keyword
https://read.qxmd.com/read/38595362/contemporary-insights-into-intractable-epilepsy-in-children
#21
JOURNAL ARTICLE
Khaled Saad, Emad H Eldaly, Hazem M Abdelall, Nahed M Abdelgabaar, David M Zaki, Hamad G Dailah, Ahmed Shams-Eldeen, Khalid H Mahmoud
While most children with epilepsy find their seizures manageable through medication, some continue to experience seizures despite trying multiple drugs. Failure of medical treatment often becomes apparent early on, and for these cases, it is advisable to seek further treatment options at a specialized epilepsy center. Such centers offer additional treatments like epilepsy surgery, vagus nerve stimulation, and ketogenic diets. There is no universal definition for what constitutes "medically intractable" epilepsy...
February 2024: Journal of Pharmacy & Bioallied Sciences
https://read.qxmd.com/read/38591502/design-characterization-and-incorporation-of-the-alkaline-aluminosilicate-binder-in-temperature-insulating-composites
#22
JOURNAL ARTICLE
Pavlo Kryvenko, Igor Rudenko, Oleksandr Konstantynovskyi, Oleksandr Gelevera
This paper covers the design of binder formulations and technology for low-energy building materials based on alkaline aluminosilicate binders developed for special uses. The microstructure of the binders was investigated using scanning electron and atomic force microscopy examination techniques. The identification of phase compositions was performed by means of X-ray diffraction. The degree of binding of the alkali metal ions within the binder was determined with the help of chemical analysis of the pore fluid...
January 29, 2024: Materials
https://read.qxmd.com/read/38589829/forces-required-to-dynamize-sliding-screws-in-gamma-nail-and-selfdynamizable-internal-fixator
#23
JOURNAL ARTICLE
Milan M Mitkovic, Nikola D Korunovic, Sasa S Milenkovic, Predrag M Stojiljkovic, Miodrag T Manic, Miroslav D Trajanovic
BACKGROUND: Single limb support phase of the gait-cycle in patients who are treated for a pertrochanteric fracture is characterized by transversal loads acting on the lag screw, tending to block its dynamization. If the simultaneous axial force overcomes transversal loads of the sliding screw, the dynamization can still occur. METHODS: Biomechanical investigation was performed for three types of dynamic implants: Gamma Nail, and two types of Selfdynamizable Internal Fixators (SIF) - SIF-7 (containing two 7 mm non-cannulated sliding screws), and SIF-10 (containing one 10 mm cannulated sliding screw)...
April 8, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38586866/study-of-risk-factors-for-injuries-due-to-cardiopulmonary-resuscitation-with-special-focus-on-the-role-of-the-heart-a-machine-learning-analysis-of-a-prospective-registry-with-multiple-sources-of-information-recapta-study
#24
JOURNAL ARTICLE
Silvia García-Vilana, Vikas Kumar, Saurav Kumar, Eneko Barberia, Inés Landín, Ester Granado-Font, Silvia Solà-Muñoz, Xavier Jiménez-Fàbrega, Alfredo Bardají, Bjarne Madsen Hardig, Youcef Azeli
BACKGROUND: The study of thoracic injuries and biomechanics during CPR requires detailed studies that are very scarce. The role of the heart in CPR biomechanics has not been determined. This study aimed to determine the risk factors importance for serious ribcage damage due to CPR. METHODS: Data were collected from a prospective registry of out-of-hospital cardiac arrest between April 2014 and April 2017. This study included consecutive out-of-hospital CPR attempts undergoing an autopsy study focused on CPR injuries...
March 2024: Resuscitation plus
https://read.qxmd.com/read/38585905/calculating-structure-factors-of-protein-solutions-by-atomistic-modeling-of-protein-protein-interactions
#25
Sanbo Qin, Huan-Xiang Zhou
We present a method, FMAPS(q), for calculating the structure factor, S(q), of a protein solution, by extending our fast Fourier transform-based modeling of atomistic protein-protein interactions (FMAP) approach. The interaction energy consists of steric, nonpolar attractive, and electrostatic terms that are additive among all pairs of atoms between two protein molecules. In the present version, we invoke the free-rotation approximation, such that the structure factor is given by the Fourier transform of the protein center-center distribution function g C (R)...
