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https://www.readbyqxmd.com/read/28550247/two-novel-mutations-in-the-first-transmembrane-domain-of-presenilin1-cause-young-onset-alzheimer-s-disease
#1
Collin Y Liu, Yu Ohki, Taisuke Tomita, Satoko Osawa, Bruce R Reed, William Jagust, Victoria Van Berlo, Lee-Way Jin, Helena C Chui, Giovanni Coppola, John M Ringman
BACKGROUND: The presenilin-1 protein (PS1) is the catalytic unit of γ-secretase implicated in the production of abnormally long forms of amyloid-β (Aβ), including Aβ42, proteins thought critical in the pathogenesis of Alzheimer's disease (AD). In AD of autosomal dominant inheritance, the majority of pathogenic mutations have been found in the PSEN1 gene within which the location of the mutation can provide clues as to the mechanism of pathogenesis. OBJECTIVE: To describe clinical features of two novel mutations in the transmembrane portion 1 (TMD-1) of PSEN1 as well as biochemical features in one and neuropathological findings in the other...
May 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28549330/impact-of-post-traumatic-stress-disorder-on-oral-health
#2
Ana Cristina de Oliveira Solis, Álvaro Cabral Araújo, Felipe Corchs, Marcio Bernik, Érica Panzani Duran, Cláudio Silva, Francisco Lotufo-Neto
BACKGROUND: The stress experienced as an intense and traumatic event can increase the odds of orofacial pain, affect the biomechanics of masticatory system and compromise the periodontal health. This study was conducted to investigate the impact of post-traumatic stress disorder (PTSD) on oral health. METHODS: A case-control study with a convenience sample was designed. Probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing, and plaque were recorded at 6 sites per tooth...
May 20, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28548860/direct-imaging-of-kinetic-pathways-of-atomic-diffusion-in-monolayer-molybdenum-disulfide
#3
Jinhua Hong, Yuhao Pan, Zhixin Hu, Danhui Lv, Chuanhong Jin, Wei Ji, Jun Yuan, Ze Zhang
Direct observation of atomic migration both on and below surfaces is a long-standing but important challenge in materials science as diffusion is one of the most elementary processes essential to many vital material behaviors. Probing the kinetic pathways, including metastable or even transition states involved down to atomic scale, holds the key to the underlying physical mechanisms. Here, we applied aberration-corrected transmission electron microscopy (TEM) to demon-strate direct atomic-scale imaging and quasi-real-time tracking of diffusion of Mo adatoms and vacancies in monolayer MoS2, an important 2D transition metal dichalcogenide (TMD) system...
May 26, 2017: Nano Letters
https://www.readbyqxmd.com/read/28536523/positive-modulatory-interactions-of-nmda-receptor-glun1-2b-ligand-binding-domains-attenuate-antagonists-activity
#4
Douglas Bledsoe, Ceyhun Tamer, Ivana Mesic, Christian Madry, Bradley G Klein, Bodo Laube, Blaise M Costa
N-methyl D-aspartate receptors (NMDAR) play crucial role in normal brain function and pathogenesis of neurodegenerative and psychiatric disorders. Functional tetra-heteromeric NMDAR contains two obligatory GluN1 subunits and two identical or different non-GluN1 subunits that include six different gene products; four GluN2 (A-D) and two GluN3 (A-B) subunits. The heterogeneity of subunit combination facilities the distinct function of NMDARs. All GluN subunits contain an extracellular N-terminal Domain (NTD) and ligand binding domain (LBD), transmembrane domain (TMD) and an intracellular C-terminal domain (CTD)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28534400/opto-valleytronic-spin-injection-in-monolayer-mos2-few-layer-graphene-hybrid-spin-valves
#5
Yunqiu Kelly Luo, Jinsong Xu, Tiancong Zhu, Guanzhong Wu, Elizabeth Joan McCormick, Wenbo Zhan, Mahesh R Neupane, Roland K Kawakami
Two dimensional (2D) materials provide a unique platform for spintronics and valleytronics due to the ability to combine vastly different functionalities into one vertically-stacked heterostructure, where the strengths of each of the constituent materials can compensate for the weaknesses of the others. Graphene has been demonstrated to be an exceptional material for spin transport at room temperature, however it lacks a coupling of the spin and optical degrees of freedom. In contrast, spin/valley polarization can be efficiently generated in monolayer transition metal dichalcogenides (TMD) such as MoS2 via absorption of circularly-polarized photons, but lateral spin or valley transport has not been realized at room temperature...
