keyword
MENU ▼
Read by QxMD icon Read
search

Scd163

keyword
https://www.readbyqxmd.com/read/29303843/cognition-emotional-health-and-immunological-markers-in-children-with-long-term-nonprogressive-hiv
#1
Robert Paul, Tanakorn Apornpong, Wasana Prasitsuebsai, Thanyawee Puthanakit, Vonthanak Saphonn, Linda Aurpibul, Pope Kosalaraksa, Suparat Kanjanavanit, Wicharn Luesomboon, Chaiwat Ngampiyaskul, Tulathip Suwanlerk, Kea Chettra, William T Shearer, Victor Valcour, Jintanat Ananworanich, Stephen Kerr
BACKGROUND: HIV-infected children with long-term nonprogressive disease (LTNPs) eventually convert to a progressive disease type, yet the extent to which these children experience the cognitive and emotional symptoms observed in typical progressive HIV (Progressors) is unknown. METHODS: Eighty-eight LTNPs, 53 Progressors, and 323 healthy controls completed annual assessments of cognitive and emotional health as part of a prospective study. The two HIV-infected groups and the healthy controls were matched on age and sex distribution at enrollment...
January 4, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29299802/hcv-coinfection-of-the-hiv-infected-patients-with-discordant-cd4-t-cell-response-to-antiretroviral-therapy-leads-to-intense-systemic-inflammation
#2
K V Shmagel, L B Korolevskaya, E V Saidakova, N G Shmagel, V A Chereshnev, L Margolis, D Anthony, M Lederman
The level of proinflammatory markers was assessed in HIV-infected patients that were coinfected with hepatitis C virus (HCV) and had failed to restore the CD4+ T cell counts (immunological nonresponders, INR) during the antiretroviral therapy (ART). Among four patient groups (HIV+HCV- and HIV+HCV+ subjects with the concordant response to ART; HIV+HCV- and HIV+HCV+ subjects that were INR), the greatest systemic inflammation was in the latter group. The maximum difference was between the subjects HIV+HCV-INR and HIV+HCV+ INR: the blood of coinfected patients contained significantly higher concentrations of the IP-10, sCD163, sTNF-RI, and sTNF-RII and of bacterial lipopolysaccharide...
November 2017: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/29295869/macrophage-activation-marker-scd163-correlates-with-accelerated-lipolysis-following-lps-exposure-a-human-randomised-clinical-trial
#3
Nikolaj Rittig, Mads Svart, Niels Jessen, Niels Møller, Holger J Møller, Henning Grønbæk
BACKGROUND: Macrophage activation determined by levels of soluble sCD163 is associated with obesity, insulin resistance, diabetes mellitus type 2 (DM2) and non-alcoholic fatty liver disease (NAFLD). This suggests that macrophage activation is involved in the pathogenesis of conditions is characterised by adaptions in the lipid metabolism. Since sCD163 is shed to serum by inflammatory signals including lipopolysaccharides (LPS, endotoxin), we investigated sCD163 and correlations with lipid metabolism following LPS exposure...
January 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29226690/low-levels-of-endothelial-progenitor-cells-and-their-association-with-systemic-inflammation-and-monocyte-activation-in-older-hiv-infected-men
#4
Sophie Seang, Theodoros Kelesidis, Diana Huynh, Sangeun Park, Ardis Moe, Judith Currier, Jordan E Lake
BACKGROUND: Endothelial progenitor cells (EPCs) repair damaged vascular endothelium and low circulating EPC levels have been associated with cardiovascular disease (CVD). CD34+/KDR+ EPCs are commonly reported in literature and CD34+/CD133+/KDR+ EPCs are rare in circulation but highly specific for endothelial lineage. HIV-infected (HIV+) adults have chronic inflammation and increased CVD risk, but the relationship between CVD, vascular inflammation and EPCs in HIV remains unclear. METHODS: In a pilot study, EPCs were measured in 57 HIV+ men (≧50 years old, HIV-1 RNA <50 copies/mL on ART) by real-time flow cytometry using cellular immaturity (CD34 and/or CD133) and endothelial commitment (KDR) markers...
