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synovitis,ultrasound

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https://www.readbyqxmd.com/read/29712616/what-is-the-added-value-of-ultrasound-joint-examination-for-monitoring-synovitis-in-rheumatoid-arthritis-and-can-it-be-used-to-guide-treatment-decisions-a-systematic-review-and-cost-effectiveness-analysis
#1
Emma Simpson, Emma Hock, Matt Stevenson, Ruth Wong, Naila Dracup, Allan Wailoo, Philip Conaghan, Cristina Estrach, Christopher Edwards, Richard Wakefield
BACKGROUND: Synovitis (inflamed joint synovial lining) in rheumatoid arthritis (RA) can be assessed by clinical examination (CE) or ultrasound (US). OBJECTIVE: To investigate the added value of US, compared with CE alone, in RA synovitis in terms of clinical effectiveness and cost-effectiveness. DATA SOURCES: Electronic databases including MEDLINE, EMBASE and the Cochrane databases were searched from inception to October 2015. REVIEW METHODS: A systematic review sought RA studies that compared additional US with CE...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29709499/in-thumb-base-osteoarthritis-structural-damage-is-more-strongly-associated-with-pain-than-synovitis
#2
Féline P B Kroon, Sjoerd van Beest, Selime Ermurat, Marion C Kortekaas, Johan L Bloem, Monique Reijnierse, Frits R Rosendaal, Margreet Kloppenburg
OBJECTIVE: Osteoarthritis in thumb base joints (first carpometacarpal (CMC-1), scaphotrapeziotrapezoid (STT)) is prevalent and disabling, yet focussed studies are scarce. Our aim was to investigate associations between ultrasonographic and magnetic resonance imaging (MRI) inflammatory features, radiographic osteophytes, and thumb base pain in hand osteoarthritis patients. DESIGN: Cross-sectional analyses were performed in cohorts with MRI (n=202) and ultrasound measurements (n=87)...
April 27, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29703511/validation-of-musculoskeletal-ultrasound-in-the-assessment-of-experimental-gout-synovitis
#3
Esperanza Naredo, Juan Pablo Medina, Sandra Pérez-Baos, Aranzazu Mediero, Gabriel Herrero-Beaumont, Raquel Largo
The objective of this study was to validate musculoskeletal ultrasound (US) in a rabbit model of acute gout. Acute gout was induced by intra-articular injection of monosodium urate (MSU) crystals in 10 rabbits; the 3 controls received vehicle. Rabbit knees were assessed by B-mode and power Doppler (PD) US 24 and 72 h after injections. After 72 h, all rabbits were euthanized. US discriminated between the MSU-injected and control groups with respect to the different inflammatory findings at both at 24 and 72 h and for MSU crystal-related findings after 24 h of injection...
April 24, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29657139/power-doppler-ultrasound-evaluation-of-peripheral-joint-entheses-tendon-and-bursa-abnormalities-in-psoriatic-patients-a-clinical-study
#4
Yuanjiao Tang, Yujia Yang, Xi Xiang, Liyun Wang, Lingyan Zhang, Li Qiu
OBJECTIVE: To evaluate the prevalence rates of peripheral joint, enthesis, tendon, and bursa abnormalities by power Doppler (PD) ultrasonic examination in patients with psoriatic arthritis (PsA), psoriatic patients without clinical signs of arthritis (non-PsA psoriasis group), and healthy individuals, to detect subclinical PsA. METHODS: A total of 253 healthy volunteers, 242 non-PsA psoriatic patients, and 86 patients with PsA were assessed by 2-dimensional and power Doppler (PD) ultrasound...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29618136/the-role-of-ultrasound-defined-tenosynovitis-and-synovitis-in-the-prediction-of-rheumatoid-arthritis-development
#5
Ilfita Sahbudin, Luke Pickup, Peter Nightingale, Gina Allen, Zaeem Cader, Ruchir Singh, Paola de Pablo, Christopher D Buckley, Karim Raza, Andrew Filer
Objectives: Tenosynovitis (TS) is common in early arthritis. However, the value of US-defined TS in predicting RA development is unclear. We assessed the predictive utility of US-defined TS alongside US-defined synovitis and clinical and serological variables in a prospective cohort of early arthritis patients. Methods: One hundred and seven patients with clinically apparent synovitis of one or more joint and symptom duration ⩽3 months underwent baseline clinical, laboratory and US assessment of 19 bilateral joint sites and 16 bilateral tendon compartments...
