Manuela Rizzi, Vincenzo Avellis, Alessandro Messina, Chiara Germano, Elena Tavella, Valentina Dodaro, Raffaele Vitale, Alberto Revelli, Paolo Zola, Simonetta Picone, Pier Michele Paolillo, Vito Mondì, Bianca Masturzo, Paolo Manzoni, Pier Paolo Sainaghi
To date, the SARS-CoV-2 pandemic still represents a great clinical challenge worldwide, and effective anti-COVID-19 drugs are limited. For this reason, nutritional supplements have been investigated as adjuvant therapeutic approaches in disease management. Among such supplements, vitamin D has gained great interest, due to its immunomodulatory and anti-inflammatory actions both in adult and pediatric populations. Even if there is conflicting evidence about its prevention and/or mitigation effectiveness in SARS-CoV-2 infection, several studies demonstrated a strict correlation between hypovitaminosis D and disease severity in acute COVID-19 and MIS-C (multisystem inflammatory syndrome in children)...
March 27, 2024: International Journal of Molecular Sciences