December 10, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29226174/proprotein-convertase-subtilisin-kexin-9-levels-in-relation-to-systemic-immune-activation-and-subclinical-coronary-plaque-in-hiv
#5
Markella V Zanni, Lauren A Stone, Mabel Toribio, Dodie E Rimmelin, Jake Robinson, Tricia H Burdo, Kenneth Williams, Kathleen V Fitch, Janet Lo, Steven K Grinspoon
Background: Proprotein convertase subtilisin/kexin 9 (PCSK9) is known to mediate homeostasis of low-density lipoprotein cholesterol (LDL-c), but it may also participate in immune reactivity and atherogenesis. Methods: We compared circulating PCSK9 levels among asymptomatic individuals with and without HIV. Further, within each group, we assessed the relationship between PCSK9 levels, traditional cardiovascular disease risk factors, immune activation, and subclinical coronary atherosclerotic plaque...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29191820/monocyte-alterations-in-rheumatoid-arthritis-are-dominated-by-preterm-release-from-bone-marrow-and-prominent-triggering-in-the-joint
#6
Biljana Smiljanovic, Anna Radzikowska, Ewa Kuca-Warnawin, Weronika Kurowska, Joachim R Grün, Bruno Stuhlmüller, Marc Bonin, Ursula Schulte-Wrede, Till Sörensen, Chieko Kyogoku, Anne Bruns, Sandra Hermann, Sarah Ohrndorf, Karlfried Aupperle, Marina Backhaus, Gerd R Burmester, Andreas Radbruch, Andreas Grützkau, Wlodzimierz Maslinski, Thomas Häupl
OBJECTIVE: Rheumatoid arthritis (RA) accompanies infiltration and activation of monocytes in inflamed joints. We investigated dominant alterations of RA monocytes in bone marrow (BM), blood and inflamed joints. METHODS: CD14+ cells from BM and peripheral blood (PB) of patients with RA and osteoarthritis (OA) were profiled with GeneChip microarrays. Detailed functional analysis was performed with reference transcriptomes of BM precursors, monocyte blood subsets, monocyte activation and mobilisation...
November 30, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29174692/increased-serum-production-of-soluble-cd163-and-cxcl5-in-patients-with-moyamoya-disease-involvement-of-intrinsic-immune-reaction-in-its-pathogenesis
#7
Miki Fujimura, Taku Fujimura, Aya Kakizaki, Mika Sato-Maeda, Kuniyasu Niizuma, Yasutake Tomata, Setsuya Aiba, Teiji Tominaga
Moyamoya disease (MMD) is a rare cerebrovascular disease characterized by a progressive stenosis at the terminal portion of the internal carotid artery and an abnormal vascular network at the base of the brain. Although its etiology is still unknown, intrinsic immune reactions such as autoimmune response has been implicated in the pathogenesis of MMD. Recently, the RING finger protein 213 (RNF213) was found to be an important risk gene for MMD, and is predominantly expressed in blood cells and the spleen. Thus, we hypothesized that patients with MMD represent an intrinsic autoimmune status mediated by M2-polarized macrophages, which play an important role in tissue remodeling and angiogenesis...
November 22, 2017: Brain Research
https://www.readbyqxmd.com/read/29159191/soluble-cd163-in-intracerebral-hemorrhage-biomarker-for-perihematomal-edema
#8
Meaghan Roy-O'Reilly, Liang Zhu, Louise Atadja, Glenda Torres, Jaroslaw Aronowski, Louise McCullough, Nancy J Edwards
Objective: Patients with intracerebral hemorrhage (ICH) may elaborate varying degrees of perihematomal edema (PHE), requiring closer monitoring and a higher intensity of treatment. Here, we explore whether the soluble form of CD163, a scavenger receptor responsible for hemoglobin sequestration, can serve as a prognostic biomarker of PHE development and poor outcome after ICH. Methods: Our study cohort was comprised of 51 primary age- and sex-matched ICH patients with moderate-sized, hypertensive deep hemorrhages...
