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synovitis,ultrasound

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https://www.readbyqxmd.com/read/29132381/patients-with-juvenile-idiopathic-arthritis-in-clinical-remission-with-positive-power-doppler-signal-in-joint-ultrasonography-have-an-increased-rate-of-clinical-flare-a-prospective-study
#1
Vanessa Bugni Miotto E Silva, Sônia de Aguiar Vilela Mitraud, Rita Nely Vilar Furtado, Jamil Natour, Claudio Arnaldo Len, Maria Teresa de Sande E Lemos Ramos Ascensão Terreri
BACKGROUND: Ultrasonography (US) studies carried out on joints of juvenile idiopathic arthritis (JIA) patients in clinical remission demonstrate the presence of subclinical synovitis. The significance of subclinical synovitis and the positive power Doppler (PD) signal on US in JIA in clinical remission is not well understood. The objectives of this study were to assess whether the changes detected by US in patients with JIA in clinical remission can predict disease flare and to evaluate factors associated with flare and joint damage over 30 months of follow-up...
November 13, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29120570/early-referral-improves-long-term-outcomes-in-rheumatoid-arthritis
#2
Jobie Evans, Andra Negoescu
Rheumatoid arthritis (RA) is a common, chronic systemic inflammatory disease of unclear aetiology leading to synovial hypertrophy and joint inflammation. It typically presents with symmetrical polyarthritis of small joints of the hands or feet, but can also involve larger joints, and have associated extra-articular manifestations. Diagnosis is based on duration of symptoms, joint distribution, level of inflammatory markers and autoantibodies i.e. rheumatoid factor(RhF) and anty-cyclic citrullinated peptide (CCP) antibodies...
May 2017: Practitioner
https://www.readbyqxmd.com/read/29101339/a-functional-study-of-human-inflammatory-arthritis-using-photoacoustic-imaging
#3
Janggun Jo, Guan Xu, Meng Cao, April Marquardt, Sheeja Francis, Girish Gandikota, Xueding Wang
By using our dual-modality system enabling simultaneous real-time ultrasound (US) and photoacoustic (PA) imaging of human peripheral joints, we explored the potential contribution of PA imaging modality to rheumatology clinic. By performing PA imaging at a single laser wavelength, the spatially distributed hemoglobin content reflecting the hyperemia in synovial tissue in metacarpophalangeal (MCP) joints of 16 patients were imaged, and compared to the results from 16 healthy controls. In addition, by performing PA imaging at two laser wavelengths, the spatially distributed hemoglobin oxygenation reflecting the hypoxia in inflammatory joints of 10 patients were imaged, and compared to the results from 10 healthy controls...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29089217/-role-of-ultrasonography-in-rheumatoid-arthritis
#4
Saoussen Miladi, Kaouther Ben Abdelghani, Aliaa Fazaa, Ahmed Laatar, Leith Zakraoui
Ultrasound imaging may have an impact in management patients with rheumatoid arthritis. Through technological improvements, ultrasonography, has become an established imaging technique for the diagnosis and the follow up of this inflammatory chronic disease. In fact, ultrasounds, allow follow up during treatment by evaluating synovitis count and assessment of synovial vascularization by Power Doppler. Besides, erosions are found sooner and more frequently by ultrasonography than with conventional radiography...
October 28, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29065925/ultrasound-verified-inflammation-and-structural-damage-in-patients-with-hereditary-haemochromatosis-related-arthropathy
#5
Christian Dejaco, Andreas Stadlmayr, Christina Duftner, Viktoria Trimmel, Rusmir Husic, Elisabeth Krones, Shahin Zandieh, Emma Husar-Memmer, Gernot Zollner, Josef Hermann, Judith Gretler, Angelika Lackner, Anja Ficjan, Christian Datz, Roland Axman, Jochen Zwerina
BACKGROUND: Chronic arthropathy occurs in approximately two thirds of patients with hereditary haemochromatosis (HH). The aim was to study inflammatory and structural lesions in patients with HH with (HH-A) and without arthropathy (HH-WA) using ultrasonography. METHODS: This was a cross-sectional study of 26 patients with HH-A, 24 with HH-WA and 37 with hand osteoarthritis (HOA). Clinical examination was performed in 68 joints, and we retrieved data on hand function, pain and global disease activity (all using a visual analogue scale (VAS)), morning stiffness and ferritin levels...
