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https://www.readbyqxmd.com/read/29341047/german-guideline-for-idiopathic-pulmonary-fibrosis-update-on-pharmacological-therapies-2017
#1
Jürgen Behr, Andreas Günther, Francesco Bonella, Klaus Geißler, Dirk Koschel, Michael Kreuter, Antje Prasse, Nicolas Schönfeld, Helmut Sitter, Joachim Müller-Quernheim, Ulrich Costabel
Idiopathic pulmonary fibrosis (IPF) is a severe and often fatal disease with a median survival of 2 - 4 years after diagnosis. Since the publication of the German IPF guideline in 2013 new treatment trials have been published, necessitating an update of the pharmacological therapy of IPF. Different from the previous guideline, the GRADE system was discarded and replaced by the Oxford evidence classification system which allows a more differentiated judgement. The following pharmacological therapies were rated not suitable for the treatment of IPF patients (recommendation A; evidence 1-b): triple therapy with prednisolone, azathioprine and acetyl-cysteine; imatinib; ambrisentan; bosentan; macitentan...
January 16, 2018: Pneumologie
https://www.readbyqxmd.com/read/29341044/antenatal-medical-therapies-to-improve-lung-development-in-congenital-diaphragmatic-hernia
#2
Aidan Kashyap, Philip DeKoninck, Kelly Crossley, Marta Thio, Graeme Polglase, Francesca Maria Russo, Jan Deprest, Stuart Hooper, Ryan Hodges
Congenital diaphragmatic hernia (CDH) is a birth defect characterized by failed closure of the diaphragm, allowing abdominal viscera to herniate into the thoracic cavity and subsequently impair pulmonary and vascular development. Despite improving standardized postnatal management, there remains a population of severe CDH for whom postnatal care falls short. In these severe cases, antenatal surgical intervention (fetoscopic endoluminal tracheal occlusion [FETO]) may improve survival; however, FETO increases the risk of preterm delivery, is not widely offered, and still fails in half of cases...
January 16, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29340522/penile-microvascular-endothelial-function-in-hypertensive-patients-effects-of-acute-type-5-phosphodiesterase-inhibition
#3
V Verri, A A Brandão, E Tibirica
The primary aim of this study was to evaluate penile endothelial microvascular function in patients with primary arterial hypertension and age-matched normotensive subjects using laser speckle contrast imaging (LSCI). Additionally, we analyzed the acute penile microvascular effects induced by oral phosphodiesterase type 5 inhibitor (sildenafil; SIL) administration. Endothelium-dependent microvascular reactivity was evaluated in the penises and forearms of hypertensive patients (aged 58.8±6.6 years, n=34) and age-matched healthy volunteers (n=33) at rest and 60 min following oral SIL (100 mg) administration...
January 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29331003/oral-sildenafil-use-in-neonates-with-persistent-pulmonary-hypertension-of-newborn
#4
Ali Shabbir Hussain, Rehan Ali, Shakeel Ahmed, Farah Naz, Anila Haroon
BACKGROUND: The prevalence of PPHN has been estimated at 1.9 per 1000 live births. After the discovery of iNO's, its efficacy and benefit in PPHN is well established. Even in the best of centers equipped with iNo and ECMO the mortality is around 20%. Also, iNO is expensive and difficult to administer and monitor which makes it difficult choice in our part of the world. Furthermore About 40% of patients do not respond or have rebound pulmonary hypertension after discontinuation. Owing to these reasons, other treatment modalities like phosphodiesterase inhibitors such as Sildenafil need to be evaluated...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29316358/continuous-intravenous-sildenafil-as-an-early-treatment-in-neonates-with-congenital-diaphragmatic-hernia
#5
Florian Kipfmueller, Lukas Schroeder, Christoph Berg, Katrin Heindel, Peter Bartmann, Andreas Mueller
BACKGROUND: Pulmonary hypertension (PH) is an important contributor of morbidity and mortality in infants with congenital diaphragmatic hernia (CDH). Treatment options are limited, but sildenafil might improve oxygenation and PH in neonates with CDH. OBJECTIVE: Aim of this study is to assess effects of intravenous sildenafil on oxygenation and PH in neonates with CDH. METHODS: A retrospective chart review was performed in all neonates with CDH born in our institution between September 2012 and December 2014...