March 28, 2024: bioRxiv
https://read.qxmd.com/read/38581158/global-assessment-of-the-knowledge-and-confidence-in-managing-allergic-disorders-among-primary-care-pediatricians-across-europe-an-eaaci-task-force-report
#26
JOURNAL ARTICLE
M Cabrera, D Ryan, M Erlewyn-Lajeunesse, M Levin, A Martínez-Cañavate, C Villaizán Pérez, E Angier, J Trujillo, J M Cárdenas-Rebollo, L Reali
BACKGROUND: Pediatricians are often the first point of contact for children in Primary Care (PC), but still perceive gaps in their allergy knowledge. We investigated self-perceived knowledge gaps and educational needs in pediatricians across healthcare systems in Europe so that future educational initiatives may better support the delivery of allergy services in PC. METHOD: A multinational survey was circulated to pediatricians who care for children and adolescents with allergy problems in PC by the EAACI Allergy Educational Needs in Primary Care Pediatricians Task Force from February to March 2023...
April 2024: Pediatric Allergy and Immunology
https://read.qxmd.com/read/38578242/cobalt-mof-based-porous-carbonaceous-spheres-for-multimodal-soft-actuator-exhibiting-intricate-biomimetic-motions
#27
JOURNAL ARTICLE
Ashhad Kamal Taseer, Saewoong Oh, Ji-Seok Kim, Mousumi Garai, Hyunjoon Yoo, Van Hiep Nguyen, Young Yang, Mannan Khan, Manmatha Mahato, Il-Kwon Oh
The advancement of active electrode materials is essential to meet the demand for multifaceted soft robotic interactions. In this study, we report a new type of porous carbonaceous sphere (PCS) for a multimodal soft actuator capable of both magnetoactive and electro-ionic responses. The PCS, derived from the simultaneous oxidative and reductive breakdown of specially designed cobalt-based metal-organic frameworks (Co-MOFs) with varying metal-to-ligand ratios, exhibits a high specific surface area of 529 m2 g-1 and a saturated magnetization of 142...
April 5, 2024: Advanced Materials
https://read.qxmd.com/read/38569612/eccentric-hamstring-strength-imbalance-among-football-and-soccer-athletes
#28
JOURNAL ARTICLE
Elizabeth M Benson, Joseph W Elphingstone, Kyle D Paul, Samuel Schick, Yazen A Shihab, Dan Barlow, Brent A Ponce, Eugene W Brabston, Amit M Momaya
OBJECTIVES: Hamstring strain injuries (HSI) are common among football and soccer athletes. Eccentric strength imbalance is considered a contributing factor for HSI. There is, however, a paucity of data on hamstring imbalances of soccer and American football athletes as they age and advance in skill level. High school athletes will display greater interlimb discrepancies compared with collegiate and professional athletes. In addition, soccer athletes will exhibit greater hamstring asymmetry than American football athletes...
April 2024: Southern Medical Journal
https://read.qxmd.com/read/38569049/irregular-warfare-must-combine-good-medicine-with-both-good-tactics-and-good-strategies-position-paper-by-the-french-special-operations-forces-medical-command
#29
JOURNAL ARTICLE
Pierre Pasquier, Mathieu David, Ludovic Petit, Morgan Chery, Sébastien Habas, Edouard Patey, Sébastien Conort, Nicolas Zeller, Marc-Olivier Gelmann, Sébastien Peyrefitte, Fabrice Castel, Stéphane Travers, Pierre Mahé
INTRODUCTION: Military operations are no longer limited to the application of counterterrorism and counterinsurgency strategies; they are now characterized by hybrid, irregular, and unconventional features. While some authors have indicated the need for medical support to adapt to these new modes of military operations, they have focused mainly on the tactical level of care on the battlefield. As Sun Tzu states, "Strategy without tactics is the slowest route to victory. Tactics without strategy is the noise before defeat," further proposals are still needed on the application of both medical tactics and medical strategies in irregular warfare...
April 1, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38563089/she-made-it-with-her-friend-how-social-object-history-influences-children-s-thinking-about-the-value-of-digital-objects
#30
JOURNAL ARTICLE
Keiana Price, Jasmine M DeJesus, Shaylene E Nancekivell
Two studies examine how social object histories from collaborative experiences influenced North American children (N = 160, 5-10 years) thinking about the value of digital objects (48% male/51% female; 51% White/24% Black/11% Asian). With forced-choice judgments, Study 1 found (moderate-large effects) that children viewed digital and physical objects with social histories as more special than objects without such histories. On a 10-point scale, Study 2 found (large effects) that children rated digital objects with positive social histories as more special than objects with negative ones...
