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https://www.readbyqxmd.com/read/28712005/an-overview-of-the-ongoing-insights-in-selenium-research-and-its-role-in-fish-nutrition-and-fish-health
#1
REVIEW
Kifayat Ullah Khan, Amina Zuberi, João Batista Kochenborger Fernandes, Imdad Ullah, Huda Sarwar
In the present review, the ongoing researches about selenium research in fish nutrition have been comprehensively discussed. Selenium research is getting popularity in fish nutrition as it is required for the normal growth and proper physiological and biochemical functions in fish. Its deficiency or surplus amounts create severe problems in fish. It is available as inorganic form, organic form, and nano form. In fish, most of the previous research is about the selenium requirements for fish by using only one selenium source mainly the inorganic one...
July 15, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28702279/the-utilization-of-selenocysteine-trna-ser-sec-isoforms-is-regulated-in-part-at-the-level-of-translation-in-vitro
#2
Bradley A Carlson, Nirupama Gupta, Mark H Pinkerton, Dolph L Hatfield, Paul R Copeland
The tRNA for the 21st proteinogenic amino acid, selenocysteine, exists in mammalian cells as 2 isoforms differing by a single 2'-O-methylribosyl moiety at position 34 (Um34). These isoforms contain either 5-methoxycarbonylmethyluridine (mcm(5)U) or 5-methoxycarbonylmethyl-2'-O-methyluridine (mcm(5)Um) at position 34. The accumulation of the mcm(5)Um isoform is tightly correlated with the expression of nonessential "stress response" selenoproteins such as glutathione peroxidase 1 (GPX1). The expression of essential selenoproteins, such as thioredoxin reductase 1 (TXNRD1), is not affected by changes in Sec-tRNA([Ser]Sec) isoform accumulation...
2017: Translation
https://www.readbyqxmd.com/read/28700468/identification-of-sepp1-polymorphisms-is-not-a-genetic-risk-factor-for-preeclampsia-in-chinese-han-women-a-clinical-trial-and-experimental-study
#3
Hong Wu, Xuewen Jia, Hong Zhao, Youmin Huang, Chang Liu, Zuzhou Huang, Shunjun Li, Jingli Wang
BACKGROUND: SEPP1 encodes selenoprotein P, which involved in oxidative stress and plays an important role in the development of preeclampsia (PE). The aim of this study was to investigate the association between PE and genetic variants of SEPP1 in Chinese Han women. METHODS: In all, 2434 unrelated pregnant women were recruited, including 1034 PE cases and 1400 normal pregnant controls. TaqMan allelic discrimination real-time PCR method was used to genotype the 2 polymorphisms of rs7579 and rs230813 in SEPP1...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28698597/selenoprotein-msrb1-promotes-anti-inflammatory-cytokine-gene-expression-in-macrophages-and-controls-immune-response-in-vivo
#4
Byung Cheon Lee, Sang-Goo Lee, Min-Kyung Choo, Ji Hyung Kim, Hae Min Lee, Sorah Kim, Dmitri E Fomenko, Hwa-Young Kim, Jin Mo Park, Vadim N Gladyshev
Post-translational redox modification of methionine residues often triggers a change in protein function. Emerging evidence points to this reversible protein modification being an important regulatory mechanism under various physiological conditions. Reduction of oxidized methionine residues is catalyzed by methionine sulfoxide reductases (Msrs). Here, we show that one of these enzymes, a selenium-containing MsrB1, is highly expressed in immune-activated macrophages and contributes to shaping cellular and organismal immune responses...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28696394/influence-of-genetic-variations-in-selenoprotein-genes-on-the-pattern-of-gene-expression-after-supplementation-with-brazil-nuts
#5
Janaina L S Donadio, Marcelo M Rogero, Simon Cockell, John Hesketh, Silvia M F Cozzolino
Selenium (Se) is an essential micronutrient for human health. Its beneficial effects are exerted by selenoproteins, which can be quantified in blood and used as molecular biomarkers of Se status. We hypothesize that the presence of genetic polymorphisms in selenoprotein genes may: (1) influence the gene expression of specific selenoproteins and (2) influence the pattern of global gene expression after Brazil nut supplementation. The study was conducted with 130 healthy volunteers in Sao Paulo, Brazil, who consumed one Brazil nut (300 μg/Se) a day for eight weeks...