May 23, 2017: Nano Letters
https://www.readbyqxmd.com/read/28534305/validation-of-the-social-support-and-pain-questionnaire-spq-in-patients-with-painful-temporomandibular-disorders
#6
Songlin He, Jinhua Wang
BACKGROUND: The present study aimed to validate of Social support and Pain Questionnaire (SPQ) for use in Chinese patients with painful temporomandibular disorders (TMD). METHODS: The Chinese version of SPQ was produced by translation and cross-culturally adaptation of the original English version according to international guidelines. The Chinese version of SPQ was then distributed to a total of 118 patients with painful TMD. Reliability of the SPQ was evaluating using internal consistency and test-retest methods and validity of the SPQ was determined by construct validity and convergent validity...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28530201/ultrafast-growth-of-large-area-monolayer-mos2-film-via-gold-foil-assistant-cvd-for-high-sensitive-photodetector
#7
Changbin Nie, Leyong Yu, Xingzhan Wei, Jun Shun, Wenqiang Lu, Weimin Chen, Shuanglong Feng, Haofei Shi
Two-dimensional molybdenum disulfide (MoS2) is a promising material for ultrasensitive photodetector owing to its tunable band gap and high absorption coefficient. However, controlled synthesis of high quality, large area monolayer molybdenum disulfide (MoS2) is still a challenge in practical application. In this work, we report a gold foil assistant chemical vapor deposition (CVD) method of large size (>400 μm) single crystal MoS2 film on silicon dioxide (SiO2) substrate. The influence of Au foil in enlarging the size of single crystal MoS2 were investigated systemically using thermal simulation in Ansys workbench 16...
May 22, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28521968/localized-myofascial-pain-responds-better-than-referring-myofascial-pain-to-botulinum-toxin-injections
#8
W A Abboud, S Hassin-Baer, M Joachim, N Givol, R Yahalom
Myofascial pain of the muscles of mastication is a common temporomandibular disorder. Patients unresponsive to conservative treatment modalities pose a therapeutic challenge to the treating clinician. The efficacy of intramuscular botulinum toxin injections for recalcitrant cases is still not well established due to mixed results from clinical trials. The Diagnostic Criteria of Temporomandibular Disorders (DC/TMD) classified chronic muscle pain broadly into a localized pattern (when pain is localized to the site of palpation or the muscle palpated) and a referring pattern (when the pain spreads beyond the boundary of the muscle being palpated)...
May 15, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28513742/structural-stability-and-intriguing-electronic-properties-of-two-dimensional-transition-metal-dichalcogenide-alloys
#9
Xiao Yuan, Mingye Yang, Lu Wang, Youyong Li
Based on the first-principles calculations, we systematically studied the structures and electronic properties of two-dimensional (2D) transition metal dichalcogenide (TMD) alloys with half-to-half mixing of S and Se. Using the chemical potentials of S and Se, the energetic phase diagrams for both single phases and mixed phases of TMD were constructed. A new heterolayer structure (for Sc and Ti) and alternating structure (for Cr, Mn, Fe, Zr, Mo, and W) were proposed for the first time, which were thermodynamically stable for MSSe alloys under the S-poor (relatively low chemical potential of S) and Se-rich (relatively high chemical potential of Se) conditions, and further compared with the disordered structures...
May 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28513703/nonlinear-photoluminescence-in-monolayer-ws2-parabolic-emission-and-excitation-fluence-dependent-recombination-dynamics
#10
Xiaopeng Fan, Weihao Zheng, Hongjun Liu, Xiujuan Zhuang, Peng Fan, Yanfang Gong, Honglai Li, Xueping Wu, Ying Jiang, Xiaoli Zhu, Qinglin Zhang, Hong Zhou, Wei Hu, Xiao Wang, Xiangfeng Duan, Anlian Pan
Recombination dynamics during photoluminescence (PL) in two-dimensional (2D) semiconducting transition metal dichalcogenides (TMDs) are complicated and can be easily affected by the surroundings because of their atomically thin structures. Herein, we studied the excitation power and temperature dependence of the recombination dynamics on the chemical vapor deposition-grown monolayer WS2via a combination of Raman, PL, and time-resolved PL spectroscopies. We found a red shift and parabolic intensity increase in the PL emission of the monolayer WS2 with the increasing excitation power and the decay time constants corresponding to the recombination of trions and excitons from transient PL dynamics...