April 2, 2024: Child Development
https://read.qxmd.com/read/38561774/workforce-strategies-during-the-first-wave-of-the-covid-19-pandemic-a-retrospective-online-survey-at-intensive-care-units-in-germany
#31
JOURNAL ARTICLE
Lara C Stroth, Franziska Jahns, Berit Bode, Maike Stender, Michelle Schmidt, Heiko Baschnegger, Nurith Epstein, Benedikt Sandmeyer, Carla Nau
BACKGROUND: As the COVID-19 pandemic swept across the globe at the beginning of 2020, healthcare systems were forced to rapidly adapt and expand to meet the sudden surge in demand for intensive care services. This study is the first systematic analysis of the strategies employed by German hospitals to recruit personnel and expand bed capacities during the first wave of the pandemic, and to evaluate the effectiveness of those recruitment measures. METHODS: 152 German hospitals with intensive care capacities were selected and invited to participate in an online-based retrospective survey...
April 1, 2024: BMC Health Services Research
https://read.qxmd.com/read/38561703/determinants-of-self-rated-health-among-highly-educated-ukrainian-women-refugees-in-czechia-analysis-based-on-cross-sectional-study-in-2022
#32
JOURNAL ARTICLE
Ivana Kulhánová, Michala Lustigová, Dušan Drbohlav, Yana Leontiyeva, Dagmar Dzúrová
BACKGROUND: Russia's military aggression against Ukraine set in motion a large number of refugees. Considerable amount of them came and stayed in Czechia. Refugees represent special vulnerable individuals often affected by war physically and psychologically. Due to the national regulations not allowing most of Ukrainian men aged 18-60 to leave the country, nowadays Ukrainian forced migration is relatively young and strongly gendered. Evidence suggests the higher probability for searching the safe refuge abroad among Ukrainian women with small children as well as those with relatively higher economic and cultural capital...
April 1, 2024: BMC Women's Health
https://read.qxmd.com/read/38559720/nucleosome-dynamics-derived-at-the-single-molecule-level-bridges-its-structures-and-functions
#33
REVIEW
Ping Chen, Guohong Li, Wei Li
Nucleosome, the building block of chromatin, plays pivotal roles in all DNA-related processes. While cryogenic-electron microscopy (cryo-EM) has significantly advanced our understanding of nucleosome structures, the emerging field of single-molecule force spectroscopy is illuminating their dynamic properties. This technique is crucial for revealing how nucleosome behavior is influenced by chaperones, remodelers, histone variants, and post-translational modifications, particularly in their folding and unfolding mechanisms under tension...
March 25, 2024: JACS Au
https://read.qxmd.com/read/38559627/assessing-cardiac-contractility-from-single-molecules-to-whole-hearts
#34
REVIEW
Ankit Garg, Kory J Lavine, Michael J Greenberg
Fundamentally, the heart needs to generate sufficient force and power output to dynamically meet the needs of the body. Cardiomyocytes contain specialized structures referred to as sarcomeres that power and regulate contraction. Disruption of sarcomeric function or regulation impairs contractility and leads to cardiomyopathies and heart failure. Basic, translational, and clinical studies have adapted numerous methods to assess cardiac contraction in a variety of pathophysiological contexts. These tools measure aspects of cardiac contraction at different scales ranging from single molecules to whole organisms...
March 2024: JACC. Basic to Translational Science
https://read.qxmd.com/read/38557710/particle-separator-with-vortex-claw-an-efficient-and-new-technology
#35
JOURNAL ARTICLE
Cheng He, Padala Chittibabu, David Nguyen, Quintin Rochfort
Despite facing many challenges, the exploration of using natural forces and mechanisms besides gravity to enhance particle settling has never ceased. A novel particle separator design, which utilizes multiple vortexes to enhance particle settling, was proposed in this study. The basic principle is using the fluid's energy to generate small swirling currents in a specially designed vortex claw generator. These currents bring suspended particles from the rapid and turbulent inflow to relatively quiet water regions, separating them from the main flows and reducing their travel distance to the wall...
