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https://www.readbyqxmd.com/read/28429287/protective-effect-of-selenoprotein-x-against-oxidative-stress-induced-cell-apoptosis-in-human-hepatocyte-lo2-cells-via-the-p38-pathway
#1
Jia-Yong Tang, Ai-Hua He, Gang Jia, Guang-Mang Liu, Xiao-Ling Chen, Jing-Yi Cai, Hai-Ying Shang, Jin-Qiu Liao, Hua Zhao
Oxidative stress, as mediated by ROS (reactive oxygen species), is a significant factor in initiating the cells damaged by affecting cellular macromolecules and impairing their biological functions; SelX, a selenoprotein also known as MsrB1 belonging to the methionine sulfoxide reductase (Msr) family, is the redox repairing enzyme and involved in redox-related functions. In order to more precisely analyze the relationship between oxidative stress, cell oxidative damage, and SelX, we stably overexpressed porcine Selx full-length cDNA in human normal hepatocyte (LO2) cells...
April 20, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28429286/effects-of-selenium-supplementation-on-the-diabetic-condition-depend-on-the-baseline-selenium-status-in-kkay-mice
#2
Novian Febiyanto, Chiho Yamazaki, Satomi Kameo, Dian K Sari, Irma M Puspitasari, Deni K Sunjaya, Dewi M D Herawati, Gaga I Nugraha, Toshio Fukuda, Hiroshi Koyama
Oxidative stress in obesity leads to insulin resistance in type 2 diabetes. Some selenoproteins possess antioxidant properties, suggesting that selenium (Se) may protect against type 2 diabetes; however, evidence from epidemiological studies is contradictory. We hypothesized that Se status before supplementation (baseline) contributes to the supplementation outcome. This study aimed to clarify the influence of baseline Se status on the effect of Se supplementation on the diabetic condition. Six-week-old KKAy mice were fed a diet without supplemental Se or with 0...
April 20, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28424960/selenium-for-the-mitigation-of-toxicity-induced-by-lead-in-chicken-testes-through-regulating-mrna-expressions-of-hsps-and-selenoproteins
#3
He Huang, Yan Wang, Yang An, Yaguang Tian, Shu Li, Xiaohua Teng
Lead (Pb) is a toxic element and environmental pollutant. Pb toxicity and antagonistic effect of selenium (Se) on Pb have been deeply studied in mammals. The testis is one of the target organs of Pb in birds. The aim of this study was to investigate the mitigating effect of Se on Pb toxicity in chicken testes by determining messenger RNA (mRNA) expressions of 5 heat shock proteins (HSPs) and 25 selenoproteins. Sixty male chickens (7-day-old) were randomly divided into the control group, the Se group, the Pb group, and the Pb + Se group, and were fed for 90 days...
April 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28415800/selenophosphate-synthetase-1-sps1-is-required-for-the-development-and-selenium-homeostasis-of-central-nervous-system-in-chicken-gallus-gallus
#4
Jin-Long Li, Wei Li, Xue-Tong Sun, Jun Xia, Xue-Nan Li, Jia Lin, Cong Zhang, Xiao-Chen Sun, Shi-Wen Xu
Selenophosphate synthetase (SPS) is essential for selenoprotein biosynthesis. In two SPS paralogues, SPS1 was only cloned from a cDNA library prepared from avian organ. However, the biological function of SPS1 in chicken central nervous system (CNS) remains largely unclear. To investigate the role of avian SPS1 in the development and selenium (Se) homeostasis of CNS, fertile eggs, chicken embryos, embryo neurons and chicks were employed in this study. The response of SPS1 transcription to the development and Se levels of CNS tissues was analyzed using qRT-PCR...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414460/analysis-of-novel-interactions-between-components-of-the-selenocysteine-biosynthesis-pathway-sephs1-sephs2-sepsecs-and-secp43
#5
Flore Oudouhou, Bastien Casu, Arnold Steve Dopgwa Puemi, Jurgen Sygusch, Christian Baron
In mammalian cells, the incorporation of the 21st amino acid, selenocysteine, into proteins is guided by the Sec machinery. The function of this protein complex requires several protein-protein and protein-RNA interactions, leading to the incorporation of selenocysteine at UGA codons. It is guided by stem-loop structures localized in the 3' untranslated regions of the selenoprotein-encoding genes. Here, we conducted a global analysis of interactions between the Sec biosynthesis and incorporation components using a bioluminescence resonance energy transfer assay in mammalian cells that showed that selenocysteine synthase (SEPSECS), SECp43, and selenophosphate synthetases SEPHS1 and SEPHS2 form oligomers in eukaryotic cells...
