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https://www.readbyqxmd.com/read/28081037/higher-cd163-levels-are-associated-with-insulin-resistance-in-hepatitis-c-virus-infected-and-hiv-infected-adults
#1
Michael Reid, Yifei Ma, Rebecca Scherzer, Jennifer C Price, Audrey L French, Michael W Plankey, Carl Grunfeld, Phyllis C Tien
OBJECTIVES: HIV/hepatitis C virus (HCV) coinfection is associated with insulin resistance, but the mechanism is unclear. We hypothesized that intestinal epithelial damage and the consequent monocyte/macrophage activation and inflammation explain this perturbation. DESIGN: Cross-sectional study of 519 adults (220 HIV+/HCV-; 64 HIV-/HCV+; 89 HIV+/HCV+; 146 HIV-/HCV-). METHODS: We used multivariable linear regression to evaluate associations of HIV and HCV with the homeostasis model assessment of insulin resistance (HOMA-IR) and if intestinal fatty (FA) acid binding protein (I-FABP, a marker of gut epithelial integrity), soluble CD14 (sCD14) and soluble CD163 (sCD163) (markers of monocyte/macrophage activation), and IL-6 (an inflammatory cytokine) mediated this association...
January 28, 2017: AIDS
https://www.readbyqxmd.com/read/28067719/insulin-resistance-and-markers-of-inflammation-in-hiv-infected-ugandan-children-in-the-chapas-3-trial
#2
Sahera Dirajlal-Fargo, Victor Musiime, Adrian Cook, Grace Mirembe, Julia Kenny, Ying Jiang, Sara Debanne, Nigel Klein, Grace A Mccomsey
BACKGROUND: Few studies have investigated metabolic complications in HIV-infected African children and their relation with inflammation. METHODS: We compared baseline and changes in insulin resistance (HOMA-IR) and in markers of inflammation over 48 weeks, in a subset of antiretroviral therapy (ART) naïve Ugandan children from the CHAPAS-3 trial randomized to zidovudine (AZT), stavudine (D4T) or abacavir (ABC) based regimens. Non-parametric methods were used to explore between and within group differences and multivariable analyses to assess associations of HOMA-IR...
January 6, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28066794/altered-monocyte-and-endothelial-cell-adhesion-molecule-expression-is-linked-to-vascular-inflammation-in-human-immunodeficiency-virus-infection
#3
Manjusha Kulkarni, Emily Bowman, Janelle Gabriel, Taylor Amburgy, Elizabeth Mayne, David A Zidar, Courtney Maierhofer, Abigail Norris Turner, Jose A Bazan, Susan L Koletar, Michael M Lederman, Scott F Sieg, Nicholas T Funderburg
BACKGROUND: Human immunodeficiency virus (HIV)-infected individuals have increased risk for vascular thrombosis, potentially driven by interactions between activated leukocytes and the endothelium. METHODS: Monocyte subsets (CD14(+)CD16(-), CD14(+)CD16(+), CD14(Dim)CD16(+)) from HIV negative (HIV(-)) and antiretroviral therapy-treated HIV positive (HIV(+)) participants (N = 19 and 49) were analyzed by flow cytometry for adhesion molecule expression (lymphocyte function-associated antigen 1 [LFA-1], macrophage-1 antigen [Mac-1], CD11c/CD18, very late antigen [VLA]-4) and the fractalkine receptor (CX3CR1); these receptors recognize ligands (intercellular adhesion molecules [ICAMs], vascular cell adhesion molecule [VCAM]-1, fractalkine) on activated endothelial cells (ECs) and promote vascular migration...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28046096/early-antiretroviral-therapy-is-associated-with-lower-hiv-dna-molecular-diversity-and-lower-inflammation-in-cerebrospinal-fluid-but-does-not-prevent-the-establishment-of-compartmentalized-hiv-dna-populations
#4
Michelli F Oliveira, Antoine Chaillon, Masato Nakazawa, Milenka Vargas, Scott L Letendre, Matthew C Strain, Ronald J Ellis, Sheldon Morris, Susan J Little, Davey M Smith, Sara Gianella
Even when antiretroviral therapy (ART) is started early after infection, HIV DNA might persist in the central nervous system (CNS), possibly contributing to inflammation, brain damage and neurocognitive impairment. Paired blood and cerebrospinal fluid (CSF) were collected from 16 HIV-infected individuals on suppressive ART: 9 participants started ART <4 months of the estimated date of infection (EDI) ("early ART"), and 7 participants started ART >14 months after EDI ("late ART"). For each participant, neurocognitive functioning was measured by Global Deficit Score (GDS)...
