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Biochemical reference values

Gollapalle Lakshminarayanashastry Viswanatha, Marikunte V Venkataranganna, Nunna Bheema Lingeswara Prasad, Shylaja Hanumanthappa
ETHNOPHARMACOLOGICAL RELEVANCE: Colebrookea oppositifolia Smith is one of the extensively used plants to treat neurological conditions such as epilepsy by the various ethnic communities in sub-Himalayan regions of India such as Bhoxa, Tharu and nomadic Gujjars. AIM OF THE STUDY: This study was conducted to evaluate the cerebroprotective effect of C. oppositifolia methanolic root (MeCO) extract in Wistar rats. MATERIALS AND METHODS: The MeCO was characterized for total phenolic content and later subjected for detailed liquid chromatography-mass spectrometry analysis...
May 16, 2018: Journal of Ethnopharmacology
Po Yen Chen, Po Hui Chiang, Yi Yang Liu, Yao Chi Chuang, Yuan Tso Cheng
OBJECTIVES: To identify predictive factors of biochemical recurrence for patients undergoing high-intensity focused ultrasound treatment for localized prostate cancer. METHODS: We retrospectively identified patients receiving whole-gland prostate ablation with high-intensity focused ultrasound for localized prostate cancer from 2009 to 2015. All the patients received pre-high-intensity focused ultrasound radical transurethral resection of the prostate. We included perioperative parameters as follows: age, preoperative prostate volume, stage of operation, initial prostate-specific antigen, T stage, postoperative prostate-specific antigen nadir, Gleason score, time to prostate-specific antigen nadir and the presence of prostate-specific antigen biochemical recurrence...
May 13, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
Josefina Del Brio, Cristina Mónica Montagna, Betsabé Ailén Lares, María Eugenia Parolo, Andrés Venturino
Chemical and toxicological crude oil analysis was performed on water-accommodated fraction of oil (WAF). This study characterized the chemical composition of WAF and its dissipation over a period of 192 h. Acute (96 h) and chronic (14 d) toxicity of WAF were evaluated on Hyalella curvispina from both reference (Los Barreales lake, LB) and hydrocarbon-contaminated (Durán stream, DS) sites. The total hydrocarbon (TPHs) concentration in WAF was 2.18 mg L-1 . The dissipation rates of hydrocarbons in WAF showed a first-order kinetics, with half-lives ranging between 65 h-200 h...
April 30, 2018: Environmental Toxicology and Pharmacology
Semra Ince, Ozdes Emer, Salih Deveci, Kursat Okuyucu, Engin Alagoz, Huseyin San, Aslı Ayan, Ozgur Karacalioglu, Cem Haymana, Bengul Gunalp, Nuri Arslan
OBJECTIVE: Parathyroid scintigraphy (PS) can be negative or equivocal (N/E) in a considerable number of cases with highly suspicious clinical findings and biochemical results for parathyroid adenoma (PA). The aims of this study were to investigate the complementary role of parathormone washout test (PWT) to PS in patients with primary hyperparathyroidism (PHPT) and evaluate histopathologic aspects of PAs in comparison with PS results. MATERIAL AND METHODS: Thirty-eight patients with PHPT referred for PS were included in the study...
May 2, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
J S Osterberg, K M Cammen, T F Schultz, B W Clark, R T Di Giulio
In many human-altered ecosystems, organisms are increasingly faced with more diverse and complex environmental stressors and pollutant mixtures, to which the adaptations necessary to survive exposure are likely to be numerous and varied. Improving our understanding of the molecular mechanisms that underlie complex polygenic adaptations in natural settings requires significant toxicological, biochemical, physiological, and genomic data rarely available for non-model organisms. Here, we build upon two decades of study of adaptation to anthropogenic pollutants in a population of Atlantic killifish (Fundulus heteroclitus) that inhabits the creosote-contaminated Atlantic Wood Industries Superfund (AW) site on the Elizabeth River, Virginia in the United States...
