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https://www.readbyqxmd.com/read/27902356/luciferase-tagged-wild-type-and-tropism-deficient-mouse-cytomegaloviruses-reveal-early-dynamics-of-host-colonization-following-peripheral-challenge
#1
Helen Farrell, Martha Oliveira, Kate Macdonald, Joseph Yunis, Michael Mach, Kimberley Bruce, Philip Stevenson, Rhonda Cardin, Nicholas Davis-Poynter
Cytomegaloviruses (CMVs) establish persistent, systemic infections and cause disease by maternal-fetal transfer, suggesting that their dissemination is a key target for anti-viral intervention. Late clinical presentation has meant that human CMV dissemination is not well understood. Murine CMV provides a tractable model. Whole mouse imaging of virus-expressed luciferase has proved a useful way to track systemic infections. MCMV, in which the abundant lytic gene M78 was luciferase tagged via a self-cleaving peptide (M78-LUC), allowed serial, unbiased imaging of systemic and peripheral infection without significant virus attenuation...
October 26, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27900852/association-of-ultrasound-based-measures-of-fetal-body-composition-with-newborn-adiposity
#2
S Ikenoue, F Waffarn, K Sumiyoshi, M Ohashi, C Ikenoue, C Buss, D L Gillen, H N Simhan, S Entringer, P D Wadhwa
BACKGROUND: Newborns exhibit substantial variation in gestational age-adjusted and sex-adjusted fat mass proportion. The antecedent characteristics of fetal body composition that are associated with newborn fat mass proportion are poorly understood. OBJECTIVE: The aim of this study was to determine whether a composite measure of fetal fat mass is prospectively associated with newborn adiposity. METHODS: In a longitudinal study of 109 low-risk pregnancies, fetal ultrasonography was performed at approximately 12, 20 and 30 weeks gestation...
November 29, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27899082/interventions-to-improve-gross-motor-performance-in-children-with-neurodevelopmental-disorders-a-meta-analysis
#3
Barbara R Lucas, Elizabeth J Elliott, Sarah Coggan, Rafael Z Pinto, Tracy Jirikowic, Sarah Westcott McCoy, Jane Latimer
BACKGROUND: Gross motor skills are fundamental to childhood development. The effectiveness of current physical therapy options for children with mild to moderate gross motor disorders is unknown. The aim of this study was to systematically review the literature to investigate the effectiveness of conservative interventions to improve gross motor performance in children with a range of neurodevelopmental disorders. METHODS: A systematic review with meta-analysis was conducted...
November 29, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27898024/perinatal-arterial-ischemic-stroke-is-associated-to-materno-fetal-immune-activation-and-intracranial-arteritis
#4
Clémence Guiraut, Nicole Cauchon, Martin Lepage, Guillaume Sébire
The medium-size intra-cranial arteries arising from the carotid bifurcation are prone to perinatal arterial ischemic strokes (PAIS). PAIS' physiopathology needs to be better understood to develop preventive and therapeutic interventions that are currently missing. We hypothesized that materno-fetal inflammation leads to a vasculitis affecting selectively the carotidian tree and promoting a focal thrombosis and subsequent stroke. Dams were injected with saline or lipopolysaccharide (LPS) from Escherichia coli...
November 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27897026/-acute-myocardial-infarction-complicated-pregnancy-of-patient-after-kindey-transplantation-and-knee-osteosarcoma
#5
K Lehnertová, K Huml, R Pilka
OBJECTIVE: Case report describes a patient with acute ST elevation myocardial infarction with Q wave in 26 weeks gestation. DESIGN: Case report. SETTING: Department of Obstetrics and Gynecology, University Hospital, Palacky University, Olomouc. CASE REPORT: Medical history is complicated with a cadaveric transplantation of kindey, osteosarcoma of the left knee with a joint extraction and chemotherapy, serious hypothyreosis after spontaneous discontinuation of medication and missing fetal nasal bone at the ultrasound examination...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27893064/effect-of-increased-enteral-protein-intake-on-growth-in-human-milk-fed-preterm-infants-a-randomized-clinical-trial
#6
Christoph Maas, Michaela Mathes, Christine Bleeker, Julia Vek, Wolfgang Bernhard, Cornelia Wiechers, Andreas Peter, Christian F Poets, Axel R Franz
Importance: Protein, supplied in currently available commercial fortifiers, may be inadequate to meet the requirements of very preterm infants; in addition, intraindividual and interindividual variability of human milk protein and energy content potentially contribute to unsatisfactory early postnatal growth. Objective: To determine effects on growth of different levels of enteral protein supplementation in predominantly human milk-fed preterm infants. Design, Setting, and Participants: This randomized clinical and partially blinded single-center trial was conducted in a neonatal tertiary referral center in Germany...
