keyword
MENU ▼
Read by QxMD icon Read
search

OXTR

keyword
https://www.readbyqxmd.com/read/29306689/genetic-variants-in-oxytocin-receptor-gene-oxtr-and-childhood-physical-abuse-collaborate-to-modify-the-risk-of-aggression-in-chinese-adolescents
#1
Yanmei Zhang, Chunxia Wu, Hongjuan Chang, Qiuge Yan, Linguo Wu, Shanshan Yuan, Jingjing Xiang, Wen Hao, Yizhen Yu
BACKGROUND: Accumulating evidence suggests that genetic and environmental factors may influence aggression susceptibility. However, the etiology of aggressive behavior remains unknown. Compared to some extensively studied candidate genes of aggression, very little is known about the OXTR gene. The objective of this study was to determine whether OXTR genetic variants were associated with aggression risk and whether these polymorphisms showed interactive effects with childhood maltreatment on aggression in Chinese adolescents...
December 21, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29279308/conditional-deletion-of-hippocampal-ca2-ca3a-oxytocin-receptors-impairs-the-persistence-of-long-term-social-recognition-memory-in-mice
#2
Yu-Ting Lin, Tsan-Yu Hsieh, Tsung-Chih Tsai, Chien-Chung Chen, Chiung-Chun Huang, Kuei-Sen Hsu
Oxytocin (OXT) receptors (OXTRs) are prominently expressed in hippocampal CA2 and CA3 pyramidal neurons, but little is known about its physiological function. As the functional necessity of hippocampal CA2 for social memory processing, we tested whether CA2 OXTRs may contribute to long-term social recognition memory (SRM) formation. Here, we found that conditional deletion of Oxtr from forebrain (Oxtr-/-) or CA2/CA3a-restricted excitatory neurons in adult male mice impaired the persistence of long-term SRM but had no effect on sociability and preference for social novelty...
December 26, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29237850/stabilizing-selection-on-microsatellite-allele-length-at-arginine-vasopressin-1a-receptor-and-oxytocin-receptor-loci
#3
Phillip C Watts, Eva R Kallio, Esa Koskela, Eija Lonn, Tapio Mappes, Mikael Mokkonen
The loci arginine vasopressin receptor 1a (avpr1a) and oxytocin receptor (oxtr) have evolutionarily conserved roles in vertebrate social and sexual behaviour. Allelic variation at a microsatellite locus in the 5' regulatory region of these genes is associated with fitness in the bank vole Myodes glareolus Given the low frequency of long and short alleles at these microsatellite loci in wild bank voles, we used breeding trials to determine whether selection acts against long and short alleles. Female bank voles with intermediate length avpr1a alleles had the highest probability of breeding, while male voles whose avpr1a alleles were very different in length had reduced probability of breeding...
December 20, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29237550/the-effects-of-dna-methylation-on-human-psychology
#4
REVIEW
Farzeen Kader, Meenu Ghai, Leah Maharaj
DNA methylation is a fundamental epigenetic modification in the human genome; pivotal in development, genomic imprinting, X inactivation, chromosome stability, gene expression and methylation aberrations are involved in an array of human diseases. Methylation at promoters is associated with transcriptional repression, whereas gene body methylation is generally associated with gene expression. Extrinsic factors such as age, diets and lifestyle affect DNA methylation which consequently alters gene expression...
December 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29235904/molecular-modeling-and-docking-studies-of-the-oxytocin-receptor
#5
Gloria Antobreh, Istvan Enyedy, Aina Westrheim Ravna
AIM: Low oxytocin (OT) level is involved in a number of psychiatric diseases, indicating that OT could be used to aid treating these disorders. OT itself is unable to cross the blood-brain barrier, and development of new small nonpeptide drugs targeting the OT receptor (OXTR) may be beneficial for treating mental disorders. Results & methodology: Three OXTR models were constructed based on crystallized homologous proteins (Protein Data Bank [PDB]: 2Y00, PDB: 4BVN and PDB: 4LDE). The abilities of the models to discriminate between true binders and decoys were analyzed using receiver operating characteristics curves, and the 4LDE-based model gave the best result...