January 3, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/27984415/a-cytokine-pattern-that-differentiates-pre-from-post-seroconversion-phases-of-primary-hiv-infection
#5
Lucia Pastor, Erica Parker, Jorge Carrillo, Victor Urrea, Laura Fuente-Soro, Durval Respeito, Chenjerai Jairoce, Inacio Mandomando, Julià Blanco, Denise Naniche
BACKGROUND: During acute HIV infection (AHI) HIV actively replicates but seroconversion has not yet occurred. Primary HIV infection (PHI) is characterized by a transient non-specific febrile illness, a massive inflammatory response and the progressive appearance of anti-HIV specific antibodies. In this study we have identified patterns of inflammatory biomarkers associated with the innate immunological reaction prior to completion of a full humoral response. METHODS: A symptom-based screening was used to identify AHI in the Manhiça District Hospital in Mozambique...
8, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27960133/increased-serum-levels-of-macrophage-activation-marker-scd163-in-dengue-patients
#6
Sarayu Gopal S S, Agieshkumar B Pillai, Vijayakumar Shettikothanuru Ramachandrappa, Kadhiravan T, Rahul Dhodapkar, James Kah, Soundravally Rajendiran
BACKGROUND: Dengue viruses are known to infect and replicate in macrophages. Thus studying the host responsive molecules that are specifically released by macrophages during the course of dengue infection may provide better understanding on dengue immunopathogenesis. Soluble CD163 (sCD163) is a scavenger receptor, highly expressed on macrophages reported to be involved in some viral disease. The participation of sCD163 in dengue is not known. OBJECTIVE: The present study aimed to explore the role of sCD163 as a potential biomarker for predicting dengue disease...
January 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27922852/hiv-associated-changes-in-the-enteric-microbial-community-potential-role-in-loss-of-homeostasis-and-development-of-systemic-inflammation
#7
David B Gootenberg, Jeffrey M Paer, Jesus-Mario Luevano, Douglas S Kwon
PURPOSE OF REVIEW: Despite HIV therapy advances, average life expectancy in HIV-infected individuals on effective treatment is significantly decreased relative to uninfected persons, largely because of increased incidence of inflammation-related diseases, such as cardiovascular disease and renal dysfunction. The enteric microbial community could potentially cause this inflammation, as HIV-driven destruction of gastrointestinal CD4 T cells may disturb the microbiota-mucosal immune system balance, disrupting the stable gut microbiome and leading to further deleterious host outcomes...
February 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27880829/interleukin-15-il-15-strongly-correlates-with-increasing-hiv-1-viremia-and-markers-of-inflammation
#8
Sanjay Swaminathan, Ju Qiu, Adam W Rupert, Zonghui Hu, Jeanette Higgins, Robin L Dewar, Randy Stevens, Catherine A Rehm, Julia A Metcalf, Brad T Sherman, Michael W Baseler, H Clifford Lane, Tomozumi Imamichi
OBJECTIVE: IL-15 has been postulated to play an important role in HIV-1 infection, yet there are conflicting reports regarding its expression levels in these patients. We sought to measure the level of IL-15 in a large, well characterised cohort of HIV-1 infected patients and correlate this with well known markers of inflammation, including CRP, D-dimer, sCD163 and sCD14. DESIGN AND METHODS: IL-15 levels were measured in 501 people (460 patients with HIV-1 infection and 41 uninfected controls)...
