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https://www.readbyqxmd.com/read/27911133/changes-in-cervical-movement-impairment-and-pain-following-orofacial-treatment-in-patients-with-chronic-arthralgic-temporomandibular-disorder-with-pain-a-prospective-case-series
#1
Francis Grondin, Toby Hall
The purpose of this study was to investigate the influence of isolated temporomandibular joint (TMJ) manual therapy on pain and range of motion (ROM) of the TMJ and cervical spine including flexion-rotation test (FRT) in people suffering chronic pain arising from chronic arthralgic temporomandibular disorder (TMD). An experienced clinician managed a case series of 12 patients with TMD (mean duration 28.6 months +/- 26.9). The intervention comprised four-weekly sessions of transverse medial accessory TMJ mobilization and advice...
December 2, 2016: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/27908491/clinical-outcomes-of-botox-injections-for-chronic-temporomandibular-disorders-do-we-understand-how-botox-works-on-muscle-pain-and-the-brain
#2
S T Connelly, J Myung, R Gupta, G M Tartaglia, A Gizdulich, J Yang, R Silva
The main objective of this retrospective review was to analyze the clinical outcomes following the use of botulinum toxin (onabotulinumtoxinA, Botox) injections to relieve the symptoms of chronic temporomandibular disorders (TMD). Seventy-one patients with a diagnosis of TMD (according to the RDC/TMD international consortium) associated with or without bruxism and refractory to conventional treatment (e.g. oral appliances, physiotherapy, etc.) received Botox injections into the temporalis and masseter muscles...
November 28, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27905530/structural-basis-for-broad-neutralization-of-hiv-1-through-the-molecular-recognition-of-10e8-helical-epitope-at-the-membrane-interface
#3
Edurne Rujas, Jose M M Caaveiro, Angélica Partida-Hanon, Naveed Gulzar, Koldo Morante, Beatriz Apellániz, Miguel García-Porras, Marta Bruix, Kouhei Tsumoto, Jamie K Scott, M Ángeles Jiménez, José L Nieva
The mechanism by which the HIV-1 MPER epitope is recognized by the potent neutralizing antibody 10E8 at membrane interfaces remains poorly understood. To solve this problem, we have optimized a 10E8 peptide epitope and analyzed the structure and binding activities of the antibody in membrane and membrane-like environments. The X-ray crystal structure of the Fab-peptide complex in detergents revealed for the first time that the epitope of 10E8 comprises a continuous helix spanning the gp41 MPER/transmembrane domain junction (MPER-N-TMD; Env residues 671-687)...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27903463/her2-transmembrane-mutations-v659-g660-that-stabilize-homo-and-hetero-dimerization-are-rare-oncogenic-drivers-in-lung-adenocarcinoma-that-respond-to-afatinib
#4
Sai-Hong Ignatius Ou, Alexa B Schrock, Eduard V Bocharov, Samuel J Klempner, Carolina Kawamura Haddad, Gary Steinecker, Melissa Johnson, Barbara J Gitlitz, Jon Chung, Paulo V Campregher, Jeffrey S Ross, Philip J Stephens, Vincent A Miller, James H Suh, Siraj M Ali, Vamsidhar Velcheti
INTRODUCTION: HER2 transmembrane domain (TMD) mutations (HER2(V659E), HER2(G660D)) have previously been identified in lung adenocarcinomas, but their frequency and clinical significance is unknown. METHODS: We prospectively analyzed 8,551 consecutive lung adenocarcinomas using hybrid-capture based comprehensive genomic profiling (CGP) at the request of the individual treating physicians for the purpose of making therapy decisions. RESULTS: We identified 15 cases (0...
November 26, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27903265/associations-among-oral-health-related-quality-of-life-subjective-symptoms-clinical-status-and-self-rated-oral-health-in-japanese-university-students-a-cross-sectional-study
#5
Mayu Yamane-Takeuchi, Daisuke Ekuni, Shinsuke Mizutani, Kota Kataoka, Ayano Taniguchi-Tabata, Tetsuji Azuma, Michiko Furuta, Takaaki Tomofuji, Yoshiaki Iwasaki, Manabu Morita
BACKGROUND: The present study aimed to elucidate the associations among self-rated oral health, clinical oral health status, oral health behaviors, subjective oral symptoms, and oral health-related quality of life (OHRQoL) in a group of Japanese university students. METHODS: Of 2051 participants, 2027 (98.83%) students received an optional oral examination and answered a questionnaire including items regarding age, sex, self-rated oral health, oral health behaviors, subjective oral symptoms, and OHRQoL [The Oral Health Impact Profile (OHIP)-14]...