January 5, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29310052/simultaneous-determination-of-tpn729-and-its-five-metabolites-in-human-plasma-and-urine-by-liquid-chromatography-coupled-to-tandem-mass-spectrometry
#6
Yang Liu, Shuguang Shao, Hanlin Song, Xueting Yao, Jie Liu, Hongzhong Liu, Ling Song, Ji Jiang, Dongyang Liu, Pei Hu
A specific and sensitive method was firstly developed using high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) to simultaneously quantify TPN729 and its metabolites (TPN729-D1, TPN729-D2, TPN729M15-3 and TPN729M3) in human plasma and (TPN729-D1, TPN729-D2, TPN729M15-3 and TPN729M14) in human urine. Protein precipitation and direct dilution were used to extract TPN729 and its metabolites from plasma and urine, respectively. Ionization of TPN729, TPN729-D1, TPN729-D2, TPN729M15-3, TPN729M3, TPN729M14 and sildenafil (internal standard, IS) was performed using an electrospray ionization (ESI) source in positive mode and detection was carried out with multiple reaction monitoring (MRM) mode...
December 30, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29307683/effect-of-starting-penile-rehabilitation-with-sildenafil-immediately-after-robot-assisted-laparoscopic-radical-prostatectomy-on-erectile-function-recovery-a-prospective-randomized-trial
#7
Jung Ki Jo, Seong Jin Jeong, Jong Jin Oh, Sang Wook Lee, Sangchul Lee, Sung Kyu Hong, Seok-Soo Byun, Sang Eun Lee
PURPOSE: It has not been clearly proven in real practice whether early rehabilitation with phosphodiesterase type 5 inhibitors starting immediately after radical prostatectomy improves erectile function recovery more effectively compared with delayed treatment with the same regimen. We performed a prospective randomised trial to identify this. PATIENTS AND METHODS: Patients with prostate cancer and pre-operative International Index of Erectile Function (IIEF)-5 score ≥17 were randomly assigned to regularly receive sildenafil 100mg twice a week for 3 months immediately after urethral catheter removal (early group) or only at 3 months after nerve-sparing robot-assisted laparoscopic radical prostatectomy (delayed group)...
January 4, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29301746/cyclic-gmp-elevating-agents-suppress-polyposis-in-apc-min-mice-by-targeting-the-preneoplastic-epithelium
#8
Sarah K Sharman, Bianca N Islam, Yali Hou, Nagendra Singh, Franklin G Berger, Subbaramiah Sridhar, Wonsuk Yoo, Darren D Browning
The cGMP signaling axis has been implicated in the suppression of intestinal cancers but the inhibitory mechanism and the extent to which this pathway can be targeted remains poorly understood. The present study has tested the effect of cGMP-elevating agents on tumorigenesis in the ApcMin/+ mouse model of intestinal cancer. Treatment of ApcMin/+ mice with the receptor guanylyl-cyclase C (GCC) agonist linaclotide, or the phosphodiesterase-5 (PDE5) inhibitor sildenafil, significantly reduced the number of polyps per mouse (67% and 50% respectively)...
January 4, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29295746/genuine-sildenafil-tablets-sold-in-brazil-disguised-as-mdma
#9
José Coelho Neto, Renata F P Faraco, Cíntia F Alves, Stela M M Castro, Yuri Machado
MDMA and sildenafil are two examples among many substances consumed in "raves", as well as in other types of "recreative" social events nowadays. During the first six months of 2017, five cases of supposedly MDMA tablets seized by local law enforcement forces in the state of Minas Gerais, Brazil, and brought to our forensic laboratory for examination, attracted our attention among dozens of others, as the tablets apprehended in these cases were, in fact, colorfully painted versions of genuine, pentagon-shaped, sildenafil tablets, freely available for sale in local pharmacies and drugstores...
December 20, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29289554/efficacy-and-safety-of-on-demand-use-of-2-treatments-designed-for-different-etiologies-of-female-sexual-interest-arousal-disorder-3-randomized-clinical-trials
#10
Adriaan Tuiten, Kim van Rooij, Jos Bloemers, Christoph Eisenegger, Jack van Honk, Rob Kessels, Sheryl Kingsberg, Leonard R Derogatis, Leo de Leede, Jeroen Gerritsen, Hans P F Koppeschaar, Berend Olivier, Walter Everaerd, Henderik W Frijlink, Daniël Höhle, Robert P J de Lange, Koen B E Böcker, James G Pfaus
BACKGROUND: In women, low sexual desire and/or sexual arousal can lead to sexual dissatisfaction and emotional distress, collectively defined as female sexual interest/arousal disorder (FSIAD). Few pharmaceutical treatment options are currently available. AIM: To investigate the efficacy and safety of 2 novel on-demand pharmacologic treatments that have been designed to treat 2 FSIAD subgroups (women with low sensitivity for sexual cues and women with dysfunctional over-activation of sexual inhibition) using a personalized medicine approach using an allocation formula based on genetic, hormonal, and psychological variables developed to predict drug efficacy in the subgroups...
