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https://www.readbyqxmd.com/read/28332854/the-intravoxel-incoherent-motion-mri-of-lateral-pterygoid-muscle-a-quantitative-analysis-in-patients-with-temporomandibular-joint-disorders
#1
Supak Ngamsom, Shin Nakamura, Junichiro Sakamoto, Shinya Kotaki, Akemi Tetsumura, Tohru Kurabayashi
OBJECTIVES: To quantitatively evaluate diffusion and perfusion status of lateral pterygoid muscle (LPM) in patients with temporomandibular joint disorder (TMD) by intravoxel incoherent motion (IVIM) imaging and to correlate with findings on temporomandibular joints (TMJs) by conventional MRI. METHODS: 42 patients with TMD underwent MRI. To assess IVIM parameters, diffusion-weighted imaging was obtained by spin-echo-based single-shot echoplanar imaging. Regions of interest were created on all diffusion-weighted images of the superior belly of the lateral pterygoid (SLP) and inferior belly of the lateral pterygoid (ILP) at b-values 0-500 s mm(-2)...
March 23, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28325759/predicting-the-targeting-of-tail-anchored-proteins-to-subcellular-compartments-in-mammalian-cells
#2
Joseph L Costello, Inês G Castro, Fátima Camões, Tina A Schrader, Doug McNeall, Jing Yang, Evdokia-Anastasia Giannopoulou, Sílvia Gomes, Vivian Pogenberg, Nina A Bonekamp, Daniela Ribeiro, Matthias Wilmanns, Gregory Jedd, Markus Islinger, Michael Schrader
Tail-anchored (TA) proteins contain a single transmembrane domain (TMD) at the C-terminus which anchors them to the membranes of organelles where they mediate critical cellular processes. Accordingly, mutations in genes encoding TA proteins have been identified in a number of severe inherited disorders. Despite the importance of correctly targeting a TA protein to its appropriate membrane, the mechanisms and signals involved are not fully understood. In this study we identify additional peroxisomal TA proteins, discover more proteins which are shared by multiple organelles and reveal that a combination of TMD hydrophobicity and tail charge determines targeting to distinct organelle locations in mammals...
March 21, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28319028/optically-active-charge-transfer-in-hybrids-of-alq-sub-3-sub-nanoparticles-and-mos-sub-2-sub-monolayer
#3
Ganesh Ghimire, Krisnhna Dhakal, Guru Neupane, Seong Gi Jo, Hyun Kim, Changwon Seo, Young Lee, Jinsoo Joo, Jeongyong Kim
Organic/inorganic hybrid structures have been widely studied because of their enhanced physical and chemical properties. Monolayers of transition metal dichalcogenides (1L-TMDs) and organic nanoparticles can provide a hybridization configuration between zero- and two-dimensional systems with the advantages of convenient preparation and strong interface interaction. Here, we present such a hybrid system made by dispersing π-conjugated organic (tris(8-hydroxyquinoline)aluminum(III)) (Alq<sub>3</sub>) nanoparticles (NPs) on 1L-MoS<sub>2</sub>...
March 20, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28318085/inflammatory-double-hit-model-of-temporomandibular-joint-disorder-with-elevated-ccl2-cxcl9-cxcl10-rantes-and-behavioural-hypersensitivity-in-tnfr1-r2-mice
#4
S L McIlwrath, R Nesemeier, F Ma, H S Oz, L Zhang, K N Westlund
BACKGROUND: Patients with temporomandibular joint disorders (TMD), reactive arthritis and rheumatoid arthritis often have combined etiology of hereditary and microenvironmental factors contributing to joint pain. Multiple clinical and animal studies indicate 'double-hit' inflammatory insults can cause chronic inflammation. The first inflammatory insult primes the immune system and subsequent insults elicit amplified responses. The present 'double hit' study produced a chronic orofacial pain model in mice with genetic deletion of both TNFα receptors (TNFR1/R2-/-), investigating the main nociceptive signalling pathways in comparisons to wild type mice...
