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https://www.readbyqxmd.com/read/28636775/role-of-the-tumour-necrosis-factor-like-weak-inducer-of-apoptosis-tweak-fibroblast-growth-factor-inducible-14-fn14-axis-in-autoimmune-thyroid-disease
#1
Shiqiao Peng, Xiaohui Yu, Xuemin Zhao, Xinyi Wang, Xuren Sun, Cheng Han, Zhongyan Shan, Chenyan Li, Weiping Teng
BACKGROUND: TNF-like weak inducer of apoptosis (TWEAK), its receptor fibroblast growth factor-inducible 14 (Fn14) and its scavenger receptor CD163 (sCD163) have known associations with many autoimmune diseases. However, the role of the TWEAK axis in autoimmune thyroid disease (AITD) remains unclear. Therefore, the aim of this study was to investigate the role of the TWEAK-Fn14 axis in the pathogenesis of AITD. METHODS: Serum levels of soluble TWEAK (sTWEAK) and sCD163 were measured in 38 patients with Graves' disease (GD), 40 patients with Hashimoto's thyroiditis (HT), and 40 healthy controls (HCs)...
June 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28636655/changes-in-inflammatory-biomarkers-in-hcv-infected-patients-undergoing-direct-acting-antiviral-containing-regimens-with-or-without-interferon
#2
Claudia Mascia, Serena Vita, Paola Zuccalà, Raffaella Marocco, Tiziana Tieghi, Stefano Savinelli, Raffaella Rossi, Marco Iannetta, Irene Pozzetto, Caterina Furlan, Fabio Mengoni, Claudio Maria Mastroianni, Vincenzo Vullo, Miriam Lichtner
BACKGROUND AND AIMS: Increased levels of chemokine interferon-gamma (IFN-γ)-inducible protein-10 (CXCL10), soluble CD163 (sCD163) and soluble CD14 (sCD14) have been reported in HCV infection. The aim of this study was to compare, sCD163 and sCD14 levels in HCV-infected patients undergoing direct acting antiviral (DAA)-containing regimens with or without interferon (IFN). METHODS: sCD163, sCD14 and CXCL10 were longitudinally measured by ELISA in 159 plasma samples from 25 HCV-infected patients undergoing IFN-based treatment plus telaprevir or boceprevir and 28 HCV infected subjects treated with DAA IFN-free regimens...
2017: PloS One
https://www.readbyqxmd.com/read/28618015/soluble-cd163-and-mannose-receptor-associate-with-chronic-hepatitis-b-activity-and-fibrosis-and-decline-with-treatment
#3
Tea Lund Laursen, Grace Lai-Hung Wong, Konstantin Kazankov, Thomas Sandahl, Holger Jon Møller, Stephen Hamilton-Dutoit, Jacob George, Henry Lik-Yuen Chan, Henning Grønbaek
BACKGROUND AND AIM: Liver macrophages are activated in chronic hepatitis B virus (CHB) infection and play a pivotal role in hepatic inflammation and fibrosis. However, their role during anti-viral treatment is unclear. The soluble (s) macrophage activation markers, sCD163 and mannose receptor (sMR), are released during liver damage and their serum levels reflect liver disease severity and portal hypertension. We aimed to investigate associations between sCD163 and sMR and histopathological activity and fibrosis, and changes in sCD163, sMR and hepatic CD163-expression following anti-viral treatment in CHB patients...
June 15, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28615143/monocyte-macrophage-and-t-cell-activation-markers-are-not-independently-associated-with-mi-risk-in-healthy-individuals-results-from-the-hunt-study
#4
Thor Ueland, Lars E Laugsand, Lars J Vatten, Imre Janszky, Carl Platou, Annika E Michelsen, Jan K Damås, Pål Aukrust, Bjørn O Åsvold
BACKGROUND: We hypothesized that circulating markers reflecting monocyte/macrophage and T cell activation are associated with increased risk of myocardial infarction (MI) in apparently healthy individuals. METHODS: Serum monocyte/macrophage and T cell activation markers soluble (s) CD163, sCD14, Gal3BP, sCD25 and sCD166 were analyzed by enzyme-immunoassay in a case-control study nested within the population-based HUNT2 cohort in Norway. Among 58,761 apparently healthy men and women followed a median 11...
