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https://www.readbyqxmd.com/read/28734043/enabling-reduction-of-low-grade-inflammation-in-seniors-pilot-study-concept-rationale-and-design
#1
Todd M Manini, Stephen D Anton, Daniel P Beavers, Jane A Cauley, Mark A Espeland, Roger A Fielding, Stephen B Kritchevsky, Christiaan Leeuwenburgh, Kristina H Lewis, Christine Liu, Mary M McDermott, Michael E Miller, Russell P Tracy, Jeremy D Walston, Barbara Radziszewska, Jane Lu, Cindy Stowe, Samuel Wu, Anne B Newman, Walter T Ambrosius, Marco Pahor
OBJECTIVES: To test two interventions to reduce interleukin (IL)-6 levels, an indicator of low-grade chronic inflammation and an independent risk factor for impaired mobility and slow walking speed in older adults. DESIGN: The ENabling Reduction of low-Grade Inflammation in SEniors (ENRGISE) Pilot Study was a multicenter, double-blind, placebo-controlled randomized pilot trial of two interventions to reduce IL-6 levels. SETTING: Five university-based research centers...
July 22, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28733268/carriers-of-an-apolipoprotein-e-epsilon-4-allele-are-more-vulnerable-to-a-dietary-deficiency-in-omega-3-fatty-acids-and-cognitive-decline
#2
REVIEW
Tanya Gwendolyn Nock, Raphaël Chouinard-Watkins, Mélanie Plourde
Carriers of an epsilon 4 allele (E4) of apolipoprotein E (APOE) develop Alzheimer's disease (AD) earlier than carriers of other APOE alleles. The metabolism of plasma docosahexaenoic acid (DHA, 22:6n-3), an omega-3 fatty acid (n-3 FA), taken up by the brain and concentrated in neurons, is disrupted in E4 carriers, resulting in lower levels of brain DHA. Behavioural and cognitive impairments have been observed in animals with lower brain DHA levels, with emphasis on loss of spatial memory and increased anxiety...
July 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28730698/boar-sperm-quality-after-supplementation-of-diets-with-omega-3-polyunsaturated-fatty-acids-extracted-from-microalgae
#3
Y T Andriola, F Moreira, E Anastácio, F A Camelo, A C Silva, A S Varela, S M M Gheller, K L Goularte, C D Corcini, T Lucia
This study evaluated effects of diet supplementation with omega-3 polyunsaturated fatty acids (PUFA) from microalgae on boar sperm quality. Two groups of boars (n = 3 each) were fed during 75 days either a commercial diet (control), or the same diet supplemented with omega-3 PUFA from the heterotrophic microalgae Schizochytrium sp. (120 g/kg). Sixteen ejaculates were collected per boar. Some sperm kinetics parameters were inferior for supplemented than for control boars (p < .05): distance average path; distance in both curved and straight line; velocity average path, velocity in both curved and straight line; and amplitude of lateral head displacement...
July 21, 2017: Andrologia
https://www.readbyqxmd.com/read/28730165/plasma-free-fatty-acids-in-hyperemesis-gravidarum-pregnancy
#4
Mustafa Ulubay, Mustafa Ozturk, Ozlem Ozturk, Ugur Keskin, Ulas Fidan, Erdim Sertoglu, Hakan Aydin, Ali Yilmaz, Mufit Cemal Yenen
We evaluated the free fatty acids differences in plasma between hyperemesis gravidarum(HG) and healthy pregnant in first trimester pregnancy. OBJECTIVE: We aimed to compare the plasma levels of DHA, AA and EPA, between HG patients and healthy pregnant women. DESIGN: Fifty-two pregnants were involved in the study. Twenty-six pregnants of them were HG as study group, and twenty-six pregnants were enrolled as healthy pregnant women at the similar gestational age. The saturated fatty acids C14, C15, C16, C18, C20, C22, and C24; the omega-3 fatty acids eicosapentaenoic acid, (EPA) and docosahexaenoic acid, (DHA); the omega-6 fatty acids linoleic acid, arachidonic acid (AA), and homo-gamma-linolenic acid; and the omega-9 fatty acids oleic acid, erucic acid, and nervonic acid were analysed by gas chromatography...