April 25, 2018: Aquatic Toxicology
Shih-Yu Chen, Yi-Lun Tsai, Suen-Chuain Lin, Yeong-Huey Wu, Ming-Huei Liao, Ching-Dong Chang, Tsung-Hsien Li, Hsiao-Kuang Ho
Hematology and serum biochemistry reference values are essential for health evaluation and disease diagnosis in penguins. However, there are currently no published physiological values for captive Adélie (Pygoscelis adeliae) and Chinstrap penguins (P. antarcticus), nor for wild or captive Macaroni penguins (Eudyptes chrysolophus). The present study is the first investigation regarding hematology and serum biochemistry reference values for captive Adélie, Gentoo (P. papua), Chinstrap, and Macaroni penguins in Asia...
May 3, 2018: Zoo Biology
Ruth Birk, Eliyahu M Heifetz
BACKGROUND: Biochemical laboratory values are an essential tool in medical diagnosis, treatment, and follow-up; however, they are known to vary between populations. Establishment of ethnicity-adjusted reference values is recommended by health organizations. AIM: To investigate the ethnicity element in biochemical lab values studying women of different ethnic groups. METHODS: Biochemical lab values (n = 27) of 503 adult Israeli women of three ethnicities (Jewish Ashkenazi, Jewish Sephardic, and Bedouin Arab) attending a single medical center were analyzed...
April 28, 2018: Irish Journal of Medical Science
Jonah Popp, John A Nyman, Xianghua Luo, Jill Bengtson, Katherine Lust, Lawrence An, Jasjit S Ahluwalia, Janet L Thomas
OBJECTIVES: We conducted a cost-effectiveness analysis and model-based cost-utility and cost-benefit analysis of increased dosage (3 vs. 1 consecutive contests) and enhanced content (supplemental smoking-cessation counseling) of the Quit-and-Win contest using data from a randomized control trial enrolling college students in the US. METHODS: For the cost-utility and cost-benefit analyses, we used a microsimulation model of the life course of current and former smokers to translate the distribution of the duration of continuous abstinence among each treatment arm's participants observed at the end of the trial (N = 1217) into expected quality-adjusted life-years (QALYs) and costs and an incremental net monetary benefit (INMB)...
April 23, 2018: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
Oladunni Akin-Akintayo, Funmilayo Tade, Pardeep Mittal, Courtney Moreno, Peter T Nieh, Peter Rossi, Dattatraya Patil, Raghuveer Halkar, Baowei Fei, Viraj Master, Ashesh B Jani, Hiroumi Kitajima, Adeboye O Osunkoya, Claudia Ormenisan-Gherasim, Mark M Goodman, David M Schuster
PURPOSE: To investigate the disease detection rate, diagnostic performance and interobserver agreement of fluciclovine (18 F) PET-CT and multiparametric magnetic resonance imaging (mpMR) in recurrent prostate cancer. METHODS: Twenty-four patients with biochemical failure after non-prostatectomy definitive therapy, 16/24 of whom had undergone brachytherapy, underwent fluciclovine PET-CT and mpMR with interpretation by expert readers blinded to patient history, PSA and other imaging results...
May 2018: European Journal of Radiology
Leah K Bartel, Daniel A Hunter, Kayla B Anderson, W Yau, Ji Wu, Worlanyo E Gato
Various in vitro and in vivo studies have shown titanium dioxide nanoparticles (TDNPs) increase the production of reactive oxygen species and change the expression of genes and proteins involved in the inflammatory response and cell division. Although, the cytotoxicity of TDNPs has been shown to be largely dependent on the characteristics of the particles including shape and surface area. This present study investigates the effects of titanium dioxide nanofibers (TDNFs) with a diameter of 300-800 nm, on the histopathology of liver tissue, changes in feed efficiency and liver weights, changes in hepatic gene expression, and serum biochemical parameters in male Sprague-Dawley rats...
