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https://www.readbyqxmd.com/read/29660384/development-of-a-recombinant-%C3%AF-b-protein-based-dot-elisa-for-the-diagnosis-of-avian-reovirus-arv
#1
Saurabh Majumdar, Tapan K S Chauhan, K Dhama, Purushottam P Goswami, A K Tiwari, B P Mishra, Deepak Kumar
No abstract text is available yet for this article.
April 13, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29660214/precore-g1896a-mutation-is-associated-with-reduced-rates-of-hbsag-seroclearance-in-treated-hiv-hepatitis-b-virus-co-infected-patients-from-western-africa
#2
Anders Boyd, Raoul Moh, Sarah Maylin, Mariama Abdou Chekaraou, Nadia Mahjoub, Delphine Gabillard, Xavier Anglaret, Serge Paul Eholié, Constance Delaugerre, Christine Danel, Fabien Zoulim, Karine Lacombe
The nucleotide substitution G1896A on the precore (pc) region has been implicated in virological and serological responses during treatment in hepatitis B virus (HBV)-infected patients. Whether this mutation affects the therapeutic course of HIV-HBV co-infected patients, especially from Western Africa, is unknown. In this prospective cohort study, 86 antiretroviral (ARV)-naïve HIV-HBV co-infected patients from Côte d'Ivoire, initiating ARV-treatment containing lamivudine (n=53) or tenofovir (n=33), had available baseline pc sequences...
April 16, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29658813/kinematic-upper-extremity-performance-in-people-with-near-or-fully-recovered-sensorimotor-function-after-stroke
#3
Gyrd Thrane, Katharina S Sunnerhagen, Hanna C Persson, Arve Opheim, Margit Alt Murphy
BACKGROUND: Clinical scales for upper extremity motor function may not capture improvement among higher functioning people with stroke. OBJECTIVE: To describe upper extremity kinematics in people with stroke who score within the upper 10% of the Fugl-Meyer Assessment (FMA-UE) and explore the ceiling effects of the FMA-UE. DESIGN: A cross-sectional study design was used. PARTICIPANTS: People with stroke were included from the Stroke Arm Longitudinal Study at University of Gothenburg together with 30 healthy controls...
April 16, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29650710/plasma-concentrations-and-dietary-intakes-of-choline-and-betaine-in-association-with-atrial-fibrillation-risk-results-from-3-prospective-cohorts-with-different-health-profiles
#4
Hui Zuo, Gard F T Svingen, Grethe S Tell, Per M Ueland, Stein E Vollset, Eva R Pedersen, Arve Ulvik, Klaus Meyer, Jan E Nordrehaug, Dennis W T Nilsen, Kaare H Bønaa, Ottar Nygård
BACKGROUND: Although choline metabolism has been associated with atherosclerotic heart disease, less research attention has been paid to the associations of choline and its oxidative metabolite betaine with cardiac arrhythmias. METHODS AND RESULTS: We evaluated associations of plasma concentrations and dietary intakes of choline and betaine with long-term atrial fibrillation (AF) risk in a community-based cohort, HUSK ([the Hordaland Health Study] n=6949), and validated the findings in 2 patient cohorts: the Western Norway Coronary Angiography Cohort (n=4164) and the NORVIT (Norwegian B-Vitamin) Trial (n=3733)...
April 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29649980/patterns-of-caesarean-section-in-hiv-infected-and-non-infected-women-in-malawi-is-caesarean-section-used-for-pmtct
#5
Lyson Tenthani, Joep J van Oosterhout, Andreas D Haas, Malango Msukwa, Nozgechi Phiri, Frank Chimbwandira, Kali Tal, Karoline Aebi-Popp, Janne Estill, Olivia Keiser
BACKGROUND: Caesarean section (CS) is not recommended for PMTCT in Malawi HIV Guidelines, contrary to most high-income countries where CS is indicated if viral suppression is sub-optimal pre-delivery. We describe patterns of CS in HIV-infected and uninfected women in Malawi and explored if insight into the use of Elective CS (ECS) for PMTCT could be obtained. METHODS: We used routinely collected data from individual medical records from 17 large health facilities in the central and southern regions of Malawi, from January 2010 to December 2013...