2016: PloS One
https://www.readbyqxmd.com/read/27870882/immune-activation-at-sites-of-hiv-tb-co-infection-contributes-to-the-pathogenesis-of-hiv-1-disease
#9
Qinglai Meng, Ismail Sayin, David H Canaday, Harriet Mayanja-Kizza, Joy Baseke, Zahra Toossi
Systemic immune activation is critical to the pathogenesis of HIV-1 disease, and is accentuated in HIV/TB co-infected patients. The contribution of immune activation at sites of HIV/TB co-infection to viral activity, CD4 T cell count, and productive HIV-1 infection remain unclear. In this study, we measured markers of immune activation both in pleural fluid and plasma, and in T cells in pleural fluid mononuclear cell (PFMC) and peripheral blood mononuclear cell (PBMC) in HIV/TB co-infected subjects. The relationship between soluble and T cell activation markers with viral load in pleural fluid and blood CD4 T cell count were assessed...
2016: PloS One
https://www.readbyqxmd.com/read/27828874/soluble-cd163-in-cmv-infected-and-uninfected-subjects-on-virologically-suppressive-antiretroviral-therapy-in-the-icona-cohort
#10
Serena Vita, Miriam Lichtner, Giulia Marchetti, Claudia Mascia, Esther Merlini, Paola Cicconi, Vincenzo Vullo, Pierluigi Viale, Andrea Costantini, Antonella DʼArminio Monforte
AIMS: To contribute to the understanding of the role played by CMV in sustaining monocyte/macrophage-mediated immune activation in ART treated HIV infected subjects. DESIGN: and Methods: We selected 23 CMV-uninfected and 46 CMV-infected HIV+ subjects, matched for age, CD4 nadir, HIV infection duration, viral hepatitis serostatus. All subjects were on successful ART since at least 1 year. A group of 16 healthy donors with similar age and sex was also included. Plasma levels of TNF-α, IL-6, sCD163, sCD14 and CMV IgG levels were measured in duplicate with human ELISA kits...
November 4, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27789726/monocyte-activation-is-associated-with-worse-cognitive-performance-in-hiv-infected-women-with-virologic-suppression
#11
Brandon M Imp, Leah H Rubin, Phyllis C Tien, Michael W Plankey, Elizabeth T Golub, Audrey L French, Victor G Valcour
BACKGROUND:  Cognitive impairment persists despite suppression of plasma human immunodeficiency virus (HIV) RNA. Monocyte-related immune activation is a likely mechanism. We examined immune activation and cognition in a cohort of HIV-infected and uninfected women from the Women's Interagency HIV Study (WIHS). METHODS:  Blood levels of activation markers, soluble CD163 (sCD163), soluble CD14 (sCD14), CRP, IL-6, and a gut microbial translocation marker (intestinal fatty acid binding protein (I-FABP)) were measured in 253 women (73% HIV-infected)...
January 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27742226/equivalent-decline-in-inflammation-markers-with-tenofovir-disoproxil-fumarate-vs-tenofovir-alafenamide
#12
Nicholas T Funderburg, Grace A McComsey, Manjusha Kulkarni, Tammy Bannerman, Jessica Mantini, Bernadette Thornton, Hui C Liu, Yafeng Zhang, Qinghua Song, Liang Fang, Jason Dinoso, Andrew Cheng, Scott McCallister, Marshall W Fordyce, Moupali Das
BACKGROUND: Initiation of antiretroviral therapy (ART) and subsequent virologic suppression reduces immune activation and systemic inflammation. METHODS: We examined longitudinal changes in biomarkers of monocyte activation (sCD14, sCD163), and systemic (IL-6, hsCRP, sTNFR-I and D-dimer) and vascular (Lp-PLA2) inflammation in a subgroup (N=100 per arm) of participants enrolled in a randomized, placebo-controlled trial comparing elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF; TAF) to E/C/F/tenofovir disoproxil fumarate (E/C/F/TDF; TDF) in treatment-naïve adults...
