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https://www.readbyqxmd.com/read/27835572/sprouty2-inhibits-amphiregulin-induced-down-regulation-of-e-cadherin-and-cell-invasion-in-human-ovarian-cancer-cells
#1
Jung-Chien Cheng, Hsun-Ming Chang, Siyuan Xiong, Wai-Kin So, Peter C K Leung
Similar to Drosophila Sprouty (SPRY), mammalian SPRY proteins inhibit the receptor tyrosine kinase-mediated activation of cellular signaling pathways. SPRY2 expression levels have been shown to be down-regulated in human ovarian cancer, and patients with low SPRY2 expression have significantly poorer survival than those with high SPRY2 expression. In addition, epidermal growth factor receptor (EGFR) is overexpressed in human ovarian cancer and is associated with more aggressive clinical behavior and a poor prognosis...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27748374/transcriptional-regulation-of-sprouty-2-by-myb-influences-myeloid-cell-proliferation-and-stem-cell-properties-by-enhancing-responsiveness-to-il-3
#2
M Clarke, G Volpe, L Sheriff, D Walton, C Ward, W Wei, S Dumon, P García, J Frampton
Myeloproliferative neoplasms (MPN), which overproduce blood cells in the bone marrow, have recently been linked with a genetically determined decrease in expression of the MYB transcription factor. Here, we use a mouse MYB knockdown model with an MPN-like phenotype to show how lower levels of MYB lead to stem cell characteristics in myeloid progenitors. The altered progenitor properties feature elevated cytokine responsiveness, especially to IL-3, which results from increased receptor expression and increased MAPK activity leading to enhanced phosphorylation of a key regulator of protein synthesis, ribosomal protein S6...
October 17, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27737732/anacardic-acid-inhibits-gelatinases-through-the-regulation-of-spry2-mmp-14-emmprin-and-reck
#3
Jyotsna Nambiar, Chinchu Bose, Meera Venugopal, Asoke Banerji, Tarun B Patel, Geetha B Kumar, Bipin G Nair
Earlier studies from our laboratory have identified Anacardic acid (AA) as a potent inhibitor of gelatinases (MMP-2 and 9), which are over-expressed in a wide variety of cancers (Omanakuttan et al., 2012). Disruption of the finely tuned matrix metalloproteinase (MMP) activator/inhibitor balance plays a decisive role in determining the fate of the cell. The present study demonstrates for the first time, that in addition to regulating the expression as well as activity of gelatinases, AA also inhibits the expression of its endogenous activators like MMP-14 and Extracellular Matrix MetalloProteinase Inducer (EMMPRIN) and induces the expression of its endogenous inhibitor, REversion-inducing Cysteine-rich protein with Kazal motifs (RECK)...
October 11, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27686255/altered-regulation-of-the-spry2-dyrk1a-pp2a-triad-by-homocysteine-impairs-neural-progenitor-cell-proliferation
#4
Luis G Rabaneda, Noelia Geribaldi-Doldán, Maribel Murillo-Carretero, Manuel Carrasco, José M Martínez-Salas, Cristina Verástegui, Carmen Castro
Hyperhomocysteinemia reduces neurogenesis in the adult mouse brain. Homocysteine (Hcy) inhibits postnatal neural progenitor cell (NPC) proliferation by specifically impairing the fibroblast growth factor receptor (FGFR)-Erk1/2-cyclin E signaling pathway. We demonstrate herein that the inhibition of FGFR-dependent NPC proliferation induced by Hcy is mediated by its capacity to alter the cellular methylation potential. Our results show that this alteration modified the expression pattern and activity of Sprouty2 (Spry2), a negative regulator of the above mentioned pathway...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27677077/single-nucleotide-polymorphisms-in-microrna-genes-are-associated-with-cervical-cancer-susceptibility-in-a-population-from-xinjiang-uygur
#5
Jie Yang, Zegao Zhang, Wen Guo, Yuhua Ma, Raila Muhammed Emin, Karima Abudubari, Glmira Hayrat, Hasiyet Wali, Xiaoli Qi, Chunhua Liu, Miaomiao Ma, Pulat Nurbek
The goal of this study was to explore the correlation between single nucleotide polymorphisms (SNPs)and susceptibility to cervical cancer (CC) in a population from Xinjiang Uygur. Participating were 247 patients with CC and 285 healthy women. Fourteen SNPs in nine miRNA genes were selected. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression analysis. Multivariate logistic regression analysis was used to assess the correlation of SNPs with CC. The minor allele "C" of rs300574 in SPRY1 was associated with an increased risk of CC based on analysis of the allele, codominant, recessive and log-additive models, but an opposite result was found with the over-dominant model...
