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https://www.readbyqxmd.com/read/28918249/perinatal-depression-and-dna-methylation-of-oxytocin-related-genes-a-study-of-mothers-and-their-children
#1
Leonora King, Stephanie Robins, Gang Chen, Volodymyr Yerko, Yi Zhou, Corina Nagy, Nancy Feeley, Ian Gold, Barbara Hayton, Gustavo Turecki, Phyllis Zelkowitz
The present study investigated the association of perinatal depression (PD) with differential methylation of 3 genomic regions among mother and child dyads: exon 3 within the oxytocin receptor (OXTR) gene and 2 intergenic regions (IGR) between the oxytocin (OXT) and vasopressin (AVP) genes. Maternal PD was assessed at 5 time-points during pregnancy and postpartum. Four groups were established based on Edinburgh Postnatal Depression Scale (EPDS) cut-off scores: no PD, prenatal or postpartum depressive symptoms only and persistent PD (depressive symptoms both prenatally and postpartum)...
September 13, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28915380/oxytocin-receptor-gene-polymorphisms-exert-a-modulating-effect-on-the-onset-age-in-patients-with-obsessive-compulsive-disorder
#2
Jee In Kang, Hae Won Kim, Chul Hoon Kim, Eun Hee Hwang, Se Joo Kim
The oxytocin receptor (OXTR) is a potential candidate in the pathophysiology of obsessive-compulsive disorder (OCD). The present study investigated the association between common single-nucleotide polymorphism (SNPs) of the OXTR gene and the affected status of OCD or distinct clinical subtypes of OCD including the age at onset and symptom dimensions. Ten SNPs of OXTR were examined in 615 patients with OCD and 581 healthy controls. Single-marker and haplotype-based association analyses were conducted. While OXTR variants were not associated with the affected status of OCD or its clinical symptom dimensions, rs2268493 (p=0...
September 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28912494/oxytocin-receptor-polymorphisms-are-differentially-associated-with-social-abilities-across-neurodevelopmental-disorders
#3
Danielle A Baribeau, Annie Dupuis, Tara A Paton, Stephen W Scherer, Russell J Schachar, Paul D Arnold, Peter Szatmari, Rob Nicolson, Stelios Georgiades, Jennifer Crosbie, Jessica Brian, Alana Iaboni, Jason Lerch, Evdokia Anagnostou
Oxytocin is a pituitary neuropeptide that affects social behaviour. Single nucleotide polymorphisms (SNPs) in the oxytocin receptor gene (OXTR) have been shown to explain some variability in social abilities in control populations. Whether these variants similarly contribute to the severity of social deficits experienced by children with neurodevelopmental disorders is unclear. Social abilities were assessed in a group of children with autism spectrum disorder (ASD, n = 341) or attention deficit hyperactivity disorder (ADHD, n = 276) using two established social measures...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911267/the-behavioral-and-molecular-evaluation-of-effects-of-social-instability-stress-as-a-model-of-stress-related-disorders-in-adult-female-rats
#4
Marta Maria Nowacka-Chmielewska, Daniela Kasprowska-Liśkiewicz, Jarosław Jerzy Barski, Ewa Obuchowicz, Andrzej Małecki
The study aimed to test the hypotheses that chronic social instability stress (CSIS) alters behavioral and physiological parameters and expression of selected genes important for stress response and social behaviors. Adult female Sprague-Dawley rats were subjected to the 4-week CSIS procedure, which involves unpredictable rotation between phases of isolation and overcrowding. Behavioral analyses (Experiment 1) were performed on the same rats before and after CSIS (n = 16) and physiological and biochemical measurements (Experiment 2) were made on further control (CON; n = 7) and stressed groups (CSIS; n = 8)...
September 15, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28890000/maternal-drd2-slc6a3-and-oxtr-genotypes-as-potential-moderators-of-the-relation-between-maternal-history-of-care-and-maternal-cortisol-secretion-in-the-context-of-mother-infant-separation
#5
Jaclyn A Ludmer, Brittany Jamieson, Andrea Gonzalez, Robert Levitan, James Kennedy, Vanessa Villani, Mario Masellis, Vincenzo S Basile, Leslie Atkinson
A mother's cortisol secretion is importantly associated with her own mental health and her infant's cortisol secretion. This study investigated the influences of maternal history of care and maternal DRD2, SLC6A3, and OXTR genotypes on maternal cortisol in the context of infant stress. A community sample of 296 mother-infant dyads completed a maternal separation at infant age 17 months. Maternal salivary cortisol, buccal cells, and self-reported history of care were collected. Multilevel models revealed that history of care had a greater influence on maternal baseline cortisol (but not cortisol trajectory) for mothers with more plasticity alleles of SLC6A3 (10R) and OXTR (G), relative to mothers with fewer or no plasticity alleles...