April 3, 2018: Rheumatology
https://www.readbyqxmd.com/read/29576939/detection-of-linear-features-including-bone-and-skin-areas-in-ultrasound-images-of-joints
#6
Artur Bąk, Jakub Segen, Kamil Wereszczyński, Pawel Mielnik, Marcin Fojcik, Marek Kulbacki
Identifying the separate parts in ultrasound images such as bone and skin plays a crucial role in the synovitis detection task. This paper presents a detector of bone and skin regions in the form of a classifier which is trained on a set of annotated images. Selected regions have labels: skin or bone or none. Feature vectors used by the classifier are assigned to image pixels as a result of passing the image through the bank of linear and nonlinear filters. The filters include Gaussian blurring filter, its first and second order derivatives, Laplacian as well as positive and negative threshold operations applied to the filtered images...
2018: PeerJ
https://www.readbyqxmd.com/read/29552370/effect-of-adalimumab-on-refractory-arthritis-in-juvenile-idiopathic-inflammatory-myopathy-with-anti-mda5-autoantibody
#7
Takako Miyamae, Takuma Hara, Aki Hanaya, Yumi Tani, Takayuki Kishi, Hisashi Yamanaka
A 10-year-old girl manifested persistent fever, skin rash, leg pain, fatigue, and joint pain. Based on muscle weakness, elevated muscle-derived enzymes, magnetic resonance imaging, and skin biopsy results, the diagnosis was juvenile idiopathic inflammatory myopathies (JIIM). Chest CT was normal; the anti-melanoma differentiation-associated protein-5 (anti-MDA5) autoantibody was positive. Initial manifestations subsided after prednisolone (PSL) and methotrexate treatment. After the PSL dosage was decreased, the patient presented with metacarpophalangeal (MCP) joint pain and swelling in both index fingers, synovial fluid, and signals on power Doppler ultrasound...
2018: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/29510818/ultrasonography-for-diagnosis-monitoring-and-treatment-of-tenosynovitis-in-patients-with-rheumatoid-arthritis
#8
Mads Ammitzbøll Danielsen
Rheumatod arthritis is a chronic systemic autoimmune disease, characterized by inflammation in joints and tendon sheaths, which frequently leads to permanent and serious disability due to joint destruction, but also tendon and ligament ruptures. Clinical management of rheumatoid arthritis has traditionally been supported by biochemical and radiographic findings. However, imaging modalities like ultrasound and magnetic resonance imaging (MRI) have improved the possibility for better management of rheumatoid arthritis patients, due to higher sensitivity and specificity for detecting ongoing inflammation, this thesis is focusing on tenosynovitis as recent studies have shown that inflammation in tendon sheaths, i...
March 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29493853/physiotherapist-inter-rater-reliability-of-the-haemophilia-early-arthropathy-detection-with-ultrasound-protocol
#9
D Stephensen, S Classey, H Harbidge, V Patel, S Taylor, A Wells
INTRODUCTION: Prevention of arthropathy is the major goal of haemophilia treatment, and early detection of the first signs of joint damage is important so that prevention strategies can be initiated to limit physical disability and improve quality of life. AIM: The aim of this study was to determine the inter-rater repeatability of the HEAD-US protocol when performed by haemophilia physiotherapists. METHODS: Sixty-three joints (21 elbows, 21 knees and 21 ankles) were examined in 21 patients (mean age; 29...
March 1, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29490959/design-of-a-phase-iv-randomised-double-blind-placebo-controlled-trial-assessing-the-im-p-act-of-r-esidual-inflammation-detected-via-imaging-t-e-chniques-d-rug-levels-and-patient-characteristics-on-the-outcome-of-dose-taper-i-ng-of-adalimumab-in-c-linical-remission
#10
Paul Emery, Gerd R Burmester, Esperanza Naredo, Yijie Zhou, Maja Hojnik, Philip G Conaghan
INTRODUCTION: The current American College of Rheumatology and European League Against Rheumatism treatment recommendations advise tapering biological disease-modifying antirheumatic drug (bDMARD) therapy in patients with rheumatoid arthritis (RA) who achieve stable clinical remission while receiving bDMARDs. However, not all patients maintain remission or low disease activity after tapering or discontinuation of bDMARDs. The aim of the Im P act of R esidual Inflammation Detected via Imaging T E chniques, D rug Levels and Patient Characteristics on the Outcome of Dose Taper I ng of Adalimumab in C linical Remission Rheumatoid Ar T hritis ( RA ) study, or PREDICTRA, is to generate data on patient and disease characteristics that may predict the clinical course of a fixed dose-tapering regimen with the bDMARD adalimumab...
