keyword
https://read.qxmd.com/read/38145283/selective-oxytocin-receptor-activation-prevents-prefrontal-circuit-dysfunction-and-social-behavioral-alterations-in-response-to-chronic-prefrontal-cortex-activation-in-male-rats
#21
JOURNAL ARTICLE
Philipp Janz, Frederic Knoflach, Konrad Bleicher, Sara Belli, Barbara Biemans, Patrick Schnider, Martin Ebeling, Christophe Grundschober, Madhurima Benekareddy
INTRODUCTION: Social behavioral changes are a hallmark of several neurodevelopmental and neuropsychiatric conditions, nevertheless the underlying neural substrates of such dysfunction remain poorly understood. Building evidence points to the prefrontal cortex (PFC) as one of the key brain regions that orchestrates social behavior. We used this concept with the aim to develop a translational rat model of social-circuit dysfunction, the chronic PFC activation model (CPA). METHODS: Chemogenetic designer receptor hM3Dq was used to induce chronic activation of the PFC over 10 days, and the behavioral and electrophysiological signatures of prolonged PFC hyperactivity were evaluated...
2023: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/38124130/a-targeted-long-read-sequencing-approach-questions-the-association-of-oxtr-methylation-with-high-functioning-autism
#22
JOURNAL ARTICLE
Jelte Wieting, Kirsten Jahn, Stefan Bleich, Helge Frieling, Maximilian Deest
BACKGROUND: DNA sequence variation and altered epigenetic regulation of the oxytocin receptor gene (OXTR) have been implicated in autism and autistic-like behaviors. While previous studies have examined subsegments of OXTR, nanopore Cas9-targeted sequencing (nCATS) allows deep characterization of entire genes with simultaneous assessment of epigenetic 5-methylcytosine (5mC) modification and without the need for prior DNA amplification or bisulfite conversion. This pilot study uses an nCATS approach to sequence the entire OXTR gene and its regulatory construct and screen for 5mC modification to compare results between individuals with high-functioning autism (HFA) and neurotypical controls (NC)...
December 20, 2023: Clinical Epigenetics
https://read.qxmd.com/read/38110758/parental-psychological-control-the-parent-adolescent-relationship-and-non-suicidal-self-injury-among-chinese-adolescents-the-moderating-effect-of-the-oxytocin-receptor-gene-rs53576-polymorphism
#23
JOURNAL ARTICLE
Huahua Wang, Yuting Deng, Meijin Li, Zhiyuan Tao, Chengfu Yu
Parental psychological control (PPC) is associated with adolescent non-suicidal self-injury (NSSI); however, its underlying mechanisms have not been extensively investigated. Considering that genetic and environmental factors interactively influence adolescent development, this study examined whether the parent-adolescent relationship mediated the link between PPC and adolescent NSSI, and whether this mediating process was moderated by the oxytocin receptor gene rs53576 polymorphism (OXTR rs53576). Participants comprised 673 adolescents (Meanage = 12...
December 18, 2023: Child Psychiatry and Human Development
https://read.qxmd.com/read/38092954/mild-internet-use-is-associated-with-epigenetic-alterations-of-key-neurotransmission-genes-in-salivary-dna-of-young-university-students
#24
JOURNAL ARTICLE
Eugenia Annunzi, Loreta Cannito, Fabio Bellia, Francesca Mercante, Matteo Vismara, Beatrice Benatti, Alberto Di Domenico, Riccardo Palumbo, Walter Adriani, Bernardo Dell'Osso, Claudio D'Addario
The potentially problematic use of the Internet is a growing concern worldwide, which causes and consequences are not completely understood yet. The neurobiology of Internet addiction (IA) has attracted much attention in scientific research, which is now focusing on identifying measurable biological markers. Aim of this study was to investigate epigenetic and genetic regulation of oxytocin receptor (OXTR), dopamine transporter (DAT1) and serotonin transporter (SERT) genes using DNA obtained from saliva samples of young university students: the Internet Addiction Test (IAT) was administered to evaluate the potential existence and intensity of IA...
