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Fetal intervention

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https://www.readbyqxmd.com/read/29928762/effect-of-choline-supplementation-on-neurological-cognitive-and-behavioral-outcomes-in-offspring-arising-from-alcohol-exposure-during-development-a-quantitative-systematic-review-of-clinical-and-preclinical-studies
#1
Lisa K Akison, Jenny Kuo, Natasha Reid, Roslyn N Boyd, Karen M Moritz
Prenatal alcohol exposure results in cognitive, behavioral and neurological deficits in offspring. There is an urgent need for safe and effective treatments to overcome these effects. Maternal choline supplementation has been identified as a potential intervention. Our objective was to review preclinical and clinical studies using choline supplementation in known cases of fetal alcohol exposure to determine its effectiveness in ameliorating deficits in offspring. A systematic search of six electronic databases was conducted and studies selected by reviewing titles/abstracts against specific inclusion/exclusion criteria...
June 21, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29925843/intraamniotic-zika-virus-inoculation-of-pregnant-rhesus-macaques-produces-fetal-neurologic-disease
#2
Lark L Coffey, Rebekah I Keesler, Patricia A Pesavento, Kevin Woolard, Anil Singapuri, Jennifer Watanabe, Christina Cruzen, Kari L Christe, Jodie Usachenko, JoAnn Yee, Victoria A Heng, Eliza Bliss-Moreau, J Rachel Reader, Wilhelm von Morgenland, Anne M Gibbons, Kenneth Jackson, Amir Ardeshir, Holly Heimsath, Sallie Permar, Paranthaman Senthamaraikannan, Pietro Presicce, Suhas G Kallapur, Jeffrey M Linnen, Kui Gao, Robert Orr, Tracy MacGill, Michelle McClure, Richard McFarland, John H Morrison, Koen K A Van Rompay
Zika virus (ZIKV) infection of pregnant women can cause fetal microcephaly and other neurologic defects. We describe the development of a non-human primate model to better understand fetal pathogenesis. To reliably induce fetal infection at defined times, four pregnant rhesus macaques are inoculated intravenously and intraamniotically with ZIKV at gestational day (GD) 41, 50, 64, or 90, corresponding to first and second trimester of gestation. The GD41-inoculated animal, experiencing fetal death 7 days later, has high virus levels in fetal and placental tissues, implicating ZIKV as cause of death...
June 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29921302/effectiveness-of-pregnant-women-s-active-participation-in-their-antenatal-care-for-the-control-of-malaria-and-anaemia-in-pregnancy-in-ghana-a-cluster-randomized-controlled-trial
#3
Gifty Dufie Ampofo, Harry Tagbor, Imelda Bates
BACKGROUND: The burden of malaria and anaemia in pregnancy remains high despite the availability of proven efficacious antenatal care interventions. Sub-optimal uptake of the interventions may be due to inadequate active participation of pregnant women in their antenatal care. It was hypothesized that providing opportunities for pregnant women to improve upon active participation in their antenatal care through malaria and anaemia point-of-care testing would improve adherence to ANC recommendations and interventions and lead to better pregnancy outcomes...
June 19, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29915741/factors-influencing-the-place-of-delivery-in-rural-meghalaya-india-a-qualitative-study
#4
Amrita Sarkar, Ophelia Mary Kharmujai, Wallambok Lynrah, Neilatuo U Suokhrie
Background: In Meghalaya, only 51.4% expectant mothers go for any institutional delivery with a wide rural-urban gap causing morbidity and mortality in the mothers and the neonates. Objectives: The objective of this study is to find out the factors influencing the choice of the place of delivery in rural women. Methodology: The present qualitative cross-sectional study was conducted from October to December 2016 in Bhoirymbong community health center (CHC) and the area catered to by it...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29914395/factors-promoting-or-inhibiting-normal-birth
#5
Samantha J Prosser, Adrian G Barnett, Yvette D Miller
BACKGROUND: In response to rising rates of medical intervention in birth, there has been increased international interest in promoting normal birth (without induction of labour, epidural/spinal/general anaesthesia, episiotomy, forceps/vacuum, or caesarean section). However, there is limited evidence for how best to achieve increased rates of normal birth. In this study we examined the role of modifiable and non-modifiable factors in experiencing a normal birth using retrospective, self-reported data...