September 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27539669/hcg-induced-sprouty2-mediates-amphiregulin-stimulated-cox-2-pge2-up-regulation-in-human-granulosa-cells-a-potential-mechanism-for-the-ohss
#6
Jung-Chien Cheng, Lanlan Fang, Hsun-Ming Chang, Ying-Pu Sun, Peter C K Leung
Sprouty2 (SPRY2) is an important intracellular regulator for epidermal growth factor receptor (EGFR)-mediated ERK1/2 signaling. In human granulosa cells, although SPRY2 is expressed, its regulation and function remains complete unknown and must be defined. Our previous study has shown that human chorionic gonadotropin (hCG)/luteinizing hormone (LH) up-regulates the expression levels of EGF-like growth factor, amphiregulin (AREG), which subsequently contributes to the hCG/LH-induced COX-2 expression and PGE2 production...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27529420/additive-effects-of-millimeter-waves-and-2-deoxyglucose-co-exposure-on-the-human-keratinocyte-transcriptome
#7
Yonis Soubere Mahamoud, Meziane Aite, Catherine Martin, Maxim Zhadobov, Ronan Sauleau, Yves Le Dréan, Denis Habauzit
Millimeter Waves (MMW) will be used in the next-generation of high-speed wireless technologies, especially in future Ultra-Broadband small cells in 5G cellular networks. Therefore, their biocompatibilities must be evaluated prior to their massive deployment. Using a microarray-based approach, we analyzed modifications to the whole genome of a human keratinocyte model that was exposed at 60.4 GHz-MMW at an incident power density (IPD) of 20 mW/cm2 for 3 hours in athermic conditions. No keratinocyte transcriptome modifications were observed...
2016: PloS One
https://www.readbyqxmd.com/read/27415760/sprouty2-suppresses-epithelial-mesenchymal-transition-of-human-lens-epithelial-cells-through-blockade-of-smad2-and-erk1-2-pathways
#8
Xuhua Tan, Yi Zhu, Chuan Chen, Xiaoyun Chen, Yingyan Qin, Bo Qu, Lixia Luo, Haotian Lin, Mingxing Wu, Weirong Chen, Yizhi Liu
Transforming growth factor β (TGFβ)-induced epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) plays a key role in the pathogenesis of anterior subcapsular cataract (ASC) and capsule opacification. In mouse lens, Sprouty2 (Spry2) has a negative regulatory role on TGFβ signaling. However, the regulation of Spry2 during ASC development and how Spry2 modulates TGFβ signaling pathway in human LECs have not been characterized. Here, we demonstrate that Spry2 expression level is decreased in anterior capsule LECs of ASC patients...
2016: PloS One
https://www.readbyqxmd.com/read/27281823/sprouty2-protein-regulates-hypoxia-inducible-factor-%C3%AE-hif%C3%AE-protein-levels-and-transcription-of-hif%C3%AE-responsive-genes
#9
Kristin C Hicks, Tarun B Patel
The α-subunits of hypoxia-inducible factors (HIF1α and HIF2α) promote transcription of genes that regulate glycolysis and cell survival and growth. Sprouty2 (Spry2) is a modulator of receptor tyrosine kinase signaling and inhibits cell proliferation by a number of different mechanisms. Because of the seemingly opposite actions of HIFα subunits and Spry2 on cellular processes, we investigated whether Spry2 regulates the levels of HIF1α and HIF2α proteins. In cell lines from different types of tumors in which the decreased protein levels of Spry2 have been associated with poor prognosis, silencing of Spry2 elevated HIF1α protein levels...
August 5, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27226339/inhibiting-mir-21-attenuates-experimental-hepatic-fibrosis-by-suppressing-both-the-erk1-pathway-in-hsc-and-hepatocyte-emt
#10
Kaiming Wu, Changhong Ye, Lin Lin, Yimin Chu, Meng Ji, Weiping Dai, Xin Zeng, Yong Lin
MicroRNA-21 (miR-21) has emerged as a critical regulatory molecule and an important serum marker in hepatic fibrogenesis. The aim of the present study was to investigate the role of inhibiting miR-21 on hepatic fibrosis treatment. Serum miR-21 levels in 60 healthy individuals and 180 patients with different stages of liver cirrhosis were examined, miR-21 levels in normal or cirrhotic human liver tissues (n=10 each) were also detected. An adenoviral vector (Ad-TuD-21) carrying the sponging ToughDecoy (TuD)-RNA sequence against miR-21 was constructed to reduce miR-21 expression efficiently in vitro and in vivo Histological and immunohistological examinations were performed to evaluate the inhibitory effects and mechanism of Ad-TuD-21 delivery into carbon tetrachloride (CCl4) induced hepatic fibrosis rats by targeting extracellular signal-regulated kinase 1 (ERK1) signalling in hepatic stellate cells (HSC) and hepatocyte epithelial-mesenchymal transition (EMT)...