June 11, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28578937/active-hcv-infection-is-associated-with-increased-circulating-levels-of-interferon-gamma-ifn-%C3%AE-inducible-protein-10-ip-10-soluble-cd163-and-inflammatory-monocytes-regardless-of-liver-fibrosis-and-hiv-coinfection
#5
Claudia Mascia, Miriam Lichtner, Paola Zuccalà, Serena Vita, Tiziana Tieghi, Raffaella Marocco, Stefano Savinelli, Raffaella Rossi, Marco Iannetta, Michela Campagna, Francesco Schiavone, Fabio Mengoni, Gianluca Russo, Claudio Maria Mastroianni, Vincenzo Vullo
BACKGROUND AND OBJECTIVE: Interferon-gamma (IFN-γ)-inducible protein-10 (IP-10), soluble (s) CD163 and sCD14 play an important role in the pathogenesis of HCV and HIV infection and are involved in inflammation and liver fibrosis. The aim of the present study was to evaluate at a single time point, plasma soluble biomarkers and inflammatory monocytes subsets in different groups of subjects: (i) HIV monoinfected patients on suppressive ART; (ii) HIV/HCV coinfected patients on ART, with undetectable HIV viremia (including either subjects who had active HCV replication or those who cleared HCV); (iii) HCV monoinfected individual with active viral replication...
May 31, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28569153/aberrant-monocyte-responses-predict-and-characterize-dengue-virus-infection-in-individuals-with-severe-disease
#6
Yean K Yong, Hong Y Tan, Soe Hui Jen, Esaki M Shankar, Santha K Natkunam, Jameela Sathar, Rishya Manikam, Shamala D Sekaran
BACKGROUND: Currently, several assays can diagnose acute dengue infection. However, none of these assays can predict the severity of the disease. Biomarkers that predicts the likelihood that a dengue patient will develop a severe form of the disease could permit more efficient patient triage and allows better supportive care for the individual in need, especially during dengue outbreaks. METHODS: We measured 20 plasma markers i.e. IFN-γ, IL-10, granzyme-B, CX3CL1, IP-10, RANTES, CXCL8, CXCL6, VCAM, ICAM, VEGF, HGF, sCD25, IL-18, LBP, sCD14, sCD163, MIF, MCP-1 and MIP-1β in 141 dengue patients in over 230 specimens and correlate the levels of these plasma markers with the development of dengue without warning signs (DWS-), dengue with warning signs (DWS+) and severe dengue (SD)...
May 31, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28567369/dynamic-changes-of-the-frequency-of-classic-and-inflammatory-monocytes-subsets-and-natural-killer-cells-in-chronic-hepatitis-c-patients-treated-by-direct-acting-antiviral-agents
#7
Gang Ning, Yi-Ting Li, You-Ming Chen, Ying Zhang, Ying-Fu Zeng, Chao-Shuang Lin
OBJECTIVE: Up to now, little was known about the immunological changes of chronic hepatitis C (CHC) patients treated with direct-acting antiviral agents (DAAs); we try to explore the effect of DAAs on the frequency of monocytes, NK cells, and cytokines that promote their activation. METHODS: 15 treatment-naive CHC patients and 10 healthy controls were recruited. Patients were examined before DAAs therapy (0 w) and at week 4 (4 w) and week 12 (12 w) of therapy...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28559931/soluble-plasma-proteins-st2-and-cd163-as-early-biomarkers-of-nephropathy-in-swedish-patients-with-diabetes-15-34%C3%A2-years-of-age-a-prospective-cohort-study
#8
My Samuelsson, Jonatan Dereke, Maria K Svensson, Mona Landin-Olsson, Magnus Hillman
BACKGROUND: The aim of this study was to investigate plasma levels of sST2 and sCD163 to determine whether they at an early stage could predict development of diabetic nephropathy and/or diabetic retinopathy in patients at clinical onset. METHODS: Patients diagnosed with diabetes mellitus at age 15-34 years between 1987 and 1988 (n = 220) were included. Data such as BMI, smoking, HbA1c and islet cell antibodies were collected at time of diagnosis. Within the 10 year follow-up period, 112 patients (51%) developed following diabetes related complications; retinopathy (n = 91), nephropathy (n = 12) or both (n = 9)...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28514281/acute-hyperinsulinemia-effects-on-systemic-markers-of-immune-activation-in-hiv
#9
Timothy K O'malley, Tricia H Burdo, Jake A Robinson, Kathleen V Fitch, Steven K Grinspoon, Suman Srinivasa
: The well-treated HIV population remains at risk for insulin resistance and chronic immune activation. We tested the effects of acute hyperinsulinemia on inflammation in HIV. Twenty HIV-infected and 10 non-HIV-infected individuals well-matched for BMI underwent oral glucose tolerance testing to stimulate insulin secretion and assess for changes in circulating sCD163, sCD14, and MCP-1. sCD14 decreased significantly after stimulation of hyperinsulinemia and no significant changes in sCD163 or MCP-1 were demonstrated in HIV-infected and non-HIV-infected groups...
