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https://www.readbyqxmd.com/read/27903255/epigenetic-evidence-for-involvement-of-the-oxytocin-receptor-gene-in-obsessive-compulsive-disorder
#1
Carolina Cappi, Juliana Belo Diniz, Guaraci L Requena, Tiaya Lourenço, Bianca Cristina Garcia Lisboa, Marcelo Camargo Batistuzzo, Andrea H Marques, Marcelo Q Hoexter, Carlos A Pereira, Euripedes Constantino Miguel, Helena Brentani
BACKGROUND: Obsessive-compulsive disorder (OCD) is a chronic neurodevelopmental disorder that affects up to 3% of the general population. Although epigenetic mechanisms play a role in neurodevelopment disorders, epigenetic pathways associated with OCD have rarely been investigated. Oxytocin is a neuropeptide involved in neurobehavioral functions. Oxytocin has been shown to be associated with the regulation of complex socio-cognitive processes such as attachment, social exploration, and social recognition, as well as anxiety and other stress-related behaviors...
November 30, 2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27872764/genetic-regulation-of-maternal-oxytocin-response-and-its-influences-on-maternal-behavior
#2
Divya Mehta, Valsamma Eapen, Jane Kohlhoff, Antonio Mendoza Diaz, Bryanne Barnett, Derrick Silove, Mark R Dadds
We interrogated the genetic modulation of maternal oxytocin response and its association with maternal behavior using genetic risk scores within the oxytocin receptor (OXTR) gene. We identified a novel SNP, rs968389, to be significantly associated with maternal oxytocin response after a challenging mother-infant interaction task (Still Face Paradigm) and maternal separation anxiety from the infant. Performing a multiallelic analysis across OXTR by calculating a cumulative genetic risk score revealed a significant gene-by-environment (G × E) interaction, with OXTR genetic risk score interacting with adult separation anxiety to modulate levels of maternal sensitivity...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27871902/the-effects-of-long-term-estradiol-treatment-on-social-behavior-and-gene-expression-in-adult-female-rats
#3
Alexandra N Garcia, Kelsey Bezner, Christina Depena, Weiling Yin, Andrea C Gore
This study tested the effects of long-term estradiol (E2) replacement on social behavior and gene expression in brain nuclei involved in the regulation of these social behaviors in adult female rats. We developed an ultrasonic vocalization (USV) test and a sociability test to examine communications, social interactions, and social preference, using young adult female cagemates. All rats were ovariectomized (OVX) and implanted with a Silastic capsule containing E2 or vehicle, and housed in same-treatment pairs for a 3-month period...
November 18, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27867940/oxytocin-receptor-oxtr-methylation-and-cognition-in-psychotic-disorders
#4
Tyler B Grove, Kyle J Burghardt, A Zarina Kraal, Ryan J Dougherty, Stephan F Taylor, Vicki L Ellingrod
Previous reports have identified an association between cognitive impairment and genetic variation in psychotic disorders. In particular, this association may be related to abnormal regulation of genes responsible for broad cognitive functions such as the oxytocin receptor (OXTR). Within psychotic disorders, it is unknown if OXTR methylation, which can have important implications for gene regulation, is related to cognitive function. The current study examined peripheral blood OXTR methylation and general cognition in people with schizophrenia, schizoaffective disorder, and psychotic disorder not otherwise specified (N = 101)...
October 2016: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/27860243/lessons-from-the-canine-oxtr-gene-populations-variants-and-functional-aspects
#5
Melinda Bence, Peter Marx, Eszter Szantai, Eniko Kubinyi, Zsolt Ronai, Zsofia Banlaki
Oxytocin receptor (OXTR) acts as a key behavioral modulator of the central nervous system, affecting social behavior, stress, affiliation and cognitive functions. Variants of the Oxtr gene are known to influence behavior both in animals and humans, however, canine Oxtr polymorphisms are less characterized in terms of possible relevance to function, selection criteria in breeding and domestication. In this report, we provide a detailed characterization of common variants of the canine Oxtr gene. In particular, (1) novel polymorphisms were identified by direct sequencing of wolf and dog samples, (2) allelic distributions and pairwise linkage disequilibrium patterns of several canine populations were compared, (3) neighbor joining tree based on common SNPs was constructed, (4) mRNA expression features were assessed, (5) a novel splice variant was detected and (6) in vitro functional assays were performed...
