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Emilio Satoshi Hara, Andrea Lusvarghi Witzel, Hajime Minakuchi, Carlos Eduardo de Pitta, Rosane Tronquin Gallo, Masahiro Okada, Takuya Matsumoto, Takuo Kuboki, Marcelo Costa Bolzan
Objective To estimate the effect of a vibratory splint (VibS) in reducing sleep clenching (SC) and TMD pain. Methods Target sample was consecutive 19 TMD patients attending the Orofacial Pain Clinic at FFO-FOUSP. Patients used the VibS or acrylic occlusal splint (OS) as control for 14 days. Outcome variables were SC frequency and pain, assessed by a portable electromyography detector-analyzer (BiteStrip™) and 100 mm VAS, respectively. Statistical analyses were performed with two-way repeated measures ANOVA, and analysis of covariance (ANCOVA)...
July 13, 2018: Cranio: the Journal of Craniomandibular Practice
Aaron J Goodman, Nabeel S Dahod, William A Tisdale
Hybrid quantum dot (QD) / transition metal dichalcogenide (TMD) heterostructures are attractive components of next generation optoelectronic devices, which take advantage of the spectral tunability of QDs and the charge and exciton transport properties of TMDs. Here, we demonstrate tunable electronic coupling between CdSe QDs and monolayer WS2 using variable length alkanethiol ligands on the QD surface. Using femtosecond time-resolved second harmonic generation (SHG) microscopy, we show that electron transfer from photoexcited CdSe QDs to single-layer WS2 occurs on ultrafast (50 fs - 1 ps) timescales...
July 11, 2018: Journal of Physical Chemistry Letters
Fernanda Thomé Brochado, Luciano Henrique de Jesus, Vinicius Coelho Carrard, Angelo Luiz Freddo, Karen Dantur Chaves, Manoela Domingues Martins
The effectiveness of photobiomodulation (PBM) and manual therapy (MT), alone or combined (CT), were evaluated in pain intensity, mandibular movements, psychosocial aspects, and anxiety symptoms of temporomandibular disorder (TMD) patients. Fifty-one TMD patients were randomly assigned to three groups: the PBM group (n = 18), which received PBM with 808 nm, 100 mW, 13.3 J/cm2, and 4 J per point; the MT group (n=16) for 21 minutes each session on masticatory muscles and temporomandibular joint TMJ; and the CT group (n = 17), applied during twelve sessions...
July 10, 2018: Brazilian Oral Research
Pamela Maria Kusdra, Jose Stechman-Neto, Bianca Lopes Cavalcante de Leão, Paulo Francisco Arant Martins, Adriana Bender Moreira de Lacerda, Bianca Simone Zeigelboim
BACKGROUND: Patients with any type of temporomandibular disorder (TMD) may have several symptoms in their temporomandibular joints, masticatory muscles and associated structures, and may have otological symptoms such as tinnitus, ear fullness, ear pain, hearing loss, hyperacusis, and vertigo, which may be due to the anatomical proximity between the temporomandibular joint, muscles innervated by the trigeminal nerve, and ear structures. Objective: This study found a prevalence of ear complaints described in the medical records of patients (n = 485) at the Center for Diagnosis and Treatment of the Temporomandibular Joint and Dental-Facial Functional Alterations at Tuiuti University of Paraná (CDATM/UTP), with TMD evaluated by the Research Diagnostic Criteria/Temporomandibular Disorders (RDC/ TMD)...
June 1, 2018: International Tinnitus Journal
Ji Eun Choi, Jin Myoung Seok, Jungmin Ahn, Yoon Sang Ji, Kyung Myun Lee, Sung Hwa Hong, Byung-Ok Choi, Il Joon Moon
The aim of this study was to investigate hidden hearing loss in patients with Charcot-Marie-Tooth disease type 1 A (CMT1A), a common inherited demyelinating neuropathy. By using pure-tone audiometry, 43 patients with CMT1A and 60 healthy controls with normal sound detection abilities were enrolled. Speech perception in quiet and noisy backgrounds, spectral ripple discrimination (SRD), and temporal modulation detection (TMD) were measured. Although CMT1A patients and healthy controls had similar pure-tone thresholds and speech perception scores in a quiet background, CMT1A patients had significantly (p < 0...
July 9, 2018: Scientific Reports
Christian Ziegeler, Kathrin Wasiljeff, Arne May
Patients with non-dental orofacial pain syndromes will often primarily consult general dentists and other dental specialists. Early and correct diagnosis and therapy is crucial to prevent chronification. We assessed the experience of dentists (general dentists and dental specialists) (n=533) and knowledge level of dental students (n=130) on the diagnosis and treatment of non-dental orofacial pain. We used an anonymized survey containing 14 items with the 4 main themes (i) prescription patterns, (ii) treatment strategies in non-dental orofacial pain, (iii) interdisciplinary cooperation and (iiii) self-assessment of knowledge as well as post-graduate education...
