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https://www.readbyqxmd.com/read/27812403/the-impact-of-il-6-and-il-28b-gene-polymorphisms-on-treatment-outcome-of-chronic-hepatitis-c-infection-among-intravenous-drug-users-in-croatia
#1
Zoran Bogdanović, Ivana Marinović-Terzić, Sendi Kuret, Ana Jerončić, Nikola Bradarić, Gea Forempoher, Ozren Polašek, Šimun Anđelinović, Janoš Terzić
BACKGROUND: Several genes and their single nucleotide polymorphisms (SNPs) are associated with either spontaneous resolution of hepatitis C infection or better treatment-induced viral clearance. We tested a cohort of intravenous drug users (IVDU) diagnosed with chronic hepatitis C virus (HCV) for treatment response and its association with the SNPs in the interleukin-6 (rs1800795-IL6) and the interleukin-28B (rs12979860-IL28B) genes. METHODS: The study included 110 Croatian IVDU positive for anti-HCV antibody...
2016: PeerJ
https://www.readbyqxmd.com/read/27387326/navigating-hiv-prevention-policy-and-islam-in-malaysia-contention-compatibility-or-reconciliation-findings-from-in-depth-interviews-among-key-stakeholders
#2
Sima Barmania, Syed Mohamed Aljunid
BACKGROUND: Malaysia is a multicultural society, predominantly composed of a Muslim majority population, where Islam is influential. Malaysia has a concentrated HIV epidemic amongst high risk groups, such as, Intravenous Drug Users (IVDU), sex workers, transgender women and Men who have sex with Men (MSM). The objective of this study is to understand how Islam shapes HIV prevention strategies in Malaysia by interviewing the three key stakeholder groups identified as being influential, namely the Ministry of Health, Religious leaders and People living with HIV...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27239001/rhizobium-radiobacter-endocarditis-in-an-intravenous-drug-user-clinical-presentation-diagnosis-and-treatment
#3
Bilal A Zahoor
Rhizobium radiobacter, a soil-based organism, is not, usually, pathogenic unless in the immunecompromised. Endocarditis, in the immunocompromised, is a typical presentation generally as a result of catheter-based infections. We describe the presentation of R. radiobacter prosthetic valve endocarditis and the inherent challenges in its presentation and diagnosis. A patient presented with acute limb ischemia secondary to R. radiobacter-mediated endocarditis and subsequent thromboembolization of the distal superior femoral and proximal popliteal arteries in the left lower limb...
August 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27043886/hbsag-and-anti-hcv-screening-in-elderly-hospitalized-patients-of-a-german-tertiary-referral-centre
#4
J Kant, J Kratzsch, M Maier, U G Liebert, T Berg, J Wiegand
BACKGROUND: Elderly patients are under-represented in hepatitis B and C screening approaches, but may be at increased risk for advanced liver disease. We therefore screened a hospitalized elderly population. MATERIALS AND METHODS: 6011 admissions to the department of internal medicine and neurology within one year were screened for HBsAg and anti-HCV (Elecsys(®)-HBsAg and -anti-HCV). Positive anti-HCV results were confirmed with the INNO-LIA™ assay. HCV-RNA was analyzed by real-time PCR in the case of confirmed positive anti-HCV results, HBV-DNA in the confirmed HBsAg positive individuals...
March 2016: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27009250/acute-hepatitis-b-after-the-implementation-of-universal-vaccination-in-italy-results-from-22-years-of-surveillance-1993-2014
#5
Maria Elena Tosti, Valeria Alfonsi, Eleonora Lacorte, Alfonso Mele, Cristina Galli, Alessandro Remo Zanetti, Luisa Romanò
BACKGROUND: Hepatitis B vaccination has proven to be very safe and highly effective. This study assessed the proportion of successfully vaccinated individuals among cases with acute hepatitis B, the proportion of preventable cases if individuals were vaccinated as recommended, and the reasons for failures. METHODS: We analyzed data reported to the Italian Surveillance System for Acute Viral Hepatitis from 1993 to 2014. RESULTS: A total of 362 of 11 311 (3...