October 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29041980/comparison-of-the-clinical-effectiveness-of-us-grading-scoring-system-vs-mri-in-the-diagnosis-of-early-rheumatoid-arthritis-ra
#6
Huajun Xu, Yingchun Zhang, Huimei Zhang, Caishan Wang, Pan Mao
BACKGROUND: As an irreversible disease, a treatment delay can negatively affect treatment response in rheumatoid arthritis (RA). Ultrasound and MRI have played an important role in assessing disease progression and response to treatment in RA for many years. The present study was designed to compare the diagnostic efficacy of ultrasound grading and MRI in early RA. METHODS: In this retrospective study, 62 early RA patients within 12 months of symptom onset were included...
October 17, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29032909/subclinical-synovitis-measured-by-ultrasound-in-rheumatoid-arthritis-patients-with-clinical-remission-induced-by-synthetic-and-biological-modifying-disease-drugs
#7
Marcos Cruces, Soham Al Snih, Natalí Serra-Bonett, Juan C Rivas
BACKGROUND: Rheumatoid arthritis (RA) patients with disease in clinical remission might show subclinical synovitis, which can be related to the progress of structural joint damage. OBJECTIVE: To determine and compare the degree of synovial inflammation by ultrasound (US) in patients with RA in clinical remission, treated with DMARD or combination therapy with DMARD and anti-TNF. METHODS: Hospital-based cross-sectional study of 58 patients with RA in sustained remission for at least 6 months by DAS28 <2...
October 9, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29024421/generalized-estimating-equation-model-to-compare-drug-effects-on-synovitis-of-the-dominant-wrist-in-severe-rheumatoid-arthritis-between-tocilizumab-versus-adalimumab-versus-abatacept-using-high-resolution-ultrasound
#8
Ying-Chou Chen, Wen-Chan Chiu, Fu-Mei Su, Jia-Feng Chen
PURPOSE: The use of biological agents has revolutionized the treatment of rheumatoid arthritis (RA). However, details of serial synovial changes in imaging evaluation are unclear. Using power Doppler (PD) ultrasound, this study aimed to evaluate the comparative efficacy of biologicals for patients with refractory RA, with the hope that these findings could aid in clinical decision making. METHODS: Patients with RA who received abatacept, adalimumab or tocilizumab therapy were enrolled...
October 12, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28987543/ankle-evaluation-in-active-rheumatoid-arthritis-by-ultrasound-a-cross-sectional-study
#9
Ahmed M Elsaman, Ehab Saad Mostafa, Ahmed R Radwan
Ankle joint evaluation is underestimated in many clinical and sonographic scores used for evaluation and follow-up of rheumatoid arthritis (RA) patients. Agreement on examination parameters is poor among sonographic scores that include the ankle joint. More effort is needed to detect the value of ankle joint examination in RA and assessment of ultrasonographic signs according to frequency, disease duration and activity. The objective of this study was to use ultrasound (US) to detect ankle involvement in active RA and to compare findings with disease duration, disease activity and assessment of ankle bone erosion...
October 5, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28978340/ultrasound-of-the-hand-is-sufficient-to-detect-subclinical-inflammation-in-rheumatoid-arthritis-remission-a-post-hoc-longitudinal-study
#10
Hilde Berner Hammer, Tore K Kvien, Lene Terslev
BACKGROUND: Ultrasound (US) is a sensitive method for detecting joint/tendon inflammation in patients with rheumatoid arthritis (RA). Subclinical inflammation is often found in patients with RA in composite score remission. The purpose of the present study was to explore whether US of only the hands is sufficient to identify subclinical inflammation in patients with established RA in clinical remission. METHODS: A total of 209 patients with established RA (81% women, mean [SD] age 53...
October 4, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28965693/-ischiopubic-osteochondrosis-revealed-by-an-atypical-acute-transient-synovitis-of-the-hip-a-case-report
#11
S Stormacq, N Gauquier, O Gilliaux
We report here the case of a 3-year-old patient, who presented a left limp and a total refusal of walking, without any traumatism. Clinical examination revealed a significant pain in the left leg with a limit to the limiting mobilization. Acute phase reactants were slightly elevated. Based on the hip ultrasound, acute transient synovitis of the hip was diagnosed. Following persistent complaints, a hip plain radiography was performed, showing a discreet reshuffle at the right ischiopubic branch. The MRI of the hip revealed a discrete T2 high intensity centered on the right ischiopubic synchondrosis (IPS), corresponding to a Van Neck-Odelberg osteochondrosis...