June 18, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29914277/the-fetal-fibronectin-test-25-years-after-its-development-what-is-the-evidence-regarding-its-clinical-utility-a-systematic-review-and-meta-analysis
#6
Gilles Faron, Lisa Balepa, José Parra, Jean-François Fils, Leonardo Gucciardo
BACKGROUND: The identification of women at risk for preterm birth should allow interventions which could improve neonatal outcome. Fetal fibronectin, a glycoprotein which acts normally as glue between decidua and amniotic membranes could be a good marker of impending labour when its concentration in cervicovaginal secretions between 22 and 36 weeks of gestation is ≥ 50 ng/mL. Many authors worldwide have tested this marker with many different methodologies and clinical settings, but conclusions about its clinical use are mixed...
June 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29909749/a-comparison-of-maternal-and-neonatal-outcomes-with-forceps-delivery-versus-cesarean-delivery
#7
Xiaohua Liu, Mark B Landon, Weiwei Cheng, Yan Chen
OBJECTIVE: To compare maternal and neonatal outcomes by forceps vaginal delivery versus cesarean delivery during the second stage of labor. METHODS: We conducted a retrospective cohort study in a large tertiary maternity center in Shanghai, China through 2007-2016. A total of 7046 women carrying a singleton term nonanomalous fetus with vertex presentation who underwent forceps vaginal delivery, or cesarean delivery from a low station in the second stage of labor were included...
June 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29908431/smoking-ban-and-health-at-birth-evidence-from-hungary
#8
Tamás Hajdu, Gábor Hajdu
In 2012, smoking restrictions were extended to hospitality venues in Hungary. Women working in bars and restaurants were primarily affected by the intervention. In this research, we analyze the effect of this smoking ban on the outcomes of their pregnancies. Using individual live birth, fetal loss, and infant mortality registry data, we examine the probability of live birth, indicators of health at birth, and the probability of death in the first year of life. We apply a difference-in-differences framework and show that the smoking ban has improved health at birth...
June 13, 2018: Economics and Human Biology
https://www.readbyqxmd.com/read/29905020/persistent-fetal-cardiovascular-remodeling-in-art-children
#9
Medhat Alberry
Children conceived by ART have manifested cardiac and vascular remodeling. There is growing evidence that remodeling is present in fetal life and persists in postnatal life which suggest the presence of opportunities for early detection and potential intervention. The underlying mechanisms and the effect of potential confounders such as growth restriction or prematurity remain unclear. Scherrer U, et al, Eur Heart J. 2015 Jul 1;36(25):1583-9. This article is protected by copyright. All rights reserved.
June 15, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29901641/spontaneous-postnatal-complete-resolution-of-an-antenatally-diagnosed-fetal-hepatic-cyst-a-case-report
#10
Denis Mihai Serban, Costela Serban, Dan Navolan, Ioan Sas
RATIONALE: Antenatal diagnosis of a fetal hepatic cyst is rare. Since in most cases the lesion is treated after birth by surgery only a few reports present a complete spontaneous resolution of an antenatally diagnosed hepatic cyst. PATIENT CONCERNS: A single hepatic cyst (1.34/1.47 cm) was diagnosed in a fetus at 36 weeks of pregnancy while mother was in labor. After an uneventful vaginal birth, a multidisciplinary evaluation of the newborn confirmed the presence of the cyst...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901247/joint-contracture-is-reduced-by-intra-articular-implantation-of-rosiglitazone-loaded-hydrogels-in-a-rabbit-model-of-arthrofibrosis
#11
Diren Arsoy, Christopher G Salib, William H Trousdale, Meagan E Tibbo, Afton K Limberg, Anthony Viste, Eric A Lewallen, Nicolas Reina, Michael J Yaszemski, Daniel J Berry, Andre J van Wijnen, Mark E Morrey, Joaquin Sanchez-Sotelo, Matthew P Abdel
Trauma, surgery, and other inflammatory conditions can lead to debilitating joint contractures. Adjunct pharmacologic modalities may permit clinical prevention and treatment of recalcitrant joint contractures. We investigated the therapeutic potential of rosiglitazone by intra-articular delivery via oligo[poly(ethylene glycol)fumarate] (OPF) hydrogels in an established rabbit model of arthrofibrosis. OPF hydrogels loaded with rosiglitazone were characterized for drug elution properties upon soaking in minimum essential media (MEM) with 10% fetal bovine serum and measurements of drug concentrations via High Performance Liquid Chromatography (HPLC)...