March 2024: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://read.qxmd.com/read/38556752/unbiased-comparison-between-theoretical-and-experimental-molecular-structures-and-properties-toward-an-accurate-reduced-cost-evaluation-of-vibrational-contributions
#36
JOURNAL ARTICLE
Marco Mendolicchio, Vincenzo Barone
The tremendous development of hardware and software is constantly increasing the role of quantum chemical (QC) computations in the assignment and interpretation of experimental results. However, an unbiased comparison between theory and experiment requires the proper account of vibrational averaging effects. In particular, high-resolution spectra in the gas phase are now available for molecules containing up to about 50 atoms, which are too large for a brute-force approach with the available QC methods of sufficient accuracy...
March 31, 2024: Journal of Chemical Theory and Computation
https://read.qxmd.com/read/38554275/addressing-differences-in-knowledge-and-experience-in-trauma-care-capabilities-among-an-international-team-of-military-medical-care-providers-in-a-deployed-setting
#37
JOURNAL ARTICLE
Sarah Holvelinsky, Taylor Travers, Joshua B Stierwalt, Paul Schunk, Brian Patrick Murray
Military medical personnel are crucial in providing life-saving care at the point of injury (POI) in challenging environments such as combat zones and disaster areas. This article examines the specialized training US Military medical personnel undergo before deployment and the increasing trend of deploying as part of multinational forces in operations like those in Afghanistan with NATO and non-NATO countries. Integrating medical teams from diverse backgrounds poses significant challenges in maintaining a cohesive and efficient team due to varying trauma management training standards and medical practices among the allied forces...
March 30, 2024: Military Medicine
https://read.qxmd.com/read/38553989/cumulative-blast-impulse-is-predictive-for-changes-in-chronic-neurobehavioral-symptoms-following-low-level-blast-exposure-during-military-training
#38
JOURNAL ARTICLE
Cory McEvoy, Adam Crabtree, John Case, Gary E Means, Peter Muench, Ronald G Thomas, Rebecca A Ivory, Jason Mihalik, James S Meabon
INTRODUCTION: Cumulative low-level blast exposure during military training may be a significant occupational hazard, increasing the risk of poor long-term outcomes in brain function. US Public Law 116-92 section 717 mandates that US Department of Defense agencies document the blast exposure of each Service member to help inform later disability and health care decisions. However, which empirical measures of training blast exposure, such as the number of incidents, peak overpressure, or impulse, best inform changes in the neurobehavioral symptoms reflecting brain health have not been established...
March 29, 2024: Military Medicine
https://read.qxmd.com/read/38541606/what-is-life-rethinking-biology-in-light-of-fundamental-parameters
#39
REVIEW
Jacques Fantini, Mélanie Matveeva, Marine Lefebvre, Henri Chahinian
Defining life is an arduous task that has puzzled philosophers and scientists for centuries. Yet biology suffers from a lack of clear definition, putting biologists in a paradoxical situation where one can describe at the atomic level complex objects that remain globally poorly defined. One could assume that such descriptions make it possible to perfectly characterize living systems. However, many cases of misinterpretation put this assumption into perspective. In this article, we focus on critical parameters such as time, water, entropy, space, quantum properties, and electrostatic potential to redefine the nature of living matter, with special emphasis on biological coding...
February 20, 2024: Life
https://read.qxmd.com/read/38540852/possible-role-of-high-molecular-weight-salivary-proteins-in-astringency-development
#40
JOURNAL ARTICLE
Elvira Manjón, Ignacio García-Estévez, María Teresa Escribano-Bailón
Since the initial findings that food tannin/salivary protein interaction and subsequent precipitation is the main cause of the astringency development, numerous studies have concentrated on the supramolecular characterization of these bindings. Most of these works have focused on the low-molecular-weight salivary proteins, in particular proline-rich proteins, hardly considering the involvement of the high-molecular-weight salivary proteins (HMWSPs ). Herein, different techniques such as fluorescence quenching, Isothermal Titration Calorimetry and HPLC-MS-DAD were employed to determine the occurrence of molecular interactions between three HMWSPs , namely, mucin, α-amylase and albumin, and a complex extract of tannins composed mainly of flavan-3-ols...
March 13, 2024: Foods (Basel, Switzerland)
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