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https://www.readbyqxmd.com/read/26824477/hepatic-macrosteatosis-is-partially-converted-to-microsteatosis-by-melatonin-supplementation-in-ob-ob-mice-non-alcoholic-fatty-liver-disease
#1
Alessandra Stacchiotti, Gaia Favero, Antonio Lavazza, Igor Golic, Marija Aleksic, Aleksandra Korac, Luigi Fabrizio Rodella, Rita Rezzani
BACKGROUND: Obesity is a common risk factor for non-alcoholic fatty liver disease (NAFLD). Currently, there are no specific treatments against NAFLD. Thus, examining any molecule with potential benefits against this condition emerged melatonin as a molecule that influences metabolic dysfunctions. The aim of this study was to determine whether melatonin would function against NAFDL, studying morphological, ultrastuctural and metabolic markers that characterize the liver of ob/ob mice. METHODS: Lean and ob/ob mice were supplemented with melatonin in the drinking water for 8 weeks...
2016: PloS One
https://www.readbyqxmd.com/read/24797780/-relation-of-risk-factors-between-metabolic-syndrome-and-nonalcoholic-fatty-liver-disease-in-children-and-adolescents
#2
Vratislav Smolka, Jiří Ehrmann, Oksana Tkachyk, Martin Zápalka
AIM: In recent years, nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) in children have increased in line with the increased prevalence of obesity. The aim of this retrospective study was to evaluate a relation between NAFDL and MS in children. METHODS: NAFLD was defined as an elevation of serum transaminase level and hyperechogenic feature of liver on ultrasonography. MS definition was based on the diagnostic criteria of the International Diabetes Federation...
2014: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/24263777/assessment-of-the-relationship-between-non-alcoholic-fatty-liver-disease-and-cad-using-msct
#3
Duran Efe, Fatih Aygün
BACKGROUND: Some risk factors for atherosclerosis are followed by non-alcoholic fatty liver disease (NAFLD). We wanted to use Multislice computed tomography (MSCT) as technique for searching relationship between NAFLD and coronary artery disease (CAD). OBJECTIVE: The relationship between NAFLD and CAD was investigated using MSCT. METHODS: A total of 372 individuals with or without cardiac symptoms who had undergone MSCT angiography were included in the study...
January 2014: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/24008607/frequency-of-metabolic-syndrome-and-25-hydroxyvitamin-d3-levels-in-patients-with-non-alcoholic-fatty-liver-disease
#4
S Eraslan, M Kizilgul, M Uzunlulu, Y Colak, O Ozturk, I Tuncer
AIM: It is known that insulin resistance has an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and that serum 25-hidroksivitamin D3 [25-(OH)D] levels are found low in the presence of insulin resistance. Metabolic syndrome (MetS) is characterized by insulin resistance. The purpose of the present study was to determine the levels of 25-(OH)D and the frequency of MetS in patients with NAFLD, and to evaluate the association of 25-(OH)D with the histology of NAFLD and metabolic parameters...
August 2013: Minerva Medica
https://www.readbyqxmd.com/read/22997912/-clinicopathogenetic-characteristics-of-cardiorenal-syndrome-in-non-alcoholic-fatty-liver-disease
#5
M M Severova, E A Saginova, M G Galliamov, N V Ermakov, A V Rodina, V V Fomin, N A Mukhin
AIM: To study clinicopathogenetic characteristics of cardiorenal syndrome (CRS) in non-alcoholic fatty disease of the liver (nAFDL). MATERIAL AND METHODS: Insulin resistance markers, plasma leptin and serum adiponectin concentrations. albuminuria, intima-media thickness (IMT) of the common carotid artery (CCA) were assessed in 80 patients with metabolic syndrome (60 males and 20 females, mean age 44+-11 years) and NAFDL. RESULTS: With increasing signs of affection of target organs in NAFDL there was a trend to a significant rise in detection of chronic kidney disease (CKD) and carotid artery atherosclerosis, aggravation of albuminuria and CCA IMT, lowering of glomerular filtration rate...
2012: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/22990555/association-between-liver-histology-carotid-ultrasonography-and-retinal-vascular-changes-in-patients-with-nonalcoholic-fatty-liver-disease-nafld
#6
Cristina L Băloşeanu, C T Streba, C C Vere, Violeta Comănescu, I Rogoveanu
INTRODUCTION: The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing all over the world. NAFLD has been demonstrated to be associated with carotid artery atherosclerosis, evaluated using the intima-media thickness (IMT). In this article, we focused on the association between NAFLD, carotid parameters such as: intima-media thickness (IMT), pulsatility index (PI) and resistivity index (RI) as markers of subclinical atherosclerosis and the presence of retinal vascular disorders...
2012: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/22964692/-relation-of-non-alcoholic-hepatic-steatosis-to-early-carotid-atherosclerosis-in-diet-controlled-impaired-glucose-tolerance-subjects
#7
RANDOMIZED CONTROLLED TRIAL
A B Pagano, C Vecchio, E Giangreco, S Neri
AIMS: To compare carotid artery intima-media thickness values, as a reliable marker of early atherosclerosis, in individuals with and without nonalcoholic hepatic steatosis, and to evaluate whether such differences are mediate by metabolic syndrome variables. MATERIALS AND METHODS: Carotid intima-media thickness (by ultrasonography), hepatic steatosis (by ultrasonography), insulin resistance (by Homeostasis Model Assessment-HOMA), steatohepatitis (by histologic specimen) were measured in 54 non-alcoholic steatohepatitis, and 54 IGT, compared with 54 healthy subjects...
2012: La Clinica Terapeutica
https://www.readbyqxmd.com/read/22082482/the-emerging-role-of-endocrine-disruptors-in-pathogenesis-of-insulin-resistance-a-concept-implicating-nonalcoholic-fatty-liver-disease
#8
REVIEW
S A Polyzos, J Kountouras, G Deretzi, C Zavos, C S Mantzoros
Endocrine disruptors or endocrine-disrupting chemicals (EDCs) represent a highly heterogeneous group of molecules found in the environment or in consumer products. Toxicology and epidemiology studies have suggested the involvement of diverse EDCs in an increasing number of metabolic disorders, including insulin resistance (IR) and IR-related co morbidities, such as obesity, type 2 diabetes mellitus (T2DM) and polycystic ovary syndrome. Nonalcoholic fatty liver disease (NAFLD), another IR related condition, is emerging as a significant public health concern, affecting 30-45% of the general population in the Western world...
January 2012: Current Molecular Medicine
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