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Fetal balloon aortic valvuloplasty

Sun-Young Yoon, Hye-Sung Won, Mi-Young Lee, Min Kyong Cho, Euiseok Jung, Ki-Soo Kim, Young-Hwue Kim
Prenatal intervention of severe fetal aortic valve stenosis by ultrasound-guided percutaneous balloon valvuloplasty has been performed to prevent the progression to hypoplastic left heart syndrome, and achieve biventricular circulation in neonates. Here we report a case of fetal aortic valvuloplasty prenatally diagnosed with aortic stenosis at 24 weeks of gestation and showed worsening features on a follow-up echocardiography. Prenatal aortic valvuloplasty was performed at 29 weeks of gestation, and was a technical success...
January 2017: Obstetrics & Gynecology Science
Michael O Murphy, Hannah Bellsham-Revell, Gareth J Morgan, Thomas Krasemann, Eric Rosenthal, Shakeel A Qureshi, Caner Salih, Conal B Austin, David R Anderson
BACKGROUND: Hybrid procedure offers patients with severe congenital heart disease an alternative initial procedure to conventional surgical reconstruction. We report the midterm outcomes of a cohort of neonates who had a hybrid procedure for variants of hypoplastic left heart syndrome because they were at high risk for the Norwood procedure. METHODS: Between December 2005 and January 2013, 41 neonates underwent bilateral pulmonary artery banding followed by ductal stenting by means of a sternotomy at a median age of 6 days (range, 2 to 18 days) and weight of 2...
December 2015: Annals of Thoracic Surgery
Marzena Dębska, Joanna Szymkiewicz-Dangel, Adam Koleśnik, Piotr Kretowicz, Beata Rebizant, Jacek Witwicki, Romuald Dębski
OBJECTIVE: The aim of the study was to analyze types and methods of intrauterine fetal cardiac interventions performed between June 2011 and December 2013, and to assess the perinatal management of the neonates. METHODS: The program was developed after analysis of the available literature, practical individual training in Linz, Austria, and simulation of the procedure in a dissecting-room. The rules for anesthesia in pregnant women and their fetuses were developed...
April 2015: Ginekologia Polska
C Wohlmuth, G Tulzer, W Arzt, R Gitter, D Wertaschnigg
OBJECTIVES: Fetal cardiac interventions have the potential to alter natural disease progression and reduce morbidity and mortality in children. Although there are already encouraging data on fetal outcome, information on maternal morbidity and mortality after intervention is scarce. The aim of the present study was to assess maternal aspects, pregnancy-associated risks and adverse events in 53 intrauterine cardiac interventions. METHODS: Between October 2000 and December 2012, 53 fetal cardiac interventions were performed in 47 patients (43 aortic valve dilations in 39 patients, seven pulmonary valve dilations in six patients and three balloon atrioseptostomies in two patients)...
November 2014: Ultrasound in Obstetrics & Gynecology
Kevin G Friedman, David Schidlow, Lindsay Freud, Maria Escobar-Diaz, Wayne Tworetzky
Fetal aortic balloon valvuloplasty (FAV) has shown promise in averting progression of midgestation aortic stenosis (AS) to hypoplastic left heart syndrome in a subset of patients. Patients who achieve biventricular circulation after FAV frequently have left ventricular (LV) diastolic dysfunction (DD). This study evaluates DD in fetuses with AS by comparing echocardiographic indices of LV diastolic function in fetuses underwent FAV (n = 20) with controls (n = 40) and evaluates for LV factors associated with DD in patients with FAV...
July 1, 2014: American Journal of Cardiology
Hongyu Duan, Kaiyu Zhou, Yimin Hua
No abstract text is available yet for this article.
January 2014: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Tetsuko Ishii, Doff B McElhinney, David M Harrild, Edward N Marcus, David J Sahn, Uyen Truong, Wayne Tworetzky
OBJECTIVE: The impact of prenatal intervention on fetal cardiac function has not been well defined. We assessed standard ventricular function parameters and strain in fetuses with evolving hypoplastic left heart syndrome (HLHS) treated with fetal aortic valvuloplasty (fAVP). METHODS: Fetuses with valvar aortic stenosis that underwent fAVP were studied. Echocardiographic images prior to intervention (Pre), within 1 week after fAVP (Post), and at the last prenatal follow-up examination (FU) were analyzed...