December 27, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29283882/sildenafil-a-phosphodiesterase-5-inhibitor-offers-protection-against-carbon-tetrachloride-induced-hepatotoxicity-in-rat
#11
Olorunfemi R Molehin, Anne A Adeyanju, Stephen A Adefegha, Oluwasanmi O Aina, Blessing A Afolabi, Ayorinde O Olowoyeye, Jesutomi A Oyediran, Opeyemi R Oladiran
BACKGROUND: Elevation of phosphodiesterase-5 (PDE5) activity converts cyclic guanosine monophosphate (cGMP) to 5'-GMP, a mechanism that could be associated with drug-mediated hepatotoxicity. This study investigated whether selective inhibition of PDE5 by sildenafil could offer protection against hepatotoxicity induced by carbon tetrachloride (CCl4). METHODS: CCl4 (0.5 mL/kg) was administered intraperitoneally to induce hepatotoxicity. The control group received normal saline...
December 28, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29282893/autophagy-novel-applications-of-nonsteroidal-anti-inflammatory-drugs-for-primary-cancer
#12
REVIEW
Chen Yu, Wei-Bing Li, Jun-Bao Liu, Jian-Wei Lu, Ji-Feng Feng
In eukaryotic cells, autophagy is a process associated with programmed cell death. During this process, cytoplasmic proteins and organelles are engulfed by double-membrane autophagosomes, which then fuse with lysosomes to form autolysosomes. These autolysosomes then degrade their contents to recycle the cellular components. Autophagy has been implicated in a wide variety of physiological and pathological processes that are closely related to tumorigenesis. In recent years, an increasing number of studies have indicated that nonsteroidal anti-inflammatory drugs, such as celecoxib, meloxicam, sulindac, aspirin, sildenafil, rofecoxib, and sodium salicylate, have diverse effects in cancer that are mediated by the autophagy pathway...
December 28, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29282009/strider-sildenafil-therapy-in-dismal-prognosis-early-onset-fetal-growth-restriction-an-international-consortium-of-randomised-placebo-controlled-trials
#13
A Pels, L C Kenny, Z Alfirevic, P N Baker, Peter von Dadelszen, C Gluud, C T Kariya, B W Mol, A T Papageorghiou, A G van Wassenaer-Leemhuis, W Ganzevoort, K M Groom
BACKGROUND: Severe, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate remodelling of the maternal spiral arteries. There is currently no effective therapy available. Some evidence suggests sildenafil citrate may improve uteroplacental blood flow, fetal growth, and meaningful infant outcomes...
December 28, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29281101/sildenafil-for-improving-outcomes-in-patients-with-corrected-valvular-heart-disease-and-persistent-pulmonary-hypertension-a-multicenter-double-blind-randomized-clinical-trial
#14
Javier Bermejo, Raquel Yotti, Rocío García-Orta, Pedro L Sánchez-Fernández, Mario Castaño, Javier Segovia-Cubero, Pilar Escribano-Subías, José Alberto San Román, Xavier Borrás, Angel Alonso-Gómez, Javier Botas, María G Crespo-Leiro, Sonia Velasco, Antoni Bayés-Genís, Amador López, Roberto Muñoz-Aguilera, Eduardo de Teresa, José R González-Juanatey, Arturo Evangelista, Teresa Mombiela, Ana González-Mansilla, Jaime Elízaga, Javier Martín-Moreiras, José M González-Santos, Eduardo Moreno-Escobar, Francisco Fernández-Avilés
Aims: We aimed to determine whether treatment with sildenafil improves outcomes of patients with persistent pulmonary hypertension (PH) after correction of valvular heart disease (VHD). Methods and results: The sildenafil for improving outcomes after valvular correction (SIOVAC) study was a multricentric, randomized, parallel, and placebo-controlled trial that enrolled stable adults with mean pulmonary artery pressure ≥ 30 mmHg who had undergone a successful valve replacement or repair procedure at least 1 year before inclusion...
