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Georgios S Chatzopoulos, Miguel Sanchez, Alejandro Cisneros, Larry F Wolff
Objective To assess the prevalence of symptoms of temporomandibular disorder (TMD) and parafunctional habits as well as to investigate their association with age, gender, and number of missing teeth. Methods This retrospective study is based on 4204 randomly selected patients who were examined to determine their symptoms of TMD, such as clicking, difficulty chewing, difficulty opening/closing, as well self-reported joint pain and parafunctional habits. Results Clenching/grinding was reported by 26.5% of the examined population, clicking by 14...
November 16, 2017: Cranio: the Journal of Craniomandibular Practice
Christina Mejersjö, Ove Bertilsson, Karin Bäck
OBJECTIVE: The aims of the study are to assess the reliability of the short clinical examination, and to compare the information gained with a well-known and validated examination, the diagnostic criteria for temporomandibular disorders (DC/TMD). MATERIALS AND METHODS: The study comprises 52 consecutive, newly referred patients at their first visit and examination to an Orofacial Pain and TMD Clinic, 15 years and older, mean age 44 years. The patients first answered three screening questions for reported symptoms...
November 15, 2017: Acta Odontologica Scandinavica
Hiroyuki Kusuhara, Tadayuki Takashima, Hisako Fujii, Tsutomu Takashima, Masaaki Tanaka, Akira Ishii, Shusaku Tazawa, Kazuhiro Takahashi, Kayo Takahashi, Hidekichi Tokai, Tsuneo Yano, Makoto Kataoka, Akihiro Inano, Suguru Yoshida, Takamitsu Hosoya, Yuichi Sugiyama, Shinji Yamashita, Taisuke Hojo, Yasuyoshi Watanabe
The aim of the present study is to investigate the pharmacokinetics of our newly developed aromatase inhibitors (cetrozole and TMD-322) in healthy subjects by a cassette microdose strategy. A cocktail of cetrozole and TMD-322 was administered intravenously or orally (1.98 μg for each drug) to six healthy volunteers in a crossover fashion. Anastrozole (1.98 μg) was also included in the oral cocktail. Total body clearance and bioavailability were 12.1 ± 7.1 mL/min/kg and 34.9 ± 32.3% for cetrozole, and 16...
September 21, 2017: Drug Metabolism and Pharmacokinetics
Hemant Maheshkumar Jivnani, Shuchi Tripathi, Rama Shanker, Balendra Pratap Singh, Kaushal Kishor Agrawal, Rameshwari Singhal
PURPOSE: To determine the prevalence of temporomandibular disorders (TMD) in medical university students and to analyze the relationship of TMD with psychological and functional occlusal parameters. MATERIALS AND METHODS: 200 students (mean age 21.81 ± 1.99) were screened for TMD with the TMD Pain Screener. Clinical examinations identified the participants with TMD. Based on their diagnostic criteria for TMD (DC/TMD) axis I diagnosis, participants were divided into three groups: group 1- non-TMD, group 2- pain related TMD and headaches, and group 3- intra-articular joint disorders...
November 14, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
Shengxue Yang, Minghui Wu, Bin Wang, Li-Dong Zhao, Li Huang, Chengbao Jiang, Su-Huai Wei
Van der Waals heterojunctions formed by stacking various two-dimensional (2D) materials have a series of attractive physical properties, thus offering an ideal platform for versatile electronic and optoelectronic applications. Here, we report few-layer SnSe/MoS2 van der Waals heterojunctions and study their electrical and optoelectronic characteristics. The new heterojunctions present excellent electrical transport characteristics with a distinct rectification effect and a high current on/off ratio (~ 1 × 105)...
November 14, 2017: ACS Applied Materials & Interfaces
Jian Zhou, Puru Jena
Two-dimensional group VI transition-metal dichalcogenides (TMDs) provide a promising platform to encode and manipulate quantum information in the valleytronics. However, the two valleys are energetically degenerate, protected by time-reversal symmetry (TRS). To lift this degeneracy, one needs to break the TRS by either applying an external magnetic field or using a magnetic rare-earth oxide substrate. Here, we predict a different strategy to achieve this goal. We propose that the ferromagnetic group V TMD monolayer, in which the TRS is intrinsically broken, can produce a larger valley and spin splitting...