April 12, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29649076/pharmacokinetics-of-tenofovir-alafenamide-when-co-administered-with-other-hiv-antiretrovirals
#6
Rebecca Begley, Moupali Das, Lijie Zhong, John Ling, Brian P Kearney, Joseph M Custodio
BACKGROUND: Tenofovir alafenamide (TAF), a prodrug of the nucleotide analogue tenofovir (TFV), is an antiretroviral (ARV) agent approved either as a complete regimen (elvitegravir/cobicistat/emtricitabine (F)/tenofovir alafenamide (TAF), rilpivirine/F/TAF, bictegravir/F/TAF), or for use with other ARVs (F/TAF), for treatment of HIV. TAF is a substrate of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) transporters. Disposition of TAF may be altered by co-medications that can inhibit or induce P-gp or BCRP transporters...
April 10, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29623779/long-term-use-of-darunavir-ritonavir-containing-regimens-in-daily-practice-in-belgium-retrospective-observational-cohort-data-of-1701-hiv-patients
#7
Stéphane De Wit, Eric Florence, Linos Vandekerckhove, Bernard Vandercam, Jean-Christophe Goffard, Eric Van Wijngaerden, Michel Moutschen, Remy Demeester, Pushpike Thilakarathne, Hilde Piryns
Background Once daily (QD) ritonavir or cobicistat-boosted darunavir (DRV/b), in combination with other antiretrovirals (ARVs), is recommended as a first-line option for human immunodeficiency virus-infected patients in European and USA guidelines. The objective of this study was to analyse the outcomes of DRV/r QD-based antiretroviral therapy (ART) regimens in real-life settings. Methods This is an observational, non-interventional, non-comparative, retrospective, multicentre cohort study. Data were collected from the databases of eight Belgian AIDS Reference Centres...
April 6, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29620934/factors-associated-with-lower-respiratory-tract-infections-in-hiv-exposed-uninfected-infants
#8
Adriana Weinberg, Marisa Mussi-Pinhata, Qilu Yu, Rachel A Cohen, Volia C Almeida, Fabiana R Amaral, Laura Freimanis, D Robert Harris, Christiana Smith, George Siberry
OBJECTIVES: To identify factors that predispose HIV-exposed uninfected infants (HEUs) to higher incidence of severe infections, hospitalization and death in the first 6 to 24 months of life compared with HEUs with and without lower respiratory tract infection (LRTI) in the first 6 months of life. DESIGN: Nested case-control study of 107 LRTI+ infants enrolled in the NISDI Perinatal and LILAC studies with and 140 LRTI- in the first 6 months of, matched by date and place of birth...
March 18, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29619872/association-of-short-term-blood-pressure-variability-with-cardiovascular-mortality-among-incident-hemodialysis-patients
#9
Yiduo Feng, Ziqian Li, Jing Liu, Fang Sun, Lijie Ma, Yang Shen, Yilun Zhou
OBJECTIVE: To investigate the association of short-term blood pressure variability (BPV) with cardiovascular mortality in hemodialysis (HD) patients, using a reliable index called average real variability (ARV), and to assess the factors associated with ARV in incident HD population. METHODS: A total of 103 HD patients were recruited, with 44-h ambulatory blood pressure monitoring performed after the midweek HD session. Systolic BPV was assessed by SD, coefficient of variation (CV), and ARV, respectively...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29619436/concomitant-sexually-transmitted-diseases-in-patients-with-diagnosed-hiv-aids-a-retrospective-study
#10
Densy Violina Harnanti, Afif Nurul Hidayati, Muhammad Miftahussurur
Background: Human immunodeficiency virus (HIV) is a virus that causes Acquired Immunodeficiency Syndrome (AIDS) which weaken the human immune system and thus increasing the incidence of sexually transmitted infections (STIs) and vice versa. Materials and Methods: A retrospective study of STIs in HIV/AIDS patients in Unit Perawatan Intermediate Penyakit Infeksi (UPIPI) Dr. Soetomo General Hospital Surabaya was conducted from January 1st, 2013 to December 31st, 2014...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29618330/filaria-specific-antibody-response-profiling-in-plasma-from-anti-retroviral-na%C3%A3-ve-loa-loa-microfilaraemic-hiv-1-infected-people
#11
Ghislain Donald Njambe Priso, Abel Lissom, Loveline N Ngu, Nadesh N Nji, Jules Colince Tchadji, Thibau Flaurant Tchouangueu, Georgia E Ambada, Carole Stéphanie Sake Ngane, Brigitte Laure Dafeu, Larissa Djukouo, Inès Nyebe, Suzanne Magagoum, Apeh Alfred Ngoh, Ouambo Fotso Herve, Rosario Garcia, Anna Gutiérrez, Arinze S Okoli, Charles O Esimone, Flobert Njiokou, Chae Gyu Park, Alain Bopda Waffo, Godwin W Nchinda
BACKGROUND: In West and Central Africa areas of endemic Loa loa infections overlap with regions of high prevalence of human immunodeficiency virus type 1 (HIV-1) infections. Because individuals in this region are exposed to filarial parasites from birth, most HIV-1 infected individuals invariably also have a history of filarial parasite infection. Since HIV-1 infection both depletes immune system and maintains it in perpetual inflammation, this can hamper Loa loa filarial parasite mediated immune modulation, leading to enhanced loaisis...