November 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29077674/macrophage-activation-and-the-tumor-necrosis-factor-cascade-in-hepatitis-c-disease-progression-among-hiv-infected-women-participating-in-the-women-s-interagency-hiv-study
#9
Audrey L French, Jonathan W Martin, Charlesnika T Evans, Marion Peters, Seble G Kessaye, Marek Nowicki, Mark Kuniholm, Elizabeth Golub, Michael Augenbraun, Seema N Desai
BACKGROUND: HIV/hepatitis C-coinfected persons experience more rapid liver disease progression than hepatitis C virus (HCV) monoinfected persons, even in the setting of potent antiretroviral therapy. METHODS: We sought to articulate the role of macrophage activation and inflammation in liver disease progression by measuring serial soluble markers in HIV/HCV-coinfected women. We compared markers measured during retrospectively defined periods of rapid liver disease progression to periods where little or no liver disease progression occurred...
December 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28991699/microglial-macrophage-markers-chi3l1-scd14-and-scd163-in-csf-and-serum-of-pediatric-inflammatory-and-non-inflammatory-neurological-disorders-a-case-control-study-and-reference-ranges
#10
Michael R Pranzatelli, Elizabeth D Tate, Nathan R McGee
OBJECTIVE: To assess the role of microglia and macrophages in neuroinflammatory disorders in children via biomarkers, and establish control reference ranges. METHODS: In an IRB-approved case-control study of 98 children, the concentrations of CSF/serum CHI3L1, sCD14, and sCD163 were measured by ELISA. Groups were controls (non-inflammatory neurological disorders, NIND, n=37), opsoclonus-myoclonus syndrome (OMS, n=37), and other inflammatory neurological disorders (OIND, n=24)...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28991044/mountain-cycling-ultramarathon-impacts-in-inflammatory-and-hemoglobin-responses
#11
Isanete Alonso, Andreia Matos, Ricardo Ribeiro, Ângela Gil, Carlos Cardoso, Luís B Sardinha, Manuel Bicho
PURPOSE: To analyze the cumulative physiological burden of repetitive, strenuous exercise held during mountain cycling ultramarathon on regulatory mechanisms of hemoglobin degradation. METHODS: Fifty-five non-professional athletes (mean age 44.8±7.1 years old) participating in a 9-consecutive-day mountain cycling ultramarathon (TransPortugal), underwent anthropometric, hematological and biochemical assessments before and immediately after the race. Participants were further stratified as completers (9 courses) or non-completers, and divided according to the time they took to complete the race...
October 3, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28930079/epicardial-adipose-tissue-volume-and-cardiovascular-risk-indices-among-asymptomatic-women-with-and-without-hiv
#12
Suman Srinivasa, Michael T Lu, Kathleen V Fitch, Travis R Hallett, Timothy K O'Malley, Lauren A Stone, Amanda Martin, Alexandra J Coromilas, Tricia H Burdo, Virginia A Triant, Janet Lo, Sara E Looby, Tomas G Neilan, Markella V Zanni
BACKGROUND: Mechanisms underlying the heightened myocardial infarction risk among HIV-infected women (versus non-HIV-infected women) remain unclear. Our objectives were to assess epicardial adipose tissue (EAT) volume and its associations among asymptomatic women with and without HIV. METHODS: Fifty-five HIV-infected and 27 non-HIV-infected women without known cardiovascular disease who underwent cardiac CT and metabolic/immune phenotyping were included. EAT volume derived from CT was compared among women with and without HIV, and within-group EAT associations were assessed...