November 14, 2017: Journal of Physical Chemistry Letters
Shanshan Wang, Qingzhu Liu, Xi Li, Xueyu Zhao, Ling Qiu, Jianguo Lin
Propanidid is an intravenous anesthetic with transient action and rapid recovery features, but it is clinically unacceptable due to its side effects. AZD-3043, an analog of propanidid with the methoxy group substituted by the ethoxy group, has become the focus of recent development efforts. Although propanidid and AZD-3043 are known to act by potentiating the γ-aminobutyric acid type A receptors (GABAARs), their action sites and binding modes in the recognition of target proteins still remain unclear. In this study, molecular docking and ONIOM calculations were performed to explore the possible binding sites and binding modes of propanidid and AZD-3043 with the GABAAR...
November 10, 2017: Journal of Biomolecular Structure & Dynamics
Marika Doepel, Maria Nilner, Tero Vahlberg, Yrsa Le Bell
OBJECTIVE: To study the outcome of oral appliance treatment in myofascial Temporomandibular disorder (TMD) patients with and without comorbid pain using pain site drawings. MATERIAL AND METHODS: This randomized, controlled multicentre study comprised 65 myofascial TMD patients diagnosed according to the Research Diagnostic Criteria for Temporomandibular Disorders. Pain-site drawings were filled in at the baseline examination. The patients were treated with oral appliances...
November 10, 2017: Acta Odontologica Scandinavica
Tetsuo Cai, Masahiro Yonaga, Taisuke Tomita
γ-Secretase is an intramembrane cleaving protease that is responsible for the generation of amyloid-β peptides, which are linked to the pathogenesis of Alzheimer disease. Recently, γ-secretase modulators (GSMs) have been shown to specifically decrease production of the aggregation-prone and toxic longer Aβ species, and concomitantly increase the levels of shorter Aβ. We previously found that phenylimidazole-type GSMs bind to presenilin 1 (PS1), the catalytic subunit of the γ-secretase, and allosterically modulate γ-secretase activity...
November 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Gregory B Cole, Sean E Reichheld, Simon Sharpe
The Vpu protein of HIV-1 functions to downregulate cell surface localization of host proteins involved in the innate immune response to viral infection. For several target proteins, including the NTB-A and PVR receptors and the host restriction factor tetherin, this antagonism is carried out via direct interactions between the transmembrane domains (TMDs) of Vpu and the target. The Vpu TMD also modulates homooligomerization of this protein, and the tetherin TMD forms homodimers. The mechanism through which a single transmembrane helix is able to recognize and interact with a wide range of select targets that do not share known interaction motifs is poorly understood...
November 7, 2017: Biophysical Journal
Emine Akbas, Zerrin Cebi, Erol Cansiz, Sabri Cemil Isler, Sırmahan Cakarer
Purpose: The purpose of this study was to evaluate the efficacy of tranexamic acid (TXA) in reducing blood loss during surgically assisted rapid palatal expansion (SARPE) procedure. Subjects and Methods: A total of 34 patients (12 male, 22 female) who had been treated surgically under general anesthesia with SARPE including pterygoid disjunction for transverse maxillary deficiency (TMD) were included in this study. The study group (n=17) received intravenous (IV) TXA 10 mg/kg as a preoperative bolus; the control group (n=17) received normal saline solution...
2017: J Istanb Univ Fac Dent
José López-Cedrún, Urbano Santana-Mora, María Pombo, Amaya Pérez Del Palomar, Víctor Alonso De la Peña, María Jesús Mora, Urbano Santana
This study assessed 24 adult patients, suffering from severe chronic unilateral pain diagnosed as temporomandibular joint (TMJ) disorder (TMD). The full dentate patients had normal occlusion and had never received an occlusal therapy, i.e., were with natural dental evolution/maturation. The following functional and dynamic factors were assessed: (1) chewing function; (2) TMJ remodeling or the condylar path (CP); and (3) lateral jaw motion or lateral guidance (LG). CPs were assessed using conventional axiography, and LG was assessed by K7 jaw tracking...
November 7, 2017: Scientific Data
Teuta Bicaj, Kujtim Shala, Teuta Pustina Krasniqi, Enis Ahmedi, Linda Dula, Zana Lila-Krasniqi
BACKGROUND: Early diagnosis of temporomandibular disorders (TMD) is important for prevention of greater damages of the parts of the oro-facial system. There are early symptoms that can be used as predictors of TMD. AIM: The study aimed to assess the frequency of the symptoms of TMD among dental students. METHODS: Total number of 166 respondents, all undergraduate dental students, (84 female, 82 male), mean age 22, participated in this study...