April 20, 2017: Biochemistry
https://www.readbyqxmd.com/read/28412747/selenomethionine-and-methyl-selenocysteine-multiple-dose-pharmacokinetics-in-selenium-replete-men
#6
James R Marshall, Raymond F Burk, Rochelle Payne Ondracek, Kristina E Hill, Marjorie Perloff, Warren Davis, Roberto Pili, Saby George, Raymond Bergan
According to the Nutritional Prevention of Cancer (NPC) trial, a selenized yeast supplement containing selenium, 200 mcg/day, decreased the incidence of total cancer, cancers of the prostate, colon and lung, and cancer mortality. The active agent in the selenized yeast supplement was assumed to be selenomethionine (SEMET), although the supplement had not been well speciated. The SELECT study, largely motivated by the NPC trial, enrolling nearly 40 times as many subjects, showed unequivocally that selenium 200 mcg/day, with selenium in the form of SEMET, does not protect selenium-replete men against prostate or other major cancer...
February 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28409884/altered-protein-expression-pattern-in-colon-tissue-of-mice-upon-supplementation-with-distinct-selenium-compounds
#7
Jette Rahn, Claudia Lennicke, Anna P Kipp, Andreas S Müller, Ludger A Wessjohann, Rudolf Lichtenfels, Barbara Seliger
The essential trace element Selenium (Se) is controversially discussed concerning its role in health and disease. Its various physiological functions are largely mediated by Se incorporation in the catalytic center of selenoproteins. To gain insights into the impact of Se deficiency and of supplementation with different Se compounds (selenite, selenate, selenomethionine) at defined concentrations (recommended, 150 μg/ kg diet; excessive, 750 μg/ kg diet) in murine colon tissues a twenty week feeding experiment was performed followed by analysis of the protein expression pattern of colon tissue specimens by 2D-DIGE and MALDI-TOF MS...
April 14, 2017: Proteomics
https://www.readbyqxmd.com/read/28409122/a-post-publication-analysis-of-the-idealized-upper-reference-value-of-2-5%C3%A2-miu-l-for-tsh-time-to-support-the-thyroid-axis-with-magnesium-and-iron-especially-in-the-setting-of-reproduction-medicine
#8
Roy Moncayo, Helga Moncayo
Laboratory medicine approaches the evaluation of thyroid function mostly through the single determination of the blood level of thyroid stimulating hormone (TSH). Some authors have suggested an upper reference value for TSH of 2.5 mIU/L. This suggestion has not been confirmed by recent clinical studies. These studies have delivered a clinically valid reference range going from 0.3 to 3.5 mIU/L. These values are valid for both for the general population as well as in the setting of fertility and pregnancy...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/28356430/a-novel-organic-selenium-compound-exerts-unique-regulation-of-selenium-speciation-selenogenome-and-selenoproteins-in-broiler-chicks
#9
Ling Zhao, Lv-Hui Sun, Jia-Qiang Huang, Mickael Briens, De-Sheng Qi, Shi-Wen Xu, Xin Gen Lei
Background: A new organic selenium compound, 2-hydroxy-4-methylselenobutanoic acid (SeO), displayed a greater bioavailability than sodium selenite (SeNa) or seleno-yeast (SeY) in several species.Objective: This study sought to determine the regulation of the speciation of selenium, expression of selenogenome and selenocysteine biosynthesis and degradation-related genes, and production of selenoproteins by the 3 forms of selenium in the tissues of broiler chicks.Methods: Day-old male chicks (n = 6 cages/diet, 6 chicks/cage) were fed a selenium-deficient, corn and soy-based diet [base diet (BD), 0...
March 29, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28347729/selenoprotein-t-is-required-for-pathogenic-bacteria-avoidance-in-caenorhabditis-elegans
#10
Laura Romanelli-Cedrez, Inés Carrera, Lucía Otero, Antonio Miranda-Vizuete, Marco Mariotti, Mark J Alkema, Gustavo Salinas
Selenoprotein T (SELENOT) is an endoplasmatic reticulum (ER)-associated redoxin that contains the amino acid selenocysteine (Sec, U) within a CXXU motif within a thioredoxin-like fold. Its precise function in multicellular organisms is not completely understood although it has been shown in mammals to be involved in Ca(2+) homeostasis, antioxidant and neuroendocrine functions. Here, we use the model organism C. elegans to address SELENOT function in a whole organism throughout its life cycle. C. elegans possess two genes encoding SELENOT protein orthologues (SELT-1...