November 21, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27891300/fetal-alcohol-spectrum-disorders-fasd-an-approach-to-effective-prevention
#7
REVIEW
Sylvia Roozen, D Black, G-J Y Peters, G Kok, D Townend, J G Nijhuis, G H Koek, L M G Curfs
PURPOSE OF REVIEW: The objective of the current contribution is to propose an evidence-based, six-step approach to develop effective programs for prevention of fetal alcohol spectrum disorders. RECENT FINDINGS: Despite widespread campaigns aimed to reduce prenatal alcohol exposure, the number of affected children continues to be high. Current strategies to reduce prenatal alcohol exposure may be ineffective or counterproductive. However, proven principles of health promotion could be applied to reduce drinking in pregnancy...
2016: Current Developmental Disorders Reports
https://www.readbyqxmd.com/read/27889063/andr%C3%A3-e-gruslin-award-lecture-metabolomics-as-an-important-modality-to-better-understand-preeclampsia
#8
S J Benton, C Ly, S Vukovic, S A Bainbridge
Preeclampsia (PE) is a complex disorder that affects 3-5% of all pregnancies and is a leading cause of maternal and fetal morbidity and mortality. To date, the heterogeneity of clinical presentation, disease severity and outcomes have limited significant advances in early prediction, diagnosis, and therapeutic intervention of PE. The rapidly expanding field of metabolomics, which has the capacity to quantitatively detect low molecular weight compounds (metabolites) in tissue and biological fluids, shows tremendous promise in gaining a better understanding of PE...
November 16, 2016: Placenta
https://www.readbyqxmd.com/read/27888221/severe-endocarditis-and-open-heart-surgery-during-pregnancy
#9
Arnoud W Kastelein, Nanne Y Oldenburger, Mariëlle G van Pampus, Erica W M Janszen
A woman aged 36 years G2P1 presented at our outpatient clinic with symptoms of discomfort, dyspnoea and fever at a gestational age of 17 weeks. She was subsequently diagnosed with severe endocarditis with a large vegetation on the mitral valve. She underwent open chest mitral valve surgery while on cardiopulmonary bypass (CPB) within a few days. Such surgical intervention is not only associated with increased maternal risks, but also with severe fetal morbidity and mortality. In such patients, certain perioperative measures can diminish these risks...
November 25, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27887753/effect-of-culturally-competent-educational-films-about-prenatal-screening-on-informed-decision-making-of-pregnant-women-in-the-netherlands
#10
I A Peters, A G Posthumus, J C I Y Reijerink-Verheij, H M E Van Agt, M F C M Knapen, S Denktaş
OBJECTIVE: To evaluate the effect of a culturally competent educational film (CCEF) on informed decision making (IDM) regarding prenatal screening (PS) in a study population consisting of multicultural pregnant women. METHODS: A cross-sectional study with 262 women in the control group and 117 in the intervention group. All counselled participants received a self-report questionnaire to obtain data on IDM and only the intervention group received the CCEF. Twenty two percent of the study population had an ethnic minority background and 52% had a low or medium educational level...
November 15, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/27887710/supplementation-with-progestogens-in-the-first-trimester-of-pregnancy-to-prevent-miscarriage-in-women-with-unexplained-recurrent-miscarriage-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
Gabriele Saccone, Corina Schoen, Jason M Franasiak, Richard T Scott, Vincenzo Berghella
OBJECTIVE: To investigate whether treatment with progestogens in the first trimester of pregnancy would decrease the incidence of miscarriage in women with a history of unexplained recurrent miscarriage. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Women with a history of unexplained recurrent miscarriage. INTERVENTION(S): Randomized, controlled trials were identified by searching electronic databases...
November 22, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27886948/variation-in-hospital-intrapartum-practices-and-association-with-cesarean-rate
#12
Lisbet S Lundsberg, Jessica L Illuzzi, Aileen M Gariepy, Sangini S Sheth, Christian M Pettker, Henry C Lee, Heather S Lipkind, Xiao Xu
OBJECTIVE: To examine hospital variation in intrapartum care and its relationship with cesarean rates. DESIGN: Cross-sectional survey. SETTING: Connecticut and Massachusetts hospitals providing obstetric services. PARTICIPANTS: Nurse managers or other clinical staff knowledgeable about intrapartum care. METHODS: We assessed labor and birth unit capacity and staffing, fetal monitoring, labor management, intrapartum interventions, newborn care, quality assurance, and performance review practices...
November 22, 2016: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/27886341/clinical-efficacy-of-therapeutic-intervention-for-subclinical-hypothyroidism-during-pregnancy
#13
R Ju, L Lin, Y Long, J Zhang, J Huang
This study explored the effects of levothyroxine (L-T4) replacement therapy on pregnancy outcomes in patients with subclinical hypothyroidism (SCH). We analyzed the effects on pregnancy outcomes with respect to gestational week when the desired thyroid-stimulating hormone (TSH) level was reached as well as the length of time required to reach the target level during L-T4 treatment. This study enrolled 457 patients diagnosed with SCH upon initial thyroid function screening. Subjects were assigned to the treatment group (N = 184), and the control group (N = 273)...