November 11, 2016: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27857161/gene-expression-profiling-of-breast-cancer-in-lebanese-women
#6
Joelle Makoukji, Nadine J Makhoul, Maya Khalil, Sally El-Sitt, Ehab Saad Aldin, Mark Jabbour, Fouad Boulos, Emanuela Gadaleta, Ajanthah Sangaralingam, Claude Chelala, Rose-Mary Boustany, Arafat Tfayli
Breast cancer is commonest cancer in women worldwide. Elucidation of underlying biology and molecular pathways is necessary for improving therapeutic options and clinical outcomes. Molecular alterations in breast cancer are complex and involve cross-talk between multiple signaling pathways. The aim of this study is to extract a unique mRNA fingerprint of breast cancer in Lebanese women using microarray technologies. Gene-expression profiles of 94 fresh breast tissue samples (84 cancerous/10 non-tumor adjacent samples) were analyzed using GeneChip Human Genome U133 Plus 2...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27852134/further-evidence-of-the-limited-role-of-candidate-genes-in-relation-to-infant-mother-attachment-outcomes
#7
Esther M Leerkes, Lindsey R Gedaly, Nan Zhou, Susan Calkins, Vincent C Henrich, Andrew Smolen
In this paper, we examine the associations between specific candidate genes (DRD2, DRD4, COMT, biallelic and tri-allelic 5HTTLPR, and OXTR) and infant attachment outcomes as main effects and in conjunction with maternal sensitivity. The sample included 200 infants (97 European American, 94 African-American, and 9 biracial) and their mothers. Maternal sensitivity and overtly negative maternal behavior were observed when infants were 6 months and 1 year old in distress-eliciting contexts, attachment was assessed via the Strange Situation at age 1, and DNA samples were collected when children were 2 years old...
November 16, 2016: Attachment & Human Development
https://www.readbyqxmd.com/read/27843152/additive-effects-of-oxytocin-receptor-gene-polymorphisms-on-reward-circuitry-in-youth-with-autism
#8
L M Hernandez, K Krasileva, S A Green, L E Sherman, C Ponting, R McCarron, J K Lowe, D H Geschwind, S Y Bookheimer, M Dapretto
Several common alleles in the oxytocin receptor gene (OXTR) are associated with altered brain function in reward circuitry in neurotypical adults and may increase risk for autism spectrum disorders (ASD). Yet, it is currently unknown how variation in the OXTR relates to brain functioning in individuals with ASD, and, critically, whether neural endophenotypes vary as a function of aggregate genetic risk. Here, for we believe the first time, we use a multi-locus approach to examine how genetic variation across several OXTR single-nucleotide polymorphisms (SNPs) affect functional connectivity of the brain's reward network...
November 15, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27837182/the-oxytocin-receptor-gene-oxtr-and-face-recognition
#9
Roeland J Verhallen, Jenny M Bosten, Patrick T Goodbourn, Adam J Lawrance-Owen, Gary Bargary, J D Mollon
A recent study has linked individual differences in face recognition to rs237887, a single-nucleotide polymorphism (SNP) of the oxytocin receptor gene (OXTR; Skuse et al., 2014). In that study, participants were assessed using the Warrington Recognition Memory Test for Faces, but performance on Warrington's test has been shown not to rely purely on face recognition processes. We administered the widely used Cambridge Face Memory Test-a purer test of face recognition-to 370 participants. Performance was not significantly associated with rs237887, with 16 other SNPs of OXTR that we genotyped, or with a further 75 imputed SNPs...
November 11, 2016: Psychological Science
https://www.readbyqxmd.com/read/27818356/association-between-oxytocin-and-receptor-genetic-polymorphisms-and-aggression-in-a-northern-chinese-han-population-with-alcohol-dependence
#10
Ling Yang, Fan Wang, Meiling Wang, Mei Han, Lufeng Hu, Minghua Zheng, Ji Ma, Yimin Kang, Pengxiang Wang, Hongqiang Sun, Wei Zuo, Longteng Xie, Aiju Wang, Dongsheng Yu, Yanlong Liu
OBJECTIVE: Alcohol dependence (AD) is a common chronic brain disorder precipitated by complex interactions between biological, genetic, and environmental risk factors. Aggression often occurs in the context of AD. Previous studies have shown that Oxytocin (OXT) and OXT receptor (OXTR) are involved in the regulation of aggression. The present study investigated whether variations and interactions of OXT and OXTR genes were associated with AD-related aggression in a genetically homogeneous northern Chinese Han population...