February 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29478412/nivolumab-induced-remitting-seronegative-symmetrical-synovitis-with-pitting-edema-in-a-patient-with-melanoma-a-case-report
#11
Linh Ngo, Eric Miller, Peter Valen, Elie Gertner
BACKGROUND: Novel immune checkpoint inhibitors have been often utilized for different types of malignancies as salvage therapy with varying success. One obstacle to immune checkpoint inhibitor use is the higher incidence of immune-mediated side effects that can prompt discontinuation of therapy. Remitting seronegative symmetrical synovitis with pitting edema has been described with immune checkpoint inhibitors only once previously. We report a case of a patient who developed remitting seronegative symmetrical synovitis with pitting edema related to immune checkpoint inhibitor therapy and stress that these symptoms can be managed without cessation of immune checkpoint inhibitor therapy...
February 26, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29465582/successfully-treating-hand-primary-tuberculous-synovitis-by-synovectomy-combined-antituberculous-therapy-a-case-report
#12
Tao Wang, Gang Zhao, Yong-Jun Rui, Jing-Yi Mi
RATIONALE: Primary tuberculous infection in hand and wrist is a rare disease. Few articles reported on hand primary tuberculous synovitis. PATIENT CONCERNS: A 68-year-old Chinese male, without history of tuberculosis (TB), had complained of pain and swelling in right palm and little finger for 3 months. Patient came to our hospital on 9th Oct 2016. X-ray just showed soft tissue swelling in little finger. Magnetic resonance imaging (MRI) showed synovitis around flexor tendon of little finger, volar palm, and carpal tunnel...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29457379/levels-of-cytokines-and-micrornas-in-individuals-with-asymptomatic-hyperuricemia-and-ultrasonographic-findings-of-gout-a-bench-to-bedside-approach
#13
Irving O Estevez-Garcia, Selma Gallegos-Nava, Erika Vera-Pérez, Luis H Silveira, Lucio Ventura-Ríos, Gonzalo Vancini, Cristina Hernández-Díaz, Fausto Sánchez-Muñoz, Martha A Ballinas-Verdugo, Marwin Gutierrez, Carlos Pineda, Pedro Rodriguez-Henriquez, Diana Castillo-Martínez, Luis M Amezcua-Guerra
OBJECTIVE: To assess potential associations among serum cytokines and microRNA (miR) levels with ultrasound (US) findings suggestive of urate deposits in chronic asymptomatic hyperuricemia and gout. METHODS: All participants underwent musculoskeletal US and measurements of serum IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IFN-γ, TNF, MCP-1, and ENA-78, as well as miR-146a, miR-155, and miR-223 levels. RESULTS: Thirty individuals with asymptomatic hyperuricemia, 31 normouricemic controls, and 30 gouty patients were included...
February 18, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29437586/baseline-ultrasound-examination-as-possible-predictor-of-relapse-in-patients-affected-by-juvenile-idiopathic-arthritis-jia
#14
Orazio De Lucia, Viviana Ravagnani, Francesca Pregnolato, Arvena Hila, Irene Pontikaki, Maurizio Gattinara, Micol Romano, Valeria Gerloni, Sara Pieropan, Antonella Murgo, Maurizio Rossini, Rolando Cimaz, Pier Luigi Meroni
OBJECTIVES: To define the correlation between joint ultrasonography and clinical examination in patients with juvenile idiopathic arthritis (JIA) and to assess whether synovitis detected by ultrasonography in clinically inactive patients predicts arthritis flares. METHODS: 88 consecutive patients with JIA-46 (52%) with persistent oligoarthritis, 15 (17%) with extended oligoarthritis, 15 (17%) with rheumatoid factor-negative polyarthritis and 12 (14%) with other forms of JIA, all clinically inactive for a minimum of 3 months-underwent ultrasound (US) assessment of 44 joints...
February 6, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29409140/a-multicenter-retrospective-analysis-evaluating-performance-of-synovial-biopsy-techniques-in-patients-with-inflammatory-arthritis-arthroscopic-versus-ultrasound-guided-versus-blind-needle-biopsy
#15
Frances Humby, Vasco C Romão, Antonio Manzo, Andrew Filer, Serena Bugatti, Elsa Vieira-Sousa, Stephen Kelly, Mihir Wechalekar, Manzoor Ahmed, Vidalba Rocher, Rebecca Hands, Carlomaurizio Montecucco, Joao Fonseca, Costantino Pitzalis
OBJECTIVE: To evaluate whether the choice of synovial biopsy technique (arthroscopy, blind needle [BN] biopsy, ultrasound [US]-guided portal and forceps [P&F], or US-guided needle biopsy [NB]) translates to significant variation in synovial tissue quality and quantity, with the aim of informing recommendations for the choice of synovial sampling technique within clinical trials. METHODS: In total, 159 procedures from 5 academic rheumatology centers were evaluated...