May 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28513578/crystal-structure-of-a-multi-domain-human-smoothened-receptor-in-complex-with-a-super-stabilizing-ligand
#11
Xianjun Zhang, Fei Zhao, Yiran Wu, Jun Yang, Gye Won Han, Suwen Zhao, Andrii Ishchenko, Lintao Ye, Xi Lin, Kang Ding, Venkatasubramanian Dharmarajan, Patrick R Griffin, Cornelius Gati, Garrett Nelson, Mark S Hunter, Michael A Hanson, Vadim Cherezov, Raymond C Stevens, Wenfu Tan, Houchao Tao, Fei Xu
The Smoothened receptor (SMO) belongs to the Class Frizzled of the G protein-coupled receptor (GPCR) superfamily, constituting a key component of the Hedgehog signalling pathway. Here we report the crystal structure of the multi-domain human SMO, bound and stabilized by a designed tool ligand TC114, using an X-ray free-electron laser source at 2.9 Å. The structure reveals a precise arrangement of three distinct domains: a seven-transmembrane helices domain (TMD), a hinge domain (HD) and an intact extracellular cysteine-rich domain (CRD)...
May 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28512128/refined-topology-model-of-the-stt3-sttp3-protein-subunit-of-the-oligosaccharyl-transferase-complex
#12
Patricia Lara, Karin Öjemalm, Johannes Reithinger, Aurora Holgado, You Maojun, Abdessalem Hammed, Daniel Mattle, Hyun Kim, IngMarie Nilsson
The oligosaccharyl transferase (OST) complex, localized in the endoplasmic reticulum (ER) of eukaryotic cells, is responsible for the N-linked glycosylation of numerous protein substrates. The membrane protein STT3 is a highly conserved part of the OST, and likely contains the active site of the complex. However, understanding the catalytic determinants of this system has been challenging, in part because of a discrepancy in the structural topology of the bacterial vs eukaryotic proteins and incomplete information about the mechanism of membrane integration...
May 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28508937/the-prevalence-of-oropharyngeal-dysphagia-in-adults-presenting-with-temporomandibular-disorders-associated-with-rheumatoid-arthritis-a-systematic-review-and-meta-analysis
#13
REVIEW
Órla Gilheaney, Lina Zgaga, Isolde Harpur, Greg Sheaf, Liss Kiefer, Sibylle Béchet, Margaret Walshe
Temporomandibular disorders (TMDs) are the most frequent non-dental orofacial pain disorders and may be associated with rheumatoid arthritis (RA), resulting in oropharyngeal dysphagia (OD). However, clinicians' understanding of involvement with OD caused by RA-related TMDs is limited and the methodological quality of research in this field has been criticised. Therefore, the aim of this study was to systematically review the prevalence of oral preparatory and oral stage signs and symptoms of OD in adults presenting with TMDs associated with RA...
May 16, 2017: Dysphagia
https://www.readbyqxmd.com/read/28507207/role-of-osteocytes-in-mediating-bone-mineralization-during-hyperhomocysteinemia
#14
Viji Vijayan, Sarika Gupta
Hyperhomocysteinemia (HHCY) is a risk factor for osteoporosis but whether HHCY affects bone mineralization or not is still ambiguous. Herein we evaluated whether homocysteine affects tissue mineral density (TMD) of cortical bone and if so the role of osteocytes. CD1 mice administered with homocysteine (5 mg/100 g body weight, i.p.) for 7, 15 and 30 days showed temporal changes in TMD and osteocyte lacunar density in femoral cortices. Short-term administration of homocysteine (day 7) increased osteocyte lacunar density and reduced TMD evidenced by microCT50 while prolonged administration of homocysteine (day 30) reinstated TMD and lacunar density to baseline values...
June 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28502221/reliability-of-mandibular-movement-assessments-depending-on-tmd
#15
Angelika Rauch, Oliver Schierz
OBJECTIVE: This study determines the effect of temporomandibular disorders (TMD) on the reliability of mandibular movement assessments. METHODS: The vertical and horizontal jaw movements, as well as overjet and overbite, were measured twice in 56 consecutively recruited adult subjects with TMD according to the RDC/TMD and 29 controls without TMD diagnosis by experienced dentists utilizing a millimeter ruler. The reliability was determined by intraclass correlation coefficient (ICC)...