July 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28663583/aminoglycoside-driven-biosynthesis-of-selenium-deficient-selenoprotein-p
#6
Kostja Renko, Janine Martitz, Sandra Hybsier, Bjoern Heynisch, Linn Voss, Robert A Everley, Steven P Gygi, Mette Stoedter, Monika Wisniewska, Josef Köhrle, Vadim N Gladyshev, Lutz Schomburg
Selenoprotein biosynthesis relies on the co-translational insertion of selenocysteine in response to UGA codons. Aminoglycoside antibiotics interfere with ribosomal function and may cause codon misreading. We hypothesized that biosynthesis of the selenium (Se) transporter selenoprotein P (SELENOP) is particularly sensitive to antibiotics due to its ten in frame UGA codons. As liver regulates Se metabolism, we tested the aminoglycosides G418 and gentamicin in hepatoma cell lines (HepG2, Hep3B and Hepa1-6) and in experimental mice...
June 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28660949/selenoproteins-are-involved-in-antioxidant-defense-systems-in-thalassemia
#7
REVIEW
G E Genc, Z Ozturk, S Gumuslu
Thalassemia major (TM) is a hereditary blood disease that affects the production of hemoglobin, resulting in severe anemia. Iron overload because of repeated blood transfusion and increased intestinal iron absorption and hemolysis are the major causes of increased oxidative stress in these patients. Growth and maturational delay, cardiomyopathy, endocrinopathies, and osteoporosis are the complications of thalassemia, secondary to anemia and iron overload. The human body has endogenous defense mechanisms to help protect against free radical-induced cell damage...
June 29, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28650663/overexpression-and-lowexpression-of-selenoprotein-s-impact-ochratoxin-a-induced-porcine-cytotoxicity-and-apoptosis-in-vitro
#8
Fang Gan, Zhihua Hu, Yajiao Zhou, Kehe Huang
Our previous study demonstrated that selenium could alleviate ochratoxin A (OTA)-induced nephrotoxicity in PK15 cells. Selenoprotein S (SelS) has antioxidant activities, but it is unclear whether SelS plays a role in the alleviating effects of selenium on OTA-induced nephrotoxicity. We previously have stably transfected pig pCDNA3.1-SelS to PK15 cells to over-express SelS. Here, we demonstrated that SelS overexpression alleviated OTA-induced cytotoxicity and apoptosis as demonstrated by cell viabilities, LDH activities, Annexin V-bing, caspase 3 activities and apoptotic nuclei...
June 26, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28634813/long-term-excessive-selenium-supplementation-induces-hypertension-in-rats
#9
Denise Grotto, Maria Fernanda Hornos Carneiro, Michele Mazzaron de Castro, Solange Cristina Garcia, Fernando Barbosa Junior
Selenium (Se) is an essential trace element involved in several biological pathways, naturally found in rocks, soils, and food. Even though the daily requirement of Se is achieved through a balanced diet, the use of Se supplements has been frequent. Due to the risk of toxic effects of having Se in excess, supplementation is still under debate. The aim was to evaluate the effects of long-term Se supplementation upon systolic blood pressure (SBP) and redox status of rats exposed to sodium selenite. Male Wistar rats were exposed to 2 and 6 mg/L of sodium selenite in drinking water for 85 days...
June 20, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28627816/spectrophotometric-determination-of-selenium-through-triiodide-anion
#10
Otilia Bizerea-Spiridon, Radu Nartita, Alexandru F Rogobete, Adina Negrea, Ramona Stroescu, Teofana O Bizerea, Constantin Ilie, Otilia Marginean
BACKGROUND: Selenium is a chemical element found in the human body that plays a crucial role in its regulation. Depending on the concentration, it may have beneficial or have toxic effects. Selenium is incorporated as selenocysteine amino acid residue in selenoproteins which play an important role in many biological functions: anti-oxidant defense, regulation of the immune function and of the inflammatory response, metabolism of thyroid hormones, functioning of the central nervous system, biosynthesis of DNA and RNA, fertility, and reproduction...