June 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/26871824/clinical-features-and-outcomes-of-patients-with-genotype-3-hepatitis-c-virus-infection-in-korea-a-retrospective-observational-study
#6
Ra Ri Cha, Sang Soo Lee, Chang Min Lee, Sung Bok Ji, Hee Cheul Jung, Hyun Chin Cho, Jin Joo Kim, Jae Min Lee, Hong Jun Kim, Chang Yoon Ha, Hyun Jin Kim, Tae-Hyo Kim, Woon Tae Jung, Ok-Jae Lee
Hepatitis C virus (HCV) genotype 3 infection is very rare in high-income Asia Pacific. The aim of our retrospective observational study was to evaluate the incidence, clinical features, and treatment outcomes of patients with a genotype 3 HCV infection in the Gyeongnam Province of Korea. Ninety-eight consecutive patients diagnosed with a genotype 3 HCV infection at Gyeongsang National University Hospital, between January 2005 and December 2014, were enrolled into the study. Relevant characteristics of the study group included: 80...
February 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26798070/hcv-prevalence-in-asian-americans-in-california
#7
Oliver N Lin, Christine Chang, Joyce Lee, Ailinh Do, Marina Martin, Andy Martin, Mindie H Nguyen
The World Health Organization estimates that 170 million persons are infected with HCV worldwide, but only 22 million are from the Americas and Europe, compared to 94 million from Asia. HCV prevalence in the general US population is 1.6 %, but data for Asian Americans are limited. Our goal was to examine HCV prevalence in Asian Americans in a large ethnically diverse patient cohort seeking primary care at a free clinic in Northern California. A total of 1347 consecutive patients were seen from September 2009 to October 2012 and were studied via individual chart review using case report forms...
January 21, 2016: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/26698255/different-impact-of-nnrti-and-pi-including-haart-on-bone-mineral-density-loss-in-hiv-infected-patients
#8
G Madeddu, A Spanu, P Solinas, S Babudieri, G M Calia, C Lovigu, M Mannazzu, S Nuvoli, B Piras, P Bagella, M S Mura, G Madeddu
OBJECTIVE: To evaluate the changes in Bone Mineral Density (BMD) and bone remodelling markers in a group of HIV patients treated with HAART and controlled in a long follow-up and to identify possible risk factors for accelerated bone mass loss. PATIENTS AND METHODS: In a series of 172 HIV patients treated with HAART a total of 67 patients (44 males and 33 females) underwent repeated bone mineral density measurement by DEXA in lumbar spine and in femur; the patients were classified according to T-score WHO criteria...
December 2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26690071/infective-endocarditis-in-patients-with-hepatic-diseases
#9
E Seminari, A De Silvestri, V Ravasio, S Ludovisi, R Utili, N Petrosillo, F Castelli, M Bassetti, F Barbaro, P Grossi, N Barzaghi, M Rizzi, L Minoli
Few data have been published regarding the epidemiology and outcome of infective endocarditis (IE) in patients with chronic hepatic disease (CHD). A retrospective analysis of the Studio Endocarditi Italiano (SEI) database was performed to evaluate the epidemiology and outcome of CHD+ patients compared with CHD- patients. The diagnosis of IE was defined in accordance with the modified Duke criteria. Echocardiography, diagnosis, and treatment procedures were in accordance with current clinical practice. Among the 1722 observed episodes of IE, 300 (17...
February 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/26687478/surgical-and-medical-management-of-isolated-tricuspid-valve-infective-endocarditis-in-intravenous-drug-users
#10
Nabha Shetty, Dave Nagpal, Sharon Koivu, Marko Mrkobrada
BACKGROUND: Tricuspid valve (TV) infective endocarditis (IE) is a known complication of intravenous drug use (IVDU). This study assessed long-term outcomes of surgically and medically treated cases of TV IE. METHODS: This was a retrospective cohort study of all cases of native TV IE treated in London, Ontario between 2008 and 2011. Outcomes for medically and surgically managed cases were assessed at two years. Outcomes related to the timing of surgery were also assessed...