November 30, 2016: BMC Oral Health
https://www.readbyqxmd.com/read/27900241/changes-in-the-salivary-oxidative-status-in-individuals-with-temporomandibular-disorders-and-pain
#6
Claudyane de Almeida, José Miguel Amenábar
Temporomandibular joint disorders are quite common among the general public. Free radicals may play a role in the pathogenesis of joint diseases, and the oxidative stress is an important aspect in the mechanism of TMDs. The use of new biotechnologies has enabled the use of saliva as a diagnostic method. This is the first paper that aims to investigate changes in the oxidative status, through saliva analysis, in individuals who suffer from temporomandibular disorder and pain. Sixty individuals, 54 women and 06 men, aged between 10 and 60, participated in this research...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27898256/comparative-study-of-the-physiotherapeutic-and-drug-protocol-and-low-level-laser-irradiation-in-the-treatment-of-pain-associated-with-temporomandibular-dysfunction
#7
Marcos Fernando Xisto Braga Cavalcanti, Uoston Holder Silva, Ernesto Cesar Pinto Leal-Junior, Rodrigo A B Lopes-Martins, Rodrigo Labat Marcos, Rodney Capp Pallotta, Francesca Diomede, Oriana Trubiani, Natalia De Isla, Lucio Frigo
BACKGROUND: The temporomandibular joint (TMJ) is a structure of the craniofacial complex affected by neurological diseases. Orthopedic and musculoskeletal changes can also cause temporomandibular disorders (TMD) and pain. Low-level laser (LLL) therapy has been studied in the treatment of temporomandibular jaw (TMJ) dysfunction, and controversial results were obtained. OBJECTIVE: The objective of this work was comparing the physiotherapeutic and drug protocol (PDP) to LLL therapy in the treatment of pain associated with TMD...
November 29, 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27892463/reconfigurable-exciton-plasmon-interconversion-for-nanophotonic-circuits
#8
Hyun Seok Lee, Dinh Hoa Luong, Min Su Kim, Youngjo Jin, Hyun Kim, Seokjoon Yun, Young Hee Lee
The recent challenges for improving the operation speed of nanoelectronics have motivated research on manipulating light in on-chip integrated circuits. Hybrid plasmonic waveguides with low-dimensional semiconductors, including quantum dots and quantum wells, are a promising platform for realizing sub-diffraction limited optical components. Meanwhile, two-dimensional transition metal dichalcogenides (TMDs) have received broad interest in optoelectronics owing to tightly bound excitons at room temperature, strong light-matter and exciton-plasmon interactions, available top-down wafer-scale integration, and band-gap tunability...
November 28, 2016: Nature Communications
https://www.readbyqxmd.com/read/27889533/temporomandibular-joint-disorder-management-in-oral-and-maxillofacial%C3%A2-surgery
#9
Louis G Mercuri
PURPOSE: This article discusses why the management of temporomandibular joint disorder (TMD) cases leads to some oral and maxillofacial surgeons to actively avoid attracting such patients to their practices, offers some evidence-based explanations, and provides recommendations for resolution that will benefit not only the specialty but more importantly the patients it serves. MATERIALS AND METHODS: A review of the reasons some surgeons state they do not wish to manage TMD cases is presented, followed by an updated review of the TMD and orthopedic literature discussing not only the importance of a proper diagnosis but also the impact of comorbid conditions, genetics, clinical experience, and patient expectations important to achieving good TMD management outcomes...
November 4, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27880788/micro-ct-vs-whole-body-multirow-detector-ct-for-analysing-bone-regeneration-in-an-animal-model
#10
Oliver Bissinger, Jan S Kirschke, Florian Andreas Probst, Martin Stauber, Klaus-Dietrich Wolff, Bernhard Haller, Carolin Götz, Christian Plank, Andreas Kolk
OBJECTIVES: Compared with multirow detector CT (MDCT), specimen (ex vivo) micro-CT (μCT) has a significantly higher (~ 30 x) spatial resolution and is considered the gold standard for assessing bone above the cellular level. However, it is expensive and time-consuming, and when applied in vivo, the radiation dose accumulates considerably. The aim of this study was to examine whether the lower resolution of the widely used MDCT is sufficient to qualitatively and quantitatively evaluate bone regeneration in rats...
