Ningjing Qian, Yaping Wang, Wangxing Hu, Naifang Cao, Yi Qian, Jinyong Chen, Juan Fang, Dilin Xu, Haochang Hu, Shuangshuang Yang, Dao Zhou, Hanyi Dai, Dongdong Wei, Jian'an Wang, Xianbao Liu
BACKGROUND: Calcific aortic valve stenosis (CAVS) is one of the most challenging heart diseases in clinical with rapidly increasing prevalence. However, study of the mechanism and treatment of CAVS is hampered by the lack of suitable, robust and efficient models that develop hemodynamically significant stenosis and typical calcium deposition. Here, we aim to establish a mouse model to mimic the development and features of CAVS. METHODS: The model was established via aortic valve wire injury (AVWI) combined with vitamin D subcutaneous injected in wild type C57/BL6 mice...
February 19, 2024: Animal Models and Experimental Medicine