December 14, 2023: Scientific Reports
https://read.qxmd.com/read/38079518/profiles-of-interferon-stimulated-genes-in-multiple-tissues-and-circulating-pregnancy-associated-glycoproteins-and-their-association-with-pregnancy-loss-in-dairy-cows
#25
JOURNAL ARTICLE
Rafael R Domingues, Joao Paulo N Andrade, Thiago O Cunha, Guilherme Madureira, August S Hoppman, Natalia N Teixeira, Pedro L J Monteiro, Victor H Gomez-Leon, Joao Paulo N Martins, Milo C Wiltbank
Pregnancy loss (PL) in lactating dairy cows disrupts reproductive and productive efficiency. We evaluated the expression of interferon-stimulated genes (ISG) in blood leukocytes, vaginal and cervical epithelial cells, luteolysis-related genes, progesterone and pregnancy-associated glycoproteins (PAG) profiles in lactating dairy cows (n = 86) to gain insight about PL. Expression of ISG on d17, d19, and d21 were greater in cows that maintained the pregnancy (P33) compared to nonpregnant with no PL (NP)...
December 11, 2023: Biology of Reproduction
https://read.qxmd.com/read/38071956/oxytocin-receptor-expressing-neurons-in-the-medial-preoptic-area-are-essential-for-lactation-whereas-those-in-the-lateral-septum-are-not-critical-for-maternal-behavior
#26
JOURNAL ARTICLE
Shizu Hidema, Keisuke Sato, Hiroaki Mizukami, Yumi Takahashi, Yuko Maejima, Kenju Shimomura, Katsuhiko Nishimori
INTRODUCTION: In nurturing systems, the oxytocin (Oxt)-oxytocin receptor (Oxtr) system is important for parturition, and essential for lactation and parental behavior. Among the nerve nuclei that express Oxtr, the lateral septal nucleus (LS) and medial preoptic area (MPOA) are representative regions that control maternal behavior. METHODS: We investigated the role of Oxtr- and Oxtr-expressing neurons, located in the LS and MPOA, in regulating maternal behavior by regulating Oxtr expression in a region-specific manner using recombinant mice and adeno-associated viruses...
December 10, 2023: Neuroendocrinology
https://read.qxmd.com/read/38044379/genome-wide-association-study-for-reproduction-traits-in-colombian-creole-blanco-orejinegro-cattle
#27
JOURNAL ARTICLE
Ana Cristina Herrera Rios, Sindy Liliana Caivio Nasner, Marisol Londoño-Gil, Luis Gabriel Gonzalez-Herrera, Albeiro Lopez-Herrera, Juan Carlos Rincón Flórez
The profitability of the beef cattle production system relies heavily on reproductive traits. Unfortunately, certain traits, such as age at first calving (AFC), calving interval (CI), and gestation length (GL), can pose challenges in traditional breeding programs because of their low heritability (0.01-0.12) and sex-limited characteristics. Another important aspect is the conservation of the genetic resources of animals adapted to the Colombian regions, which implies the preservation and rational use of the creole breeds in the country market...
December 4, 2023: Tropical Animal Health and Production
https://read.qxmd.com/read/38020783/dna-methylation-of-the-oxytocin-receptor-interacts-with-age-to-impact-neural-response-to-social-stimuli
#28
JOURNAL ARTICLE
Meghan H Puglia, Morgan E Lynch, Madelyn G Nance, Jessica J Connelly, James P Morris
INTRODUCTION: Social isolation is one of the strongest predictors of increased risk of mortality in older adulthood. The ability to form and maintain the social relationships that mitigate this risk is partially regulated by the oxytocinergic system and one's ability to attend to and process social information. We have previously shown that an epigenetic change to the DNA of the oxytocin receptor gene ( OXTR methylation) affects the salience of social information in young adults. Little is known about how the oxytocinergic system ages and what effect this aging system has on social cognitive abilities throughout the lifespan...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38013530/relationship-between-genetic-variant-of-oxtr-rs53576-and-mtnr1b-rs1387153-and-symptoms-of-psychological-stress-in-females-with-gestational-diabetes-mellitus
#29
JOURNAL ARTICLE
Fatima Abid, Sadaf Ahmed, Shamoon Noushad, Sabah Farhat, Syeda Sadia Fatima
OBJECTIVE: To assess the association of oxytocin receptor (rs53576) and melatonin hormone receptor 1B (rs1387153) gene single nucleotide polymorphisms with psychological symptoms in women with gestational diabetes mellitus. METHODS: The case-control study was conducted from May 1 to June 1, 2022, at the Department of Physiology, University of Karachi, in collaboration with the Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, and the Department of Obstetrics and Gynaecology, Jinnah Postgraduate Medical Centre, Karachi...