2016: PloS One
https://www.readbyqxmd.com/read/27876452/comparison-of-excursive-occlusal-force-parameters-in-post-orthodontic-and-non-orthodontic-subjects-using-t-scan%C3%A2-iii
#11
Sarah Qadeer, Ahmed A Abbas, Lertrit Sarinnaphakorn, Robert B Kerstein
OBJECTIVE: Published studies indicate that orthodontically treated patients demonstrate increased posterior occlusal friction contributing to temporomandibular disorder (TMD) symptoms. This study investigated measured excursive movement occlusal contact parameters and their association with TMD symptoms between non- and post-orthodontic subjects. METHODS: Twenty-five post-orthodontic and 25 non-orthodontic subjects underwent T-Scan® computerized occlusal analysis to determine their disclusion time (DT), the excursive frictional contacts, and occlusal scheme...
November 23, 2016: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/27870912/atp-hydrolysis-induced-conformational-changes-in-the-vitamin-b12-transporter-btucd-revealed-by-md-simulations
#12
Chao Pan, Jingwei Weng, Wenning Wang
ATP binding cassette (ABC) transporters utilize the energy of ATP hydrolysis to uni-directionally transport substrates across cell membrane. ATP hydrolysis occurs at the nucleotide-binding domain (NBD) dimer interface of ABC transporters, whereas substrate translocation takes place at the translocation pathway between the transmembrane domains (TMDs), which is more than 30 angstroms away from the NBD dimer interface. This raises the question of how the hydrolysis energy released at NBDs is "transmitted" to trigger the conformational changes at TMDs...
2016: PloS One
https://www.readbyqxmd.com/read/27862166/association-between-temporomandibular-disorders-and-pain-in-other-regions-of-the-body
#13
Letícia Ladeira Bonato, Valquiria Quinelato, Patrícia Cataldo de Felipe Cordeiro, Eduardo Branco de Sousa, Ricardo Tesch, Priscila Ladeira Casado
: The pain from temporomandibular disorder (TMD) is often associated on physical symptoms of other chronic pain disorders and comorbidities, such as generalized muscle and joint pain. However, this association is not widely studied. OBJECTIVE: To evaluate the prevalence of comorbid pain in joints, specifically in the the knees, hips, ankles, shoulders, wrists and elbows, in individuals with and without TMD. MATERIALS AND METHOD: We evaluated 337 patients from a public hospital in the city of Rio de Janeiro, Brazil...
November 10, 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27856968/estrogen-induced-monocytic-response-correlates-with-temporomandibular-disorder-pain-a-case-control-study
#14
M C Ribeiro-Dasilva, R B Fillingim, S M Wallet
Temporomandibular disorders (TMD) are a set of conditions characterized by pain and dysfunction in the temporomandibular joint and muscles of mastication. These pain conditions are associated with considerable morbidity, societal costs, and reduced quality of life. The prevalence varies between 4% and 10%, with females at higher risk, and a higher prevalence occurs during reproductive years. The increased prevalence of TMD in females and low prevalence in childhood reinforce that sex hormones, like estrogen, play an important, complex role in the pathophysiology of these disorders...
November 16, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27845033/functional-characterization-of-two-prokaryotic-pentameric-ligand-gated-ion-channel-chimeras-role-of-the-glic-transmembrane-domain-in-proton-sensing
#15
Camille M Hénault, John E Baenziger
With the long-term goal of using a chimeric approach to dissect the distinct lipid sensitivities and thermal stabilities of the pentameric ligand-gated ion channels (pLGIC), GLIC and ELIC, we constructed chimeras by cross-combining their extracellular (ECD) and transmembrane (TMD) domains. As expected, the chimera formed between GLIC-ECD and ELIC-TMD (GE) responded to protons, the agonist for GLIC, but not cysteamine, the agonist for ELIC, although GE exhibited a 25-fold decrease in proton-sensitivity relative to wild type...