August 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27130872/sprouty2-regulates-endochondral-bone-formation-by-modulation-of-rtk-and-bmp-signaling
#11
Adriane Joo, Roger Long, Zhiqiang Cheng, Courtney Alexander, Wenhan Chang, Ophir D Klein
Skeletal development is regulated by the coordinated activity of signaling molecules that are both produced locally by cartilage and bone cells and also circulate systemically. During embryonic development and postnatal bone remodeling, receptor tyrosine kinase (RTK) superfamily members play critical roles in the proliferation, survival, and differentiation of chondrocytes, osteoblasts, osteoclasts, and other bone cells. Recently, several molecules that regulate RTK signaling have been identified, including the four members of the Sprouty (Spry) family (Spry1-4)...
July 2016: Bone
https://www.readbyqxmd.com/read/27078887/assessment-of-tumor-heterogeneity-as-evidenced-by-gene-expression-profiles-pathway-activation-and-gene-copy-number-in-patients-with-multifocal-invasive-lobular-breast-tumors
#12
Nadine Norton, Pooja P Advani, Daniel J Serie, Xochiquetzal J Geiger, Brian M Necela, Bianca C Axenfeld, Jennifer M Kachergus, Ryan W Feathers, Jennifer M Carr, Julia E Crook, Alvaro Moreno-Aspitia, Panos Z Anastasiadis, Edith A Perez, E Aubrey Thompson
BACKGROUND: Invasive lobular carcinoma (ILC) comprises approximately ~10-20% of breast cancers. In general, multifocal/multicentric (MF/MC) breast cancer has been associated with an increased rate of regional lymph node metastases. Tumor heterogeneity between foci represents a largely unstudied source of genomic variation in those rare patients with MF/MC ILC. METHODS: We characterized gene expression and copy number in 2 or more foci from 11 patients with MF/MC ILC (all ER+, HER2-) and adjacent normal tissue...
2016: PloS One
https://www.readbyqxmd.com/read/27046834/an-fgfr1-spry2-signaling-axis-limits-basal-cell-proliferation-in-the-steady-state-airway-epithelium
#13
Gayan I Balasooriya, Jo-Anne Johnson, M Albert Basson, Emma L Rawlins
The steady-state airway epithelium has a low rate of stem cell turnover but can nevertheless mount a rapid proliferative response following injury. This suggests a mechanism to restrain proliferation at steady state. One such mechanism has been identified in skeletal muscle in which pro-proliferative FGFR1 signaling is antagonized by SPRY1 to maintain satellite cell quiescence. Surprisingly, we found that deletion of Fgfr1 or Spry2 in basal cells of the adult mouse trachea caused an increase in steady-state proliferation...
April 4, 2016: Developmental Cell
https://www.readbyqxmd.com/read/27042307/inhibition-of-sprouty2-polarizes-macrophages-toward-an-m2-phenotype-by-stimulation-with-interferon-%C3%AE-and-porphyromonas-gingivalis-lipopolysaccharide
#14
Ryo Atomura, Terukazu Sanui, Takao Fukuda, Urara Tanaka, Kyosuke Toyoda, Takaharu Taketomi, Kensuke Yamamichi, Hajime Akiyama, Fusanori Nishimura
Periodontitis is a chronic inflammatory disorder caused by specific bacteria residing in the biofilm, particularly Porphyromonas gingivalis (Pg). Sprouty2 (Spry2) functions as a negative regulator of the fibroblast growth factor (FGF) signaling pathway. We previously demonstrated that sequestration of Spry2 induced proliferation and osteogenesis in osteoblastic cells by basic FGF (bFGF) and epidermal growth factor (EGF) stimulation in vitro, but diminished cell proliferation in gingival epithelial cells. In addition, Spry2 knockdown in combination with bFGF and EGF stimulation increases periodontal ligament cell proliferation and migration accompanied by prevention of osteoblastic differentiation...
March 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27016275/sprouty2-regulates-proliferation-and-survival-of-multiple-myeloma-by%C3%A2-inhibiting-activation-of-the-erk1-2-pathway-in%C3%A2-vitro-and-in%C3%A2-vivo
#15
Yao Yao, Jianping Luo, Yueping Bian, Yueyue Sun, Min Shi, Dandan Xia, Mingshan Niu, Kai Zhao, Lingyu Zeng, Wei Chen, Zhenyu Li, Kailin Xu
Multiple myeloma (MM) is an incurable disease, and its pathogenesis remains unclear. MicroRNA (miR)-21 was detected at a high level in MM and plays a key role in the pathogenesis of MM. However, Sprouty2 (spry2), a downstream target of miR-21, has low expression, and its mechanism in MM is unknown. We investigated whether spry2 could exert an antimyeloma effect and further studied the potential pathogenesis and progression of MM. To address the functional consequences of spry2, we assessed the expression levels of spry2 in several myeloma cell lines and detected low expression levels in MM cells...