February 2016: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/26455253/optimising-the-use-of-transoesophageal-echocardiography-in-diagnosing-suspected-infective-endocarditis
#11
COMPARATIVE STUDY
Monica I Rap, Abraham Chacko
OBJECTIVES: We evaluated the clinical indication and incremental diagnostic yield gained by transoesophageal echocardiography (TOE) performed after transthoracic echocardiography (TTE) in patients with suspected infective endocarditis (IE). METHODS AND RESULTS: We retrospectively analysed 60 pairs of TOE and TTE exams for suspected IE, performed between July 2011 and July 2013 in our district general hospital. The TOE results were classified as 'positive' or'negative' based on the Duke criteria, while TTEs were classified as 'no vegetation', 'vegetation', 'suspected vegetation' and 'cannot exclude vegetation' according to the final reports...
August 2015: Acta Cardiologica
https://www.readbyqxmd.com/read/26434076/rapidly-progressive-seeding-of-a-community-acquired-pathogen-in-an-immune-competent-host-end-organ-damage-from-head-to-bone
#12
Daisy Torres-Miranda, Farah Al-Saffar, Saif Ibrahim, Stephanie Font-Diaz
This report describes a 64-years-old male patient that presented to our hospital with a chief complaint of acute worsening of his usual chronic lower back pain, progressive weakness in lower extremities and subjective fevers at home. Spine CT failed to demonstrate any infectious foci but showed partially visualized lung cavitary lesion and renal pole abnormalities. Blood cultures grew methicillin-sensitive Staphylococcus Aureus (MSSA). Transthoracic echocardiogram (TTE) showed no signs of infective endocarditis (IE)...
April 2015: Boletín de la Asociación Médica de Puerto Rico
https://www.readbyqxmd.com/read/26372394/ifnl4-rs368234815-polymorphism-is-associated-with-innate-resistance-to-hiv-1-infection
#13
Luis M Real, Rocío Herrero, Antonio Rivero-Juárez, Ángela Camacho, Juan Macías, Sandra Vic, Vincent Soriano, Sergio Viedma, Josep M Guardiola, Joan Fibla, Antonio Rivero, Juan A Pineda, Antonio Caruz
The interferon (IFN)L4 polymorphism rs368234815 is associated with hepatitis C virus (HCV) spontaneous clearance and response to IFN-based treatments. The role of this polymorphism in HIV-1 infection is controversial. We investigated whether genetic variation at IFNL4 is associated to HIV-1 acquisition. The HCV protective allele TT was associated with decreased likelihood of HIV-1 infection in male intravenous drug users [odds ratio (OR): 0.3; P = 0.006], and this association was not modified by the genotype of CCR5...
September 10, 2015: AIDS
https://www.readbyqxmd.com/read/26345172/dermatopathologic-manifestations-of-intravenous-drug-use
#14
Julie Y Tse, Morayo Adisa, Lynne J Goldberg, Rosalynn M Nazarian
BACKGROUND: The rate of intravenous drug use (IVDU) has been increasing nationally; however, cutaneous manifestations of IVDU have infrequently been investigated. We report a series of the clinicopathological correlation of IVDU in the skin. METHODS: A search of surgical pathology files between the years 2000 and 2014 was performed for cutaneous specimens from patients with a reported history of IVDU for which the histopathological findings could not be attributed to another etiology...
November 2015: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/26344539/managing-leg-ulceration-in-intravenous-drug-users
#15
Jemell Geraghty
Chronic venous leg ulceration is a long-term condition commonly associated with lower-limb injecting and chronic venous hypertension caused by collapsed veins, incompetent valves, deep vein thrombosis and reflux. It is not usually a medical emergency, but intravenous (IV) drug users with leg ulcers can attend emergency departments (EDs) with a different primary complaint such as pain or because they cannot access local primary care or voluntary services. Leg ulceration might then be identified during history taking, so it is important that ED nurses know how to assess and manage these wounds...