June 14, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29900608/early-labor-cerebroplacental-ratio-assessment-in-uncomplicated-term-pregnancies-and-prediction-of-adverse-perinatal-outcomes-a-prospective-multicentre-study
#12
Andrea Dall'Asta, Tullio Ghi, Giuseppe Rizzo, Annalisa Cancemi, Filomena Aloisio, Domenico Arduini, Giuseppe Pedrazzi, Francesc Figueras, Tiziana Frusca
INTRODUCTION: Doppler ultrasound has recently been suggested to identify subclinical placental functional impairment among normal sized term fetuses. The objective of this study was to evaluate the relationship between cerebroplacental ratio (CPR) measured in early labor and perinatal and delivery outcomes in a cohort of uncomplicated singleton term pregnancies. METHODS: This was a multicentre, prospective, observational study involving three Tertiary Centres. Low risk term pregnancies, as defined by the absence of any maternal morbidity and pregnancy complication and normal ultrasound and clinical screening of the fetal growth in the third trimester, with spontaneous onset of labor were included...
June 13, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29900544/intervention-thresholds-and-cesarean-section-rates-a-time-trends-analysis
#13
Anna Rose, Edwin Amalraj Raja, Sohinee Bhattacharya, Mairead Black
INTRODUCTION: In order to improve understanding of rising cesarean section (CS) rates in the UK, this study assessed the relation between clinician thresholds for performing CS for delayed labor progress or suspected fetal distress and corresponding CS rates in Aberdeen, UK. MATERIAL AND METHODS: Time-trends analysis of term births from 1988 to 2012 in a population of nulliparous women (n=53 745) in Aberdeen, UK using Chi-square test for trend, and binary logistic regression...
June 14, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29900526/transplacental-versus-direct-fetal-corticosteroid-treatment-for-accelerating-fetal-lung-maturation-where-there-is-a-risk-of-preterm-birth
#14
REVIEW
Debby P Utama, Caroline A Crowther
BACKGROUND: Despite major advances in medical technology, the incidence of preterm birth remains high. The use of antenatal corticosteroid administered transplacentally, by intramuscular injection to women at risk of preterm birth, has reduced the incidence of respiratory distress syndrome and increased the survival rates of preterm infants. However, this intervention also comes with its own risks and side effects. Animal studies and early studies in pregnant women at risk of preterm birth have reported the use of an alternative route of administration, by direct intramuscular injection of corticosteroid into the fetus under ultrasound guidance, in an attempt to minimise the side-effect profile...
June 14, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29895996/maternal-and-early-perinatal-outcomes-of-triplet-pregnancy-study-of-82-triplets-from-a-single-perinatal-centre-in-south-india
#15
Priya Rajan, Srinivas Murki, Suseela Vavilala, Nirupama Surubhotla
Objectives: To study the recent trends in maternal and perinatal outcomes of triplet pregnancy from a perinatal centre in South India. Methods: All triplet pregnancies booked at Fernandez hospital, Hyderabad (a tertiary care perinatal centre in South India), or those referred between 2000 and 2014 were included in the study. The maternal, fetal and neonatal outcome and any interventions like cerclage, steroid administration were studied. Results: There were 82 triplet deliveries over the study period of 15 years (82 per 69,584 live births)...