November 2023: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/38003007/assessment-of-the-genetic-characteristics-of-a-generation-born-during-a-long-term-socioeconomic-crisis
#30
JOURNAL ARTICLE
Svetlana V Mikhailova, Dinara E Ivanoshchuk, Pavel S Orlov, Ahmad Bairqdar, Maksim S Anisimenko, Diana V Denisova
BACKGROUND: A socioeconomic crisis in Russia lasted from 1991 to 1998 and was accompanied by a sharp drop in the birth rate. The main factor that influenced the refusal to have children during this period is thought to be prolonged social stress. METHODS: comparing frequencies of common gene variants associated with stress-induced diseases among generations born before, after, and during this crisis may show which genes may be preferred under the pressure of natural selection during periods of increased social stress in urban populations...
November 11, 2023: Genes
https://read.qxmd.com/read/38002996/genomic-signatures-of-positive-selection-in-human-populations-of-the-oxt-oxtr-avp-avpr1a-and-avr1b-gene-variants-related-to-the-regulation-of-psychoemotional-response
#31
JOURNAL ARTICLE
Siroj Yu Bakoev, Anna V Korobeinikova, Arina I Mishina, Shuanat Sh Kabieva, Sergey I Mitrofanov, Alexey A Ivashechkin, Alexsandra I Akinshina, Ekaterina A Snigir, Sergey M Yudin, Vladimir S Yudin, Lyubov V Getmantseva, Elmira A Anderzhanova
The neurobiological systems of maintenance and control of behavioral responses result from natural selection. We have analyzed the selection signatures for single nucleotide variants (SNV) of the genes of oxytocin ( OXT , OXTR ) and vasopressin ( AVP , AVPR1A , AVPR1B ) systems, which are associated with the regulation of social and emotional behavior in distinct populations. The analysis was performed using original WGS (whole genome sequencing) data on Eastern Slavs (SlEast), as well as publicly available data from the 1000 Genomes Project on GBR, FIN, IBR, PUR, BEB, CHB, and ACB populations (the latter were taken as reference)...
November 8, 2023: Genes
https://read.qxmd.com/read/38001957/the-effects-of-age-on-prostatic-responses-to-oxytocin-and-the-effects-of-antagonists
#32
JOURNAL ARTICLE
Masroor Badshah, Jibriil Ibrahim, Nguok Su, Penny Whiley, Michael Whittaker, Betty Exintaris
Benign prostatic hyperplasia (BPH) is an age-related enlargement of the prostate with urethral obstruction that predominantly affects the middle-aged and older male population, resulting in disruptive lower urinary tract symptoms (LUTS), thus creating a profound impact on an individual's quality of life. The development of LUTS may be linked to overexpression of oxytocin receptors (OXTR), resulting in increased baseline myogenic tone within the prostate. Thus, it is hypothesised that targeting OXTR using oxytocin receptor antagonists (atosiban, cligosiban, and β-Mercapto-β,β-cyclopentamethylenepropionyl1, O-Me-Tyr2, Orn8]-Oxytocin (ßMßßC)), may attenuate myogenic tone within the prostate...