March 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28317439/patterns-of-cervical-and-masticatory-impairment-in-subgroups-of-people-with-temporomandibular-disorders-an-explorative-approach-based-on-factor-analysis
#5
Nikolaus Ballenberger, Harry von Piekartz, Mira Danzeisen, Toby Hall
OBJECTIVES: To identify clinical patterns of impairment affecting the cervical spine and masticatory systems in different subcategories of temporomandibular disorder (TMD) by an explorative data-driven approach. METHODS: For this observational study, 144 subjects were subdivided according to Research Diagnostic Criteria for TMDs into: Healthy controls, temporomandibular joint (TMJ) signs without symptoms, TMJ affected, temporomandibular muscles affected, or TMJ and muscles affected...
March 20, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28317010/statistical-downscaling-for-rainfall-forecasts-using-modified-constructed-analog-method-in-thailand
#6
Patchalai Anuchaivong, Dusadee Sukawat, Anirut Luadsong
The simulations of rainfall from historical data were created in this study by using statistical downscaling. Statistical downscaling techniques are based on a relationship between the variables that are solved by the General Circulation Models (GCMs) and the observed predictions. The Modified Constructed Analog Method (MCAM) is a technique in downscaling estimation, suitable for rainfall simulation accuracy using weather forecasting. In this research, the MCAM was used to calculate the Euclidean distance to obtain the number of analog days...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28306240/atomic-layer-etching-mechanism-of-mos2-for-nano-devices
#7
Ki Seok Kim, Ki Hyun Kim, Yeonsig Nam, Jaeho Jeon, Soonmin Yim, Eric Singh, Jin Yong Lee, Sungjoo Lee, Yeon Sik Jung, Geun Young Yeom, Dong Woo Kim
Among the layered transition metal dichalcogenides (TMDs), which can form stable two-dimensional crystal structures, molybdenum disulfide (MoS2) has been intensively investigated in various electronic and optoelectronic applications, according to different band-gap energies from 1.29 eV to 1.9 eV as the number of layers is decreased, due to its unique properties. To control the MoS2 layers, atomic layer etching (ALE), a cyclic etching consisting of a radical-adsorption step such as Cl adsorption and a reacted-compound desorption step that is through a low-energy Ar(+)-ion exposure, can be a highly effective technique that avoids the inducement of damage and the contamination that are from the reactive steps...
March 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28301687/effect-of-high-frequency-bio-oxidative-ozone-therapy-for-masticatory-muscle-pain-a-double-blind-randomized-clinical-trial
#8
Tamer Celakil, Almina Muric, Bilge Gokcen Roehlig, Gulumser Evlioglu, Haluk Keskin
OBJECTIVES: To evaluate the effect of bio-oxidative ozone application at the points of greatest pain in patients with chronic masticatory muscle pain. METHODS: A total number of 40 (40 women, with a mean age of 31.7) were selected after the diagnosis of myofacial pain dysfunction syndrome according to the Research Diagnostic Criteria for Temporomandibular Disorder (RDC/TMD). The patients were randomly divided into two groups; patients received the ozone therapy at the point of greatest pain, ozone group (n = 20); patients received the sham ozone therapy at the point of greatest pain, placebo group (n = 20)...
March 16, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28296738/clinical-efficacy-of-a-centric-relation-occlusal-splint-and-intra-articular-liquid-phase-concentrated-growth-factor-injection-for-the-treatment-of-temporomandibular-disorders
#9
Jung-Wu Yang, Yi-Chia Huang, Shang-Liang Wu, Shun-Yao Ko, Chiang-Chin Tsai
The agony that accompanies the incidence and symptoms of temporomandibular disorders (TMDs) is an important concern in the oral and maxillofacial region. The objective of this study was to explore the clinical findings after centric relation occlusal splint (CROS) treatment and intra-articular injection treatment with liquid phase concentrated growth factors (LPCGFs) in patients with disc displacement without reduction (DDWOR).The group under investigation of this retrospective cohort study included patients with DDWOR who received treatment from April 2014 until March 2016...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28294697/efficacy-of-low-level-laser-therapy-in-subjective-tinnitus-patients-with-temporomandibular-disorders
#10
Nermin Demirkol, Aslihan Usumez, Mehmet Demirkol, Fatih Sari, Cihan Akcaboy
OBJECTIVE AND BACKGROUND: Tinnitus is an apparent sound, perceived in the ear with no stimulus. It has been described as a sound originating from the brain. It affects 17% of the general population. Etiological factors for tinnitus include temporomandibular joint disorders (TMJ, TMD) and Costen's syndrome. The aim of treatment is to eliminate the tinnitus or at least decrease its apparent volume. MATERIALS AND METHODS: In total, 46 patients referred to our department with bilateral subjective tinnitus with TMDs were selected for this study...