2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/28723414/omega-3-polyunsaturated-fatty-acids-as-a-treatment-strategy-for-nonalcoholic-fatty-liver-disease
#5
REVIEW
Donald B Jump, Kelli A Lytle, Christopher M Depner, Sasmita Tripathy
Obese and type 2 diabetic (T2DM) patients have a high prevalence of nonalcoholic fatty liver disease (NAFLD). NAFLD is a continuum of chronic liver diseases ranging from benign hepatosteatosis to nonalcoholic steatohepatitis (NASH), cirrhosis and primary hepatocellular cancer (HCC). Because of its strong association with the obesity epidemic, NAFLD is rapidly becoming a major public health concern worldwide. Surprisingly, there are no FDA approved NAFLD therapies; and current therapies focus on the co-morbidities associated with NAFLD, namely, obesity, hyperglycemia, dyslipidemia, and hypertension...
July 16, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28721583/microbial-and-genetically-engineered-oils-as-replacements-for-fish-oil-in-aquaculture-feeds
#6
REVIEW
M Sprague, M B Betancor, D R Tocher
As the global population grows more of our fish and seafood are being farmed. Fish are the main dietary source of the omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, but these cannot be produced in sufficient quantities as are now required for human health. Farmed fish have traditionally been fed a diet consisting of fishmeal and fish oil, rich in n-3 LC-PUFA. However, the increase in global aquaculture production has resulted in these finite and limited marine ingredients being replaced with sustainable alternatives of terrestrial origin that are devoid of n-3 LC-PUFA...
July 18, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28720931/quality-attributes-of-dahi-prepared-from-milk-fortified-with-omega-3-fatty-acids-phytosterols-and-polydetxrose
#7
N Veena, B Surendra Nath, Bandla Srinivas, B V Balasubramanyam
In the present study, dahi prepared using milk fortified with omega-3 fatty acids (flaxseed oil), phytosterols and soluble fibre (polydextrose) through an oil-in-water emulsion was evaluated for the physico-chemical and sensory quality. The levels of fortificants in fortified dahi were also estimated. Fortification process did not affect the degree of fermentation in terms of pH and acidity. Sensory scores of fortified and control dahi did not differ significantly. Fortified dahi had lower viscosity, firmness and consistency, and higher water holding capacity (WHC) compared to control; however, significant differences were not observed in firmness and consistency values...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28719823/supplementation-with-dietary-linseed-oil-during-peri-puberty-stimulates-steroidogenesis-and-testis-development-in-rams
#8
REVIEW
Wanhong Li, Defu Tang, Fadi Li, Huaqin Tian, Xiangpeng Yue, Fei Li, Xiuxiu Weng, Wu Sun, Weimin Wang, Futao Mo
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs), such as α-linolenic acid (ALA), eicosapentaenoic acid, and docosahexaenoic acid, are involved in male reproductive function. In this study, we investigated the effects of linseed oil (LO) as a source of ALA on the steroidogenesis and changes of testicular histology in rams. Sixteen 3-month old rams during peri-puberty were randomly assigned into two groups. Eight rams were assigned as the control group, and the other received LO (4% dry matter of total diet) as the LO treatment group...
July 10, 2017: Theriogenology
https://www.readbyqxmd.com/read/28718800/enriching-diet-with-n-3-pufas-to-help-prevent-cardiovascular-diseases-in-healthy-adults-results-from-clinical-trials
#9
REVIEW
Matteo Manuelli, Lucio Della Guardia, Hellas Cena
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are believed to be important for cardiovascular health. Many investigations have been carried out in an attempt to examine the effect of n-3 PUFAs intake, in the form of supplementation or fortified foods, for the management of cardiovascular disease (CVD) and risk factors for CVD, whereas less is known about the effect on healthy individuals. The present study reviews the available literature in order to examine the relationship between n-3 PUFAs intake, either via supplementation or enriched food, and the prevention of CVD among healthy adults...