September 20, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28928836/preoperative-serum-macrophage-activated-biomarkers-soluble-mannose-receptor-smr-and-soluble-haemoglobin-scavenger-receptor-scd163-as-novel-markers-for-the-diagnosis-and-prognosis-of-gastric-cancer
#13
Dongbing Ding, Yang Song, Yao Yao, Songbai Zhang
Soluble mannose receptor (sMR) and soluble haemoglobin scavenger receptor (sCD163) are macrophage activation markers which have previously been demonstrated to be increased in patients with inflammation, auto-immunity and malignancies. To investigate the clinical diagnostic and prognostic significance of preoperative serum sMR and sCD163, the present study investigated 143 gastric cancer (GC) patients, 66 subjects with benign gastric disease and 59 healthy controls, using an ELISA assay. Preoperative serum levels of sMR and sCD163 ranged from 0...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28918754/macrophage-activation-like-syndrome-an-immunological-entity-associated-with-rapid-progression-to-death-in-sepsis
#14
Evdoxia Kyriazopoulou, Konstantinos Leventogiannis, Anna Norrby-Teglund, Georgios Dimopoulos, Aikaterini Pantazi, Stylianos E Orfanos, Nikoletta Rovina, Iraklis Tsangaris, Theologia Gkavogianni, Elektra Botsa, Eleftheria Chassiou, Anastasia Kotanidou, Christina Kontouli, Panagiotis Chaloulis, Dimitrios Velissaris, Athina Savva, Jonas-Sundén Cullberg, Karolina Akinosoglou, Charalambos Gogos, Apostolos Armaganidis, Evangelos J Giamarellos-Bourboulis
BACKGROUND: A subanalysis of a randomized clinical trial indicated sepsis survival benefit from interleukin (IL)-1 blockade in patients with features of the macrophage activation-like syndrome (MALS). This study aimed to investigate the frequency of MALS and to develop a biomarker of diagnosis and prognosis. METHODS: Patients with infections and systemic inflammatory response syndrome were assigned to one test cohort (n = 3417) and a validation cohort (n = 1704)...
September 18, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28828963/soluble-tweak-may-predict-carotid-atherosclerosis-in-treated-hiv-infection
#15
Sahera Dirajlal-Fargo, Abdus Sattar, Manjusha Kulkarni, Nicholas Funderburg, Grace A McComsey
BACKGROUND: Soluble Tumor Necrosis Factor Weak Inducer of Apoptosis (sTWEAK) has been proposed as a novel biomarker of cardiovascular disease risk. This study compares levels of sTWEAK, sCD163 and the sCD163/sTWEAK ratio in HIV-infected and uninfected patients and their associations with cardiovascular and inflammatory factors. METHODS: The data for our analysis come from 274 HIV-infected adults and 59 controls. HIV participants were on stable antiretroviral therapy (ART)...
July 2017: HIV Clinical Trials
https://www.readbyqxmd.com/read/28764692/african-swine-fever-virus-infection-in-classical-swine-fever-subclinically-infected-wild-boars
#16
Oscar Cabezón, Sara Muñoz-González, Andreu Colom-Cadena, Marta Pérez-Simó, Rosa Rosell, Santiago Lavín, Ignasi Marco, Lorenzo Fraile, Paloma Martínez de la Riva, Fernando Rodríguez, Javier Domínguez, Llilianne Ganges
BACKGROUND: Recently moderate-virulence classical swine fever virus (CSFV) strains have been proven capable of generating postnatal persistent infection (PI), defined by the maintenance of viremia and the inability to generate CSFV-specific immune responses in animals. These animals also showed a type I interferon blockade in the absence of clinical signs. In this study, we assessed the infection generated in 7-week-old CSFV PI wild boars after infection with the African swine fever virus (ASFV)...