May 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29400369/correlation-between-protein-ykl-40-and-ultrasonographic-findings-in-active-knee-osteoarthritis
#16
Rositsa Karalilova, Maria Kazakova, Anastas Batalov, Victoria Sarafian
The aim of our study was to analyze the level of the glycoprotein YKL-40 in patients with active knee osteoarthritis (OA) and to search possible correlations with local inflammation and ultrasound (US) findings. MATERIAL AND METHODS: A prospective study with fifty consecutive patients with active knee OA (diagnosed based on the American College of Rheumatology criteria for OA with radiographic confirmation) was performed. Concentrations of YKL-40 in serum and synovial fluid were measured by ELISA...
February 4, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29383965/the-value-of-head-us-system-in-detecting-subclinical-abnormalities-in-joints-of-patients-with-hemophilia
#17
Hortensia De la Corte-Rodriguez, E Carlos Rodriguez-Merchan, M Teresa Alvarez-Roman, Mónica Martin-Salces, Carlo Martinoli, Víctor Jimenez-Yuste
BACKGROUND: Prevention of hemarthrosis is the key factor in the adequate management of people with hemophilia (PWH). If hemarthrosis occurs, early diagnosis of joint damage is essential to make personalized treatments. This study is aimed at gaining an understanding of the ability of point-of-care ultrasound (US) using the `Hemophilia Early Arthropathy Detection with Ultrasound´ (HEAD-US) protocol to detect abnormalities in joints without history of hemarthrosis and clinically asymptomatic joints of PWH...
March 2018: Expert Review of Hematology
https://www.readbyqxmd.com/read/29370856/ultrasonography-and-magnetic-resonance-imaging-changes-in-patients-with-polymyalgia-rheumatica-treated-by-tocilizumab
#18
Anaïs Huwart, Florent Garrigues, Sandrine Jousse-Joulin, Thierry Marhadour, Dewi Guellec, Divi Cornec, Maelenn Gouillou, Alain Saraux, Valérie Devauchelle-Pensec
BACKGROUND: This study assessed inflammatory changes using ultrasound (US) and magnetic resonance imaging (MRI) in patients taking tocilizumab for polymyalgia rheumatica (PMR). METHODS: Eighteen patients were included in the prospective open-label TENOR study and received three tocilizumab infusions, without corticosteroids. B-mode and power Doppler US and MRI (T1 and T2-short time inversion recuperation weighted sequences) of the hips and shoulders were performed at weeks 0, 2, and 12...
January 25, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29366644/what-does-power-doppler-signal-indicate-in-rheumatoid-synovitis-a-point-of-view-from-synovial-histopathology
#19
Kuo-Lung Lai, Der-Yuan Chen, Mei-Chin Wen, Yi-Ming Chen, Wei-Ting Hung, Yi-Hsin Chen, Hsin-Hua Chen
To clarify the nature of power Doppler (PD) signals in rheumatoid synovium and to establish the connection between PD signals and active inflammation using synovial histopathology. Ten adult patients (median age 57.0 years, 9 women and one man) with rheumatoid arthritis (RA) were enrolled and received ultrasound (US) examinations. US-guided synovial biopsies using core needle were performed in 7 knees, 2 wrists and one elbow. Each patient had one joint biopsied. In total, 11 synovial specimens were obtained for hematoxylin and eosin staining and histopathologic examinations...
April 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29350637/clinical-utility-of-eco-color-power-doppler-ultrasonography-and-contrast-enhanced-magnetic-resonance-imaging-for-interpretation-and-quantification-of-joint-synovitis-a-review
#20
Marina Carotti, Vittoria Galeazzi, Francesca Catucci, Marcello Zappia, Francesco Arrigoni, Antonio Barile, Andrea Giovagnoni
With the introduction of new biologics such as anti-TNF-alpha antibodies and other therapies in the treatment of inflammatory arthritis, capable of halting joint destruction and functional disability, there are new pressures on diagnostic and prognostic imaging. Early demonstration of pre-erosive inflammatory features and monitoring of the long-term effects of treatment are becoming increasingly important. Early detection of synovitis offers advantages in terms of allowing early instigation of therapy and may allow the identification of those patients displaying more aggressive disease who might benefit from early intervention with expensive DMARD therapy...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
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