December 13, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29222469/hippocampal-oxytocin-receptors-are-necessary-for-discrimination-of-social-stimuli
#6
Tara Raam, Kathleen M McAvoy, Antoine Besnard, Alexa Veenema, Amar Sahay
Oxytocin receptor (Oxtr) signaling in neural circuits mediating discrimination of social stimuli and affiliation or avoidance behavior is thought to guide social recognition. Remarkably, the physiological functions of Oxtrs in the hippocampus are not known. Here we demonstrate using genetic and pharmacological approaches that Oxtrs in the anterior dentate gyrus (aDG) and anterior CA2/CA3 (aCA2/CA3) of mice are necessary for discrimination of social, but not non-social, stimuli. Further, Oxtrs in aCA2/CA3 neurons recruit a population-based coding mechanism to mediate social stimuli discrimination...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29190530/rare-missense-coding-variants-in-oxytocin-receptor-oxtr-in-schizophrenia-cases-are-associated-with-early-trauma-exposure-cognition-and-emotional-processing
#7
Andre B Veras, Mara Getz, Robert C Froemke, Antonio Egidio Nardi, Gilberto Sousa Alves, Julie Walsh-Messinger, Moses V Chao, Thorsten M Kranz, Dolores Malaspina
BACKGROUND: Oxytocin is a peptide hormone that influences the integration of social cognition with behavior and affect regulation. Oxytocin also prominently directs the transition of neuronal GABA neurotransmission from excitatory to inhibitory after birth. The oxytocin receptor (OXTR) is linked to schizophrenia, a heterogeneous syndrome. Relationships of OXTR polymorphisms with specific clinical features could aid in evaluating any role of oxytocin in the pathogenesis of schizophrenia...
February 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29162179/variation-in-dna-methylation-of-the-oxytocin-receptor-gene-predicts-children-s-resilience-to-prenatal-stress
#8
Izabela Milaniak, Charlotte A M Cecil, Edward D Barker, Caroline L Relton, Tom R Gaunt, Wendy McArdle, Sara R Jaffee
Emerging research in epigenetics has shown that there is variability in how environmental exposures "get under the skin" through mechanisms like DNA methylation to influence gene expression that may lead to differential adaptations to stress. This is the first study to examine prospectively the relationship between DNA methylation at birth and resilience to prenatal environmental stressors in several domains (conduct, hyperactivity, emotional problems, and global symptomatology) in middle childhood. We focused on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously associated with impairments in social-cognitive processes that may underlie a wide range of childhood psychopathology...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29162165/epigenetic-correlates-of-neonatal-contact-in-humans
#9
Sarah R Moore, Lisa M McEwen, Jill Quirt, Alex Morin, Sarah M Mah, Ronald G Barr, W Thomas Boyce, Michael S Kobor
Animal models of early postnatal mother-infant interactions have highlighted the importance of tactile contact for biobehavioral outcomes via the modification of DNA methylation (DNAm). The role of normative variation in contact in early human development has yet to be explored. In an effort to translate the animal work on tactile contact to humans, we applied a naturalistic daily diary strategy to assess the link between maternal contact with infants and epigenetic signatures in children 4-5 years later, with respect to multiple levels of child-level factors, including genetic variation and infant distress...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29125397/oxytocin-receptor-genotype-and-low-economic-privilege-reverses-ventral-striatum-social-anxiety-association
#10
Marlen Z Gonzalez, Meghan H Puglia, James P Morris, Jessica J Connelly
Oxytocin receptor gene (OXTR) polymorphisms, lower ventral striatum (VS) response to social stimuli, and lower economic privilege have been independently associated with depression and anxiety. However, the interactions between these risk factors are unknown. One hundred and fifty-seven healthy adult participants genotyped for OXTR rs237915 completed a common emotion-matching task during functional magnetic resonance imaging. Past economic privilege and depression and anxiety symptoms were concurrently assessed through validated self-report measures...