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28623977/loss-of-selenocysteine-insertion-sequence-binding-protein-2-suppresses-the-proliferation-migration-invasion-and-hormone-secretion-of-human-trophoblast-cells-via-the-pi3k-akt-and-erk-signaling-pathway
#11
Mengdi Li, Wanpeng Cheng, Jincheng Luo, Xiaoyan Hu, Tingting Nie, Hehuan Lai, Xiaolin Zheng, Fenglan Li, Hui Li
INTRODUCTION: Selenocysteine insertion binding protein 2 (SECISBP2) plays a vital role in selenocysteine incorporation into selenoprotein in many creatures. However, the impact of SECISBP2 in development of trophoblast cells remains unclear. The aim of this study was to investigate the roles of SECISBP2 in human trophoblast cells and the underlying molecular mechanism. METHODS: Low-expression of SECISBP2 in trophoblast cells was achieved by transfection with siRNAs...
July 2017: Placenta
https://www.readbyqxmd.com/read/28621339/hepatokines-linking-nonalcoholic-fatty-liver-disease-and-insulin-resistance
#12
REVIEW
Ruth C R Meex, Matthew J Watt
Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which is the most common form of liver disease and is present in up to ∼70% of individuals who are overweight. NAFLD is also associated with hypertriglyceridaemia and low levels of HDL, glucose intolerance, insulin resistance and type 2 diabetes mellitus. Hepatic steatosis is a strong predictor of the development of insulin resistance and often precedes the onset of other known mediators of insulin resistance. This sequence of events suggests that hepatic steatosis has a causal role in the development of insulin resistance in other tissues, such as skeletal muscle...
June 9, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28619231/endoplasmic-reticulum-chaperones-tweak-the-mitochondrial-calcium-rheostat-to-control-metabolism-and-cell-death
#13
REVIEW
Tomas Gutiérrez, Thomas Simmen
The folding of secretory proteins is a well-understood mechanism, based on decades of research on endoplasmic reticulum (ER) chaperones. These chaperones interact with newly imported polypeptides close to the ER translocon. Classic examples for these proteins include the immunoglobulin binding protein (BiP/GRP78), and the lectins calnexin and calreticulin. Although not considered chaperones per se, the ER oxidoreductases of the protein disulfide isomerase (PDI) family complete the folding job by catalyzing the formation of disulfide bonds through cysteine oxidation...
May 31, 2017: Cell Calcium
https://www.readbyqxmd.com/read/28595796/the-metal-and-metalloprotein-profile-of-human-plasma-as-biomarkers-for-stroke-diagnosis
#14
Keaton S Nahan, Kyle B Walsh, Opeolu Adeoye, Julio A Landero-Figueroa
Stroke, a major cause of disability and mortality, affects someone in the United States every 40s. Stroke biomarkers, including those that could be used as a blood test for diagnosis of stroke, have been particularly elusive. We performed a double blind study to identify human plasma biomarkers for the diagnosis of stroke, including acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH). We utilized a three-track approach based on the total metal profile, the metal cofactor levels among metalloproteins, and the identification of stroke-related metalloproteins...
July 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28592916/a-reduction-in-selenoprotein-s-amplifies-the-inflammatory-profile-of-fast-twitch-skeletal-muscle-in-the-mdx-dystrophic-mouse
#15
Craig Robert Wright, Giselle Larissa Allsopp, Alex Bernard Addinsall, Natasha Lee McRae, Sofianos Andrikopoulos, Nicole Stupka
Excessive inflammation is a hallmark of muscle myopathies, including Duchenne muscular dystrophy (DMD). There is interest in characterising novel genes that regulate inflammation due to their potential to modify disease progression. Gene polymorphisms in Selenoprotein S (Seps1) are associated with elevated proinflammatory cytokines, and in vitro SEPS1 is protective against inflammatory stress. Given that SEPS1 is highly expressed in skeletal muscle, we investigated whether the genetic reduction of Seps1 exacerbated inflammation in the mdx mouse...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28579431/direct-interaction-between-selenoprotein-r-and-a%C3%AE-42
#16
Chao Wang, Ping Chen, Xiaohong He, Zaisheng Peng, Siqiang Chen, Renli Zhang, Jinquan Cheng, Qiong Liu
Amyloid-β (Aβ) peptides have taken a central role in AD research, the aggregation of Aβ peptide is involved in the progression of Alzheimer's disease (AD). The 35th amino acid was methionine (Met) in Aβ peptides and it's redox state is critical in determining the biological activity of Aβ. It has been suggested that oxidation of Met(35) (Met(35)O) plays a key role in the formation of paranuclei and in the control of oligomerization pathway choice. As an antioxidative selenoenzyme, Selenoprotein R (SelR) plays important roles in reducing the R-form of MetO to Met to maintain intracellular redox balance...