November 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28948984/scoring-ultrasound-synovitis-in-rheumatoid-arthritis-a-eular-omeract-ultrasound-taskforce-part-2-reliability-and-application-to-multiple-joints-of-a-standardised-consensus-based-scoring-system
#12
Lene Terslev, Esperanza Naredo, Philippe Aegerter, Richard J Wakefield, Marina Backhaus, Peter Balint, George A W Bruyn, Annamaria Iagnocco, Sandrine Jousse-Joulin, Wolfgang A Schmidt, Marcin Szkudlarek, Philip G Conaghan, Emilio Filippucci, Maria Antonietta D'Agostino
OBJECTIVES: To test the reliability of new ultrasound (US) definitions and quantification of synovial hypertrophy (SH) and power Doppler (PD) signal, separately and in combination, in a range of joints in patients with rheumatoid arthritis (RA) using the European League Against Rheumatisms-Outcomes Measures in Rheumatology (EULAR-OMERACT) combined score for PD and SH. METHODS: A stepwise approach was used: (1) scoring static images of metacarpophalangeal (MCP) joints in a web-based exercise and subsequently when scanning patients; (2) scoring static images of wrist, proximal interphalangeal joints, knee and metatarsophalangeal joints in a web-based exercise and subsequently when scanning patients using different acquisitions (standardised vs usual practice)...
2017: RMD Open
https://www.readbyqxmd.com/read/28948983/scoring-ultrasound-synovitis-in-rheumatoid-arthritis-a-eular-omeract-ultrasound-taskforce-part-1-definition-and-development-of-a-standardised-consensus-based-scoring-system
#13
Maria-Antonietta D'Agostino, Lene Terslev, Philippe Aegerter, Marina Backhaus, Peter Balint, George A Bruyn, Emilio Filippucci, Walter Grassi, Annamaria Iagnocco, Sandrine Jousse-Joulin, David Kane, Esperanza Naredo, Wolfgang Schmidt, Marcin Szkudlarek, Philip G Conaghan, Richard J Wakefield
OBJECTIVES: To develop a consensus-based ultrasound (US) definition and quantification system for synovitis in rheumatoid arthritis (RA). METHODS: A multistep, iterative approach was used to: (1) evaluate the baseline agreement on defining and scoring synovitis according to the usual practice of different sonographers, using both grey-scale (GS) (synovial hypertrophy (SH) and effusion) and power Doppler (PD), by reading static images and scanning patients with RA and (2) evaluate the influence of both the definition and acquisition technique on reliability followed by a Delphi exercise to obtain consensus definitions for synovitis, elementary components and scoring system...
2017: RMD Open
https://www.readbyqxmd.com/read/28935637/biological-tapering-and-sonographic-flare-in-rheumatoid-arthritis
#14
Chi-Hua Ko, Jia-Feng Chen, Tien-Tsai Cheng, Han-Ming Lai, Ying-Chou Chen
This study aimed to evaluate the risk of ultrasound-detected synovitis after antitumor necrosis factor (TNF) tapering in patients with rheumatoid arthritis. We recruited patients with rheumatoid arthritis who accepted TNF tapering. Gray-scale synovitis and power Doppler score in bilateral wrists at the dorsal radiolunate joint were evaluated. We defined a sum of bilateral wrist scores of ≥2 as sonographic inflammation. Logistical regression analysis was used to adjust for confounding factors. One hundred and twenty-two patients who received a tapered dose of anti-TNF were enrolled, of whom 96 (78%) had ultrasound-detected synovitis and 26 had no inflammation...
September 20, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28915847/absence-of-ultrasound-inflammation-in-patients-presenting-with-arthralgia-rules-out-the-development-of-arthritis
#15
Myrthe van der Ven, M van der Veer-Meerkerk, D F Ten Cate, N Rasappu, M R Kok, D Csakvari, J M W Hazes, A H Gerards, J J Luime
BACKGROUND: To decrease the burden of disease of rheumatoid arthritis (RA), patients at risk for RA need to be identified as early as possible, preferably when no clinically apparent synovitis can be detected. Up to now, it has been fairly difficult to identify those patients with arthralgia who develop inflammatory arthritis (IA), but recent studies using ultrasound (US) suggest that earlier detection is possible. We aimed to identify patients with arthralgia developing IA within 1 year using US to detect subclinical synovitis at first consultation...