May 16, 2017: AIDS
https://www.readbyqxmd.com/read/28462593/the-predictive-role-of-stweak-levels-in-pregnant-women-with-first-trimester-vaginal-bleeding
#10
Burcu Kasap, Ümmühani Özel Türkçü, Eren Akbaba, Behiye Sarıyıldız, Mert Küçük, Nilgün Öztürk Turhan, Gökalp Öner, Aykut Özcan
PURPOSE: To investigate the relationships of TNF-related weak inducer of apoptosis (sTWEAK), a cytokine related to the TNF superfamily, its newly described soluble receptor sCD163, and the sTWEAK/sCD163 ratio with perinatal outcomes in women with first-trimester vaginal bleeding. MATERIALS AND METHODS: Seventy (41 threatened abortion and 29 control) gestational-age-matched (6-14 weeks) pregnant women were included in the study. Antenatal complications (gestational diabetes, preeclampsia, intrauterine growth restriction, oligohydramniosis, polyhydramniosis), and perinatal outcomes (delivery mode, birth weight, delivery week) were recorded...
May 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28435287/serum-galectin-1-in-patients-with-multiple-myeloma-associations-with-survival-angiogenesis-and-biomarkers-of-macrophage-activation
#11
Morten Nørgaard Andersen, Maja Ludvigsen, Niels Abildgaard, Irma Petruskevicius, Rikke Hjortebjerg, Mette Bjerre, Bent Honoré, Holger J Møller, Niels F Andersen
Galectin-1 (Gal-1) is known to regulate cell signaling within the immune system and may be a target for new anticancer immune therapy. In patients with chronic lymphocytic leukemia (CLL) and classical Hodgkin lymphoma (cHL), high levels of Gal-1 within the tumor microenvironment were associated with worse disease state or poor outcome. Gal-1 can be secreted from cells by an unknown mechanism, and levels in blood samples were associated with high tumor burden and worse disease state in cHL and CLL patients. However, serum levels of Gal-1 have never been investigated in patients with multiple myeloma (MM)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28424360/intermittent-hypoxia-in-obstructive-sleep-apnoea-mediates-insulin-resistance-through-adipose-tissue-inflammation
#12
Aoife M Murphy, Amandine Thomas, Sophie J Crinion, Brian D Kent, Murtaza M Tambuwala, Aurelie Fabre, Jean-Louis Pepin, Helen M Roche, Claire Arnaud, Silke Ryan
Obstructive sleep apnoea (OSA) is increasingly associated with insulin resistance. The underlying pathophysiology remains unclear but intermittent hypoxia (IH)-mediated inflammation and subsequent dysfunction of the adipose tissue has been hypothesised to play a key role.We tested this hypothesis employing a comprehensive translational approach using a murine IH model of lean and diet-induced obese mice, an innovative IH system for cell cultures and a tightly controlled patient cohort.IH led to the development of insulin resistance in mice, corrected for the degree of obesity, and reduced insulin-mediated glucose uptake in 3T3-L1 adipocytes, associated with inhibition of the insulin-signalling pathway and downregulation of insulin-receptor substrate-1 mRNA...