September 7, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28868757/depression-in-early-adolescence-contributions-from-relational-aggression-and-variation-in-the-oxytocin-receptor-gene
#6
Shauna C Kushner, Kathrin Herzhoff, Suzanne Vrshek-Schallhorn, Jennifer L Tackett
Interpersonal stress arising from relational aggression (RA)-the intentional effort to harm others via rejection and exclusion-may increase risk for depression in youth. Biological vulnerabilities related to the hormone oxytocin, which affects social behavior and stress responses, may exacerbate this risk. In a community sample of 307 youth (52% female; age range = 10-14 years), we tested whether (1) the association between RA and subsequent depressive symptoms was mediated through social problems and (2) a single nucleotide polymorphism (rs53576) in the oxytocin receptor gene (OXTR) moderated this indirect association between RA and depression, where GG homozygotes are predicted to be more sensitive to the effects of social problems than A-allele carriers...
September 4, 2017: Aggressive Behavior
https://www.readbyqxmd.com/read/28865941/a-field-study-of-the-association-between-cd38-gene-and-altruistic-behavior-empathic-response-as-a-mediator
#7
Jinting Liu, Pingyuan Gong, Hong Li, Xiaolin Zhou
Inspired by the enhancement effects of oxytocin on empathic responses and altruistic behaviors, we conducted a field study with a real fundraising event and investigated to what extent oxytocin pathway genes (CD38 and OXTR) modulate individual differences in charitable donation. Participants were informed that a teacher in their university was diagnosed with uremia and could not afford the cost of medication. They were given the opportunity to donate any amount of money and report their empathic responses to the misfortune of the teacher...
August 12, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28865405/the-role-of-stress-regulation-genes-in-moderating-the-association-of-stress-and-daily-life-psychotic-experiences
#8
P Cristóbal-Narváez, T Sheinbaum, I Myin-Germeys, T R Kwapil, M de Castro-Catala, T Domínguez-Martínez, A Racioppi, M Monsonet, L Hinojosa-Marqués, R van Winkel, A Rosa, N Barrantes-Vidal
OBJECTIVE: The interaction of single nucleotide polymorphisms with both distal and proximal environmental factors across the extended psychosis phenotype is understudied. This study examined (i) the interaction of relevant SNPs with both early-life adversity and proximal (momentary) stress on psychotic experiences (PEs) in an extended psychosis sample; and (ii) differences between early-psychosis and non-clinical groups for these interactions. METHODS: Two hundred and forty-two non-clinical and 96 early-psychosis participants were prompted randomly eight times daily for 1 week to complete assessments of current experiences, including PEs and stress...
September 2, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28815558/sequence-variants-in-esr1-and-oxtr-are-associated-with-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome
#9
Sara Yvonne Brucker, Liliane Frank, Simone Eisenbeis, Melanie Henes, Diethelm Wallwiener, Olaf Riess, Barbara Van Eijck, Dorit Schöller, Michael Bonin, Kristin Katharina Rall
INTRODUCTION: Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is characterized by congenital absence of the uterus and the upper two-thirds of the vagina in otherwise phenotypically normal females. It is found isolated or associated with renal, skeletal and other malformations. Despite of ongoing research, the etiology is mainly unknown. For a long time, the hypothesis of deficient hormone receptors as cause for MRKHS exists, and is supported by previous findings of our group. The aim of the present study was to identify unknown genetic causes for MRKHS and to compare them with data banks including a review of the literature...