May 13, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28498502/real-time-three-dimensional-jaw-tracking-in-temporomandibular-disorders
#16
Danilo Vieira da Cunha, Viviane Veroni Degan, Mário Vedovello Filho, Douglas Peres Bellomo, Marlete Ribeiro Silva, Daniel Antônio Furtado, Adriano Oliveira Andrade, Selma Terezinha Milagre, Adriano Alves Pereira
When a dysfunction occurs in any component of the stomatognathic system, temporomandibular disorders (TMD) may originates. The aim of this study was to compare the deviations, displacement, and the execution speed of mandibular movements among asymptomatic participants and those with TMD. Convenience sampling was used; forty participants diagnosed by clinical evaluation following the Research Diagnostic Criteria for Temporomandibular Disorders were divided into three groups: Arthropathy (GART, 10 participants, 40% men), Myopathy (GMYO, 10 participants, 30% men), and the Control Group (CG, 20 asymptomatic-participants, 25% men)...
May 12, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28495841/lower-body-negative-pressure-decreases-non-invasively-measured-intracranial-pressure-and-internal-jugular-vein-cross-sectional-area-during-head-down-tilt
#17
William Watkins, Alan R Hargens, Shannon Baird, Erika Marie Clary, Brandon R Macias
INTRODUCTION: Long-term space flight induces a near visual acuity change in approximately 50% of astronauts. In some crew members, postflight cerebrospinal fluid (CSF) opening pressures by lumbar puncture are as high as 20.9 mmHg who demonstrated optic disc edema. CSF communicates through the cochlear aqueduct to affect perilymphatic pressure and tympanic membrane motion. We hypothesized that 50 mmHg of lower-body negative pressure (LBNP) during 15° head-down tilt (HDT) would mitigate elevations in internal jugular vein cross-sectional area (IJV CSA) and intracranial pressure (ICP)...
May 11, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28492455/reevaluating-antidepressant-selection-in-patients-with-bruxism-and-temporomandibular-joint-disorder
#18
Royce Rajan, Ye-Ming Sun
Temporomandibular joint disorder (TMD) is a broad pain disorder that refers to several conditions affecting the temporomandibular joint of the jaw and the muscles of mastication. As with most pain disorders, a high prevalence of depression and anxiety is associated with TMD. Research has shown that selective serotonin reuptake inhibitors (SSRIs), the first-line drug therapy for major depressive disorder, may not be suitable for TMD patients because SSRIs can induce teeth-grinding, otherwise known as bruxism...
May 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28487981/inhibition-of-notch1-protects-against-il-1%C3%AE-induced-inflammation-and-cartilage-destruction-in-temporomandibular-chondrocytes
#19
Wanggui Ying, Fang Yuan, Ping He, Ping Ji
Temporomandibular disorder (TMD) is a complex and multifactorial disease, with inflammatory response and cartilage destruction usually associated with its etiology. Notch1 is a type I transmembrane receptor, which is critical in determining the growth, differentiation and survival of various cell types. However, its role and mechanism in interleukin (IL)‑1β‑stimulated temporomandibular chondrocytes remain to be elucidated. In the present study, chondrocytes were isolated from Sprague‑Dawley rats and stimulated by IL‑1β at a concentration of 10 ng/ml, and the expression of Notch1 was inhibited by small interfering RNA...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28487468/epigallocatechin-gallate-has-pleiotropic-effects-on-transmembrane-signaling-by-altering-the-embedding-of-transmembrane-domains
#20
Feng Ye, Chansik Yang, Jiyoon Kim, Christopher J MacNevin, Klaus M Hahn, Dongeun Park, Mark H Ginsberg, Chungho Kim
Epigallocatechin gallate (EGCG) is the principal bioactive ingredient in green tea and has been reported to have many health benefits. EGCG influences multiple signal transduction pathways related to human diseases, including redox, inflammation, cell cycle, and cell adhesion pathways. However, the molecular mechanisms of these varying effects are unclear, limiting further development and utilization of EGCG as a pharmaceutical compound. Here, we examined the effect of EGCG on two representative transmembrane signaling receptors, integrin αIIbβ3 and epidermal growth factor receptor (EGFR)...
May 9, 2017: Journal of Biological Chemistry
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