November 3, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27798253/oxytocin-receptor-gene-variations-predict-neural-and-behavioral-response-to-oxytocin-in-autism
#11
Takamitsu Watanabe, Takeshi Otowa, Osamu Abe, Hitoshi Kuwabara, Yuta Aoki, Tatsunobu Natsubori, Hidemasa Takao, Chihiro Kakiuchi, Kenji Kondo, Masashi Ikeda, Nakao Iwata, Kiyoto Kasai, Tsukasa Sasaki, Hidenori Yamasue
Oxytocin appears beneficial for autism spectrum disorder (ASD), and more than 20 single-nucleotide polymorphisms (SNPs) in oxytocin receptor (OXTR) are relevant to ASD. However, neither biological functions of OXTR SNPs in ASD nor critical OXTR SNPs that determine oxytocin's effects on ASD remain unknown. Here, using a machine-learning algorithm that was designed to evaluate collective effects of multiple SNPs and automatically identify most informative SNPs, we examined relationships between 27 representative OXTR SNPs and six types of behavioral/neural response to oxytocin in ASD individuals...
October 19, 2016: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/27790153/nerve-growth-factor-brain-derived-neurotrophic-factor-and-osteocalcin-gene-relationship-in-energy-regulation-bone-homeostasis-and-reproductive-organs-analyzed-by-mrna-quantitative-evaluation-and-linear-correlation-analysis
#12
Claudia Camerino, Elena Conte, Maria Cannone, Roberta Caloiero, Adriano Fonzino, Domenico Tricarico
Nerve Growth Factor (NGF)/Brain-derived Neurotrophic Factor (BDNF) and osteocalcin share common effects regulating energy, bone mass, reproduction and neuronal functions. To investigate on the gene-relationship between NGF, BDNF, and Osteocalcin we compared by RT-PCR the transcript levels of Ngf, Bdnf and Osteocalcin as well as of their receptors p75NTR/NTRK1, NTRK2, and Gprc6a in brain, bone, white/brown adipose tissue (WAT/BAT) and reproductive organs of 3 months old female and male mice. Brain and bone were used as positive controls for NGF/BDNF and Osteocalcin respectively...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27773348/endometrial-prostaglandin-synthases-ovarian-steroids-and-oxytocin-receptors-in-mares-with-oxytocin-induced-luteal-maintenance
#13
Maria R Rebordão, António Galvão, Pedro Pinto-Bravo, Joana Pinheiro, Sandra Gamboa, Elisabete Silva, Luísa Mateus, Graça Ferreira-Dias
Oxytocin (OXT) has been used to prolong the luteal phase in mares, but its mechanism of action is unknown. The aim of this study was to evaluate the effect of chronic exogenous OXT administration to mid-luteal phase mares on luteal maintenance. Also, endometrial expression of prostaglandin endoperoxide synthase 2 (PTGS2), prostaglandin F2α, E2 and I2 synthases (AKR1C3, PTGES, and PTGIS), oxytocin receptor (OXTR), progesterone receptor (PGR), and estrogen receptors 1 (ESR1) and 2 (ESR2) were assessed in mares experiencing luteal maintenance 2 weeks after chronic exogenous OXT administration...
September 8, 2016: Theriogenology
https://www.readbyqxmd.com/read/27743766/genetic-variants-in-oxytocin-receptor-and-arginine-vasopressin-receptor-1a-are-associated-with-the-neural-correlates-of-maternal-and-paternal-affection-towards-their-child
#14
Shota Nishitani, Kazuya Ikematsu, Tsunehiko Takamura, Sumihisa Honda, Koh-Ichiro Yoshiura, Kazuyuki Shinohara
There is extensive evidence in animal studies, particularly in vole species (Microtus), that oxytocin (OT) receptor and arginine-vasopressin (AVP) receptor 1a is critical for the regulation of maternal and paternal behavior, respectively. Human studies have gained insight into the relationship between both hormone receptor gene variants and behavior, but not between the variants and the underlying brain activity. To study this, we investigated the association between neural activation of the anterior prefrontal cortex (APFC) in mothers and fathers in response to their child smiling video stimuli to induce the positive affect related to attachment with their child, and genetic variants of OT receptor (OXTR) and AVP receptor 1A (AVPR1A)...