April 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28419494/increased-levels-of-soluble-cd163-in-periodontitis-patients
#13
Laurent Detzen, Steven C Y Chen, Bin Cheng, Panos N Papapanou, Evanthia Lalla
AIM: Soluble CD163 (sCD163) has been implicated as a new biomarker in inflammatory conditions. The aim of this cross-sectional study was to assess CD163 levels systemically and locally in patients with chronic periodontitis. METHODS: sCD163 levels were measured by ELISA in serum samples from 70 periodontitis and 70 periodontally healthy subjects, and in saliva samples in a subset of the population. Two gingival biopsies were harvested per subject from 20 periodontitis patients: one from a periodontally affected site, the other from a healthy site, and the relative expression of CD163 mRNA was assessed by real-time PCR...
April 17, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28406702/an-alternatively-activated-macrophage-marker-cd163-in-severely-obese-patients-the-influence-of-very-low-calorie-diet-and-bariatric-surgery
#14
A Cinkajzlová, Z Lacinová, J Kloučková, P Kaválková, P Trachta, M Kosák, J Krátký, M Kasalický, K DoleŽalová, M Mráz, M Haluzík
CD163 is a marker of macrophages with anti-inflammatory properties and its soluble form (sCD163) is considered a prognostic predictor of several diseases including type 2 diabetes mellitus (T2DM). We explored sCD163 levels at baseline and after very low-calorie diet (VLCD) or bariatric surgery in 32 patients with obesity (20 undergoing VLCD and 12 bariatric surgery), 32 obese patients with T2DM (22 undergoing VLCD and 10 bariatric surgery), and 19 control subjects. We also assessed the changes of CD163 positive cells of monocyte-macrophage lineage in peripheral blood and subcutaneous adipose tissue (SAT) in subset of patients...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28397440/diagnostic-usefulness-of-scd163-procalcitonin-and-neopterin-for-sepsis-risk-assessment-in-critically-ill-patients
#15
Agnieszka Sapa, Alina Rak, Magdalena Wybieralska, Jakub Machoń, Anna Krzywonos-Zawadzka, Kamil Zawadzki, Marek Wełna, Mieczysław Woźniak
BACKGROUND: Sepsis is one of the most common causes of hospitalization and it is characterized by a high mortality rate in spite of the great progress in diagnosis and treatment achieved in recent years. Early diagnosis of sepsis is one of the most important elements of effective treatment. The clinical symptoms are not specific and biomarkers are considered to be useful tools in sepsis diagnostics. OBJECTIVES: The aim of our study was to evaluate the diagnostic value of sCD163 as a marker of sepsis and a comparison of it with procalcitonin and neopterin in ICU patients...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28394349/ifn-%C3%AE-3-not-ifn-%C3%AE-4-likely-mediates-ifnl3-ifnl4-haplotype-dependent-hepatic-inflammation-and-fibrosis
#16
Mohammed Eslam, Duncan McLeod, Kebitsaone Simon Kelaeng, Alessandra Mangia, Thomas Berg, Khaled Thabet, William L Irving, Gregory J Dore, David Sheridan, Henning Grønbæk, Maria Lorena Abate, Rune Hartmann, Elisabetta Bugianesi, Ulrich Spengler, Angela Rojas, David R Booth, Martin Weltman, Lindsay Mollison, Wendy Cheng, Stephen Riordan, Hema Mahajan, Janett Fischer, Jacob Nattermann, Mark W Douglas, Christopher Liddle, Elizabeth Powell, Manuel Romero-Gomez, Jacob George
Genetic variation in the IFNL3-IFNL4 (interferon-λ3-interferon-λ4) region is associated with hepatic inflammation and fibrosis. Whether IFN-λ3 or IFN-λ4 protein drives this association is not known. We demonstrate that hepatic inflammation, fibrosis stage, fibrosis progression rate, hepatic infiltration of immune cells, IFN-λ3 expression, and serum sCD163 levels (a marker of activated macrophages) are greater in individuals with the IFNL3-IFNL4 risk haplotype that does not produce IFN-λ4, but produces IFN-λ3...