April 4, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29607652/stable-caloric-intake-and-continued-virologic-suppression-for-hiv-positive-antiretroviral-treatment-experienced-women-after-switching-to-a-single-tablet-regimen-of-emtricitabine-rilpivirine-and-tenofovir-disoproxil-fumarate
#12
Prema Menezes, Katie Mollan, Erin Hoffman, Zimeng Xie, Jennifer Wills, Cheryl Marcus, John Rublein, Michael Hudgens, Joseph J Eron
BACKGROUND: Benefits of switching to a single-tablet regimen (STR) of FTC/RPV/TDF in virologically suppressed antiretroviral treatment experienced HIV-positive women include pregnancy category B rating and lack of clinically significant drug interactions between RPV and oral contraceptives. Unfortunately, studies involving switching to FTC/RPV/TDF enrolled fewer than 25% women. We undertook this 48 week study to assess the ability of virologically suppressed HIV-positive women switching to RPV STR to remain virologically suppressed and comply with the caloric intake requirement...
April 1, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29584723/transmission-of-hiv-1-drug-resistance-mutations-within-partner-pairs-a-cross-sectional-study-of-a-primary-hiv-infection-cohort
#13
Joanne D Stekler, Ross Milne, Rachel Payant, Ingrid Beck, Joshua Herbeck, Brandon Maust, Wenjie Deng, Kenneth Tapia, Sarah Holte, Janine Maenza, Claire E Stevens, James I Mullins, Ann C Collier, Lisa M Frenkel
BACKGROUND: Transmission of human immunodeficiency virus type 1 (HIV-1) drug resistance mutations, particularly that of minority drug-resistant variants, remains poorly understood. Population-based studies suggest that drug-resistant HIV-1 is less transmissible than drug-susceptible viruses. We compared HIV-1 drug-resistant genotypes among partner-pairs in order to assess the likelihood of transmission of drug resistance mutations and investigate the role of minority variants in HIV transmission...
March 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29579247/reduced-fecundity-in-hiv-positive-women
#14
A Gemmill, S E K Bradley, S van der Poel
STUDY QUESTION: Is HIV associated with increased time to pregnancy (TTP)? SUMMARY ANSWER: HIV-positive women who discontinue a contraceptive method to become pregnant have increased TTP, particularly among those who likely do not know their status. WHAT IS KNOWN ALREADY: HIV-positive women have fewer children on average than their HIV-negative counterparts due to both behavioral and biological factors. There is a need to better describe and quantify fecundity patterns associated with HIV in the general population...
March 20, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29568194/analytical-method-development-and-validation-for-the-simultaneous-estimation-of-abacavir-and-lamivudine-by-reversed-phase-high-performance-liquid-chromatography-in-bulk-and-tablet-dosage-forms
#15
Sufiyan Ahmad Raees Ahmad, Lalit Patil, Mohammed Rageeb Mohammed Usman, Mohammad Imran, Rashid Akhtar
Objective: A simple rapid, accurate, precise, and reproducible validated reverse phase high performance liquid chromatography (HPLC) method was developed for the determination of Abacavir (ABAC) and Lamivudine (LAMI) in bulk and tablet dosage forms. Methods: The quantification was carried out using Symmetry Premsil C18 (250 mm × 4.6 mm, 5 μm) column run in isocratic way using mobile phase comprising methanol: water (0.05% orthophosphoric acid with pH 3) 83:17 v/v and a detection wavelength of 245 nm and injection volume of 20 μl, with a flow rate of 1 ml/min...