July 5, 2018: European Journal of Pain: EJP
Wook Han, Soon-Chan Kwon, Yong-Jin Lee, Chan Park, Eun-Chul Jang
Background: The aim of this study was to investigate the association between work-related factors and temporomandibular disorders (TMD) among female full-time employees using representative data from a national population-based survey. Methods: Data from the Fourth Korea National Health and Nutrition Examination Survey IV (2007-2009) were used to analyze 1,612 women. Complex samples logistic regression was applied for adjusting for general characteristics and work-related factors to examine the association between work-related factors and TMD...
2018: Annals of Occupational and Environmental Medicine
Mohammad Al-Harthy, Thomas List, Richard Ohrbach, Ambra Michelotti
OBJECTIVES: Women with temporomandibular disorders (TMD) pain from three cultures were assessed for type of treatment received and core illness beliefs. METHODS: In a clinical setting 122 women patients with chronic TMD pain (39 Saudis, 41 Swedes, and 42 Italians) were evaluated for patient characteristics, type of practitioner, type of treatment received and beliefs about TMD prior to consultation in TMD specialist centers. Measures included a survey of treatments received and a beliefs scale regarding contributing, aggravating, and treatment-relevant factors related to the pain...
July 3, 2018: Journal of Oral Rehabilitation
Michael C Lucking, Kory Beach, Humberto Terrones
First principles methods are used to explicitly calculate the nonlinear susceptibility (χ(2) (2ω, ω, ω)) representing the second harmonic generation (SHG) of two dimensional semiconducting materials, namely transition metal dichalcogenides (TMDs) and Boron Nitride (BN). It is found that alloying TMDs improves their second harmonic response, with MoTeS alloys exhibiting the highest of all hexagonal alloys at low photon energies. Moreover, careful examination of the relationship between the concentration of Se in Mox Sey Sz alloys shows that the SHG intensity can be tuned by modifying the stoichiometry...
July 4, 2018: Scientific Reports
Louis R Hollingsworth, Justin A Lemkul, David R Bevan, Anne M Brown
The gp41 transmembrane domain (TMD) of the envelope glycoprotein of the human immunodeficiency virus modulates the conformation of the viral envelope spike, the only druggable target on the surface of the virion. Targeting the envelope glycoprotein with small-molecule and antibody therapies requires an understanding of gp41 TMD dynamics, which is often challenging given the difficulties in describing native membrane properties. Here, atomistic molecular dynamics simulations of a trimeric, prefusion gp41 TMD in a model, asymmetric viral membrane that mimics the native viral envelope were performed...
July 3, 2018: Biophysical Journal
Fernanda Mara de Paiva Bertoli, Carolina Dea Bruzamolin, Graciely Osternack de Almeida Kranz, Estela Maris Losso, Joao Armando Brancher, Juliana Feltrin de Souza
Temporomandibular Disorders (TMD) is a multifactorial condition, which could be associated to occlusal and psychological factors, such as anxiety OBJECTIVE: Investigate if anxiety and malocclusion are associated with the prevalence of TMD in adolescents METHODS: To ensure a population-based representative sample, 934 adolescents aged 10-14 years old from Curitiba-PR, Brazil were randomly selected and examined according to Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and malocclusion by a single calibrated examiner (Kappa>0,80)...
July 4, 2018: Journal of Oral Rehabilitation
Giancarlo De La Torre Canales, Mariana Barbosa Câmara-Souza, Victor Ricardo Manuel Muñoz Lora, Luca Guarda-Nardini, Paulo César Rodrigues Conti, Renata Matheus Rodrigues Garcia, Altair Antoninha Del Bel Cury, Daniele Manfredini
Several studies have described high levels of psychosocial disorders in patients with temporomandibular disorders (TMD), but an estimate of their prevalence in populations of TMD patients has never been assessed systematically OBJECTIVE: To conduct a systematic review of the literature on the prevalence of Research Diagnostic Criteria for TMD (RDC/TMD) axis II findings in TMD patients METHODS: Search for articles was carried out by two independent researchers to retrieve papers published after 1992. Inclusion was reserved to observational studies with a minimum sample size of 100 individuals, which used RDC/TMD diagnostic protocol...
July 4, 2018: Journal of Oral Rehabilitation
M Tuijt, A Parsa, M Koutris, W E R Berkhout, J H Koolstra, F Lobbezoo
Patients with hypermobility disorders of the jaw joint experience joint sounds and jerky movements of the jaw. In severe cases, a subluxation or luxation can occur. Clinically, hypermobility disorders should be differentiated from disc displacements. With biomechanical modeling, we previously identified the anterior slope angle of the eminence and the orientation of the jaw closers to potentially contribute to hypermobility disorders. Using cone-beam computed tomography (CBCT), we constructed patient-specific models of the masticatory system to incorporate these aspects...