November 21, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27884654/a-narrative-review-of-interventions-addressing-the-parental-fetal-relationship
#14
Nicole Borg Cunen, Julie Jomeen, Rita Borg Xuereb, Angela Poat
BACKGROUND: Expectant parents develop varying degrees of emotional affiliation with the unborn child. Interventions supporting this relationship may be beneficial given its link to maternal health behaviour during pregnancy, as well as the parental-infant bond after birth. AIM: To identify and describe the effects of programmes and strategies that have addressed the parental-fetal relationship. METHOD: English-language primary studies, published between 2005-2015, were identified and their methodological quality was assessed...
November 21, 2016: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/27875671/immune-mediated-brain-pathology-from-autoantibodies-to-microglia
#15
Jacquelyn Nestor, Adriana Gata-Garcia, Yoshiyuki Arinuma, Yuichiro Fujieda, Czeslawa Kowal, Betty Diamond
Cells and molecules of the immune system contribute to brain pathology as well as to brain homeostasis. We suggest that there are numerous anti-brain antibodies that can cause acute neuronal dysfunction if they penetrate brain parenchyma. Many of these acute immune-mediated insults may alter the homeostatic mechanisms in the brain and initiate pathologic events that no longer depend on the presence of the inciting antibody, but rather on microglial cell activation. This paradigm, if correct, suggests that there may be two potential moments of therapeutic intervention...
October 2016: Discovery Medicine
https://www.readbyqxmd.com/read/27871268/metformin-and-dietary-advice-to-improve-insulin-sensitivity-and-promote-gestational-restriction-of-weight-among-pregnant-women-who-are-overweight-or-obese-the-grow-randomised-trial
#16
Jodie M Dodd, Rosalie M Grivell, Andrea R Deussen, Gustaaf Dekker, Jennie Louise, William Hague
BACKGROUND: Obesity is a significant global health problem, with approximately 50% of women entering pregnancy having a body mass index greater than or equal to 25 kg/m(2). Obesity during pregnancy is associated with a well-recognised increased risk of adverse health outcomes both for the woman and her infant. Currently available data from large scale randomised trials and systematic reviews highlight only modest effects of antenatal dietary and lifestyle interventions in limiting gestational weight gain, with little impact on clinically relevant pregnancy outcomes...
November 21, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27867946/advances-in-fetal-surgery
#17
REVIEW
Kathryn M Maselli, Andrea Badillo
Historically, the gold standard for the treatment of congenital malformations has been planned delivery at tertiary care center with attempted post-natal repair or amelioration of the lesion. Over the last few decades however, rapid advances in imaging and instrumentation technology combined with superior knowledge of fetal pathophysiology has led to the development of novel intrauterine interventions for most common fetal anomalies. Great success has already been seen the treatment of previous devastating anomalies such as myelomeningocele (MMC), congenital cystic malformations of the lung, twin-twin transfusion, and sacrococcygeal teratomas...
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27867682/treatment-of-pregnant-women-with-a-diagnosis-of-inflammatory-bowel-disease
#18
REVIEW
Sule Poturoglu, Asli Ciftcibasi Ormeci, Ali Erkan Duman
The frequency of diagnosis of inflammatory bowel disease (IBD) has increased in younger populations. For this reason, pregnancy in patients with IBD is a topic of interest, warranting additional focus on disease management during this period. The main objective of this article is to summarize the latest findings and guidelines on the management of potential problems from pregnancy to the breastfeeding stage. Fertility is decreased in patients with active IBD. Disease remission prior to conception will likely decrease the rate of pregnancy-related complications...
November 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27865988/persistent-and-new-onset-daytime-sleepiness-in-pregnant-women-a-prospective-observational-cohort-study
#19
Shao-Yu Tsai, Pei-Lin Lee, Jou-Wei Lin, Chien-Nan Lee
BACKGROUND: Daytime sleepiness is a frequent complaint in women during pregnancy. It has also been linked to negative obstetric consequences. Although high prevalence of excessive daytime sleepiness throughout pregnancy is well-documented, neither the causes of persistent daytime sleepiness nor new-onset daytime sleepiness during pregnancy have been investigated. Identifying predictive factors may play an important role in the management of daytime sleepiness in pregnant women and improve prenatal care and maternal-fetal outcomes...
November 8, 2016: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/27865941/local-injection-of-diluted-vasopressin-followed-by-suction-curettage-for-cervical-ectopic-pregnancy
#20
Hiroshi Ishikawa, Youichi Unno, Akiko Omoto, Makio Shozu
OBJECTIVE: To report the results of local injection of diluted vasopressin followed by suction curettage as a conservative treatment for women with cervical ectopic pregnancy, who wish to preserve their future fertility. STUDY DESIGN: This was a retrospective chart review in a university hospital and a municipal hospital. We injected diluted vasopressin (Pitressin R, total amount of 4-10 units) transvaginally into the cervix surrounding the gestational sac, but not directly into the gestational sac, and/or the lower segment of the uterine body under transvaginal ultrasonographic guidance...
November 11, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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