meV) of the embedded spinel XFO...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27915023/anisotropic-noble-metal-nanoparticles-synthesis-surface-functionalization-and-applications-in-biosensing-bioimaging-drug-delivery-and-theranostics
#16
REVIEW
Gokul Paramasivam, Namitharan Kayambu, Arul Maximus Rabel, Ashok K Sundramoorthy, Anandhakumar Sundaramurthy
: Anisotropic nanoparticles have fascinated scientists and engineering communities for over a century because of their unique physical and chemical properties. In recent years, continuous advances in design and fabrication of anisotropic nanoparticles have opened new avenues for application in various areas of biology, chemistry and physics. Anisotropic nanoparticles have the plasmon absorption in the visible as well as near-infrared (NIR) region, which enables them to be used for crucial applications such as biological imaging, medical diagnostics and therapy ("theranostics")...
November 30, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27914328/synthesis-and-stability-of-ir-820-and-fitc-doped-silica-nanoparticles
#17
Atul V Thorat, Tandra Ghoshal, Lan Chen, Justin D Holmes, Michael A Morris
Fluorescent silica nanoparticles (NPs) have potential in biomedical applications as diagnostics and traceable drug delivery agents. In this study, we have synthesized fluorescent dye grafted silica NPs in two step process. First, a stable method to synthesize various sizes of silica NPs ranging from 20 to 52, 95, 210 and 410nm have been successfully demonstrated. Secondly, as-synthesized silica NPs are readily grafted with some fluorescent dyes like IR-820 and fluorescein isothiocyanate (FITC) dyes by simple impregnation method...
November 15, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27876447/coating-microbubbles-with-nanoparticles-for-medical-imaging-and-drug-delivery
#18
Li Min Tay, Chenjie Xu
No abstract text is available yet for this article.
January 2017: Nanomedicine
https://www.readbyqxmd.com/read/27866630/intracellular-synthesis-of-gold-nanoparticles-with-antioxidant-activity-by-probiotic-lactobacillus-kimchicus-dcy51-t-isolated-from-korean-kimchi
#19
Josua Markus, Ramya Mathiyalagan, Yeon-Ju Kim, Ragavendran Abbai, Priyanka Singh, Sungeun Ahn, Zuly Elizabeth Jimenez Perez, Joon Hurh, Deok Chun Yang
A straightforward synthesis of gold nanoparticles (AuNps) is achieved by novel probiotic Lactobacillus kimchicus DCY51(T) isolated from Korean kimchi via an intracellular membrane-bound mechanism. The bioreduction of HAuCl4 into AuNps was verified by ultraviolet-visible spectrophotometry at ∼540nm. AuNps were spherical with varying sizes of 5-30nm. AuNps maintained an average crystallite size of 13nm and demonstrated long-term stability in physiological buffer and biological media. Furthermore, the protective capping layer consisted of amino acid residues and surface-bound proteins rendered them non-toxic to murine macrophage (RAW264...
December 2016: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27866608/noble-metal-oxide-and-chalcogenide-based-nanomaterials-from-scalable-phototrophic-culture-systems
#20
Si Amar Dahoumane, Evan K Wujcik, Clayton Jeffryes
Phototrophic cell or tissue cultures can produce nanostructured noble metals, oxides and chalcogenides at ambient temperatures and pressures in an aqueous environment and without the need for potentially toxic solvents or the generation of dangerous waste products. These "green" synthesized nanobiomaterials can be used to fabricate biosensors and bio-reporting tools, theranostic vehicles, medical imaging agents, as well as tissue engineering scaffolds and biomaterials. While successful at the lab and experimental scales, significant barriers still inhibit the development of higher capacity processes...
December 2016: Enzyme and Microbial Technology
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