September 2015: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/26325070/genotype-distribution-and-molecular-epidemiology-of-hepatitis-c-virus-in-hubei-central-china
#16
Jing Peng, Yanjun Lu, Weiyong Liu, Yaowu Zhu, Xiaoling Yan, Jingxin Xu, Xiong Wang, Yue Wang, Wei Liu, Ziyong Sun
BACKGROUND: Little is known about the molecular epidemiology of hepatitis C virus (HCV) infection in Central China. METHODOLOGY/PRINCIPAL FINDINGS: A total of 570 patients from Hubei Province in central China were enrolled. These patients were tested positive for HCV antibody prior to blood transfusion. Among them, 177 were characterized by partial NS5B and/or Core-E1 sequences and classified into five subtypes: 1b, 83.0% (147/177); 2a, 13.0% (23/177); 3b, 2.3% (4/177); 6a, 1...
2015: PloS One
https://www.readbyqxmd.com/read/26305822/ultra-deep-sequencing-provides-insights-into-the-virology-of-hepatitis-c-super-infections-in-a-case-of-three-sequential-infections-with-different-genotypes
#17
REVIEW
Emily Chung, R Bridget Ferns, Miao He, Roberto Rigatti, Paul Grant, Adele McCormick, Sanjay Bhagani, Daniel Peter Webster, Eleni Nastouli, Laura Jane Waters
The current epidemic of Hepatitis C infection in HIV-positive men who have sex with men is associated with increasing use of recreational drugs. Multiple HCV infections have been reported in haemophiliacs and intravenous drug users. Using ultra-deep sequencing analysis, we present the case of an HIV-positive MSM with evidence of three sequential HCV infections, each occurring during the acute phase of the preceding infection, following risk exposures. We observed rapid replacement of the original strain by the incoming genotype at subsequent time points...
September 2015: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/26302493/a-population-structured-hiv-epidemic-in-israel-roles-of-risk-and-ethnicity
#18
Zehava Grossman, Boaz Avidor, Zohar Mor, Michal Chowers, Itzchak Levy, Eduardo Shahar, Klaris Riesenberg, Zev Sthoeger, Shlomo Maayan, Wei Shao, Margalit Lorber, Karen Olstein-Pops, Daniel Elbirt, Hila Elinav, Ilan Asher, Diana Averbuch, Valery Istomin, Bat Sheva Gottesman, Eynat Kedem, Shirley Girshengorn, Zipi Kra-Oz, Yonat Shemer Avni, Sara Radian Sade, Dan Turner, Frank Maldarelli
BACKGROUND: HIV in Israel started with a subtype-B epidemic among men who have sex with men, followed in the 1980s and 1990s by introductions of subtype C from Ethiopia (predominantly acquired by heterosexual transmission) and subtype A from the former Soviet Union (FSU, most often acquired by intravenous drug use). The epidemic matured over the last 15 years without additional large influx of exogenous infections. Between 2005 and 2013 the number of infected men who have sex with men (MSM) increased 2...
2015: PloS One
https://www.readbyqxmd.com/read/26286450/personality-disorders-do-not-affect-treatment-outcomes-for-chronic-hcv-infection-in-spanish-prisoners-the-perseo-study
#19
MULTICENTER STUDY
Andrés Marco, José J Antón, Joan Trujols, Pablo Saíz de la Hoya, José de Juan, Inmaculada Faraco, Joan A Caylà
BACKGROUND: The link between infection with hepatitis C virus (HCV) and personality disorders (PD) has not been investigated in detail. The aim of this study was to compare the effectiveness of HCV treatment in prisoners with and without PD. METHODS: We performed a prospective multicentre study in inmates from 25 Spanish prisons who had been treated with pegylated interferon alfa-2a plus ribavirin in 2011. PD diagnosis was based on the Personality Diagnostic Questionnaire-4+...
August 19, 2015: BMC Infectious Diseases
https://www.readbyqxmd.com/read/26285016/a-survey-of-increased-infectious-risk-donor-utilization-in-canadian-transplant-programs
#20
Deepali Kumar, Atul Humar, S Joseph Kim, Bryce Kiberd
BACKGROUND: Donors at increased risk of transmitting viral infections are a potential source of transplantable organs. Studies demonstrate that organs from increased risk donors (IRDs) are associated with excellent outcomes. However, considerable variation in practice likely exists. METHODS: We performed a cross-country survey of Canadian Organ Transplant centers to determine organ utilization practices from IRDs. RESULTS: Of 40 surveys sent to transplant programs across Canada, 24 (60%) were returned...
February 2016: Transplantation
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