October 13, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27717050/transient-and-persistent-behavioral-and-molecular-changes-in-primiparous-female-wistar-rats
#15
Roshan R Naik, Trynke R de Jong
Motherhood brings about a multitude of behavioral and physiological changes in dams and some of these persist until after weaning. We studied behavioral changes associated with reproductive experience at lactating day (LD)8, at weaning (LD21), and 28 days post-weaning (PW28) compared to nulliparous (NP) females. Furthermore, in another cohort of animals, we quantified mRNA expression of five target genes known to be associated with maternal experience: arginin-vasopressin(Avp) and its 1A receptor(Avpr1a), oxytocin(Oxt) and its receptor(Oxtr), and corticotropin-releasing hormone(Crh) in three key maternal region: the medial preoptic area (MPOA), bed nucleus of the stria terminalis (BNST) and paraventricular hypothalamic nucleus(PVN)...
September 26, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27716573/oxytocin-receptor-gene-variation-rs53576-and-alcohol-abuse-in-a-longitudinal-population-representative-study
#16
Mariliis Vaht, Triin Kurrikoff, Kariina Laas, Toomas Veidebaum, Jaanus Harro
BACKGROUND: Oxytocin is an important regulator of social relationships and has been implicated in development of substance use and addiction. We examined the association of a variance in the oxytocin receptor gene (OXTR rs53576 polymorphism) with alcohol use in a population-representative sample, and potential moderation by social functioning. METHODS: The analysis was carried out on the older birth cohort of the longitudinal Estonian Children Personality Behaviour and Health Study (ECPBHS), a cohort of initially 15 years old children (original n=593) recalled at ages 18 and 25...
September 25, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27713694/variation-in-the-oxytocin-receptor-gene-is-associated-with-face-recognition-and-its-neural-correlates
#17
Lars Westberg, Susanne Henningsson, Anna Zettergren, Joakim Svärd, Daniel Hovey, Tian Lin, Natalie C Ebner, Håkan Fischer
The ability to recognize faces is crucial for daily social interactions. Recent studies suggest that intranasal oxytocin administration improves social recognition in humans. Oxytocin signaling in the amygdala plays an essential role for social recognition in mice, and oxytocin administration has been shown to influence amygdala activity in humans. It is therefore possible that the effects of oxytocin on human social recognition depend on mechanisms that take place in the amygdala-a central region for memory processing also in humans...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27693815/congenital-prosopagnosia-is-associated-with-a-genetic-variation-in-the-oxytocin-receptor-oxtr-gene-an-exploratory-study
#18
Zaira Cattaneo, Roberta Daini, Manuela Malaspina, Federico Manai, Mariarita Lillo, Valentina Fermi, Susanna Schiavi, Boris Suchan, Sergio Comincini
Face-recognition deficits, referred to with the term prosopagnosia (i.e., face blindness), may manifest during development in the absence of any brain injury (from here the term congenital prosopagnosia, CP). It has been estimated that approximately 2.5% of the population is affected by face-processing deficits not depending on brain lesions, and varying a lot in severity. The genetic bases of this disorder are not known. In this study we tested for genetic association between single-nucleotide polymorphisms (SNPs) in the oxytocin receptor gene (OXTR) and CP in a restricted cohort of Italian participants...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27692350/-epigenetics-implication-in-autism-spectrum-disorders-a-review
#19
M Hamza, S Halayem, R Mrad, S Bourgou, F Charfi, A Belhadj
BACKGROUND: The etiology of autism spectrum disorders (ASD) is complex and multifactorial, and the roles of genetic and environmental factors in its emergence have been well documented. Current research tends to indicate that these two factors act in a synergistic manner. The processes underlying this interaction are still poorly known, but epigenetic modifications could be the mediator in the gene/environment interface. The epigenetic mechanisms have been implicated in susceptibility to stress and also in the pathogenesis of psychiatric disorders including depression and schizophrenia...
September 27, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27641503/a-cortical-circuit-for-sexually-dimorphic-oxytocin-dependent-anxiety-behaviors
#20
Kun Li, Miho Nakajima, Ines Ibañez-Tallon, Nathaniel Heintz
The frequency of human social and emotional disorders varies significantly between males and females. We have recently reported that oxytocin receptor interneurons (OxtrINs) modulate female sociosexual behavior. Here, we show that, in male mice, OxtrINs regulate anxiety-related behaviors. We demonstrate that corticotropin-releasing-hormone-binding protein (CRHBP), an antagonist of the stress hormone CRH, is specifically expressed in OxtrINs. Production of CRHBP blocks the CRH-induced potentiation of postsynaptic layer 2/3 pyramidal cell activity of male, but not female, mice, thus producing an anxiolytic effect...
September 22, 2016: Cell
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