March 14, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28294223/an-origin-of-unintentional-doping-in-transition-metal-dichalcogenides-the-role-of-hydrogen-impurities
#11
Youngho Kang, Seungwu Han
We theoretically elucidate the origin of unintentional doping in two-dimensional transition-metal dichalcogenides (TMDs), which has been consistently reported by experiment, but which still remains unclear. Our explanation is based on the charge transfer between TMDs and the underlying SiO2 in which hydrogen impurities with a negative-U property pin the Fermi level of the SiO2 as well as adjacent TMD layers. Using first-principles calculations, we obtain the pinning point of the Fermi level from the charge transition level of the hydrogen in the SiO2, ε(+/-), and align it with respect to the band-edge positions of monolayer TMDs...
March 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/28291355/the-conformation-of-the-epidermal-growth-factor-receptor-transmembrane-domain-dimer-dynamically-adapts-to-the-local-membrane-environment
#12
Eduard V Bocharov, Pavel E Bragin, Konstantin V Pavlov, Olga V Bocharova, Konstantin S Mineev, Anton A Polyansky, Pavel E Volynsky, Roman G Efremov, Alexander S Arseniev
The epidermal growth factor receptor (EGFR) family is an important class of receptor tyrosine kinases, mediating a variety of cellular responses in normal biological processes and in pathological states of multicellular organisms. Different modes of dimerization of the human EGFR transmembrane domain (TMD) in different membrane mimetics recently prompted us to propose a novel signal transduction mechanism based on protein-lipid interaction. However, the experimental evidence for it was originally obtained with slightly different TMD fragments used in the two different mimetics, compromising the validity of the comparison...
March 17, 2017: Biochemistry
https://www.readbyqxmd.com/read/28290229/incobotulinumtoxina-injection-for-temporomandibular-joint-disorder
#13
Amit A Patel, Michael Z Lerner, Andrew Blitzer
OBJECTIVES: Temporomandibular disorder (TMD) involves dysfunction of the temporomandibular joint and associated muscles of mastication causing pain with chewing, limitation of jaw movement, and pain. While the exact pathophysiology of TMD is not completely understood, it is thought that hyperfunction of the muscles of mastication places stress on the temporomandibular joint, leading to degeneration of the joint and associated symptoms. We hypothesize that chemodenervation of the muscles of mastication with IncobotulinumtoxinA (Xeomin) will decrease the stress on the temporomandibular joint and improve pain associated with temporomandibular joint and muscle disorder (TMJD)...
April 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28289287/energy-transduction-and-alternating-access-of-the-mammalian-abc-transporter-p-glycoprotein
#14
Brandy Verhalen, Reza Dastvan, Sundarapandian Thangapandian, Yelena Peskova, Hanane A Koteiche, Robert K Nakamoto, Emad Tajkhorshid, Hassane S Mchaourab
ATP binding cassette (ABC) transporters of the exporter class harness the energy of ATP hydrolysis in the nucleotide-binding domains (NBDs) to power the energetically uphill efflux of substrates by a dedicated transmembrane domain (TMD). Although numerous investigations have described the mechanism of ATP hydrolysis and defined the architecture of ABC exporters, a detailed structural dynamic understanding of the transduction of ATP energy to the work of substrate translocation remains elusive. Here we used double electron-electron resonance and molecular dynamics simulations to describe the ATP- and substrate-coupled conformational cycle of the mouse ABC efflux transporter P-glycoprotein (Pgp; also known as ABCB1), which has a central role in the clearance of xenobiotics and in cancer resistance to chemotherapy...
March 13, 2017: Nature
https://www.readbyqxmd.com/read/28288652/conserved-residues-within-the-hiv-1-vpu-transmembrane-proximal-hinge-region-modulate-bst2-binding-and-antagonism
#15
Sabelo Lukhele, Éric A Cohen
BACKGROUND: BST2 inhibits HIV-1 release by tethering nascent virions to the surface of infected cells. HIV-1 Vpu overcomes this restriction by removing BST2 from viral budding sites via BST2 intracellular trapping and sequestration, surface downregulation and/or displacement mechanisms. Vpu is composed of a short luminal tail, a transmembrane domain (TMD) and a cytoplasmic hinge region that is followed by two helices. BST2 counteraction relies on the ability of Vpu to physically bind BST2 through TMD interactions and recruit the clathrin-dependent trafficking machinery via a canonical acidic di-leucine signalling motif within the helix-2 of Vpu...