March 24, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28339058/toenail-selenium-as-an-indicator-of-environmental-exposure-a-cross-sectional-study
#11
Tommaso Filippini, Angela Ferrari, Bernhard Michalke, Peter Grill, Luciano Vescovi, Chiara Salvia, Carlotta Malagoli, Marcella Malavolti, Sabina Sieri, Vittorio Krogh, Annalisa Bargellini, Antonio Martino, Margherita Ferrante, Marco Vinceti
The relation between toxicity and essentiality of selenium (Se) is of growing interest in human health, as the effects may widely differ depending of its different chemical species and the exposure levels. Toenail Se has been proposed as a reliable biomarker of long-term Se exposure, but few studies investigated the correlation between its toenail content and environmental determinants (i.e., dietary food intake). We aimed to determine the relation of toenail Se levels with serum Se species as well as food items...
March 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28315680/selenoprotein-s-is-required-for-clearance-of-c99-through-endoplasmic-reticulum-associated-degradation
#12
Jun Ki Jang, Ki Jun Park, Jea Hwang Lee, Kwan Young Ko, Seongman Kang, Ick Young Kim
Amyloid beta precursor protein (APP) is normally cleaved by α-secretase, but can also be cleaved by β-secretase (BACE1) to produce C99 fragments in the endoplasmic reticulum (ER) membrane. C99 is subsequently cleaved to amyloid β (Aβ), the aggregation of which is known to cause Alzheimer's disease. Therefore, C99 removing is for preventing the disease. Selenoprotein S (SelS) is an ER membrane protein participating in endoplasmic reticulum-associated degradation (ERAD), one of the stages in resolving ER stress of misfolded proteins accumulated in the ER...
March 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28304024/methionine-and-seleno-methionine-type-peptide-and-peptoid-building-blocks-synthesized-by-five-component-five-center-reactions
#13
Goran N Kaluđerović, Muhammad Abbas, Hans Christian Kautz, Mohammad A M Wadaan, Claudia Lennicke, Barbara Seliger, Ludger A Wessjohann
A first example of 5-component 5-center reactions with isonitriles [Ugi-5CRs] is described. The extended Ugi type reactions involve selenoaldehydes as well as ammonia, both challenging reactants in multicomponent (MCR) systems, to generate methionine and Se-methionine moieties and derivatives as protected building blocks or for direct ligation in peptides or peptoids. The peptoid/peptide building blocks proved to be non-cytotoxic but increased the expression of genes encoding for stress protective selenoproteins (Gpx1)...
March 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28290237/multiple-nutritional-factors-and-the-risk-of-hashimoto-s-thyroiditis
#14
Shiqian Hu, Margaret P Rayman
BACKGROUND: Hashimoto's thyroiditis (HT) is considered to be the most common autoimmune disease. It is currently accepted that genetic susceptibility, environmental factors, and immune disorders contribute to its development. With regard to nutritional factors, evidence implicates high iodine intake and deficiencies of selenium and iron with a potential relevance of vitamin D status. To elucidate the role of nutritional factors in the risk, pathogenesis, and treatment of HT, PubMed and the Cochrane Library were searched for publications on iodine, iron, selenium, and vitamin D and risk/treatment of HT...
April 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28286015/rutin-protects-against-h2o2-triggered-impaired-relaxation-of-placental-arterioles-and-induces-nrf2-mediated-adaptation-in-human-umbilical-vein-endothelial-cells-exposed-to-oxidative-stress
#15
Mireille M J P E Sthijns, Paul M Schiffers, Ger M Janssen, Kristien J A Lemmens, Bart Ides, Philippe Vangrieken, Freek G Bouwman, Edwin C Mariman, Irina Pader, Elias S J Arnér, Katarina Johansson, Aalt Bast, Guido R M M Haenen
BACKGROUND: Rutin intake is associated with a reduced risk of cardiovascular disease (CVD). The exact mechanism by which rutin can protect against CVD development is still enigmatic. Since, rutin is a compound with a relatively short half-life, the direct antioxidant effect of rutin cannot explain the long-lasting effect on human health. We hypothesized that rutin next to its direct antioxidant effect that improves endothelial function, may also induce an adaptive response in endogenous antioxidant systems...
March 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28285519/selenomethionine-alleviates-afb1-induced-damage-in-primary-chicken-hepatocytes-by-inhibiting-cyp450-1a5-expression-via-upregulated-selw-expression
#16
Xingxiang Chen, Chaoping Che, Viktor I Korolchuk, Fang Gan, Cuiling Pan, Kehe Huang
This study aims to evaluate the protective effects of selenomethionine (SeMet) on aflatoxin B1 (AFB1)-induced hepatotoxicity in primary chicken hepatocytes. Cell viability and lactic dehydrogenase activity assays revealed the dose dependence of AFB1 toxicity to chicken hepatocytes. AFB1 concentrations of >0.05 μg/mL significantly reduced glutathione and total superoxide dismutase levels and increased the malondialdehyde concentration and cytochrome P450 enzyme 1A5 (CYP450 1A5) mRNA levels (P < 0.05)...