2014: Fetal Diagnosis and Therapy
Alan W Nugent, Robert C Kowal, Amy L Juraszek, Catherine Ikemba, Kevin Magee
OBJECTIVE: Fetal cardiac interventions are performed via direct cardiac puncture and are associated with significant fetal morbidity. The feasibility of utilizing magnetic navigation to maneuver a guide wire and balloon across a fetal aortic valve without direct cardiac puncture is tested. METHODS: A fetal heart model was manufactured and placed in a catheterization laboratory equipped with magnetic navigation. Magnetically steerable guide wires along with commercially available coronary balloons were inserted into the model at a site mimicking a hepatic vein...
December 2013: Journal of Maternal-fetal & Neonatal Medicine
Ahmet Gül, Arda Saygılı, Sultan Kavuncuoğlu, Yavuz Ceylan
The mortality and morbidity of fetal aortic stenosis (AS) depend on the degree of the hemodynamic effects of the stenosis, and left ventricular (LV) adaptation, development and function during fetal life. In the case of critical AS, the development of hydrops and death in utero are well recognized entities. A 23-week gestation fetus was diagnosed with critical severe AS, cardiomegaly, a dilated LV with very poor contractility, and mitral regurgitation. There was a reversal of flow in the aortic arch through the ductus arteriosis and a reversed a-wave in the ductus venosus on Doppler examination...
March 2013: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Pablo Marantz, Horacio Aiello, Sofía Grinenco, Gustavo Izbizky, Gabriela Peña, Luis Trentacoste, Miguel Granja, Lucas Otaño
OBJECTIVES: Foetal aortic valvuloplasty has been proposed as a strategy to improve left heart growth and function in foetuses with severe aortic stenosis at risk of progression to hypoplastic left heart syndrome. We report our experience with this intervention. METHODS AND RESULTS: Between 2005 and 2010, five foetuses with aortic stenosis and at risk of progression to hypoplastic left heart syndrome underwent ultrasound-guided percutaneous foetal aortic valvuloplasty...
October 2013: Cardiology in the Young
U Gembruch, A Geipel, U Herberg, C Berg
Fetal cardiac interventions are being performed with growing success by a minimally invasive percutaneous and transthoracic approach. The primary aim of these interventions is to minimise postnatal morbidity and mortality, rarely also to achieve intrauterine survival. Valvuloplasty in utero for severe aortic stenosis is performed in order to achieve sufficient growth of the left ventricle and to make a later biventricular repair possible. In rare cases with hydrops secondary to massive left ventricular dilatation and mitral insufficiency it is used as a salvage therapy...
August 2012: Zeitschrift Für Geburtshilfe und Neonatologie
Kaiyu Zhou, Gang Wu, Yifei Li, Liang Zhao, Rong Zhou, Qi Zhu, Xupei Huang, Dezhi Mu, Yimin Hua
BACKGROUND: Intrauterine balloon aortic valvuloplasty (IUBAV) has been used for critical aortic stenosis. However, it is necessary to determine the fetal impairments such as preterm birth after this approach and to find a way to prevent or reduce them. METHODS: In the present study, we evaluated the therapeutic value of indomethacin (IDM) and dexamethasone (DXS) on reducing the preterm birth rate in experimental goats after IUBAV. RESULTS: Our results indicated that the administration of IDM/DXS significantly reduced the rate of premature birth...
2012: Journal of Biomedical Science
Michael L Rigby
Successful treatment of severe aortic (AS) or pulmonary valve (PS) stenosis by balloon valvuloplasty in term neonates is well-established. Sometimes, AS or PS diagnosed antenatally, progresses to severe left or right ventricular hypoplasia respectively. Successful fetal balloon valvuloplasty cannot be assumed to significantly change the natural history. In this review of premature infants, balloon valvuloplasty was used in extremely small babies. Five with severe AS (32 to 36 weeks, birth weight 1.4 to 1.9 kg) had percutaneous balloon aortic valvuloplasty during the first 10 days of life...
May 2012: Early Human Development
Lindsey D Allan
The idea of prenatal intervention in congenital heart defects was put forward over 20 years ago, arising from the observation that some forms of cardiac malformation progressed in severity as pregnancy advanced. The simultaneous development of minimally invasive catheter techniques in children, led to the concept of treating the foetal heart directly, in an attempt to prevent the changes which had been observed. Early efforts at prenatal valvuloplasty were largely set aside after poor results and the coincidental development of alternative, increasingly successful, postnatal surgical strategies...
