keyword
https://read.qxmd.com/read/38536958/assessing-the-interaction-effects-of-mitochondrial-dna-polymorphisms-and-lifestyle-on-heel-bone-mineral-density
#1
JOURNAL ARTICLE
Dan He, Huan Liu, Yijing Zhao, Wenming Wei, Qingqing Cai, Sirong Shi, Xiaoge Chu, Na Zhang, Xiaoyue Qin, Yumeng Jia, Yan Wen, Bolun Cheng, Feng Zhang
BACKGROUND: Bone mineral density (BMD) is a major predictor of osteoporotic fractures, and previous studies have reported the effects of mitochondrial dysfunction and lifestyle on BMD, respectively. However, their interaction effects on BMD are still unclear. Therefore, we aimed to investigate the possible interaction of mitochondrial DNA (mtDNA) and common lifestyles contributing to osteoporosis. METHODS: Our analysis included 119,120 white participants (Nfemale=65,949 and Nmale=53,171) from the UK Biobank with heel BMD phenotype data...
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38535844/effect-of-simultaneous-dietary-supplementation-of-betaine-selenomethionine-and-vitamins-e-and-c-under-summer-conditions-in-growing-finishing-pigs
#2
JOURNAL ARTICLE
Lotte De Prekel, Dominiek Maes, Alice Van den Broeke, Bart Ampe, Marijke Aluwé
Heat stress in pigs negatively affects welfare, health, and performance. Osmoprotectants and antioxidants may alleviate oxidative damage during hot periods. We investigated whether an additive-enriched feed can reduce negative effects in pigs during summer conditions. Sixty growing-finishing pigs were allocated into two groups: the control (CF) and summer feed (SF) group. The CF group contained 0.4 mg/kg inorganic selenium and 100 ppm vitamin E, while the SF group contained 0.3 mg/kg inorganic selenium, 0.1 mg/kg selenomethionine, 200 ppm vitamins E and C, and 0...
March 1, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535664/enhanced-stability-of-oral-vitamin-c-delivery-a-novel-large-scale-method-for-liposomes-production-and-encapsulation-through-dynamic-high-pressure-microfluidization
#3
JOURNAL ARTICLE
Eugenia Romano, Roberta Palladino, Mariagabriella Cannavale, Erwin Pavel Lamparelli, Barbara Maglione
In recent years, nanocarriers have been widely used as an effective solution for oral administration of pharmaceuticals. However, there is still an urgent need to speed up their translation to clinical practice. Cost-effective and industrially scalable methodologies are still needed. Herein, the production of vitamin C-loaded liposomes for nutraceutical purposes has been investigated and optimized by adopting a High-Pressure Homogenizer. Initially, the impact of process parameters on particles size, distributions, and morphology was explored...
March 14, 2024: Nanomaterials
https://read.qxmd.com/read/38534743/effects-of-letrozole-treatment-and-vitamin-c-supplementation-on-morphology-endoplasmic-reticulum-stress-programmed-cell-death-and-oxidative-stress-in-the-small-intestine-of-adult-male-rats
#4
JOURNAL ARTICLE
Anna Pilutin, Sylwia Rzeszotek, Aleksandra Wilk, Klaudia Klimaszewska, Julia Łukasiewicz, Rufaro Lynnette Mafuta, Thanushan Nagendran, Rupia Ndambara, Barbara Wiszniewska
Estrogens are hormones that play an important role in the digestive tract, including in men. Letrozole is an inhibitor of cytochrome P450 aromatase, an enzyme converting androgens to estrogens. The use of letrozole may cause oxidative stress and endoplasmic reticulum stress in the cells. Factors modulating cellular stress may include vitamin C. The purpose of this study was to examine whether letrozole and/or vitamin C supplementation can affect the morphology of the small intestine, the parameters of endoplasmic reticulum stress, programmed cell death markers, and oxidative damage...
March 1, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38533909/use-of-nonhuman-sera-as-a-highly-cost-effective-internal-standard-for-quantitation-of-multiple-human-proteins-using-species-specific-tryptic-peptides-applicability-in-clinical-lc-ms-analyses
#5
JOURNAL ARTICLE
Geraldine Williams, Lewis Couchman, David R Taylor, Jatinderpal K Sandhu, Oliver C Slingsby, Leong L Ng, Cajetan F Moniz, Donald J L Jones, Colleen B Maxwell
Quantitation of proteins using liquid chromatography-tandem mass spectrometry (LC-MS/MS) is complex, with a multiplicity of options ranging from label-free techniques to chemically and metabolically labeling proteins. Increasingly, for clinically relevant analyses, stable isotope-labeled (SIL) internal standards (ISs) represent the "gold standard" for quantitation due to their similar physiochemical properties to the analyte, wide availability, and ability to multiplex to several peptides. However, the purchase of SIL-ISs is a resource-intensive step in terms of cost and time, particularly for screening putative biomarker panels of hundreds of proteins...