August 16, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28812274/oxytocin-and-anxiety-disorders
#10
Michael G Gottschalk, Katharina Domschke
In the present chapter, we review the literature focusing on oxytocin (OT)-centered research in anxiety spectrum conditions, comprising separation anxiety disorder, specific phobias, social anxiety disorder (SAD), panic disorder, generalized anxiety disorder, and anxiety-related endophenotypes (e.g., trust behavior, behavioral inhibition, neuroticism, and state/trait anxiety). OT receptor gene (OXTR) polymorphisms have been implicated in gene-environment interactions with attachment style and childhood maltreatment and to influence clinical outcomes, including SAD intensity and limbic responsiveness...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28770970/oxtr-and-zeb1-expression-before-and-after-progesterone-dosing-in-pregnant-women-with-threatened-premature-labor
#11
Y-J Xu, L-D Ren, S-S Zhai, L-M Ran, L-L Hu, X-H Luo, T Hong, R Liu, Y-R Yu, Y-J Ban
OBJECTIVE: To investigate changes in the peripheral blood mRNA levels of oxytocin receptor (OXTR) and Zinc finger E-box-binding homeobox 1 (ZEB1) before and after progesterone dosing in pregnant women with threatened premature labor. PATIENTS AND METHODS: Blood samples were collected from 30 healthy pregnant women with 28- to 33+6-week gestational age and singleton pregnancy (group A) and from 30 pregnant women with singleton pregnancy and threatened premature labor before and 48 hours after progesterone dosing (groups B and C, respectively) for quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) assay to assess the OXTR and ZEB1 mRNA levels...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28765081/intranasal-oxytocin-and-a-polymorphism-in-the-oxytocin-receptor-gene-are-associated-with-human-directed-social-behavior-in-golden-retriever-dogs
#12
Mia E Persson, Agaia J Trottier, Johan Bélteky, Lina S V Roth, Per Jensen
The oxytocin system may play an important role in dog domestication from the wolf. Dogs have evolved unique human analogue social skills enabling them to communicate and cooperate efficiently with people. Genomic differences in the region surrounding the oxytocin receptor (OXTR) gene have previously been associated with variation in dogs' communicative skills. Here we have utilized the unsolvable problem paradigm to investigate the effects of oxytocin and OXTR polymorphisms on human-directed contact seeking behavior in 60 golden retriever dogs...
August 17, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28755420/cytobrush-a-tool-for-sequential-evaluation-of-gene-expression-in-bovine-endometrium
#13
B Cardoso, M L Oliveira, G Pugliesi, Eos Batista, M Binelli
Aims were to (i) compare specific transcript abundance between endometrial samples collected by transcervical biopsy and cytobrush and (ii) measure the abundance of endometrial transcripts involved in PGF2α synthesis in samples collected by cytobrush. In Experiment 1, endometrial samples were taken transcervically by cytobrush and biopsy 10 days after ovulation. Compared to biopsy samples, abundance of transcripts for MSTN, AKR1C4 and PGR was similar, VIM, FLT1 and PTGES was lower (p < .05) and KRT18 and CD3D was greater in cytobrush samples (p < ...
July 28, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28753494/ovarian-steroids-oxytocin-and-tumor-necrosis-factor-modulate-equine-oviduct-function
#14
P Pinto-Bravo, A Galvão, M R Rebordão, A Amaral, D Ramilo, E Silva, A Szóstek-Mioduchowska, G Alexandre-Pires, R Roberto da Costa, D J Skarzynski, G Ferreira-Dias
The oviduct plays important roles in the early reproductive process. The aim of this study was to evaluate gene transcription and protein expression of progesterone receptor (PGR), estrogen receptors 1 (ESR1) and 2 (ESR2); oxytocin receptor (OXTR); prostaglandin F2α synthase (AKR1C3), and prostaglandin E2 synthase (Ptges) in mare oviduct in different estrous cycle stages. Estradiol (E2), progesterone (P4), oxytocin (OXT), and tumor necrosis factor α (TNF) effect on in vitro PGE2 and prostaglandin F2α (PGF2α) secretion by equine oviduct explants or by oviductal epithelial cells (OECs) were also assessed...
