Vikash Jaiswal, Vibhor Agrawal, Yashita Khulbe, Muhammad Hanif, Helen Huang, Maha Hameed, Abhigan Babu Shrestha, Francesco Perone, Charmy Parikh, Sabas Ivan Gomez, Kusum Paudel, Jerome Zacks, Kendra J Grubb, Salvatore De Rosa, Alessia Gimelli
Cardiac amyloidosis is caused by the extracellular deposition of amyloid fibrils in the heart, involving not only the myocardium but also any cardiovascular structure. Indeed, this progressive infiltrative disease also involves the cardiac valves and, specifically, shows a high prevalence with aortic stenosis. Misfolded protein infiltration in the aortic valve leads to tissue damage resulting in the onset or worsening of valve stenosis. Transthyretin cardiac amyloidosis and aortic stenosis coexist in patients > 65 years in about 4-16% of cases, especially in those undergoing transcatheter aortic valve replacement...
November 2023: Eur Heart J Open