March 27, 2024: Journal of Proteome Research
https://read.qxmd.com/read/38533539/lack-of-vitamin-d-signalling-in-mesenchymal-progenitors-causes-fatty-infiltration-in-muscle
#6
JOURNAL ARTICLE
Tohru Hosoyama, Minako Kawai-Takaishi, Hiroki Iida, Yoko Yamamoto, Yuko Nakamichi, Tsuyoshi Watanabe, Marie Takemura, Shigeaki Kato, Akiyoshi Uezumi, Yasumoto Matsui
BACKGROUND: Recent studies have indicated the importance of muscle quality in addition to muscle quantity in sarcopenia pathophysiology. Intramuscular adipose tissue (IMAT), which originates from mesenchymal progenitors (MPs) in adult skeletal muscle, is a key factor affecting muscle quality in older adults, suggesting that controlling IMAT formation is a promising therapeutic strategy for sarcopenia. However, the molecular mechanism underlying IMAT formation in older adults has not been clarified...
March 27, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38532309/contribution-of-nutritional-lifestyle-and-metabolic-risk-factors-to-parkinson-s-disease
#7
JOURNAL ARTICLE
Nicola Veronese, Andrea Nova, Teresa Fazia, Emilia Riggi, Lin Yang, Laura Piccio, Bo-Huei Huang, Matthew Ahmadi, Mario Barbagallo, Maria Notarnicola, Gianluigi Giannelli, Giovanni De Pergola, Emmanuel Stamatakis, Emanuele Cereda, Luisa Bernardinelli, Luigi Fontana
BACKGROUND: Modifiable risk factors for Parkinson's disease (PD) are poorly known. OBJECTIVES: The aim is to evaluate independent associations of different nutritional components, physical activity, and sedentary behavior and metabolic factors with the risk of PD. METHODS: In this population-based prospective cohort study using the data of the United Kingdom Biobank (from 2006-2010), 502,017 men and women who were free from PD (International Classification of Diseases 10th edition; "G20") at baseline were included...
March 26, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38532272/an-integrative-review-of-home-care-recommendations-for-women-after-caesarean-section
#8
REVIEW
Mwajuma Bakari Mdoe, Lilian Teddy Mselle, Stephen Mathew Kibusi
AIM: To describe home-based care and practices recommended for mothers after caesarean section (CS), existing in the literature. DESIGN: Systematic review. METHODS: This integrative literature review was conducted by using Google Scholar, PubMed and Hinari databases from its inception to June 2021. The search included research articles, protocols and guidelines that describe home care practice after CS and assessed for their quality. Synthesis of recommendations from the included literature was classified based on the type of study design, and the review was guided by methodology registered in Prospero (ID CRD42021276905)...
March 2024: Nursing Open
https://read.qxmd.com/read/38532085/effects-of-different-temperatures-on-leiocassis-longirostris-gill-structure-and-intestinal-microbial-composition
#9
JOURNAL ARTICLE
Zhongmeng Zhao, Han Zhao, Xiongyan Wang, Lu Zhang, Chengyan Mou, Zhipeng Huang, Hongyu Ke, Yuanliang Duan, Jian Zhou, Qiang Li
Fish are poikilothermic vertebrates and their physiological activities are affected by water temperature. In recent years, extreme weather has occurred frequently, and temperature changes have adversely affected the growth of farmed fish. To explore the changes in gill tissue structure caused by changing the water temperature and the relationship between the intestinal microbiota and the Leiocassis longirostris host adaptation mechanism, gill tissue sections and intestinal microbial 16S rRNA amplicon sequencing were conducted under different temperature stress (low temperature 4 °C, normal temperature 26 °C and high temperature 32 °C)...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38532074/bacterial-vitamin-b6-is-required-for-post-embryonic-development-in-c-elegans
#10
JOURNAL ARTICLE
Min Feng, Baizhen Gao, Daniela Ruiz, Luis Rene Garcia, Qing Sun
Nutritional intake influences animal growth, reproductive capacity, and survival of animals. Under nutrition deficiency, animal developmental arrest occurs as an adaptive strategy to survive. However, the nutritional basis and the underlying nutrient sensing mechanism essential for animal regrowth after developmental arrest remain to be explored. In Caenorhabditis elegans, larvae undergo early developmental arrest are stress resistant, and they require certain nutrients to recover postembryonic development...