November 10, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/29123196/identification-of-selection-signals-by-large-scale-whole-genome-resequencing-of-cashmere-goats
#11
Xiaokai Li, Rui Su, Wenting Wan, Wenguang Zhang, Huaizhi Jiang, Xian Qiao, Yixing Fan, Yanjun Zhang, Ruijun Wang, Zhihong Liu, Zhiying Wang, Bin Liu, Yuehui Ma, Hongping Zhang, Qianjun Zhao, Tao Zhong, Ran Di, Yu Jiang, Wei Chen, Wen Wang, Yang Dong, Jinquan Li
Inner Mongolia and Liaoning cashmere goats are two outstanding Chinese multipurpose breeds that adapt well to the semi-arid temperate grassland. These two breeds are characterized by their soft cashmere fibers, thus making them great models to identify genomic regions that are associated with cashmere fiber traits. Whole-genome sequencing of 70 cashmere goats produced more than 5.52 million single-nucleotide polymorphisms and 710,600 short insertions and deletions. Further analysis of these genetic variants showed some population-specific molecular markers for the two cashmere goat breeds that are otherwise phenotypically similar...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29108778/the-timing-and-duration-of-estradiol-treatment-in-a-rat-model-of-the-perimenopause-influences-on-social-behavior-and-the-neuromolecular-phenotype
#12
Alexandra N Garcia, Christina Depena, Kelsey Bezner, Weiling Yin, Andrea C Gore
This study tested the effects of timing and duration of estradiol (E2) treatment, factors that are clinically relevant to hormone replacement in perimenopausal women, on social behavior and expression of genes in brain regions that regulate these behaviors. Female rats were ovariectomized (OVX) at 1year of age, roughly equivalent to middle-age in women, and given E2 or vehicle for different durations (3 or 6months) and timing (immediately or after a 3-month delay) relative to OVX. Social and ultrasonic vocalization (USV) behaviors were assessed at the 3 and 6month timepoints, and the rats' brains were then used for gene expression profiling in hypothalamus (supraoptic nucleus, paraventricular nucleus), bed nucleus of the stria terminalis, medial amygdala, and prefrontal cortex using a 48-gene qPCR platform...
November 8, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29108272/up-regulated-expression-of-oxytocin-mrna-in-peripheral-blood-lymphocytes-from-first-episode-schizophrenia-patients
#13
Xiudeng Yang, Yamei Tang, Qinling Wei, Bing Lang, Huai Tao, Xianghui Zhang, Yong Liu, Aiguo Tang
Schizophrenia (SZ) is a severe neuropsychiatric disorder with significant social cognition impairment. Increasing evidence has suggested that neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) are important mediators of complex social cognition and behavior associates with SZ. In the present study, forty-three first-episode schizophrenia (FES) patients and forty-seven healthy controls (HC) were included. The peripheral mRNA expression of OXT, OXT receptor (OXTR), AVP, AVP 1a receptor (AVPR1a) and CD38 was determined by real-time quantitative polymerase chain reaction (RT-qPCR)...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29102591/hippocampal-gene-expression-patterns-in-oxytocin-male-knockout-mice-are-related-to-impaired-social-interaction
#14
Virginia Meneghini Lazzari, Josi Maria Zimmermann-Peruzatto, Grasiela Agnes, Roberta Oriques Becker, Ana Carolina de Moura, Silvana Almeida, Renata Padilha Guedes, Marcia Giovenardi
Social interaction between animals is crucial for the survival and life in groups. It is well demonstrated that oxytocin (OT) and vasopressin (AVP) play critical roles in the regulation of social behaviors in mammals, however, other neurotransmitters and hormones are involved in the brain circuitry related to these behaviors. The present study aimed to investigate the gene expression of neurotransmitter receptors in the brain of OT knockout (OTKO) male mice. In this study, we evaluated the expression levels of the OT receptor (Oxtr), AVP receptors 1a and 1b (Avpr1a; Avpr1b), dopamine receptor 2 (Drd2), and the estrogen receptors alpha and beta (Esr1; Esr2) genes in the hippocampus (HPC), olfactory bulb (OB), hypothalamus (HPT) and prefrontal cortex (PFC)...
November 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29078292/early-rearing-history-influences-oxytocin-receptor-epigenetic-regulation-in-rhesus-macaques
#15
Maggie Baker, Stephen G Lindell, Carlos A Driscoll, Zhifeng Zhou, Qiaoping Yuan, Melanie L Schwandt, Isaac Miller-Crews, Elizabeth A Simpson, Annika Paukner, Pier Francesco Ferrari, Ravi Kumar Sindhu, Muslima Razaqyar, Wolfgang H Sommer, Juan F Lopez, Robert C Thompson, David Goldman, Markus Heilig, J Dee Higley, Stephen J Suomi, Christina S Barr
Adaptations to stress can occur through epigenetic processes and may be a conduit for informing offspring of environmental challenge. We employed ChIP-sequencing for H3K4me3 to examine effects of early maternal deprivation (peer-rearing, PR) in archived rhesus macaque hippocampal samples (male, n = 13). Focusing on genes with roles in stress response and behavior, we assessed the effects of rearing on H3K4me3 binding by ANOVA. We found decreased H3K4me3 binding at genes critical to behavioral stress response, the most robust being the oxytocin receptor gene OXTR, for which we observed a corresponding decrease in RNA expression...