July 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28717017/modulation-of-lipid-biosynthesis-by-stress-in-diatoms
#10
REVIEW
Olga Sayanova, Virginie Mimouni, Lionel Ulmann, Annick Morant-Manceau, Virginie Pasquet, Benoît Schoefs, Johnathan A Napier
Diatoms are responsible for up to 40% of the carbon fixation in our oceans. The fixed carbon is moved through carbon metabolism towards the synthesis of organic molecules that are consumed through interlocking foodwebs, and this process is strongly impacted by the abiotic environment. However, it has become evident that diatoms can be used as 'platform' organisms for the production of high valuable bio-products such as lipids, pigments and carbohydrates where stress conditions can be used to direct carbon metabolism towards the commercial production of these compounds...
September 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28716464/modulating-effects-of-omega-3-fatty-acids-and-pioglitazone-combination-on-insulin-resistance-through-toll-like-receptor-4-in-type-2-diabetes-mellitus
#11
Salma M Eraky, Noha Abdel-Rahman, Laila A Eissa
Toll-like receptor 4 (TLR-4) plays important roles in innate immunity. Changes in the reduction-oxidation balance of tissues can lead to a pro-inflammatory state and insulin resistance. An action thought to be mediated by TLRs. Omega-3 fatty acids and Peroxisome Proliferator Activated Receptor gamma (PPAR-γ) agonists as pioglitazone are used for decreasing inflammation. The aim of this study is to investigate the anti-diabetic effects of combining omega -3 fatty acid with pioglitazone on type 2 diabetes, and the modifying effects on TLR-4...
June 17, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28716357/clinical-and-metabolic-response-to-flaxseed-oil-omega-3-fatty-acids-supplementation-in-patients-with-diabetic-foot-ulcer-a-randomized-double-blind-placebo-controlled-trial
#12
Zahra Soleimani, Fatemeh Hashemdokht, Fereshteh Bahmani, Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Zatollah Asemi
BACKGROUND: Data on the effects of flaxseed oil omega-3 fatty acids supplementation on wound healing and metabolic status in subjects with diabetic foot ulcer (DFU) are scarce. OBJECTIVE: This study was conducted to evaluate the effects of flaxseed oil omega-3 fatty acids supplementation on wound healing and metabolic status in subjects with DFU. METHODS: The current randomized, double-blind, placebo-controlled trial was conducted among 60 subjects (aged 40-85years old) with grade 3 DFU...
June 28, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28715242/not-all-masks-are-created-equal-masking-success-in-clinical-trials-of-children-and-adolescents
#13
Lauren Jones, Sarah R Black, L Eugene Arnold, Mary A Fristad
The current study assessed the success of masking omega-3 (Ω3) and psychotherapy in clinical trials of youth with depression or bipolar spectrum disorder. Participants were youth ages 7-14 with DSM-IV-TR diagnosed depressive (n = 72) or bipolar spectrum (n = 23) disorders. Inclusion diagnoses were depressive disorder, cyclothymic disorder, or bipolar disorder not otherwise specified. Exclusion diagnoses included bipolar I or II disorder, chronic medical condition or autism. Youth participated in 2 × 2 randomized controlled trials, in which they received Ω3 or placebo (PBO) and psychoeducational psychotherapy (PEP) or active monitoring (AM)...