August 1, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28754302/immunometabolic-and-lipidomic-markers-associated-with-the-frailty-index-and-quality-of-life-in-aging-hiv-men-on-antiretroviral-therapy
#17
Hui-Ling Yeoh, Allen C Cheng, Catherine L Cherry, Jacquelyn M Weir, Peter J Meikle, Jennifer F Hoy, Suzanne M Crowe, Clovis S Palmer
Chronic immune activation persists despite antiretroviral therapy (ART) in HIV+ individuals and underpins an increased risk of age-related co-morbidities. We assessed the Frailty Index in older HIV+ Australian men on ART. Immunometabolic markers on monocytes and T cells were analyzed using flow cytometry, plasma innate immune activation markers by ELISA, and lipidomic profiling by mass spectrometry. The study population consisted of 80 HIV+ men with a median age of 59 (IQR, 56-65), and most had an undetectable viral load (92%)...
August 2017: EBioMedicine
https://www.readbyqxmd.com/read/28723708/subclinical-herpesvirus-shedding-among-hiv-1-infected-men-on-antiretroviral-therapy
#18
Arcadio Agudelo-Hernandez, Yue Chen, Arlene Bullotta, William G Buchanan, Cynthia R Klamar-Blain, Luann Borowski, Sharon A Riddler, Charles R Rinaldo, Bernard J C Macatangay
OBJECTIVE: We evaluated the subclinical shedding of six different herpesviruses in antiretroviral drug-treated HIV-positive [HIV(+)] MSM, and determined how this is associated with markers of inflammation and immune activation. METHODS: We obtained blood, semen, throat washing, urine, and stool from 15 antiretroviral-treated HIV-1-infected MSM with CD4 T-cell reconstitution, and 12 age-matched HIV-negative [HIV (-)] MSM from the Multicenter AIDS Cohort Study at four timepoints over 24 weeks to measure DNA levels of cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus 1 and 2, human herpesvirus 6 (HHV6), and HHV8...
September 24, 2017: AIDS
https://www.readbyqxmd.com/read/28715286/effects-of-lifestyle-intervention-on-soluble-cd163-a-macrophage-activation-marker-in-patients-with-non-alcoholic-fatty-liver-disease
#19
Sidsel Rødgaard-Hansen, Alexis St George, Konstantin Kazankov, Adrian Bauman, Jacob George, Henning Grønbæk, Holger Jon Møller
OBJECTIVE: Liver macrophages play an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Soluble CD163 (sCD163), a macrophage-specific biomarker, reflects disease activity in the range of liver diseases. The impact of lifestyle intervention on sCD163 in adult NAFLD patients has not been investigated. MATERIAL AND METHODS: We assessed 126 NAFLD patients participating in a lifestyle intervention study for sCD163 concentrations at baseline, after the three-month intervention period, and at long-term follow-up after 12 and 24 months...
July 17, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28714751/antidepressant-efficacy-of-electroconvulsive-therapy-is-associated-with-a-reduction-of-the-innate-cellular-immune-activity-in-the-cerebrospinal-fluid-in-patients-with-depression
#20
Laura Kranaster, Carolin Hoyer, Suna S Aksay, Jan Malte Bumb, Norbert Müller, Peter Zill, Markus J Schwarz, Alexander Sartorius
OBJECTIVES: A bidirectional link between the antidepressant effects of electroconvulsive therapy (ECT) and the modulation of the immune system has been proposed. To elucidate the interplay between antidepressant treatment and macrophage/microglia activation in humans, we performed a study on the effects of the antidepressant treatment by ECT on markers of macrophage/microglia activation in patients with depression. METHODS: We measured six different markers (IL-6, neopterin, sCD14, sCD163 MIF and MCP1) of macrophage/microglia activation in the cerebrospinal fluid (CSF) and blood of 12 patients with a severe, treatment-resistant depressive episode before and after a course of ECT...
August 9, 2017: World Journal of Biological Psychiatry
keyword
keyword
47169
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"