November 1, 2023: Biomedicines
https://read.qxmd.com/read/38000191/unraveling-the-mechanisms-of-fenugreek-seed-for-managing-different-gynecological-disorders-steroidal-saponins-and-isoflavones-revealed-as-key-bioactive-metabolites
#33
JOURNAL ARTICLE
Eman Shawky, Rasha A Nassra, Aliaa M T El-Alkamy, Shaimaa M Sallam, Samah M El Sohafy
This study employed network pharmacology-based analysis and reverse molecular docking to investigate the molecular targets and pathways associated with gynecological disorders, particularly those related to steroidal hormones and their receptors, and the potential therapeutic effects of fenugreek (Trigonella foenum-graecum L.) constituents. The STITCH 5.0 database was utilized to identify potential molecular targets, and a compound-target network was constructed. The main targets associated with gynecological disorders included estrogen receptor beta (ESR2), estrogen-related receptor gamma (GPER1), oxytocin receptor (OXTR), progesterone receptor (PGR), prolactin receptor (PRLR), and several enzymes involved in sex hormone biosynthesis...
November 19, 2023: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/37961356/natural-variation-in-oxytocin-receptor-signaling-causes-widespread-changes-in-brain-transcription-a-link-to-the-natural-killer-gene-complex
#34
Arjen J Boender, Zachary V Johnson, George W Gruenhagen, Kengo Horie, Brianna E Hegarty, Jeffrey T Streelman, Hasse Walum, Larry J Young
Oxytocin (OXT) is a highly conserved neuropeptide that modulates social cognition, and variation in its receptor gene ( Oxtr ) is associated with divergent social phenotypes. The cellular mechanisms connecting Oxtr genotype to social phenotype remain obscure. We exploit an association between Oxtr polymorphisms and striatal-specific OXTR density in prairie voles to investigate how OXTR signaling influences the brain transcriptome. We discover widespread, OXTR signaling- dependent transcriptomic changes. Interestingly, OXTR signaling robustly modulates gene expression of C-type lectin-like receptors (CTLRs) in the natural killer gene complex, a genomic region associated with immune function...
October 27, 2023: bioRxiv
https://read.qxmd.com/read/37900160/evidence-for-the-existence-of-facilitatory-interactions-between-the-dopamine-d2-receptor-and-the-oxytocin-receptor-in-the-amygdala-of-the-rat-relevance-for-anxiolytic-actions
#35
JOURNAL ARTICLE
Juan Carlos Hernández-Mondragón, Dexter A Hernández-Hernández, Minerva Crespo-Ramírez, Oscar Prospero-García, Luisa Rocha-Arrieta, Kjell Fuxe, Dasiel O Borroto-Escuela, Miguel Perez de la Mora
Introduction: The amygdala is a limbic region of high value for understanding anxiety and its treatment. Dopamine D2 receptors (D2Rs) and oxytocin receptors (OXTRs) have both been shown to participate in modulating anxiety involving effects in the amygdala. The goal is to understand if D2R-OXTR heterocomplexes exist in the central amygdala and if, through enhancing allosteric receptor-receptor interactions, may enhance anxiolytic actions. Methods: The methods used involve the shock-probe burying test, the in situ proximity ligation assay (PLA), image acquisition and analysis, and the BRET2 assay...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37886970/association-of-oxtr-avpr1a-lnpep-and-cd38-genes-expression-with-the-clinical-presentation-of-autism-spectrum-disorder
#36
JOURNAL ARTICLE
Krzysztof Maria Wilczyński, Aleksandra Auguściak-Duma, Aleksandra Stasik, Lena Cichoń, Alicja Kawalec, Małgorzata Janas-Kozik
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that affects social interactions, communication, and behavior. Although the predominant genetic predisposition to ASD seems beyond doubt, its exact nature remains unclear. In the context of social cognition disorders and the basis of ASD, the oxytocinergic and vasopresynergic systems arouse great interest among researchers. The aim of the present study was to analyze gene expression levels for oxytocin and vasopressin receptors, as well as CD38 protein and oxytocinase, in the context of the clinical picture of autism spectrum disorders...