July 17, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28713515/effectiveness-of-methylphenidate-and-pufa-for-the-treatment-of-patients-with-adhd-a-double-blinded-randomized-clinical-trial
#14
Mahbobeh Firouzkouhi Moghaddam, Maryam Shamekhi, Tayebeh Rakhshani
BACKGROUND: In some children with ADHD, sub-optimal levels of various nutrients including PUFA especially omega-3 has been observed, and contradictory reports exist on the results of studies conducted on the positive therapeutic effects of PUFA in patients with ADHD. OBJECTIVE: The aim of this study was to investigate the effectiveness of methylphenidate and PUFA on treatment of patients with ADHD in Zahedan, Iran. METHODS: In this clinical trial, 40 children between 6 and 12 years of age with ADHD were investigated in Zahedan in 2014...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28713382/recent-advances-on-nutrition-in-treatment-of-acute-pancreatitis
#15
REVIEW
Li-Long Pan, Jiahong Li, Muhammad Shamoon, Madhav Bhatia, Jia Sun
Acute pancreatitis (AP) is a common abdominal acute inflammatory disorder and the leading cause of hospital admission for gastrointestinal disorders in many countries. Clinical manifestations of AP vary from self-limiting local inflammation to devastating systemic pathological conditions causing significant morbidity and mortality. To date, despite extensive efforts in translating promising experimental therapeutic targets in clinical trials, disease-specific effective remedy remains obscure, and supportive care has still been the primary treatment for this disease...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28712532/influence-of-different-intravenous-lipid-emulsions-on-growth-development-and-laboratory-and-clinical-outcomes-in-hospitalised-paediatric-patients-a-systematic-review
#16
REVIEW
Roy-Rosshan Edward, Jacqueline K Innes, Luise V Marino, Philip C Calder
BACKGROUND & AIMS: Fats in the form of lipid emulsions (LEs) are an integral part of intravenous nutrition. The fatty acid composition of different LEs varies. The exact composition of a LE may influence cell and tissue function and clinical outcome. Currently, it is not clear which LE might be best for paediatric patients. We conducted a systematic review of the effects of different intravenous LEs in hospitalised paediatric patients. METHODS: Randomised controlled trials published in a peer reviewed journal, written in the English language, and comparing two or more different intravenous LEs in hospitalised paediatric patients were included...
July 8, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28710179/omega-3-fatty-acids-fish-oil-supplementation-and-albuminuria-not-a-slam-dunk
#17
EDITORIAL
Sankar D Navaneethan, Salim S Virani
No abstract text is available yet for this article.
July 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28708503/effect-of-dietary-supplementation-of-omega-3-polyunsaturated-fatty-acid-pufa-rich-fish-oil-on-reproductive-performance-of-the-goat-capra-hircus
#18
Ajit Singh Mahla, Ravjibhai K Chaudhari, Atul Kumar Verma, Amit Kumar Singh, Sanjay Kumar Singh, Gyanendra Singh, Mihir Sarkar, Narayan Dutta, Harendra Kumar, Narayanan Krishnaswamy
Dietary supplementation of n-3 PUFA decreases the luteolytic PGF2α and improves the pregnancy rate in the dairy cow. However, its effect in the goat is not known. Accordingly, we studied the effect of supplementation of n-3 PUFA rich Fish oil (FO) on different reproductive events in the goat. Cycling goats (n = 30) were divided into two equal groups and fed an isocaloric and isonitrogenous diet supplemented with either FO (TRT; n = 15) or palm oil (PO) (CON; n = 15) @ 0.6 mL/kg body weight for 72 days during the breeding season...
May 26, 2017: Theriogenology
https://www.readbyqxmd.com/read/28707950/disentangling-gratitude-a-theoretical-and-psychometric-examination-of-the-gratitude-resentment-and-appreciation-test-revised-short-grat-rs
#19
Joseph H Hammer, Rachel E Brenner
This study extended our theoretical and applied understanding of gratitude through a psychometric examination of the most popular multidimensional measure of gratitude, the Gratitude, Resentment, and Appreciation Test-Revised Short form (GRAT-RS). Namely, the dimensionality of the GRAT-RS, the model-based reliability of the GRAT-RS total score and 3 subscale scores, and the incremental evidence of validity for its latent factors were assessed. Dimensionality measures (e.g., explained common variance) and confirmatory factor analysis results with 426 community adults indicated that the GRAT-RS conformed to a multidimensional (bifactor) structure...
July 14, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28707849/malnutrition-after-bariatric-surgery
#20
Nicolas Taton, Anne-Laure Borel, Marine Chobert Bakouline, Jérôme Fauconnier, Catherine Arvieux, Fabian Reche
BACKGROUND: Malnutrition is a rare but severe complication following obesity surgery. Our objective was to analyze these cases of malnutrition and their management at the Grenoble University Hospital. METHODS: Retrospective data between 2006 to 2016 was analyzed from Department of Medical Information, Severe Obesity Outcome Network, and register of the Department of Artificial Nutrition. Data collected concerned age, sex, anthropometric data, surgical procedures and history of obesity surgery, initial surgical follow-up, delay from surgery, nutritional characteristics, nutritional and surgical management, follow up and outcomes...
July 12, 2017: Minerva Chirurgica
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