November 2016: EBioMedicine
https://www.readbyqxmd.com/read/27733938/serum-soluble-cd163-and-its-association-with-various-disease-parameters-in-patients-with-systemic-sclerosis
#13
Waleed Ahmed Salah Eldeen Hassan, Eman Abd Elaleem Baraka, Basant Mohammed Elnady, Tahany Mahmoud Gouda, Nehad Fouad
OBJECTIVE: Cluster of differentiation 163 (CD163) is a receptor that binds haptoglobin-hemoglobin complexes and is mainly expressed on macrophages and monocytes. As a result of shedding, the extracellular portion of CD163 circulates in the blood as a soluble CD163 (sCD163). This study aimed to measure serum sCD163 levels in patients with systemic sclerosis (SSc) and to assess its association with the clinical, laboratory, and radiological features of the disease. MATERIAL AND METHODS: We measured serum sCD163 levels in 24 patients with SSc and in 30 healthy controls...
September 2016: Eur J Rheumatol
https://www.readbyqxmd.com/read/27725129/glucocorticoid-receptor-haplotypes-conferring-increased-sensitivity-bcli-and-n363s-are-associated-with-faster-progression-of-multiple-sclerosis
#14
Jeroen Melief, Jan W Koper, Erik Endert, Holger J Møller, Jörg Hamann, Bernard M Uitdehaag, Inge Huitinga
As high cortisol levels are implicated in suppressed disease activity of multiple sclerosis (MS), glucocorticoid receptor (GR) polymorphisms that affect glucocorticoid (GC) sensitivity may impact on this by changing local immunomodulation or regulation of the hypothalamus-pituitary-adrenal (HPA)-axis. In this post-mortem study, we investigated whether GR haplotypes affect MS disease course and production of cortisol and soluble CD163 (sCD163), a molecule induced by GC on microglia/macrophages. We found that GR haplotypes that confer high GC sensitivity are associated with more aggressive MS but do not affect levels of cortisol secreted by the HPA-axis or shedding of CD163...
October 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27688939/a-multi-biomarker-follow-up-study-of-patients-with-multiple-sclerosis
#15
Morten Stilund, Mikkel Carstensen Gjelstrup, Tove Christensen, Holger Jon Møller, Thor Petersen
OBJECTIVES: This study aimed to examine the levels of the macrophage marker sCD163 and other biomarkers at the time of diagnosis of patients with either clinically isolated syndrome (CIS) or relapsing-remitting multiple sclerosis (RRMS), and assess relation to clinical indicators of prognosis, disease activity (DA), and changes in the levels of these biomarkers at follow-up. MATERIALS AND METHODS: The clinical status and MRI were reevaluated in 56 patients more than 1 year after diagnosis with a median follow-up time of 2 years...
September 2016: Brain and Behavior
https://www.readbyqxmd.com/read/27685837/cd163-levels-pro-and-anti-inflammatory-cytokine-secretion-of-monocytes-in-children-with-pulmonary-tuberculosis
#16
Esin Aktas Cetin, Leyla Pur Ozyigit, Yusuf Metin Gelmez, Erkan Cakir, Ahmet Hakan Gedik, Gunnur Deniz
OBJECTIVES: Childhood tuberculosis (TB) comprises an important part of the world's TB burden. Monocytes set up the early phase of infection because of innate immune responses. Understanding the changes in monocyte subsets during multisystem infectious diseases may be important for the development of novel diagnostic and therapeutic strategies. The aim of this study was to evaluate the monocyte phenotype together with the cytokine secretion profiles of children with pulmonary tuberculosis...