May 2012: Early Human Development
Stephen P Emery, Jacqueline Kreutzer, Frances M McCaffrey, Fredrick S Sherman, Hyagriv N Simhan, Bradley B Keller
Objectives. Multiple technical difficulties are encountered when a multidisciplinary team of subspecialists begins a minimally-invasive fetal cardiac interventional program. We describe the learning curve. Study Design. Ten pregnant sheep underwent ultrasound-guided balloon valvuloplasty of the aortic valve. Team members and their roles remained constant through the trial. The time between needle insertion and entrance of the left ventricle at the aortic root was recorded. F-test was used to assess significance (P ≤ ...
2010: Minimally Invasive Surgery
Joanna Dangel, Marzena Debska, Adam Koleśnik, Marek Dabrowski, Piotr Kretowicz, Romuald Debski, Anna Brudkowska
Prenatal aortic valvuloplasty is performed only in few perinatal centers in the world. Critical aortic stenosis which can lead to hypoplastic left heart syndrome or severe fetal heart failure with nonimmune hydrops is an indication for this procedure. Prenatal intervention can change the natural course of the disease. Authors present the first successful fetal balloon aortic valvuloplasty in Poland. It was performed in a 29-week fetus with critical aortic stenosis, severe impairment of left ventricular function, heart failure and fetal hydrops...
August 2011: Ginekologia Polska
Bryan H Goldstein, Carlen G Fifer, Aimee K Armstrong, Sarah K Gelehrter, Marjorie C Treadwell, Cosmas van de Ven, Albert P Rocchini
Fetal cardiac intervention for critical aortic stenosis (AS) with evolving hypoplastic left heart syndrome is performed in an attempt to maintain a biventricular circulation postnatally. The procedure has been hindered by technical challenges and poor candidate selection. We report here the novel use of a pressure guidewire during aortic valvuloplasty in a fetus at 21 weeks' gestation with critical AS and evolving hypoplastic left heart syndrome. Use of a pressure guidewire during fetal cardiac intervention offers several potential advantages over existing protocols...
September 2011: Pediatrics
Lindsay S Rogers, Amy L Peterson, J William Gaynor, Jonathan J Rome, Paul M Weinberg, Jack Rychik
BACKGROUND: Mitral valve dysplasia syndrome is a unique form of left-sided heart disease characterized by aortic outflow hypoplasia, dilated left ventricle, dysplastic/incompetent mitral valve, and a restrictive/intact atrial septum. Patients with this constellation of abnormalities have been managed in a variety of ways with overall poor outcomes. METHODS: We performed a retrospective review of all patients with mitral valve dysplasia syndrome to identify fetal echocardiographic markers predictive of outcomes...
December 2011: Journal of Thoracic and Cardiovascular Surgery
Kevin G Friedman, Renee Margossian, Dionne A Graham, David M Harrild, Sitaram M Emani, Louise E Wilkins-Haug, Doff B McElhinney, Wayne Tworetzky
Fetal aortic balloon valvuloplasty (FAV) has shown promise in altering in utero progression of aortic stenosis to hypoplastic left heart syndrome. In patients who achieve a biventricular circulation after FAV, left ventricular (LV) compliance may be impaired. Echocardiographic indexes of diastolic function were compared between patients with biventricular circulation after FAV, congenital aortic stenosis (AS), and age-matched controls. In the neonatal period, patients with FAV had similar LV, aortic, and mitral valve dimensions but more evidence of endocardial fibroelastosis than patients with AS...
August 15, 2011: American Journal of Cardiology
Yimin Hua, Sen Yang, Kaiyu Zhou, Nan Guo, Qi Zhu, Rong Zhou, Dezhi Mu, Xiaoqin Jiang
OBJECTIVE: Intrauterine balloon aortic valvuloplasty (IUBAV) has been used to correct critical aortic valve stenosis. Evaluation of the intervention-related risk is necessary. The purpose of this study was to establish an experimental goat model for ultrasound-guided IUBAV intervention and investigate the immediate and long-term effects of IUBAV on the fetus, gestational outcome and mother's safety. STUDY DESIGN: Fifteen pregnant goats with twin gestation in the 2nd and 3rd trimester were anesthetized to establish the surgical procedure...
2011: Fetal Diagnosis and Therapy
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