Tatiane de Oliveira Santos, João da Cruz-Filho, Daniely Messias Costa, Raquel Prado da Silva, Hevely Catharine Dos Anjos-Santos, José Ronaldo Dos Santos, Luís Carlos Reis, Ísis do Carmo Kettelhut, Luiz Carlos Navegantes, Enilton Aparecido Camargo, Sandra Lauton-Santos, Daniel Badauê-Passos, André de Souza Mecawi, Danilo Lustrino
Although it has been previously demonstrated that oxytocin (OXT) receptor stimulation can control skeletal muscle mass in vivo, the intracellular mechanisms that mediate this effect are still poorly understood. Thus, rat oxidative skeletal muscles were isolated and incubated with OXT or WAY-267,464, a non-peptide selective OXT receptor (OXTR) agonist, in the presence or absence of atosiban (ATB), an OXTR antagonist, and overall proteolysis was evaluated. The results indicated that both OXT and WAY-267,464 suppressed muscle proteolysis, and this effect was blocked by the addition of ATB...
October 11, 2023: Biochemical Pharmacology