October 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29057276/genetic-correlates-of-spirituality-religion-and-depression-a-study-in-offspring-and-grandchildren-at-high-and-low-familial-risk-for-depression
#16
Micheline R Anderson, Lisa Miller, Priya Wickramaratne, Connie Svob, Zagaa Odgerel, Ruixin Zhao, Myrna M Weissman
RATIONALE: Possible genetic correlates of spirituality and depression have been identified in community samples. We investigate some of the previously identified candidates in a sample of families at both high and low-risk for depression. METHOD: Offspring and grandchildren of individuals at high and low-risk for depression, participating in a multi-wave thirty-year longitudinal study, were assessed for seven SNPS drawn from four single gene candidates associated with systems implicated in both depression and spirituality: Serotonin (5-HT1B and 5-HT2A), Dopamine (DRD2), Oxytocin (OT) and Monoamine Vesicular Transporter (VMAT1)...
March 2017: Spirituality in Clinical Practice
https://www.readbyqxmd.com/read/29056292/epigenetics-and-gene-expression-profile-in-first-episode-psychosis-the-role-of-childhood-trauma
#17
REVIEW
Simona Tomassi, Sarah Tosato
Childhood Trauma (CT) mediation of the epigenome and its impact on gene expression profile could provide a mechanism for the gene-environment interaction underling psychosis. We reviewed the evidence concerning epigenetic and gene expression modifications associated with CT in both First-Episode Psychosis (FEP) and healthy subjects. In order to explore the relative role of psychosis itself in determining these modifications, evidence about FEP and epigenetics/gene expression was also summarized. We performed a systematic search on PubMed, last updated in December 2016...
October 19, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29033100/oxytocin-receptors-oxtr-and-early-parental-care-an-interaction-that-modulates-psychiatric-disorders
#18
REVIEW
Ilaria Cataldo, Atiqah Azhari, Bruno Lepri, Gianluca Esposito
Oxytocin plays an important role in the modulation of social behavior in both typical and atypical contexts. Also, the quality of early parental care sets the foundation for long-term psychosocial development. Here, we review studies that investigated how oxytocin receptor (OXTR) interacts with early parental care experiences to influence the development of psychiatric disorders. Using Pubmed, Scopus and PsycInfo databases, we utilized the keyword "OXTR" before subsequently searching for specific OXTR single nucleotide polymorphisms (SNPs), generating a list of 598 studies in total...
October 12, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29027364/a-functional-polymorphism-of-the-oxtr-gene-is-associated-with-autistic-traits-in-caucasian-and-asian-populations
#19
Christian Montag, Cornelia Sindermann, Martin Melchers, Sonja Jung, Ruixue Luo, Benjamin Becker, Jiang Xie, Wenming Xu, Adam J Guastella, Keith M Kendrick
There is increasing evidence for associations between polymorphisms of the oxytocin receptor (OXTR) gene and autism spectrum disorder, but to date no study has established links with autistic traits in healthy subjects and potential cultural differences. The present research firstly investigated associations between three widely studied OXTR SNPs and autistic and empathic traits (rs53576 (G/A); rs2254298 (G/A); rs2268498 (T/C)) in two independent studies on male and female Caucasian (n = 537) and Chinese students (n = 280)...
December 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29019100/oxytocin-and-social-cognition
#20
Andreas Ebert, Martin Brüne
Oxytocin has been linked to many domains within the realm of "social cognition." For example, research has shown that oxytocin affects trusting behavior, cooperation, as well as the perception and processing of facial expressions. Furthermore, oxytocin increases empathy and seems to exert differential effects on in-group versus out-group preferences. However, there are some conflicting results that point towards a modulatory effect of oxytocin, depending on a variety of contextual and within-subject factors...
October 11, 2017: Current Topics in Behavioral Neurosciences
keyword
keyword
47179
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"