June 24, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28748210/dataset-on-genetic-and-physiological-adults-responses-to-social-distress
#15
Andrea Bonassi, Tommaso Ghilardi, Anna Truzzi, Ilaria Cataldo, Atiqah Azhari, Peipei Setoh, Kazuyuki Shinohara, Gianluca Esposito
Both expectations towards interactions with conspecifics, and genetic predispositions, affect adults׳ social behaviors. However, the underlying mechanisms remain largely unknown. Here, we report data to investigate the interaction between genetic factors, (oxytocin receptor (OXTR) and serotonin transporter (5-HTTLPR) polymorphisms), and adult interactional patterns in shaping physiological responses to social distress. During the presentation of distress vocalizations (cries of human female, infants and bonobos) we assessed participants׳ (N = 42 males) heart rate (HR) and peripheral nose temperature, which index state of arousal and readiness to action...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28715704/oxytocin-receptor-gene-polymorphisms-attachment-and-ptsd-results-from-the-national-health-and-resilience-in-veterans-study
#16
Lauren M Sippel, Shizhong Han, Laura E Watkins, Ilan Harpaz-Rotem, Steven M Southwick, John H Krystal, Miranda Olff, Richard Sherva, Lindsay A Farrer, Henry R Kranzler, Joel Gelernter, Robert H Pietrzak
The human oxytocin system is implicated in social behavior and stress recovery. Polymorphisms in the oxytocin receptor gene (OXTR) may interact with attachment style to predict stress-related psychopathology like posttraumatic stress disorder (PTSD). The objective of this study was to examine independent and interactive effects of the OXTR single nucleotide polymorphism (SNP) rs53576, which has been associated with stress reactivity, support-seeking, and PTSD in prior studies, and attachment style on risk for PTSD in a nationally representative sample of 2163 European-American (EA) U...
November 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28694300/the-regulation-of-oxytocin-and-oxytocin-receptor-in-human-placenta-according-to-gestational-age
#17
Seung Chul Kim, Jae-Eon Lee, Seong Soo Kang, Hoe-Saeng Yang, Sun Suk Kim, Beum-Soo An
Oxytocin (OXT) is a peptide hormone that plays a central role in the regulation of parturition and lactation in the uterus. OXT signaling is mediated by OXT receptor (OXTR), which shows species- and tissue-specific expressions and gene regulation. In the present study, we examined synthesis of OXT and OXTR in human placenta tissue according to gestational age. A total of 48 placentas were divided into early preterm, late preterm, and term groups depending on gestational age, and expression of OXT and OXTR was evaluated...
July 10, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28687839/associations-between-vocal-symptoms-and-genetic-variants-in-the-oxytocin-receptor-and-arginine-vasopressin-1a-receptor-gene
#18
Sofia Holmqvist Jämsen, Ada Johansson, Lars Westberg, Pekka Santtila, Bettina von der Pahlen, Susanna Simberg
Purpose: Oxytocin and arginine vasopressin are associated with different aspects of the stress response. As stress is regarded as a risk factor for vocal symptoms, we wanted to explore the association between the oxytocin receptor gene (OXTR) and arginine vasopressin 1A receptor gene (AVPR1A) single-nucleotide polymorphisms (SNPs) and vocal symptoms. We also wanted to explore whether such effects might be mediated by cortisol because oxytocin and vasopressin are associated with cortisol levels...
July 7, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28652518/the-expression-of-genes-involved-in-myometrial-contractility-changes-during-ex-situ-culture-of-pregnant-human-uterine-smooth-muscle-tissue
#19
Marina Ilicic, Trent Butler, Tamas Zakar, Jonathan W Paul
BACKGROUND: Ex situ analyses of human myometrial tissue has been used to investigate the regulation of uterine quiescence and transition to a contractile phenotype. Following concerns about the validity of cultured primary cells, we examined whether myometrial tissue undergoes culture-induced changes ex situ that may affect the validity of in vitro models. OBJECTIVES: To determine whether human myometrial tissue undergoes culture-induced changes ex situ in Estrogen receptor 1 (ESR1), Prostaglandin-endoperoxide synthase 2 (PTGS2) and Oxytocin receptor (OXTR) expression...
2017: Journal of Smooth Muscle Research, Nihon Heikatsukin Gakkai Kikanshi
https://www.readbyqxmd.com/read/28645747/a-review-of-dna-methylation-in-depression
#20
REVIEW
Dongmei Chen, Lin Meng, Fei Pei, Yang Zheng, Jiyan Leng
As one of the most common psychiatric disorders, depression has been a major public health problem. Growing evidence suggests that epigenetic modification is essential in biological processes of depression. Recently, DNA methylation has been regarded as a potential link between environment and depression. In this review, we reviewed current studies of the association between DNA methylation and depression. The association between DNA methylation of seven genes, including BDNF, SLC6A4, NR3C1, 5-HTR (1A, 2A, and 3A), FKBP5, MAO-A and OXTR, and depression were reviewed in this study...
June 20, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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