June 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28579252/biological-implications-of-selenium-in-adolescent-rats-exposed-to-binge-drinking-oxidative-immunologic-and-apoptotic-balance
#17
M Luisa Ojeda, Olimpia Carreras, Paula Sobrino, M Luisa Murillo, Fátima Nogales
Alcohol intermittent binge drinking (BD) during adolescence decreases the levels of selenium (Se), a trace element that plays a key biological role against oxidative damage in hepatocytes through different selenoproteins such as the antioxidant enzymes glutathione peroxidases (GPx1 and Gpx4) and selenoprotein P (SelP). In this context, it has been found that GPx4 has an essential antioxidant role in mitochondria modulating the apoptosis and NF-kB activation (a factor intimately related to apoptosis and immune function)...
June 1, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28574376/recent-advances-in-the-mechanism-of-selenoamino-acids-toxicity-in-eukaryotic-cells
#18
REVIEW
Myriam Lazard, Marc Dauplais, Sylvain Blanquet, Pierre Plateau
Selenium is an essential trace element due to its incorporation into selenoproteins with important biological functions. However, at high doses it is toxic. Selenium toxicity is generally attributed to the induction of oxidative stress. However, it has become apparent that the mode of action of seleno-compounds varies, depending on its chemical form and speciation. Recent studies in various eukaryotic systems, in particular the model organism Saccharomyces cerevisiae, provide new insights on the cytotoxic mechanisms of selenomethionine and selenocysteine...
May 24, 2017: Biomolecular Concepts
https://www.readbyqxmd.com/read/28571752/insights-into-the-differential-toxicological-and-antioxidant-effects-of-4-phenylchalcogenil-7-chloroquinolines-in-caenorhabditis-elegans
#19
Willian G Salgueiro, Bruna S Goldani, Tanara V Peres, Antonio Miranda-Vizuete, Michael Aschner, João Batista Teixeira da Rocha, Diego Alves, Daiana S Ávila
Organic selenium and tellurium compounds are known for their broad-spectrum effects in a variety of experimental disease models. However, these compounds commonly display high toxicity and the molecular mechanisms underlying these deleterious effects have yet to be elucidated. Thus, the need for an animal model that is inexpensive, amenable to high-throughput analyses, and feasible for molecular studies is highly desirable to improve organochalcogen pharmacological and toxicological characterization. Herein, we use Caenorhabdtis elegans (C...
May 30, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28558865/early-onset-of-sleep-disordered-breathing-in-two-children-with-sepn1-related-myopathies
#20
Mathilde Viprey, Ha Trang, Michaël Pomedio, Katia Bessaci-Kabouya, Pascal Sabouraud, Fawzia Cheliout-Heraut, Pierre Mauran
Selenoprotein-related myopathy (SEPN1-RM) is a rare disease with a variable clinical presentation. The selenoproteinN1 gene (SEPN1) mutation causingthis congenital muscular dystrophy was identified in 2001. Sleep-disordered breathing (SDB) may occur in young patients with SEPN1-RM who are stillable to walk. We report the cases of two children with SEPN1-RM who presented with SDB at the ages of 7 and 12 years and for whom long-term nocturnalnoninvasive ventilation yielded significant improvement. Based on literature review and our current cases, it seems that there is no obvious relationshipbetween the time since SDB onset and outcome of pulmonary function tests or limb muscle weakness...
May 25, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
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