July 4, 2018: Journal of Oral Rehabilitation
Jessica Lindlau, Malte Selig, Andre Neumann, Léo Colombier, Jonathan Förste, Victor Funk, Michael Förg, Jonghwan Kim, Gunnar Berghäuser, Takashi Taniguchi, Kenji Watanabe, Feng Wang, Ermin Malic, Alexander Högele
Monolayer transition metal dichalcogenides (TMDs) undergo substantial changes in the single-particle band structure and excitonic optical response upon the addition of just one layer. As opposed to the single-layer limit, the bandgap of bilayer (BL) TMD semiconductors is indirect which results in reduced photoluminescence with richly structured spectra that have eluded a detailed understanding to date. Here, we provide a closed interpretation of cryogenic emission from BL WSe2 as a representative material for the wider class of TMD semiconductors...
July 3, 2018: Nature Communications
Alessandro Chiarotto, Carlotta Viti, Alberto Sulli, Maurizio Cutolo, Marco Testa, Daniele Piscitelli
BACKGROUND: Central sensitization (CS) is an important feature in patients with chronic pain. The Central Sensitization Inventory (CSI) was developed with the goal of detecting the patients' symptoms related to CS. OBJECTIVES: This study aimed at cross-culturally adapting the CSI into Italian, and at assessing its structural and construct validity in patients with different chronic pain disorders. DESIGN: Clinimetric study. METHODS: The Italian version of the CSI (CSI-I) was generated following forward and backward translations, expert committee review, and pilot-testing...
June 15, 2018: Musculoskeletal Science & Practice
Alexander Götz, Christina Scharnagl
The mechanism by which familial Alzheimer's disease (FAD) mutations within the transmembrane domain (TMD) of the Amyloid Precursor Protein (APP) affect ε-endoproteolysis is only poorly understood. Thereby, mutations in the cleavage domain reduce ε-efficiency of γ-secretase cleavage and some even shift entry into production lines. Since cleavage occurs within the TMD, a relationship between processing and TMD structure and dynamics seems obvious. Using molecular dynamic simulations, we dissect the dynamic features of wild-type and seven FAD-mutants into local and global components...
2018: PloS One
Michael J Racich
This paper presents an overview of dental disciplines involved in the treatment of orofacial pain, temporomandibular disorders (TMD), and occlusion and provides an evidence-based contemporary update of their interrelationships. English language peer-reviewed articles were identified using PubMed. Key words bruxism, implants, occlusion, orofacial pain, orthodontics, prosthodontics, restorative dentistry, and TMD were used.
June 29, 2018: Journal of Prosthetic Dentistry
Tae Woog Kang, Juhee Han, Sin Lee, In-Jun Hwang, Su-Ji Jeon, Jong-Min Ju, Man-Jin Kim, Jin-Kyoung Yang, Byoengsun Jun, Chi Ho Lee, Sang Uck Lee, Jong-Ho Kim
The ability to control the dimensions and properties of nanomaterials is fundamental to the creation of new functions and improvement of their performances in the applications of interest. Herein, we report a strategy based on glucan multivalent interactions for the simultaneous exfoliation and functionalization of two-dimensional transition metal dichalcogenides (TMDs) in an aqueous solution. The multivalent hydrogen bonding of dextran with bulk TMDs (WS2 , WSe2 , and MoSe2 ) in liquid exfoliation effectively produces TMD monolayers with binding multivalency for pathogenic bacteria...
June 29, 2018: Nature Communications
Marius Flasinski, Kira Scheibke, Martin Zimmermann, Ursula Creutzig, Katarina Reinhardt, Femke Verwer, Valerie de Haas, Vincent H J van der Velden, Christine von Neuhoff, C Michel Zwaan, Dirk Reinhardt, Jan-Henning Klusmann
Approximately 5% to 10% of children with Down syndrome (DS) are diagnosed with transient myeloproliferative disorder (TMD). Approximately 20% of these patients die within 6 months (early death), and another 20% to 30% progress to myeloid leukemia (ML-DS) within their first 4 years of life. The aim of the multicenter, nonrandomized, historically controlled TMD Prevention 2007 trial was to evaluate the impact of low-dose cytarabine treatment on survival and prevention of ML-DS in patients with TMD. Patients received cytarabine (1...
July 10, 2018: Blood Advances
Donald J Rinchuse, Charles S Greene
INTRODUCTION: The purposes of this study were to determine how many systematic reviews and meta-analyses relating to temporomandibular disorders (TMDs) had been published as of 2017 compared with those published as of 2004 and then to summarize the findings, based on an analysis of the abstracts from those studies. METHODS: A PubMed search was initiated on May 1, 2017. There were 2 separate searches. The first search was for the topic, "temporomandibular disorders...
July 2018: American Journal of Orthodontics and Dentofacial Orthopedics
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