January 2018: Pharmacognosy Research
https://www.readbyqxmd.com/read/29566724/utilization-of-prevention-of-mother-to-child-transmission-pmtct-services-among-pregnant-women-in-hiv-care-in-uganda-a-24-month-cohort-of-women-from-pre-conception-to-post-delivery
#16
Rhoda K Wanyenze, Kathy Goggin, Sarah Finocchario-Kessler, Jolly Beyeza-Kashesya, Deborah Mindry, Josephine Birungi, Mahlet Woldetsadik, Glenn J Wagner
OBJECTIVE: We assessed the uptake of prevention of mother-to-child transmission (PMTCT) services in a cohort of HIV infected women in care at The AIDS Support Organization Jinja and Kampala in Uganda, who were trying to conceive, over a period of 24 months, to inform the strengthening of PMTCT service access for women in care. RESULTS: Of the 299 women 127 (42.5%) reported at least one pregnancy within 24 months; 61 women (48.0%) delivered a live child. Of the 55 who had a live birth at the first pregnancy, 54 (98...
March 22, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29562847/oral-provocation-testing-in-cutaneous-adverse-drug-reactions-to-antiretroviral-and-antitubercular-therapy-a-study-at-a-tertiary-care-hospital-in-south-india
#17
Sowmya Kaimal, Jithendriya Madhukara
AIM: To collect data pertaining to oral drug provocation testing (DPT) in hospitalized patients with antiretroviral (ARV)/antitubercular agent-induced rashes. METHODS: Patients with cutaneous adverse drug reactions (ADRs) to ARV/antitubercular drugs and who underwent oral DPT during a 5-year period were included in this study. RESULTS: Data were collected from the records of 21 patients. Of the 21, 19 had HIV infection. The most commonly implicated drug was nevirapine (NVP), followed by cotrimoxazole and antitubercular agents...
January 2018: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/29550446/access-to-hepatitis-c-virus-treatment-lessons-from-implementation-of-strategies-for-increasing-access-to-antiretroviral-treatment
#18
Yibeltal Assefa, Peter S Hill, Owain D Williams
At September's 2017 United Nations General Assembly, a state-of-the-art HIV medicine was announced to be made available at just $75 per person per year. There have been a number of strategies that the global AIDS community and countries have utilized to reduce prices and make antiretrovirals (ARVs) accessible for people living with HIV/AIDS. There appears to be an opportunity for the treatment of hepatitis C virus infection using direct-acting antivirals (DAAs) to benefit from the often painful and laboured history of driving down the prices of ARVs...
March 14, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29547440/global-hiv-neurology-a-comprehensive-review
#19
Kiran T Thakur, Alexandra Boubour, Deanna Saylor, Mitashee Das, David R Bearden, Gretchen L Birbeck
: Neurological conditions associated with HIV remain major contributors to morbidity and mortality and are increasingly recognized in the aging population on long-standing combination antiretroviral therapy (cART). Importantly, growing evidence shows that the CNS may serve as a reservoir for viral replication, which has major implications for HIV eradication strategies. Though there has been major progress in the last decade in our understanding of the pathogenesis, burden, and impact of neurological conditions associated with HIV infection, significant scientific gaps remain...
March 15, 2018: AIDS
https://www.readbyqxmd.com/read/29537654/the-cost-effectiveness-of-multi-purpose-hiv-and-pregnancy-prevention-technologies-in-south-africa
#20
Matthew Quaife, Fern Terris-Prestholt, Robyn Eakle, Maria A Cabrera Escobar, Maggie Kilbourne-Brook, Mercy Mvundura, Gesine Meyer-Rath, Sinead Delany-Moretlwe, Peter Vickerman
INTRODUCTION: A number of antiretroviral HIV prevention products are efficacious in preventing HIV infection. However, the sexual and reproductive health needs of many women extend beyond HIV prevention, and research is ongoing to develop multi-purpose prevention technologies (MPTs) that offer dual HIV and pregnancy protection. We do not yet know if these products will be an efficient use of constrained health resources. In this paper, we estimate the cost-effectiveness of combinations of candidate multi-purpose prevention technologies (MPTs), in South Africa among general population women and female sex workers (FSWs)...
March 2018: Journal of the International AIDS Society
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