September 29, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27684274/utility-of-macrophage-activated-marker-cd163-for-diagnosis-and-prognosis-in-pulmonary-tuberculosis
#17
Yuzo Suzuki, Masahiro Shirai, Kazuhiro Asada, Seiichi Miwa, Masato Karayama, Yutaro Nakamura, Naoki Inui, Toshihiro Shirai, Hiroshi Hayakawa, Satoshi Baba, Takafumi Suda
RATIONALE: Among infectious diseases, tuberculosis (TB) is a leading cause of death worldwide. Accumulated knowledge has revealed that macrophages are deeply involved in the progression and pathogenesis of TB. We hypothesized that the evaluation of a macrophage activation marker may be useful in the diagnosis and assessment of pulmonary TB. OBJECTIVES: To examine the utility of the macrophage activation marker soluble CD163 (sCD163) as a diagnostic tool and measure of disease severity for pulmonary TB and tuberculous pleurisy...
January 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27683822/cigarette-smoking-and-inflammation-monocyte-activation-and-coagulation-in-hiv-infected-individuals-receiving-antiretroviral-therapy-compared-with-uninfected-individuals
#18
Katherine W Kooij, Ferdinand W N M Wit, Thijs Booiman, Marc van der Valk, Maarten F Schim van der Loeff, Neeltje A Kootstra, Peter Reiss
Smoking may affect cardiovascular disease risk more strongly in human immunodeficiency virus (HIV)-infected individuals than HIV-uninfected individuals. We hypothesized that an interaction at the level of the immune system may contribute to this increased risk. We assessed soluble markers of inflammation (high-sensitivity C-reactive protein [hsCRP]), immune activation (soluble [s]CD14 and sCD163), and coagulation (D-dimer) in HIV-infected and uninfected never, former, and current smokers. Smoking was independently associated with higher hsCRP levels and lower sCD163 levels and was borderline significantly associated with higher sCD14 and D-dimer levels...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27679428/single-centre-experience-of-the-macrophage-activation-marker-soluble-s-cd163-associations-with-disease-activity-and-treatment-response-in-patients-with-autoimmune-hepatitis
#19
H Grønbaek, M Kreutzfeldt, K Kazankov, N Jessen, T Sandahl, S Hamilton-Dutoit, H Vilstrup, H J Møller
BACKGROUND: Autoimmune hepatitis (AIH) is characterised by liver inflammation with reversibility upon anti-inflammatory treatment. Soluble (s)CD163, a specific macrophage activation marker, is associated with inflammation in other liver diseases, but never investigated in AIH. AIM: To investigate sCD163 in patients with acute AIH and in complete and incomplete responders to standard anti-inflammatory pharmacotherapy, and during follow-up in treatment naive patients...
November 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27615375/decreased-pd-1-expression-on-cd8-lymphocyte-subsets-and-increase-in-cd8%C3%A2-tscm-cells-in-children-with-hiv-receiving-raltegravir
#20
Florin Tuluc, Sergei Spitsin, Nancy B Tustin, Jennifer B Murray, Richard Tustin, Laura A Schankel, Andrew Wiznia, Sharon Nachman, Steven D Douglas
We investigated the effect of combination antiretroviral therapy (cART) on immune recovery, particularly on the percentages of PD-1-positive cells within the major leukocyte subsets. Cryopreserved peripheral blood mononuclear cells and plasma samples collected longitudinally from a subset of 13 children and adolescents (between 9.7 and 18.2 years old) who were enrolled in the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1066 were used for this study. Immunophenotyping by flow cytometry was performed to determine the effect of raltegravir-containing cART regimen on the distribution of leukocyte populations, on the expression of PD-1 on T cell subpopulations, and on the expression of well-established markers of T cell activation (CD38 and HLA-DR) on CD8 T cells...
October 18, 2016: AIDS Research and Human Retroviruses
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