November 12, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27836142/prosthodontic-planning-in-patients-with-temporomandibular-disorders-and-or-bruxism-a-systematic-review
#16
REVIEW
Daniele Manfredini, Carlo E Poggio
STATEMENT OF PROBLEM: The presence of temporomandibular disorders (TMDs) and/or bruxism signs and symptoms may present multifaceted concerns for the prosthodontist. PURPOSE: The purpose of this systematic review was to evaluate the relationship between prosthetic rehabilitation and TMDs and bruxism. MATERIAL AND METHODS: Three research questions were identified based on different clinical scenarios. Should prosthodontics be used to treat TMD and/or bruxism? Can prosthodontics cause TMDs and/or bruxism? How can prosthodontics be performed (for prosthetic reasons) in patients with TMDs and/or bruxism? A systematic search in the PubMed database was performed to identify all randomized clinical trials (RCTs) comparing the effectiveness of prosthodontics with that of other treatments in the management of TMDs and/or bruxism (question 1); clinical trials reporting the onset of TMDs and/or bruxism after the execution of prosthetic treatments in healthy individuals (question 2); and RCTs comparing the effectiveness of different prosthodontics strategies in the management of the prosthetic needs in patients with TMDs and/or bruxism (question 3)...
November 8, 2016: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/27836101/tumor-necrosis-factor-alpha-stimulates-cytokine-expression-and-transient-sensitization-of-trigeminal-nociceptive-neurons
#17
Zachary L Durham, Jordan L Hawkins, Paul L Durham
OBJECTIVE: Elevated levels of tumor necrosis factor- alpha (TNF-α) in the capsule of the temporomandibular joint (TMJ) are implicated in the underlying pathology of temporomandibular disorders (TMD). TMD are a group of conditions that result in pain in the TMJ and/or muscles of mastication, and are associated with significant social and economic burdens. The goal of this study was to investigate the effect of elevated TNF-α levels in the TMJ capsule on nocifensive behavioral response to mechanical stimulation of trigeminal neurons and regulation of cytokines within the trigeminal ganglion...
November 4, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27834414/psychosocial-aspects-and-temporomandibular-disorders-in-dental-students
#18
Cibele Oliveira de Melo Rocha, Raniel Fernandes Peixoto, Camila Maria Bastos Machado Resende, Arthur César de Medeiros Alves, Ângelo Giuseppe Roncalli da Oliveira, Gustavo Augusto Seabra Barbosa
OBJECTIVE: Dental students have high levels of anxiety that can affect not only academic performance but also increase the risk for other diseases. It is believed that the increase in the incidence of chronic orofacial pain in temporomandibular disorders (TMDs) may have an impact on the quality of life and general health of subjects. The aim of this study was to evaluate the prevalence of TMD in dental students and its association with general health, quality of life, and anxiety. METHOD AND MATERIALS: Ninety students were evaluated by four questionnaires to determine the prevalence and severity of TMD (Fonseca's questionnaire) and to quantify general health (General Health Questionnaire - GHQ), quality of life (World Health Organization Quality of Life - Brief version - WHOQOL-brief) and anxiety levels (State-Trait Anxiety Index - STAI)...
November 10, 2016: Quintessence International
https://www.readbyqxmd.com/read/27834407/-painful-temporomandibular-dysfunctions-diagnosis-and-treatment
#19
F Lobbezoo, G Aarab, W Knibbe, M Koutris, C J Warnsinck, P Wetselaar, C M Visscher
Painful temporomandibular disorders (TMD pain) are common among the general population. The most common sub diagnoses are myalgia (jaw-muscle pain) and arthralgia (temporomandibular joint pain). The aetiology of TMD pain has a multifactorial nature, and its diagnosis and possible treatment often require a multidisciplinary approach. The most recent insights in the diagnosis and treatment of TMD pain are based on the multidisciplinary guideline 'Chronic Orofacial Pain' that was developed by the Dutch Society of Headache Patients and was published in 2013...
November 2016: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/27829362/castin-a-system-for-comprehensive-analysis-of-cancer-stromal-interactome
#20
Daisuke Komura, Takayuki Isagawa, Kazuki Kishi, Ryohei Suzuki, Reiko Sato, Mariko Tanaka, Hiroto Katoh, Shogo Yamamoto, Kenji Tatsuno, Masashi Fukayama, Hiroyuki Aburatani, Shumpei Ishikawa
BACKGROUND: Cancer microenvironment plays a vital role in cancer development and progression, and cancer-stromal interactions have been recognized as important targets for cancer therapy. However, identifying relevant and druggable cancer-stromal interactions is challenging due to the lack of quantitative methods to analyze whole cancer-stromal interactome. RESULTS: We present CASTIN (CAncer-STromal INteractome analysis), a novel framework for the evaluation of cancer-stromal interactome from RNA-Seq data using cancer xenograft models...
November 9, 2016: BMC Genomics
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