September 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28913168/feasibility-of-photoacoustic-ultrasound-imaging-of-synovitis-in-finger-joints-using-a-point-of-care-system
#16
Pim J van den Berg, Khalid Daoudi, Hein J Bernelot Moens, Wiendelt Steenbergen
We evaluate a portable ultrasound and photoacoustic imaging (PAI) system for the feasibility of a point-of-care assessment of clinically evident synovitis. Inflamed and non-inflamed proximal interphalangeal joints of 10 patients were examined and compared with joints from 7 healthy volunteers. PAI scans, ultrasound power Doppler (US-PD), and clinical examination were performed. We quantified the amount of photoacoustic (PA) signal using a region of interest (ROI) drawn over the hypertrophic joint space. PAI response was increased 4 to 10 fold when comparing inflamed with contralateral non-inflamed joints and with joints from healthy volunteers (p < 0...
December 2017: Photoacoustics
https://www.readbyqxmd.com/read/28870177/will-chinese-external-therapy-with-compound-tripterygium-wilfordii-hook-f-gel-safely-control-disease-activity-in-patients-with-rheumatoid-arthritis-design-of-a-double-blinded-randomized-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Quan Jiang, Xiao-Po Tang, Xian-Chun Chen, Hong Xiao, Ping Liu, Juan Jiao
BACKGROUND: Chinese external therapy (CET) is a topical application with mainly Chinese herb medicine therapy with thousands of years of historical implications and is a clinical routine that is commonly used for relieving joint-related symptoms in patients with arthritis in Chinese hospitals. However, there is a paucity of modern medical evidence to support its effectiveness and safety. Thus, we propose to implement a randomized, double-blinded, placebo-controlled clinical trial in patients with rheumatoid arthritis (RA) using, as the experimental intervention, topical application of a hospital-compounded gel preparation of Tripterygium wilfordii Hook F (TwHF)...
September 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28834302/mtx-use-in-japanese-patients-with-rheumatoid-arthritis
#18
Ayako Hirata, Takehisa Ogura, Norihide Hayashi, Sayaka Takenaka, Hideki Ito, Kennosuke Mizushina, Yuki Fujisawa, Naoko Yamashita, Sumie Nakahashi, Munetsugu Imamura, Rie Kujime, Hideto Kameda
We appreciate the letter from Dr. Carlos Antonio Moura and Dr. Carlos Geraldo Moura for their interest in our article [1]. As they noticed, that study was intended to evaluate the concordance of patient-reported joint symptoms, physician-examined arthritic signs, and ultrasound-detected synovitis in rheumatoid arthritis (RA), but not to evaluate the use of MTX. Although we described the median and range of RA duration (months) as 31 and 0-608, we should have clearly stated that 11 of 50 patients enrolled in that study were treatment-naïve...
August 22, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28832684/relationship-between-serum-calprotectin-s100a8-9-and-clinical-laboratory-and-ultrasound-parameters-of-disease-activity-in-rheumatoid-arthritis-a-large-cohort-study
#19
Jana Hurnakova, Hana Hulejova, Jakub Zavada, Petra Hanova, Martin Komarc, Herman Mann, Martin Klein, Olga Sleglova, Marta Olejarova, Sarka Forejtova, Olga Ruzickova, Jiri Vencovsky, Karel Pavelka, Ladislav Senolt
BACKGROUND: Calprotectin may be a sensitive biomarker of rheumatoid arthritis (RA) disease activity. OBJECTIVES: In the current study, we investigated whether calprotectin is a better biomarker than CRP for predicting clinical activity and ultrasound parameters in patients with RA. METHODS: A total of 160 patients with RA underwent clinical (swollen joint count-SJC, tender joint count-TJC, Disease Activity Score-DAS28, Clinical Disease Activity Index-CDAI, and simplified Disease Activity Index-SDAI) and ultrasound (German US7) examination...
2017: PloS One
https://www.readbyqxmd.com/read/28831575/a-simplified-and-validated-ultrasound-scoring-system-to-evaluate-synovitis-of-bilateral-wrists-and-hands-in-patients-with-rheumatoid-arthritis
#20
Xiaoying Sun, Xuerong Deng, Yan Geng, Lanlan Ji, Wenhui Xie, Xiaohui Zhang, Zhuoli Zhang
The objective of this study was to develop and validate an optimal simplified combination of joints for ultrasonographic assessment of synovitis in wrists and hands in patients with rheumatoid arthritis (RA). Twenty-two joints, including bilateral wrists, all proximal interphalangeal (PIP), and metacarpophalangeal (MCP) joints, were evaluated by grey-scale (GS) and power Doppler (PD) ultrasound using semi-quantitative scoring systems in 705 RA patients. Candidate joint sets were then selected by multiple linear regression analysis and the optimal candidate set was eventually validated in 235 RA patients...
August 22, 2017: Clinical Rheumatology
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