March 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28281222/gene-silencing-of-selenoprotein-k-induces-inflammatory-response-and-activates-heat-shock-proteins-expression-in-chicken-myoblasts
#17
Ruifeng Fan, Haidong Yao, Changyu Cao, Xia Zhao, Ahmed Khalid, Jinxin Zhao, Ziwei Zhang, Shiwen Xu
In the present study, specific small interfering RNA (siRNA) for selenoprotein K (Selk) gene was designed and transfected into chicken myoblasts. Then, the expressions of inflammatory factors (including induced nitric oxide synthase [iNOS], nuclear factor-kappa B [NF-κB], heme-oxygenase-1 [HO-1], cyclooxygenase-2 [COX-2], and prostaglandin E synthase [PTGEs]), inflammation-related cytokines (including interleukin [IL]-1β, IL-6, IL-7, IL-8, IL-17, and interferon [IFN]-γ), and heat shock proteins (HSPs) (including HSP27, HSP40, HSP60, HSP70, and HSP90) were examined at 24 and 72 h after transfection...
March 9, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28273633/hepatoprotective-efficacy-of-nigella-sativa-seeds-dietary-supplementation-against-lead-acetate-induced-oxidative-damage-in-rabbit-purification-and-characterization-of-glutathione-peroxidase
#18
Ali H El-Far, Mahdy A Korshom, Abdelwahab A Mandour, Ashraf A El-Bessoumy, Yasser S El-Sayed
Lead (Pb) is a toxic ubiquitous environmental pollutant that induces hepatotoxicity in both animals and humans. The ability of Nigella saliva seeds (NSS) in ameliorating lead acetate (PbAc)-induced hepatic oxidative damage was investigated using a rabbit model. Forty New Zealand rabbits were given feed and water ad libitum. They were allocated randomly into four groups: control; PbAc (5g/L drinking water); NSS (20g/kg diet) and NSS+PbAc groups. After two months, liver samples were collected and analyzed for malondialdehyde (MDA), glutathione (GSH), glutathione S-transferase (GST) and glutathione peroxidase (GPx) contents...
March 3, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28263310/deficiency-of-the-hepatokine-selenoprotein-p-increases-responsiveness-to-exercise-in-mice-through-upregulation-of-reactive-oxygen-species-and-amp-activated-protein-kinase-in-muscle
#19
Hirofumi Misu, Hiroaki Takayama, Yoshiro Saito, Yuichiro Mita, Akihiro Kikuchi, Kiyo-Aki Ishii, Keita Chikamoto, Takehiro Kanamori, Natsumi Tajima, Fei Lan, Yumie Takeshita, Masao Honda, Mutsumi Tanaka, Seiji Kato, Naoto Matsuyama, Yuya Yoshioka, Kaito Iwayama, Kumpei Tokuyama, Nobuhiko Akazawa, Seiji Maeda, Kazuhiro Takekoshi, Seiichi Matsugo, Noriko Noguchi, Shuichi Kaneko, Toshinari Takamura
Exercise has numerous health-promoting effects in humans; however, individual responsiveness to exercise with regard to endurance or metabolic health differs markedly. This 'exercise resistance' is considered to be congenital, with no evident acquired causative factors. Here we show that the anti-oxidative hepatokine selenoprotein P (SeP) causes exercise resistance through its muscle receptor low-density lipoprotein receptor-related protein 1 (LRP1). SeP-deficient mice showed a 'super-endurance' phenotype after exercise training, as well as enhanced reactive oxygen species (ROS) production, AMP-activated protein kinase (AMPK) phosphorylation and peroxisome proliferative activated receptor γ coactivator (Ppargc)-1α (also known as PGC-1α; encoded by Ppargc1a) expression in skeletal muscle...
April 2017: Nature Medicine
https://www.readbyqxmd.com/read/28251482/analysis-of-the-interactions-between-thioredoxin-and-20-selenoproteins-in-chicken
#20
Qi Liu, Jie Yang, Jingzeng Cai, Yilin Luan, Hamid Sattar, Man Liu, Shiwen Xu, Ziwei Zhang
Thioredoxin (Trx) is a small molecular protein with complicated functions in a number of processes, including inflammation, apoptosis, embryogenesis, cardiovascular disease, and redox regulation. Some selenoproteins, such as glutathione peroxidase (Gpx), iodothyronine deiodinase (Dio), and thioredoxin reductase (TR), are involved in redox regulation. However, whether there are interactions between Trx and selenoproteins is still not known. In the present paper, we used a Modeller, Hex 8.0.0, and the KFC2 Server to predict the interactions between Trx and selenoproteins...
March 2, 2017: Biological Trace Element Research
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