March 14, 2017: Retrovirology
https://www.readbyqxmd.com/read/28288293/prevalence-of-temporomandibular-dysfunction-and-its-association-with-malocclusion-in-children-an-epidemiologic-study
#16
Fundagül Bilgiç, İbrahim Erhan Gelgör
INTRODUCTION: Malocclusion is one etiological factor of temporomandibular joint disorder (TMD). This study investigates the prevalence of TMD and the relationship between TMD and the type of occlusion. STUDY DESIGN: A sample of 923 children (463 girls and 460 boys, ages 7-12 years old) was grouped not only by chronological age but also by gender. The information was collected on functional occlusion (anterior and lateral sliding, interferences), dental wear, mandibular mobility (maximal opening, deflection, deviation), and temporomandibular joint and muscular pain recorded by palpation...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28288273/defect-coupling-and-sub-angstrom-structural-distortions-in-w1-xmoxs2-monolayers
#17
Amin Azizi, Yuanxi Wang, Greg Stone, Ana Laura Elías, Zhong Lin, Mauricio Terrones, Vincent H Crespi, Nasim Alem
Two-dimensional materials offer a remarkably rich materials platform to study the origin of different material behaviors at the atomic level, and doping provides a key means of tailoring such materials' functional properties. The local atomic structure around such dopants can be critically important in determining the material behavior as it could modulate scattering, catalytic activity, electronic and magnetic properties, etc. Here, using aberration-corrected scanning transmission electron microscopy with sub-Ångstrom resolution in conjunction with density functional theory calculations, we demonstrate a strong coupling between Mo dopants and two types of defects in WS2 monolayers: sulfur mono-vacancies and grain boundaries...
March 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/28287663/tungsten-disulphide-for-ultrashort-pulse-generation-in-all-fiber-lasers
#18
Wenjun Liu, Lihui Pang, Hainian Han, Ke Bi, Ming Lei, Zhiyi Wei
Tungsten disulphide (WS2), which exhibits excellent saturable absorption properties, has attracted much attention in the applications of photonic devices. In this paper, WS2 is applied for the preparation of a saturable absorber (SA). Using the pulsed laser deposition (PLD) method, WS2 is deposited on the side surface of the tapered fiber. In order to obtain larger non-linearity of the SAs with evanescent wave interaction, the tapered fiber had a smaller waist diameter and longer fused zone. Gold film was deposited on the fiber-taper WS2 SAs to improve their reliability and avoid oxidation and corrosion...
March 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/28281764/dynamic-phase-engineering-of-bendable-transition-metal-dichalcogenide-monolayers
#19
Joel Berry, Songsong Zhou, Jian Han, David J Srolovitz, Mikko P Haataja
Current interest in two-dimensional (2D) materials is driven in part by the ability to dramatically alter their optoelectronic properties through strain and phase engineering. A combination of these approaches can be applied in quasi-2D transition metal dichalcogenide (TMD) monolayers to induce displacive structural transformations between semiconducting (H) and metallic/semimetallic (T') phases. We classify such transformations in Group VI TMDs, and formulate a multiscale, first-principles-informed modeling framework to describe evolution of microstructural domain morphologies in elastically bendable 2D monolayers...
March 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28280708/evaluation-of-postoperative-complications-according-to-treatment-of-third-molars-in-mandibular-angle-fracture
#20
Hye-Youn Lim, Tae-Young Jung, Sang-Jun Park
OBJECTIVES: The aim of this study was to evaluate the implication of third molars in postoperative complications of mandibular angle fracture with open reduction and internal fixation (ORIF). MATERIALS AND METHODS: Data were collected on patients who presented with mandibular angle fracture at our Department of Oral and Maxillofacial Surgery between January 2011 and December 2015. Of the 63 total patients who underwent ORIF and perioperative intermaxillary fixation (IMF) with an arch bar, 49 patients were identified as having third molars in the fracture line and were followed up with until plate removal...
February 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
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