December 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29278046/pregnancy-affects-the-pharmacokinetics-of-sildenafil-and-its-metabolite-in-the-rabbit
#15
Francesca M Russo, Paola Mian, Elke Hj Krekels, Kristel Van Calsteren, Dick Tibboel, Jan Deprest, Karel Allegaert
There is growing interest in the use of sildenafil during pregnancy for various maternal and fetal conditions. This study aims to investigate the effect of pregnancy on the maternal pharmacokinetics (PK) of sildenafil and its main metabolite desmethylsildenafil in rabbits. Using NONMEM, population PK-modelling was performed based on plasma samples from 31 rabbits of whom 15 were pregnant and 16 were not. All received a single subcutaneous sildenafil dose of 10mg/kg. One sample was obtained per rabbit at either 30, 60, 120, 360, 720 or 1320 minutes after sildenafil administration...
December 26, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29275134/comparative-safety-of-drugs-targeting-the-nitric-oxide-pathway-in-pulmonary-hypertension-a-mixed-approach-combining-a-meta-analysis-of-clinical-trials-and-a-disproportionality-analysis-from-the-who-pharmacovigilance-database
#16
C Khouri, M Lepelley, M Roustit, F Montastruc, M Humbert, J L Cracowski
BACKGROUND: Recent guidelines recommend riociguat, a soluble guanylate cyclase (sGC) stimulator, as well as the type 5 phosphodiesterase inhibitor (PDE5i) tadalafil or sildenafil as treatments for pulmonary arterial hypertension. We compared the safety profiles of sildenafil, tadalafil and riociguat in pulmonary hypertension. METHODS: We combined two approaches: First, we performed a meta-analysis of safety data extracted from randomized controlled trials. Secondly, we conducted a disproportionality analysis of data from VigiBase, the WHO global database of individual case safety reports, to compare the safety profiles with real life data...
December 21, 2017: Chest
https://www.readbyqxmd.com/read/29245915/curcumin-interacts-with-sildenafil-to-kill-gi-tumor-cells-via-endoplasmic-reticulum-stress-and-reactive-oxygen-nitrogen-species
#17
Jane L Roberts, Andrew Poklepovic, Laurence Booth
The present studies focused on the ability of the phosphodiesterase 5 (PDE5) inhibitor sildenafil to enhance the anti-cancer properties of clinically relevant concentrations of the dietary diarylheptanoid curcumin. In gastrointestinal tumor cells, sildenafil and curcumin interacted in a greater than additive fashion to kill. Inhibition of the extrinsic apoptotic pathway suppressed killing by ∼50%, as did blockade of the intrinsic apoptotic pathway. Sildenafil and curcumin reduced mTORC1 and mTORC2 activity and increased Beclin1 levels and the numbers of autophagosomes and autolysosomes in cells in a PERK-eIF2α-dependent fashion...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29242651/perioperative-sildenafil-therapy-for-children-with-ventricular-septal-defects-and-associated-pulmonary-hypertension-undergoing-corrective-surgery-a-randomised-clinical-trial
#18
Sidharth Bhasin, Pooja Gogia, Rajeev Nair, Tapan Kumar Sahoo
Background and Aims: Sildenafil is known to reduce pulmonary artery pressure but its role in the perioperative period has not been well studied. We aimed to evaluate the efficacy of sildenafil in controlling post-operative pulmonary hypertension in children with pulmonary hypertension undergoing surgeries for correction of ventricular septal defect. Methods: The patients were divided randomly into two groups of thirty each. Group 1 (placebo) received pre-operative placebo and post-operative sildenafil (0...
October 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29241781/nifedipine-cream-versus-sildenafil-cream-for-patients-with-secondary-raynaud-phenomenon-a-randomized-double-blind-controlled-pilot-study
#19
Ximena Wortsman, Pablo Del Barrio-Díaz, Rodrigo Meza-Romero, Christine Poehls-Risco, Cristián Vera-Kellet
No abstract text is available yet for this article.
January 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29240578/case-of-bilateral-sequential-nonarteritic-ishemic-optic-neuropathy-after-rechallenge-with-sildenafil-comment
#20
Howard D Pomeranz, Joshua Kruger
No abstract text is available yet for this article.
December 12, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
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