June 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29895839/robust-increases-in-erythropoietin-production-by-the-hypoxic-fetus-is-a-response-to-protect-the-brain-and-other-vital-organs
#16
REVIEW
Kari A Teramo, Miira M Klemetti, John A Widness
Fetal erythropoietin (EPO), in addition to regulating erythropoiesis, has also tissue-protective properties based on its anti-inflammatory, anti-apoptotic, antioxidant, and neurotrophic effects. Notably, EPO concentrations needed for tissue protection are 100-1000 times higher than concentrations needed for regulating erythropoiesis. This dual effect of EPO is based on EPO-receptor (EPO-R) isoforms, which differ structurally and functionally. We hypothesize in this Integrated Mechanism Review that during severe fetal hypoxia the observed, but poorly understood, marked increases of fetal plasma EPO concentrations occur to protect the brain, heart, and other vital fetal organs...
June 12, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29895718/impact-of-prematurity-for-pancreatic-islet-and-beta-cell-development
#17
Frank H Bloomfield
As increasing numbers of babies born preterm survive into adulthood, it is becoming clear that, in addition to the well-described risks of neurodevelopmental sequelae, there also are increased risks for non-communicable diseases, including diabetes. Epidemiological studies indicate that risks are increased even for birth at late preterm and early term gestations and for both type 1 and type 2 diabetes. Thus, factors related to preterm birth likely affect development of the fetal and neonatal beta-cell in addition to effects on peripheral insulin sensitivity...
June 12, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29895077/a-standardized-approach-for-category-ii-fetal-heart-rate-with-significant-decelerations-maternal-and-neonatal-outcomes
#18
Laurence E Shields, Suzanne Wiesner, Catherine Klein, Barbara Pelletreau, Herman L Hedriana
OBJECTIVE:  To determine if a standardized intervention process for Category II fetal heart rates (FHRs) with significant decels (SigDecels) would improve neonatal outcome and to determine the impact on mode of delivery rates. STUDY DESIGN:  Patients with Category II FHRs from six hospitals were prospectively managed using a standardized approach based on the presence of recurrent SigDecels. Maternal and neonatal outcomes were compared between pre- (6 months) and post-(11 months) implementation...
June 12, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29894897/prognostic-model-based-on-image-based-time-frequency-features-and-genetic-algorithm-for-fetal-hypoxia-assessment
#19
Zafer Cömert, Adnan Fatih Kocamaz, Velappan Subha
Cardiotocography (CTG) is applied routinely for fetal monitoring during the perinatal period to decrease the rates of neonatal mortality and morbidity as well as unnecessary interventions. The analysis of CTG traces has become an indispensable part of present clinical practices; however, it also has serious drawbacks, such as poor specificity and variability in its interpretation. The automated CTG analysis is seen as the most promising way to overcome these disadvantages. In this study, a novel prognostic model is proposed for predicting fetal hypoxia from CTG traces based on an innovative approach called image-based time-frequency (IBTF) analysis comprised of a combination of short time Fourier transform (STFT) and gray level co-occurrence matrix (GLCM)...
June 6, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29892052/review-and-gap-analysis-molecular-pathways-leading-to-fetal-alcohol-spectrum-disorders
#20
Friederike Ehrhart, Sylvia Roozen, Jef Verbeek, Ger Koek, Gerjo Kok, Henk van Kranen, Chris T Evelo, Leopold M G Curfs
Alcohol exposure during pregnancy affects the development of the fetus in various ways and may lead to Fetal Alcohol Spectrum Disorders (FASD). FASD is one of the leading preventable forms of neurodevelopmental disorders. In the light of prevention and early intervention, knowledge on how ethanol exposure induces fetal damage is urgently needed. Besides direct ethanol and acetaldehyde toxicity, alcohol increases oxidative stress, and subsequent general effects (e.g., epigenetic imprinting, gene expression, and metabolite levels)...
June 11, 2018: Molecular Psychiatry
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