May 2017: Nature Genetics
https://www.readbyqxmd.com/read/28380034/soluble-membrane-receptors-interleukin-6-procalcitonin-and-c-reactive-protein-as-prognostic-markers-in-patients-with-severe-sepsis-and-septic-shock
#17
Juan-Jesús Ríos-Toro, Mercedes Márquez-Coello, José-María García-Álvarez, Andrés Martín-Aspas, Ricardo Rivera-Fernández, Ana Sáez de Benito, José-Antonio Girón-González
BACKGROUND: The objective of this study was to explore the diagnostic and prognostic value of soluble triggering receptor expressed on myeloid cell 1 (sTREM-1), soluble cluster of differentiation 14 (sCD14), soluble cluster of differentiation 163 (sCD163), interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) serum levels for patients with severe sepsis and septic shock in an intensive care unit (ICU). METHODS: Fifty patients admitted at the ICU with the diagnosis of severe sepsis or septic shock were studied...
2017: PloS One
https://www.readbyqxmd.com/read/28355218/scd163-levels-as-a-biomarker-of-disease-severity-in-leprosy-and-visceral-leishmaniasis
#18
Ricardo Luís Louzada Silva, Marcio B Santos, Priscila L S Almeida, Thayse S Barros, Lucas Magalhães, Rodrigo A Cazzaniga, Patrícia R M Souza, Nívea F Luz, Jaqueline França-Costa, Valeria M Borges, Djalma S Lima-Junior, Michael W Lipscomb, Malcolm S Duthie, Steven G Reed, Roque Pacheco Almeida, Amélia Ribeiro Jesus
BACKGROUND: CD163, receptor for the haptoglobin-hemoglobin complex, is expressed on monocytes/macrophages and neutrophils. A soluble form of CD163 (sCD163) has been associated with the M2 macrophage phenotype, and M2 macrophages have been shown to down-modulate inflammatory responses. In particular, previous studies have shown that M2 is closely associated with the most severe clinical presentation of leprosy (i.e. lepromatous leprosy (LL)), as well as tuberculosis. We hypothesized that sCD163 correlates with severity of diseases caused by intracellular pathogens...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28350095/clinical-significance-of-scd163-and-its-possible-role-in-asthma-review
#19
Yue Zhi, Peng Gao, Xiuqin Xin, Wei Li, Lei Ji, Lin Zhang, Xueyang Zhang, Jie Zhang
Macrophages exert important functions in the balance and efficiency of immune responses, and participate in innate and adaptive immunity. The proinflammatory actions of macrophages are implicated in autoimmune diseases. Unlike classically activated M1 macrophages, the alternatively activated cluster of differentiation (CD)163+ and CD206+ M2 macrophages are involved in tissue repair and wound healing, and use oxidative metabolism to support their long‑term functions. CD163 is a member of the scavenger receptor superfamily, categorized into class B, and its soluble(s) form, sCD163, is a marker of activated M2 macrophages...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28348563/perturbations-of-monocyte-subsets-and-their-association-with-t-helper-cell-differentiation-in-acute-and-chronic-hiv-1-infected-patients
#20
Peng Chen, Bin Su, Tong Zhang, Xiaojing Zhu, Wei Xia, Yan Fu, Guoxian Zhao, Huan Xia, Lili Dai, Lijun Sun, Lifeng Liu, Hao Wu
Monocytes have been recently subdivided into three subsets: classical (CD14++CD16-), intermediate (CD14++CD16+), and non-classical (CD14+CD16++) subsets, but phenotypic and functional abnormalities of the three monocyte subsets in HIV-1 infection have not been fully characterized, especially in acute HIV-1 infection (AHI). In the study, we explored the dynamic changes of monocyte subsets and their surface markers, and the association between monocyte subsets and the IFN-γ, interleukin (IL)-4, IL-17, and TNF-α producing CD4+ T cells in acute and chronic HIV-1-infected patients...
2017: Frontiers in Immunology
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