October 16, 2023: Current Issues in Molecular Biology
https://read.qxmd.com/read/37870496/clustering-of-multi-tissue-transcriptomes-in-gilts-with-normal-cyclicity-or-delayed-puberty-reveals-genes-related-to-pubertal-development
#37
JOURNAL ARTICLE
Hiruni R Wijesena, Brittney N Keel, Dan J Nonneman, Robert A Cushman, Clay A Lents
In gilts, puberty is marked by standing estrus in the presence of a boar. Delayed puberty (failure to display pubertal estrus) is a major reason for gilt removal. To investigate the physiological determinants underlying delayed puberty in gilts, transcriptomic data from tissues relevant to estrus and puberty, such as mediobasal hypothalamus, anterior pituitary gland, ovarian cortex, olfactory bulb, amygdala, and hippocampus were obtained from age-matched delayed puberty (n = 8) and cyclic control gilts at follicular phase (n = 8) and luteal phase (n = 8) of the estrous cycle...
October 23, 2023: Biology of Reproduction
https://read.qxmd.com/read/37832795/non-canonical-ca-2-akt-signaling-pathway-mediates-the-antiproteolytic-effects-induced-by-oxytocin-receptor-stimulation-in-skeletal-muscle
#38
JOURNAL ARTICLE
Tatiane de Oliveira Santos, João da Cruz-Filho, Daniely Messias Costa, Raquel Prado da Silva, Hevely Catharine Dos Anjos-Santos, José Ronaldo Dos Santos, Luís Carlos Reis, Ísis do Carmo Kettelhut, Luiz Carlos Navegantes, Enilton Aparecido Camargo, Sandra Lauton-Santos, Daniel Badauê-Passos, André de Souza Mecawi, Danilo Lustrino
Although it has been previously demonstrated that oxytocin (OXT) receptor stimulation can control skeletal muscle mass in vivo, the intracellular mechanisms that mediate this effect are still poorly understood. Thus, rat oxidative skeletal muscles were isolated and incubated with OXT or WAY-267,464, a non-peptide selective OXT receptor (OXTR) agonist, in the presence or absence of atosiban (ATB), an OXTR antagonist, and overall proteolysis was evaluated. The results indicated that both OXT and WAY-267,464 suppressed muscle proteolysis, and this effect was blocked by the addition of ATB...
October 11, 2023: Biochemical Pharmacology
https://read.qxmd.com/read/37806189/lack-of-evidence-for-coevolution-between-oxytocin-receptor-n-terminal-variants-and-monogamy-in-placental-mammals
#39
JOURNAL ARTICLE
Paola Cerrito, Jeffrey K Spear
Oxytocin (OXT) is a neurohypophyseal hormone that influences a wide range of affiliative behaviors, such as pair-bonding and infant care, across mammals. The effects of OXT depend significantly on an adequate interaction with its receptor, OXTR. OXTR belongs to the G-protein coupled receptor family. The extracellular N-terminal domain of OXTR interacts with the linear C-terminal tail of OXT and is required for OXT binding. Across mammalian species there is a genetic diversity in OXTR terminal sequence. Previous work on primates has shown an association between OXTR phylogeny and monogamy...
October 6, 2023: Hormones and Behavior
https://read.qxmd.com/read/37800217/genetic-contributors-to-ptsd-the-role-of-snvs-gene-interactions-and-haplotypes-for-developing-ptsd-prevention-measures-a-comprehensive-review
#40
JOURNAL ARTICLE
Alexey Kuznetsov, Daniil Kokorev, Alexey Sustretov, Andrey Kozlov, Artem Lyamin, Mikhail Sheyfer, Aleksandr Kolsanov, Avinash DeSousa, Paul Cumming, Arseny Gayduk
BACKGROUND: Post-traumatic stress disorder (PTSD) is a trauma- or stressor-related mental health condition with high socioeconomic burden. We aimed in this review to identify promising genetic markers predisposing for PTSD, which might serve in the design subsequent studies aiming to develop PTSD prevention and remediation measures. SUBJECTS AND METHODS: Our search queries in the PubMed database yielded 547 articles, of which 20 met our inclusion criteria for further analysis: published between 2018 and 2022, original research, containing molecular-genetic and statistical data, containing diagnosis verification methods, PTSD as a primary condition, and a sample of at least 60 patients...
October 2023: Psychiatria Danubina
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