October 15, 2017: Open Access Macedonian Journal of Medical Sciences
Kay Chung, Tabitha Richards, Romain Nicot, Alexandre R Vieira, Christiane V Cruz, Gwénaël Raoul, Joel Ferri, James J Sciote
INTRODUCTION: We investigated whether ACTN3, ENPP1, ESR1, PITX1, and PITX2 genes which contribute to sagittal and vertical malocclusions also contribute to facial asymmetries and temporomandibular disorders (TMD) before and after orthodontic and orthognathic surgery treatment. METHODS: One hundred seventy-four patients with a dentofacial deformity were diagnosed as symmetric or subdivided into 4 asymmetric groups according to posteroanterior cephalometric measurements...
November 2017: American Journal of Orthodontics and Dentofacial Orthopedics
Gary M Heir
No abstract text is available yet for this article.
November 2017: Cranio: the Journal of Craniomandibular Practice
Masoud S Loeian, Dominika A Ziolkowska, Farhad Khosravi, Jacek B Jasinski, Balaji Panchapakesan
The ability to convert electrical energy into mechanical motion is of significant interest in many energy conversion technologies. Here, we demonstrate the first liquid phase exfoliated WS2-Nafion nanocomposite based electro-mechanical actuators. Highly exfoliated layers of WS2 mixed with Nafion solution, solution cast and doped with Li(+) was studied as electromechanical actuators. Resonant Raman spectroscopy, X-ray photo-electron-spectroscopy, differential scanning calorimetry, dynamic mechanical analysis, and AC impedance spectroscopy were used to study the structure, photoluminescence, water uptake, mechanical and electromechanical actuation properties of the exfoliated nanocomposites...
November 6, 2017: Scientific Reports
Xiao-Wei Huang, Jing-Jing Wei, Tong Liu, Xue-Liang Zhang, Shu-Meng Bai, Huang-Hao Yang
Two-dimensional transition metal dichalcogenides (TMDs) have attracted rapidly increasing attention due to their fascinating properties and potential applications. However, scalable and cost-effective methods to produce thin-layer TMD nanosheets and their functional composites with environmental benignity are still limited. Herein, we develop a facile and environmentally friendly method for the scalable production of thin-layer TMD nanosheets in an aqueous medium by using silk fibroin, a natural and abundant biopolymer, as the exfoliating agent...
November 16, 2017: Nanoscale
Joseph H Lorent, Blanca Diaz-Rohrer, Xubo Lin, Kevin Spring, Alemayehu A Gorfe, Kandice R Levental, Ilya Levental
Eukaryotic plasma membranes are compartmentalized into functional lateral domains, including lipid-driven membrane rafts. Rafts are involved in most plasma membrane functions by selective recruitment and retention of specific proteins. However, the structural determinants of transmembrane protein partitioning to raft domains are not fully understood. Hypothesizing that protein transmembrane domains (TMDs) determine raft association, here we directly quantify raft affinity for dozens of TMDs. We identify three physical features that independently affect raft partitioning, namely TMD surface area, length, and palmitoylation...
October 31, 2017: Nature Communications
Sandro Legey, Filipe Aquino, Murilo Khede Lamego, Flavia Paes, Antônio Egídio Nardi, Geraldo Maranhão Neto, Gioia Mura, Federica Sancassiani, Nuno Rocha, Eric Murillo-Rodriguez, Sergio Machado
BACKGROUND: Physical activity level (PAL) is known to play an important role in reducing risk factors associated with sedentarism, in addition to improving the mental health and health-related quality of life (HRQL). OBJECTIVE: Investigate the relationship of PAL and their domains with HRQL, mood state (MS) and anxiety. Method: 140 Physical Education students (23.6 ± 3.7 years) were evaluated. The Baecke Habitual Physical Activity and Quality of Life (QOL-36) questionnaires, State-Trait Anxiety Inventories (STAI-S and STAI-T) and Profile of Mood States (POMS) scale were used to investigate PAL, HRQL and mental health indicators...
2017: Clinical Practice and Epidemiology in Mental Health: CP & EMH
C Neboda, R P Anthonappa, N M King
AIM: This study sought to evaluate the tooth mineral density (TMD) for the different lesion types in hypomineralised first permanent molars (FPMs) and compare them to unaffected enamel in clinically sound FPMs. DESIGN: Eighteen FPMs with varying degrees of hypomineralised enamel were grouped into brown, yellow/creamy and white lesion types. Micro-CT was used to determine the TMD for each lesion type, and for unaffected enamel at different locations in the outer, middle, and inner-third of the enamel...
October 28, 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
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