April 23, 2018: Drug and Chemical Toxicology
Andrew Barrick, Jean-Marie Marion, Hanane Perrein-Ettajani, Amelie Châtel, Catherine Mouneyrac
Identification of contamination in estuarine ecosystems that are impacted by anthropogenic pressures, such as the Seine estuary, is difficult to determine without considering the role environmental variation plays on the end points selected. Currently, there is interest in identifying methods in which the influence of confounding factors can be described and accounted for. In this context, the aim of this study was to define a baseline assessment criteria (BAC) for enzymatic biomarkers in ragworms (Hediste diversicolor) collected in a reference site (Authie)...
April 2018: Marine Pollution Bulletin
Chun-Gon Kim, Jong-Pyo Kang, Yue Huo, Mohan Chokkalingam, Yeon-Ju Kim, Dong-Hyun Kim, Deok-Chun Yang
A novel bacterium, designated DCY114T , was isolated from ginseng-cultivated soil in Gochang-gun, Republic of Korea. This isolate was assigned to the genus Paenibacillus and is closely related to Paenibacillus amylolyticus NRRL NRS-290T (98.3%), P. dongdonensis KUDC0114T (98.0%), P. tylopili MK2T (97.9%), P. tundrae A10bT (97.8%), and P. xylanexedens B22aT (97.5%) based on 16S rRNA gene sequence analysis. Strain DCY114T is a Gram-reaction positive, catalase and oxidase positive, facultatively aerobic rod that is motile by peritrichous flagella...
April 20, 2018: Archives of Microbiology
Masoud Neghab, Hamed Jalilian, Shekoufeh Taheri, Mohsen Tatar, Zeynab Haji Zadeh
AIMS: Recently concern has been raised regarding possible health effects of exposure of pesticide retailers to chemicals they handle. Additionally, it is not known whether exposure to these compounds by retailers may be associated with any liver and kidney dysfunction or hematological abnormalities. This study was undertaken to address these issue. MAIN METHODS: In this cross-sectional study, 70 male pesticide retailers (cases) and 64 male subjects, randomly selected from the constructions workers of city council contractors, as the referent group, were investigated...
April 13, 2018: Life Sciences
Anca Oana Docea, Eliza Gofita, Marina Goumenou, Daniela Calina, Otilia Rogoveanu, Marius Varut, Cristian Olaru, Efthalia Kerasioti, Polyxeni Fountoucidou, Ioannis Taitzoglou, Ovidiu Zlatian, Valerii N Rakitskii, Antonio F Hernandez, Dimitrios Kouretas, Aristidis Tsatsakis
This study assessed the potential adverse health effects of long-term low-dose exposure to chemical mixtures simulating complex real-life human exposures. Four groups of Sprague Dawley rats were administered mixtures containing carbaryl, dimethoate, glyphosate, methomyl, methyl parathion, triadimefon, aspartame, sodium benzoate, calcium disodium ethylene diamine tetra-acetate, ethylparaben, butylparaben, bisphenol A, and acacia gum at doses of 0, 0.25, 1 or 5 times the respective Toxicological Reference Values (TRV): acceptable daily intake (ADI) or tolerable daily intake (TDI) in a 24 weeks toxicity study...
April 2, 2018: Food and Chemical Toxicology
Amelia Geraldine Peregrina-Chávez, María Del Rayo Ramírez-Galindo, Rolando Chávez-Martínez, Cesar Anuar Delahanty-Delgado, Fernando Vazquez-Alaniz
Background: The biological behaviour and clinical significance of mercury toxicity vary according to its chemical structure. Mercury differs in its degree of toxicity and in its effects on the nervous, digestive and immune systems as well as on organs such as the lungs, kidneys, skin, eyes and heart. Human exposure occurs mainly through inhalation of elemental mercury vapours during industrial and artisanal processes such as artisanal and small-scale gold mining. Case presentation: A 52-years-old female, housewife, with a body mass index of 25...