March 26, 2024: Communications Biology
https://read.qxmd.com/read/38531507/complete-genome-sequence-and-transcriptome-response-to-vitamin-c-supplementation-of-novacetimonas-hansenii-si1-producer-of-highly-stretchable-cellulose
#11
JOURNAL ARTICLE
Małgorzata Ryngajłło, Izabela Cielecka, Maurycy Daroch
Novacetimonas hansenii SI1, previously known as Komagataeibacter hansenii, produces bacterial nanocellulose (BNC) with unique ability to stretch. The addition of vitamin C in the culture medium increases the porosity of the membranes and their stretchability making them highly moldable. To better understand the genetic background of this strain, we obtained its complete genome sequence using a hybrid sequencing and assembly strategy. We described the functional regions in the genome which are important for the synthesis of BNC and acetan-like II polymer...
March 24, 2024: New Biotechnology
https://read.qxmd.com/read/38530258/common-oral-conditions-a-review
#12
JOURNAL ARTICLE
Eric T Stoopler, Alessandro Villa, Mohammed Bindakhil, David L Ojeda Díaz, Thomas P Sollecito
IMPORTANCE: Dry mouth, oral candidiasis, and recurrent aphthous ulcers are 3 of the most common oral conditions that may be associated with patient discomfort, decreased quality of life, and morbidity. OBSERVATIONS: In a meta-analysis of 26 population-based cohort and cross-sectional studies, the global prevalence of dry mouth symptoms was 23% (95% CI, 18% to 28%), placing individuals at risk of oral candidiasis, dental caries, dysgeusia, masticatory/speech impairment, and oropharyngeal dysphagia...
March 26, 2024: JAMA
https://read.qxmd.com/read/38529770/nutritional-impact-of-no-added-sugar-fruit-puree-consumption-at-different-eating-occasions-a-modelling-study-on-french-children
#13
JOURNAL ARTICLE
Romane Poinsot, Céline Richonnet, Florent Vieux
OBJECTIVE: The recommended level of 5 fruits and vegetables per day is reached by a minority of French children. No-added sugars fruit puree (NASFP) can be consumed as a complement of fresh fruit to meet the recommendation for fruits and vegetables. The objective was to simulate the nutritional impact of an increase in consumption of NAFP among French children, together with a reduction in sweetened foods. DESIGN: The study was conducted on French children aged 1 to 17...
March 26, 2024: Public Health Nutrition
https://read.qxmd.com/read/38529712/engineering-the-carbon-and-redox-metabolism-of-paenibacillus-polymyxa-for-efficient-isobutanol-production
#14
JOURNAL ARTICLE
Meliawati Meliawati, Daniel C Volke, Pablo I Nikel, Jochen Schmid
Paenibacillus polymyxa is a non-pathogenic, Gram-positive bacterium endowed with a rich and versatile metabolism. However interesting, this bacterium has been seldom used for bioproduction thus far. In this study, we engineered P. polymyxa for isobutanol production, a relevant bulk chemical and next-generation biofuel. A CRISPR-Cas9-based genome editing tool facilitated the chromosomal integration of a synthetic operon to establish isobutanol production. The 2,3-butanediol biosynthesis pathway, leading to the main fermentation product of P...
March 2024: Microbial Biotechnology
https://read.qxmd.com/read/38529360/assessment-of-nutrients-intake-in-pediatrics-with-type-1-diabetes-and-dyslipidemia-in-jordan
#15
JOURNAL ARTICLE
Reema Tayyem, Hala Nawaiseh, Sara Basem Zakarneh, Yasmen Khial, Sabika Allehdan
BACKGROUND: Dyslipidemias are disorders of lipoprotein metabolism that occur during childhood and adolescence, often persist into adulthood, and increase the risk of developing atherosclerotic lesions. This study aimed to assess the potential association between nutrient intake and dyslipidemia in Jordanian pediatric patients diagnosed with type 1 diabetes mellitus. METHODS: This cross-sectional study was conducted in Amman, Jordan, and involved 90 children and adolescents diagnosed with type 1 diabetes mellitus...