June 2016: Experimental Hematology
https://www.readbyqxmd.com/read/27003116/learning-to-cope-with-stress-modulates-anterior-cingulate-cortex-stargazin-expression-in-monkeys-and-mice
#16
Alex G Lee, Roxanne Capanzana, Jacqueline Brockhurst, Michelle Y Cheng, Christine L Buckmaster, Devin Absher, Alan F Schatzberg, David M Lyons
Intermittent mildly stressful situations provide opportunities to learn, practice, and improve coping with gains in subsequent emotion regulation. Here we investigate the effects of learning to cope with stress on anterior cingulate cortex gene expression in monkeys and mice. Anterior cingulate cortex is involved in learning, memory, cognitive control, and emotion regulation. Monkeys and mice were randomized to either stress coping or no-stress treatment conditions. Profiles of gene expression were acquired with HumanHT-12v4...
May 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/26846382/expression-and-function-of-microrna-27b-in-hepatocellular-carcinoma
#17
Shujie He, Jingyuan Zhang, Juan Lin, Cuisheng Zhang, Shijie Sun
It has been reported that microRNAs (miRs) have key roles in tumorigenesis via inhibition of their target genes. Dysregulation of miR‑27b has been detected in numerous types of human cancer, including hepatocellular carcinoma (HCC); however, the detailed role of miR‑27b in HCC has yet to be elucidated. Reverse transcription‑quantitative polymerase chain reaction and western blotting were performed to examine the mRNA and protein expression levels. Transwell assay and wound healing assay were used to determine cell invasion and migration...
March 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26809508/sprouty-2-a-novel-attenuator-of-b-cell-receptor-and-mapk-erk-signaling-in-cll
#18
Ashima Shukla, Karan Rai, Vipul Shukla, Nagendra K Chaturvedi, R Gregory Bociek, Samuel J Pirruccello, Hamid Band, Runqing Lu, Shantaram S Joshi
Clinical heterogeneity is a major barrier to effective treatment of chronic lymphocytic leukemia (CLL). Emerging evidence suggests that constitutive activation of various signaling pathways like mitogen-activated protein kinase-extracellular signal-regulated kinase (MAPK-Erk) signaling plays a role in the heterogeneous clinical outcome of CLL patients. In this study, we have investigated the role of Sprouty (SPRY)2 as a negative regulator of receptor and nonreceptor tyrosine kinase signaling in the pathogenesis of CLL...
May 12, 2016: Blood
https://www.readbyqxmd.com/read/26781754/upregulation-of-microrna%C3%A2-27b-contributes-to-the-migration-and-invasion-of-gastric-cancer-cells-via-the-inhibition-of-sprouty2%C3%A2-mediated-erk-signaling
#19
Juan Jiang, Bo Yi, Chunxiang Qin, Siqing Ding, Wei Cao
MicroRNAs (miRs) have been demonstrated to be associated with the development, progression and prognosis of gastric cancer. However, the exact role of miR‑27b in the regulation of gastric cancer cells and the underlying mechanisms remain unclear. In the current study, it was demonstrated that miR‑27b was significantly upregulated in gastric cancer tissues and cell lines, compared with their matched normal adjacent tissues and normal gastric epithelial cells, respectively. Luciferase reporter assay data indicated that sprouty2 (SPRY2) is a direct target of miR‑27b, and miR‑27b binds to the 3'‑untranslated region of SPRY2 mRNA...
March 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26655476/sirna-mediated-down-regulation-of-sprouty2-4-diminishes-ischemic-brain-injury
#20
Lars Klimaschewski, Belen Pinar Sueiro, Luis Martinez Millan
Down-regulation of Sprouty proteins promotes axon regeneration in lesioned nerves and prevents neurodegeneration following excitotoxic brain injury. In this study, siRNAs directed against Sprouty2 and -4 were stereotactically injected along with the vasoconstrictive peptide endothelin-1 to create cortical infarcts in the adult rat brain. A single injection of Sprouty2/4 siRNAs (25μM each) significantly decreased Spry2 and Spry4 mRNA levels two days later and diminished the size of the injury area in the subchronic phase following vasoconstriction...
January 26, 2016: Neuroscience Letters
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