April 2, 2018: International Journal of Environmental Research and Public Health
Nathalie Chérot-Kornobis, Sébastien Hulo, Jonathan Giovannelli, Virginie de Broucker, Régis Matran, Philippe Amouyel, Annie Sobaszek, Luc Dauchet, Jean-Louis Edmé
BACKGROUND: Biomarkers in exhaled breath condensate (EBC) are potentially sensitive indicators of early biochemical changes in airways following exposure to pneumotoxic substances, particularly in susceptible subjects. NOx are the stable end products of the nitrite-nitrate-NO oxidative stress pathway and can be used to monitor airway inflammatory diseases, especially in asthma. Nevertheless, population-based surveys are needed to better interpret EBC NOx levels in clinical studies. The aim of this study was to establish reference values of EBC NOx in a large group of middle-aged, healthy adults of a sample of the general population with particular focus on the smoking status...
April 2018: Respiratory Medicine
Susana Agusti Montolio, Rafaela Cuenca Valera, Santiago Lavín González, Carolyn Cray, Rafael Molina López, Emmanuel Serrano Ferron, Olga Nicolás Francisco, Ignasi Marco Sánchez, Encarna Casas-Díaz
BACKGROUND: Blood biochemistry and hematology are essential in the laboratory diagnosis of disease. In Strigiformes, little information regarding reference values and influence of different preanalytic factors is available, while age is known to have an effect on some biochemistry analytes, especially in early life characterized by a rapid growth rate and increase in body mass. OBJECTIVE: The objective of this study was to determine baseline data for 29 blood biochemistry variables in 5 species of Iberian Strigiformes assigned to different age classes...
March 2018: Veterinary Clinical Pathology
Maria Grazia Chiofalo, Simona Signoriello, Franco Fulciniti, Nicola Avenia, Serenella Ristagno, Celestino Pio Lombardi, Angelo Nicolosi, Maria Rosa Pelizzo, Giuliano Perigli, Andrea Polistena, Vincenzo Panebianco, Rocco Bellantone, Pietro Giorgio Calò, Isabella Merante Boschin, Benedetta Badii, Massimo Di Maio, Ciro Gallo, Francesco Perrone, Luciano Pezzullo
PURPOSE: To assess the role of clinical, biochemical, and morphological parameters, as added to cytology, for improving pre-surgical diagnosis of palpable thyroid nodules. METHODS: Patients with a palpable thyroid nodule were eligible if surgical intervention was indicated after a positive or suspicious for malignancy FNAC (TIR 4-5 according to the 2007 Italian SIAPEC-IAP classification), or two inconclusive FNAC at a ≥3 months interval, or a negative FNAC associated with one or more risk factor...
March 22, 2018: Endocrine
Leigh Anne Harden, Jennifer Fernandez, Joseph R Milanovich, Brock P Struecker, Stephen R Midway
Blood biochemical and hematology analyses are helpful indicators of the physiologic health of animals, particularly when making conservation and management decisions for threatened species. In this study, we 1) established blood biochemical reference intervals for two populations of threatened, free-ranging ornate box turtles ( Terrapene ornata) in northern Illinois during their active season and 2) examined the effects of individual carapace temperature ( Tc ) on blood biochemical variables by using a Bayesian hierarchic framework...
March 21, 2018: Journal of Wildlife Diseases
Shetty Sushruth, Chellappa Vijayakumar, Krishnamachari Srinivasan, Nagarajan Raj Kumar, Gopal Balasubramaniyan, Surendra K Verma, A Ramesh
Background Right iliac fossa (RIF) pain is one of the most common modalities of presentation to surgical emergency. It remains a challenge to the treating clinicians to accurately diagnose or to rule out appendicitis. Objective The aim of the study was to compare the efficacy of clinical impression, biochemical markers, and imaging in the diagnosis of RIF pain with special reference to appendicitis and their implication in reducing the negative appendicectomy rates. Methods All patients presenting to casualty with RIF pain were included in the study...
January 15, 2018: Curēus
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