2024: Adolescent Health, Medicine and Therapeutics
https://read.qxmd.com/read/38528743/c-reactive-protein-as-a-novel-biomarker-for-vitamin-d-deficiency-in-alopecia-areata
#16
JOURNAL ARTICLE
Ahmed Ibrahim AbdElneam, Mohammed Saleh Al-Dhubaibi, Saleh Salem Bahaj, Ghada Farouk Mohammed, Ahmed Kaid Alantry, Lina Mohamed Atef
BACKGROUND: Alopecia areata (AA) is an autoimmune condition characterized by sudden and unpredictable hair loss, with a lifetime incidence of 2%. AA can be divided into three categories: patchy alopecia, alopecia totalis, and alopecia universalis. It can affect a person's psychological health and overall quality of life. Elevated C-reactive protein (CRP) levels in the liver may indicate an inflammatory response in autoimmune diseases. Vitamin D, essential for immune system control and skin health, may be related to AA...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38528391/curcumin-and-omega-3-polyunsaturated-fatty-acids-as-bioactive-food-components-with-synergistic-effects-on-alzheimer-s-disease
#17
REVIEW
Luz Del C Velasco-Rodríguez, Hugo S García, Martha P Rascón-Díaz
Curcumin and omega-3 polyunsaturated fatty acids (ω-3 PUFA) are multifunctional compounds which play an important role in Alzheimer's disease (AD) and little has been addressed about the role of these two compounds together in the progression of the disease. There is evidence of the beneficial effect of combined administration of ω-3 PUFA and other dietary supplements such as vitamins and polyphenols in the prevention of AD, although much remains to be understood about their possible complementary or synergistic activity...
March 25, 2024: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://read.qxmd.com/read/38528176/a-combination-nutritional-supplement-reduces-dna-methylation-age-only-in-older-adults-with-a-raised-epigenetic-age
#18
JOURNAL ARTICLE
Kirsty C McGee, Jack Sullivan, Jon Hazeldine, Lisa J Schmunk, Daniel E Martin-Herranz, Thomas Jackson, Janet M Lord
An increase in systemic inflammation (inflammaging) is one of the hallmarks of aging. Epigenetic (DNA methylation) clocks can quantify the degree of biological aging and this can be reversed by lifestyle and pharmacological intervention. We aimed to investigate whether a multi-component nutritional supplement could reduce systemic inflammation and epigenetic age in healthy older adults.We recruited 80 healthy older participants (mean age ± SD: 71.85 ± 6.23; males = 31, females = 49)...
March 26, 2024: GeroScience
https://read.qxmd.com/read/38526590/effect-of-indian-gooseberry-extract-on-improving-methylglyoxal-associated-leptin-resistance-in-peripheral-tissues-of-high-fat-diet-fed-rats
#19
JOURNAL ARTICLE
Sheng-Yi Chen, Yue-Ning Huang, Jer-An Lin, Gow-Chin Yen
Increased leptin resistance and methylglyoxal (MG) levels are observed in obese patients. However, whether MG deposits contribute to leptin resistance, oxidative stress, and inflammation in peripheral tissues remains unclear. In addition, the edible fruit of Indian gooseberry (Phyllanthus emblica L.) contains abundant bioactive components such as vitamin C, β-glucogallin (β-glu), gallic acid (GA), and ellagic acid (EA). Water extract of Indian gooseberry fruit (WEIG) and GA has been shown to improve cognitive decline by suppressing brain MG-induced insulin resistance in rats administered a high-fat diet (HFD)...
March 15, 2024: Journal of Food and Drug Analysis
https://read.qxmd.com/read/38526295/flexible-triboelectric-nanogenerator-for-promoting-the-proliferation-and-migration-of-human-fibroblast-cells
#20
JOURNAL ARTICLE
Razieh Nazari-Vanani, Mohaddeseh Vafaiee, Fahimeh Zamanpour, Elham Asadian, Raheleh Mohammadpour, Hashem Rafii-Tabar, Pezhman Sasanpour
Chronic wound healing is often a prolonged process with the migration and proliferation of fibroblast cells playing crucial roles. Electrical stimulation (ES) has emerged as a promising physical therapy modality to promote these key events. In this study, we address this issue by employing a triboelectric nanogenerator (TENG) as an electrical stimulator for both drug release and the stimulation of fibroblast cells. The flexible TENG with a sandwich structure was fabricated using a PCL nanofibrous layer, Kapton, and silicon rubber...
March 25, 2024: ACS Applied Materials & Interfaces
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